CNDP2 modulator and how to use it

Abstract

This disclosure features chemical entities (e.g., compounds or pharmaceutically acceptable salts of compounds, and / or hydrates, and / or cocrystals, and / or drug combinations, and / or stereoisomers (e.g., enantiomers and diastereomers)) that inhibit (e.g., antagonistize) carnosine dipeptidase 2 (CNDP2). These chemical entities are useful in treating conditions, diseases, or disorders (e.g., cancer) in which increased (e.g., excessive) CNDP2 activation contributes to the pathology and / or symptoms and / or progression of the condition, disease, or disorder in a subject (e.g., human). This disclosure also features compositions containing them, as well as methods for using and producing them.

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