Silicon phthalocyanine dyes and silicon tribenzophthalocyanine dyes, and their use in diagnosis and therapy
Patent Information
- Authority / Receiving Office
- JP · JP
- Patent Type
- Applications
- Current Assignee / Owner
- ALBERT LUDWIGS UNIV FREIBURG
- Filing Date
- 2024-03-21
- Publication Date
- 2026-06-26
AI Technical Summary
Existing silicon phthalocyanine dyes for photodynamic therapy lack the ability to effectively penetrate deep into tissue and target specific biological structures, limiting their therapeutic efficacy.
Development of novel silicon tribenzophthalocyanine dyes with a 3:1 naphthalocyanine/phthalocyanine hybrid core, covalently bonded to molecules like antibodies, which absorb light in the red to near-infrared region and are water-soluble, allowing deeper tissue penetration and targeted photodynamic therapy.
The new dyes enable deeper tissue penetration and enhanced therapeutic effects by generating singlet oxygen, effectively destroying targeted cells and inducing an immune response, particularly in tumors.
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