Sample low-temperature storage system

Abstract

The present invention discloses a sample cryogenic storage system including an operating cabin and a storage cabin, the operating cabin being positioned above the storage cabin and allowing access to the samples in the storage cabin, the upper end surface of the storage cabin having multiple storage openings, a lift well component being installed inside the operating cabin and movable within the operating cabin, the lift well component moving to each corresponding storage opening and lifting the basket inside the storage cabin. The beneficial effects of the present invention are as follows: the lift well component can lift the basket inside the operating cabin, the shovel plate component can push out the plate frame of the basket, the rotary grip component is 360-degree rotatable and can grip the plate frame or sample, the jack-up mechanism can jack up the intermediate tank and dock it with the operating cabin, and the rotary grip component can store the sample or plate frame in the intermediate tank into the storage cabin by storing it in the basket with the shovel plate component and the lift well component, thereby greatly improving work efficiency.

Description

Technical Field

[0001] The present invention relates to the technical field of sample storage technology, and particularly to a sample low-temperature storage system.

Background Art

[0002] In the biomedical field, sample freezing storage devices are used to store biological samples such as blood samples, vaccines, and bacterial and viral strains at low temperatures, and the samples are left in liquid nitrogen for long-term active storage. A plurality of sample cartridges are stored in the device, and a plurality of test tubes are stored side by side in the sample cartridge, and the samples to be stored are in the test tubes.

[0003] In current freezing storage devices, in the process of extracting biological samples, it is necessary to add a lift shaft mechanism above the storage device to extract its basket from the storage device, and to derive the sample cartridge in the basket by an external fixed shovel plate mechanism. This not only takes up a large amount of space, but the fixed lift shaft mechanism is not convenient. For relatively large storage refrigerators, it is inconvenient to extract the basket, which reduces the working efficiency. Therefore, there is an urgent need for a sample access system.

Summary of the Invention

Problems to be Solved by the Invention

[0004] The purpose of this part is to outline some aspects of the embodiments of the present invention and briefly introduce some preferred embodiments. To avoid ambiguity in the purpose of this part, the abstract of the specification, and the name of the invention, this part, the abstract of the present application, and the name of the invention may be simplified or omitted, but this simplification or omission cannot be used to limit the scope of the present invention.

Means for Solving the Problems

[0005] <了 In view of the above or existing problems in the prior art, the present invention is proposed.

[0006] Therefore, an object of the present invention is to provide a sample cryogenic storage system which moves within a storage cabin by a lift well component, can lift a basket within the storage cabin by raising and lowering the lift well component, can scrape a sample plate frame from the basket by a shovel plate component, can transfer the sample plate frame by a rotary grip component, and the rotary grip component can further pipette the sample on the plate frame, can dock an intermediate tank with the operating cabin by a jack-up mechanism, and the rotary grip component can open the top lid of the intermediate tank and place it to the side, and can open the insulated lid on the storage cabin via a lid opening component.

[0007] To solve the above technical problems, the present invention provides the following technical solution: a sample cryogenic storage system including an operating cabin and a storage cabin, wherein the operating cabin is installed above the storage cabin and allows access to the samples in the storage cabin. Multiple storage openings are provided on the upper surface of the storage cabin. A lift well component is installed inside the operating cabin. The lift well component is movable within the operating cabin and can move to each corresponding storage port to lift the basket inside the storage cabin.

[0008] In a preferred embodiment of the sample cryogenic storage system of the present invention, a rotating gripping component for gripping a biological plate frame or biological sample so as to be able to move up and down and rotate is further installed inside the operating cabin.

[0009] In a preferred embodiment of the sample low-temperature storage system of the present invention, a shovel plate component is installed on the outer circumference of a lift well component, a plate frame storage passage is provided in the lift well component, and the shovel plate component can scrape or store plate frames in a basket via the plate frame storage passage.

[0010] In a preferred embodiment of the sample low-temperature storage system of the present invention, a lid opening component capable of raising and lowering and gripping the insulating lid above the storage opening is further installed inside the operating cabin.

[0011] In a preferred embodiment of the sample cryogenic storage system of the present invention, the lift well component includes a support moving member, a support casing slide member, and a lifting hook acquisition member. The support moving member is slidably connected to the operating cabin, and the support casing sliding member is slidably connected to the support moving member in the vertical or horizontal direction. Inside the support casing sliding member, a lifting hook acquisition member is installed that can lift the basket inside the storage cabin via a storage opening.

[0012] In a preferred embodiment of the sample low-temperature storage system of the present invention, the support casing slide member includes a support casing, a lateral slide frame of the support casing, a vertical slide support frame of the support casing, a vertical guide rail of the support casing, and a vertical slider. The bottom ends of the lateral slide frame of the support casing are laterally slidably connected to the first guide rail and the second guide rail of the support casing, one side of the lateral slide frame of the support casing is connected to the vertical slide support frame of the support casing, the vertical guide rail and the first drive mechanism of the support casing are installed inside the vertical slide support frame of the support casing, a vertical slide groove is provided on the side of the vertical slide support frame of the support casing, the vertical slider is slidably connected to the vertical guide rail of the support casing, the vertical slider is connected to the support casing via a connecting shaft passing through the vertical slide groove, the support casing is installed between the first guide rail and the second guide rail of the support casing, the vertical guide rail shaft is installed on the side of the support casing, the vertical guide rail shaft slider is installed on the side of the vertical slide support frame of the support casing, the vertical guide rail shaft is slidably connected to the vertical guide rail shaft slider.

[0013] In a preferred embodiment of the sample low-temperature storage system of the present invention, the lifting hook acquisition member includes a handle slider, a lift section, a handle slider guide rail, an arch-shaped stopper, and a rotating lift-up member. A handle slider guide rail is installed on the inner wall of the support casing, the handle slider is slide-connected longitudinally to the handle slider guide rail, a lift section is connected to the lower end surface of the handle slider, a second drive mechanism is installed in the support casing, the second drive mechanism is capable of driving a rotating lift-up member to rotate, the rotating lift-up member is connected to the handle slider, the rotating lift-up member can raise and lower the handle slider along the handle slider guide rail, and an arch-shaped stopper is installed on the upper side of the inner wall of the support casing.

[0014] In a preferred embodiment of the sample cryogenic storage system of the present invention, the rotary gripping component includes a rotary clamping member, a pipette gripping member, and a gripping support shaft. Both ends of the gripping support shaft are slidably connected to the inside of the operating cabin, and the pipette gripping members are slidably connected to both sides of the gripping support shaft.

[0015] In a preferred embodiment of the sample low-temperature storage system of the present invention, the rotating clamp member includes a clamp support lateral slide plate, a vertical stroke plate, a rotating shaft drive member, a rotating shaft, a clamp frame, a clamp, and a clamp drive mechanism. The clamp-support lateral slide plate is slidably connected to the side of the gripping support shaft, the vertical stroke plate is slidably connected vertically to the side of the clamp-support lateral slide plate, the lower end of the vertical stroke plate is connected to the rotating shaft drive member, the rotating shaft drive member is connected to one end of the rotating shaft, the other end of the rotating shaft is connected to the clamp frame, and a clamp drive mechanism is installed inside the clamp frame that drives the clamp to grip the biological plate frame.

[0016] In a preferred embodiment of the sample cryogenic storage system of the present invention, the pipette gripping member includes a pipette support shaft, a pipette vertical slide plate, a pipette support block, a pipette, and a liquid nitrogen cylinder. The pipette support shaft is slidably connected to the other side of the gripping support shaft, the pipette longitudinal slide plate is slidably connected longitudinally to the pipette support shaft, the pipette support block is connected to the pipette longitudinal slide plate, the pipette support block is connected to the pipette, a liquid nitrogen cylinder is placed on the outer circumference of the pipette, and the pipette can aspirate from a cryopreservation tube.

[0017] In a preferred embodiment of the sample cryogenic storage system of the present invention, the shovel plate component includes a scraping member and a storage member. The storage member is equipped with a scraping member that can push out biological plate frames from the basket through the plate frame storage passage, and the storage member can push biological plate frames into the basket through the plate frame storage passage.

[0018] In a preferred embodiment of the sample low-temperature storage system of the present invention, the storage member includes a shovel plate, a slide push plate, a push block, a slide push plate support plate, a straight tooth plate, a straight tooth plate meshing gear, a gear drive mechanism, and a support casing. The shovel plate is installed at the lower inner end of the plate frame storage passage and connected to the support casing, the outside of the support casing is connected to the slide push plate support plate, the slide push plate is slidably connected to the slide push plate support plate, the slide push plate is fitted onto the outer circumference of the support casing, the slide push plate is connected to the push block, a straight tooth plate is connected to one side of the slide push plate, the gear drive mechanism is connected to the straight tooth plate meshing gear, the straight tooth plate meshing gear engages with the straight tooth plate, and the slide push plate support plate is connected to the gear drive mechanism.

[0019] In a preferred embodiment of the sample low-temperature storage system of the present invention, the scraping member here includes a push rod, a push rod straight tooth plate, a push rod straight tooth plate support shaft, and a push rod drive mechanism. The pushrod straight tooth plate support shaft is connected to a sliding pushrod plate support plate, the pushrod straight tooth plate support shaft is located at the end away from the push block, the pushrod straight tooth plate is slidably connected to the pushrod straight tooth plate support shaft, the front end of the pushrod straight tooth plate is connected to the pushrod, the upper end of the pushrod straight tooth plate is engaged with the pushrod drive mechanism, and the pushrod straight tooth plate meshing gear can drive the pushrod drive mechanism.

[0020] In a preferred embodiment of the sample cryogenic storage system of the present invention, the lid opening component includes a lid opening support shaft, a drive lifting mechanism, a telescopic rod, a support rod, a hook portion, and a guide rod. The cover opening support shaft is slidably connected inside the operation cabin, the drive lifting mechanism is installed on the cover opening support shaft, the upper end of the telescopic rod is connected to the drive lifting mechanism, the lower end of the telescopic rod is connected to the support rod, both ends of the support rod are connected to the hook portion, and the guide rod is connected to the support rod.

[0021] As a preferred embodiment of the sample low-temperature storage system of the present invention, here, a jacking mechanism for jacking up the relay tank and enabling docking with the operation cabin is further included, and a relay tank access port is opened inside the operation cabin.

[0022] As a preferred embodiment of the sample low-temperature storage system of the present invention, here, the jacking mechanism includes a seventh drive member, a seventh guide rail, a seventh lifting frame, and a serial conveyor belt. The seventh lifting frame is slidably connected vertically to the seventh guide rail, a relay tank can be placed on the upper end surface of the seventh lifting frame, the seventh drive member can drive the seventh lifting frame to move up and down along the seventh guide rail, and the serial conveyor belt is installed on the upper end surface of the seventh guide rail.

[0023] As a preferred embodiment of the sample low-temperature storage system of the present invention, here, the inside of the operation cabin further includes an identification warehousing member and a rotary cleaning member. The identification warehousing member can identify the barcode of the sample or the plate frame, and the rotary cleaning member can clean the sample or the plate frame.

Advantages of the Invention

[0024] The beneficial effects of the present invention are as follows. 1. The present invention can store the samples in the basket by means of a storage cabinet, and a plurality of sets of baskets can be stored in the storage cabinet. 2. The target basket can be lifted by moving up and down inside the operation cabin by means of a lift well component. By installing a movable lift well component, it is made easier to lift the baskets in a large-capacity storage cabinet and a huge amount of space is saved. 3. By lifting and lowering the basket by means of the lift well component, the plate frames or storage slots of each layer of the basket can be respectively positioned at the plate frame storage passage positions. 4. Scraping or storing the plate frames of each layer of the basket can be performed by means of a shovel plate component. 5. By rotating 360 degrees of the rotary gripping component, the biological plate frames on the basket in the operation cabin can be scraped or stored. 6. By rotating the hand on the rotary gripping component, the plate frames or sample tubes in the operation cabin can be gripped, rotationally scanned or cleaned. 7. The heat preservation cover on the storage cabinet can be lifted and moved by means of a cover opening component, and the heat preservation cover can cover the storage opening and keep the storage cabinet warm. 8. The relay tank can be jacked up by means of a jacking mechanism to dock with the operation cabin, and the rotary gripping component can store the samples or plate frames in the relay tank in the storage cabinet by storing them in the basket by means of the shovel plate component and the lift well component, which can greatly improve the working efficiency.

Brief Description of the Drawings

[0025] For the purpose of more clearly explaining the technical solutions of the embodiments of the present invention, the following briefly introduces the attached drawings that need to be used in the description of the embodiments. It is self-evident that the attached drawings in the following description are only some embodiments of the present invention. For those skilled in the art, based on these attached drawings without creative efforts, other attached drawings can also be obtained. Here, [Figure 1]This is a schematic diagram of the sample low-temperature storage system. [Figure 2] This is a schematic diagram of the operating cabin for the sample cryogenic storage system. [Figure 3] This is a cross-section view of the storage cabin of a sample cryogenic storage system. [Figure 4] This is a three-dimensional view of the storage cabin of the sample cryogenic storage system. [Figure 5] This is a schematic diagram of the lid opening component of the sample cryogenic storage system. [Figure 6] This is a schematic diagram of the rotary gripping component and lift well component of the sample cryogenic storage system. [Figure 7] This is a schematic three-dimensional view of the rotating gripping component of the sample cryogenic storage system. [Figure 8] This is a schematic diagram of the support casing slide member of the sample low-temperature storage system. [Figure 9] This is a schematic diagram of the shovel plate component of the sample cryogenic storage system. [Figure 10] This is a local cross-sectional view of the support casing slide member of the sample cryogenic storage system. [Figure 11] This is a schematic diagram of the shovel plate component of the sample cryogenic storage system. [Figure 12] This is a schematic diagram of the lifting hook acquisition component for the sample low-temperature storage system. [Figure 13] This is a close-up view of the lifting hook acquisition component of the sample low-temperature storage system. [Figure 14] This is a schematic diagram of the rotating gripping component of the sample cryogenic storage system. [Figure 15] This is a schematic diagram of the jack-up component of the sample cryogenic storage system. [Figure 16] This is a schematic diagram of the jack-up component of the sample cryogenic storage system. [Figure 17] This is a schematic diagram of the rotating cleaning component of the sample low-temperature storage system. [Modes for carrying out the invention]

[0026] To make the above-mentioned objectives, features, and advantages of the present invention clearer, specific embodiments of the present invention will be described in detail below with reference to the drawings of the specification.

[0027] The following description provides many specific details in order to fully understand the present invention. However, the present invention can also be implemented in ways other than those described herein, and those skilled in the art can implement similar measures without being contrary to the spirit of the invention. Therefore, the present invention is not limited to the specific embodiments disclosed below.

[0028] Next, as used herein, “an embodiment” or “an example” means a specific feature, structure or characteristic that may be included in at least one embodiment of the present invention. Where “in one embodiment” appears differently in this specification, it does not mean that all instances refer to the same embodiment, nor does it mean that an embodiment is mutually exclusive with or independently of other embodiments.

[0029] <Example 1> Referring to Figures 1 to 4, a first embodiment of the present invention is provided, which provides a sample cryogenic storage system including an operating cabin 1 and a storage cabin 2, the storage cabin 2 being able to store multiple sets of baskets, the baskets being able to store multiple sets of biological plate frames, the plate frames being placed on top of biological samples, and the baskets in the storage cabin 2 being lifted into the operating cabin 1 by moving up and down within the operating cabin 1 using a lift well component 3.

[0030] Specifically, it includes an operating cabin 1 and a storage cabin 2, the operating cabin 1 being located above the storage cabin 2 and allowing access to and manipulation of samples within the storage cabin 2. Multiple storage openings are provided on the upper end surface of the storage cabin 2. Inside the operating cabin 1, there is a lift well component 3 that is movable within the operating cabin 1. The lift well component 3 can move to each corresponding storage port and lift the baskets inside the storage cabin 2.

[0031] In summary, the present invention involves storing multiple sets of baskets within the storage cabin 2, allowing multiple sets of biological plate frames to be stored in the baskets, and allowing multiple sets of sample tubes to be placed within the biological plate frames. The lift well component 3 moves up and down within the operating cabin 1 to lift the target basket into the storage cabin 2, and after passing through the access plate frame, it is returned to the storage cabin 2 to achieve freezing. The installation of a movable lift well component 3 facilitates lifting baskets from the large-capacity storage cabin 2 and saves a great deal of space.

[0032] <Example 2> Referring to Figures 1 to 17, a second embodiment of the present invention exists in which, in the first embodiment, the sample cryogenic storage system includes an operating cabin 1 and a storage cabin 2, the storage cabin 2 can accommodate multiple sets of baskets, the baskets can accommodate multiple sets of biological plate frames, the plate frames can be placed on, and the baskets in the storage cabin 2 can be lifted into the operating cabin 1 by moving up and down within the operating cabin 1 using a lift well component 3.

[0033] Specifically, it includes an operating cabin 1 and a storage cabin 2, the operating cabin 1 being located above the storage cabin 2 and allowing access to and manipulation of samples within the storage cabin 2. Multiple storage openings are provided on the upper end surface of the storage cabin 2. Inside the operating cabin 1, there is a lift well component 3 that is movable within the operating cabin 1. The lift well component 3 can move to each corresponding storage port and lift the baskets inside the storage cabin 2.

[0034] Furthermore, a rotating gripping component 4 is installed inside the operating cabin 1 to grip a biological plate frame or biological sample so that it can be raised, lowered, and rotated.

[0035] Preferably, the rotary gripping component 4 can move in the XYZ axis directions within the operating cabin 1, and the rotary clamping member 41 of the rotary gripping component 4 can rotate horizontally at any angle.

[0036] Furthermore, a shovel plate component 5 is installed on the outer perimeter of the lift well component 3, and a plate frame storage passage is provided in the lift well component 3, allowing the shovel plate component 5 to scrape or store plate frames in a basket via the plate frame storage passage.

[0037] Furthermore, a lid opening component 6 capable of raising and lowering the heat-retaining lid above the storage opening is also installed inside the operating cabin 1.

[0038] Preferably, the lid opening component 6 is movable within the operating cabin 1 and can close the insulating lid on the corresponding storage cabin 2, and insulating lids are installed on multiple storage openings, and the lid opening component 6 can open the insulating lids.

[0039] Furthermore, the lift well component 3 includes a support moving member 31, a support casing slide member 32, and a lifting hook acquisition member 33. The support movable member 31 is slidably connected to the operating cabin 1, and the support casing slide member 32 is slidably connected to the support movable member 31 in the vertical or horizontal direction. A lifting hook acquisition member 33 is installed inside the support casing slide member 32, which is capable of lifting the basket inside the storage cabin 2 via a storage opening.

[0040] Preferably, the support moving member 31 is slidably connected along the inner wall of the operating cabin 1, the support casing slide member 32 is capable of moving laterally and vertically along the support moving member 31, and a lifting hook acquisition member 33 is installed inside the support casing slide member 32, which is capable of sliding up and down along the inside of the support casing slide member 32.

[0041] Furthermore, the support casing slide member 32 includes a support casing 3201, a lateral slide frame 3202 of the support casing, a vertical slide support frame 3203 of the support casing, a vertical guide rail 3204 of the support casing, and a vertical slider 3205. The bottom ends of the lateral slide frame 3202 of the support casing are laterally slidably connected to the first guide rail 3101 and the second guide rail 3102 of the support casing, one side of the lateral slide frame 3202 of the support casing is connected to the vertical slide support frame 3203 of the support casing, the vertical guide rail 3204 of the support casing and the first drive mechanism are installed inside the vertical slide support frame 3203 of the support casing, vertical slide grooves are provided on the side of the vertical slide support frame 3203 of the support casing, and the vertical slider 3205 supports The vertical slider 3205 is slidably connected to the vertical guide rail 3204 of the casing, and is connected to the support casing 3201 via a connecting shaft through a vertical slide groove hole. The support casing 3201 is installed between the first guide rail 3101 and the second guide rail 3102 of the support casing. A vertical guide rail shaft is installed on the side of the support casing 3201, and a vertical guide rail shaft slider is installed on the side of the vertical slide support frame 3203 of the support casing. The vertical guide rail shaft is slidably connected to the vertical guide rail shaft slider in the vertical direction.

[0042] Preferably, two sets of support moving members 31 can be provided, guide rails are installed on the support moving members 31, and the support casing slide member 32 is slidable on its upper surface.

[0043] Preferably, the support moving members 31 at the bottom ends on both sides of the lateral slide frame 3202 of the support casing are slidably connected, and the sides of the lateral slide frame 3202 of the support casing are connected to the longitudinal slide support frame 3203 of the support casing.

[0044] Preferably, a first drive mechanism can slide the vertical slider 3205 along the vertical guide rail 3204 of the support casing, and the vertical slider 3205 is fixedly connected to the support casing 3201 by passing through a vertical slide groove hole, and the vertical guide rail axis of the support casing 3201 is connected so as to be able to slide up and down along the vertical guide rail axis slider when raising and lowering.

[0045] Preferably, the rotating shaft drive member 4103, the first drive mechanism, the second drive mechanism, the clamp drive mechanism 4107, the gear drive mechanism 5207, and the push rod drive mechanism 5104 may be motor-driven, air cylinder-driven, or electric cylinder-driven, or they may be hydraulically driven or of other types.

[0046] Furthermore, the lifting hook acquisition member 33 includes a handle slider 3301, a lift section 3302, a handle slider guide rail 3303, an arch-shaped stopper 3305, and a rotating lift-up member 3304. The handle slider guide rail 3303 is installed on the inner wall of the support casing 3201, the handle slider 3301 is slidably connected to the handle slider guide rail 3303 in the vertical direction, the lift section 3302 is connected to the lower end surface of the handle slider 3301, the support casing 3201 is equipped with a second drive mechanism that can drive and rotate the lift-up member 3304 to rotate, the rotating lift-up member 3304 is connected to the handle slider 3301, the rotating lift-up member 3304 can raise and lower the handle slider 3301 along the handle slider guide rail 3303, and the arch-shaped stopper 3305 is installed on the upper side of the inner wall of the support casing 3201.

[0047] Preferably, the rotating lift-up member 3304 includes a rotating belt and a rotating wheel, and the second drive mechanism rotates the rotating wheel, which rotates the rotating belt, and one side of the rotating belt is connected to a handle slider 3301, so that when the rotating belt rotates, the handle slider 3301 can be raised and lowered along the handle slider guide rail 3303.

[0048] The rotating lift-up member 3304 may be provided with a sprocket and chain fitted together, or the rotating lift-up member 3304 may be a lifting mechanism that directly raises and lowers the handle slider 3301.

[0049] Furthermore, the handle slider 3301 may be directly driven by a motor to move up and down along the handle slider guide rail 3303.

[0050] Preferably, the second drive mechanism drives the rotating lift-up member 3304, causing the handle slider 3301 to move up and down along the handle slider guide rail 3303, the handle slider 3301 moves the lift section 3302 up and down, and the lift section 3302 moves the basket up and down by scooping up or gripping the upper end of the basket.

[0051] Furthermore, multiple sets of plate frames may be stored vertically in the basket, and the basket may have multiple storage spaces, each of which can accommodate a plate frame.

[0052] Preferably, the lift section 3302 may be a gripping hand or a hook hand, a visual sensing device may be installed at the upper end inside the support casing 3201, the visual sensing device may be a camera or a sensor that can detect the position the basket has arrived at, and the arch-shaped stopper 3305 has a certain elasticity and can serve to cushion the basket.

[0053] Preferably, the lift section 3302 pulls the basket into the support casing 3201.

[0054] Furthermore, the rotary gripping component 4 includes a rotary clamp member 41, a pipette gripping member 42, and a gripping support shaft 43. Both ends of the gripping support shaft 43 are slidably connected to the inside of the operating cabin 1, and the pipette gripping member 42 and the rotary clamp member 41 are slidably connected to both sides of the gripping support shaft 43, respectively.

[0055] Furthermore, the rotating clamp member 41 includes a clamp support lateral slide plate 4101, a vertical stroke plate 4102, a rotating shaft drive member 4103, a rotating shaft 4104, a clamp frame 4105, a clamp 4106, and a clamp drive mechanism 4107. The clamp support lateral slide plate 4101 is slidably connected to the side of the gripping support shaft 43, the vertical stroke plate 4102 is slidably connected vertically to the side of the clamp support lateral slide plate 4101, the lower end of the vertical stroke plate 4102 is connected to the rotating shaft drive member 4103, the rotating shaft drive member 4103 is connected to one end of the rotating shaft 4104, the other end of the rotating shaft 4104 is connected to the clamp frame 4105, and a clamp drive mechanism 4107 is installed inside the clamp frame 4105 that drives the clamp 4106 to grip the biological plate frame.

[0056] The clamp support lateral slide plate 4101 is slidably connected to the gripping support shaft 43 in the lateral direction, and the vertical stroke plate 4102 is slidably connected to the other side of the clamp support lateral slide plate 4101 by the drive of a motor. The lower end of the vertical stroke plate 4102 is connected to the rotating shaft drive member 4103, which can rotate the rotating shaft 4104, enabling 360-degree rotation. The rotating shaft 4104 can rotate the clamp frame 4105 and the clamp 4106, and the clamp drive mechanism 4107 drives the clamp 4106 to grip the plate frame.

[0057] Furthermore, the pipette gripping member 42 includes a pipette support shaft 4201, a pipette vertical slide plate 4202, a pipette support block 4203, a pipette 4204, and a liquid nitrogen cylinder 4205. The pipette support shaft 4201 is slidably connected to the other side of the gripping support shaft 43, the pipette longitudinal slide plate 4202 is slidably connected longitudinally to the pipette support shaft 4201, the pipette support block 4203 is connected to the pipette longitudinal slide plate 4202, the pipette support block 4203 is connected to the pipette 4204, a liquid nitrogen cylinder 4205 is installed on the outer circumference of the pipette 4204, and the pipette 4204 can aspirate from a cryopreservation tube.

[0058] Furthermore, the pipette support shaft 4201 can be slidably connected along the other side of the gripping support shaft 43, the pipette vertical slide plate 4202 can be slidably connected vertically along the other side of the pipette support shaft 4201, the pipette vertical slide plate 4202 is connected to the pipette support block 4203, the pipette support block 4203 raises and lowers the pipette 4204, a liquid nitrogen cylinder 4205 is installed around the outer circumference of the pipette 4204, liquid nitrogen can be placed inside the liquid nitrogen cylinder 4205, the lower end of the pipette 4204 can aspirate a cryopreservation tube, and a vacuum pump is connected to the pipette to provide positive and negative pressure gas to the pipette 4204, facilitating the aspiration of the cryopreservation tube.

[0059] Furthermore, the shovel plate component 5 includes a scraping member 51 and a storage member 52. The storage member 52 is equipped with a scraping member 51 that can push out biological plate frames in the basket through the plate frame storage passage, and the storage member 52 can push biological plate frames into the basket through the plate frame storage passage.

[0060] Furthermore, the storage member 52 includes a shovel plate 5201, a slide push plate 5202, a push block 5203, a slide push plate support plate 5204, a straight tooth plate 5205, a straight tooth plate meshing gear 5206, a gear drive mechanism 5207, and a support casing 3201. The shovel plate 5201 is installed at the lower inner end of the plate frame storage passage and connected to the support casing 3201, the outside of the support casing 3201 is connected to the slide push plate support plate 5204, the slide push plate 5202 is slidably connected to the slide push plate support plate 5204, the slide push plate 5202 is fitted onto the outer circumference of the support casing 3201, the slide push plate 5202 is connected to the push block 5203, a straight tooth plate 5205 is connected to one side of the slide push plate 5202, the gear drive mechanism 5207 is connected to the straight tooth plate meshing gear 5206, the straight tooth plate meshing gear 5206 engages with the straight tooth plate 5205, and the slide push plate support plate 5204 is connected to the gear drive mechanism 5207.

[0061] Preferably, the rotating clamp member 41 can grip the plate frame onto the shovel plate 5201, then the gear drive mechanism 5207 rotates the straight-tooth plate meshing gear 5206, which meshes with the straight-tooth plate 5205, thereby moving the straight-tooth plate 5205 and the slide push plate 5202, the slide push plate 5202 moves the push block 5203, the push block 5203 moves the plate frame into the basket, and after the storage of the plate frame is complete, the push block 5203 terminates.

[0062] Furthermore, the scraping member 51 includes a push rod 5101, a push rod straight tooth plate 5102, a push rod straight tooth plate support shaft 5103, and a push rod drive mechanism 5104. The push rod straight tooth plate support shaft 5103 is fixedly supported and connected to the slide push plate support plate 5204, and the push rod straight tooth plate support shaft 5103 is installed at the end away from the push block 5203, the push rod straight tooth plate 5102 is slidably connected to the push rod straight tooth plate support shaft 5103, the front end of the push rod straight tooth plate 5102 is connected to the push rod 5101, and the upper end of the push rod straight tooth plate 5102 is engaged with the push rod drive mechanism 5104, and the push rod straight tooth plate meshing gear can drive the push rod drive mechanism 5104.

[0063] The push rod drive mechanism 5104 rotates the push rod gear, which meshes with the push rod straight tooth plate 5102, thereby moving the push rod straight tooth plate 5102. The push rod straight tooth plate 5102 slides along the push rod straight tooth plate support shaft 5103, which moves the push rod straight tooth plate 5102 forward. The push rod 5101 pushes the plate frame in the basket into the basket, dropping the plate frame onto the shovel plate 5201, facilitating gripping or pipetting by the rotary gripping component 4.

[0064] Furthermore, when the basket is inside the support casing 3201, the push rod 5101 can scrape the plate frame through the storage passage, and the push block 5203 can be stored in the plate frame through the storage passage. The lifting hook acquisition member 33 raises and lowers the basket, allowing the plate frame or storage space on the basket to be positioned in the storage passage, thus facilitating access to the baskets in each layer.

[0065] Furthermore, the lid opening component 6 includes a lid opening support shaft 601, a drive lifting mechanism 602, a telescopic rod 603, a support rod 604, a hook portion 605, and a guide rod 606. The lid opening support shaft 601 is slidably connected to the inside of the operating cabin 1, the drive lifting mechanism 602 is installed on the lid opening support shaft 601, the upper end of the telescopic rod 603 is connected to the drive lifting mechanism 602, the lower end of the telescopic rod 603 is connected to the support rod 604, both ends of the support rod 604 are connected to the hook portion 605, and the guide rod 606 is connected to the support rod 604.

[0066] Preferably, the seventh drive member 701 and the drive lifting mechanism 602 may be a motor, an air cylinder, or another drive lifting mechanism. Preferably, the drive lifting mechanism 602 is capable of driving the telescopic rod 603 up and down, the telescopic rod raising and lowering the support rod 604, and hook portions 605 are installed on both sides of the support rod 604, the hook portions 605 can scoop up the insulation lid on the upper end surface of the storage cabin 2, and the insulation lid can close the storage opening.

[0067] Furthermore, it includes a jack-up mechanism 7 that allows the relay tank to be jacked up and docked with the operating cabin 1, and a relay tank passage opening is provided inside the operating cabin 1.

[0068] Preferably, a tank cap storage mechanism is further installed in the operating cabin 1, which is capable of supporting the tank caps of the intermediate tanks and can accommodate tank caps of different sizes.

[0069] Furthermore, the jack-up mechanism 7 includes a seventh drive member 701, a seventh guide rail 702, a seventh lifting frame 703, and a series conveyor belt 704. The seventh lifting frame 703 is slidably connected vertically to the seventh guide rail 702, a relay tank can be placed on the upper end surface of the seventh lifting frame 703, the seventh drive member 701 can drive the seventh lifting frame 703 to move up and down along the seventh guide rail 702, and the series conveyor belt 704 is installed on the upper end surface of the seventh guide rail 702.

[0070] Preferably, the seventh drive member 701 can drive the seventh lifting frame 703 to move vertically up and down along the seventh guide rail 702, a relay tank can be placed on the upper end of the seventh lifting frame 703, and the rotary gripping component 4 can move the passage cover over the relay tank passage opening laterally to facilitate docking the relay tank with the operating cabin 1.

[0071] Preferably, the series conveyor belt 704 can be connected in series to multiple sets of storage equipment, and the relay tank can be transmitted between multiple storage equipment or other equipment by the series conveyor belt 704, greatly saving manpower.

[0072] Furthermore, the operating cabin 1 further includes an identification storage member 8 and a rotating cleaning member 9, the identification storage member 8 being able to identify the barcode on the sample or plate frame, and the rotating cleaning member 9 being able to clean the sample or plate frame.

[0073] Preferably, the identification storage member 8 can scan and identify the labels on the plate frame or sample tubes, and the rotating cleaning member 9 can clean frost from the labels on the plate frame or sample tubes, thus avoiding the phenomenon of being unable to identify them.

[0074] Furthermore, a basket frame capable of supporting the basket is installed inside the storage cabin 2, and the storage cabin 2 is a low-temperature storage facility, ensuring the activity of the samples.

[0075] As described above, the present invention allows the corresponding heat-insulating lid to be opened by the lid opening component 6, the basket in the storage cabin 2 to be grasped or scooped up by the lifting hook acquisition member 33 to lift the basket to the plate frame storage passage position, the scraping member 51 to push out the plate frame in the plate frame storage passage position of the basket, and the rotating gripping component 4 to grasp the pushed-out plate frame and perform the following operations: by raising and lowering the lifting hook acquisition member 33, all the plate frames of each layer of the basket can be positioned in the plate frame storage passage position, the storage member 52 can place the plate frame in the storage slot of the basket, the rotating gripping component 4 can pipette the sample tube on the plate frame, and the rotating clamping member 41 can 36 The device is rotatable to 0 degrees, and by opening the top lid of the plate frame or intermediate tank, the rotating clamp member 41 can be prevented from contacting the plate frame or top lid. The intermediate tank can be jacked up by the jack-up mechanism 7 and docked with the operating cabin 1. The rotating grip component 4 can open the top lid of the intermediate tank, and the frozen storage tube or plate frame can be stored in a basket by the shovel plate component 5 and the lift well component 3, allowing the sample to be placed in the storage cabin 2 for freezing. The frozen storage tube and plate frame are scanned by the identification storage member 8 in both the inbound and outbound processes, and frost on the label of the plate frame or frozen storage tube can be cleaned before scanning to prevent situations where scanning is not possible. This device enables automated operation and significantly improves work efficiency.

[0076] Importantly, it should be noted that the structures and arrangements shown in the multiple different exemplary embodiments of this application are illustrative only. While this disclosure describes in detail only a few embodiments, those skilled in the art will readily understand that many modifications are possible (e.g., changes in the dimensions, scale, structure, shape and proportions of various elements, and parameter values ​​(e.g., temperature, pressure, etc.), mounting arrangement, use of materials, color, orientation, etc.) without substantially departing from the novel teachings and merits of the subject matter described in the claims. For example, elements shown as integrally formed may consist of multiple parts or elements, the positions of elements may be reversed or otherwise modified, and the properties, number or position of separate elements may be changed or altered. Thus, all such modifications are intended to fall within the scope of the invention. The order or sequence of any process or method steps may be changed or reordered according to alternative embodiments.

[0077] In the claims, the “apparatus plus function” clause is intended to cover structures for performing the functions described herein, and is intended not only to be equivalent but also equivalent in structure. In the design, operating state and arrangement of exemplary embodiments, other substitutions, modifications, alterations and omissions may be made without departing from the scope of the invention. Thus, the invention is not limited to any particular embodiment but extends to many variations within the scope of the appended claims.

[0078] In order to provide a concise description of exemplary embodiments, it is not necessary to describe all features of actual embodiments (i.e., features that are not relevant to the best mode currently being considered for carrying out the present invention, or features that are not relevant to realizing the present invention).

[0079] It should be understood that in the development process of actual embodiments, many specific embodiment decisions can be made, such as in engineering and design projects. While such development efforts may be complex and time-consuming, for those skilled in the art who benefit from this disclosure, extensive experimentation is unnecessary. Such development efforts become the normal work of design, manufacturing, and production.

[0080] The above embodiments are for illustrative purposes only, and the present invention has been described in detail with reference to preferred embodiments. However, those skilled in the art will understand that the technical aspects of the present invention can be modified or replaced with equivalents without departing from the technical spirit and scope of the present invention, and that these modifications are included within the scope of the claims of the present invention. [Explanation of symbols]

[0081] 1. Operation cabin 2. Storage cabin 3. Lift well components 4 Rotation gripping components 5 Shovel Plate Components 6. Lid opening component 31 Support and moving member 32 Support casing slide member 33 Lifting hook acquisition component 3201 Support casing 3202 Lateral sliding frame of support casing 3203 Support casing vertical sliding support frame 3204 Support casing vertical guide rail 3205 Vertical Slider 3301 Handle Slider 3302 Lift section 3303 Handle Slider Guide Rail 3305 Arch-shaped stopper 3304 Rotating Lift-Up Member 41 Rotating clamp member 42 Pipette gripping member 43 Gripping support shaft 4101 Clamp-supported lateral sliding plate 4102 Vertical Stroke Plate 4103 Rotating shaft drive member 4104 Rotating shaft 4105 Clamp Frame 4106 Clamp 4107 Clamp drive mechanism 4201 Pipette support shaft 4202 Pipette vertical slide plate 4203 Pipette support block 4204 Pipette 4205 Liquid Nitrogen Cylinder 51 Scraping Member 52 Storage components 5201 Shovel Plate 5202 Slide push plate 5203 Push Block 5204 Slide push plate support plate 5205 Straight tooth plate 5206 Straight Tooth Plate Mating Gear 5207 Gear drive mechanism 5101 Pushrod 5102 Push rod straight tooth plate 5103 Push rod straight tooth plate support shaft 5104 Pushrod Drive Mechanism 601 Lid opening support shaft 602 Drive Lifting Mechanism 603 Telescopic Rod 604 Support Rod 605 Hook part 606 Guide Rod 7. Jack-up mechanism 701 Seventh drive member 702 Seventh Guide Rail 703 Seventh Lifting Frame 704 Series conveyor belt 8. Identification and storage member 9 Rotating cleaning member

Claims

1. A sample cryogenic storage system comprising an operating cabin and a storage cabin, wherein the operating cabin is located above the storage cabin and allows access to the samples in the storage cabin. Multiple storage openings are provided on the upper end surface of the storage cabin. A sample cryogenic storage system characterized in that a lift well component is installed inside the operating cabin, the lift well component is movable within the operating cabin, and the lift well component can move to each corresponding storage port and lift baskets inside the storage cabin.

2. The sample cryogenic storage system according to claim 1, further comprising a rotating gripping component for gripping a biological plate frame or biological sample so as to be able to move up and down and rotate within the operating cabin.

3. The sample low-temperature storage system according to claim 2, characterized in that a shovel plate component is installed on the outer circumference of the lift well component, a plate frame storage passage is provided in the lift well component, and the shovel plate component can scrape or store plate frames in a basket via the plate frame storage passage.

4. The sample low-temperature storage system according to claim 1, further comprising a lid opening component capable of raising and lowering and gripping the insulating lid above the storage opening, installed inside the operating cabin.

5. The lift well component includes a support moving member, a support casing slide member, and a lifting hook acquisition member. The sample low-temperature storage system according to any one of claims 1 to 4, characterized in that the support moving member is slidably connected to the operating cabin, the support casing slide member is slidably connected to the support moving member in the vertical or horizontal direction, and a lifting hook acquisition member capable of lifting a basket in the storage cabin via a storage opening is installed inside the support casing slide member.

6. The support casing slide member includes a support casing, a lateral slide frame of the support casing, a vertical slide support frame of the support casing, a vertical guide rail of the support casing, and a vertical slider. The sample low-temperature storage system according to claim 5, characterized in that the bottom ends of both ends of the lateral slide frame of the support casing are slidably connected to a support moving member in the lateral direction, one side of the lateral slide frame of the support casing is connected to the vertical slide support frame of the support casing, a vertical guide rail of the support casing and a first drive mechanism are installed inside the vertical slide support frame of the support casing, a vertical slide groove hole is provided on the side surface of the vertical slide support frame of the support casing which is slidably connected to the vertical guide rail of the support casing, the vertical slider is connected to the support casing via a connecting shaft passing through the vertical slide groove hole, the support casing is installed between a first guide rail of the support case and a second guide rail of the support case, a vertical guide rail shaft is installed on the side surface of the support casing, a vertical guide rail shaft slider is installed on the side surface of the vertical slide support frame of the support casing, and the vertical guide rail shaft is slidably connected in the lateral direction to the vertical guide rail shaft slider.

7. The aforementioned lifting hook acquisition member includes a handle slider, a lift section, a handle slider guide rail, an arch-shaped stopper, and a rotating lift-up member. The sample low-temperature storage system according to claim 6, characterized in that the handle slider guide rail is installed on the inner wall of the support casing, the handle slider is slidably connected to the handle slider guide rail in the vertical direction, the lower end surface of the handle slider is connected to the lift section, the support casing is provided with a second drive mechanism capable of driving a rotating lift-up member to rotate, the rotating lift-up member is connected to the handle slider, the rotating lift-up member can raise and lower the handle slider along the handle slider guide rail, and the arch-shaped stopper is installed on the upper side of the inner wall of the support casing.

8. The rotary gripping component includes a rotary clamping member, a pipette gripping member, and a gripping support shaft. The sample low-temperature storage system according to claim 2, characterized in that both ends of the gripping support shaft are slidably connected to the inside of the operating cabin, and the pipette gripping member and the rotary clamp member are slidably connected to both sides of the gripping support shaft, respectively.

9. The aforementioned rotating clamp member includes a clamp support lateral slide plate, a vertical stroke plate, a rotating shaft drive member, a rotating shaft, a clamp frame, a clamp, and a clamp drive mechanism. The sample low-temperature storage system according to claim 8, characterized in that the clamp support lateral slide plate is slidably connected to the side surface of the gripping support shaft, the vertical stroke plate is slidably connected in the vertical direction to the side surface of the clamp support lateral slide plate, the lower end of the vertical stroke plate is connected to the rotating shaft drive member, the rotating shaft drive member is connected to one end of the rotating shaft, the other end of the rotating shaft is connected to the clamp frame, and a clamp drive mechanism is installed inside the clamp frame that drives the clamp to grip the biological plate frame.

10. The pipette gripping member includes a pipette support shaft, a pipette vertical slide plate, a pipette support block, a pipette, and a liquid nitrogen cylinder. The sample cryogenic storage system according to claim 8, characterized in that the pipette support shaft is slidably connected to the other side of the gripping support shaft, the pipette longitudinal slide plate is slidably connected longitudinally to the pipette support shaft, the pipette support block is connected to the pipette longitudinal slide plate, the pipette support block is connected to the pipette, a liquid nitrogen cylinder is installed on the outer circumference of the pipette, and the pipette can aspirate a cryogenic storage tube.

11. The shovel plate component includes a scraping member and a storage member, The sample low-temperature storage system according to claim 3, characterized in that the storage member is equipped with a scraping member that can push out biological plate frames in the basket through a plate frame storage passage, and the storage member can push biological plate frames into the basket through the plate frame storage passage.

12. The storage member includes a shovel plate, a slide push plate, a push block, a slide push plate support plate, a straight tooth plate, a straight tooth plate meshing gear, a gear drive mechanism, and a support casing. The sample low-temperature storage system according to claim 11, characterized in that the shovel plate is installed at the lower end inside the plate frame storage passage and connected to the support casing, the outside of the support casing is connected to the slide push plate support plate, the slide push plate is slidably connected to the slide push plate support plate, the slide push plate is fitted onto the outer circumference of the support casing, the slide push plate is connected to the push block, a straight tooth plate is connected to one side of the slide push plate, the gear drive mechanism is connected to the straight tooth plate meshing gear, the straight tooth plate meshing gear engages with the straight tooth plate, and the slide push plate support plate is connected to the gear drive mechanism.

13. The scraping member includes a push rod, a push rod straight tooth plate, a push rod straight tooth plate support shaft, and a push rod drive mechanism. The sample low-temperature storage system according to claim 12, characterized in that the push rod straight tooth plate support shaft is connected to the slide push plate support plate, the push rod straight tooth plate support shaft is installed at the end away from the push block, the push rod straight tooth plate is slidably connected to the push rod straight tooth plate support shaft, the front end of the push rod straight tooth plate is connected to the push rod, the upper end of the push rod straight tooth plate is engaged with the push rod drive mechanism, and the push rod straight tooth plate meshing gear can drive the push rod drive mechanism.

14. The aforementioned lid opening component includes a lid opening support shaft, a drive lifting mechanism, a telescopic rod, a support rod, a hook portion, and a guide rod. The sample low-temperature storage system according to claim 4, characterized in that the lid opening support shaft is slidably connected to the inside of the operating cabin, the drive lifting mechanism is installed on the lid opening support shaft, the upper end of the telescopic rod is connected to the drive lifting mechanism, the lower end of the telescopic rod is connected to the support rod, both ends of the support rod are connected to the hook portion, and the guide rod is connected to the support rod.

15. The sample low-temperature storage system according to claim 1, further comprising a jacking mechanism that allows the intermediate tank to be jacked up and docked with the operating cabin, wherein an intermediate tank passage opening is provided inside the operating cabin.

16. The jack-up mechanism includes a seventh drive member, a seventh guide rail, a seventh lifting frame, and a series conveyor belt. The sample low-temperature storage system according to claim 15, characterized in that the seventh lifting frame is slidably connected in the vertical direction to the seventh guide rail, a relay tank can be placed on the upper end surface of the seventh lifting frame, the seventh drive member can drive the seventh lifting frame to move up and down along the seventh guide rail, and the series conveyor belt is installed on the upper end surface of the seventh guide rail.

17. The sample low-temperature storage system according to claim 1, wherein the operating cabin further includes an identification storage member and a rotating cleaning member, the identification storage member being able to identify a barcode on a sample or plate frame, and the rotating cleaning member being able to clean a sample or plate frame.

Images