6,6-condensed bicyclic amides and compositions for use as 15-prostaglandin dehydrogenase modulators
Novel amide-6,6-condensed bicyclic heteroaryl compounds inhibit 15-PGDH, addressing the need for effective modulators to treat 15-PGDH-mediated diseases by regulating prostaglandin levels.
JP2026517842APending Publication Date: 2026-06-02AMGEN INC
Patent Information
- Authority / Receiving Office
- JP · JP
- Patent Type
- Applications
- Current Assignee / Owner
- AMGEN INC
- Filing Date
- 2024-05-07
- Publication Date
- 2026-06-02
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Figure 2026517842000001_ABST
Abstract
This disclosure provides novel 15-hydroxy-prostaglandin dehydrogenase inhibitors, pharmaceutical compositions comprising such compounds, and methods for using such compounds and compositions in the treatment of 15-hydroxy-prostaglandin dehydrogenase-mediated diseases. Methods for producing such compounds and their intermediates are also provided. The compounds are of formula (I): Having the structure of TIFF2026517842000380.tif19170 or a pharmaceutically acceptable salt thereof, in the formula TIFF2026517842000381.tif19170 is either formula (i) or formula (ii). Furthermore, this disclosure provides intermediates useful for the synthesis of compounds of formula (I).
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