Cold syrup

Abstract

To provide a cold syrup containing a herbal medicine, an antipyretic analgesic, an antihistamine, a cough suppressant and an expectorant, which suppresses precipitation derived from the herbal medicine and has an excellent flavor when drunk. [Solution] A cold syrup containing an antipyretic analgesic, an antihistamine, a cough suppressant, and an expectorant, characterized in that it contains herbal medicines and polyoxyethylene hydrogenated castor oil, and the herbal medicines include at least one selected from the group consisting of Nandinaia Root, Ephedra Root, and Platycodon Grandiflorum.

Description

[Technical field]

[0001] The present invention relates to a cold syrup containing a herbal medicine, characterized in that it contains polyoxyethylene hydrogenated castor oil. [Background technology]

[0002] Cold syrups, which are a form of cold medicine, usually contain Western medicines (synthetic drugs) such as antipyretics, analgesics, antihistamines, cough suppressants, expectorants, and bronchodilators as active ingredients, as well as herbal medicines and Chinese herbal medicines. Western medicines are basically composed of a single ingredient, act on specific parts of the body or symptoms, and exert their effects according to the dosage. On the other hand, herbal medicines are derived in whole or in part from natural plants, minerals, animals, etc., and each herbal medicine contains multiple ingredients with various effects, while Chinese herbal medicines, which are a combination of multiple herbal medicines, contain a wide variety of ingredients. Therefore, herbal medicines and Chinese herbal medicines work widely from local to whole body, and have the effect of enhancing the body's natural healing power. Western medicines and herbal medicines and Chinese herbal medicines each have advantages that the other does not have, and it is expected that they will be used in the optimal combination. For example, Patent Document 1 proposes an oral liquid preparation (syrup) that combines the antipyretic and analgesic acetaminophen with sugar and licorice extract, while Patent Document 2 proposes an oral liquid preparation that combines vitamin B1 and herbal medicines. [Prior art documents] [Patent documents]

[0003] [Patent Document 1] Patent No. 3913795 [Patent Document 2] Patent No. 4403590 Summary of the Invention [Problem to be solved by the invention]

[0004] As mentioned above, herbal medicines and Kampo medicines are so to speak "mixtures" containing various ingredients, so there is a problem that liquid preparations containing these, such as syrups, tend to become cloudy or precipitate during storage. In addition, when ingredients that are difficult to ensure stability in aqueous solutions or ingredients that tend to crystallize are combined with herbal medicines or Kampo medicines, in addition to the occurrence of the above-mentioned precipitation, problems such as a decrease in content due to decomposition and crystallization (precipitation) of the ingredients may occur. To solve these problems, measures have been proposed, such as adding glycols (Patent Document 1) or adjusting the chloride ion concentration in the liquid (Patent Document 2).

[0005] Although the incorporation of solubilizers such as the above-mentioned glycols can suppress the occurrence of precipitation and the like in liquid preparations containing herbal medicines, the incorporation of the solubilizer can cause a strong bitter or acrid taste, which can lead to another problem in that the liquid preparation becomes difficult to drink. So far, there has been no proposal regarding a cold syrup that simultaneously solves the problems of precipitation and unpleasant taste derived from herbal medicines.

[0006] To provide a cold syrup which contains a herbal medicine, an antipyretic analgesic, an antihistamine, a cough suppressant and an expectorant, and which inhibits precipitation derived from the herbal medicine and has an excellent flavor when drunk. [Means for solving the problem]

[0007] That is, the present invention covers the following [1] to

[14] . [1] A cold syrup comprising an antipyretic, an analgesic, an antihistamine, a cough suppressant, and an expectorant, It is characterized by containing herbal medicine and polyoxyethylene hydrogenated castor oil, The cold syrup comprises at least one herbal medicine selected from the group consisting of Nantenjiu, Ephedra, and Platycodon grandiflorum. [2] The cold syrup according to [1], wherein the herbal medicine and the polyoxyethylene hydrogenated castor oil are contained in a mass ratio of herbal medicine (equivalent to raw herbal medicine):polyoxyethylene hydrogenated castor oil=1:0.01 to 1:2. [3] The cold syrup according to [1], wherein the herbal medicine is Nantenjiru and further contains licorice. [4] The cold syrup described in [1], wherein the herbal medicine is Ephedra. [5] The cold syrup described in [1], wherein the herbal medicine is bellflower. [6] The cold syrup described in [1], wherein the herbal medicine is formulated in the form of a herbal medicine containing at least one selected from the group consisting of Nandinacia officinalis, Ephedra Root, and Platycodon grandiflorum. [7] The cold syrup according to [1] further contains a bronchodilator. [8] The cold syrup according to [1], wherein the antipyretic and analgesic is acetaminophen. [9] The cold syrup according to [1], wherein the antihistamine is at least one selected from the group consisting of chlorpheniramine maleate, d-chlorpheniramine maleate, and diphenhydramine hydrochloride.

[10] The cold syrup according to [1], wherein the cough suppressant is at least one selected from the group consisting of dihydrocodeine phosphate, tipepidine citrate, and dextromethorphan hydrobromide hydrate.

[11] The cold syrup according to [1], wherein the expectorant is at least one selected from the group consisting of guaifenesin and potassium guaiacolsulfonate.

[12] The cold syrup described in [7], wherein the bronchodilator is dl-methylephedrine hydrochloride.

[13] The cold syrup according to any one of [1] to

[12] , further comprising, as other ingredients, at least one selected from the group consisting of alloclamide hydrochloride, cloperastine hydrochloride, cloperastine fendizoate, codeine phosphate hydrate, dibunate sodium, tipepidine hibenzate, dextromethorphan phenolphthaline salt, pentoxyverine citrate, dimemorfan phosphate, noscapine, noscapine hydrochloride hydrate, dl-methylephedrine saccharin salt, potassium cresolsulfonate, bromhexine hydrochloride, L-carbocysteine, L-ethylcysteine ​​hydrochloride, belladonna total alkaloids, isopropamide iodide, senega, ginger, zhilichuan rhizome, ginseng, and oak.

[14] The cold syrup according to claim [1], wherein the polyoxyethylene hydrogenated castor oil is contained in an amount of 60 mg to 1000 mg per 120 mL of the total amount of the cold syrup. Effect of the Invention

[0008] According to the present invention, by blending polyoxyethylene hydrogenated castor oil in a cold syrup containing herbal medicines, it is possible to suppress turbidity, precipitates, and sedimentation, and to prevent bitterness and unpleasant taste when drinking. It is possible to provide a cold syrup which has both storage stability and ease of drinking by suppressing unpleasant flavors such as mucilage. DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS

[0009] [Cold syrup] The cold syrup of the present invention contains an antipyretic analgesic, an antihistamine, a cough suppressant, and an expectorant, and is characterized by containing herbal medicines and polyoxyethylene hydrogenated castor oil. Furthermore, since cold syrups are usually preparations for children, it is desirable to use ingredients that are safer, and it is undesirable to use ingredients that are generally contraindicated for use by people under the age of 15.

[0010] <Herbal medicine> The herbal medicines used in the cold syrup of the present invention are at least one or more selected from the group consisting of Nantenjitsu (Nanten fruit), Ephedra (Maou), and Platycodon grandiflorum (Platycodon grandiflorum). These herbal medicines have the efficacy (antitussive and expectorant effects) in suppressing cough and phlegm. In addition to the above herbal medicines, other herbal medicines that have a proven track record of use in cold medicines, such as licorice, senega, ginger, earth dragon, ginseng, and cherry bark, which have antitussive and expectorant effects, blood circulation promoting effects (body warming effects), fever reducing effects, and tonic effects, may also be used in combination. For example, a combination of Nantenjiku and Licorice, Ephedra Root alone, and Platycodon grandiflorum alone can be used, but are not limited thereto. In addition, the above-mentioned Nantenjitsu, Ephedra, and Platycodon grandiflorum can be incorporated in the cold syrup of the present invention in the form of a herbal medicine (a combination of multiple herbal medicines) containing at least one of these. Examples of such herbal medicines include, but are not limited to, Kakkonto (herbal medicine composition: Kakkon, Ephedra, Taisou, Cinnamon Bark or Cinnamon Bark, Peony Root, Licorice, Shokyo or Raw Shokyo), Kakkonto Ka Kikyo (herbal medicine composition: Kakkonto plus Platycodon grandiflorum), Shoseiryuto (herbal medicine composition: Ephedra, Peony Root, Kankyo or Shokyo, Licorice, Cinnamon Bark, Saishin, Gomishi, Hange), and Mao-to (herbal medicine composition: Ephedra, Cinnamon Bark, Apricot Nin, Licorice) and the like.

[0011] The herbal medicines to be added to the cold syrup of the present invention are preferably added in the form of an extract. The extract is produced by a conventional method, for example, a method of extracting the herbal medicine raw material at an appropriate temperature (low temperature or heat) using an extraction solvent. The extraction solvent can be appropriately selected depending on the herbal medicine, but preferably water, a hydrophilic solvent (especially ethanol) and a mixed solvent thereof are used. In this specification, the extract can be used as a liquid extract as it is, or it can be used as a diluted liquid extract with water or the like, a concentrated liquid extract, or a dried liquid extract. That is, the extract used in the present invention can be any of a dried extract, a soft extract, a liquid extract, a tincture, etc.

[0012] <Polyoxyethylene hydrogenated castor oil> The cold syrup of the present invention is characterized by the use of polyoxyethylene hydrogenated castor oil together with the above-mentioned herbal medicines. Polyoxyethylene hydrogenated castor oil acts as a solubilizer, dispersant, and stabilizer, and can suppress precipitation and other problems in the cold syrup containing the herbal medicines of the present invention, as well as unpleasant tastes such as bitterness and astringency. Examples of polyoxyethylene hydrogenated castor oils that can be incorporated into the cold syrup of the present invention include polyoxyethylene hydrogenated castor oil 40, polyoxyethylene hydrogenated castor oil 50, and polyoxyethylene hydrogenated castor oil 60, which can be incorporated alone or in combination. Polyoxyethylene hydrogenated castor oil can be blended in an amount of 60 mg to 1000 mg in a total volume of 120 mL of cold syrup, for example. In addition, polyoxyethylene hydrogenated castor oil can be blended in a ratio of, for example, the amount of the herbal medicine (equivalent to the amount of the raw herbal medicine:polyoxyethylene hydrogenated castor oil = 1:0.01 to 1:2 (mass ratio) relative to the amount of the raw herbal medicine blended. The term "original herbal medicine equivalent" means expressing the amount of herbal medicine that may be contained in various forms based on the dry weight of the plant material required to obtain it (for example, the dry weight of the bark, branches, fruit, etc. of the plant, or the dry weight of the processed product that has been subjected to only physical processing such as fine pieces or powder of said parts). For example, when 10 parts by mass of cinnamon extract powder is obtained from 100 parts by mass of dried cinnamon, 10 mg of said extract powder is expressed as 100 mg of original herbal medicine equivalent.

[0013] <Antipyretics and analgesics> As mentioned above, when it comes to cold syrups for children, it is advisable to refrain from using certain non-steroidal anti-inflammatory drugs (NSAIDs), which have been shown to increase the risk of causing influenza-related encephalopathy accompanied by high fever, loss of consciousness, and convulsions when used to reduce fever from influenza or chickenpox. For these reasons, it is preferable to use acetaminophen as the antipyretic and analgesic agent in the cold syrup of the present invention.

[0014] <Antihistamines> The antihistamine used in the cold syrup of the present invention is preferably at least one selected from the group consisting of chlorpheniramine maleate, d-chlorpheniramine maleate, and diphenhydramine hydrochloride, which may be used alone or in combination.

[0015] <Cough suppressants> The antitussive agent used in the cold syrup of the present invention is preferably at least one selected from the group consisting of dihydrocodeine phosphate, tipepidine citrate, and dextromethorphan hydrobromide hydrate. These may be used alone or in combination.

[0016] <Expectorants> The expectorant used in the cold syrup of the present invention may be at least one selected from the group consisting of guaifenesin and potassium guaiacolsulfonate. These may be used alone or in combination.

[0017] Bronchodilators The cold syrup of the present invention may also contain a bronchodilator, such as dl-methylephedrine hydrochloride.

[0018] <Other ingredients> The cold syrup of the present invention may contain other ingredients as long as the effects of the present invention are not impaired. For example, antitussives such as alloclamide hydrochloride, cloperastine hydrochloride, cloperastine fendizoate, codeine phosphate hydrate, dibunate sodium, tipepidine hibenzate, dextromethorphan phenolphthaline salt, pentoxyverine citrate, dimemorfan phosphate, noscapine, and noscapine hydrochloride hydrate; bronchodilators such as dl-methylephedrine saccharin salt; expectorants such as airway mucosal secretion promoters such as potassium cresol sulfonate and bromhexine hydrochloride, and airway mucolytic agents such as L-carbocysteine ​​and L-ethylcysteine ​​hydrochloride; parasympathetic nervous system agents such as belladonna total alkaloids and isopropamide iodide. Examples of the components that can be used include a blood-blocking component (for relieving runny nose), etc. These can be used alone or in combination.

[0019] In addition, optional ingredients such as conventional ingredients usually blended into liquids or syrups, for example, pH adjusters and buffers such as citric acid, sodium citrate, hydrochloric acid, sodium chloride, sodium hydroxide, etc.; solubilizers such as ethanol, propylene glycol, etc.; stabilizers and preservatives such as sodium benzoate, alkylparabens, ethyl parahydroxybenzoate, butyl parahydroxybenzoate, etc.; sweeteners such as sucrose, sorbitol, etc.; colorants such as caramel, etc.; and flavors may be blended. Polysorbates, which are generally used as solubilizers or emulsifiers in liquid preparations, are effective in suppressing precipitation, but they deteriorate the flavor of cold syrups, so they must be used with care and it is preferable not to use them at all.

[0020] The cold syrup of the present invention can be produced by dissolving the above-mentioned essential components and necessary optional components in purified water under heating and / or stirring as necessary. As mentioned above, the herbal medicine may be dissolved in the form of a herbal medicine containing multiple types of herbal medicine. Alternatively, a mixture containing several types of components may be prepared in multiple portions, and the multiple mixtures may be combined to prepare the cold syrup.

[0021] In the cold syrup of the present invention, the amount of each component is not particularly limited as long as it is within a range that allows the desired effects to be obtained, and can be, for example, as follows relative to the total amount of cold syrup (100% by mass): Herbal medicine: 0.5-5.0% by weight Polyoxyethylene hydrogenated castor oil: 0.05 to 0.83% by mass Antipyretics and analgesics: 0.25-0.50% by weight Antihistamines: 0.001 to 0.042% by weight Cough suppressants: 0.007 to 0.033% by weight Expectorant: 0.05-0.14% by weight Other ingredients: Residual The other ingredients may be, for example, 10-60% by mass of sweeteners such as sucrose and sorbitol (amount added when blended, the same applies below), 1-10% by mass of solubilizers such as ethanol and propylene glycol, 10-80% by mass of purified water, and 0.1-5% by mass of flavorings, colorants, pH adjusters, stabilizers, etc. The other ingredients are not limited to these, and ingredients that are usually added to liquid preparations such as cold syrup can be blended as appropriate, and the blending of other ingredients is not essential. EXAMPLES

[0022] The present invention will be described in more detail below with reference to examples, although the present invention is not limited to these examples.

[0023] [Preparation of cold syrup] Example 1 A suitable amount of purified water was added to 550 mg of licorice extract, and after pretreatment with a filter aid, 200 mg of polyoxyethylene hydrogenated castor oil 60, 8 g of D-sorbitol solution (70%), 600 mg of acetaminophen, and 36 g of sucrose were added and dissolved. 1.8 mL of Nandinacia oleracea extract, 40 mg of dl-methylephedrine hydrochloride, 30 mg of dextromethorphan hydrobromide, 50 mg of diphenhydramine hydrochloride, 160 mg of potassium guaiacolsulfonate, and 70 mg of sodium benzoate were added and dissolved. 0.12 mL of flavor and 1.6 mg of coloring agent were added and dissolved. The pH was adjusted to 5.5 with a suitable amount of sodium citrate hydrate and citric acid hydrate, and purified water was added to make the total volume 120 mL, to obtain the cold syrup of Example 1.

[0024] Example 2 A cold syrup of Example 2 was obtained in the same manner as in Example 1, except that dl-methylephedrine hydrochloride was not added.

[0025] Example 3 The cold syrup of Example 3 was obtained in the same manner as in Example 1, except that 100 mg of Ephedra extract was added instead of dl-methylephedrine hydrochloride, Nandinacia fluid extract, and Licorice extract in Example 1, and the amount of polyoxyethylene hydrogenated castor oil 60 was changed to 1000 mg.

[0026] Example 4 The cold syrup of Example 4 was obtained in the same manner as in Example 1, except that 200 mg of polyoxyethylene hydrogenated castor oil 50 was added instead of polyoxyethylene hydrogenated castor oil 60 in Example 1.

[0027] Example 5 The cold syrup of Example 5 was obtained in the same manner as Example 1, except that 6,000 mg of platycodon liquid extract was added instead of the Nandinacia fluid extract and licorice extract in Example 1, and the amount of polyoxyethylene hydrogenated castor oil 60 was changed to 1,000 mg.

[0028] Example 6 The cold syrup of Example 6 was obtained in the same manner as Example 1, except that 4,000 mg of platycodon liquid extract was added instead of the Nandinacia fluid extract and licorice extract in Example 1, and the amount of polyoxyethylene hydrogenated castor oil 60 was 600 mg.

[0029] Comparative Example 1 A cold syrup of Comparative Example 1 was obtained in the same manner as in Example 1, except that 600 mg of polysorbate 80 was added instead of polyoxyethylene hydrogenated castor oil 60 in Example 1.

[0030] Comparative Example 2 A cold syrup of Comparative Example 2 was obtained in the same manner as in Example 1, except that polyoxyethylene hydrogenated castor oil 60 was not added.

[0031] Comparative Example 3 A cold syrup of Comparative Example 3 was obtained in the same manner as in Example 1, except that 100 mg of Ephedra extract was added instead of dl-methylephedrine hydrochloride, Nandinacia fluid extract, and Licorice extract in Example 1, and 600 mg of polysorbate 80 was added instead of polyoxyethylene hydrogenated castor oil 60.

[0032] Comparative Example 4 A cold syrup of Comparative Example 4 was obtained in the same manner as in Example 1, except that 100 mg of Ephedra extract was added instead of dl-methylephedrine hydrochloride, Nandinacia fluid extract, and Licorice extract in Example 1, and polyoxyethylene hydrogenated castor oil 60 was not added.

[0033] Comparative Example 5 A cold syrup of Comparative Example 5 was obtained in the same manner as in Example 1, except that 600 mg of polysorbate 60 was added instead of polyoxyethylene hydrogenated castor oil 60 in Example 1.

[0034] Comparative Example 6 The cold syrup of Comparative Example 6 was obtained in the same manner as in Example 1, except that 6,000 mg of platycodon liquid extract was added instead of the Nandinacia fluid extract and the licorice extract in Example 1, and 1,000 mg of polysorbate 80 was added instead of the polyoxyethylene hydrogenated castor oil 60.

[0035] Comparative Example 7 The cold syrup of Comparative Example 7 was obtained in the same manner as in Example 1, except that 6,000 mg of platycodon liquid extract was added instead of the Nandinacia fluid extract and the licorice extract in Example 1, and polyoxyethylene hydrogenated castor oil 60 was not added.

[0036] Comparative Example 8 The cold syrup of Comparative Example 8 was obtained in the same manner as in Example 1, except that 4,000 mg of platycodon liquid extract was added instead of the Nandinacia fluid extract and the licorice extract in Example 1, and 600 mg of polysorbate 80 was added instead of the polyoxyethylene hydrogenated castor oil 60.

[0037] Comparative Example 9 The cold syrup of Comparative Example 9 was obtained in the same manner as in Example 1, except that 4,000 mg of platycodon liquid extract was added instead of the Nandinacia fluid extract and the licorice extract in Example 1, and polyoxyethylene hydrogenated castor oil 60 was not added.

[0038] [Test Example 1: Appearance] 60 mL of each of the cold syrups of Examples 1 to 6 and Comparative Examples 1 to 9 was placed in a transparent glass container (a standard 7K glass bottle, full capacity: 75.5 mL, inner mouth diameter: 29 mm, body diameter: 43 mm, body height: 78 mm), and the appearance of the content liquid was visually observed from the side of the standard bottle. Suppression of turbidity was evaluated according to the following criteria. <Appearance evaluation criteria> 〇: No turbidity or precipitate ×: Significant turbidity or precipitates are present

[0039] [Test Example 2: Taste] An appropriate amount of each of the cold syrups of Examples 1 to 6 and Comparative Examples 1 to 9 was placed in the mouth, and a sensory evaluation was performed according to the following criteria. <Taste evaluation criteria> 〇: Easy to drink with little bitterness or astringency ×: Strong bitterness and acrid taste, difficult to drink

[0040] [Test Example 3: Stability (presence or absence of precipitation after storage)] The cold syrups of Examples 1 to 6 and Comparative Examples 1 to 9 were placed in the 7K standard bottles used in the above Test Example 1 and stored for 7 days under conditions of 40°C±2°C / 75% RH±5% RH. After the storage, the state of the contents was visually observed while irradiating light from the bottom of the container. The presence or absence of precipitation was evaluated according to the following criteria. <Stability evaluation criteria> ○: No precipitation occurs ×: Precipitation occurs

[0041] The formulations of the cold syrups prepared in the present Examples and Comparative Examples, as well as the evaluation results of Test Examples 1 to 3, are shown in Tables 1 and 2.

[0042] [Table 1]

[0043] [Table 2]

[0044] A formulation (Example 1) containing acetaminophen (antipyretic analgesic), diphenhydramine hydrochloride (antihistamine), dextromethorphan hydrobromide (antitussive), potassium guaiacolsulfonate (expectorant), dl-methylephedrine hydrochloride (bronchodilator), Nandinacia oleracea extract (herbal medicine), and Licorice extract (herbal medicine) and polyoxyethylene hydrogenated castor oil (HCO-60) had an appearance free of turbidity or precipitate, and no precipitation was observed even after 7 days of storage under the conditions of 40°C ± 2°C / 75% RH ± 5% RH, and the taste was not bitter and easy to drink. Similarly, a formulation (Example 4) in which polyoxyethylene hydrogenated castor oil 60 in the formulation of Example 1 was replaced with polyoxyethylene hydrogenated castor oil 50 also had an appearance free of turbidity or precipitate, and no precipitation was observed even after 7 days of storage, and the taste was not bitter and easy to drink. Similar results were also obtained in a formulation of Example 1 that did not use the bronchodilator dl-methylephedrine hydrochloride (Example 2), in a formulation of Example 1 that included ephedra extract instead of dl-methylephedrine hydrochloride, Nandinacia fluid extract, and licorice extract (Example 3), and in a formulation of Example 1 that included platycodon extract instead of Nandinacia fluid extract and licorice extract (Examples 5 and 6).

[0045] On the other hand, in the formulation of Example 1, instead of polyoxyethylene hydrogenated castor oil (HCO-60), a formulation containing polysorbate 80, a general solubilizer (Comparative Example 1), the appearance was good, and the precipitation was also suppressed after the above-mentioned 7-day storage, but the taste was bad with bitterness and harshness. Similarly, in the formulation of Example 3, the formulation in which polyoxyethylene hydrogenated castor oil (HCO-60) was replaced with polysorbate 80 (Comparative Example 3), in the formulation of Example 4, the formulation in which polyoxyethylene hydrogenated castor oil (HCO-50) was replaced with polysorbate 60 (Comparative Example 5), and in the formulation of Example 5, the formulation in which polyoxyethylene hydrogenated castor oil (HCO-60) was replaced with polysorbate 80 (Comparative Example 6) had no problems with the appearance or the suppression of precipitation after 7-day storage, but the taste was bad. In addition, in the formulation of Example 6, in which polyoxyethylene hydrogenated castor oil (HCO-60) was replaced with polysorbate 80 (Comparative Example 8), the appearance was good but the taste was poor, and precipitation was observed after storage for 7 days. In the formulation of Example 1, the formulation (Comparative Example 2) not using polyoxyethylene hydrogenated castor oil (HCO-60) had a good taste, but showed a noticeable turbidity and precipitates in appearance, and clear precipitation was observed after the above-mentioned 7-day storage. Similarly, in the formulation of Example 3, the formulation (Comparative Example 4) not using polyoxyethylene hydrogenated castor oil (HCO-60) also had no problem with taste, but had problems with appearance and precipitation suppression. Furthermore, in the formulation of Example 5, the formulation (Comparative Example 7) not using polyoxyethylene hydrogenated castor oil (HCO-60) and in the formulation of Example 6, the formulation (Comparative Example 9) not using polyoxyethylene hydrogenated castor oil (HCO-60) had no problem with taste and appearance, but precipitation was confirmed after 7 days of storage, and it was found to have a problem with precipitation suppression.

[0046] From the above results, it was confirmed that the incorporation of polyoxyethylene hydrogenated castor oil is useful for cold syrups containing herbal medicines, as well as antipyretics, antihistamines, cough suppressants, and expectorants, which have a good appearance free of turbidity or precipitates, a good flavor free of bitterness or acridness when drunk, and have no stability problems without forming precipitates after storage.

Claims

1. Acetaminophen, an antipyretic and analgesic diphenhydramine hydrochloride, an antihistamine; Dextromethorphan hydrobromide hydrate, a cough suppressant; and A cold syrup containing an expectorant, potassium guaiacolsulfonate, It is characterized by containing herbal medicine and polyoxyethylene hydrogenated castor oil, A cold syrup, the herbal medicine of which includes Nantenjiru.

2. 2. The cold syrup according to claim 1, wherein the herbal medicine and the polyoxyethylene hydrogenated castor oil are contained in a mass ratio of herbal medicine (equivalent to raw herbal medicine):polyoxyethylene hydrogenated castor oil=1:0.01 to 1:

2.

3. 2. The cold syrup of claim 1, wherein the herbal medicine further comprises licorice.

4. The cold syrup according to claim 1, wherein the herbal medicine is formulated in the form of a traditional Chinese medicine containing Nantenjiu.

5. 2. The cold syrup of claim 1, further comprising dl-methylephedrine hydrochloride as a bronchodilator.

6. 2. The cold syrup according to claim 1, wherein the polyoxyethylene hydrogenated castor oil is contained in an amount of 60 mg to 1000 mg per 120 mL of the total amount of cold syrup.

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