Sweep ultrasonic scanning virus inactivation device

Abstract

To provide a safe physical treatment device in which a virus infected to a human or the internal virus is inactivated (destructed) by applying ultrasonic vibration from a patient's body surface toward a body without using biochemical medicament therapy.SOLUTION: A virus is considered to be a solid particle. A natural frequency (called a resonance frequency or the natural frequency) carried by each solid is found by the expression of Minnaert. The ultrasound for oscillating the natural frequency is applied into the body and the virus is made to have resonant oscillation, and thereby the infected virus is inactivated (destructed). However, all of the virus size are not uniform, and the natural frequency found from the size may not become uniform. Accordingly, the applied ultrasonic frequency is made to sweep (sweep over), and the body surface of the infected patient is scanned by a system shown in Fig. 1, and thereby the infected virus is inactivated (destructed).SELECTED DRAWING: Figure 1

Description

[Technical field]

[0001] The present invention detects viruses that have infected humans by scanning the surface of the infected patient's body with a sweep ultrasonic oscillator scanner. Functional Inactivation ( Structurally It is a device that destroys [Background technology]

[0002] The definition of an organism is that its basic structure is a cell and it is capable of self-replication (Non-Patent Document 1).

[0003] The basic structure of a virus is composed of nucleic acid (RNA or DNA) and a protein shell (capsid) that encases it. Some types are further surrounded by a membrane (envelope) made of lipids and proteins, and there are also viruses (such as coronaviruses) that have glycoprotein spikes on the surface of the envelope.

[0004] Viruses are solid particles that are much smaller than cells. In order for viruses to grow, they have no choice but to infect the cells of other organisms and replicate their nucleic acids (the main body of replication information). Therefore, viruses, which do not form cells and cannot replicate themselves, are not considered living organisms.

[0005] Current treatments for viral infections generally involve preventive vaccination and administration of antiviral drugs after infection, but these can be considered biochemical treatment strategies that treat viruses as living or quasi-living things.

[0006] However, because the patient (host) that the virus infects and attempts to replicate is also a living organism, biochemical strategies often have side effects that harm the host as well, and because viruses undergo repeated mutations each time they replicate, biochemically developed vaccines and antiviral drugs are often ineffective.

[0007] As described above, the present invention regards viruses as non-living solid particles and seeks strategies other than biochemical inactivation.

[0008] Now, every solid object has a natural vibration (also called resonant vibration or resonance). Natural vibration is the vibration at which the object is most likely to vibrate, and the frequency at which this occurs is called the natural frequency (resonant frequency, natural frequency). Also called ) It is known that when vibrations that match this natural frequency are applied to an object, the object vibrates at a larger amplitude (resonant vibration) than the given vibration, causing it to be destroyed or broken. A famous example of destruction caused by natural vibration (resonant vibration) is the experiment in which a wine glass is broken by a human voice. This was done by emitting a sound with a frequency that matches the natural frequency of the wine glass in front of the glass. voice By doing this, the wine glass can be made to resonate and break (destroy) it.

[0009] The size of viruses varies depending on the type, but generally ranges from tens to hundreds of nm, which is about 1 / 100 to 1 / 1000 the size of a biological cell (thousands to tens of thousands of nm) (Non-Patent Document 2). The sizes and characteristics of major viruses are shown in Figure 2 (Non-Patent Document 3).

[0010] Figure 3 shows an electron microscope photograph of SARS-CоV-2 (new coronavirus) (Non-Patent Document 4), and Figure 4 shows the structure of SARS-CоV-2 (new coronavirus) (Non-Patent Document 5).

[0011] The approximate size and shape of the virus can be seen in Figures 2, 3, and 4. In order to calculate the natural frequency (resonant frequency) of the virus as a solid particle, the Minnaert formula (Non-Patent Document 6) was used to calculate the natural frequency (resonant frequency), as shown in Figure 5. resonance The frequency was obtained.

[0012] As shown in Figure 2, for example, the size of the coronavirus is 80 to 120 nm in diameter, and the characteristic frequency (resonant frequency) of a solid particle of this size is , from Minnaert's formula The frequency range is 82 to 55 MHz (see Figure 5).

[0013] However, this calculation result is merely an ideal value, and since viruses are not uniform in size and their internal structures are not uniform, it must be regarded as a strategic approximation.

[0014] The appearance and usage of the device of the present invention are similar to existing ultrasonic diagnostic devices (Patent Document 1).

[0015] The difference between the present invention and an ultrasound diagnostic device is the following two points: (a) The probe of an ultrasound diagnostic device emits ultrasound signals from the surface of the body into the body. Shake The device is equipped with a transmitter / receiver and an image monitor to image the reflected waves (echoes) from inside the body. On the other hand, the scanner of the present invention (corresponding to the probe of an ultrasound diagnostic device) is Infected patients body From the surface Only a transmitter that transmits ultrasonic vibrations is required; no receiver or monitor is required. (b) The purpose of the ultrasound diagnostic device is to visualize information inside the body. Shake The frequency of the ultrasound is 2 to 10 MHz, and the frequency to be selected is determined by the resolution (image quality) and the depth of the ultrasound (depth from the body surface of the target organ). Shake The frequency is selected to be between 50 and 100 MHz in order to match the inherent vibration frequency of the virus obtained from the Minnaert formula. [Prior art documents] [Patent documents]

[0016] [Patent Document 1] Patent Publication No. 53-142072 [Patent Document 2] Real whole Showa 47-024042 [Non-patent literature]

[0017] [Non-Patent Document 1] A biology professional explains what a virus is: the difference between living organisms and the proliferation mechanism of coronaviruses. Chitose Group Homepage<URL: https: / / modia.chitose-bio.com / articles / virus_01 / > [Non-Patent Document 2] "The difference between viruses, bacteria, and fungi" - something you may be too embarrassed to ask about now. Kinki University Hospital Homepage<URL:https: / / www.med.kindai.ac.jp / transfusion / ketsuekigakuwomanabou-252.pdf> [Non-Patent Document 3] General characteristics of viruses. Saga University School of Medicine, Department of Etiology and Pathology, Division of Biodefense Homepage.<URL: http: / / www.microbio.med.saga-u.ac.jp / Lecture / kohashi-inf1 / part8 / 1.html> [Non-Patent Document 4] Electron microscope image of 2019-nCоV. National Institute of Infectious Diseases website<URL:https: / / www.niid.go.jp / niid / ja / multimedia / 9368-2019-ncov.html> [Non-Patent Document 5] AC Walls et al. Cell 181, 281(2020). Nature homepage<URL:https: / / www.nature.com / articles / d41586-020-01444-z> [Non-Patent Document 6] Ken Ishihara. BME, vol.6, No.1, 1992, p.47. [Non-Patent Document 7] Committee on Equipment and Safety of the Japan Society of Ultrasound in Medicine (translation). Safe Use of Diagnostic Ultrasound (edited by Gail ter Haar). 2012. Japan Society of Ultrasound in Medicine website<URL:https: / / www.jsum.or.jp / committee / uesc / pdf / download.PDF> Summary of the Invention [Problem to be solved by the invention]

[0018] From the above 0012, if the diameter of the virus is 80~120nm, the ultrasonic frequency is 55~82MHz. 、 virus of It was required that the device vibrate in resonance with its inherent vibration, but in order to inactivate (destroy) the target virus, 1 solid However, as mentioned above, the diameter of all viruses is not uniform, and even viruses of the same species have different diameters, so naturally there is a range in the natural frequency calculated from the diameter of the virus.

[0019] In addition, the deeper the ultrasound waves enter the human body, the stronger the oscillation The higher the frequency, the more the energy is attenuated (Non-Patent Document 7). [Means for solving the problem]

[0021] FIG. 1 shows the present invention. Device The overall outline is shown below. 1 is the main body ( sweep Ultrasonic emission Faith Equipment), 8 is Infected patients A scanner that transmits ultrasound from the surface of the body into the body, Connect the main unit and the scanner 9 is the patient (in prone or supine position on the bed), and 10 is the scanner. of infected patients On the body surface Ultrasonic irradiation It is a trajectory.

[0022] The problem 0018 above can be solved by sweeping the frequency of the ultrasonic waves that are oscillated. An example of a frequency sweep is the signal for audio check. This is a sound source signal used to check audio amplifiers and speakers, starting from 20Hz, which is the range of human hearing, and outputting continuously up to 20,000Hz to check for abnormalities in the equipment, and is a common method among audiophiles.

[0023] For intellectual property information regarding the oscillation and control of the sweep signal, refer to Patent Document 2, etc. Figures 6 and 7 show graphs of waveform images when outputted with two different sweep frequency widths and sweep periods.

[0024] The problem in 0019 above can be solved by increasing or decreasing the output in accordance with the fluctuation of the sweep frequency (movement from high to low). In other words, the output is not constant, oscillation The lower the frequency, the smaller the output. oscillation The higher the frequency, the higher the output will be. Attenuation due to the depth of penetration is resolved by setting the maximum output while taking safety into account. Effect of the Invention

[0026] In the present invention, the characteristic frequency of a virus that infects humans is calculated using the Minnaert formula mentioned above, and ultrasonic vibrations are applied in accordance with the characteristic frequency. By this device Oscillation 、 body surface Ultrasound from Scan the hand This was born from the unprecedented idea of ​​inactivating (destroying) viruses in the body. This invention has the advantage that it is overwhelmingly cheaper, safer, and simpler than previous biochemical treatments (vaccines and antiviral drugs), and is not affected by viral mutations. economy If this treatment method becomes established, it is expected to set itself apart from previous virus treatments. [Brief description of the drawings]

[0027] [Figure 1]System overview and implementation image of the device of this invention [Diagram 2] Major virus types and sizes (excerpt) [Diagram 3] Electron microscope image of SARS-CоV-2 (new coronavirus) [Figure 4] Illustration of SARS-CоV-2 (new coronavirus). The spikes are the key to invading host cells, but judging from the electron microscope photo in Figure 3 and this illustration, it seems that they can be easily detached by subjecting the virus to vibration. [Diagram 5] Minnaert's formula and the resonant frequency obtained from it [Figure 6] Sweep signal setting example 1: Waveform image when sweep frequency range is set to 30 to 100 MHz and sweep period is set to 2 cycles / s [Figure 7] Sweep signal setting example 2: Waveform image when sweep frequency width is set to 40 to 80 MHz and sweep period is set to 7 cycles / s DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS

[0028] The structure and usage of the device of the present invention are simpler than those of existing ultrasound diagnostic devices, but because the target is an infectious virus, sufficient consideration and measures are required when using it. It is desirable for practitioners (doctors or technicians) to take thorough infection prevention measures and refer to the guidelines of the Japan Medical Association when providing treatment.

[0029] However, because the virus can be inactivated (destroyed) by the device of the present invention, even if a medical professional is infected, they can be cured by treatment with the device of the present invention, and it is expected that they will also acquire immunity. Therefore, the more infection spreads and the more patients are treated, the more the entire region will reach a state of herd immunity, and infection cure will prevail. Although we cannot be optimistic, it is conceivable that it could be treated on the same level as the measles virus. [Industrial Applicability]

[0030] Since the device of the present invention can be manufactured structurally at lower cost than an ultrasonic diagnostic device and is in worldwide demand, the required number was estimated as follows.

[0031] Assuming one unit per 1,000 people, the required number would be 130,000 in Japan (population 130 million) and 700,000 in the world (7 billion). Incidentally, the total number of AEDs (automated external defibrillators) sold in Japan (as of 2017) was approximately 1 million, which works out to one unit for every 130 people. [Explanation of symbols]

[0032] 1 Main unit Device ( sweep Ultrasonic emission Faith Device). 2 Frequency and output value input device. Enter the sweep frequency width, period, and output value. 3 Computing device. frequency High and low To Together, the output value Correction This prevents ultrasonic attenuation. 4 Frequency control device. sweep signal Control of. 5 Output control device. Controlling the output value. 6 Ultrasonic transmitter. 4 and 5 are combined to generate a sweep ultrasonic wave. Faith To make. 7 Connecting 1 and 8 cable. 8 From the surface of the body to the inside of the body sweep Emits ultrasonic waves Shake A scanner that does this. 9 Patients are treated in bed in either prone or supine position. 10. Scanner in body surface When scanning the ultrasound trajectory. 11 Image of the output waveform when the sweep frequency range is set to 30~100MHz and the sweep period is set to 2 cycles / s. 12 Waveform image when the sweep frequency range is set to 40~80MHz and the sweep period is set to 7 cycles / s.

Claims

[Claim 1] The device inactivates a virus in a patient's body by inducing a natural vibration of the virus by ultrasonic waves having a frequency that matches the natural vibration frequency of the virus, thereby vibrating the virus and destroying the virus by the natural vibration, The oscillation frequency that induces the inherent vibration is calculated from the Minnaert formula. However, since the size of all viruses that infect humans is not uniform, the oscillation ultrasonic wave is used as a sweep signal, A main unit (1) is provided which emits sweep ultrasonic waves which correspond to the characteristic frequencies of all the infected viruses, The inside of the main body device is configured to input the oscillation frequency and output value calculated from the Minnaert formula into a frequency / output value input device (2), and is equipped with a calculation device (3) that corrects the output value to match the high and low frequency. It is equipped with a frequency control device (4) and an output value control device (5), and transmits a sweep ultrasonic wave that integrates the frequency and output value from an ultrasonic transmitter (6), A sweep ultrasonic wave is generated by a scanner (8) via a cable (7), When the sweep ultrasound is irradiated onto the surface of the patient's body (10), the inherent vibration of the virus that has infected the patient is induced and resonates, The result is a virus inactivation device that has the characteristic of destroying and inactivating viruses within the body.

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