Oral care composition to boost self-confidence

Abstract

The present invention relates to the use of an oral care composition comprising (1R,2S,5R)-N-(4-cyanomethylphenyl)-p-menthanecarboxamide to increase an individual's level and / or duration of self-confidence.

Description

Technical Field

[0002]

[0001] The present invention relates to the use of an oral care composition comprising (1R,2S,5R)-N-(4-cyanomethylphenyl)-p-menthanecarboxamide. In particular, the present invention relates to the use of an oral care composition comprising (1R,2S,5R)-N-(4-cyanomethylphenyl)-p-menthanecarboxamide for increasing an individual's confidence.

Background Art

[0002] Bad breath varies widely throughout the daily circadian rhythm and when it exceeds socially acceptable levels, it is called halitosis or oral malodour. People with good oral health seem to have a better experience in communicating with others and as a result, have high self-esteem and confidence. In the consumer market, the positioning of oral care brands with pack claims related to social confidence has mainly been linked to the product's ability to boost confidence by targeting core category benefits such as, for example, the feel of the mouth, a fresh smell and taste (for oneself and others); having a clean and healthy mouth and attractive, whiter teeth, and the pack claims are mainly an attestation of one's own certain behaviours related to social settings versus feelings. Confidence is considered to be one of the most influential motivators and regulators of behaviour in people's daily lives. Confidence is "a belief that a person can successfully perform a particular activity rather than a global trait that constitutes an optimism about overall performance".

[0003] It is known that just the thought of having a halitosis problem is sufficient to affect an individual's confidence (McKeown L. (2003) Social relations and breath odour). Studies have shown that brushing your teeth alone is sufficient to boost self-confidence (Taylor, P. et al., The Journal of Social Psychology, 2021, 182-196). However, most studies have only evaluated the immediate effect of brushing your teeth on self-confidence (i.e., immediately after brushing). Furthermore, these studies did not directly measure self-confidence, but relied only on its correlation with the desired perceptual object.

[0004] It is necessary to directly link confidence with actual consumer products. In recent years, methodologies for measuring individual confidence have been developed, such as "self-report confidence measurements," which are conducted in the form of questionnaires and ask respondents to report their level of confidence. Self-report confidence measurements capture a comprehensive self-assessment of confidence, requiring reflection on personal experiences and tendencies. Typically, items on a self-report confidence scale ask respondents to consider their confidence in a particular task or area and to select how much they agree with statements or questions about their own behavior. Therefore, such methodologies are particularly well suited to measuring individual confidence.

[0005] Coolants are mostly tasteless and odorless, yet they have nevertheless been used to create a cooling effect in consumer products such as toothpaste and mouthwash. Their use in consumer products can also affect consumers' emotional states, for example, by influencing mood and feelings, evoking positive memories and feelings of happiness. The object of the present invention is to use a coolant, particularly (1R,2S,5R)-N-(4-cyanomethylphenyl)-p-menthanecarboxamide, in an oral care composition to enhance the level of confidence and increase the lifespan of an individual's self-confidence. [Overview of the project]

[0006] In one aspect, the use of an oral care composition containing (1R,2S,5R)-N-(4-cyanomethylphenyl)-p-menthanecarboxamide to increase an individual's level of self-confidence is provided. In another aspect, the use of an oral care composition containing (1R,2S,5R)-N-(4-cyanomethylphenyl)-p-menthanecarboxamide is provided to increase the duration of an individual's self-confidence. In another aspect, the use of oral care compositions containing (1R,2S,5R)-N-(4-cyanomethylphenyl)-p-menthanecarboxamide is provided to enhance both the level and duration of an individual's self-confidence. [Brief explanation of the drawing]

[0007] [Figure 1] Figure 1 shows a comparison of breath-freshness levels measured at various time points starting 60 minutes after brushing, using flavored toothpaste alone and flavored toothpaste containing 150 ppm and 250 ppm of (1R,2S,5R)-N-(4-cyanomethylphenyl)-p-menthanecarboxamide.

[0008] [Figure 2] Figure 2 shows a comparison of confidence levels measured at various time points starting 60 minutes after brushing, using only flavored toothpaste and flavored toothpaste containing 150 ppm and 250 ppm of (1R,2S,5R)-N-(4-cyanomethylphenyl)-p-menthanecarboxamide.

[0009] definition

[0010] As used herein, "confidence" refers to a firm or strong belief in a person's ability ("ability," "the ability to do something successfully or efficiently").

[0011] The "level" of confidence relates to the strength of a person's belief in their own abilities.

[0012] The "duration" of confidence refers to the length of time a person believes they feel any measurable level of confidence.

[0013] Unless otherwise specified, all percentages and ratios are calculated in weight.

[0014] Detailed explanation

[0015] Preferred and / or optional features of the present invention are defined therefrom. Unless otherwise required by context, any aspect of the present invention may be combined with any other aspect of the present invention. Unless otherwise required by context, any preferred or optional feature of any aspect may be combined alone or in combination with any aspect of the present invention, as well as with any other preferred or optional feature.

[0016] To our surprise and unexpectedly, the applicant found that incorporating (1R,2S,5R)-N-(4-cyanomethylphenyl)-p-menthanecarboxamide into oral care compositions leads to an increase in an individual's level of confidence, duration, or both.

[0017] Therefore, it is desirable to provide an oral care composition containing (1R,2S,5R)-N-(4-cyanomethylphenyl)-p-menthanecarboxamide in order to increase an individual's level of self-confidence and to increase the duration for which an individual feels confident.

[0018] Coolant Cooling compounds, that is, chemical compounds that impart a cooling sensation to the skin or mucous membranes of the body, are well known in the art and are widely used in various products such as food ingredients, tobacco products, beverages, toothpaste, mouthwash, and toiletries.

[0019] Examples of such agents are disclosed, for example, in Leffingwell, JC, Perfumer & Flavorist, 2004, 39, 34-43 and the Research Disclosure RD 691054, which are incorporated herein by reference.

[0020] Commercially known coolants are selected from N-substituted p-menthanecarboxamides. Particularly important compounds include N-(4-cyanomethylphenyl)p-menthanecarboxamide, N-(4-sulfamoylphenyl)p-menthanecarboxamide, N-(4-cyanophenyl)p-menthanecarboxamide, N-(4-acetylphenyl)p-menthanecarboxamide, N-(4-hydroxymethylphenyl)p-menthanecarboxamide, N-(3-hydroxy-4-methoxyphenyl)p-menthanecarboxamide, or mixtures thereof. N-(4-cyanomethylphenyl)p-menthanecarboxamide is marketed by Givaudan under the trade name EverCool® 180. Other important N-substituted p-menthanecarboxanes include menthong glycerol acetal (e.g., marketed by Haarmann & Reimer as Frescolat® MGA), N-(4-cyanomethylphenyl)-p-menthanecarboxamide or N-(4-cyanomethylphenyl)-5-methyl-2-(1-methylethyl)cyclohexanecarboxamide (e.g., commercially available from Givaudan), N-(2-(pyridine-2-yl)ethyl-3-p-menthanecarboxamide (e.g., commercially available from Givaudan), and N-(4-sulfur Famoylphenyl)-p-menthanecarboxamide, N-(4-cyanophenyl)-p-menthanecarboxamide, N-(4-acetylphenyl)-ρ-menthanecarboxamide, N-(4-hydroxymethylphenyl)-p-menthanecarboxamide, N-(3-hydroxy-4-methoxyphenyl)-p-menthanecarboxamide, 2-isopropyl-N,2,3-trimethylbutyramide (e.g., known as WS-23); N-ethyl-p-menthane-3-carboxamide (e.g., known as WS-3); ethyl 3-(p-menthane-3-carboxamide) acetate (e.g., known as WS-5); menthyl lactate (e.g., marketed by Harmann & Reimer as Frescolat™ ML); menthoxypropane-1,2-diol (e.g., marketed as Coolant Agent 10 by Takasago International), p-menthane-3,8-diol (e.g., marketed as PMD38 by Takasago International), Isopulegol (e.g., marketed as "Coolact P (registered trademark)" by Takasago International), (1R,2S,5R)-2-isopropyl-5-methyl-N-(2-(pyridine-2-yl)ethyl)cyclohexane-1-carboxamide (commonly known as EVERCOOL by Givaudan) (Commercially available at 190), (1-glyceryl-p-menthane-3-carboxylate), (ethylene glycol-p-methane-3-carboxylate), ((Nt-butyl-p-menthane-3-carboxamide), (N-(4-,ethoxyphenyl)-p-menthane-3-carboxamide), 3-(1-menthoxy)), propane-1,2-diol, 3-(1-menthoxy) (2-methylpropane-1,2-diol, menthylpyrrolidone carboxylate) (e.g., commercially available as Questice®), (1R,3R,4S)-3-menthyl-3,6-dioxaheptanoate (e.g., commercially available from Firmenich), (1R,2S,5R)-3-menthyl methoxyacetate (e.g., commercially available from Firmenich), (1R,2S,5R)-3-menthyl 3,6,9-triol Xadecanoate (e.g., commercially available from Firmenich), (1R,2S,5R)-menthyl 11-hydroxy-3,6,9-trioxanedecanoate (e.g., commercially available from Firmenich), (1R,2S,5R)-3-menthyl (2-hydroxyethoxy)acetate (e.g., commercially available from Firmenich), cubebol (e.g., commercially available from Firmenich), 1-[2-hydroxyphenyl]-4-[2-nitrophenyl-]-1,2,3,This includes 6-tetrahydropyrimidine-2-one), 4-methyl-3-(1-pyrrolidinyl)-2[5H]-furanone (e.g., known as Icillin or AG-3-5), menthyl lactate, menthol glycoside-acetal, monomenthyl L-succinate, L-monomenthyl glutarate, 3-1-menthoxypropane-1,2-diol (e.g., known as Coolact 10), 2-1-menthoxyethanol (e.g., known as Coolact 5), and mixtures thereof. Additional non-menthol coolants are described in U.S. Patent No. 7,414,152, US20100086498 A1 and WO2010 / 128026 A2, and the coolants are incorporated herein by reference. Other coolants are listed in U.S. Patent Nos. 4,136,163, 4,150,052, 4,178,459, 4,190,643, 4,193,936, and 4,226,988, 4,230,688, 4,032,661, 4,153,679, and 4,296,255, 4,459,425, 5,009,893, 5,266,592, and 5,698,181. U.S. Patent Nos. 5,725,865 and 5,843,466, U.S. Patent Nos. 6,231,900, U.S. Patent Nos. 6,277,385, U.S. Patent Nos. 6,280,762 and 6,306,429 and 6,432,441, U.S. Patent Nos. 6,455,080 and 6,627,233 and 7,078,066, U.S. Patent Nos. 6,783,783, U.S. Patent Nos. 6,884,906, U.S. Patent Nos. 7,030,273, and U.S. Patent Nos. 7,090,Disclosed in No. 832; US2004 / 0175489, US2004 / 0191402, US2005 / 0019445, US2005 / 0222256 and US2005 / 0265930, US2006 / 0159819, US2006 / 0249167, EP1689256 A1; and WO 2005 / 082154 A1, WO 2005 / 099473 A1, WO 2006 / 058600 A1, WO 2006 / 092076 A2, and WO 2006 / 125334 A1, all of which are incorporated herein by reference.

[0021] In particular, (1R,2S,5R)-N-(4-cyanomethylphenyl)-p-menthanecarboxamide (also known as EC 180) is disclosed in WO2005 / 049553 as exhibiting a strong and long-lasting cooling effect, especially when used in oral care compositions such as mouthwash or toothpaste. (1R,2S,5R)-N-(4-cyanomethylphenyl)-p-menthanecarboxamide provides a long-lasting feeling of freshness in the mouth, but it itself has no aroma (flavor) and therefore does not contribute to a pleasant-smelling breath. Surprisingly, despite its lack of aroma, (1R,2S,5R)-N-(4-cyanomethylphenyl)-p-menthanecarboxamide has now been found to boost confidence.

[0022] Having fresh-smelling breath often contributes significantly to an individual's confidence in social interactions and situations. While (1R,2S,5R)-N-(4-cyanomethylphenyl)-p-menthanecarboxamide does not contribute to confidence-related benefits such as a clean, healthy mouth and pleasant-smelling breath, it was found that (1R,2S,5R)-N-(4-cyanomethylphenyl)-p-menthanecarboxamide enhances confidence compared to the flavor alone, and this enhanced confidence lasts for an extended period.

[0023] The present invention shows that the adoption of (1R,2S,5R)-N-(4-cyanomethylphenyl)-p-menthane carboxamide in an oral care composition leads to an increase in consumer confidence in addition to the known cooling effect. The increased effect is related to both the magnitude and duration of the effect.

[0024] Flavor component Flavor components are incorporated into oral care compositions such as toothpaste, mouthwash, chewing gum, among others, to impart to the consumer a signal that the product may deliver freshness and cleanliness upon use. When the product has a fresh taste and smell, these are key indicators to the consumer that the teeth, mouth, and breath are cleaned upon use.

[0025] Examples of flavor components include natural flavors, artificial flavors, spices, seasonings, etc. Exemplary flavor components include synthetic flavor oils and flavor aromatics and / or oils, oleoresins, essences, and distillates, and combinations containing at least one of the foregoing.

[0026] Flavor oils include artificial, natural, and synthetic fruit flavors such as spearmint oil, cinnamon oil, wintergreen oil (methyl salicylate), peppermint oil, Japanese mint oil, clove oil, bay oil, anise oil, eucalyptus oil, thyme oil, sassafras oil, nutmeg oil, allspice, sage oil, mace, bitter almond oil, cassia oil, vanilla, and citrus oils such as lemon, orange, lime, grapefruit, yuzu, sudachi, fruit essences such as apple, pear, peach, grape, raspberry, blackberry, gooseberry, blueberry, strawberry, plum, prune, raisin, cola, guarana, neroli, pineapple, apricot, banana, melon, apricot, cherry, tropical fruit, mango, mangosteen, pomegranate, papaya.

[0027] Additional example flavors imparted by the flavor composition include: milk flavor, butter flavor, cheese flavor, cream flavor, yogurt flavor; vanilla flavor; tea or coffee flavors such as green tea flavor, oolong tea flavor, tea flavor, cocoa flavor, chocolate flavor, and coffee flavor; mint flavors such as peppermint flavor, spearmint flavor, and Japanese mint flavor; agi flavor, ajwain flavor, anise flavor, angelica flavor, fennel flavor, allspice flavor, cinnamon flavor, chamomile flavor, mustard flavor, cardamom flavor, caraway flavor, cumin flavor, clove flavor, pepper flavor, coriander flavor, sassafras flavor, savory flavor, xylifructus flavor, perilla flavor, and juniper berry flavor. Spicy flavors such as spice, ginger, star anise, horseradish, thyme, tarragon, dill, chili pepper, nutmeg, basil, marjoram, rosemary, bay leaf, and wasabi (Japanese horseradish); nutty flavors such as almond, hazelnut, macadamia nut, peanut, pecan, pistachio, and walnut; alcoholic flavors such as wine, whiskey, brandy, rum, gin, and liqueur; floral flavors; and vegetable flavors such as onion, garlic, cabbage, carrot, celery, mushroom, and tomato.

[0028] In general, any flavor or food additive (including food colorings) as described in Leatherhead Food International Ltd.'s “Essential guide to food additives,” Third edition, 2008, pages 101-321 (ISBN: 978-1-905224-50-0) may be used. That publication is incorporated herein by reference.

[0029] Many flavor types are known and potentially used in the oral care field, but flavor compositions containing mint oils, such as peppermint and spearmint oils, are particularly popular in oral care formulations. Mint oil is typically used to create a refreshing sensation because it naturally contains menthol, which has physiological cooling properties. Regardless of the flavor type, the inclusion of additional menthol often enhances this refreshing impression.

[0030] A typical peppermint flavor may contain anethole (up to 20%, e.g., 5-15%), menthol (up to 70%, e.g., 20-50%), Mentha arvensis (up to 70%, e.g., 10-30%), Mentha piperita (up to 50%, e.g., 10-30%), Mentha spicata and / or L-carvone (up to 20%, e.g., 5-15%), and other flavor or fragrance components.

[0031] A typical spearmint flavor may include anethole (up to 20%, e.g., 5-15%), menthol (up to 50%, e.g., 15-30%), Mentha spicata and / or L-carvone (up to 50%, e.g., 20-40%), Mentha arvensis and / or Mentha piperita (up to 50%, e.g., 10-30%), and other flavor or fragrance components.

[0032] In one aspect, the flavor components are present in a range of about 0.02% to about 10% by weight, preferably in a range of about 0.2% to about 5.0% by weight, and more preferably in a range of about 0.3% to about 3.0% by weight.

[0033] While flavor is particularly important in providing a pleasant-smelling breath, WO2004 / 073669A1 indicates that because the oral retention time of flavors is relatively short, often less than 10 minutes, confidence in the correlation between the freshness of breath provided solely by flavored toothpaste diminishes rapidly after use.

[0034] This was confirmed by monitoring both the level of breath freshness and the level of confidence reported by many participants in this study, as shown by the dashed lines in Figures 1 and 2, demonstrating that the level of confidence slightly increased 10 minutes after brushing, despite a decline in the level of breath freshness. Subsequently, both the level of breath freshness and the level of confidence significantly decreased over 60 minutes.

[0035] Therefore, this invention demonstrates that brushing teeth with flavored toothpaste alone was only sufficient to maintain a certain level of confidence for a short period, such as about 10 minutes. However, the level of confidence then began to decline, and the value dropped significantly after about 60 minutes (Figure 1).

[0036] In contrast, the presence of (1R,2S,5R)-N-(4-cyanomethylphenyl)-p-menthane in flavored toothpaste used for brushing significantly increased confidence levels 10 minutes after brushing, despite providing the same level of breath freshness over the same period (solid and dotted lines in Figures 1 and 2). Confidence levels remained elevated for up to approximately 30 minutes after brushing, and the effect was still observed 60 minutes after brushing, even though breath freshness levels steadily decreased over the same period.

[0037] In one embodiment, (1R,2S,5R)-N-(4-cyanomethylphenyl)-p-menthanecarboxamide is used at levels of 2 to 800 ppm, optionally 20 to 500 ppm, particularly 50 to 400 ppm, more specifically 100 to 300 ppm, and even more specifically 150 to 250 ppm, based on the weight of the oral care composition.

[0038] Oral care composition Oral care compositions, such as toothpaste or mouthwash, may be formulated in conventional ways well known to those skilled in the art. In one embodiment, the oral care composition contains (1R,2S,5R)-N-(4-cyanomethylphenyl)-p-menthanecarboxamide in addition to a flavor component.

[0039] In one embodiment, the oral care composition further comprises at least one orally acceptable carrier. The orally acceptable carrier may include one or more solid or liquid excipients or diluents that are publicly suitable for topical oral administration. "Compatibility" means, when used herein, that the components of the composition can be mixed in such a way that substantially reduces their stability and / or efficacy without interaction. Carriers may include common and conventional components of toothpastes, non-abrasive gels, subgingival gels, mouthwashes or rinses, mouth sprays, chewing gums, lozenges, and breath mints. The choice of carrier used is essentially determined by the method of introducing the composition into the oral cavity. Carrier materials such as toothpastes, toothpaste gels, etc., include abrasives, foaming agents, binders, humectants, flavoring agents, sweeteners, etc., as disclosed, for example, in U.S. Patent No. 3,988,433. Carrier materials for biphasic toothpaste formulations are disclosed in U.S. Patent Nos. 5,213,790; 5,145,666 and 5,281,410 and U.S. Patents 4,849,213 and 4,528,180. Carrier materials for mouthwash, rinse, and mouth spray typically include water, flavorings, and sweeteners, as disclosed in U.S. Patent No. 3,988,433, etc. Lozenge carrier materials typically include a candy base; chewing gum carrier materials include a gum base, flavorings, and sweeteners, as disclosed, for example, in U.S. Patent No. 4,083,955. Sachet carrier materials typically include a sachet bag, flavorings, and sweeteners. For subgingival gels used to deliver active substances into or around periodontal pockets, “subgingival gel carriers” are selected, as disclosed, for example, in U.S. Patents 5,198,220 and 5,242,910. Suitable carriers for the preparation of the compositions of this disclosure are well known in the art. Their selection will depend on secondary considerations such as taste, cost, and storability. More preferred types of orally acceptable carrier materials or excipients are listed in WO2010 / 059289, particularly on pages 17-31, which is incorporated as reference material.

[0040] In one embodiment, the oral care composition is toothpaste.

[0041] In one aspect, confidence is confidence in a person's oral hygiene.

[0042] The present invention can be further illustrated by the following non-limiting examples.

[0043] Measurement method We used a nine-item subscale of the modified Competitive State Anxiety Questionnaire (CSAI-2) to measure individuals' perceptions and feelings about their self-confidence based on their perceived oral health (e.g., breath). The Competitive State Anxiety Questionnaire (CSAI) was originally designed by Martens et al. to test anxiety in competitive performance (Martens, RB et al, (1990), Development and validation of the competitive state anxiety inventory-2. Competitive anxiety in sport, Human Kinetics, Chapaign, 117-190). Later, a third subscale labeled "confidence," characterized by positive expectations of success, was added (CSAI-2) (Cerin, E., J. Appl. Sport psychology, 2003, 15, 223-238). CSAI-2 has become a go-to tool for measuring anxiety before intense performances (such as sports or musicals). A reduced version of the questionnaire, employing only one subscale, was validated by Arruza Gabilondo et al. (Arruza Gabilondo, JA et al, Revista Internacional de Medicina y Ciencias de la Actividad Fisica y del Deporte, 2012, 47, 539-556). Recent oral care research (Dumitrescu, AL et al, Int. J. Dent. Hygiene, 2012, 22-29) has tested confidence using a nine-item confidence subscale from the Competitive State Anxiety Questionnaire-2 (CSAI-2).

[0044] The nine items on the confidence scale consisted of five items describing positive expectations ("I feel confident," "I am confident I can handle challenges," "I am confident I will perform well," "I am confident I can achieve my goals because I have a mental image of myself achieving them," and "I am confident I can overcome pressure") and four items describing generalized feelings of calmness ("I am calm," "I feel comfortable," "I feel at ease," and "I am mentally relaxed"). All items were rated on a four-point scale, fixed between 1 ("not at all") and 4 ("very much so").

[0045] participants This home use study was conducted in the UK in July / August 2022. Twenty-six participants underwent pre-screening to ensure they did not have underlying dental problems.

[0046] Study design and procedure A repeated measures design was used, with randomized repeated trials conducted for each product. The three toothpastes were prepared as follows: - Comparison: Peppermint flavor -EC180-150ppm: Peppermint flavor + 150ppm EC180 (concentration in toothpaste) -EC180-250ppm: Peppermint flavor + 250ppm EC180 (concentration in toothpaste)

[0047] Table 1 shows the basic ingredients of toothpaste. [Table 1]

[0048] Flavor compositions including (1R,2S,5R)-N-(4-cyanomethylphenyl)-p-menthanecarboxamide (EC180) are shown in Table 2. [Table 2]

[0049] Participants were given duplicate tubes of each toothpaste (a total of 6 tubes). Each product was assigned a different code, and white tubes were presented to avoid color being a confounding factor.

[0050] Participants underwent testing at home each morning during their usual teeth cleaning time (between 7:00 am and 10:00 am), and were asked to refrain from using any other oral practices besides brushing with the test product. Testing was conducted with one product per day, with a one-day interval before testing the next product. They were sent questionnaires via online links to complete before and after their teeth cleaning. Their responses before teeth cleaning were recorded as their baseline score.

[0051] Data from this study were collected through an online questionnaire set up via SurveyMonkey Audience. The questionnaire regarding breath freshness and confidence was designed for participants to complete at five time points: (i) baseline before brushing, (ii) 0 minutes immediately after brushing, (iii) 30 minutes after brushing, and (iv) 60 minutes after brushing. A total of 47 datasets per product were entered for analysis, and five incomplete datasets were removed.

[0052] measurement Breath freshness assessment The freshness of exhaled breath was self-assessed using a set of three questions: (i) overall cleanliness of the mouth, (ii) natural freshness in the oral cavity, and (iii) feeling of coolness in the oral cavity. To obtain self-assessed measurements of exhaled breath, participants were asked to refrain from eating, drinking, and practicing oral hygiene for at least one hour before brushing their teeth and throughout the entire assessment period after brushing. Exhaled breath assessments recorded before brushing were classified as baseline measurements.

[0053] confidence Confidence was measured using a nine-item subscale of the Modified Competitive State Inventory-2 (CSAI-2). The questionnaire uses a four-point scale as follows: 1 - Not at all, 2 - To some extent, 3 - Moderately, 4 - Very much so.

[0054] Example 1: Assessment of baseline breath freshness and confidence score The baseline mean and standard deviation (SD) before brushing were calculated across products and are shown in Tables 3 and 4 below. Two-way ANOVA revealed a p-value greater than 0.05, indicating no significant differences between products in breath assessment and pre-brushing confidence. This suggests that participants' pre-brushing breath freshness and confidence were estimated to be nearly the same across test days prior to product use. [Table 3] [Table 4]

[0055] Table 5 shows baseline summary statistics (before brushing) for participants' confidence and breath freshness. There were no significant differences in baseline measurements between products in either questionnaire. [Table 5]

[0056] Example 2: Delta breath freshness assessment and confidence score To evaluate the effect of changes from baseline (before brushing) to various time points after brushing, the mean difference between the baseline mean score and the mean score at each time point was calculated to obtain a delta value.

[0057] Delta Breath Freshness Assessment Figure 1 shows the changes over time in EC 180-150 ppm, EC 180-250 ppm, and the average delta value of breath freshness for the control group. A two-way ANOVA (Table 6) revealed a statistically significant difference in the mean breath freshness score between toothpaste product (F(2,552)=10.298, p=0.000) and time (F(3,552)=33.322, p=0.000).

[0058] In a post-hoc analysis using Tukey's HSD, a test for multiple comparisons, the mean values ​​of toothpaste products were found to be significantly different from the control product at both levels of EC180 at all time points after brushing. There were no significant differences between the levels of EC180.

[0059] Tukey's Honest Significant Difference (HSD) test is a post-hoc analysis commonly used to assess significant differences between pairs of group means.

[0060] [Table 6]

[0061] Delta Confidence Assessment Delta values ​​were calculated as the change from baseline. Figure 2 shows the change in confidence mean delta values ​​for EC180-150ppm, EC180-250ppm, and control.

[0062] A two-way ANOVA (Table 7) revealed a statistically significant difference in mean confidence scores between toothpaste product (F(2,552)=37.465, p=0.000) and time (F(3,552)=4.120, p=0.007). In a post-hoc analysis using Tukey's HSD, a multiple comparison test, the mean levels of toothpaste products were statistically significant between the control product and the EC180 level of 250 ppm at 30 minutes (p=0.071, 90%CI=[-0.576,-0.020]) and 60 minutes (p=0.009, 90%CI=[-0.642,-0.119]). There was no statistically significant difference between the toothpaste products at 0 and 10 minutes.

[0063] [Table 7]

[0064] Therefore, it is clear that while the freshness of breath begins to decrease significantly 10 minutes after brushing with toothpaste containing EC180 (reaching approximately 60% of the initial level 60 minutes after brushing), the person's confidence remains at a considerable level (over 80%) even 60 minutes after brushing, compared to the level achieved immediately after brushing with toothpaste containing EC180.

[0065] Furthermore, when toothpaste containing EC180 was used, the freshness of breath increased only minimally up to 10 minutes after brushing compared to immediately after brushing (0 minutes), while a significant increase in confidence level was observed 10 minutes after brushing compared to immediately after brushing (0 minutes).

Claims

1. Use of an oral care composition containing (1R,2S,5R)-N-(4-cyanomethylphenyl)-p-menthanecarboxamide to increase an individual's level of self-confidence.

2. Use of an oral care composition containing (1R,2S,5R)-N-(4-cyanomethylphenyl)-p-menthanecarboxamide to increase the duration of an individual's self-confidence.

3. Use of an oral care composition containing (1R,2S,5R)-N-(4-cyanomethylphenyl)-p-menthanecarboxamide to enhance an individual's level and duration of confidence.

4. The use according to any one of claims 1 to 3, wherein the individual's confidence is their confidence in their oral hygiene.

5. The use according to any one of claims 1 to 4, wherein the oral care composition further comprises at least one flavor component.

6. At least one flavor ingredient is artificial, natural, or synthetic fruit flavors such as spearmint oil, cinnamon oil, wintergreen oil, peppermint oil, Japanese mint oil, clove oil, bay oil, anise oil, eucalyptus oil, thyme oil, cedar leaf oil, nutmeg oil, allspice, sage oil, mace, bitter almond oil, cassia oil, vanilla, and citrus oils such as lemon, orange, lime, grapefruit, yuzu, sudachi, apple, pear, peach. The use according to any one of claims 1 to 5, selected from the group consisting of fruit essences such as grape, raspberry, blackberry, currant, blueberry, strawberry, cherry, plum, prune, raisin, cola, guarana, neroli, pineapple, apricot, banana, melon, tropical fruit, mango, mangosteen, pomegranate, papaya, and mixtures thereof, wherein optionally at least one flavor component is peppermint oil, spearmint oil, or a combination thereof.

7. The use according to any one of claims 1 to 6, wherein (1R,2S,5R)-N-(4-cyanomethylphenyl)-p-menthanecarboxamide is used at a level of 2 to 800 ppm, optionally 20 to 500 ppm, particularly 50 to 400 ppm, more specifically 100 to 300 ppm, and even more specifically 150 to 250 ppm, based on the weight of the oral care composition.

8. The use according to any one of claims 1 to 7, wherein the oral care composition is toothpaste or mouthwash, and optionally the oral care composition is toothpaste.

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