Focused ultrasound processing system for opening and monitoring the cerebral-vascular barrier, and ultrasonic control method for the focused ultrasound processing system for opening and monitoring the cerebral-vascular barrier.

Abstract

A focused ultrasound processing system for opening and monitoring the cerebral blood-vascular barrier according to one embodiment of the present invention may include at least one piezoelectric element comprising a single structure, and a drive module that provides an electrical signal to the at least one piezoelectric element to output ultrasonic energy having at least one resonant frequency among a plurality of resonant frequencies.

Description

Technical Field

[0001] The present invention relates to a focused ultrasound treatment system for opening and monitoring the blood-brain barrier, and an ultrasonic control method of the focused ultrasound treatment system for opening and monitoring the blood-brain barrier.

[0002] The present invention is obtained from research conducted as part of the "Drug Delivery Therapy Technology Development Project" of the Ministry of Health and Welfare of Korea (Project Specific Number: 1465040354, Project Number: HI23C0344000023, Research Project Name: Development of Brain Drug Delivery Technology Using an Externally Worn Ultrasound and Drug Carrier, Project Management Agency: Korea Health Industry Development Institute, Project Implementation Agency: Newmas Co., Ltd., Research Period: April 1, 2023 to December 31, 2027, Contribution Rate: 50%) and the "Startup Growth Technology Development (R&D)" of the Ministry of SMEs and Startups (Project Specific Number: 1425179650, Project Number: 00261874, Research Project Name: Development of a Multi-Channel Focused Ultrasound Device for Patient Customized Blood-Brain Barrier Adjustment, Project Management Agency: Small and Medium Enterprise Technology Information Promotion Agency, Project Implementation Agency: Newmas Co., Ltd., Research Period: June 1, 2023 to May 31, 2026, Contribution Rate: 50%). In addition, in all aspects of the present invention, there is no property interest of the Korean government.

Background Art

[0003] The blood-brain barrier (BBB) refers to a physiological barrier present in the blood vessels of the brain to separate and protect the brain and the central nervous system. This barrier plays a role in separating the nerve cells inside the brain from the blood.

[0004] On the other hand, the phenomenon that therapeutic drugs for brain diseases cannot sufficiently penetrate into the brain due to the blood-brain barrier is an important problem related to many neurological and medical issues. That is, while the blood-brain barrier plays a role in separating the blood and brain tissue to protect the brain and maintain its safety, it also makes it difficult to effectively deliver therapeutic drugs for brain diseases.

[0005] In recent years, various technologies have been developed and researched to deliver drugs for treating brain diseases by crossing the blood-brain barrier. However, these technologies have various limitations, such as limited or temporary effects, safety issues, and difficulties in precise targeting.

[0006] Therefore, there is a need for technology that can not only efficiently and safely control the opening of the blood-brain barrier, but also monitor the entire process to overcome the aforementioned problems and effectively deliver drugs for treating brain diseases into the brain. [Overview of the Initiative] [Problems that the invention aims to solve]

[0007] The technical problem that this invention aims to solve is to open the blood-brain barrier by outputting (or irradiating) ultrasonic energy having one of the resonant frequencies of a plurality of ultrasonic piezoelectric elements.

[0008] Furthermore, the technical problem that this invention aims to solve is to receive an acoustic cavitation signal from an object to which ultrasonic energy is output (or irradiated), and to monitor in real time the degree of opening of the blood-brain barrier (or the location and behavior of the acoustic cavitation generating substance) and the focal position of the ultrasonic energy (or the location in the brain where the opening of the blood-brain barrier occurs).

[0009] Furthermore, the technical problem that the present invention aims to solve is to acquire a skull image of a target body by outputting ultrasonic energy having one of the resonant frequencies of a plurality of ultrasonic piezoelectric elements over the entire period of opening of the blood-brain barrier. [Means for solving the problem]

[0010] A focused ultrasound processing system for opening and monitoring the cerebral blood-vascular barrier according to one embodiment of the present invention may include at least one piezoelectric element comprising a single structure, and a drive module that provides an electrical signal to cause the at least one piezoelectric element to output ultrasonic energy having a resonant frequency of any of a plurality of resonant frequencies or ultrasonic energy having at least two or more resonant frequencies.

[0011] Furthermore, in one embodiment of the present invention, the at least one piezoelectric element may be composed of one or more materials in which the member interacting with the ultrasonic energy is made.

[0012] Furthermore, the at least one piezoelectric element according to one embodiment of the present invention can output ultrasonic energy to a target object or an acoustic cavitation generating substance administered to the target object.

[0013] Furthermore, the at least one piezoelectric element according to one embodiment of the present invention can receive an acoustic cavitation signal that is reflected by the target object or generated by the acoustic cavitation phenomenon of the acoustic cavitation generating material.

[0014] Furthermore, the plurality of resonant frequencies according to one embodiment of the present invention may include a first resonant frequency and a second resonant frequency having a frequency value lower than the first resonant frequency.

[0015] Furthermore, the focused ultrasound processing system for opening and monitoring the cerebrovascular barrier according to one embodiment of the present invention may further include a determination module for analyzing the acoustic cavitation signal to generate an image of the target object or to determine the location or behavior of the acoustic cavitation generating substance.

[0016] Furthermore, the judgment module according to one embodiment of the present invention can generate the image by analyzing the acoustic cavitation signal generated when the first ultrasonic energy having the first resonant frequency is reflected by the target object.

[0017] Furthermore, the judgment module according to one embodiment of the present invention can generate the image by measuring the TOF (Time Of Flight), which is the period between the time when the first ultrasonic energy is output by the at least one piezoelectric element and the time when the acoustic cavitation signal is detected.

[0018] Furthermore, the at least one piezoelectric element according to one embodiment of the present invention can output a second ultrasonic energy having the second resonant frequency, thereby opening the target object.

[0019] Furthermore, in one embodiment of the present invention, the target object may be the blood-brain barrier, and the acoustic cavitation generating substance may be microbubbles located in the vicinity of the target object.

[0020] Furthermore, the judgment module according to one embodiment of the present invention extracts a frequency component corresponding to n / 2 of the second resonance frequency from the acoustic cavitation signal to determine the behavior of the acoustic cavitation generating material, where n can be a natural number other than 2.

[0021] Furthermore, the determination module according to one embodiment of the present invention can determine the location of the acoustic cavitation generating material by analyzing the acoustic cavitation signal generated by the second ultrasonic energy having the second resonant frequency.

[0022] Furthermore, each of the at least one piezoelectric element according to one embodiment of the present invention can perform at least two of the following functions: a first function for outputting ultrasonic energy to generate an image of the target object; a second function for outputting ultrasonic energy to open the target object; a third function for analyzing the acoustic cavitation signal to determine the behavior of the acoustic cavitation generating material; and a fourth function for analyzing the acoustic cavitation signal to simultaneously determine the position and behavior of the acoustic cavitation generating material.

[0023] Furthermore, in an ultrasonic control method for a focused ultrasonic processing system for opening and monitoring the cerebrovascular barrier, driven by at least one processor according to one embodiment of the present invention, the method may include the steps of: providing an electrical signal to the at least one processor so that ultrasonic energy having at least one or more resonant frequencies among a plurality of resonant frequencies is output; and receiving the electrical signal from the at least one processor and outputting the ultrasonic energy having the resonant frequencies to a target object and an acoustic cavitation generating substance administered to the target object.

[0024] Furthermore, the present invention may include a computer-readable recording medium on which a program for executing an ultrasonic control method for a focused ultrasound processing system for opening and monitoring the cerebral-vascular barrier according to one embodiment of the present invention is recorded. [Effects of the Invention]

[0025] A focused ultrasound processing system for opening and monitoring the cerebral-vascular barrier according to one embodiment of the present invention, and a control method for the focused ultrasound processing system for opening and monitoring the cerebral-vascular barrier, can acquire images of the skull by utilizing the high-frequency resonant frequency of a single-structure piezoelectric element.

[0026] In addition, a focused ultrasound treatment system for opening and monitoring the cerebrovascular barrier according to an embodiment of the present invention, and a control method of the focused ultrasound treatment system for opening and monitoring the cerebrovascular barrier can open the cerebrovascular barrier by utilizing the resonance frequency in the low-frequency region of a single-structured piezoelectric element.

[0027] In addition, a focused ultrasound treatment system for opening and monitoring the cerebrovascular barrier according to an embodiment of the present invention, and a control method of the focused ultrasound treatment system for opening and monitoring the cerebrovascular barrier can analyze the acoustic cavitation signal generated by ultrasonic energy in real time, determine and monitor the focusing position of ultrasonic energy (or the position of the brain where the opening of the cerebrovascular barrier occurs) and the degree of opening of the cerebrovascular barrier (or the position and behavior of the acoustic cavitation generating substance).

Brief Description of the Drawings

[0028] [Figure 1] FIG. 1 is a diagram related to a focused ultrasound treatment system for opening and monitoring the cerebrovascular barrier according to an embodiment of the present invention. [Figure 2] FIG. 2 is a diagram related to the frequency region band of a single piezoelectric element according to an embodiment of the present invention. [Figure 3] FIG. 3 is an example related to the process of acquiring an image of the skull by utilizing the resonance frequency in the high-frequency region according to an embodiment of the present invention. [Figure 4] FIG. 4 is another example related to the process of acquiring an image of the skull by utilizing the resonance frequency in the high-frequency region according to an embodiment of the present invention. [Figure 5] FIG. 5 is a diagram related to the adjustment of the brain target position of a piezoelectric element based on video alignment according to an embodiment of the present invention. [Figure 6] FIG. 6 is a diagram related to the monitoring process of the opening of the cerebrovascular barrier and the position and behavior of the acoustic cavitation generating substance by utilizing the ultrasonic energy in FIG. 2. [Figure 7]Figure 7 is a flowchart illustrating an ultrasonic control method for a focused ultrasound processing system for opening and monitoring the cerebral-vascular barrier according to one embodiment of the present invention. [Modes for carrying out the invention]

[0029] Hereinafter, with reference to the attached drawings, each embodiment of the present invention will be described in detail so that it can be easily implemented by those skilled in the art in which the present invention pertains. The present invention can be implemented in various forms and is not limited to the embodiments described herein.

[0030] To clearly illustrate the present invention, irrelevant parts have been omitted, and the same or similar reference numerals are used throughout the specification for identical or similar components. Therefore, the aforementioned reference numerals can also be used in other drawings.

[0031] Furthermore, the dimensions and thicknesses of each component shown in the drawings are arbitrarily indicated for the sake of explanation, and the present invention is not necessarily limited to those shown. In some cases, the thickness may be exaggerated in the drawings to clearly represent multiple layers or regions.

[0032] Furthermore, when the description states that they are "identical," it may also imply that they are "substantially identical." In other words, it means an degree of identicality that a person skilled in the art would understand. In other expressions as well, the word "substantially" may be omitted.

[0033] Furthermore, where a description states that a part "includes" a certain component, unless otherwise specified, this means that other components may be included, rather than being excluded. As used herein, "~part" refers to a unit that processes at least one function or operation, and may mean, for example, a software, FPGA, or hardware component. The function provided by "~part" may be performed separately by multiple components or integrated with other additional components. "~part" as used herein is not necessarily limited to software or hardware, and may be configured on an addressable recording medium and may be configured to be executed by one or more processors. Embodiments of the present invention will be specifically described below with reference to the drawings.

[0034] Figure 1 is a diagram relating to a focused ultrasound processing system for opening and monitoring the cerebral-vascular barrier according to one embodiment of the present invention.

[0035] A focused ultrasound processing system 1 for opening and monitoring the cerebral-vascular barrier according to one embodiment of the present invention may include a focused ultrasound processing device 10, a drive module 20, and a decision module 30.

[0036] However, it goes without saying that the focused ultrasound processing system 1 for opening and monitoring the cerebral-vascular barrier may be composed of fewer or more components than those shown in Figure 1.

[0037] For example, the focused ultrasound processing system 1 for opening and monitoring the cerebrovascular barrier may further include a power supply unit (not shown) for providing power, an output time control unit (not shown) for setting or controlling the output time of focused ultrasound energy, a matching circuit (Resonant Circuit, not shown) for adjusting to the resonant frequency so that focused ultrasound energy is output at any resonant (or center) frequency set by the user, and a display unit (or display device, not shown) for visually confirming the results of frequency analysis.

[0038] The focused ultrasonic processing apparatus 10, the drive module 20, and the decision module 30 are each composed of at least one processor, or can be driven by such processor.

[0039] The focused ultrasonic device 10 may be in the form of a helmet, but the present invention is not limited thereto. That is, the focused ultrasonic device 10 can be manufactured in various forms that can cover the head (or skull) of the target body.

[0040] The focused ultrasonic device 10 may include at least one piezoelectric element 11 (see Figures 2a and 2b). In this case, at least one piezoelectric element 11 may be installed on the inner surface (or lower surface) of the focused ultrasonic device 10 facing the head (or skull) of the target body.

[0041] At least one piezoelectric element 11 may be arranged on the lower surface of the focused ultrasonic device 1 at predetermined intervals from each other. In this case, the arrangement structure of the piezoelectric elements 11 can vary. For example, at least one piezoelectric element may be arranged radially with respect to the center of the focused ultrasonic device 1.

[0042] Each of at least one piezoelectric element 11 can be composed of a single structure (see Figure 2b). That is, the piezoelectric element 11 may be a single-element form formed from only one of the structures, rather than being composed of a combination of different elements.

[0043] The piezoelectric element 11 may be composed of quartz, ceramic materials (for example, lead zirconate titanate (or lead zirconate titanate, PZT, lead zironate titanate)), polymer materials, etc., but the present invention is not limited thereto.

[0044] The piezoelectric element 11 may consist of at least one of the materials described above, which interacts with the ultrasonic energy (or focused ultrasonic energy) described later. For example, the piezoelectric element 11 may be composed of any one of the materials described above, or it may be composed of a material which is a mixture of at least two of the materials described above.

[0045] Each of the at least one piezoelectric element 11 can output ultrasonic energy to at least one of the target object and acoustic cavitation generating material based on an electrical signal provided by the drive module 20, which will be described later.

[0046] Specifically, as described below, since the acoustic cavitation generating material can be located near the target object (e.g., the blood-brain barrier), the ultrasonic energy output from at least one piezoelectric element 11 can reach not only the target object but also the acoustic cavitation generating material.

[0047] Furthermore, each of the at least one piezoelectric element 11 is capable of receiving (or detecting) an acoustic cavitation signal (hereinafter referred to as an acoustic signal) generated by the acoustic cavitation phenomenon of the acoustic cavitation generating material.

[0048] Specifically, the target object may be pre-injected with an acoustic cavitation generating substance (e.g., microbubbles). After being injected into the target object, the microbubbles, which are the acoustic cavitation generating substance, can be located near the blood-brain barrier (BBB).

[0049] Each of the at least one piezoelectric element 11 can output ultrasonic energy based on an electrical signal, directed towards at least one of the target objects (e.g., the blood-brain barrier) and at least one of the pre-injected microbubbles.

[0050] Microbubbles supplied with ultrasonic energy can generate acoustic signals through the acoustic cavitation phenomenon, and each of the at least one piezoelectric element 11 can receive (or detect) such acoustic signals.

[0051] The drive module 20 can provide an electrical signal so that ultrasonic energy having at least one resonant frequency among a plurality of resonant frequencies is output simultaneously or sequentially by at least one piezoelectric element 11.

[0052] In this case, the multiple resonant frequencies may include a first resonant frequency (or a resonant frequency in the high-frequency range) and a second resonant frequency (or a resonant frequency in the low-frequency range) that has a lower frequency value than the first resonant frequency. In this case, the frequency values ​​of the first and second resonant frequencies can be set in various ways by the user beforehand.

[0053] The drive module 20 can provide an electrical signal to at least one piezoelectric element 11 so that it outputs ultrasonic energy having at least one resonant frequency among the first resonant frequency and the second resonant frequency, either simultaneously or sequentially, according to user settings or preset conditions.

[0054] For example, the drive module 20 can provide an electrical signal (hereinafter referred to as the first electrical signal) to any pre-specified piezoelectric element 11, and the piezoelectric element 11 can output ultrasonic energy having a first resonant frequency (hereinafter referred to as the first ultrasonic energy) to at least one of the target object and acoustic cavitation generating material based on the first electrical signal.

[0055] Furthermore, the drive module 20 can provide an electrical signal (hereinafter referred to as the second electrical signal) to any piezoelectric element 11, and the piezoelectric element 11 can output ultrasonic energy having a second resonant frequency (hereinafter referred to as the second ultrasonic energy) to at least one of the target object (or blood-brain barrier) and acoustic cavitation generating material based on the second electrical signal.

[0056] Furthermore, the drive module 20 can provide an electrical signal to any or more piezoelectric elements 11, and the piezoelectric elements 11 can simultaneously or sequentially output a first ultrasonic energy having a first resonant frequency and a second ultrasonic energy having a second resonant frequency to at least one of the target object and acoustic cavitation generating material based on the electrical signal.

[0057] At this time, the target body (or the blood-brain barrier) to which the second ultrasonic energy is supplied may be opened. By opening the blood-brain barrier, the desired drug can flow into the brain.

[0058] The judgment module 30 can analyze the acoustic signal to generate an image of the target object, or determine the focal position of the ultrasonic energy (or the location of the brain where the cerebral-vascular barrier opens, or the current location or behavior of the acoustic cavitation generating substance, or the degree of cerebral-vascular barrier opening).

[0059] Specifically, the judgment module 30 can analyze an acoustic signal generated when a first ultrasonic energy having a first resonant frequency is reflected from a target object, and generate an image (for example, an image of the target object's skull).

[0060] In this case, the judgment module 30 can generate an image by measuring the TOF (Time of Flight), which is the period between the time when the first ultrasonic energy is output by at least one piezoelectric element 11 and the time when it is reflected back and detected.

[0061] Furthermore, the judgment module 30 can analyze the acoustic signal generated when a second ultrasonic energy having a second resonant frequency is reflected from the target object to determine the focal position of the ultrasonic energy (or the location of the brain where the cerebral-vascular barrier opens, or the current location or behavior of the acoustic cavitation generating substance, or the degree of cerebral-vascular barrier opening).

[0062] Specifically, the judgment module 30 can extract frequency components from the acoustic signal that correspond to n / 2 times the second resonant frequency (where n is a natural number other than 2), namely subharmonics, harmonics, and ultraharmonics components, and determine the behavior of the acoustic cavitation generating material.

[0063] The behavior of acoustic cavitation generating materials refers to the size, shape, and intensity of microbubbles that vibrate due to ultrasonic energy. The degree to which the blood-brain barrier is opened can be inferred (or judged) from the behavior of acoustic cavitation generating materials.

[0064] Furthermore, the judgment module 30 can analyze (or perform Passive Acoustic Mapping (PAM) on) multiple acoustic signals detected by multiple piezoelectric elements 11 to determine the location (or current location) of the acoustic cavitation generating material.

[0065] On the other hand, each of the at least one piezoelectric element 11 described above can simultaneously or sequentially perform at least two of the following functions: a first function for outputting ultrasonic energy to generate an image of the target object; a second function for outputting ultrasonic energy to open the blood-brain barrier; a third function for analyzing acoustic signals to determine the behavior of acoustic cavitation generating material; and a fourth function for analyzing acoustic signals to simultaneously determine the location and behavior of acoustic cavitation generating material.

[0066] For example, any piezoelectric element 11 can simultaneously or sequentially perform a first function of outputting ultrasonic energy to the skull of a target body in order to acquire an image of the skull, and a third function of analyzing the acoustic signal received from the acoustic cavitation generating material to determine the behavior of the acoustic cavitation generating material.

[0067] Furthermore, any piezoelectric element 11 can simultaneously or sequentially perform a second function of outputting ultrasonic energy to the cerebral-vascular barrier in order to open the cerebral-vascular barrier, and a fourth function of simultaneously determining the location and behavior of the acoustic cavitation generating material by analyzing the acoustic signal received from the acoustic cavitation generating material.

[0068] Figure 2 is a diagram relating to the frequency range of a single piezoelectric element according to one embodiment of the present invention.

[0069] Figure 2a is a view of the lower surface of the focused ultrasonic device 10, Figure 2b is a perspective view of the piezoelectric element, and Figure 2c is a graph relating to the frequency range bands used by at least one piezoelectric element 11 provided in the focused ultrasonic device 10.

[0070] Referring to Figure 2a, a through-hole may be formed in the center of the focused ultrasonic device 10. In this case, at least one piezoelectric element 11 may be arranged radially with a predetermined distance between them from each other, centered on the through-hole.

[0071] As shown above in Figure 1, the piezoelectric element 11 may be composed of a single material or multiple materials (for example, a composite material having different densities) that interact with ultrasonic energy.

[0072] In Figure 2b, the piezoelectric element 11 is shown in a cylindrical shape, but the present invention is not limited to this. That is, the piezoelectric element 11 can be formed in various three-dimensional shapes that can interact with ultrasonic energy.

[0073] Furthermore, each of the multiple piezoelectric elements 11 can perform at least two of the first to fourth functions described in Figure 1. These functions can be pre-configured by the user.

[0074] Furthermore, the drive module 20 can provide a first electrical signal to a piezoelectric element 11 that is pre-configured (or designated) to perform a first function. At this time, the piezoelectric element 11 can output a first ultrasonic energy to the target object having a first resonant frequency (approximately 3000 kHz) in the frequency range shown in Figure 2c.

[0075] Furthermore, the drive module 20 can provide a second electrical signal to a piezoelectric element 11 that is pre-configured (or designated) to perform a second function. At this time, the piezoelectric element 11 can output a second ultrasonic energy having a second resonant frequency (approximately 250 kHz) in the frequency range shown in Figure 2b to at least one of the target object (or blood-brain barrier) and the acoustic cavitation generating material.

[0076] Meanwhile, the piezoelectric element 11, configured to perform a third function, can receive an acoustic signal generated by the acoustic cavitation generating material and provide it to the judgment module 30. The judgment module 30 can analyze the acoustic signal to determine the behavior of the acoustic cavitation generating material by analyzing frequency components (125 kHz, 375 kHz, etc.) corresponding to n / 2 times the second resonant frequency (250 kHz, f2) (i.e., f2 × n / 2, n=1, 3, 5, ...) and frequency components (500 kHz, 750 kHz, ...) corresponding to f2 × n (n=2, 3, 4, ...).

[0077] Multiple piezoelectric elements 11 configured to perform a fourth function can receive multiple acoustic signals generated by the acoustic cavitation generating material and provide them to the decision module 30. Based on the multiple acoustic signals, the decision module 30 can perform Passive Acoustic Mapping and simultaneously determine the location and behavior of the acoustic cavitation generating material.

[0078] Figure 3 shows an example of the process of acquiring an image of the skull using a high-frequency resonant frequency according to one embodiment of the present invention.

[0079] Referring to Figure 3a, the focused ultrasonic device 10 of the present invention can be attached to the head of the target object. In this case, a medium that facilitates the transmission of focused ultrasonic energy can be positioned between at least one piezoelectric element 11 and the head of the target object.

[0080] For example, the medium may be water, but the present invention is not limited thereto. That is, any substance that can minimize the attenuation of ultrasonic energy can be used instead of water.

[0081] Referring together to Figures 1, 3a, and 3b, the drive module 20 can provide a first electrical signal to at least one piezoelectric element 11 that performs a first function in order to acquire a skull image of the target body.

[0082] The piezoelectric element 11 can output a first ultrasonic energy (solid line in Figures 3a and 3b) having a first resonant frequency (approximately 3000 kHz) in the direction of the skull of the target body, based on a first electrical signal.

[0083] The first ultrasonic energy is output from the piezoelectric element 11, reaches the surface of the skull of the target body, is reflected from the surface of the skull (see Figure 3a), and can return to the piezoelectric element 11.

[0084] At this time, the judgment module 30 can measure the time-of-flight (TOF), which is the period between the time when the first ultrasonic energy is output from the piezoelectric element 11 and the time when the first ultrasonic energy reflected back from the surface of the skull is detected, and generate an image of the skull (or a B-mode (Brightness-mode) image, see Figure 3c).

[0085] The judgment module 30 can generate an image of a skull through the process described above, and the user can visually confirm the image through a display unit (or display device) or the like.

[0086] Figure 4 shows another example of the process of acquiring an image of the skull using a high-frequency resonant frequency according to one embodiment of the present invention.

[0087] Referring to Figure 4, unlike in Figure 3, it is possible to acquire an image of the skull of the target body while moving the position of at least one piezoelectric element 11 provided in the focused ultrasound processing device 10.

[0088] Specifically, if it is difficult to obtain an image of the entire skull of a target body using only at least one piezoelectric element 11 provided in the focused ultrasonic device 10 due to constraints such as the area of ​​the focused ultrasonic device 10, segmented images of the skull can be obtained and then combined (or superimposed) to obtain an image of the entire skull.

[0089] For example, at least one piezoelectric element 11 installed at a first position in the focused ultrasonic device 10 can output a first ultrasonic energy having a first resonant frequency (primary output in Figure 4) toward a first region of the skull.

[0090] The piezoelectric element 11 receives the first ultrasonic energy that has been reflected back from the surface of the first region of the skull, and the decision module 30 can generate an image of the first region of the skull using the TOF described above in Figure 3.

[0091] At least one piezoelectric element 11 can be moved to a second position on the focused ultrasonic device 10 by a moving device installed on the focused ultrasonic device 10 or by user operation.

[0092] The moved piezoelectric element 11 can output a first ultrasonic energy having a first resonant frequency toward a second region of the skull (secondary output in Figure 4).

[0093] The piezoelectric element 11 receives the first ultrasonic energy that has been reflected back from the surface of the second region of the skull, and the decision module 30 can generate an image of the second region of the skull using the TOF described above in Figure 3.

[0094] At least one piezoelectric element 11 can be moved to a third position on the focused ultrasonic processing device 10 by a moving device installed on the focused ultrasonic processing device 10 or by user operation.

[0095] Furthermore, the moved piezoelectric element 11 can output a first ultrasonic energy having a first resonant frequency toward a third region of the skull (third-order output in Figure 4).

[0096] The piezoelectric element 11 receives the first ultrasonic energy that has been reflected back from the surface of the third region of the skull, and the decision module 30 can generate an image of the third region of the skull using the TOF described above in Figure 3.

[0097] The judgment module 30 can synthesize and superimpose the images of the first to third regions of the skull generated in the process described above to obtain an image of the entire skull.

[0098] On the other hand, Figure 4 shows a two-dimensional image of a skull, but the present invention is not limited to this. That is, the shape of the skull may be three-dimensional, and it goes without saying that the judgment module 30 can generate a three-dimensional image of the entire skull through the process described above.

[0099] Figure 5 is a diagram relating to the adjustment of the brain target position of a piezoelectric element based on image matching according to one embodiment of the present invention.

[0100] The MRI (or CT) images of the subject may be stored in a database (not shown). That is, the MRI (or CT) images of the subject may be acquired on-site using an MRI device (or CT device, not shown), and these images may be stored in a database.

[0101] The decision module 30 can move the focused ultrasound processing device 10 using images of parts or the whole of the skull shown in Figures 3-4 and MRI images (or CT images) pre-stored in the database, thereby adjusting the brain target position to which the ultrasound energy is focused.

[0102] Specifically, the judgment module 30 can compare and analyze images of a part or the whole of the skull with pre-stored MRI images (or CT images) through an image matching process.

[0103] For example, the judgment module 30 can obtain, through comparative analysis based on the image matching process, the current three-dimensional coordinate values ​​(X, Y, Z) of the focused ultrasonic device 10 at the point where the skull matches to the maximum extent (or the point where the error rate between images (or image matching error rate) is smallest), and the coordinate values ​​(Xf, Yf, Zf) of the focal point of the ultrasonic energy output from the focused ultrasonic device 10 located at those three-dimensional coordinate values ​​(X, Y, Z).

[0104] A moving device (for example, a robotic arm) can adjust the position of the focused ultrasonic device 10 based on the acquired current three-dimensional coordinate values ​​(X, Y, Z) of the focused ultrasonic device 10, and move it to a new position with three-dimensional coordinate values ​​(X1, Y1, Z1).

[0105] The mobile device can take into account the brain lesion target position coordinates (X1f, Y1f, Z1f) acquired by MRI images (or CT images), and can adjust the position of the focused ultrasound processing device 10 from the current three-dimensional coordinates (X, Y, Z) to new three-dimensional coordinates (X1, Y1, Z1) so that the current ultrasound energy focus point coordinates (Xf, Yf, Zf) are located at the brain lesion target position coordinates (X1f, Y1f, Z1f).

[0106] In this case, prior sound field characteristic data of the focused ultrasonic device 10 can be used. Specifically, prior sound field characteristic data refers to data relating to the mutually different focusing characteristics of the ultrasonic energy output according to the position of the focused ultrasonic device 10 relative to the skull of the target body (e.g., installation position, installation angle, etc.), such as the position of the focal point where the ultrasonic energy output from at least one piezoelectric element 11 included in the focused ultrasonic device 10 is fused and focused, the width of the focal point, and the length of the focal point.

[0107] Prior data on the sound field characteristics of the focused ultrasonic device 10 at each position relative to the skull of the target body may be stored in a database beforehand, and a moving device (e.g., a robotic arm) can use the prior data on sound field characteristics to move the focused ultrasonic device 10 or adjust the position of at least one piezoelectric element 11 so that the ultrasonic energy is effectively focused to the target focusing position (X1f, Y1f, Z1f).

[0108] Specifically, the mobile device can move the focused ultrasonic device 10 using the aforementioned sound field characteristic pre-data, or adjust the position of at least one piezoelectric element 11 (for example, by moving the piezoelectric element 11 forward or backward), so that ultrasonic energy is focused to a target focus position (or target focus point) determined through clinical analysis (or MRI images).

[0109] The process of moving the focused ultrasonic device 10 or adjusting the position of at least one piezoelectric element 11 may include the process of moving or rotating at least one piezoelectric element 11 using the moving device.

[0110] Furthermore, the moving device may include a process of increasing or decreasing the distance of the focused ultrasonic device 10 relative to the surface of the skull.

[0111] Furthermore, the moving device may include a process of moving at least one piezoelectric element 11 included in the focused ultrasonic processing device 10 so that its distance from the surface of the skull approaches or moves away from the surface of the skull, with the surface of the skull as the reference point.

[0112] Through the process described above, ultrasound energy can be focused on the brain lesion target, and the judgment module 30 can acquire new three-dimensional coordinate values ​​(X1, Y1, Z1) and three-dimensional target focus point (or brain lesion target point (X1f, Y1f, Z1f)) of the focused ultrasound processing device 10 adjusted through the process described above.

[0113] Figure 6 shows the process of monitoring the location and behavior of acoustic cavitation-generating substances and the opening of the cerebral-vascular barrier using the ultrasonic energy shown in Figure 2.

[0114] Referring together to Figures 2 and 6a, based on a first electrical signal provided by the drive module 20, at least one piezoelectric element 11 performing a first function can output a pulse A of ultrasonic energy at a first resonant frequency (3000 kHz) in the high-frequency range.

[0115] At least one piezoelectric element 11 can detect pulse B of ultrasonic energy that has been reflected back from the skull of the target body. In this case, the time interval between the time when pulse A is output from at least one piezoelectric element 11 and the time when pulse B is detected by the piezoelectric element 11 may be several milliseconds.

[0116] The decision module 30 can generate an image of the skull by measuring the time-of-flight (TOF), which is the time interval (several ms) between the time when pulse A is output from at least one piezoelectric element 11 and the time when pulse B is detected by the piezoelectric element 11.

[0117] On the other hand, although the present invention was described as generating an image of the skull of a target body using pulses A and B, it is not limited to this. That is, pulses A and B may be used in the image matching process with the MRI image (or CT image) described above in Figure 5.

[0118] Referring together to Figures 2 and 6b, based on a second electrical signal provided by the drive module 20, at least one piezoelectric element 11 performing a second function can output a pulse C of ultrasonic energy at a second resonant frequency (250 kHz) in the low-frequency range.

[0119] A pulse C of ultrasonic energy can be directed towards the cerebrovascular barrier of a desired brain tissue of the target object, and the cerebrovascular barrier can be opened by the pulse C of ultrasonic energy.

[0120] In this case, the acoustic cavitation generating material (microbubbles) can be located not only at the blood-brain barrier but also in the vicinity of the blood-brain barrier. Therefore, the output ultrasonic energy can be applied to (or reach) the acoustic cavitation generating material as well as the blood-brain barrier.

[0121] Acoustic cavitation generating material can experience resonance when subjected to ultrasonic energy pulses C, and can emit an acoustic signal D to the outside through the acoustic cavitation phenomenon.

[0122] The piezoelectric element 11, which performs the third function, can detect the acoustic signal D emitted from the acoustic cavitation generating material, and the judgment module 30 can analyze the acoustic signal D in real time.

[0123] The judgment module 30 can analyze the acoustic signal D to determine the behavior of the acoustic cavitation generating material by analyzing frequency components (125 kHz, 375 kHz, etc.) corresponding to n / 2 times the second resonant frequency (250 kHz, f2) (i.e., f2 × n / 2, n=1, 3, 5, ...) and frequency components (500 kHz, 750 kHz, ...) corresponding to n times the second resonant frequency (250 kHz, f2) (i.e., f2 × n, n=2, 3, 4, ...).

[0124] In other words, as described above in Figures 6a and 6b, the present invention outputs ultrasonic energy to the blood-brain barrier and the acoustic cavitation generating material, and at the same time analyzes the acoustic signal generated from the acoustic cavitation generating material to analyze the behavior of the acoustic cavitation generating material (e.g., the intensity of the behavior), thereby making it possible to determine whether or not the opening of the blood-brain barrier is being performed appropriately and safely.

[0125] Furthermore, the decision module 30 can perform Passive Acoustic Mapping (PAM) by analyzing multiple acoustic signals D detected by at least one piezoelectric element 11 (or more piezoelectric elements 11) that perform the fourth function, thereby simultaneously determining (or monitoring) the location and behavior of the acoustic cavitation generating material.

[0126] The process described above can be repeated for a pulse repetition frequency (PRF) of 1 Hz, but the present invention is not limited thereto. That is, the process described above can be repeated for various times set by the user.

[0127] As described above, the focused ultrasound processing system 1 for opening and monitoring the cerebral-vascular barrier of the present invention can not only open the cerebral-vascular barrier by utilizing low-frequency-based ultrasound energy with optimized skull penetration efficiency, but also acquire images of the skull by utilizing high-frequency-based ultrasound energy during the ultrasound energy output process, and adjust the position of the focused ultrasound processing device 10 or control the piezoelectric element 11 in real time through image matching, thereby irradiating a desired lesion with ultrasound energy.

[0128] In other words, the present invention not only allows for the acquisition of images of the skull by utilizing ultrasonic energy having a high-frequency resonant frequency and the adjustment of the position (or installation position and angle, etc.) of the focused ultrasonic processing device 10 to match the irradiation of ultrasonic energy, but also allows for the opening of the blood-brain barrier by utilizing ultrasonic energy having a low-frequency resonant frequency, thereby enabling the desired drug to be easily and safely delivered into the brain.

[0129] Furthermore, by analyzing acoustic signals generated by acoustic cavitation-generating materials located near the blood-brain barrier in real time, it is possible to estimate the degree of opening of the blood-brain barrier in real time. In addition, it is possible to determine the current location of the acoustic cavitation-generating materials and confirm or monitor whether the ultrasonic energy is being properly focused.

[0130] Figure 7 is a flowchart illustrating an ultrasonic control method for a focused ultrasound processing system for opening and monitoring the cerebral-vascular barrier according to one embodiment of the present invention.

[0131] In step S1, you can acquire MRI or CT images.

[0132] Specifically, the decision module 30 can upload MRI or CT images of the target body that have been pre-stored in the database.

[0133] In step S2, a skull image can be acquired using a high-frequency substrate.

[0134] Specifically, a focused ultrasonic device 10 may be pre-attached to the head of the target body. The drive module 20 can provide a first electrical signal to at least one piezoelectric element 11 that is pre-designated to perform a first function.

[0135] The ultrasonic device 10 can output a first ultrasonic energy having a first resonant frequency (approximately 3000 kHz) in the direction of the skull of the target body based on a first electrical signal.

[0136] The first ultrasonic energy is output from the piezoelectric element 11, reaches the surface of the skull of the target body, is reflected from the surface of the skull, and returns to the piezoelectric element 11.

[0137] At this time, the judgment module 30 can acquire an image of the skull by measuring the time of flow (TOF), which is the period between the time when the first ultrasonic energy is output from the piezoelectric element 11 and the time when the first ultrasonic energy reflected back from the surface of the skull is detected.

[0138] Video synchronization can be performed in step S3.

[0139] Specifically, the judgment module 30 can perform image matching by comparing and analyzing the MRI or CT image of the target body acquired in step S1 with the skull image acquired in step S2.

[0140] In step S4, it can be determined whether the video consistency error rate is less than or equal to x mm.

[0141] Specifically, the judgment module 30 can determine whether the image matching error rate between the MRI or CT image of the target body acquired in step S1 and the image of the skull acquired in step S2 is less than or equal to a preset x mm.

[0142] If the image matching error rate exceeds a preset x mm, the process returns to step S3, where the skull image acquired in step S2 is adjusted (e.g., rotated), and image matching with the MRI or CT image of the target body acquired in step S1 is re-executed. This process can be repeated until the image matching error rate is less than or equal to the preset x mm.

[0143] In step S5, the current position coordinates of the focused ultrasonic device and the current position coordinates of the focus point can be derived.

[0144] Specifically, if the image matching error rate is less than or equal to a preset x mm (i.e., the point where the error rate between images is smallest or when image matching is complete), the judgment module 30 can acquire the current three-dimensional coordinate values ​​(X, Y, Z) of the focused ultrasonic device 10 attached to the target object.

[0145] Furthermore, as described above in Figure 5, the judgment module 30 can acquire the coordinate values ​​of the focal point (Xf, Yf, Zf) of the ultrasonic energy output from the current position based on the acquired current three-dimensional coordinate values ​​(X, Y, Z) of the focused ultrasonic processing device 10 (i.e., by utilizing the prior sound field characteristic data).

[0146] As described above in Figure 5, the moving device can move the focusing ultrasonic device 10 by additionally utilizing sound field characteristic prior data, or by adjusting the position of at least one piezoelectric element 11, and obtain new three-dimensional coordinate values ​​(X1, Y1, Z1) of the adjusted focusing ultrasonic device 10 and new three-dimensional target focus point coordinate values ​​(Xf1, Yf1, Zf1) of the ultrasonic energy.

[0147] In step S6, ultrasound energy can be delivered to the brain lesion target.

[0148] In other words, from the current three-dimensional coordinate values ​​(X1, Y1, Z1) of the focused ultrasound processing device 10 acquired in step S5, at least one piezoelectric element 11 can output a second ultrasonic energy having a low-frequency second resonant frequency (approximately 250 kHz) toward the target object (e.g., a brain lesion target).

[0149] Specifically, the drive module 20 can provide a second electrical signal to the piezoelectric element 11, which is pre-configured to perform a second function. At this time, the focused ultrasonic processing device 10 can output a second ultrasonic energy having a second resonant frequency (approximately 250 kHz) to the blood-brain barrier and microbubbles located near the blood-brain barrier.

[0150] Step S7 allows the cerebrovascular barrier to be opened.

[0151] Specifically, the second ultrasonic energy output from at least one piezoelectric element 11 reaches the cerebrovascular barrier and the microbubbles located in its vicinity, thereby allowing the cerebrovascular barrier to be opened.

[0152] In step S8, the opening of the blood-brain barrier can be analyzed based on the acoustic signal.

[0153] Specifically, the piezoelectric element 11 configured to perform a third function can receive an acoustic signal generated by an acoustic cavitation generating material, which can be provided to the decision module 30.

[0154] The judgment module 30 can analyze the acoustic signal to determine the behavior of acoustic cavitation generating material by analyzing frequency components (125 kHz, 375 kHz, etc.) corresponding to n / 2 of the second resonant frequency (250 kHz, f2) (i.e., f2 × n / 2, n=1, 3, 5, ...) and frequency components (500 kHz, 750 kHz, ...) corresponding to f2 × n (n=2, 3, 4, ...).

[0155] Based on the behavior of the acoustic cavitation generating material, if the microbubbles are about to burst or otherwise exceed the opening of the blood-brain barrier, potentially leading to damage to surrounding tissue cells, the intensity of the ultrasound energy can be reduced.

[0156] Furthermore, multiple piezoelectric elements 11 configured to perform a fourth function can receive multiple acoustic signals generated by the acoustic cavitation generating material and provide them to the decision module 30. Based on the multiple acoustic signals, the decision module 30 can perform Passive Acoustic Mapping (PAM) and simultaneously determine the location and behavior of the acoustic cavitation generating material.

[0157] Through this, it is possible to monitor whether the ultrasonic energy is focused to the desired position based on the position determination of the acoustic cavitation generating material, and if it is not focused to the desired position, the position of the piezoelectric element can be adjusted as in step S6.

[0158] In step S9, it is possible to determine whether the error rate is less than or equal to ymm using video based on Passive Acoustic Mapping (PAM).

[0159] Specifically, the decision module 30 can acquire PAM video based on the Passive Acoustic Mapping performed in step S8. The decision module 30 can also determine whether the error rate of the PAM video is less than or equal to ymm.

[0160] If the error rate of the PAM image exceeds ymm, the position of the focal point of the ultrasound energy output from the current position of the focused ultrasound processing device 10 and the position of the brain lesion target will not match correctly. In this case, the process returns to step S6 to reset the focal point coordinates of the ultrasound energy output from the focused ultrasound processing device 10 and re-output the ultrasound energy.

[0161] Steps S6-S9 can be repeated until the PAM image error rate falls below ymm, allowing for real-time resetting of the ultrasound energy focus point during the process of opening the cerebral-vascular barrier using ultrasound energy. This improves the accuracy of opening the cerebral-vascular barrier.

[0162] While pre-stored sound field characteristic data can be used to reset the focal point of ultrasonic energy, the present invention is not limited to this.

[0163] In step S10, it is possible to determine whether or not the predetermined time has been met.

[0164] Specifically, if the error rate of the PAM image in step S9 is y mm or less, the focal point of the ultrasound energy output from the current position of the focused ultrasound processing device 10 and the position of the brain lesion target will correctly coincide, allowing the judgment module 30 to determine whether or not a preset time (e.g., treatment time) has been met. The preset time can be set in various ways by the user.

[0165] If the predetermined time has not been met, the process can return to step S7 and re-execute opening the blood-brain barrier using a low-frequency substrate. In other words, steps S7 to S10 may be repeated until the predetermined time has been met.

[0166] In step S11, the output of ultrasonic energy can be terminated.

[0167] Specifically, the output of ultrasound energy can be terminated once a predetermined time (for example, treatment time) has been met.

[0168] The drawings referenced and the detailed description of the invention provided herein are merely illustrative and used solely for the purpose of illustrating the invention, and not to limit the scope of the invention as defined in the claims. Therefore, those skilled in the art will understand that various modifications and equivalent other embodiments are possible. Thus, the true scope of technical protection of the invention should be determined by the technical concept of the appended claims.

[0169] The embodiments described above can be implemented by hardware components, software components, and / or combinations of hardware components and software components. For example, the apparatus, methods, and components described in the embodiments can be implemented using one or more general-purpose or special-purpose computers, as well as processors, controllers, ALUs (Arithmetic logic units), digital signal processors, microcomputers, FPGAs (Field programmable gate arrays), PLUs (Programmable logic units), microprocessors, or any other devices capable of executing and responding to instructions.

[0170] A processing unit can run an operating system and one or more software applications that run on that operating system. Furthermore, in response to the execution of software, the processing unit can access, store, manipulate, process, and generate data. While the processing unit has sometimes been described as being used in a single unit for ease of understanding, those skilled in the art will understand that a processing unit may include multiple processing elements and / or multiple types of processing elements.

[0171] For example, a processing unit can include multiple processors or one processor and one controller. Other processing configurations, such as a parallel processor, are also possible. Software can include a computer program, code, instructions, or one or more of these, and can configure the processing unit to perform a desired operation or direct the processing unit independently or collectively.

[0172] Software and / or data may be embodied in any kind of machine, component, physical device, virtual device, computer recording medium, or device in order to be interpreted by a processing device or to provide instructions or data to a processing device. Software may also be distributed across a networked computer system and stored or executed in a distributed manner. Software and data may be stored on one or more computer-readable recording media.

[0173] The methods described in the embodiments can be implemented in the form of program instructions executable through various computer means and recorded on a computer-readable medium. The computer-readable medium may include program instructions, data files, data structures, etc., individually or in combination. The program instructions recorded on the medium may be specifically designed and configured for the embodiments, or they may be well-known and available to those skilled in the computer software art.

[0174] Examples of computer-readable recording media include magnetic media such as hard disks, floppy disks, or magnetic tapes; optical media such as CD-ROMs and DVDs; and hardware devices specifically configured to store and execute program instructions, such as ROM, RAM, and flash memory. Examples of program instructions include not only machine code generated by a compiler, but also high-level language code that can be executed by a computer using an interpreter or the like. The hardware devices described above may be configured to operate as one or more software modules to perform the operations of the embodiment, and vice versa.

[0175] As described above, the embodiments have been explained by limited embodiments and drawings, but those skilled in the art will understand that various modifications and variations are possible from the above description. For example, the described technique may be performed in a different order than described, and / or the components of the described system, structure, apparatus, circuit, etc. may be combined or combined in a different manner than described, or replaced or substituted by other components or equivalents, and still achieve the desired results. Therefore, other embodiments, other examples, and equivalents to the claims described herein also fall within the scope of the claims described below.

Claims

1. A piezoelectric element comprising at least one single structure, A drive module that provides an electrical signal such that ultrasonic energy having one of a plurality of resonant frequencies or ultrasonic energy having at least two or more resonant frequencies is output by the at least one piezoelectric element, A focused ultrasound processing system for opening and monitoring the blood-brain barrier, including a cerebral-vascular barrier.

2. In the focused ultrasonic processing system according to claim 1, The at least one piezoelectric element is a focused ultrasound processing system for opening and monitoring the cerebral-vascular barrier, wherein the member interacting with the ultrasonic energy is composed of one or more materials.

3. In the focused ultrasonic processing system according to claim 1, A focused ultrasound processing system for opening and monitoring the cerebral-vascular barrier, wherein the at least one piezoelectric element outputs the ultrasonic energy to a target object or an acoustic cavitation generating substance administered to the target object.

4. In the focused ultrasonic processing system according to claim 3, A focused ultrasound processing system for opening and monitoring the blood-brain barrier, wherein the at least one piezoelectric element receives an acoustic cavitation signal reflected by the target object or generated by the acoustic cavitation phenomenon of the acoustic cavitation generating material.

5. In the focused ultrasonic processing system according to claim 4, The aforementioned plurality of resonant frequencies are, The first resonant frequency and A second resonant frequency, which is a frequency value lower than the first resonant frequency, A focused ultrasound processing system for opening and monitoring the blood-brain barrier, including a cerebral-vascular barrier.

6. In the focused ultrasonic processing system according to claim 5, The focused ultrasound processing system for opening and monitoring the cerebral-vascular barrier is, A focused ultrasound processing system for opening and monitoring the blood-brain barrier, further comprising a determination module for analyzing the acoustic cavitation signal to generate an image of the target object or to determine the location or behavior of the acoustic cavitation generating substance.

7. In the focused ultrasonic processing system according to claim 6, The aforementioned determination module is A focused ultrasound processing system for opening and monitoring the blood-brain barrier, comprising: analyzing the acoustic cavitation signal generated when a first ultrasonic energy having the first resonant frequency is reflected from the target object; and generating the image.

8. In the focused ultrasonic processing system according to claim 7, The aforementioned determination module is A focused ultrasound processing system for opening and monitoring the blood-brain barrier, which generates an image by measuring the Time Of Flight (TOF), which is the period between the time when the first ultrasonic energy is output by at least one piezoelectric element and the time when the acoustic cavitation signal is detected.

9. In the focused ultrasonic processing system according to claim 5, The at least one piezoelectric element is A focused ultrasound processing system for opening and monitoring the cerebral-vascular barrier, which outputs a second ultrasonic energy having the second resonant frequency to open the target object.

10. In the focused ultrasonic processing system according to claim 9, A focused ultrasonic processing system for opening and monitoring the blood-brain barrier, wherein the target object is the blood-brain barrier, and the acoustic cavitation generating substance is a microbubble located in the vicinity of the target object.

11. In the focused ultrasonic processing system according to claim 6, The aforementioned determination module is A focused ultrasound processing system for opening and monitoring the blood-brain barrier, which extracts frequency components corresponding to n / 2 of the second resonance frequency from the acoustic cavitation signal to determine the behavior of the acoustic cavitation generating material, where n is a natural number other than 2.

12. In the focused ultrasonic processing system according to claim 6, The aforementioned determination module is A focused ultrasound processing system for opening and monitoring the blood-brain barrier, comprising analyzing the acoustic cavitation signal generated by a second ultrasonic energy having the second resonant frequency to determine the location of the acoustic cavitation generating substance.

13. In the focused ultrasonic processing system according to claim 6, Each of the at least one piezoelectric element is A first function for outputting the aforementioned ultrasonic energy to generate an image of the target object, A second function for outputting the aforementioned ultrasonic energy to release the target object, A third function for analyzing the acoustic cavitation signal and determining the behavior of the acoustic cavitation generating material, A fourth function for analyzing the acoustic cavitation signal and simultaneously determining the location and behavior of the acoustic cavitation generating material, A focused ultrasound processing system for opening and monitoring the cerebrovascular barrier, performing at least two of the following functions.

14. An ultrasonic control method for a focused ultrasound processing system for opening and monitoring the cerebrovascular barrier, driven by at least one processor, The steps include providing an electrical signal to at least one processor such that ultrasonic energy having at least one resonant frequency among a plurality of resonant frequencies is output, The steps include: using at least one processor to receive the electrical signal and output the ultrasonic energy having the resonant frequency to the target object and the acoustic cavitation generating substance applied to the target object; An ultrasonic control method for a focused ultrasound processing system for opening and monitoring the blood-brain barrier, including.

15. A computer-readable recording medium on which a program for performing an ultrasonic control method for a focused ultrasound processing system for opening and monitoring the cerebrovascular barrier according to claim 14 is recorded.

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