Active ingredient transport tool

Abstract

To provide an active ingredient delivery tool that provides a complex formulation capable of improving vascular endothelial function, vascular inflammation, arteriosclerosis, and vascular calcification. [Solution] The active ingredient delivery tool (100) includes a rectangular box-shaped adsorption structure (110), an oval or circular Bacillus subtilis structure (120), an oval or circular active ingredient structure (130), and an oval or circular edible gel structure (140). The material of the adsorption structure is non-nanoscale montmorillonite. The Bacillus subtilis structure covers the outside of the adsorption structure. The active ingredient structure covers the outside of the Bacillus subtilis structure. The edible gel structure covers the outside of the active ingredient structure. The edible gel structure provides stability, viscosity, and encapsulation functions to the active ingredient delivery tool, and is a complex formulation that can improve vascular endothelial function, vascular inflammation, arteriosclerosis, and vascular calcification.

Description

[Technical Field]

[0001] The present invention relates to a delivery tool, and more particularly to an active ingredient delivery tool. [Background technology]

[0002] Drug carriers / encapsulation platforms play an important role in drug delivery and modern medicine. These systems are widely applicable in areas such as cancer treatment, infection control, gene therapy, and vaccine delivery. However, many challenges remain to be overcome in terms of biosafety, targeting, manufacturing process, cost, and regulations. Common issues include poor sustained-release of the active ingredient layer and rapid material degradation, which can lead to premature drug release, loss of sustained-release effect, and reduced therapeutic efficacy. Summary of the Invention [Problem to be solved by the invention]

[0003] An embodiment of the present invention provides an active ingredient delivery tool that provides a complex formulation that can improve vascular endothelial function, vascular inflammation, arteriosclerosis, and vascular calcification. [Means for solving the problem]

[0004] One embodiment of the present invention provides an active ingredient delivery tool including an adsorption structure, a Bacillus subtilis structure, an active ingredient structure, and an edible gel structure. The material of the adsorption structure is non-nanoscale montmorillonite. The Bacillus subtilis structure coats the outside of the adsorption structure. The active ingredient structure coats the outside of the Bacillus subtilis structure. The edible gel structure coats the outside of the active ingredient structure.

[0005] In one embodiment, the Bacillus subtilis structure is a unicellular structure.

[0006] In one embodiment, the active ingredient structure is a multicellular structure.

[0007] In one embodiment, the material of the active ingredient structure is any one or a combination of two or more of Astragalus extract, MK-7, L-arginine, and bee venom peptide.

[0008] In one embodiment, the edible gel structure is a polymeric material.

[0009] In one embodiment, the edible gel structure material is any one or a combination of two or more of konjac gel, gelatin, agar, or carrageenan. [Effects of the Invention]

[0010] Based on the above, the edible gel structure of the present invention is a complex formulation that can provide stability, viscosity, and encapsulation functions to active ingredient delivery tools, and can be used as a carrier and texture adjuster for foods, supplements, and medicines, and can improve vascular endothelial function, vascular inflammation, arteriosclerosis, and vascular calcification.

[0011] Furthermore, in this invention, the active ingredient structure is covered on the outside with an edible gel structure, and the large molecular edible gel structure protects the active ingredient structure, thereby maintaining and further enhancing the slow release effect of the active ingredient structure.

[0012] In addition, the present invention uses non-nanoscale montmorillonite as an adsorption structure, which maintains good adsorption and swelling properties, and can be used as a drug carrier, sustained-release material, or food additive.

[0013] In addition, this invention combines the Bacillus subtilis structure with non-nanoscale montmorillonite, which allows it to remain in the human intestines for a long period of time, promote good bacteria, suppress bad bacteria, is resistant to degradation, and is highly efficient, contributing to improving the human immune system and intestinal defecation.

[0014] Furthermore, in this invention, according to the actual problem to be solved, the active ingredient structure of the appropriate material can be combined with non-nano-sized montmorillonite to introduce the medicinal effect of the active ingredient structure and achieve better therapeutic effect. [Brief explanation of the drawings]

[0015] [Figure 1] 1 is an explanatory diagram of an embodiment of an active ingredient delivery tool according to the present invention; DETAILED DESCRIPTION OF THE INVENTION

[0016] To make the present invention easier to understand, the following embodiments are given in detail in conjunction with the drawings.

[0017] The present invention will be described in detail below with reference to the accompanying drawings, but the embodiments provided do not limit the scope of the present invention. The drawings are for illustrative purposes only and are not drawn to scale. For ease of understanding, the same elements will be labeled with the same reference numerals in the following description.

[0018] In the description of each embodiment, the term "active ingredient delivery tool" refers to a structure for encapsulating, carrying, or delivering an active ingredient (such as a drug, plant extract, nutrient, or active molecule), with the purpose of improving stability, absorption rate, bioavailability, site-specific delivery, or controlled release, so as to enable it to act more effectively inside or outside the body.

[0019] FIG. 1 is an explanatory diagram of one embodiment of an active ingredient delivery tool according to the present invention. Referring to FIG. 1, the structure of the active ingredient delivery tool 100 of the present invention is composed of powder granules. The active ingredient delivery tool 100 includes an adsorption structure 110, a Bacillus subtilis structure 120, an active ingredient structure 130, and an edible gel structure 140. The adsorption structure 110, the Bacillus subtilis structure 120, the active ingredient structure 130, and the edible gel structure 140 are also referred to as an adsorption layer, a Bacillus subtilis layer, an active ingredient layer, and an edible gel layer, respectively. The shape of the adsorption structure 110 is, for example, rectangular, and the shapes of the Bacillus subtilis structure 120, the active ingredient structure 130, and the edible gel structure 140 are, for example, oval or circular. The Bacillus subtilis structure 120 covers the outside of the adsorption structure 110. The active ingredient structure 130 coats the outside of the Bacillus subtilis structure 120 , and the edible gel structure 140 coats the outside of the active ingredient structure 130 .

[0020] The adsorption structure 110 is the innermost layer structure (also referred to as the first layer) of the active ingredient delivery tool 100. The adsorption structure 110 refers to a microscale or nanoscale structural design for adsorbing specific molecules, ions, or particles on a material surface or interface. The material of the adsorption structure 110 is non-nanoscale montmorillonite, which is also referred to as normal particle size montmorillonite or large size montmorillonite, and the two layers of the outer Bacillus subtilis structure 120 and the active ingredient structure 130 can be adsorbed after fermentation.

[0021] Non-nanoscale montmorillonite refers to natural or modified montmorillonite clay materials with particle sizes larger than the nanoscale (usually >100 nanometers). When non-nanoscale montmorillonite is used as the adsorption structure 110, its layered structure still has excellent adsorption and swelling properties, and can be used as a pharmaceutical carrier, sustained-release material, or food additive.

[0022] The Bacillus subtilis structure 120 is the first intermediate layer (or second layer) of the active ingredient delivery tool 100. The Bacillus subtilis structure 120 refers to the morphological and cellular structural characteristics of Bacillus subtilis, which is adsorbed to the adsorption structure 110 through fermentation. The Bacillus subtilis structure 120 is a unicellular structure. Because the Bacillus subtilis structure 120 is a probiotic, it first covers the outside of the adsorption structure 110. The unicellular structure refers to the basic structural form in which an organism is composed of only one cell. This cell simultaneously performs all vital functions, including metabolism, proliferation, response to external stimuli, and transmission of genetic information. These structural characteristics give the Bacillus subtilis structure 120 excellent survival and application potential. It can inhabit the human intestine for a long time, induce beneficial bacteria, inhibit harmful bacteria, and resist decay, achieving higher efficiency and improving the immune system and intestinal defecation.

[0023] The active ingredient structure 130 is a second intermediate layer structure (also referred to as the third layer) of the active ingredient delivery tool 100. The active ingredient structure 130 is a multi-molecular structure, and its particle size is larger than that of the single-cell structure of the Bacillus subtilis structure 120. Therefore, the active ingredient structure 130 is arranged in the outermost layer structure of the active ingredient delivery tool 100, and the medicinal ingredients of the active ingredient structure 130 are introduced therein. A multi-molecular structure refers to an ordered or functional combination structure composed of multiple molecules, and these molecules can form a stable complex or layered arrangement through physical adsorption, chemical bonding, or non-covalent bonding forces.

[0024] In one embodiment, the material of the active ingredient structure 130 is selected from any one or a combination of two or more of Astragalus Extract, MK-7 (Menaquinone-7), L-Arginine, and Bee Venom Peptides, so that the active ingredient structure 130 is a molecule or chemical structure of an active substance that exerts a function or effect in the active ingredient delivery tool 100. The material of the active ingredient structure 130 can be applied to carriers and texture control in foods, supplements, and pharmaceuticals, and is a complex formulation that can improve vascular endothelial function, vascular inflammation, arteriosclerosis, and vascular calcification.

[0025] In one embodiment, the Astragalus extract is a concentrated component obtained by water extraction, alcohol extraction, or other extraction methods from the roots of the traditional Chinese medicine Astragalus membranaceus, and contains a variety of active ingredients, such as astragalosides, flavonoids, and polysaccharides. The efficacy of using the Astragalus extract as a material for the active ingredient structure 130 lies in its multiple health benefits, such as immune enhancement, antioxidant, anti-inflammatory, and liver protection.

[0026] In one embodiment, MK-7 is a form of vitamin K2 and belongs to the seventh type of "menaquinones," which has a long-chain side chain structure, a long half-life in the human body, stable activity, and high absorption rate. The efficacy of using MK-7 as a material for active ingredient structure 130 lies in promoting skeletal health, maintaining cardiovascular health, and delaying aging and inflammation.

[0027] In one embodiment, L-arginine is a semi-essential amino acid and, as a precursor of nitric oxide (NO), is involved in various physiological functions, including vasodilation, immunomodulation, insulin secretion, and wound repair. The efficacy of using L-arginine as a material for the active ingredient structure 130 lies in promoting vasodilation and circulation, accelerating wound healing, and immunomodulation.

[0028] In one embodiment, bee venom peptides (also known as bee venom peptides) are various short-chain proteins (peptides) extracted from bee venom, which have biological activity and mainly include melittin, phospholipase A2 (PLA2), apamin, mast cell-degranulating peptide (MCD peptide), etc. The efficacy of using bee venom peptides as a material for the active ingredient structure 130 lies in their various effects, such as anti-inflammatory, antibacterial, analgesic, and collagen protein production promotion.

[0029] The molecules of the edible gel structure 140 are usually very large, i.e., the edible gel structure 140 has a large molecular structure, and the edible gel structure 140 belongs to the macromolecular compounds (macromolecules) and is also called a polymer. The polymer chain structure of the edible gel structure 140 provides viscosity, stability, and gelation effects, making it suitable for use in pharmaceuticals or foods. The edible gel structure 140 covers the three-layer structure consisting of the adsorption structure 110, the Bacillus subtilis structure 120, and the active ingredient structure 130, with the active ingredient structure 130 forming the outermost layer (or fourth layer) of the active ingredient delivery tool 100. The edible gel structure 140 is edible and highly safe, and can be designed into various forms, such as liquid, gel, capsule, and film, depending on different requirements.

[0030] In one embodiment, the material of the edible gel structure is selected from any one or a combination of two or more of konjac gel, gelatin, agar, and carrageenan.

[0031] In one embodiment, konjac gel (also known as konjac gum or konjac polysaccharide gel) is a natural edible gel formed after hydration and gelation of glucomannan extracted from the konjac plant. The benefits of using konjac gel as a material for the edible gel structure 140 include its strong water-absorbing and swelling properties, high water retention, stable gel formation, low calorie content, edibility, and high dietary fiber content, making it suitable for use as a supplement carrier.

[0032] In one embodiment, gelatin (also known as animal gel or collagen protein hydrolysate) is a natural polymeric protein obtained by hydrolyzing collagen protein in animal tissues. The benefits of using gelatin as a material for the edible gel structure 140 are that it has excellent gel-forming ability and edibility, and can be used in pharmaceutical capsules and dietary supplements to coat the outer layers of soft capsules, hard capsules, and tablets.

[0033] In one embodiment, carrageenan (also known as carrageenan or carrageenan) is a natural polysaccharide extracted from red algae and is used as a thickening, gelling, or stabilizing agent. The benefits of using carrageenan as a material for the edible gel structure 140 are that it has excellent gelling and thickening properties, functions as the outermost coating of the active ingredient delivery tool 100, and has good stability at high temperatures and in acidic environments, which helps stabilize and release the active ingredient structure 130.

[0034] In one embodiment, agar is a natural polysaccharide substance extracted from red algae called agar-agar (scientific name: Gracilaria or Gelidium), which has excellent gelling and thickening properties. It dissolves quickly in water and forms a firm gel structure. The benefits of using agar as a material for the edible gel structure 140 lie in its excellent heat resistance, remaining stable at relatively high temperatures, and its good adaptability to acidic environments.

[0035] As described above, the edible gel structure of the present invention can provide stability, viscosity and encapsulation functions to active ingredient delivery tools, and can be used as a carrier and texture control in foods, supplements and medicines, and is a complex formulation that improves vascular endothelial function, vascular inflammation, arteriosclerosis and vascular calcification.

[0036] Furthermore, the present invention uses an edible gel structure to cover the active ingredient structure, and the large molecular edible gel structure protects the active ingredient structure, so that the active ingredient structure still has a sustained release effect, resulting in better efficacy.

[0037] In addition, the present invention uses non-nanoscale montmorillonite as the adsorption structure, which still has good adsorption and swelling properties and can be used as a pharmaceutical carrier, sustained-release material or food additive.

[0038] Furthermore, this invention adopts the structure of Bacillus subtilis and blends non-nanoscale montmorillonite, which can penetrate into the human intestines for a long time, induce good bacteria, inhibit bad bacteria, and is not easily decayed, achieving higher efficiency and improving the human immune system and intestinal defecation.

[0039] Furthermore, based on the actual problem to be solved, the present invention combines the active ingredient structure of an appropriate material with non-nanoscale montmorillonite, and introduces the medicinal properties of the active ingredient structure to achieve better therapeutic effects.

[0040] Although the present invention has been described using the above-mentioned embodiments, it is not limited thereto, and those skilled in the art can make various modifications and improvements without departing from the spirit and scope of the present invention. Therefore, the scope of protection of the present invention is defined by the scope of the attached utility model claims. [Explanation of symbols]

[0041] 100 Active Ingredient Transport Tools 110 Adsorption structure 120 Bacillus subtilis structure 130 Active ingredient structure 140 Edible Gel Structure

Claims

1. an adsorption structure in which the material is non-nanoscale montmorillonite; a Bacillus subtilis structure covering the outside of the adsorption structure; an active ingredient structure that coats the outside of the Bacillus subtilis structure; an edible gel structure that covers the outside of the active ingredient structure; Active ingredient delivery tools, including:

2. The active ingredient delivery tool according to claim 1 , wherein the Bacillus subtilis structure is a unicellular structure.

3. The active ingredient delivery tool according to claim 1 , wherein the active ingredient structure is a multicellular structure.

4. 2. The active ingredient delivery tool according to claim 1, wherein the material of the active ingredient structure is any one or a combination of two or more of Astragalus extract, MK-7, L-arginine, and bee venom peptide.

5. 2. The active ingredient delivery tool according to claim 1, wherein the edible gel structure is a polymer material.

6. 2. The active ingredient delivery tool according to claim 1, wherein the material of the edible gel structure is any one or a combination of two or more of konjac gel, gelatin, agar, and carrageenan.

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