Nasal warming for viral infection prevention

Abstract

The present invention describes a system and method for a device which may include a nasal assembly. The nasal assembly includes a first support member having a first surface configured to substantially conform to the left contour of the nose when the nasal assembly is fitted, a second support member having a second surface configured to follow the right contour of the nose when the nasal assembly is fitted, and a heat source electrically coupled to the first support member and the second support member, configured to adjust the surface temperatures of the first surface and the second surface and to heat the left and right contours of the nose to a predetermined temperature range.

Description

Technical Field

[0001] Cross - reference to Related Applications This application claims the benefit of priority of U.S. Patent Application No. 18 / 318,671, filed May 16, 2023 (issued as U.S. Patent No. 11,877,950), and the disclosure of this document is hereby incorporated by reference in its entirety into this specification. Incorporation by Reference

[0002] All publications and patent applications mentioned in this specification are hereby incorporated by reference in their entirety, as if each individual publication or patent application was specifically and individually indicated to be incorporated by reference in its entirety.

[0003] The present disclosure generally relates to the field of heating devices, and more specifically, to the field of heating devices having a nasal mucosa heating function.

Background Art

[0004] The term "nasal cavity" can refer to the inner part of the nose, including each of the left and right sides of the nose. The nasal cavity functions to condition the air entering the nasal vestibule and prepare it to be received by other regions of the airway. The nasal cavity can contain a number of extracellular vesicles (EVs) that function to provide inter - cellular communication within the tissues of the nasal cavity. EVs can transport components (e.g., DNA, RNA, proteins, and small molecules) from cell to cell.

Summary of the Invention

[0005] There is a need for novel and useful systems and methods for enhancing the ability of the nasal cavity to expel viral and / or bacterial particles.

[0006] In some embodiments, the technology described herein relates to a nasal assembly comprising: a first support member having a first surface configured to substantially conform to the left contour of the nose when the nasal assembly is fitted; a second support member having a second surface configured to follow the right contour of the nose when the nasal assembly is fitted; and a heat source electrically coupled to the first support member and the second support member, the heat source being configured to adjust the surface temperatures of the first surface and the second surface to heat the left contour and the right contour of the nose to a predetermined temperature range.

[0007] In some embodiments, the technology described herein relates to a nasal assembly in which the left contour of the nose is located within a first portion of the nasal cavity and the right contour of the nose is located within a second portion of the nasal cavity, and the first surface and the second surface are configured such that when the first surface and the second surface are heated, they heat the first portion of the nasal cavity and the second portion of the nasal cavity to a predetermined temperature range, the predetermined temperature range being approximately 37 degrees Celsius to approximately 39 degrees Celsius.

[0008] In some embodiments, the technology described herein relates to a nasal assembly comprising a first portion of the nasal cavity including a left nostril having a first tissue portion covered by a first mucous layer, and a second portion of the nasal cavity including a right nostril having a second tissue portion covered by a second mucous layer, wherein the first surface and the second surface are configured to heat the first tissue portion and the second tissue portion, respectively, when the first surface is positioned in contact with the left contour and the second surface is positioned in contact with the right contour.

[0009] In some embodiments, the technology described herein relates to a nasal assembly, the nasal assembly further comprising a sensor adapted to contact at least a portion of the nasal cavity of the nose, the sensor configured to monitor a portion of the nasal cavity, and a power supply mounted on a first or second support member, the power supply electrically coupled to a heat source and the sensor.

[0010] In some embodiments, the technology described herein relates to a nasal assembly in which a sensor is a temperature sensor, the temperature sensor is configured to monitor the temperature of a portion of the nasal cavity, and in response to detection that the surface temperature of the portion of the nasal cavity is below a predetermined temperature range, activate a heat source to perform a heating cycle, and in response to detection that the surface temperature of the portion of the nasal cavity is above the predetermined temperature, deactivate the heat source.

[0011] In some embodiments, the technology described herein relates to a nasal assembly in which a sensor is a temperature sensor, the temperature sensor is configured to monitor the temperature of the environment surrounding the nasal assembly and to transmit a signal to a heat source to selectively activate the heat source based on the temperature of the environment surrounding the nasal assembly.

[0012] In some embodiments, the technology described herein relates to a nasal assembly, the nasal assembly further includes an antenna circuit, which is configured to wirelessly communicate with at least one external computing device so that at least one external computing device can wirelessly operate the nasal assembly.

[0013] In some embodiments, the technology described herein relates to a nasal assembly in which a first support member is an intranasal insert configured to warm the nasal cavity of the nose, the intranasal insert comprising an elongated body, the elongated body having sufficient length to extend through the nasal vestibule into at least a portion of the nasal cavity when the elongated body is inserted into the nostrils of the nose, and the elongated body comprising an outer surface having a plurality of non-fixed baffles configured to increase resistance to airflow within the nostrils.

[0014] In some embodiments, the technology described herein relates to a nasal assembly in which a plurality of non-fixed baffles include flexible flaps, slits, notches, or perforations that allow air to flow from the inner surface of an elongated body to the outer surface of an elongated body. In some embodiments, the technology described herein relates to a nasal assembly in which an intranasal insert is a laminated continuous grid structure configured to generate pressure against a portion of the surface of the nasal cavity when inserted into the nostrils, thereby partially narrowing the nostrils.

[0015] In some embodiments, the technology described herein relates to a nasal assembly wherein the left and right contours of the nose are external anatomical regions of the nose, and the first and second surfaces are configured to heat one or more internal portions of the nose to a predetermined temperature range when the first and second surfaces are heated, the predetermined temperature range being approximately 41 to 43 degrees Celsius, and the one or more internal portions of the nose are located opposite the external anatomical regions of the nose at the respective positions of the left and right contours of the nose.

[0016] In some embodiments, the technology described herein relates to a nasal assembly in which the external anatomical region of the nose includes at least one surface of the nasal bridge, left lateral wall, right lateral wall, paranasal cartilage, or nasal septum cartilage, and one or more internal parts of the nose are heated to a predetermined temperature range by heating a first surface and a second surface, the one or more internal parts of the nose being opposite to the respective nasal bridge, left lateral wall, right lateral wall, paranasal cartilage, or nasal septum cartilage. In some embodiments, the technology described herein relates to a nasal assembly in which the predetermined temperature range is approximately 37 degrees Celsius to approximately 39 degrees Celsius.

[0017] In some embodiments, the technology described herein relates to a nasal assembly in which a first support member is connected to a second support member by a bridge member having a substantially C-shaped structure.

[0018] In some embodiments, the technology described herein relates to a nose assembly in which a bridge member includes a first end connected to a first support member and a second end connected to a second support member, the bridge member configured to cause the first support member to apply pressure to the left contour of the nose and the second support member to apply pressure to the right contour of the nose.

[0019] In some embodiments, the technology described herein relates to a nose assembly wherein, when pressure is applied to the left contour of the nose, the left wall of the nose moves inward toward the central axis of the nose, thereby narrowing the left nostril, and when pressure is applied to the right contour of the nose, the right wall of the nose moves inward toward the central axis of the nose, thereby narrowing the right nostril. In some embodiments, the technology described herein relates to a nose assembly wherein the nose assembly is configured to be detachably attached to the bridge portion of eyeglasses or to the lens of eyeglasses.

[0020] In some embodiments, the technology described herein relates to a wearable system for warming a nasal cavity, the system comprising: a processor; a sensor adapted to be positioned adjacent to a portion of the nose and configured to detect the temperature of the portion of the nose and to wirelessly output the detected temperature to the processor; and a heat source communicably coupled to the sensor and the processor, the heat source being positioned in contact with the contour of the nose, wherein the processor is configured to receive the detected temperature of the nose and to cause the heat source to change the temperature of the nasal cavity based on the detected temperature of the nose.

[0021] In some embodiments, the technology described herein relates to a system in which part of the nose is part of the nasal cavity, and a sensor is installed in a piece of jewelry configured to be placed in a nose piercing associated with the nose, so that when the jewelry is worn in the nose piercing, the sensor comes into contact with part of the nasal cavity, and the sensor is further configured to monitor the internal temperature of the nasal cavity and to wirelessly communicate with a processor and a heat source to trigger heating of the nasal cavity until a target temperature range is reached. In some embodiments, the technology described herein relates to a system in which the target temperature range is approximately 37 degrees Celsius to approximately 39 degrees Celsius.

[0022] In some embodiments, the technology described herein relates to a system in which the heat source is a piece of jewelry configured to be placed within a nose piercing associated with the nose, so that when the jewelry is fitted within the nose piercing, the heat source comes into contact with a portion of the nasal cavity associated with the nose, and a sensor is installed within a bridge member configured to be fitted over the nose, and the heat source is further configured to heat the inner surface of the nose in response to the sensor detecting that the temperature of the nose is outside a target temperature range.

[0023] In some embodiments, the technology described herein relates to a system in which the sensor is adapted to be fitted inside a portion of the nasal cavity. In some embodiments, the technology described herein relates to a system further comprising one or more antennas that wirelessly communicate with a mobile computing device and are configured to selectively activate a heat source based on the detected temperature of the environment surrounding the wearable system.

[0024] In some embodiments, the technique described herein is a method for reducing viral replication in the nasal mucosa, the method comprising: providing a device that contacts the contour of a user's nose, the device comprising a heating assembly and a temperature sensor, the device configured to at least partially restrict the airflow into the nose; monitoring the temperature of a portion of the nose with the temperature sensor; activating the heating assembly in response to the temperature sensor detecting that the temperature of a portion of the nose is below a predetermined temperature range to raise the temperature of the portion of the nose to within the predetermined temperature range; and maintaining the temperature of the portion of the nose within the predetermined temperature range until a signal is received to deactivate the heating assembly.

[0025] In some embodiments, the technology described herein is a method wherein the portion of the nose is the inferior turbinate and the predetermined temperature range is about 37 degrees Celsius to about 39 degrees Celsius. In some embodiments, the technology described herein is a method wherein the portion of the nose is the nasal vestibule and the predetermined temperature range is about 41 degrees Celsius to about 43 degrees Celsius. In some embodiments, the technology described herein is a method further comprising deactivating a heating assembly when the portion of the nose reaches a temperature within the predetermined temperature range.

[0026] In some embodiments, the technique described herein is a method comprising a device further comprising an antenna circuit configured to wirelessly communicate with at least one external computing device so that at least one external computing device can wirelessly operate the device, the method further comprising monitoring the ambient temperature of a portion of the device and transmitting a signal to a heating assembly to selectively activate the heating assembly based on the ambient temperature of a portion of the device.

[0027] In some aspects, the technology described herein relates to a method that includes at least partially constricting the airflow into the nose, which involves at least partially occluding the nostrils of the nose. In some aspects, the technology described herein relates to a method in which the device includes a convex central portion located centrally between a first end and a second end of the device, and the central portion is adapted to be formed to fit the contour of the nose.

[0028] Details of one or more embodiments are set forth in the accompanying drawings and the description below. Other features will be apparent from the specification and drawings, and from the claims.

[0029] The foregoing is a summary and, as such, necessarily somewhat detailed. The foregoing aspects of the technology, as well as other aspects, features, and advantages, will be described below in connection with various embodiments, with reference to the accompanying drawings.

Brief Description of the Drawings

[0030] [Figure 1] It is an example diagram of the anatomical structure of the human nose. [Figure 2A] It is a diagram showing an exemplary embodiment of a nasal assembly for warming a part of the nose. [Figure 2B] It is a diagram showing an exemplary embodiment of a nasal assembly for warming a part of the nose. [Figure 2C] It is a diagram showing an exemplary embodiment of a nasal assembly for warming a part of the nose. [Figure 2D] It is a diagram showing an exemplary embodiment of a nasal assembly for warming a part of the nose. [Figure 2E] It is a diagram showing an exemplary embodiment of a nasal assembly for warming a part of the nose. [Figure 3A] It is a diagram showing an exemplary embodiment of a nasal assembly that is part of glasses. [Figure 3B] It is a diagram showing an exemplary embodiment of a nasal assembly that is part of glasses. [Figure 3C]This figure shows an exemplary embodiment of a nose assembly, which is part of eyeglasses. [Figure 4] This figure shows another exemplary embodiment of a nose assembly, which is part of eyeglasses. [Figure 5A] This figure shows an exemplary embodiment of an internal nasal assembly. [Figure 5B] This figure shows an exemplary embodiment of an internal nasal assembly. [Figure 5C] This figure shows an exemplary embodiment of an internal nasal assembly. [Figure 5D] An exemplary embodiment of the internal nasal assembly is shown. [Figure 5E] This figure shows an exemplary embodiment of an internal nasal assembly. [Figure 6A] This figure shows an exemplary embodiment of a nasal assembly for heating and / or monitoring a portion of the nose. [Figure 6B] This figure shows an exemplary embodiment of a nasal assembly for heating and / or monitoring a portion of the nose. [Figure 7] This figure shows an exemplary embodiment of a nasal assembly for heating and / or monitoring a portion of the nose. [Figure 8] This figure shows an exemplary system for heating and monitoring a portion of the nose. [Figure 9] This figure illustrates an exemplary process for reducing viral replication or bacterial particle infection in the nasal mucosa.

[0031] The embodiments described herein are for illustrative purposes only and are not intended to limit the scope of this disclosure. Schematic diagrams are drawn to illustrate features and concepts and are not necessarily drawn to a specific scale. [Modes for carrying out the invention]

[0032] The above is a summary, and therefore the details are necessarily limited. Next, the aforementioned aspects of the Technology, as well as other aspects, features, and advantages, will be described in relation to various embodiments. The inclusion of the following embodiments is not intended to limit the disclosure to these embodiments, but rather to enable any person skilled in the art to manufacture and use the subject matter described in the claims. Other embodiments may be available and may be modified without departing from the spirit or scope of the subject matter presented herein. The aspects of the disclosure may be arranged, combined, modified, and designed in various different constructions as described and illustrated herein, all of which are expressly intended and constitute part of the disclosure.

[0033] Recent history has shown that many conventional strategies (e.g., products that at least reduce the virus, drugs that reduce the virus, and masks that don't fit the body or are of poor quality) have proven ineffective in reducing infection and / or viral replication in human populations. For example, viruses (e.g., the common cold or SARS-CoV-2) were unaffected by conventional antiviral strategies. Generally, the common cold or SARS-CoV-2 may begin to replicate more rapidly at temperatures below approximately 37 degrees Celsius because these viral cells replicate more efficiently at lower temperatures. Conventional antiviral strategies cannot exploit the weakness of viruses that cannot replicate (or replicate more slowly) at temperatures above approximately 37 degrees Celsius. The systems and methods described herein can, in general, solve this technical problem related to viral replication in the nasal mucosa and nasal cavity. For example, the systems and methods described herein can reduce the risk of viral infection and / or further viral replication by increasing the temperature of the nasal cavity and / or nasal mucosa.

[0034] This is because a decrease in temperature inside the nose can significantly reduce the body's ability to defend against viral infection (through a mechanism that reduces extracellular vesicle (EV) production). The systems and methods described herein provide a way to warm the nasal cavity, maintain a specific temperature in the nasal cavity, and / or increase EV production within the nasal cavity by providing a nasal assembly that generates heat in or over a portion of the nose.

[0035] The systems and methods described herein have the advantage of providing a less conspicuous approach compared to face masks and other options. The direct heating and / or compression of a portion of the nose provided by the systems and methods described herein enables a more efficient and effective method of heating the inside of the nose than conventional systems and / or pharmaceuticals.

[0036] In particular, this specification discloses systems and methods for heating all or part of the nasal cavity within a user's nose. For example, internal and external wearable devices for heating the nasal cavity are described in detail throughout this disclosure. These internal devices, external devices, or combinations of internal / external devices may function alone or in combination to reduce the replication of viral (and / or bacterial) cells in the nasal cavity. The devices may reduce the replication of viral (and / or bacterial) cells in the nasal cavity by maximizing heat transfer to the nasal cavity. For example, the devices, systems, and methods described herein function to reduce the likelihood of viral particles (and / or bacterial particles) multiplying in the nasal mucosa within the nasal cavity by heating (e.g., warming, raising the temperature, etc.) the nasal cavity.

[0037] By reducing the likelihood of viral cells replicating in the nasal mucosa, it may be possible to reduce or prevent the virus from infecting cells in the nasal mucosa and / or nasal cavity, thus providing the benefit of reducing or preventing viral infection in the user's nose and body. In addition, the devices described herein may reduce the likelihood of viral particle replication without the use of a mask (e.g., one that covers the nose / mouth). In some embodiments, the devices described herein may be incorporated into a wearable object for convenience when wearing the device. Wearable objects may include, but are not limited to, eyeglasses, jewelry, nose plugs, nose clips, lens attachments, and any combination thereof.

[0038] Figure 1 shows an example diagram of the anatomical structure 100 of the human nose. The anatomical structure 100 includes the nose 102, the nasal cavity 104, and part of the sinuses and adenoids. The nasal vestibule 106 is shown as the entrance to the nose 102. The nasal vestibule 106 can receive air and particles that can be sent to the nasal cavity 104 through the nasal mucosa 108. The nasal cavity 104 may contain any number of nasal cells 110. Nasal cells may release (e.g., generate and disperse) extracellular vesicle (EV) particles 114 to protect the cells 110 from viral infection.

[0039] Extracellular vesicle (EV) particles 114 may contain numerous proteins (not shown) typically found on the surface of nasal cells 110. Proteins on the EV particles 114 may function to attract viral particles 112 to the EV particles 114, preventing the viral particles 112 from infecting cells 110, for example. If the nasal cavity 104 can be maintained at a predetermined temperature (i.e., above normal human body temperature of approximately 36-37 degrees Celsius) by releasing EV particles 114 to attach to and thus neutralize the viral particles 112, the nasal cavity 104 may be able to prevent viral infection. However, if the temperature of the nasal cavity 104 drops below approximately 36 degrees Celsius, the generation and release of EV particles 114 may not function efficiently because fewer EV particles 114 are produced and / or released at temperatures lower than normal human body temperature. This may increase the likelihood of viral particles 112 or bacterial particles infecting nasal cells 110.

[0040] Generally, the nasal cavity 104 can filter and humidify air as it flows into the nose 102. Filtration may be performed by cilia (not shown) and / or cilia (not shown) in the vestibule 106 by accumulating particulate matter. For example, the nasal mucosa 108 of the nasal cavity 104 includes tissue layers covered by layers of mucus (not shown), cilia (not shown), and cilia (not shown), each layer positioned along the surface of the nasal cavity 104. The mucus can cause particles to adhere to the nasal mucosa 108 and / or cilia and / or cilia, some or all of which can collect or remove (e.g., capture) particles from inhaled air. While the nasal cavity 104 and its associated anatomical structures can provide a partial filtering effect by purifying and cleaning the air taken into the body, the nasal cavity 104 alone is not adequately configured to provide a robust defense against bacterial and viral invaders.

[0041] For example, as the nasal cavity 104 warms and filters inhaled air, the nasal mucosa 108 (and / or the nasal cavity itself) can cool to temperatures below normal human body temperature (i.e., approximately 37 degrees Celsius). Studies have demonstrated that if airflow into the nasal cavity is not obstructed during periods of low external temperatures, the internal nasal temperature can drop to a considerable extent. For example, a study by Huang et al., ["Cold exposure impairs extracellular vesicle swarm-mediated nasal antiviral immunity," February 2023] p. 521, shows that "after the ambient temperature dropped from 23.3°C to 4.4°C, intranasal temperatures at the anterior and middle / inferior turbinate levels decreased by up to 6.4°C (P<.001) and 4.7°C (P<.001), respectively." When the temperature of the nasal mucosa 108 and / or nasal cavity 104 drops below such temperatures, the nasal cavity 104 may become more susceptible to certain viruses and / or bacteria. For example, viruses (e.g., the common cold or SARS-CoV-2) may begin to replicate more rapidly at temperatures below approximately 37 degrees Celsius. This is because these viral cells replicate more efficiently at lower temperatures, and EV particles also decrease statistically significantly by a relatively slight decrease in the internal nasal temperature (minimum 5°C) [ibid., p. 513, section 3]. Conversely, when the temperature of the nasal mucosa 108 (or nasal cavity 104) rises and / or is maintained above approximately 37 degrees Celsius, viral replication becomes less efficient, and EV particles 114 are activated, preventing infection / replication of viral particles within nasal cells 110.

[0042] Therefore, the devices described herein may prevent or reduce the possibility of viral particle replication within nasal cells 110 by raising or maintaining the temperature within the nasal cavity 104. For example, the devices described herein may include a heating source for raising or maintaining the temperature of the nasal cavity 104 and / or the environment surrounding the nasal cavity 104. The heating source may heat a portion of the nose 102 to maintain a temperature of approximately 37°C to approximately 39°C for at least a portion of the vestibule 106 and / or nasal cavity 104. The devices described herein may be configured to apply warmth from the outside or inside to reduce viral replication in the nasal mucosa of the user's nose. For example, the devices described herein may apply heat to the outer portion of the nose 102 and / or the inner portion of the nose 102. Such a device may trigger a heating cycle that raises the temperature within the vestibule 106 and / or nasal cavity 104, causing the generation of EV particles 114 to stop or reduce viral replication in the nasal cavity 104, nasal mucosa 108, and / or surrounding tissues. Systems and devices

[0043] Figures 2A–2E show exemplary embodiments of a nasal assembly for heating a portion of the nose 102. The embodiments in Figures 2A–2E may be configured to be fitted externally to the nasal cavity 104. For example, each embodiment described in Figures 2A–2E may be positioned on or near one or more external contours of the nose 102. As used herein, the term “external nasal contours” may include all or part of the nasal bridge, nasal ridge, nasal tip, nasal alae, right nasal wall, left nasal wall, paranasal cartilage, or nasal septal cartilage. Although the embodiments in Figures 2A–2E are described as being fitted externally to the nasal cavity 104, these embodiments may function in conjunction with other devices inside the nasal cavity 104 and / or computing devices outside the nasal cavity 104. In some embodiments, the embodiments in Figures 2A–2E may be adapted to function as devices inside the nasal cavity 104.

[0044] Figure 2A shows a perspective view of an exemplary nasal assembly 200A for warming at least a portion of the nasal cavity 104. The nasal assembly 200A may be a nasal clip or nasal ornament that can be removably coupled to be attached to the user's nose 102. The nasal assembly 200A includes a first support member 202 and a second support member 204. In some embodiments, the first support member 202 is coupled to the second support member 204 by a bridge member 206. The bridge member 206 may be a convex component located in the central or intermediate portion of the nasal assembly 200A. The central portion is located substantially in the middle between the first end 202a and the second end portion 204a of the device. The central portion may be adapted to fit at least a portion of the contour of the nose 102. For example, the central portion may be the entire bridge member 206 that can fit above or on the nasal bridge. A portion of the bridge member 206 may be in contact with the nose, while the other portion of the bridge member 206 may be positioned to extend over the skin of the nasal bridge.

[0045] In some embodiments, the first support member 202 and the second support member 204 are removablely attached to the user's nose 102 without a bridge member 206. For example, the support members 202, 204 may be removablely attached to the nose 102 by bonding them via an adhesive, sebum, tape, film, or other mechanical adhesive material that can be removed without damaging the skin surface of the nose 102. In some embodiments, the support members 202, 204 may be adapted to clamp a portion of the nose by clipping to the nose via a force induced by the bridge member 206. By clamping, pressure may be applied to the left contour of the nose (e.g., the left contour 248 in Figure 2D), which may cause the left wall (e.g., the inside of the nose) to move inward toward the central axis (C) of the nose, thereby narrowing the left nostril (e.g., the nostril 254 in Figure 2D). Furthermore, by clamping, pressure may be applied simultaneously to the right contour of the nose (for example, the right contour 252 in Figure 2D), which may cause the right wall (for example, the inside of the nose) to move inward toward the central axis (C) of the nose, thereby narrowing the right nostril (nostril 256 in Figure 2D). For example, the bridge member 206 may contain or be formed from a shape memory material so that the bridge member 206 can be stretched and fitted to the nose, and then applied to the nose by returning to its unstretched state.

[0046] The first support member 202 may include a first surface 208 configured to substantially conform to the left contour of the nose 102 (e.g., the left contour 248 in Figure 2D) when the nose assembly 200A is fitted by the user. Similarly, the second support member 204 may include a second surface 210 configured to follow the right contour of the nose 102 (e.g., the right contour 252 in Figure 2D) when the nose assembly 200A is fitted by the user. Generally, as illustrated in Figure 2D, the left and right contours of the nose are external anatomical regions of the nose 102. In some embodiments, the left and right contours of the nose may be internal contours within the nasal cavity or nose, as shown in Figures 2D and 5E.

[0047] As illustrated, the support members 202 and 204 are substantially elliptical in shape. The elliptical support members 202 and 204 can be positioned along the contour of the nose to cover a portion of the surface area of ​​the nose. Although the support members 202 and 204 are elliptical in the illustration, those skilled in the art can consider replacing them with different polygonal shapes. The size of the portion of the surface area can vary as described throughout this disclosure. In addition, the support members 202 and 204 can cover different portions of the surface area of ​​the nose depending on how the support members 202 and 204 are positioned on the contour of the nose. For example, the user can adjust the assembly 200A to comfort by positioning it laterally and / or laterally along the contour of the nose. In some embodiments, the user can adjust the assembly 200A to heat or cool a specific portion of the nose to a specific temperature by positioning it laterally and / or laterally along the contour of the nose. In some embodiments, heating or cooling a specific portion of the nose may be done to reduce viral replication in the nasal mucosa of the user's nose.

[0048] The nasal assembly 200A may further include a heat source (e.g., heat source 802 in Figure 8) electrically coupled to the first support member 202 and / or the second support member 204. Although the nasal assembly 200A is described as heating both the left and right sides of the nose, as will be apparent to those skilled in the art, the nasal assembly 200A may also heat the left side and not the right side, or heat the right side and not the left side. The heat source may be a wire, a coil, or other heating element placed within the support members 202, 204. The heat source may be electrically coupled to the electronics and power supply of the nasal assembly 200A to heat or cool the surface of the nose. For example, a heat source (as shown in Figure 8) may be powered and wired to regulate the surface temperature of a first surface 208 and / or a second surface 210 (of assembly 200A), heating the left contour of the nose 102 (e.g., the left contour 248 in Figure 2D) and the right contour of the nose 102 (e.g., the right contour 252 in Figure 2D), and further heating one or more internal portions of the nose 102 to a predetermined temperature or temperature range. One or more internal regions of the nose may be located opposite the external anatomical region of the nose being heated, and these could be the locations of the left contour 248 and the right contour 252, respectively. For example, the external anatomical region of the nose may include at least one surface of the nasal bridge, left lateral nasal wall, right lateral nasal wall, paranasal cartilage, or nasal septal cartilage, as shown in Figure 1. Generally, heating the first surface 208 and / or the second surface 210 will heat one or more internal portions of the nose to a predetermined temperature range. One or more internal parts of the nose 102 may be located opposite to their respective external anatomical regions, for example, the bridge of the nose, the left lateral wall of the nose, the right lateral wall of the nose, the paranasal cartilage, or the nasal septum cartilage.

[0049] The temperature of the surfaces 208, 210 of the respective support members 202, 204 may be adjusted until a predetermined temperature range is achieved. The predetermined temperature range may be approximately 39°C to 44°C, approximately 39°C to 41°C, approximately 40°C to 43°C, or approximately 41°C to 43°C. In some embodiments, the predetermined temperature range may be selected to ensure that the internal parts of the nose reach a specific temperature. For example, a predetermined temperature range for heating the external surface of the nose may be selected to ensure that the inferior turbinates of the nasal cavity of the user wearing the nasal assembly 200A reach a temperature range of, for example, approximately 37°C to 39°C. In another example, a predetermined temperature range for heating the external surface of the nose may be selected to ensure that the nasal vestibule reaches a temperature range of approximately 41°C to 43°C.

[0050] In some embodiments, the nasal assembly 200A includes an antenna circuit configured to wirelessly communicate with at least one external computing device, as detailed in Figure 8, so that the computing device can wirelessly operate the nasal assembly 200A. In addition, the nasal assembly 200A may include one or more sensors, a power supply, and / or a processor, as detailed in Figure 8. For example, the nasal assembly 200A may include one or more sensors adapted to be positioned adjacent to a portion of the nose 102. One or more sensors may detect the temperature of a portion of the nose 102 and wirelessly output the detected temperature to a processor.

[0051] Figure 2B shows a perspective view of another exemplary nasal assembly 200B for warming at least a portion of the nasal cavity 104. The nasal assembly 200B may be a nasal clip or nasal ornament that can be removably coupled to be worn on the user's nose 102. The nasal assembly 200A includes a first support member 220 and a second support member 222. In some embodiments, the first support member 220 is coupled to the second support member 222 by a bridge member 224. The bridge member 224 may be a convex component positioned in the central or intermediate portion of the nasal assembly 200B. The central portion may be adapted to fit at least a portion of the contour of the nose 102. For example, the central portion may be the entire bridge member 224 that can fit above or on the bridge of the nose. Part of the bridge member 224 may be in contact with the nose, while the other part of the bridge member 224 may be positioned to extend over the skin of the bridge of the nose.

[0052] In some embodiments, the bridge member 224 may have a substantially C-shaped structure. In some embodiments, the bridge member 224 may have a substantially flexible structure. In some embodiments, the bridge member may also provide heating to one or more portions of the nose 102.

[0053] In some embodiments, the first support member 220 and the second support member 222 are removablely attached to the user's nose 102 without a bridge member 224. For example, the support members 220, 222 may be removablely attached to the nose 102 by bonding them via an adhesive, sebum, tape, film, or other mechanical adhesive material that can be removed without damaging the skin surface of the nose 102. In some embodiments, the support members 220, 222 may be adapted to clamp a portion of the nose by clipping it to the nose via a force induced by the bridge member 224.

[0054] The first support member 220 includes a first surface 226 configured to substantially conform to the left contour of the nose 102 (e.g., the left contour 248 in Figure 2D) when the nose assembly 200B is fitted by the user. Similarly, the second support member 222 includes a second surface 228 configured to follow the right contour of the nose 102 (e.g., the right contour 252 in Figure 2D) when the nose assembly 200B is fitted by the user.

[0055] The support members 220, 222 can be substantially circular in shape. Circular support members 220, 222 can be positioned along the contour of the nose to cover a portion of the surface area of ​​the nose. Although the support members 220, 222 are circular in the illustration, those skilled in the art can consider replacing them with different polygonal shapes. The size of the portion of the surface area can vary as described throughout this disclosure. In addition, the support members 220, 222 can cover different portions of the surface area of ​​the nose depending on how the support members 220, 222 are positioned on the contour of the nose. For example, the user can adjust the assembly 200B to comfort by positioning it laterally and / or laterally along the contour of the nose. In some embodiments, the user can adjust the assembly 200B to heat or cool a specific portion of the nose to a specific temperature by positioning it laterally and / or laterally along the contour of the nose.

[0056] Similar to the nasal assembly 200A, the nasal assembly 200B includes a heat source (e.g., heat source 802 in Figure 8) that can heat or cool the surface of the nose, as described in detail herein. In addition, the nasal assembly 200B may include one or more sensors, a power supply, and / or a processor, as described in detail in Figure 8.

[0057] Figure 2C shows a perspective view of yet another exemplary nasal assembly 200C for warming at least a portion of the nasal cavity 104. The nasal assembly 200C may be a nasal clip or nasal ornament that can be removably coupled to be worn on the user's nose 102. The nasal assembly 200C includes a first support member 230 and a second support member 232. In some embodiments, the first support member 230 is coupled to the second support member 232 by a bridge member 234, similar to the bridge member 224 described above.

[0058] The first support member 230 includes a first surface 236 configured to substantially follow (and / or conform to and / or contact) the left contour 248 of the nose 102 when the nose assembly 200C is fitted by the user. Similarly, the second support member 232 includes a second surface 238 configured to substantially follow (and / or conform to and / or contact) the right contour 252 of the nose 102 when the nose assembly 200B is fitted by the user.

[0059] As illustrated, the support members 230, 232 can be substantially square in shape. The square support members 230, 232 can be positioned along the contour of the nose to cover a portion of the surface area of ​​the nose. Although the support members 230, 232 are square in the illustration, those skilled in the art can consider replacing them with different polygonal shapes. The size of the portion of the surface area can vary as described throughout this disclosure. In addition, the support members 230, 232 can cover different portions of the surface area of ​​the nose depending on how the support members 230, 232 are positioned on the contour of the nose. For example, the user can adjust the assembly 200C to comfort by positioning it laterally and / or laterally along the contour of the nose. In some embodiments, the user can adjust the assembly 200C to heat or cool a specific portion of the nose to a specific temperature by positioning it laterally and / or laterally along the contour of the nose.

[0060] Similar to nasal assemblies 200A and 200B, nasal assembly 200C includes a heat source (e.g., heat source 802 in Figure 8) that can heat or cool the surface of the nose, as described in detail herein. In addition, nasal assembly 200C may include one or more sensors, a power supply, and / or a processor, as described in detail in Figure 8. Generally, nasal assembly 200C may function similarly to nasal assemblies 200A and 200B and perform the processes described herein.

[0061] Figure 2D shows a side view of the nose assembly 200A of Figure 2A, positioned on the user's nose 102. The nose assembly 200A may be a nose clip or nose ornament that can be removably coupled to be attached to the user's nose 102. The nose assembly 200A includes a first support member 202 and a second support member 204. In some embodiments, the first support member 202 is coupled to the second support member 204 by a bridge member 206, as described above.

[0062] The first support member 202 includes a first surface 208 configured to substantially conform to the left contour 248 of the nose 102 when the nose assembly 200A is fitted by the user. Similarly, the second support member 204 includes a second surface 210 configured to follow the right contour 252 of the nose 102 when the nose assembly 200A is fitted by the user.

[0063] In some embodiments, the nasal assembly 200A may be positioned inside the nose. For example, instead of positioning the assembly 200A on the external contours 248, 252, the support members 202 may be positioned inside the nostril 254 and the support members 204 inside the nostril 256. The bridge member 206 may include or consist of a shape memory alloy (e.g., Nitinol®) or one or more combinations of zinc, copper, iron, or gold. The bridge member 206 may function to press the support members 202, 204 against the inner surfaces inside each nostril 254, 256.

[0064] Figure 2E shows a perspective view of the nose assembly 200C of Figure 2C on the user's nose 102. Here, the bridge member 234 may be under tension and can apply pressure to the nose 102 through the support members 230, 232. For example, when the bridge member 234 is under tension, it may compress the portion of the nose in contact with the support members 230, 232, thereby applying pressure to the left contour of the nose (e.g., the left contour 248 in Figure 2D), as a result, the left wall (e.g., the interior of the nose) may move inward toward the central axis (C) of the nose, narrowing the left nostril (e.g., the nostril 254 in Figure 2D). In addition, the compression may substantially simultaneously apply pressure to the right contour of the nose (e.g., the right contour 252 in Figure 2D), thereby applying pressure to the right wall (e.g., the interior of the nose) may move inward toward the central axis (C) of the nose, narrowing the right nostril (nostril 256 in Figure 2D).

[0065] The nasal assembly 200C may further include a heat source (e.g., heat source 802 in Figure 8) electrically coupled to the first support member 230 and the second support member 232. The heat source may be a wire, a coil, or another heating element placed within the bridge member 234. The heat source may be electrically coupled to the electronics and power supply of the nasal assembly 200C to heat or cool the surface of the nose. For example, the heat source may be powered and wired (as shown in Figure 8) to regulate the surface temperature of the portion of the nose in contact with the support members 230 and 232.

[0066] During operation, the nasal assembly 200C may begin to heat (or receive a command to heat) a portion of the nose 102 that is in contact with the support members 230, 232. Heating a portion of the nose 102 may further heat one or more internal portions of the nose 102 located within the nose and opposite the external anatomical region of the nose. For example, the external anatomical region of the nose may include, as shown in Figure 1, at least one surface of the nasal bridge, left lateral nasal wall, right lateral nasal wall, paranasal cartilage, or nasal septal cartilage. The assembly 200C may heat a portion of the nose 102 until it reaches a predetermined external nasal temperature or a predetermined internal nasal temperature, as described in detail herein.

[0067] In some embodiments, the bridge member 234 may include or be coupled to an antenna circuit 808 (Figure 8) configured to wirelessly communicate with at least one external computing device 801 (Figure 8), thereby allowing the computing device 801 to wirelessly operate the nasal assembly 200C, as detailed in Figure 8. Such a circuit may enable wireless monitoring, using a sensor 804 to monitor and / or change the temperature of the nasal assembly 200C, the internal temperature of the nose, the external temperature of the nose, and / or the ambient temperature of the area surrounding the nasal assembly.

[0068] Figures 3A–3C show exemplary embodiments of a nasal assembly 302, which is part of eyeglasses. Figure 3A shows eyeglasses 300 including the nasal assembly 302. Similar to the nasal assemblies described in Figures 2A–2E, the nasal assembly 302 may function to heat a portion of the nose to reduce viral replication and / or improve the efficiency of EV function in the nasal mucosa.

[0069] The eyeglasses 300 may represent one or more of the following: reading glasses, augmented reality (AR) glasses, virtual reality (VR) glasses, head-mounted displays (HMDs), or other head-based devices. The eyeglasses 300 includes lenses 304, 306 that are at least partially enclosed by a frame 308 (e.g., rims). The frame 308 is coupled to temples 310, 312 (e.g., arms) and nose pads 314, 316. The frame 308 includes a bridge 318. In some embodiments, if the frame 308 does not substantially enclose the lenses 304, 306 (e.g., wire-rimmed eyeglasses), the bridge 318 is coupled to a first rim (not shown) and a second rim (not shown). The eyeglasses 300 may include hinges, screws (or other fasteners) for coupling the frame 308 to the temples 310, 312, and / or coupling the nose pads 314, 316 to the bridge 318 and / or the frame 308.

[0070] The nasal assembly 302 may include a first support member 320 and a second support member 322. The first support member 320 is coupled to the distal end of a connecting member 324. The proximal end of the connecting member 324 is coupled to the frame 308 (or lens 304). The support member 320 includes a surface 326 that can substantially conform to the left contour of the nose 102 when the nasal assembly 302 is fitted by the user.

[0071] The second support member 322 is coupled to the distal end of the connecting member 328. The proximal end of the connecting member 328 is coupled to the frame 308 (or lens 306). The support member 322 includes a surface 330 configured to substantially conform to the left contour of the nose 102 when the nose assembly 302 is fitted by the user.

[0072] The nasal assembly 302 also includes a heat source (e.g., heat source 802 in Figure 8) electrically coupled to the first support member 320 and the second support member 322. The heat source 802 may be configured to heat the left and right contours of the nose by adjusting the surface temperatures of surface 326 and surface 330. Adjustment may include changing the temperatures of surfaces 326 and 330 to change the temperature of the nasal skin (and therefore the temperature inside the nose), bringing the nasal skin (e.g., nasal vestibule, nasal bridge, nasal septal cartilage, nasal lateral wall, etc.) to a predetermined temperature range (e.g., about 41°C to about 43°C) and / or bringing the internal parts of the nose (e.g., nasal cavity, nasal mucosa, or inferior turbinate, etc.) to a predetermined temperature range (e.g., about 37°C to about 39°C).

[0073] In some embodiments, a support member 320 coupled to a connecting member 324 may be an extension of the spectacle lens 304. Similarly, a support member 322 coupled to a connecting member 328 may be an extension of the spectacle lens 306. For example, the proximal ends of each connecting member 324, 328 may be coupled to the respective portions of the lenses 304, 306 and extend over the user's nose. In some embodiments, the connecting members 324, 328 may function to compress the upper part of the nose to increase restricted airflow. Restricted airflow may function to maintain a specific temperature of the nose and ensure that the assembly 302 is efficient in heating and / or maintaining the temperature of the nose.

[0074] In some embodiments, the nose assembly 302 also includes a battery charger 332. The battery charger 332 may be electrically coupled to one or more rechargeable batteries capable of generating a substantially continuous heating potential for the assembly 302. As illustrated, the battery charger 332 is located on a temple 312 to which a wall mount can be attached. In such examples, the battery charger 332 may be coupled to a heat source 802 and / or any coupled memory, processor, sensor, etc., wired within the frame 308, connecting member 328, connecting member 324, bridge 318, and / or temple 312.

[0075] Figure 3B shows an exemplary nose assembly 350 on a user's nose 102. In this example, the nose assembly 350 includes support members 320, 322 on the eyeglasses 300. The assembly 350 further includes compression bridges 352a, 352b. The compression bridges 352a, 352b may function to compress the upper part of the nose on both the left and right sides, increasing restricted airflow. Restricted airflow may function to maintain a specific temperature of the nose, ensuring that the assembly 350 is efficient in heating and maintaining the temperature of the nose.

[0076] Assembly 350 may also include a sensor 354 mounted on the temple 312. Sensor 354 may be an environmental sensor for detecting the temperature of the environment surrounding assembly 350 (e.g., ambient temperature). Assembly 350 may operate based on the measurements obtained by sensor 354. In some embodiments, sensor 354 may represent sensor 804. In some embodiments, sensor 354 may be added to assembly 350 in addition to sensor 804. In some embodiments, sensor 354 may be used instead of sensor 804 in assembly 350. As those skilled in the art will see, it may be considered to include further sensors on assembly 350.

[0077] Figure 3C shows an exemplary assembly 350 that can be attached to eyeglasses / lenses and used in place of nose pads on eyeglasses. Applying heat along the left and right sides of the bridge of the nose 370 of the nose 102 can warm the bridge and midline of the nose and warm the nasal cavity and / or nasal mucosa. In some embodiments, the assembly 350 may also compress a portion of the bridge of the nose to narrow the air passage in the nose, thereby further increasing the temperature of the nasal cavity.

[0078] In some embodiments, the exemplary assembly 350 may be removably applied to the nose, for example, via adhesive. Support members 320, 322 may be applied along the nose 102, on one or more sides of the nose. Since the assembly 350 can be fitted without further supports and / or components, any number of support members 320, 322 may be applied to the nose to increase heating along the nose and / or to counteract extremely cold environments outside the assembly 350.

[0079] Figure 4 shows another exemplary embodiment of the nasal assembly 350. The nasal assembly 350 includes support members 320, 322, compression bridges 352a, 352b, and an environmental sensor 354, as shown in Figure 3B. In this example, the compression bridges 352a, 352b may function to restrict airflow by compressing the upper part of the nose on both the left and right sides. The restricted airflow may allow the nose to maintain a specific temperature, ensuring that the assembly 350 is efficient in heating and / or maintaining the temperature of the nose.

[0080] In addition, the compression bridges 352a and 352b can also further heat the nasal bridge. Thus, the support members 320 and 322 and the bridges 352a and 352 can each heat a portion of the nose. Because additional heating components are provided within the assembly 350, each component (e.g., members 320 and 322, bridges 352a and 352b) can be heated simultaneously to reduce the elapsed heating time to reach the predetermined temperature range described herein. In some embodiments, each component (e.g., members 320 and 322, bridges 352a and 352b) can be heated sequentially to reduce the battery usage and / or energy consumption of the assembly 350. Such a heating sequence can be determined by artificial intelligence algorithms and / or machine learning models to optimize heating effect and battery life. Providing heating and compression by the nasal assembly 350 can increase the internal temperature of the nose and function to synergistically heat the inside of the nose through heating based on nasal congestion and external heating.

[0081] Figures 5A–5E show exemplary embodiments of internal nasal assemblies. The embodiments in Figures 5A–5E may be configured to apply warmth to the inner portion of the nose 102, triggering a heating cycle to raise the temperature inside the nasal cavity 104 and / or raise the temperature inside one or more layers of the nasal mucosa (e.g., without limitation, the epithelium, basement membrane, and lamina propria mucosa, and the cells, particles, and / or vesicles within them). As the embodiments in Figures 5A–5E heat (or maintain) one or more layers of the nasal mucosa to a predetermined temperature, extracellular vesicles (EVs) may increase in the nose, thereby reducing the proliferation of viral cells in the nasal cavity. When the assemblies described herein are placed inside the nostrils, air may be received through the hollow portions defined by each assembly.

[0082] In some embodiments, the nasal assemblies shown in Figures 5A–5E may be flexible, bendable, compressible, or otherwise easily bendable to fit the nostrils. In some embodiments, two nasal assemblies of a particular embodiment in Figures 5A–5E may actually be used by inserting the first nasal assembly into the first nostril and the second nasal assembly into the second nostril. The two nasal assemblies are typically of the same embodiment type, but as those skilled in the art will see, embodiments can be combined and matched to provide two different embodiment types that the user can insert into the nostrils.

[0083] The nasal assemblies in Figures 5A–5E may be heated externally before insertion into the nostrils. For example, the nasal assemblies may be heated in hot water, a microwave, or an oven. In some embodiments, the nasal assemblies may be sealed with various materials, such as materials that can be heat-activated by stirring and can maintain their heat for 1–4 hours. Examples of materials may include iron powder, salt, activated carbon, and / or vermiculite.

[0084] In some embodiments, the nasal assemblies of Figures 5A–5E may include electronic equipment (e.g., power supplies, sensors, antennas, and / or processors, as described in detail herein). In such examples, the nasal assemblies of Figures 5A–5E may use such electronic equipment to heat the assembly, monitor the assembly and / or the environment surrounding the assembly, and / or provide data associated with the heating of the assembly or other operations of the assembly.

[0085] When a heated nasal assembly is inserted into the nostril, heat transfer from the assembly to the nasal tissues and / or cavities can be achieved, which may trigger an increase or maintenance of EV in the nasal cavity while the assembly remains above the specified temperature as described herein, and / or for a period of time after the assembly is removed. In addition, the nasal assembly may further function to create a level of nasal congestion that promotes heat retention and generation, thereby potentially raising the internal temperature of the nostrils, nasal cavity, etc.

[0086] In some embodiments, the intranasal implants in the embodiments of Figures 5A–5E may be additively fabricated continuous grid structures configured to generate pressure on a portion of the surface of the nasal cavity when inserted into the nostrils, thereby partially narrowing the nostrils. For example, the intranasal implants and / or support structures described herein may be 3D printed components (e.g., intranasal implants, nose pads, etc.) having a grid structure that has sufficient resistance to generate heat and can optimize airflow through the nose. By being 3D printed, these components can be custom molded to comfortably fit the unique shape of the user's nostrils.

[0087] In some embodiments, one or more of the intranasal inserts in embodiments of Figures 5A–5E may function with or be used with one of the external devices described in embodiments of Figures 2A–4. For example, the bridge elements 252a and 252b in Figure 4 may monitor the outer skin surface of the nose 102. In such an example, the bridge elements 352a and 352b may not heat the nose, but instead may work in combination with an internal assembly 500 that can heat, for example, the inner surface of the nostril or nasal cavity. The bridge elements 352a and 352b may work together to achieve a target temperature within a given temperature range, as described herein.

[0088] Figure 5A shows an exemplary nasal assembly 500 for use in a user's nose. The nasal assembly 500 is shown as a substantially cylindrical, elongated, substantially hollow body (e.g., a tube, plug, or intranasal insert) and is configured to be at least partially positioned within the nostril. The nasal assembly 500 may be long enough to extend through the nasal vestibule into at least a portion of the nasal cavity.

[0089] The nasal assembly 500 includes a proximal end 502 and a distal end 504, and a longitudinal axis (L) extending through them. The proximal end 502 may correspond to the portion of the assembly 500 furthest from the opening of the nostril when the assembly 500 is installed inside the nostril. The nasal assembly 500 includes an outer surface 506 which may be positioned in contact with the nostril and a portion of the nasal cavity. The inner surface 508 included in the nasal assembly 500 defines a hollow region that allows air to flow into the nostril, through the assembly 500, and into the nasal cavity and lungs.

[0090] Figure 5B shows an exemplary nasal assembly 520 having one or more baffles (e.g., baffle 522). Similar to the nasal assembly 500, the nasal assembly 520 may be a substantially cylindrical, substantially hollow elongated body (e.g., a tube, plug, or intranasal insert) configured to be at least partially positioned within the nostril. The nasal assembly 520 may be long enough to extend through the nasal vestibule into at least a portion of the nasal cavity. The nasal assembly 520 includes an outer surface 524 which may be positioned in contact with the nostril and a portion of the nasal cavity. The inner surface 526 included in the nasal assembly 520 defines a hollow region that allows air to flow into the nostril, through the assembly 500, and into the nasal cavity and lungs.

[0091] The baffle 522 is provided along the outer surface 524 of the assembly 520 and may be defined as an opening through the outer surface 524 to the hollow portion and inner surface 526 of the nasal assembly 520. In some embodiments, the baffle 522 is a fixed perforation within the assembly 520. In some embodiments, the baffle 522 is unfixed. The baffle 522 may be formed as a flexible flap, slit, notch, or perforation that allows air to flow from the inner surface 526 of the assembly 520 to the outer surface 524 of the assembly 520. The baffle may provide at least two functions, one of which is to generate heat by restricting the airflow into the nose. Furthermore, in situations where the nasal assembly is heated before insertion into the nostril, the baffle can act as a heat exchanger, transferring its heat to the air flowing into the nose. This can increase the temperature of the internal tissues of the nose, thereby reducing viral replication and increasing the EV response. Baffle designs with flexible flaps, notches, slits, and perforations can restrict airflow while still allowing effective breathing through the nose, and can be optimized to maximize a predetermined level of heat to and / or exchange with the airflow as the preheated baffle material cools.

[0092] Figure 5C shows another exemplary nasal assembly 540 for use in a user's nose. The nasal assembly 540 is shown as a substantially elongated, rounded cone or bullet-shaped body (e.g., a plug, an intranasal insert, etc.), which is substantially hollow throughout and is configured to be at least partially positioned within the nostril. An aperture (not shown) may be located at the proximal end 542 and may be defined through the proximal end 542 to the distal end 544 of the assembly 540.

[0093] The nasal assembly 540 may be long enough to extend through the nasal vestibule into at least a portion of the nasal cavity. The nasal assembly 540 includes an outer surface 546 which may be positioned in contact with the nostrils and a portion of the nasal cavity. The inner surface (not shown) included in the nasal assembly 540 defines a hollow region that allows air to flow into the nostrils, through the assembly 540, and into the nasal cavity and lungs.

[0094] The nasal assembly 540 may have a substantially circular base 548 at its distal end 544. The base 548 may have a substantially circular perimeter surrounding a hollow region defined by an aperture (not shown). In some embodiments, the nasal assembly 540 may have an elliptical base 548 (or another shape) to accommodate various nostril sizes.

[0095] Although baffles are not shown on assembly 540, those skilled in the art can consider that any combination of baffles may be applied to assembly 540, as described herein.

[0096] Figure 5D shows yet another exemplary nasal assembly for use in a user's nose. The nasal assembly 560 is shown as a substantially bulbous tube that is substantially hollow throughout and can be at least partially positioned inside the nostril. An aperture 562 may be located at the distal end 564 and may be defined through the assembly 560 from the distal end 564 to the proximal end 566.

[0097] The nasal assembly 560 may be molded as a conventional pear or garlic clove shape, having a bulbous central portion 568 and a concave central portion 570 opposite the central portion 568. The nasal assembly 560 may be long enough to extend through the nasal vestibule into at least a portion of the nasal cavity. The nasal assembly 560 includes an outer surface 572 which may be positioned in contact with the nostrils and / or a portion of the nasal cavity. The inner surface (inside the tube 574) of the nasal assembly 560 defines a hollow region that allows air to flow into the nostrils, through the assembly 560, and into the nasal cavity and lungs. Although baffles are not shown on the assembly 560, those skilled in the art can consider that any combination of baffles may be applied to the assembly 560 as described herein.

[0098] Figure 5E shows the nasal assembly 500 within the nose 102. The left contour 580 of the nose 102 is shown. The left contour 580 is shown as a dashed line, indicating that the contour 580 is located inside the left nostril (e.g., inside the left nostril). The left contour 580 is located within the first part of the nasal cavity of the nose 102 (e.g., the left nostril N1). Similarly, the right contour 582 of the nose 102 is shown. The right contour 582 is shown as a dashed line, indicating that the contour 582 is located inside the right nostril (e.g., inside the right nostril). The right contour 582 is located within the second part of the nasal cavity of the nose 102 (e.g., the right nostril N2).

[0099] In this example, the outer surface 524 of the nasal assembly 500A (Figure 5A) may be configured to heat the left nostril N1 having a left contour 580 when the assembly 500A is preheated (or configured to be electronically heated). The left nostril N1 may have tissue portions covered by at least one mucus layer. These tissue portions and / or at least one mucus layer may also be heated by the nasal assembly 500A. Similarly, the outer surface 524 of the nasal assembly 500B (Figure 5A) may be configured to heat the right nostril N2 having a right contour 582 when the assembly 500B is preheated (or electronically heated).

[0100] Heating / warming of the outer surfaces of assemblies 500A, 500B (and subsequently heating of the nostrils N1, N2 and / or the corresponding nasal cavity(s)) may be carried out until a predetermined temperature range is reached. For example, the predetermined temperature range may be approximately 37 degrees Celsius (approximately 98.6 degrees Fahrenheit) to approximately 39 degrees Celsius (approximately 102.2 degrees Fahrenheit). In some embodiments, the predetermined temperature range may be modified, as will be described in detail throughout this disclosure. The left nostril N1 may have tissue portions covered by at least one mucus layer. These tissue portions and / or at least one mucus layer may also be warmed by the nasal assembly 500A when assembly 500A is positioned in contact with the left contour 580. Similarly, the right nostril N2 may have tissue portions covered by at least one mucus layer. These tissue portions and / or at least one mucus layer may also be heated by the nasal assembly 500B when the assembly 500B is positioned in contact with the right contour 582.

[0101] In some embodiments, the nasal assembly 500A and / or the nasal assembly 500B may include a sensor (e.g., sensor 804) adapted to contact at least a portion of the nasal cavity. For example, at least one sensor 804 may be mounted on a portion of the assembly 500A (and / or 500B). The sensor 804 may monitor a portion of the nasal cavity. In some embodiments, the sensor 804 may be powered by a power supply (e.g., power supply 814) mounted on the assembly 500A and / or the assembly 500B. In this example, the power supply may be electrically coupled to an electronic heat source (e.g., heat source 802) and the sensor 804.

[0102] Figures 6A-6B show exemplary embodiments of a nasal assembly 600 for warming and monitoring a portion of the nose. The nasal assembly may consist of two or more components that can work together to warm at least a portion of the internal nasal cavity 104 to suppress viral replication within the nasal cavity.

[0103] Figure 6A shows a jewelry component 600A that may be part of a nasal assembly 600 for heating and / or monitoring a portion of the nose (e.g., the nasal cavity). The nasal assembly 600 may represent a wearable system for heating the nasal cavity. The wearable system may include at least one processor (e.g., processor 810), at least one sensor (e.g., sensor 804), and a heat source (e.g., heat source 802).

[0104] The jewelry component 600A includes a sensor 602 adapted to be positioned adjacent to a portion of the nose. A sensor 804 may be installed within the jewelry component 600A. The jewelry component 600A may be configured to be positioned within a nose piercing associated with the nose, so that when the jewelry is fitted into the nose piercing, the sensor 804 comes into contact with the portion of the nasal cavity to be monitored. The sensor 602 may be configured to sense the temperature of the portion of the nose and to wirelessly output the sensed temperature to a processor (e.g., processor 810). In some embodiments, the sensor 602 and / or processor 810 may use one or more antennas 604 (e.g., antenna circuit 808) configured to wirelessly communicate with a mobile computing device (e.g., device 101 and / or other computing devices). Wireless communication may include temperature output, commands, and / or the status of the nose assembly, the status of the sensor, etc.

[0105] The jewelry component 600A shown herein may be a nose piercing, but those skilled in the art can consider that component 600A may not be a piercing, but rather a magnetized two-part element. The first element is located inside the nostril, and the second element may be magnetized relative to the first element when placed on a skin area opposite to the position of the first element inside the nostril.

[0106] Figure 6B shows the spectacle component 600B of the nose assembly 600 for heating and / or monitoring a portion of the nose. The spectacle component 600B may be similar to the spectacle 300 and nose assembly 302. Component 600B includes a heat source 610 which can be communicatively coupled to the sensor 602 and processor (e.g., processor 810) of component 600A. As shown in Figure 6B, the heat source 610 is positioned in contact with the contour of the nose 102 (e.g., the bridge of the nose). Those skilled in the art can consider that the heat source 610 may be positioned in different locations on the nose, as will be described in detail herein. In addition, those skilled in the art can consider that the heat source 610 may alternatively be positioned on the jewelry component 600A instead of the spectacle component 600B. In such an example, the heat source 610 may be a piece of jewelry 102 configured to be placed inside a nose piercing associated with the nose, so that when the jewelry (e.g., jewelry component 600A) is fitted inside the nose piercing, the heat source 610 comes into contact with a portion of the nasal cavity associated with the nose 102. The heat source 610 configured as jewelry may be configured to heat the inner surface of the nose 102 (e.g., at least a portion of the nasal cavity) in response to a sensor (e.g., sensor 602) detecting that the temperature of the nose 102 is outside a target temperature range (e.g., a predetermined temperature range as defined herein).

[0107] Furthermore, those skilled in the art may consider alternatively placing a separate heat source 610 on both the jewelry component 600A and the eyeglass component 600B to selectively heat one or both of the inner or outer surfaces of the nose 102 until a predetermined (e.g., target) temperature or temperature range is reached.

[0108] A processor 810 within an exemplary nasal assembly 600 may be part of component 600A or component 600B. In some embodiments, each component 600A, 600B includes a separate, independent processor 810. In such examples, the separate processors 810 may be communicatively coupled. One or more processors 810 of the nasal assembly 600 may be configured to receive a detected temperature of the nose 102 (and / or nasal cavity) from a sensor 602 and cause a heat source 610 to change the temperature of the nasal cavity based on the detected temperature of the nose 102 (and / or nasal cavity). For example, one or more processors 810 may selectively operate a heat source 610 (associated with a component, based on the detected temperature of the environment surrounding the wearable system).

[0109] Figure 7 shows an exemplary embodiment of a nose assembly 700 for heating and / or monitoring a portion of the nose. The nose assembly 700 includes an eyeglass component 700A and an internal component 700B. The eyeglass component 700A may be similar to eyeglasses 300 and the nose assembly 302. In this example, the eyeglass component 700A may include a sensor 702. For example, the sensor 702 is located in the bridge member 704 of the eyeglass component 700A as shown herein. In some embodiments, component 700B includes a sensor (not shown). In some embodiments, both the eyeglass component 700A and component 700B include sensors.

[0110] In some embodiments, the eyeglass component 700A may also include a heat source 706 which can be communicatively coupled to a sensor 702 and one or more processors (e.g., processor 810). As shown in Figure 7, the heat source 706 is positioned in contact with the contour of the nose 102 (e.g., the bridge of the nose). Those skilled in the art can consider that the heat source 706 may be positioned at different locations on the nose, as will be described in detail herein. In addition, those skilled in the art can consider that the heat source 706 may alternatively be positioned on component 700B instead of eyeglass component 700A. Furthermore, those skilled in the art can consider that a separate heat source 706 may alternatively be positioned on both component 700A and component 700B to selectively heat one or both of the inner or outer surfaces of the nose 102 until a predetermined (e.g., target) temperature or temperature range is reached.

[0111] A processor 810 within an exemplary nasal assembly 700 may be part of component 700A or component 700B. In some embodiments, each component 700A, 700B includes a separate, independent processor 810. In such examples, the separate processors 810 may be communicatively coupled. One or more processors 810 of the nasal assembly 700 may receive a detected temperature of the nose 102 (and / or nasal cavity) from a sensor 702 and cause a heat source 706 to change the temperature of the nasal cavity based on the detected temperature of the nose 102 (and / or nasal cavity). For example, one or more processors 810 may selectively operate the heat source 706.

[0112] In an example where the sensor is contained on internal component 700B and adapted to be fitted inside a portion of the nasal cavity, the sensor 702 may monitor the internal temperature of the nasal cavity and wirelessly communicate with the processor and heat source to trigger heating of the nasal cavity until the temperature reaches a target temperature range.

[0113] Figure 8 shows an exemplary system 800 for heating and monitoring a portion of the nose. System 800 may be a nasal assembly as described in Figures 2A to 7 of this disclosure. System 800 may be communicatively coupled to one or more mobile devices and / or computing devices 801. For example, System 800 may provide temperature data, status data, message data, and / or other operational data to one or more devices 801. One or more devices 801 may provide commands, instructions, and / or operational data to System 800. In some embodiments, one or more devices 801 may provide data, commands, and / or status update information to System 800 via wireless communication, as described in detail herein.

[0114] As shown in Figure 8, the system 800 includes a heat source 802. The heat source 802 may heat one or more components of the system 800 to heat the inner or outer surface of the nose. In some embodiments, the heat source 802 may heat the nose using one or more radio frequency (RF) heating elements that can transfer energy from a nasal assembly (shown in Figures 2A to 7) into or over the nose. One or more RF heating elements may operate in the range of about 30 MHz to about 120 MHz.

[0115] In some embodiments, the heat source 802 may use one or more ultrasonic heating elements to warm the nose. One or more ultrasonic heating elements may operate at frequencies of about 2 MHz to about 4 MHz. In some embodiments, the frequency may be about 3 MHz.

[0116] In some embodiments, the heat source 802 may use one or more electromagnetic heating elements to warm the nose. One or more electromagnetic heating elements may function at frequencies from about 902 MHz to about 928 MHz.

[0117] In some embodiments, the heat source 802 may heat the nose using a small Peltier heater utilizing a thermoelectric element (TED). In some embodiments, the heat source 802 may heat the nose using one or more infrared light-emitting diodes. In some embodiments, the heat source 802 may heat the nose using a solid heat pump with thermally conductive graphene. In some embodiments, the heat source 802 may heat the nose using one or more micro-electromechanical (MEM) microheat pumps. In some embodiments, the heat source 802 may heat the nose using microwave-safe clay or other material that can be preheated and retain heat for several hours. In some embodiments, the heat source 802 may heat the nose using a material that is activated when the material is stirred. Examples of materials may include iron powder, salt, activated carbon, and / or vermiculite.

[0118] System 800 may include one or more sensors 804 (for example, sensor 354, sensor 602, sensor 702). One or more sensors 804 may include temperature sensors, pressure sensors, tissue impedance sensors, and / or ambient temperature sensors. Temperature sensors may include, but are not limited to, infrared sensors, thermometers, thermistors, or heat flux transducers. One or more sensors 804 may be placed on or inside bridge elements, support members, and / or other elements associated with any of the nasal assembly devices described herein (for example, system 800).

[0119] In some embodiments, one or more sensors 804 may be adapted to be fitted within a portion of the nasal cavity. For example, one or more sensors 804 may be positioned on one or more support members of a particular nasal assembly. Once one or more support members are inserted into the nasal cavity, one or more sensors 804 may begin to detect and provide status 820 to, for example, device 801. In some embodiments, one or more sensors 804 may be installed within a bridge member of a particular nasal assembly that can be fitted over the nose.

[0120] The system 800 includes a communication module 806 that enables communication with one or more mobile devices or computing devices 801. An antenna circuit 808 may enable the system 800 to wirelessly communicate with one or more devices 801. For example, the communication module 806 may include an antenna circuit 808 (e.g., one or more antennas or coils) for wireless connectivity (e.g., Bluetooth, Wi-Fi, radio frequency (RF), or other short-range wireless communication protocols, without limit). In some embodiments, the communication module 806 may also enable cellular data services to the system 800. The communication module 806 may also include components for wired connectivity (e.g., USB data transfer).

[0121] System 800 may include one or more processors 810 coupled to memory 812 and power supply 814. The one or more processors 810 may include one or more hardware processors, such as microcontrollers, digital signal processors, application-specific integrated circuits (ASICs), field-programmable gate arrays (FPGAs) or other programmable logic devices, discrete gate or transistor logic, discrete hardware components, or any combination thereof, designed to perform the functions described herein and / or capable of executing instructions such as instructions stored by memory 812. The processors 810 may also execute instructions for performing communication between the nose assembly (e.g., system 800), sensor 804, and / or device 801 as described herein.

[0122] Memory 812 may include one or more non-temporary computer-readable storage media. Memory 812 may store instructions and data that can be used in conjunction with processor 810 to execute a process (for example, process 900). Memory 812 may also store or allow access to sensor data, status 820 (for example, status data), and command 822.

[0123] System 800 may further include (or be communicatively coupled to) input devices (not shown), output devices (not shown), and / or power supplies 814. Input devices may communicate with one or more processors 810, memory 812, and / or sensors 804. Input devices may include buttons, touchscreens, switches, toggles, and / or other hardware components located on System 800. In some embodiments, input devices may be external to or not integrated into System 800, so one or more controllers, mobile devices (e.g., mobile device 801), etc., may communicate with System 800 using wireless communication protocols.

[0124] Power supply 814 may include, or may be connected to, a battery or a port for connecting system 800 to a power supply, external battery, wall power adapter, etc.

[0125] During the operation of system 800 (for example, nasal assembly 200C), the heat source 802 may begin to heat (or receive a command to heat) a portion of the nose 102 that is in contact with the support members 230, 232. Heating a portion of the nose 102 may further heat one or more internal portions of the nose 102 that are located within the nose and opposite the external anatomical region of the nose. Assembly 200C may heat a portion of the nose 102 until a predetermined external or internal nasal temperature is reached, as described in detail herein.

[0126] In addition, the nasal assembly 200C may include one or more sensors 804, a power supply (e.g., power supply 814), and / or a processor (e.g., a processor 810 (programmed to execute monitoring instructions, communication instructions, and / or other device operation instructions)). For example, the nasal assembly 200C may include one or more sensors 804 coupled to the processor 810. One or more sensors 804 may be adapted to be positioned adjacent to or in contact with a portion of the nose 102. One or more sensors 804 may be configured to sense the temperature of a portion of the nose 102 and wirelessly output the sensed temperature to the processor 810 via an antenna circuit 808.

[0127] In some embodiments, one or more sensors 804 may output detected temperature and / or status 820 to one or more devices 801, either additionally or alternatively. Device 801 may provide a command 822 (e.g., command data) in response to status 820 and / or in response to receiving a specific temperature from sensor 804.

[0128] One or more sensors 804 may include, for example, at least one temperature sensor for monitoring the ambient temperature around the nasal assembly 200C, and may transmit a signal to a heat source 802 to selectively activate the heat source 802 based on the ambient temperature around the nasal assembly 200C.

[0129] For example, one or more devices 801 may monitor the temperature of a portion of the nasal cavity in preparation for generating a command that can trigger a programmed process in the system 800 to heat (e.g., warm) a portion of the nasal cavity. For example, one or more devices 801 may receive the surface temperature of a portion of the nasal cavity 104 from a sensor 804 and / or a processor 810. In response to detecting that the surface temperature of a portion of the nasal cavity is below or outside a predetermined temperature range, as described herein, one or more devices 801 may activate a heat source 802 to perform a heating cycle.

[0130] As described herein, in response to detecting that the surface temperature of a portion of the nasal cavity 104 exceeds a predetermined temperature, one or more devices 801 may deactivate the heat source 802. Monitoring can continue until the heating cycle is triggered again.

[0131] An exemplary heating cycle may operate to indefinitely heat a portion of the nose and / or a portion of the nasal cavity until a power loss is detected or for a programmed period (without limitation including at least one of approximately 2 minutes to approximately 60 minutes, approximately 2 minutes to approximately 10 minutes, approximately 10 minutes to approximately 40 minutes, and approximately 40 minutes to approximately 60 minutes).

[0132] In some embodiments, the heating cycle may operate to heat a portion of the nose and / or nasal cavity at a rate per minute, per hour, or per day. In some embodiments, the heating cycle may operate to heat a portion of the nose and / or nasal cavity based on a recipe that indicates a time-specified heating instruction / command, at least in part on which particular pathogen (e.g., virus, bacterial pathogen) is being acted upon to reduce replication. Such a recipe may be determined using artificial intelligence algorithms and / or machine learning models.

[0133] In some embodiments, the heating cycle may be performed according to a pre-programmed schedule. For example, the assemblies described herein may function automatically based on the detection of biological tissue and / or act according to a pre-programmed schedule when power is applied or the switch is turned on. In some embodiments, the heating cycle may be performed according to a user-programmed duration and user-programmed temperature.

[0134] In some embodiments, the heating cycle described herein may be automatically initiated in response to the detection of available power to the heat source. In some embodiments, the heating cycle described herein may be automatically initiated in response to the detection of contact with skin or nasal passage tissue. In some embodiments, the heating cycle described herein may be automatically terminated in response to the detection of the absence of skin or nasal passage tissue. In some embodiments, the heating cycle described herein may be executed according to a schedule in which time is specified based on an onboard clock or onboard timer device. In some embodiments, the heating cycle described herein may be executed according to user programming, user input, or other user-based requests for operating the heating cycle using one or more of the assemblies described herein.

[0135] In some embodiments, the bridge member 234 may include or be coupled to an antenna circuit 808 (Figure 8) configured to wirelessly communicate with at least one external computing device 801 (Figure 8), thereby allowing the computing device 801 to wirelessly operate the nasal assembly 200C, as detailed in Figure 8. Such a circuit may enable wireless monitoring using a sensor 804 to monitor and / or change the temperature of the nasal assembly 200C, the internal temperature of the nose, the external temperature of the nose, and / or the ambient temperature of the area surrounding the nasal assembly.

[0136] Embodiments of devices / assemblies described herein may include nasal assemblies formed from a variety of materials. For example, support structures and / or intranasal inserts described herein may be substantially formed from thermal insulating materials that also provide biocompatibility and / or washability. Such materials may, without limitation, include: polyether ether ketone (PEEK), nitinol® styrene ethylene butylene styrene (SEBS), silicone, polycarbonate (PC), polystyrene (PS), high-density polyethylene (HDPE), low-density polyethylene (LDPE), polyethylene (PE), polypropylene (PP), poly(methyl methacrylate) (PMMA), polyethylene terephthalate glycol (PETG), polyvinyl chloride (PVC), acrylonitrile butadiene styrene (ABS), nylon, polyamide-imide (PAI), polybenzimidazole (PBI), polyimide (PI), thermoplastic polyurethane (TPU), and / or elastomer film polymers, foams, and / or combinations thereof.

[0137] In some embodiments, the intranasal implants and / or support structures described herein are additively fabricated continuous grid structures configured to generate pressure against a portion of the surface of the nasal cavity when inserted into the nostrils, thereby partially narrowing the nostrils. For example, the intranasal implants and / or support structures described herein may be 3D printed components (e.g., nasal implants, nasal pads, etc.) having a grid structure that has sufficient resistance to generate heat and can optimize airflow through the nose. By being 3D printed, these components can be custom molded to comfortably fit the unique shape of the user's nostrils.

[0138] Bridge components and / or jewelry may be formed from any one of the above materials and / or metals, such as gold, silver, platinum, stainless steel, titanium, aluminum, nickel, Monel®, gemstones, diamonds, or combinations thereof.

[0139] The support members of the devices described herein may include a surface area sized to cover any portion of the outer surface of the nose. For example, the support member may have a width and length that can fit within a portion of the outer contour of the nose. In some embodiments, the support member described herein may have a width and length that can fit within a portion of the inner contour of the nose. For example, the support member described herein may be sized to have the following widths: about 12.7 mm to about 31.8 mm, about 12.7 mm to about 15 mm, about 15 mm to about 20 mm, about 20 mm to about 25 mm, about 25 mm to about 30 mm, or about 30 millimeters to about 31.8 mm. In some embodiments, the width may be sized by the end user before the device described herein is fitted. For example, the support member described herein may have a modifiable circumference that can be cut, folded, or otherwise modified to change the shape of the support member before the user attaches the surface of the support member to the nose.

[0140] Similarly, the support members described herein may be sized to have the following lengths: approximately 12.7 mm to approximately 31.8 mm, approximately 12.7 mm to approximately 15 mm, approximately 15 mm to approximately 20 mm, approximately 20 mm to approximately 25 mm, approximately 25 mm to approximately 30 mm, or approximately 30 millimeters to approximately 31.8 mm. In some embodiments, the length may be sized by the end user before wearing the device described herein. For example, the support members described herein may have a modifiable circumference that can be cut, folded, or otherwise modified to change the shape of the support member before the user attaches the surface of the support member to the nose.

[0141] In some embodiments, the length of the support member may differ from its width. For example, the length may be about 1.2 times the width, about 1.5 times the width, or about 2.0 times the width.

[0142] The support members described herein may be sized to have the following depths: approximately 0.5 mm to approximately 5 mm, approximately 0.5 mm to approximately 1 mm, approximately 1 mm to approximately 1.5 mm, approximately 1.5 mm to approximately 2 mm, approximately 2 mm to approximately 2.5 mm, approximately 2.5 mm to approximately 3 mm, approximately 3 mm to approximately 3.5 mm, approximately 3.5 mm to approximately 4 mm, approximately 4 mm to approximately 4.5 mm, or approximately 4.5 mm to approximately 5 mm. The support members described herein may be flexible members that conform to a portion of the nose. In some embodiments, the depth of the support member may vary across the surface of the support member, taking into consideration electronic devices, batteries, heat sources, etc.

[0143] In some embodiments, the devices described herein may be configured to be stored and powered within a case. For example, the battery source of the nasal assembly described herein may be adapted to be charged within a case designed to hold and protect the assembly. The case may charge the assembly via a wired or wireless method. In some embodiments, the case may result in heating of the nasal assembly so that the nasal assembly can perform nasal cavity heating based on dissipating heat from a preheated state, even though it may not normally be powered. method

[0144] As shown in Figure 9, a process for reducing viral replication in the nasal mucosa and / or extending EV effectiveness may include monitoring, determining, and adjusting and / or maintaining the temperature associated with the nose. Process 900 works to ensure that the nasal cavity and / or nasal mucosa of the nose are within a given temperature range, thereby ensuring a reduction in viral and / or bacterial replication within the nose. Process 900 is generally used to mitigate disease and disease severity, but can be used additionally or as an alternative to any appropriate application (clinical or other). Process 900 can be configured and / or adapted to work for any appropriate warming method for a part of the body. For example, Process 900 could be used to warm a patient during surgery that operates by increasing energy levels and / or temperature, potentially raising the body's core temperature, potentially preventing hospital-acquired infections, and thus Process 900 could be used in combination with other conventional methods.

[0145] Process 900 can be used in conjunction with any of the internal and external devices described herein (e.g., nasal assemblies) to increase the temperature inside the nose (including the inferior turbinates). In some embodiments, the devices described herein may be used, for example, to heat a patient's airway for therapeutic purposes in clinical conditions where increasing the airway temperature is desirable. Assembly 200A and assembly 500 may be used as examples in the process described below, but one or more of the nasal assemblies described herein may be used instead.

[0146] In block 902, process 900 includes providing a device that contacts the contour of the user's nose. For example, the device (e.g., assembly) may include one or more of assemblies 200A, 200B, 200C, 300, 350, 500, 520, 540, 560, 600, and / or 700. Each device used in process 900 may include a heating assembly (e.g., heat source 802) and a temperature sensor (e.g., sensor 804). Each device may at least partially restrict or limit the airflow into the nose. For example, at least partially restricting or limiting the airflow into the nose may include at least partially blocking the nostrils. In some embodiments, at least partially restricting or limiting the airflow into the nose may include at least partially blocking both the right and left nostrils. For example, if the device is an internal assembly (e.g., nasal assembly 500), the device may at least partially restrict or block a portion of the nostril in which the assembly is located. However, if the device is an external assembly (e.g., nasal assembly 200A), the device may at least partially restrict or block the amount of air entering the nostril by applying pressure to one or both nostrils, the bridge of the nose, the sides of the bridge of the nose, or one or more side walls of the nose.

[0147] In block 904, process 900 includes monitoring the temperature of a portion of the nose by a temperature sensor 804. For example, the temperature sensor 804 may be electrically coupled to the nasal assembly 200A. The temperature sensor 804 may detect the temperature of the outer side wall of the nose located beneath, in contact with, or proximal to a specific support member (e.g., support member 202, support member 204). In some embodiments, the temperature sensor 804 may detect the temperature around the nasal assembly 200A. In some embodiments, the temperature sensor 804 may detect the temperature of the nasal cavity when, for example, the assembly 500 is operating inside the nostril.

[0148] The detected temperature(s) can activate nasal assembly 200A or nasal assembly 500 to change the temperature profile of the thermal cycle. In some embodiments, the detected temperature(s) can activate nasal assembly 200A or nasal assembly 500 to change the temperature (or temperature range) to be reached. In some embodiments, the detected temperature(s) can activate nasal assembly 200A or nasal assembly 500 to change other functions of assemblies 200A, 500.

[0149] In block 906, process 900 includes detecting, using a temperature sensor, whether the temperature of a portion of the nose is below a predetermined temperature range. For example, sensor 804 may work in conjunction with processor 810 to detect whether the temperature of a portion of the nose has fallen below a predetermined temperature range.

[0150] If the device is an internal assembly (e.g., nasal assembly 500), part of the nose may include the inferior turbinate (Figure 1), and the given temperature range may be approximately 37 degrees Celsius (approximately 98.6 degrees Fahrenheit) to approximately 39 degrees Celsius (approximately 102.2 degrees Fahrenheit). If the device is an external assembly (e.g., nasal assembly 200A), part of the nose may include the nasal vestibule (Figure 1), and the given temperature range may be approximately 41 degrees Celsius (approximately 105.8 degrees Fahrenheit) to approximately 43 degrees Celsius (approximately 109.4 degrees Fahrenheit).

[0151] In response to detecting that the temperature of the internal or external portion of the nose is below a predetermined temperature range, process 900 includes activating a heating assembly (e.g., a heat source 802) to raise the temperature of the portion of the nose to within the predetermined temperature range. In short, when a temperature outside the predetermined temperature range is detected, a heat source associated with the assembly performing the temperature measurement (coupled to sensor 804) may be automatically activated.

[0152] If the temperature of the internal or external portion of the nose is detected to be within a predetermined temperature range, process 900 may include deactivating the heating assembly (e.g., heat source 802). In addition, process 900 may also deactivate the heating assembly (e.g., heat source 802) when the portion of the nose reaches a temperature within a predetermined temperature range.

[0153] In some embodiments, the assembly described herein includes an antenna circuit (e.g., antenna circuit 808) configured to wirelessly communicate with at least one external computing device (e.g., one or more devices 801), thereby enabling at least one external computing device (e.g., one or more devices 801) to operate the assembly wirelessly. Temperature data, commands 822, status 820, etc., may be transmitted from the assembly described herein to one or more external devices (e.g., devices 801).

[0154] In block 908, process 900 includes maintaining the temperature of a portion of the nose within a predetermined temperature range until it receives a signal to deactivate the heating assembly. For example, sensor 804, in combination with processor 810 (which is programmed to execute, for example, monitoring instructions, communication instructions, and / or other device operation instructions), may, for example, monitor the temperature of the environment surrounding a portion of assembly 500 and, based on the detected temperature of the environment surrounding the portion of assembly 500, send a signal to the heating assembly (for example, heat source 802) to selectively activate the heating assembly (for example, heat source 802). In some embodiments, the processor 810 (programmed to execute, for example, monitoring instructions, communication instructions, and / or other device operation instructions) may, for example, monitor the temperature of one or more nasal portions and / or nasal cavities substantially adjacent to (e.g., in close proximity to or in contact with) assembly 300 (or assembly 200A or assembly 500), and based on the temperature detected for one or more nasal portions and / or nasal cavities substantially adjacent to assembly 300 (or assembly 200A or assembly 300), send a signal to the heating assembly (e.g., heat source 802) to selectively activate the heating assembly (e.g., heat source 802).

[0155] The systems and methods described herein, and their variations thereof, can be at least partially embodied and / or implemented as machines configured to receive computer-readable media storing computer-readable instructions. Instructions may be executed by computer-executable components integrated into the system and one or more parts of the processor on the nose assembly and / or computing device 801 described herein. The computer-readable media may be stored on any suitable computer-readable media, such as RAM, ROM, flash memory, EEPROM, optical devices (e.g., CD or DVD), hard drives, floppy drives, or any suitable device. The computer-executable components may include any suitable dedicated hardware or hardware / firmware combinations that can perform the instructions alternatively or additionally.

[0156] Wherever "one embodiment," "embodiment," "exemplary embodiment," or "some embodiments" is used in this specification, it indicates that the described embodiments may include certain features, structures, or characteristics, but not all embodiments may include or may not include those features, structures, or characteristics. Furthermore, such phrases do not necessarily refer to the same embodiment. Moreover, where certain features, structures, or characteristics are described in relation to an embodiment, it is assumed that the influence of such features, structures, or characteristics in relation to other embodiments, whether explicitly stated or not, is within the knowledge of those skilled in the art.

[0157] When used in the specification and claims, the singular forms “a,” “a,” and “the” include both singular and plural references unless the context clearly indicates otherwise. For example, the term “sensor” may and is intended to include multiple sensors. While claims and disclosures may sometimes include terms such as “multiple,” “one or more,” or “at least one,” the absence of such terms is not intended, nor should it be interpreted, as meaning that the plural has not been conceived.

[0158] The terms “approximately” or “about” when used before a numerical specification or range (for example, to specify length or pressure) indicate an approximation that may vary by only (+) or (-) 5%, 1%, or 0.1%. All numerical ranges provided herein include the stated starting and ending numbers. The term “substantially” refers to the majority (i.e., greater than 50%) or essentially all of a device, substance, or composition.

[0159] As used herein, the terms “comprising” or “comprises” are intended to mean that a device, system, and method includes the elements described and may include any other elements. “Essentially consisting of” means that a device, system, and method includes the elements described and does not include any other elements that are essentially important to the combination for the described purpose. Thus, a system or method that is essentially consisting of the elements defined herein does not exclude any other materials, features, or steps that do not substantially affect the basic and novel characteristics of the claimed disclosure. “Consists of” means that a device, system, and method includes the elements described and excludes anything other than trivial or non-essential elements or steps. Embodiments defined by each of these transitional terms are within the scope of this disclosure.

[0160] The examples and figures included herein illustrate, and not limit, specific embodiments in which the subject matter may be carried out. Structural and logical substitutions and modifications may be made without departing from the scope of this disclosure by utilizing and deriving from other embodiments. Such embodiments of the disclosed subject matter may be referred to separately or collectively in this specification by the term “invention” for convenience only, but even if multiple are actually disclosed, this application is not intended to spontaneously limit the scope to any single invention or inventive concept. Accordingly, although specific embodiments are illustrated and described herein, any arrangement calculated to achieve the same purpose may be used in place of the specific embodiments shown. This disclosure is intended to cover all adaptations or variations of various embodiments. Combinations of the embodiments described herein, and other embodiments not specifically described herein, will be apparent to those skilled in the art by considering the foregoing description.

Claims

1. A nasal assembly, A first support member having a first surface configured to substantially conform to the left contour of the nose when the nasal assembly is fitted, A second support member having a second surface configured to conform to the right contour of the nose when the nasal assembly is fitted, A heat source electrically coupled to the first support member and the second support member, the heat source being configured to adjust the surface temperatures of the first surface and the second surface to heat the left contour of the nose and the right contour of the nose to a predetermined temperature range, The first support member and the second support member are connected to a compression bridge member configured to compress the upper part of the nose when the nasal assembly is fitted, thereby at least partially restricting a portion of the airflow through the passages within the nose. A nasal assembly in which the replication of viral cells in the nose is reduced by the aforementioned heating and compression.

2. The aforementioned nasal assembly further includes: The nasal assembly according to claim 1, comprising an antenna circuit configured to wirelessly communicate with at least one external computing device so that the at least one external computing device can wirelessly operate the nasal assembly.

3. The left contour and the right contour of the nose are the external anatomical regions of the nose. The first surface and the second surface are configured such that when the first surface and the second surface are heated, one or more internal portions of the nose are heated to a second predetermined temperature range. The nose assembly according to claim 1, wherein the one or more internal portions of the nose are located opposite the external anatomical region of the nose at the positions of the left contour and the right contour of the nose, respectively.

4. The external anatomical region of the nose includes at least one surface of the nasal bridge, left lateral nasal wall, right lateral nasal wall, paranasal cartilage, or nasal septal cartilage. The nasal assembly according to claim 3, wherein by heating the first surface and the second surface, one or more internal parts of the nose are heated to a second predetermined temperature range, and the one or more internal parts of the nose are located opposite the respective nasal bridge, the left nasal wall, the right nasal wall, the paranasal cartilage, or the nasal septum cartilage.

5. The aforementioned predetermined temperature range is approximately 41 degrees Celsius to approximately 43 degrees Celsius. The nasal assembly according to claim 3, wherein the second predetermined temperature range is approximately 37 degrees Celsius to approximately 39 degrees Celsius.

6. The nasal assembly according to claim 1, wherein the first support member is connected to the second support member by the compression bridge member, and the compression bridge member has a substantially C-shaped structure.

7. The nose assembly according to claim 1, wherein the nose assembly is configured to be detachably attached to the lens of an eyeglass.

8. The nasal assembly according to claim 1, wherein at least partially restricting a portion of the airflow through the passage within the nose includes at least partially narrowing at least one nostril of the nose.

9. The nasal assembly according to claim 1, further enabling the nasal assembly to efficiently maintain the temperature of the nasal mucosa within the nose by at least partially restricting a portion of the airflow through the passage within the nose.

10. The aforementioned nose assembly is eyeglasses, and the aforementioned nose assembly further, The battery charger is used to provide continuous heating to the nasal assembly, and the battery charger is One or more rechargeable batteries are electrically coupled to the heat source, and are positioned on the temple portion of the eyeglasses. The nose assembly according to claim 1, wherein the temple portion is configured to receive a power attachment connection.

11. The nose assembly according to claim 1, wherein heating the left contour of the nose and the right contour of the nose to the predetermined temperature range includes heating the nasal vestibule.

12. The nasal assembly according to claim 1, wherein heating the left contour of the nose and the right contour of the nose to the predetermined temperature range is performed according to a heating cycle selected based at least partially on the indicated pathogen.

13. The nose assembly according to claim 1, further comprising a second heat source coupled to the compression bridge member and configured to heat the nasal bridge while the first heat source heats the left contour and the right contour, wherein the compression bridge member comprises a first end and a second end, the first end coupled to the first support member and the second end coupled to the second support member.

14. The nasal assembly according to claim 1, wherein the heat source is an ultrasonic heat source operating in a frequency range of approximately 2 MHz to approximately 4 MHz.

15. The nasal assembly according to claim 1, wherein heating the left contour and the right contour of the nose and compressing the upper part of the nose further increases the generation of extracellular vesicles in the nasal mucosa of the nose.

16. The nasal assembly according to claim 1, wherein the compression bridge member is formed of a shape memory material that allows for flexible movement to apply force to the nose.

17. A wearable system for warming the nasal cavity, the wearable system is Processor and A sensor adapted to be positioned adjacent to a portion of the nose, configured to detect the temperature of the portion of the nose and to wirelessly output the detected temperature to the processor, A heat source, which is communicably coupled to the sensor and the processor, wherein the heat source is positioned in contact with the contour of the nose, includes The heat source is coupled to a bridge member configured to compress the contour of the nose when the wearable system is worn, thereby at least partially restricting a portion of the airflow through the passage within the nose. The processor is configured to receive the detected temperature of the nose and to cause the heat source to change the temperature of the nasal cavity based on the detected temperature of the nose. A system in which the replication of viral cells in the nose is reduced by the aforementioned change in temperature and the aforementioned compression of the contour of the nose.

18. The system according to claim 17, further comprising one or more antennas configured to wirelessly communicate with a mobile computing device and selectively activate the heat source based on the detected temperature of the environment surrounding the wearable system.

19. A method for reducing viral replication within nasal cells, wherein the method is This involves providing a wearable device, the wearable device being: A first support member having a first surface configured to substantially conform to the left contour of the user's nose, A second support member having a second surface configured to follow the right contour of the nose, A temperature sensor coupled to a part of the wearable device, A heat source electrically coupled to the first support member and the second support member, wherein the heat source is configured to adjust the surface temperatures of the first surface and the second surface to heat the left contour and the right contour of the nose to a predetermined temperature, and the first support member and the second support member are coupled to a compression bridge member configured to compress a part of the nose and at least partially restrict a part of the airflow through the passage inside the nose, including the heat source. The temperature sensor is used to monitor the temperature of the part of the nose, In response to the temperature sensor detecting that the temperature of a portion of the nose is below a predetermined temperature, the heat source is activated to raise the temperature of that portion of the nose to within the predetermined temperature range. A method comprising maintaining the temperature of the part of the nose within the predetermined temperature range until a signal is received to stop the operation of the heat source.

20. The method according to claim 19, wherein the generation of extracellular vesicles in the nasal mucosa of the nose is increased by heating the left contour and the right contour of the nose and compressing a part of the nose.

21. The method according to claim 19, wherein the compression bridge member is formed of a shape memory material that allows for flexible movement to apply force to the nose.

22. The method according to claim 19, wherein at least partially restricting a portion of the airflow through the passage in the nose includes at least partially narrowing at least one nostril of the nose.

23. The method according to claim 19, further enabling the wearable device to efficiently maintain the temperature of the nasal mucosa in the nose by at least partially restricting a portion of the airflow through the passage in the nose.

24. The wearable device is a pair of glasses, and the wearable device further comprises: The system includes a battery charger for generating continuous heating for the wearable device, and the battery charger is One or more rechargeable batteries, the temperature sensor, and the heat source are electrically coupled. It is placed on the temple portion of the aforementioned eyeglasses, The method according to claim 19, wherein the temple portion is configured to receive a power attachment connection.

25. The method according to claim 19, wherein heating the left contour of the nose and the right contour of the nose to the predetermined temperature includes heating the nasal vestibule.

26. The method according to claim 19, wherein heating the left contour of the nose and the right contour of the nose to the predetermined temperature is performed according to a heating cycle selected based at least partially on the indicated pathogen.

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