Valve block for solution management system for bioprocesses

Abstract

This disclosure relates to a valve block 100 for controlling the flow of fluid in and / or out of a solution management system 200 for a bioprocess, wherein the valve block 100 is a single unit and comprises at least one inlet port 10, at least one outlet port 20, and four or more valve sections 30 fluid-connected to at least one inlet port 10 and at least one outlet port 20, each valve section 30 being configured to receive a valve element 32 for controlling the fluid passing through the valve block 100, wherein at least two valve sections 30 are fluid-connected to each other by an integrally formed first channel 40, the first channel changing direction two or more times.

Description

Technical Field

[0001] The present disclosure relates to a valve block for controlling the flow of fluids flowing into and / or out of a solution management system for a bioprocess, and a solution management system for a bioprocess comprising such a valve block. More specifically, the present disclosure relates to a valve block as defined in the introductory part of the independent claims, and a solution management system for a bioprocess comprising such a valve block.

Background Art

[0002] Valve blocks are used in various applications and are typically manufactured from solid blocks. A valve block comprises one or more inlet ports, outlet ports, and valves connected by drilled channels inside the valve block. The channels are linear, but a 90-degree change in direction can be obtained by drilling two channels perpendicular to each other so as to intersect. Commonly known valve blocks are often combined or stacked together to achieve a desired flow path by the connected channels. However, combining valve blocks requires a sealing mechanism between the valve blocks to prevent leakage.

[0003] In a solution management system for a bioprocess, valve blocks are used at the inlet of the solution and / or at the outlet of the solution. Such a system may comprise a plurality of inlets and outlets for different solutions or fluids, and multiple valve blocks are often combined. As mentioned above, a sealing mechanism is required to combine valve blocks. Sealing generally results in small gaps and, in the worst case, acts as a dirt trap, leading to cross-contamination. This is a problem with known valve blocks.

Summary of the Invention

Problems to be Solved by the Invention

[0004] The object of the present invention is to provide a valve block for a solution management system for bioprocesses that solves or mitigates at least some of the problems associated with conventional valve blocks used for managing solutions and buffers in the pharmaceutical and biotechnology industries. [Means for solving the problem]

[0005] According to a first aspect of the present disclosure, a valve block is provided for controlling the flow of fluid into and / or out of a solution management system for a bioprocess in a sterilization / sterile environment, the valve block being a single unit comprising at least one inlet port, at least one outlet port, and four or more valve sections fluid-connected to at least one inlet port and at least one outlet port, each valve section configured to receive a valve element for controlling fluid through the valve block, the valve block comprising at least two valve sections fluid-connected by a first channel integrally formed, the first channel changing direction two or more times.

[0006] In a single-unit valve block (monoblock) having four or more valve sections, as disclosed herein, a first integrally formed channel whose direction can be changed two or more times allows for the transport of fluid within the single valve block in a more flexible and complex manner. For example, the first channel allows bypassing valve sections, channels, inlet ports, or outlet ports in the same plane within the valve block. In this way, valve sections, inlet ports, and outlet ports in a valve block that are not adjacent to each other can be fluidly connected in a space-efficient manner. Therefore, instead of increasing the thickness of the valve block to bypass components in different planes, the first channel allows the valve block disclosed herein to be more compact and use less material, thereby reducing weight. This is advantageous from a sustainability standpoint and facilitates the installation and maintenance of the valve block in a solution management system. The integrally formed first channel also enhances the ability to provide customized flow paths within the valve block, thereby reducing the need to combine multiple valve blocks. In this way, sealing and potential cross-contamination between different valve blocks can be avoided.

[0007] The valve section within the valve block may be directly or indirectly connected to at least one inlet port and at least one outlet port. Thus, the valve section may be directly connected to the inlet port and / or outlet port, or it may be connected to the inlet port and / or outlet port via another valve section.

[0008] The first channel may have a substantially constant cross-sectional area. Therefore, the cross-sectional area of ​​the first channel may remain essentially the same along its extension, even when the direction is changed. In this way, a reduction in constraints on the flow within the first channel and a reduction in back pressure can be achieved.

[0009] In one example, at least two fluid-connected valve sections are positioned diagonally within a valve block. Fluid-connecting two diagonally positioned valve sections can be difficult in conventional valve blocks because it requires several intersecting linear perforated channels. By having a first integrally formed channel that changes direction at least twice, the diagonally positioned valve sections can be fluid-connected in a space-efficient manner.

[0010] Four or more valve units can all be fluidically connected to one another. The valve units can be fluidly connected via a centrally located channel to at least one inlet port and / or at least one outlet port. Alternatively, four or more valve units can be fluidly connected to one another by different channels that sequentially connect them.

[0011] Valve blocks can be manufactured by additive manufacturing. Alternatively, valve blocks can be manufactured by molding or casting. By using additive manufacturing, molding, or casting, valve blocks can be configured with the desired flow paths in a space-efficient manner. This allows valve blocks to be more compact and require less material. Additive manufacturing or 3D printing can be performed with polypropylene (PP), polyetherketone (PEEK), stainless steel, or other materials compatible with typical bioprocess process fluids and cleaning agents. Since valve blocks can be 3D printed or molded from different plastic materials, CO2 emissions in the production of such valve blocks are reduced compared to valve blocks containing metal. Furthermore, since valve blocks can be printed or molded from plastic, the weight of the valve block is reduced. Also, by allowing for more freedom in channel formation, channels can be routed to have at least one inlet port and / or at least one outlet port located lower than the valve section. This can improve the drainage of the valve block.

[0012] Such 3D printed parts may also be printed and / or surface treated to enable optimized cleaning or minimized biological contaminant adhesion (e.g., by surface heat treatment - see International Publication 2023 / 156477, International Application PCT / EP24 / 050808, SE2350629-8, and / or International Publication 2024 / 061643, which are fully incorporated herein by reference).

[0013] In one example, the first channel is separated by channel walls having a thickness between 1.6 and 5 millimeters. The thickness of the channel walls of the first channel may vary along the extension of the first channel. It should be understood that the first channel and any other channels in a valve block disclosed herein may be referred to as conduits, pipes, or passages. All channels within a valve block may be separated by channel walls having a thickness between 1.6 and 5 millimeters. The first channel separated by channel walls having a thickness between 1.6 and 5 millimeters is a valve block that differs from conventional solutions where the channel is a perforated hole in a solid block. Instead of removing material from a solid block (perforating), the valve block can be constructed to be hollow to some extent by forming walls of a certain thickness. In this way, less material is used and the weight of the valve block is reduced.

[0014] The channel wall separating the first channel may be continuous along the longitudinal extension of the first channel. Having a first channel with a continuous wall without joints or seals allows for better flow within the valve block and reduces the risk of leakage and contamination. Furthermore, the continuous wall may improve fluid flow within the channel.

[0015] In one example, the valve block further comprises a second channel, and the first and second channels extend in different planes within the valve block and pass through each other without intersecting. At least two changes in the direction of the first channel allow for a more space-efficient routing of the channel within the valve block. The second channel may be configured similarly to the first channel and therefore may change direction two or more times. Alternatively, the second channel may be configured differently from the first channel. The valve block may comprise multiple channels, which may or may not be similar to the first channel. Some channels may be linear, others may change direction only once, and others may change direction three or more times.

[0016] The first channel may comprise at least two curved sections that change the direction of the first channel at least twice. The curved sections may be configured such that the first channel is essentially U-shaped or S-shaped. Each curved section may be configured to provide essentially a 90-degree change of direction. In some examples, the curved sections are configured to provide a change of direction between 45 and 135 degrees. The curved sections may be configured to provide a change of direction in the x, y, or z direction.

[0017] The first channel may comprise at least two curved sections that change the direction of the first channel at least twice, wherein at least one of the curved sections is configured such that its radius of curvature changes along at least a portion of the length of the curved section. The radius of curvature of at least one curved section may change while maintaining a constant cross-sectional area of ​​the first channel. In this way, sharp bends and corners can be avoided and a continuous flow of fluid within the channel can be achieved. In another example, at least one curved section of the first channel has an internal cross-sectional shape that changes along at least a portion of the length of the curved section. Thus, the first channel may have a cross-sectional shape that changes along at least a portion of the length of the first channel.

[0018] By having a radius of curvature and / or cross-sectional shape that varies along at least a portion of the length of the curved section, problems related to hold-up volume in the channel can be reduced, steady-state flow can be reached more quickly, back pressure can be lower, and the risk of stagnation zones in the channel can be reduced. Also, compared to conventional valve blocks with perforated right-angle bends, lower pressure drops before and after the curved section can be achieved, resulting in smoother flow. The pressure drop before and after a substantially 90° curved section with a radius of curvature and / or cross-sectional shape that varies along at least a portion of the length of the curved section can reduce the flow rate of the solution through the channel by at least 2000-2400 l / h compared to a corresponding substantially 90° curved section with a constant inner cross-sectional shape and / or radius of curvature.

[0019] The inner diameter of the first channel may be between 2 and 21 millimeters. The diameter is preferably greater than 6 millimeters. In some examples, the inner diameter of the first channel is one of 3, 6, 10, 14, and 20.4 millimeters.

[0020] In addition to reducing back pressure, the lower hold-up volume within the valve block also results in a reduction in bioburden (e.g., trapped biological contaminants) within it. The improved, substantially smoother fluid flow (e.g., over the operating range of increased pressure) can also be designed into solution management systems, etc., that incorporate such valve blocks (e.g., located between one or more inlet tubes / channels and one or more solution outlet tubes / channels), which may further include multiple components that are themselves fluidly connected by bends / tubes / channels / pipes.

[0021] In an example of the present disclosure, each valve portion comprises a recess having a sealing surface configured to receive and contact a valve element in the form of a membrane or diaphragm. Thus, a valve portion within a valve block may form part of a diaphragm valve. The valve portion of the valve block may further comprise two or more ports connected to a channel within the valve block, and a seat between the ports. The valve is closed when the membrane or diaphragm is pressed against the seat. The movement of the membrane or diaphragm for opening and closing the valve may be controlled by an actuator. The actuator may be mechanical, pneumatic, hydraulic, or electric. Alternatively, the actuator may be manually driven.

[0022] According to an example of this disclosure, a valve block has six sides and further comprises at least one integrally formed hose connector portion projecting from the valve block in relation to at least one inlet port or at least one outlet port, wherein the at least one hose connector portion extends longitudinally at an angle to the side of the valve block on which the hose connector portion is located, and the angle is in the range of 30 to 85 degrees. Thus, the hose connector portion is inclined or sloped with respect to the side of the valve block on which the hose connector portion is located. The hose connector portion is configured to connect to a hose, which in turn connects to a fluid source for supplying fluid to a system or a fluid receiver for receiving fluid from a system. The hose connector portion is an integral part of the valve block. The hose connector portion is coaxially located with respect to at least one inlet port or at least one outlet port. Conventional valve blocks typically have hose connectors that extend perpendicularly to the vertically positioned sides of the valve block, or to which hose connectors are connected. This can cause problems in which the hose twists and obstructs the flow. The force exerted on the hose connector by the weight of the hose can also damage the hose connector. The angled hose connector reduces the load on the hose connector and the risk of the hose twisting. The hose connector according to this disclosure also allows for a more space-efficient placement because the connected hose extends closer to the valve block. This also reduces the risk of an operator stepping on the hose, thereby applying an external load to the hose connector and ultimately damaging it. Further details regarding the hose connector are described below in relation to a second aspect of this disclosure.

[0023] According to a first aspect of this disclosure, a solution management system for a bioprocess is also provided. The system comprises a valve block as disclosed above. It should be understood that all the effects and advantages of the valve block according to the first aspect are also applicable to the solution management system of the first aspect.

[0024] In one example, the system further comprises an actuator package having at least one actuator and a valve element connected to at least one actuator. In another example, the system further comprises an actuator package having at least four actuators and a valve element connected to each actuator, the valve block being connected to the actuator package such that the valve element is aligned and sealed between the valve block and the actuators to the valve portion of the valve block. As discussed above, the valve element may be a membrane or diaphragm and is positioned between the individual actuator and the valve block. The actuator is configured to move the central portion of the individual valve element toward or away from the valve portion of the valve block in order to close or open the valve. Each valve may be closed by pressing the central portion of the valve element against the valve portion of the valve block, causing it to contact the seat of the valve portion. In this way, the fluid is unable to pass between the two ports of the valve portion. Each valve may be opened by releasing the pressure / force on the valve element so that the valve element does not contact the seat of the valve portion in the valve block. The system may be configured so that all valves are closed by default. It should be understood that the system may comprise multiple valve blocks and corresponding actuator packages.

[0025] An actuator package may further comprise at least one actuator clamp for holding at least one actuator, and the actuator package is mounted to the system by at least one actuator clamp being connected to the support structure of the system. An actuator claim may be configured to clamp at least two actuators together, thereby mounting at least two actuators to the system by at least one actuator clamp being connected to the support structure of the system. The system typically comprises a support structure such as a frame, beam, or column for various components to be connected. The actuator clamp facilitates handling several actuators simultaneously and thus allows several actuators to be mounted to the system in a simple manner. The support structure may include at least one recess, slot, or opening configured to receive a corresponding projection on the actuator clamp, thereby connecting the actuator package into the system. In one example, the support structure comprises an upper column and a lower column, and the actuator clamp is positioned between these columns and engages with both columns. The actuator clamp, and therefore the actuator package, may be connected to the support structure to allow lateral movement of the actuator package. This increases the tolerance, thus facilitating the mounting of the actuator package and the connection of the valve block.

[0026] The valve block can be attached to the actuator by fasteners, which are appropriately bolts or screws. When assembling the system, the actuators of each actuator package are first clamped together by at least one actuator clamp. The actuator package is then mounted by connecting the actuator clamp to the support structure of the system. Subsequently, the valve block is aligned with the actuator package and connected to the actuator by fasteners. The valve block is positioned so that at least one side faces outward away from the system and is therefore easily accessible from outside the system. This method of connecting various components and mounting them to the system also improves and simplifies handling during maintenance compared to conventional solutions. In solution management systems for bioprocesses, valve elements are typically replaced once a year or may need to be replaced due to excessive wear. In the system disclosed herein, the valve elements are accessed by removing the entire valve block from the corresponding actuator (by loosening the screws). Since the actuator package is connected to the support structure via the actuator clamp, the valve block can be removed without affecting the stability of the actuator package. Molded or printed valve blocks are also relatively lightweight, which allows them to be easily removed from the system. In conventional systems, the valve elements are accessed by removing the actuator. This is more cumbersome, as the actuator is usually located inside the valve block and is therefore not as easily accessible. Furthermore, actuators can be very heavy, which can complicate maintenance. As mentioned above, the valve can be closed by default. This means that, by default, the valve elements are pressed against the seat of the valve section by the actuator.In such a case, in order to remove the valve block during maintenance, the actuator must be controlled to release the pressure to the valve element first before removing the valve block from the actuator. If the valve is open as a default, the valve block can be directly loosened.

[0027] According to a second aspect of the present disclosure, a valve block is provided for controlling the flow of fluid flowing into or out of a solution management system for a bioprocess. The valve block is a single unit having six sides, at least one inlet port disposed on any of the sides of the valve block, at least one outlet port disposed on any of the sides of the valve block, and at least one valve portion fluid-connected to the at least one inlet port and the at least one outlet port, the valve portion being configured to receive a valve element for controlling the fluid passing through the valve block, and at least one integrally formed hose connector portion connected to the at least one inlet port or the at least one outlet port and protruding from the valve block, wherein the at least one hose connector portion extends longitudinally at an angle with respect to the side of the valve block on which the hose connector portion is disposed, and the angle is within a range of 30 to 85 degrees. The angle between the hose connector portion and the side of the valve block on which the hose connector portion is disposed may be referred to as an inclination angle. The valve block having this inclined hose connector portion has been described above in connection with the first aspect of the present disclosure. However, it should be understood that the valve block according to the present invention may include an inclined hose connector portion without including the first channel.

[0028] The hose connector portion is configured to be connected to a hose, which as a result is connected to a fluid source for supplying fluid to the system or a fluid receiver for receiving fluid from the system. The hose connector portion is coaxially arranged with respect to at least one inlet port or at least one outlet port. As described above, the inclined hose connector portion reduces the load on the hose connector portion and also reduces the risk of the hose being twisted. The hose connector portion according to the present disclosure also allows for a more space-efficient arrangement since the connected hose extends near the valve block. This also reduces the risk that an operator steps on the hose, thereby applying an external load to the hose connector portion and ultimately damaging the hose connector portion. Also, when someone steps on the hose connected to the inclined hose connector portion, the stress on the inclined hose connector portion is significantly reduced compared to a straight hose connector portion. Having a hose connector portion integrally formed instead of a separate hose connector portion attached to the valve block also reduces the number of joints or couplings and the risk of leakage.

[0029] The inclination angle between the hose connector portion and the side surface on which the hose connector portion is arranged can be between 40 and 65 degrees. If the angle is too small, the hose connector portion may interfere with the fasteners used to attach the valve block to the actuator. Therefore, the angle should be at least 30 degrees, preferably at least 35 degrees, more preferably at least 40 degrees. If the angle is too large, the risk of the hose twisting and damaging the hose connector portion increases. Therefore, the angle should be 85 degrees or less, preferably 75 degrees or less, more preferably 65 degrees or less.

[0030] At least one hose connector portion may extend downward or upward. If the valve block is positioned so that its outermost side is essentially vertical, the hose connector portion may be positioned to incline downward or upward. Downward inclination may be advantageous when the hose is connected to the valve block from below. The weight of the hose and gravity cause the hose to drop towards the floor, and therefore the load on the hose connector portion is downward. Inclining the hose connector portion downward reduces the risk of the hose twisting and damaging the hose connector portion. If the hose is connected to the valve block from above, the hose connector portion can be appropriately inclined upward to reduce the load on the hose connector portion and reduce the risk of the hose twisting. It should be understood that the hose connector portion may be inclined laterally or in any direction at an angle between 30 and 85 degrees.

[0031] The valve block includes a third channel extending from at least one inlet port or at least one outlet port where the hose connector portion is located. This third channel has a slope at an angle similar to the inclination angle of the hose connector portion. In this way, the flow of fluid into or out of the valve block is improved. At least the portion of the third channel closest to the inlet port or outlet port may have a slope at an angle similar to the inclination angle of the hose connector portion. If the hose connector portion is located at at least one outlet port and slopes downward, and therefore the third channel has a downward slope, the drainage of the system is improved.

[0032] The inner diameter of the hose connector portion can be between 2 and 21 millimeters. Preferably, the inner diameter is greater than 6 millimeters. In some examples, the inner diameter of the hose connector portion is one of 3, 6, 10, 14, and 20.4 millimeters. A hose connector portion with a smaller inner diameter will result in a hose with a similarly smaller inner diameter, which may be less prone to twisting. Therefore, a smaller inner diameter hose connector portion can be positioned at a larger inclination angle (smaller slope). However, a smaller inner diameter hose connector portion is more susceptible to damage from loads from the connected hose and external loads. Therefore, the inner diameter of the hose connector portion should be considered when determining the inclination angle of the hose connection portion. Furthermore, the vertical position of the hose connector portion on the valve block can affect the inclination angle. For example, a valve block may have two hose connector portions with the same inner diameter, one positioned above the other. If the connected hose is cascading downwards towards the floor, the load on the upper hose connector (farthest from the floor) will be higher than the load on the lower hose connector (closest to the floor). Therefore, the upper hose connector can be positioned at a smaller angle of inclination (greater slope) than the lower hose connector.

[0033] Therefore, the valve block may comprise at least two hose connector portions, the at least two hose connector portions extending longitudinally at different angles to the individual sides of the valve block on which the hose connector portions are located.

[0034] At least one valve portion may include a recess having a sealing surface configured to receive and contact a valve element in the shape of a membrane or diaphragm.

[0035] A valve block may comprise four or more valve sections fluidly connected to at least one inlet port and at least one outlet port, each valve section configured to receive a valve element for controlling fluid flowing through the valve block, and at least two valve sections fluidly connected by an integrally formed first channel, the first channel changing direction two or more times. The features, details, and advantages of the valve sections and the first channel described in relation to the first aspect of this disclosure are also valid in relation to the second aspect of this disclosure.

[0036] A solution management system for a bioprocess is also provided according to a second aspect of the present disclosure. The system comprises a valve block according to a second aspect of the present disclosure.

[0037] A system according to a second embodiment may further comprise an actuator package having at least one actuator and valve elements connected to each actuator, wherein the valve block is connected to the actuator package such that the valve elements are aligned and sealed between the valve block and the actuators to the valve portion of the valve block. The system may comprise a valve block having any number of valve portions and corresponding valve elements and actuators.

[0038] A system according to a second embodiment may further comprise at least one actuator clamp for clamping at least two actuators together, and the actuator package is mounted to the system by the at least one actuator clamp being connected to a support structure of the system.

[0039] A valve block according to a second embodiment may be attached to an actuator by fasteners.

[0040] The system according to the second embodiment may further comprise a hose connected to at least one hose connector portion.

[0041] It should be understood that all the effects and advantages of the valve block according to the second embodiment are also applicable to the solution management system according to the second embodiment. Furthermore, the features and details of the solution management system for bioprocesses comprising the valve block according to the first embodiment of this disclosure are also valid for the solution management system for bioprocesses comprising the valve block according to the second embodiment of this disclosure.

[0042] This disclosure will become apparent from the following detailed description. The detailed description and specific examples disclose preferred embodiments of this disclosure for illustrative purposes only. Those skilled in the art will understand from the guidance in the detailed description that changes and modifications may be made within the scope of the appended claims.

[0043] The above-mentioned purposes of this disclosure, as well as any additional purposes, features, and advantages, will be better understood by referring to the following exemplary and non-limiting detailed description of exemplary embodiments of this disclosure in conjunction with the accompanying drawings. [Brief explanation of the drawing]

[0044] [Figure 1a] A schematic valve block for controlling the flow of fluids into or out of a solution management system for a bioprocess, as illustrated by an example of this disclosure, is shown. [Figure 1b] A schematic valve block for controlling the flow of fluids into or out of a solution management system for a bioprocess, as illustrated by an example of this disclosure, is shown. [Figure 2] A schematic valve block for controlling the flow of fluids into or out of a solution management system for a bioprocess, as illustrated by an example of this disclosure, is shown. [Figure 3] A schematic diagram of the valve block is shown in the example provided in this disclosure. [Figure 4] A schematic diagram of the valve block is shown in the example provided in this disclosure. [Figure 5a]A schematic valve block for controlling the flow of fluids into or out of a solution management system for a bioprocess, as illustrated by the present disclosure, is shown. [Figure 5b] A schematic valve block for controlling the flow of fluids into or out of a solution management system for a bioprocess, as illustrated by the present disclosure, is shown. [Figure 6] An example of this disclosure shows a valve block for controlling the flow of fluids into or out of a solution management system for a bioprocess. [Figure 7a] This disclosure provides details of a solution management system for bioprocesses, as illustrated by an example. [Figure 7b] This disclosure provides details of a solution management system for bioprocesses, as illustrated by an example. [Figure 8a] This disclosure illustrates a solution management system for bioprocesses. [Figure 8b] This disclosure illustrates a solution management system for bioprocesses. [Modes for carrying out the invention]

[0045] Next, the Disclosure will be described with reference to the accompanying drawings illustrating preferred exemplary embodiments thereof. However, the Disclosure may be embodied in other forms and should not be construed as being limited to the embodiments disclosed herein. The disclosed embodiments are provided solely to fully convey the scope of the Disclosure to those skilled in the art.

[0046] It should be understood that the terms used herein are intended solely to describe and not to limit specific embodiments. Note that the articles “a,” “an,” “the,” and “said” used herein and in the appended claims are intended to imply the presence of one or more elements unless explicitly indicated otherwise by context. Therefore, for example, a reference to “a unit” or “the unit” may include several devices, etc. Furthermore, the terms “comprising,” “including,” and “containing,” and similar expressions, are intended to be open-ended transitional terms that exclude the possibility of additional elements or steps.

[0047] Figures 1a and 1b schematically illustrate a valve block 100 for controlling the flow of fluid into or out of a solution management system for a bioprocess according to an example of the present disclosure. Figure 1a shows a portion of the front of the valve block 100, and Figure 1b is a side view of the valve block 100. The valve block 100 is a single unit and is therefore formed as a single unit. The valve block comprises at least one inlet port 10, at least one outlet port 20, and four or more valve sections 30 fluid-connected to at least one inlet port 10 and at least one outlet port 20. In this example, the valve block 100 shows two inlet ports 10 and three outlet ports 20. Although only one valve section 30 is shown, the valve block 100 in this example comprises five valve sections 30. Each valve section 30 is configured to receive a valve element (not shown) for controlling the fluid flowing through the valve block 100. At least two valve sections 30 are fluidly connected by an integrally formed first channel 40, the first channel changing direction two or more times.

[0048] The first channel 40 may have a substantially constant cross-sectional area. Therefore, the cross-sectional area of ​​the first channel 40 may remain essentially the same along its extension, even when the direction is changed.

[0049] Figure 1a shows a valve section 30 having a recess 34 with a sealing surface 36 configured to receive and contact a valve element (see Figure 7a). The valve section 30 of the valve block 100 further comprises two or more ports 31 connected to channels within the valve block 100, and a seat 33 between the ports 31.

[0050] The valve block 100 may be manufactured by additive manufacturing, or by molding or casting.

[0051] Figure 2 schematically shows a valve block 100 for controlling the flow of fluid into or out of a solution management system for a bioprocess according to an example of the present disclosure. The valve block 100 may be configured as disclosed in Figures 1a and 1b. Figure 2 shows a front cross-sectional view of the valve block 100, in this example the valve block comprises eight valve sections 30.

[0052] In this example, the first channel 40 is positioned to fluidly connect two diagonally positioned valve sections 30 within the valve block 100. Furthermore, the first channel 40 fluidly connects adjacent valve sections 30, thereby directly connecting five valve sections 30 through the first channel 40.

[0053] The first channel 40 comprises at least two curved sections 44 that change the direction of the first channel 40 at least twice. In this example, the curved sections 44 are configured to provide essentially a 90-degree change of direction. The first channel 40 is separated by channel walls 42 having a thickness between 1.6 and 5 millimeters. The thickness of the channel walls 42 of the first channel may vary along the extension of the first channel 40. The channel walls 42 may be continuous along the longitudinal extension of the first channel 40. The inner diameter D of the first channel 40 may be between 2 and 21 millimeters. The inner diameter D is preferably greater than 6 millimeters. If the first channel 40 has a non-circular cross-sectional shape, the first channel 40 will have a shape and / or size corresponding to an inner diameter between 2 and 21 millimeters.

[0054] The valve block 100 may further include a second channel 50. The second channel 50 may be configured similarly to the first channel 40, and therefore its direction may be changed two or more times. Alternatively, the second channel 50 may be configured differently from the first channel 40. In an example not shown, the first channel 40 and the second channel 50 extend into different planes within the valve block 100 and pass through each other without intersecting.

[0055] Figure 3 schematically shows details of a valve block 100 according to an example of the present disclosure. The valve block 100 may be configured as disclosed in Figures 1 and 2. In this example, at least one curved section 44 of the first channel 40 is configured such that the radius of curvature R changes along at least a portion of the length of the curved section 44. This is shown in Figure 3, where the radius R1 at a first position of the curved section 44 is different from the radius R2 at a second position along the curved section 44 and the radius R3 at a third position of the curved section 44. The radius of curvature R of at least one curved section 44 may change while maintaining a constant cross-sectional area A of the first channel 40. In this way, sharp bends and corners can be avoided and a continuous flow of fluid within the channel can be achieved.

[0056] Figure 4 schematically shows details of a valve block 100 according to an example of the present disclosure. In this example, at least one curved section 44 of the first channel 40 has an inner cross-sectional shape that changes along at least a portion of the length of the curved section 44. Thus, the first channel 40 may have a cross-sectional shape that changes along at least a portion of the length of the first channel 40. The first channel 40 may have a specific cross-sectional shape in the substantially straight section of the first channel 40 and a different cross-sectional shape in the curved section 44. The cross-sectional shape may change while maintaining a constant cross-sectional area A within the curved section 44. Furthermore, smoother flow, pressure drop, etc., can also be achieved by providing one or more variable cross-sectional shapes and / or variable curvatures of the fluid channel(s).

[0057] Figures 5a and 5b schematically illustrate a valve block 100 for controlling the flow of fluid into and / or out of a solution management system for a bioprocess according to an example of the present disclosure. The valve block 100 is a single unit having six sides 110 and comprises at least one inlet port 10 located on any of the sides 110 of the valve block 100, at least one outlet port 20 located on any of the sides 110 of the valve block 100, and at least one valve section 30 fluid-connected to the at least one inlet port 10 and the at least one outlet port 20, wherein the valve section 30 is configured to receive a valve element (see Figure 7a) for controlling the fluid flowing through the valve block 100. The valve block 100 further comprises at least one integrally formed hose connector portion 60 protruding from the valve block 100 and connected to at least one inlet port 10 or at least one outlet port 20, wherein the at least one hose connector portion 60 extends longitudinally at an angle α with respect to the side surface 110 of the valve block 100 on which the hose connector portion is located, and the angle α is in the range of 30 to 85 degrees.

[0058] The angle α between the hose connector portion 60 and the side surface 110 of the valve block 100 on which the hose connector portion is located may be called the inclination angle, and a hose connector portion 60 located at this angle α may be called an inclined hose connector portion 60. The valve block 100 may also include a hose connector portion 70, the hose connector portion 70 extending essentially perpendicular to the side surface 110 of the valve block 100 on which the hose connector portion 70 is located. Such a hose connector portion 70 may be called a straight hose connector portion 70. In the figure, two inclined hose connector portions 60 and one straight hose connector portion 70 are shown, but the valve block 100 may include any number of hose connector portions 60, 70.

[0059] The angled hose connector portion 60 is configured to connect to a hose, which in turn connects to a fluid source for supplying fluid to the system or a fluid receiver for receiving fluid from the system. The hose connector portion 60 is coaxially positioned to at least one inlet port 10 or at least one outlet port 20. The angled hose connector portion 60 reduces the load on the hose connector portion 60 and also reduces the risk of the hose twisting.

[0060] The inclination angle α between the hose connector portion 60 and the side surface 110 on which the hose connector portion is located may be between 40 and 65 degrees. If the angle α is too small, the hose connector portion 60 may interfere with the fastener used to attach the valve block 100 to the system. Therefore, the angle α should be at least 30 degrees, preferably at least 35 degrees, and more preferably at least 40 degrees. If the angle α is too large, the hose may twist, increasing the risk of damaging the hose connector portion 60. Therefore, the angle α should be 85 degrees or less, preferably 75 degrees or less, and more preferably 65 degrees or less.

[0061] Figure 5a shows a downwardly extending inclined hose connector portion 60, and Figure 5b shows an upwardly extending hose connector portion 60. However, it should be understood that the hose connector portion 60 may be inclined laterally or in any direction at an angle between 30 and 85 degrees.

[0062] Figure 6 schematically shows a valve block 100 for controlling the flow of fluid into or out of a solution management system for a bioprocess according to an example of the present disclosure. The valve block 100 may be configured as disclosed in Figure 5a or Figure 5b. The valve block 100 further comprises at least two valve sections 30 fluid-connected by an integrally formed first channel 40, the first channel changing direction two or more times. The first channel 40 may have a substantially constant cross-sectional area. Thus, the cross-sectional area of ​​the first channel 40 may be essentially the same along the extension of the first channel 40, even when changing direction.

[0063] The valve block 100 may be manufactured by additive manufacturing, or by molding or casting.

[0064] Figure 6 also shows the inner diameter HCd of the hose connector portion 60, which can be between 2 and 21 millimeters. The inner diameter HCd is preferably greater than 6 millimeters. The inner diameter HCd may vary along the longitudinal extension of the hose connector portion 60. The valve block 100 in this example also includes a third channel 55 extending from at least one outlet port 20 in which the hose connector portion 60 is located. This third channel 55 may have a slope at an angle similar to the inclination angle α of the hose connector portion 60. In this way, the flow of fluid out of the valve block 100, and therefore drainage, is improved. The third channel 55 may have a slope at an angle different from the inclination angle α of the hose connector portion 60. As an example, the third channel 55 may have a downward slope, preferably a gentler slope than that of the hose connector portion 60.

[0065] Each valve section 30 includes a recess 34 having a sealing surface 36 configured to receive and contact a valve element in the shape of a membrane or diaphragm (see Figure 7a). The valve section 30 of the valve block 100 further includes two or more ports 31 connected to channels within the valve block 100, and a seat 33 between the ports 31.

[0066] Figures 7a and 7b show details of a solution management system 200 for a bioprocess according to an example of the present disclosure. The system 200 comprises a valve block 100 as disclosed in any one of Figures 1 to 6. It should be understood that the valve block 100 in these figures may have an inclined hose connector portion 60, or it may have a straight hose connector portion 60, or it may not have a hose connector portion 60 at all.

[0067] The system 200 further comprises an actuator package 300 having at least one actuator 310, and a valve element 32 connected to at least one actuator 310. The number of actuators 310 and valve elements 32 in each actuator package 300 may depend on the number of valve sections 30 of the valve block 100. In these figures, for clarity, only two actuators 310 are shown. Figure 7a shows an exploded view of the components of the system 200, and Figure 7b shows the same components in an assembled and connected state. The valve block 100 is connected to the actuator package 300 such that the valve element 32 is aligned with the valve section 30 of the valve block 100 and seals the valve section. Thus, the valve element 32 is positioned between the valve block 100 and the actuator 310. The valve element 32 may be a membrane or diaphragm and is positioned between the individual actuator 310 and the valve block 100. In the assembled state, the valve element 32 is positioned in a recess 34 of the valve section 30 and contacts the sealing surface 36. The actuator 310 is controlled to move the central portion of an individual valve element 32 toward or away from the valve portion 30 of the valve block 100 in order to close or open the valve. To close the valve, the central portion of the valve element 32 is pressed against the valve portion 30 of the valve block 100 so as to abut against the seat 33 of the valve portion 30. In this way, the fluid is prevented from passing between the two ports 31 of the valve portion 30. To open the valve, the pressure is released, thereby preventing the valve element 32 from abutting against the seat 33 of the valve portion 30. The system 200 may be configured so that all valves of the valve block 100 are closed by default.

[0068] The actuator package 300 may further comprise at least one actuator clamp 320 that holds at least one actuator 310. In this figure, the actuator clamp 320 clamps at least two actuators 310 together. The actuator package 300 is mounted to system 200 by at least one actuator clamp 320 being connected to a support structure (not shown) of system 200. The actuator clamp 320 facilitates handling several actuators 310 simultaneously and thus allows several actuators 310 to be mounted to system 200 in a simple manner. The actuator clamp 320, and therefore the actuator package 300, may be connected to the support structure to allow lateral movement of the actuator package 300. This increases the tolerance and thus facilitates the mounting of the actuator package 300 and the connection of the valve block 100.

[0069] When assembling the system 200, the actuators 310 of each actuator package 300 are first clamped together by at least one actuator clamp 320. The actuator packages 300 are then mounted by connecting the actuator clamps 320 to the support structure of the system 200. Subsequently, the valve block 100 is aligned with the actuator package 300 and connected to the actuator 310. The valve block 100 may be attached to the actuator by fasteners 330 as shown in Figure 7a. The fasteners 330 are appropriately bolts or screws. The valve block 100 is positioned so that at least one side faces outward away from the system 200 and is therefore easily accessible from outside the system 200. In the system 200 disclosed in these figures, the valve elements 32 are accessed by removing the entire valve block 100 by detaching it from the corresponding actuator 310 (by loosening the screws). Since the actuator package 300 is connected to the support structure via the actuator clamp 320, the valve block 100 can be removed without affecting the stability of the actuator package 300. Therefore, significant time savings can be achieved during maintenance / service, especially if the system 200 includes many such easily removable valve blocks 100 (for example, in one actual embodiment, the system has 10 such valve blocks of different sizes). In one experimental test example, service engineers found that removing such valve blocks instead of actuators reduced the service time per valve block from 45 minutes to 15 minutes.

[0070] Figures 8a and 8b illustrate a solution control system 200 for a bioprocess according to an example of the present disclosure. The system 200 comprises at least one valve block 100, as disclosed in any one of Figures 1 to 6, and a corresponding actuator package 300, as disclosed in Figures 7a and 7b. In these examples, the system 200 comprises five valve blocks 100 having two, four, or six inlet ports 10 / outlet ports 20 facing outwards. It should be understood that the inlet ports 10 and outlet ports 20 shown in the figures are merely examples, and an inlet port 10 can be an outlet port 20, and vice versa. In Figure 8a, the system 200 comprises an outer housing 201 enclosing the other components of the system 200.

[0071] Various solutions are introduced into the system 200 through the inlet port 10 of the valve block 100. These solutions may include, for example, various buffers, water, acids, salts, bases, and additives. The system 200 may, for example, have at least one buffer solution inlet, one water inlet, one base inlet, one acid inlet, and one additive inlet. Valves formed by the valve block 100 and the actuator package 300 control the flow of solutions into and out of the system 200. One or more pumps 204 are configured to draw fluid from the inlet port 10 through the valve block 100 and then pump the drawn fluid into the system 200 through the pump outlet piping / channel to generate fluid displacement within the piping / channel. The system 200 may include at least one mixer zone (not shown) for mixing the solutions from the inlet port 10. The at least one mixer zone may be, for example, a static mixer or a mixing junction such as a T-junction or a Y-junction.

[0072] The solution characteristics unit 207 is located in the mixer zone, fluid-connected to it. The solution characteristics unit 207 comprises one or more solution characteristics sensors (not shown) configured to detect one or more solution characteristic values ​​of a mixed solution. The one or more solution characteristics sensors may be, for example, one or more pH sensors, one or more conductivity sensors, and / or one or more optical sensors (e.g., UV sensors). The system 200 may further comprise one or more flow sensors and / or one or more pressure sensors and / or one or more temperature sensors. Based on the solution characteristics detected by the one or more solution characteristics sensors, the characteristic values ​​of the mixed solution may be registered in the solution characteristics unit 207. The solution characteristics unit 207 may comprise a processor for receiving such measurements, processing the values, and generating a solution characteristics signal(s) indicating the detected value(s). Such a solution characteristics signal may be generated, for example, when the solution characteristic value(s) deviates from a desired value for a particular solution produced by the system. The solution characteristics signal may include information about the degree of deviation of the characteristic value from the desired value. A signal may or may not be generated if the characteristic value is equal to or within a predetermined margin of deviation from a desired value. The solution characteristic unit / processor may be configured to communicate with a valve connected to an inlet port 10 for buffer / base / acid / salt / water / additives, and / or with a pump 204 to increase / decrease / stop the addition of, for example, a base to the solution being mixed. The processor may be located within / integrated into the system, or it may be located outside / at a distance from the system and (wirelessly) connected to the system. The measured characteristics may be visualized on a monitor (wirelessly) connected to the processor. The monitor may be accessible from outside the system, or it may be located outside / at a distance from the system.

[0073] The system 200 includes at least one outlet port 20 fluidly connected to a solution characteristics unit. The outlet port 20 is positioned to discharge a mixed solution from the solution management system 200. The outlet port 20 may be connected to a solution storage container. Alternatively, the solution management system 200 may be directly connected via the outlet port 20 to, for example, a chromatography system (not shown). In an even more alternative configuration, the solution management system 200 may be integrated into, for example, a chromatography system (not shown).

[0074] Those skilled in the art will understand that this disclosure is not limited to the embodiments described above. For example, many types of easily releasable mechanisms may be provided to enable the rapid release and coupling of the valve block 100 within the system 200. Those skilled in the art will further understand that modifications and variations are possible within the scope of the appended claims. [Explanation of Symbols]

[0075] 10 Entrance Ports 20 Exit Ports 30 Valve section 31 ports 32 valve elements 33 seats 34 recess 36 Sealing surface 40 channels 42 channel wall 44 Curved section 50 channels 55 channels 60 Hose connector section 70 Hose connector section 100 Valve Block 110 Side view 200 Systems, Solution Management Systems 201 Outer Housing 204 Pump 207 Solution Properties Unit 300 Actuator Package 310 Actuator 320 Actuator Clamp 330 zippers A cross-sectional area D Inner diameter HCd inner diameter R radius of curvature R1 radius R2 radius R3 radius α angle, tilt angle

Claims

1. A valve block (100) for controlling the flow of fluid into and / or out of a solution management system for a bioprocess (200), wherein the valve block is a single unit, At least one inlet port (10) and At least one exit port (20), A valve section (30) comprising four or more valve sections (30) fluidly connected to the at least one inlet port (10) and the at least one outlet port (20), wherein each valve section (30) is configured to receive a valve element (32) for controlling the fluid flowing through the valve block (100), Equipped with, At least two valve sections (30) are fluidly connected to each other by an integrally formed first channel (40), the first channel changing direction two or more times, in a valve block (100).

2. The valve block (100) according to claim 1, wherein the first channel (40) has a substantially constant cross-sectional area.

3. The valve block (100) according to claim 1 or 2, wherein the fluid-connected at least two valve portions (30) are arranged diagonally within the valve block (100).

4. The valve block (100) according to any one of claims 1 to 3, wherein all four or more valve sections (30) are fluidly connected to one another.

5. The valve block (100) according to any one of claims 1 to 4, wherein the first channel (40) is separated by a channel wall (42) having a thickness between 1.6 and 5 mm.

6. The valve block (100) according to claim 5, wherein the channel wall (42) of the first channel (40) is continuous along the longitudinal extension of the first channel (40).

7. The valve block (100) according to any one of claims 1 to 6, further comprising a second channel (50), wherein the first channel (40) and the second channel (50) extend into different planes within the valve block (100) and pass through each other without intersecting.

8. The valve block (100) according to any one of claims 1 to 7, wherein the first channel (40) comprises at least two curved portions (44) that change the direction of the first channel (40) at least twice, and at least one curved portion (44) is configured such that the radius of curvature (R) changes along at least a portion of the length of the curved portion (44).

9. The valve block (100) according to claim 8, wherein at least one curved portion (44) of the first channel (40) has an inner cross-sectional shape that changes along at least a portion of the length (CL) of the curved portion (44).

10. The valve block (100) according to any one of claims 1 to 9, wherein each valve portion (30) comprises a recess (34) having a sealing surface (36) configured to receive and contact a valve element (32) in the shape of a membrane or diaphragm.

11. The valve block (100) has six sides (110), At least one integrally formed hose connector portion (60) protruding from the valve block (100) and connected to the at least one inlet port (10) or the at least one outlet port (20). Furthermore, The valve block (100) according to any one of claims 1 to 10, wherein the at least one hose connector portion (60) extends longitudinally at an angle (α) with respect to the side surface (110) of the valve block (100) on which the hose connector portion (60) is located, and the angle (α) is in the range of 30 to 85 degrees.

12. A solution management system (200) for a bioprocess, comprising at least one valve block (100) according to any one of claims 1 to 11.

13. An actuator package (300) having at least four actuators (310), Each actuator (310) is connected to a valve element (32), Furthermore, The system (200) according to claim 12, wherein the valve block (100) is connected to the actuator package (300) such that the valve element (32) is aligned with and sealed to the valve portion (30) of the valve block (100) between the valve block (100) and the actuator (310).

14. The system (200) according to claim 13, wherein the actuator package (300) further comprises at least one actuator clamp (320) for holding at least one actuator (310), and the actuator package (300) is attached to the system (200) by the at least one actuator clamp (320) being connected to a support structure (210) of the system (200).

15. The system (200) according to claim 13 or 14, wherein the valve block (100) is attached to the actuator (310) by fasteners (330).

16. A valve block (100) for controlling the flow of fluids into and / or out of a solution management system (200) for a bioprocess, wherein the valve block is a single unit having six sides (110), At least one inlet port (10) located on one of the sides (110) of the valve block (100), At least one outlet port (20) located on one of the sides (110) of the valve block (100), A valve section (30) is fluid-connected to the at least one inlet port (10) and the at least one outlet port (20), wherein the valve section is configured to receive a valve element (32) for controlling the fluid passing through the valve block (100), At least one integrally formed hose connector portion (60) protruding from the valve block (100) and connected to the at least one inlet port (10) or the at least one outlet port (20), Equipped with, The valve block (100) wherein the at least one hose connector portion (60) extends longitudinally at an angle (α) with respect to the side surface (110) of the valve block (100) on which the hose connector portion (60) is located, and the angle (α) is within the range of 30 to 85 degrees.

17. The valve block (100) according to claim 16, wherein the angle (α) is within the range of 40 to 65 degrees.

18. The valve block (100) according to claim 16 or 17, wherein the at least one hose connector portion (60) extends in a downward or upward direction.

19. The valve block (100) according to any one of claims 16 to 18, wherein the valve block (100) comprises at least two hose connector portions (60), the at least two hose connector portions (60) extending longitudinally at different angles (α) with respect to individual sides (110) of the valve block (100) on which the hose connector portions (60) are located.

20. The valve block (100) according to any one of claims 16 to 19, wherein the at least one valve portion (30) comprises a recess (34) having a sealing surface (36) configured to receive and contact a valve element (32) in the shape of a membrane or diaphragm.

21. A valve block (100) according to any one of claims 16 to 20, comprising four or more valve sections (30) fluidly connected to at least one inlet port (10) and at least one outlet port (20), each valve section configured to receive a valve element (32) for controlling fluid flowing through the valve block (100), wherein at least two valve sections (30) are fluidly connected by an integrally formed first channel (40), the first channel changing direction two or more times.

22. A solution management system (200) for a bioprocess, comprising at least one valve block (100) as described in any one of claims 16 to 21.

23. An actuator package (300) having at least one actuator (310), Each actuator (310) is connected to at least one valve element, Equipped with, The system (200) according to claim 22, wherein the valve block (100) is connected to the actuator package (300) such that the valve element (32) is aligned with and sealed to the valve portion (30) of the valve block (100) between the valve block (100) and the actuator (310).

24. The system (200) according to claim 23, wherein the actuator package (300) further comprises at least one actuator clamp (320) for holding at least one actuator (310), and the actuator package (300) is attached to the system (200) by the at least one actuator clamp (320) being connected to a support structure (210) of the system (200).

25. The system (200) according to claim 24, wherein the valve block (100) is attached to the actuator (310) by fasteners (330).

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