Alternating magnetic stimulation and personalized cognitive training methods, devices, and systems

Abstract

The present invention relates to an alternating magnetic stimulation method and a personalized cognitive training method, device, and system. The magnetic stimulation system according to one embodiment of the present invention includes a control unit that determines a corresponding magnetic field output in consideration of user data including a motor threshold and a brain region to be stimulated, and a power module that is connected to a coil that generates a magnetic field and supplies power so that the coil generates the determined magnetic field. The control unit may include a motor threshold measurement module that measures the user's motor threshold using a magnetic field adjustment module, and a magnetic field adjustment module that adjusts magnetic field-related parameters to control the magnetic field output determined based on the user's brain state including the distance to the brain region to be stimulated and at least one of the user's brain morphology, size, and head shape, and the measured motor threshold, using the user's MRI image.

Description

[Technical field]

[0001] The present invention relates to alternating magnetic stimulation and personalized cognitive training methods, devices, and systems. [Background technology]

[0002] Magnetic stimulation methods such as transcranial magnetic stimulation (TMS) are a method of non-invasively stimulating nerve cells in the brain using magnetic energy. By passing a strong magnetic field through the skull from near the head to activate nerve cells, it is possible to treat psychiatric conditions such as depression or neurological conditions such as dementia.

[0003] Conventionally, in order to position a coil that generates a magnetic field at the part of the brain that should receive magnetic stimulation, a medical professional such as a nurse had to position the coil directly. In this case, it took a lot of time to position the coil accurately, halving the efficiency of treatment.

[0004] In addition, cognitive training can be performed alternately with the transcranial magnetic stimulation method to maximize the stimulation activation of brain regions. In particular, cognitive training can be performed for various reasons, but can be used to improve or prevent cognitive impairment, for example, for patients with senile cognitive impairment, especially senile dementia.

[0005] However, conventional cognitive training has classified users based solely on the state of their brains, without taking into account the characteristics of each individual user. This ignores the fact that even if users have the same state of dementia, the questions and difficulty that activate the brain may differ depending on the user's history.

[0006] Therefore, for transcranial magnetic stimulation, a magnetic stimulation system that accurately positions a coil at the location of the brain to be stimulated is needed, and there is a need for personalized cognitive training that can adjust the items and levels taking into account user data so that the cognitive training performed in conjunction with this can substantially and sustainably activate the user's brain. Summary of the Invention [Problem to be solved by the invention]

[0007] The present invention is intended to solve the above-mentioned problems in the conventional art, and has an objective of providing a magnetic stimulation system and method capable of detecting a user's motor threshold by adjusting a magnetic field output so as to determine a magnetic field output suitable for each user, and a personalized cognitive training method and device capable of performing personalized cognitive training for each user using data for each user and a structured database. [Means for solving the problem]

[0008] In accordance with a first aspect of the present invention, a magnetic stimulation system according to an embodiment of the present invention includes a controller that determines a corresponding magnetic field output in consideration of user data including a motor threshold and a brain region to be stimulated, and a power module that is connected to a coil that generates a magnetic field and supplies power to the coil to generate the determined magnetic field, the controller including a motor threshold measurement module that measures the motor threshold of a user using a magnetic field control module, and a magnetic field control module that adjusts related parameters of the magnetic field to control a magnetic field output, the motor threshold measurement module measures the user's motor threshold by gradually adjusting a magnetic field strength using the magnetic field control module, and when the magnetic field strength reaches a maximum magnetic field output, increases a magnetic field frequency by a preset ratio and then further gradually adjusts the magnetic field strength to measure the user's motor threshold, and the magnetic field control module may include a magnetic field generator that determines a magnetic field output based on a distance to a brain region to be stimulated and a state of the user's brain including at least one of a morphology, size, and shape of the user's brain, and the measured motor threshold, using a received MRI image of the user.

[0009] In a second aspect of the present invention, a magnetic stimulation method includes a magnetic field generating device including a control unit that determines a corresponding magnetic field output in consideration of user data including a motor threshold and a brain region to be stimulated, and a power module that is connected to a coil that generates a magnetic field and supplies power so that the coil generates the determined magnetic field, the magnetic field generating device including a control unit that determines a corresponding magnetic field output in consideration of user data including a motor threshold and a brain region to be stimulated, and a power module that is connected to a coil that generates a magnetic field and supplies power so that the coil generates the determined magnetic field, the magnetic field generating device including a control unit that determines a corresponding magnetic field output in consideration of a motor threshold and a brain region to be stimulated, the ... motor cortex of the user, the magnetic field generating device including a control unit that determines The method may include a first step of stimulating the neuromuscularis (Neuropathy Cortex) with a magnetic field to check whether there is finger movement or a change in motor threshold using a motor threshold measurement sensor, a second step of increasing the magnetic field strength at a preset ratio if there is no finger movement or change in motor threshold until finger movement or a change in motor threshold occurs, and a third step of increasing the magnetic field frequency and returning to the second step when the magnetic field strength reaches a maximum magnetic field output.

[0010] Meanwhile, as a third aspect of the present invention, a personalized cognitive training method performed by a cognitive training device can be provided. The personalized cognitive training method according to one embodiment of the present invention includes a step of, when user data is input into the device, a question setting unit setting a predetermined type of question according to the brain area to be trained (the questions are classified according to level and type), a step of a score determination unit determining a cognitive training result score based on feedback provided by the user for the set questions, and a step of a question change unit determining questions for the next round based on the cognitive training result score of the current round, wherein the step of determining questions for the next round may include changing the question type for the next round based on the cognitive training result score.

[0011] In addition, as a fourth aspect of the present invention, there is provided a personalized cognitive training device for performing multiple cognitive training exercises, comprising: a content storage unit for storing content used for question setting, which is classified by stage or item; a question setting unit for setting questions for corresponding cognitive training exercises in consideration of brain areas activated by cognitive training and user data (the questions are classified by level and type); a score determination unit for determining whether or not to maintain the score range or score obtained for the questions set by the question setting unit; and a question modification unit for modifying the level of the questions or the pool of questions based on the results of the score determination unit, wherein the question modification unit may include a level adjustment module for adjusting the level of the questions so that a preset optimal score range is maintained, and a pool conversion module for changing the question type for the next round based on the obtained cognitive training result score.

[0012] In addition, as a fifth aspect of the present invention, there can be provided a computer-readable recording medium having recorded thereon a program for executing the magnetic stimulation method of the second aspect or the personalized cognitive training method of the third aspect on a computer. Effect of the Invention

[0013] A magnetic stimulation system according to one embodiment of the present invention can constantly measure the motor threshold of each user before magnetic stimulation and adjust the magnetic field output based on the critical value of the motor threshold, thereby enabling magnetic stimulation to be performed without user movement in a manner that maximizes the efficiency of brain stimulation, thereby improving therapeutic efficiency.

[0014] In addition, the personalized cognitive training method and device according to one embodiment of the present invention, which is performed simultaneously or alternately with the above-mentioned magnetic stimulation, can adjust and present questions for each type, stage, and item so that brain stimulation is performed according to the relevance to user data, thereby enabling personalized cognitive training for each user and improving the efficiency of brain activation and the efficiency of user treatment. [Brief description of the drawings]

[0015] [Figure 1] FIG. 1 shows a schematic diagram of a human brain and corresponding coils to explain magnetic stimulation methods. [Diagram 2] 1 is a block diagram showing a schematic configuration of a magnetic field generating device according to an embodiment of the present invention; [Diagram 3] 1 is a schematic block diagram showing the configuration of a brain navigation device according to an embodiment of the present invention; [Figure 4] 1 is a schematic block diagram illustrating the configuration of an entire magnetic stimulation system including a magnetic field generating device and a navigation device according to an embodiment of the present invention. [Diagram 5] 1 illustrates a flow chart of a motor threshold measurement module for measuring a motor threshold according to one embodiment of the present invention. [Figure 6] 1 shows a flow chart for detecting brain location regions to be stimulated according to an embodiment of the present invention. [Figure 7] 1 shows coordinates displaying location data of a brain location region to be stimulated according to an embodiment of the present invention. [Figure 8] 1 is a schematic block diagram showing the configuration of an entire magnetic stimulation system including a magnetic field generating device using multiple coils and a navigation device according to another embodiment of the present invention. [Figure 9] 1 shows a flow chart of a magnetic stimulation method according to an embodiment of the present invention. [Figure 10] 1 illustrates a flow chart of a motor threshold detection method according to an embodiment of the present invention. [Figure 11] 1 is a block diagram showing a schematic configuration of a personalized cognitive training device according to an embodiment of the present invention; [Figure 12] 2 is a block diagram showing a schematic configuration of a content storage unit according to an embodiment of the present invention; FIG. [Figure 13] 1 illustrates a structure in which a content storage unit according to an embodiment of the present invention classifies and stores words. [Figure 14]13 illustrates a structure for classifying and storing words in a content storage unit according to another embodiment of the present invention. [Figure 15] 1 shows a flow chart of a personalized cognitive training method according to one embodiment of the present invention. [Figure 16] 1 illustrates a flow chart for adjusting a level of a personalized cognitive training method according to an embodiment of the present invention. [Figure 17] 1 illustrates a flow chart for level adjustment and question pool adjustment of a personalized cognitive training method according to an embodiment of the present invention. [Figure 18] 1 illustrates a flow chart for adjusting a problem pool of a personalized cognitive training method according to an embodiment of the present invention. [Figure 19] 1 shows a flowchart for adjusting the level and question pool taking into account user data in a personalized cognitive training method according to an embodiment of the present invention. [Figure 20] 13 is a schematic block diagram illustrating a configuration and operation of a control unit according to another embodiment of the present invention. [Figure 21] 11 illustrates a manner in which a word analysis and classification module classifies words according to another embodiment of the present invention. [Figure 22] 13 illustrates a flowchart for classifying words by a word analysis and classification module according to another embodiment of the present invention. DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS

[0016] Hereinafter, an embodiment of the present invention will be described with reference to the accompanying drawings. However, the embodiment of the present invention can be modified into various other forms, and the scope of the present invention is not limited to only the embodiment described below. The shape and size of elements in the drawings may be exaggerated for clearer explanation, and elements represented by the same reference numerals in the drawings are the same elements.

[0017] Hereinafter, a user is defined as a person who receives magnetic stimulation or controls a magnetic stimulation system to receive magnetic stimulation, or a person who receives personalized cognitive training or controls a personalized cognitive training device to receive personalized cognitive training. A cognitively impaired patient, such as a patient with senile dementia or a patient with other types of cognitive impairment, is merely one embodiment of a user, and the user is not limited to a patient. In addition, a user includes a user who receives magnetic stimulation and a user who uses a device to receive magnetic stimulation, and hereinafter, a user mainly means a user who receives magnetic stimulation.

[0018] In addition, the present invention can be used in cognitive training that is performed for various reasons, and can be used to help children's brain development, or to help activate the brain when brain development has declined due to cognitive disorders, etc., for therapeutic or preventive purposes.

[0019] In particular, the present invention can be used to treat and prevent geriatric cognitive impairment, such as memory impairment resulting from memory loss and dementia diseases such as Alzheimer's disease, which is a neurodegenerative disease. Cognitive training can prevent a decline in brain activity and treat or prevent diseases such as cognitive impairment.

[0020] FIG. 1 is a schematic diagram of a human brain and a corresponding coil to explain a magnetic stimulation method. As shown in FIG. 1, the magnetic stimulation method includes TMS, TDCS (Transcranial Direct Current Stimulation), etc. In particular, the TMS method is a non-surgical brain stimulation method that stimulates specific parts of the brain with a magnetic field generated by a conductive electromagnetic coil to activate nerve cells. When a strong current is applied to the coil to generate a magnetic field, the strong magnetic field generated by the coil positioned corresponding to the head induces a bioelectric current in the user's brain nerve cells, and the induced current stimulates the brain nerve cells.

[0021] Therefore, it is possible to provide a brain stimulating therapy as a psychiatric or neurological treatment for cases in which brain nerve cells cannot be smoothly activated, such as the treatment of depression or dementia.

[0022] In particular, although a circular coil may be used, by using a coil in the shape of an eight, a sharp tip of the magnetic field is formed at the junction of the two coils, thereby enabling localized stimulation.

[0023] Figure 2 is a schematic block diagram showing the configuration of a magnetic field generating device according to one embodiment of the present invention, Figure 3 is a schematic block diagram showing the configuration of a brain navigation device according to one embodiment of the present invention, and Figure 4 is a schematic block diagram showing the configuration of an entire magnetic stimulation system including a magnetic field generating device and a navigation device according to one embodiment of the present invention.

[0024] Below, the overall magnetic stimulation system is described, followed by a description of each device within the magnetic stimulation system.

[0025] Magnetic Stimulation System As shown in FIG. 4 , the magnetic stimulation system may include a magnetic field generating device 100 , a brain navigation device 200 , an integrated operator 300 , and a cognitive training device 400 .

[0026] With reference to the chair 10 on which the user sits, the coil 160 is disposed on the side where the user's brain is located, and the coil 160 and the magnetic field generating device 100 can be linked together.

[0027] The magnetic field generating device 100 according to one embodiment of the present invention is a device that determines and provides a magnetic field output to the coil 160 to provide magnetic field stimulation to the user's brain.

[0028] The magnetic field generating device 100 according to an embodiment of the present invention may include a control unit 110 that determines a corresponding magnetic field in consideration of user data including a motor threshold (MT) and a brain region to be stimulated, and a power module 120 that is connected to the control unit 110 and a coil 160 that generates a magnetic field and supplies power to the coil 160 to generate the determined magnetic field. A power conversion module 121 may be included to convert and supply alternating current (AC) power to the power module 120.

[0029] According to one embodiment of the present invention, the magnetic field generating device 100 may include a user interface 150 including an output module 152 for displaying the output magnetic field to a user controlling the magnetic field generating device 100 and an input module 151 for the user to manually adjust the magnetic field output, a communication module 130 for communicating with an integrated operator 300 and a brain navigation device 200, and a cooling module 140 including a temperature monitoring unit 142 for monitoring the temperature of the coil 160 and a cooling unit 141 for cooling when the temperature exceeds a critical value.

[0030] In addition, the brain navigation device 200 according to one embodiment of the present invention is a device that works in conjunction with the magnetic field generating device 100 to detect the position of the brain region to be stimulated and provide the magnetic field generating device 100 with position information of the brain region to guide the position of the magnetic field generating device 100 so that the magnetic field generating device 100 can be accurately positioned at the position of the user's brain region to be stimulated.

[0031] A brain navigation device 200 according to one embodiment of the present invention includes an MRI data memory 210 that receives and stores an MRI image of a user and position data of the brain region to be stimulated, and can include mapping modules 221, 222 that capture an actual head image of the user in real time using a camera unit 221, and map the user's brain MRI image, which displays the position data of the brain region to be stimulated and is stored in the MRI data memory 210, to the actual head image captured in real time.

[0032] The device may further include a laser scanner 230 that scans the user's head to detect a head position corresponding to the location of the brain region to be stimulated, and a laser pointer 240 that displays the head position corresponding to the location of the brain region detected by the laser scanner 230.

[0033] Alternatively, the robot arm can be moved to the position of the head photographed by the camera unit 221 so as to detect the head position corresponding to the position of the brain region to be stimulated.

[0034] That is, in one embodiment, the brain navigation device 200 may include an MRI data memory 210 and mapping modules 221, 222, and may further include a laser scanner 230 and a laser pointer 240 to easily locate the location of the brain area to be stimulated on the user's actual head, or may further include a robotic arm that receives a transmission of the location of the brain area to be stimulated.

[0035] The position data of the brain region to be stimulated can be position information manually detected by a specialist such as a doctor from the user's MRI image, or can be position information automatically detected using trained artificial intelligence, etc. The position data can be displayed in X, Y, and Z coordinates.

[0036] The mapping module may include an IR LED unit 222 that irradiates light toward the user's brain, and a camera unit 221 that receives reflected light from the light irradiated by the IR LED unit 222 to mark the brain region to be stimulated. In this case, the camera unit 221 may include a 3D camera. The mapping module may guide the magnetic field generating device 100 to a precise stimulation position.

[0037] In addition, the device may further include a communication module 250 that communicates in conjunction with the magnetic field generating device 100, a control unit 260 that controls the above-mentioned configuration, and a power supply module 270 that supplies power to the control unit 260.

[0038] In addition, the cognitive training device 400 according to one embodiment of the present invention can be operated simultaneously or alternately with the magnetic field generating device 100 to stimulate the user's brain, and the cognitive training device 400 can further activate parts of the brain stimulated by the magnetic field generating device 100, or complementarily activate parts of the brain that are insufficiently stimulated by the magnetic field generating device 100, thereby improving the efficiency of dementia treatment.

[0039] The cognitive training device 400 according to one embodiment of the present invention may include a first memory 402 for storing user treatment data such as personal information of a user or cognitive training questions performed by the user or a cognitive training score, and may include a user interface 401 for posing cognitive training questions and allowing the user to provide feedback on their answers thereto.

[0040] The user interface 401 can include various user devices, such as a desktop computer, a notebook computer, a PDA, a tablet PC, etc., and can be a portable PC for the convenience of users.

[0041] The integrated operator 300 according to one embodiment of the present invention is a device that works in conjunction with the cognitive training device 400 or the magnetic field generating device 100 to control the driving time, time interval, frequency, intensity, etc., of the cognitive training device 400 and the magnetic field generating device 100 when they are driven simultaneously or alternately.

[0042] In preparation for loss of user data in the first memory 402, the device may include a second memory 302 that stores the user's treatment history, personal information, etc., and may include a user interface 301 that is configured to allow a user who can control the magnetic stimulation system, such as a doctor or nurse, to manually control or confirm the driving time, time interval, frequency, intensity, etc.

[0043] The second memory 302 can be realized not only as an internal storage device or an external storage device, but also as a DB in the form of a cloud server, so that the user's treatment history and input user information can be automatically linked and stored in the cloud server. In particular, by integrating and storing user data during remote medical treatment, data management can be simplified and user convenience can be improved.

[0044] The user interface 301 can include various user devices, such as a desktop computer, a notebook computer, a PDA, a tablet PC, etc., and can be a portable PC for the convenience of users.

[0045] Magnetic field generating device 100 To receive magnetic stimulation, the user must be in a fixed position and the brain must be stimulated. Therefore, the magnetic field output must be adjusted to below the motor threshold (MT) at which movement occurs in the fingers, etc., and must be maintained close to the motor threshold to increase the efficiency of brain stimulation.

[0046] Conventional magnetic stimulation methods did not check the motor threshold separately or checked the motor threshold by arbitrarily adjusting the intensity at a fixed magnetic field frequency, which caused the user to move at an arbitrary intensity and prevented the user from progressing with the treatment any further, making it impossible to provide personalized magnetic stimulation to each user.

[0047] In particular, since the motor threshold varies depending on the user's race, sex, etc., as well as the user's condition, it is extremely necessary to accurately check the motor threshold immediately before treatment in order to ensure accurate and safe treatment.

[0048] To this end, the magnetic field generating device 100 according to one embodiment of the present invention may include, as shown in Figures 2 and 4, a control unit 110 that determines a corresponding magnetic field taking into account user data including a motor threshold (MT) and a brain region to be stimulated, and a power module 120 that is connected to a coil 160 that generates a magnetic field and supplies power to the coil 160 so that the coil 160 generates the determined magnetic field.

[0049] The control unit 110 may include a magnetic field control module 1101 that adjusts relevant parameters of the magnetic field to control the magnetic field output, and a motor threshold measurement module 1102 that measures the user's motor threshold (MT) using the magnetic field control module 1101.

[0050] In this case, the relevant parameters of the magnetic field may include at least one of frequency, time, period, and strength.

[0051] The motor threshold measurement module 1102 according to one embodiment of the present invention can measure the user's motor threshold by gradually adjusting the magnetic field strength using the magnetic field adjustment module 1101, or, when the magnetic field strength reaches the maximum magnetic field output, can increase the magnetic field frequency by a preset ratio and then further gradually adjust the magnetic field strength to measure the user's motor threshold.

[0052] The motor threshold measurement module 1102 uses the coil 160 to stimulate the motor cortex area of ​​the brain, which is responsible for the motor area of ​​the brain, and then detects changes in hand movement, pulse rate, muscles, or nerves to confirm whether the stimulation is being transmitted to the brain.

[0053] Specifically, the motor threshold of a user varies from person to person, and even for the same user, it varies depending on the day and the condition. In particular, since the motor threshold of Asians is significantly higher than that of Westerners, in a conventional magnetic stimulation device that does not have a control method for measuring an accurate motor threshold, if there is no finger movement in the magnetic field output provided arbitrarily, or if the motor threshold measurement sensor cannot recognize the pulse, muscle, or nerve fluctuation, the user cannot receive magnetic stimulation treatment any more.

[0054] In contrast, the motor threshold measurement module 1102 according to an embodiment of the present invention may first set a magnetic field strength or magnetic field frequency at an intermediate level within the range of possible magnetic field strengths or magnetic field frequencies, and then output the magnetic field. A reference point is set to measure the user's motor threshold.

[0055] As an embodiment of the present invention, the motor threshold measurement sensor may include an ECG sensor, an EMG (Electromyography) sensor, or the like.

[0056] Then, in the first stage, if there is no finger movement, the ECG sensor cannot measure pulse changes, or the EMG sensor cannot measure current changes, the magnetic field frequency is fixed and the magnetic field strength is adjusted by increasing it by a preset ratio (R1) until finger movement occurs, the ECG sensor measures pulse changes, or the EMG sensor measures current changes. If movement is detected, it is determined that the motor threshold at which the motor cortex of the user's brain reacts has been exceeded, and the frequency or strength is reduced by a preset ratio (R2) that is set smaller than the preset ratio (R1) to detect the critical value just before the motor threshold is reached. The critical value becomes the reference value of the magnetic field strength used for brain stimulation.

[0057] That is, if the pulse rate changes or a muscle or nerve is stimulated causing a change in current, there is a motility change, and in the opposite case, there is no motility change.

[0058] On the other hand, if there is no finger movement, the ECG sensor cannot measure pulse changes, or the EMG sensor cannot measure current changes even after increasing the magnetic field strength to its maximum strength, the magnetic field frequency can be increased to improve the magnetic field output. After increasing the magnetic field frequency by a preset ratio (R3), the magnetic field strength returns to the beginning and outputs a medium magnetic field strength, and if no movement is detected, the magnetic field strength is further increased by a preset ratio (R1) until finger movement occurs, the ECG sensor measures pulse changes, or the EMG sensor measures current changes.

[0059] This allows all users to find their own motor threshold (MT), and the critical value just before the motor threshold is set as the reference value for the magnetic field strength used for brain stimulation. Since users who are not mobile can be controlled so that they do not move while receiving brain stimulation, magnetic stimulation can be performed with the maximum magnetic field output for brain stimulation, thereby maximizing the efficiency of treatment while ensuring safety.

[0060] On the other hand, the above-mentioned finger movement detection sensor, ECG sensor, or EMG sensor are merely exemplary embodiments, and the scope of the claims is not limited to the above embodiments. Any motor threshold measurement sensor that detects the mobility of a user can be included in the scope of the claims of the present invention.

[0061] The magnetic field adjustment module 1101 according to an embodiment of the present invention can use received MRI images of a user to determine a magnetic field output based on treatment position information of the MRI images, the distance to the brain region to be stimulated, and the state of the user's brain, including at least one of the morphology, size, and head shape of the user's brain.

[0062] The magnetic field generating device 100 and the brain navigation device 200 communicate and work together via a communication module, so that they can receive MRI images of the user stored in the brain navigation device 200, confirm the distance from the scalp to the brain area to be stimulated, and the morphology of the user's brain taking into account deformations such as how much the user's brain has shrunk, and adjust magnetic field-related parameters to produce a corresponding magnetic field output.

[0063] In particular, by combining an artificial intelligence module with the magnetic field regulation module 1101 and learning magnetic field-related parameters in consideration of the brain shape that differs from person to person, the brain state according to the degree of progression of the disease history, the distance difference according to the brain region to be stimulated, etc., it is possible to immediately output the corresponding magnetic field strength that reflects the above items without having to control and search for the corresponding magnetic fields one by one before magnetic stimulation. In this case, since the magnetic field information can be predicted in advance, the time required to set up the magnetic field generator 100 before treatment can be reduced, more treatment time can be secured, and the efficiency of treatment can be improved.

[0064] In addition, the magnetic field control module 1101 according to one embodiment of the present invention can drive a coil with a magnetic field strength determined by calculating the user's motor threshold measured at a preset ratio depending on the brain region to be stimulated and the user's brain state, thereby performing magnetic field stimulation.

[0065] The reference value, which is the critical value of the motor threshold measured by the motor threshold measurement module 1102, is the magnetic field output that blocks human mobility and maximizes brain stimulation. However, it is necessary to adjust the magnetic field output depending on the brain region to be stimulated, depending on the position difference with the motor cortex of the brain that determines the motor threshold.

[0066] Therefore, using a reference value as a basis, a preset ratio can be set for each brain region, taking into consideration the position and distance of the brain region to be stimulated, and the distance of the brain region to be stimulated due to differences in the shape and size of the user's brain, and the coil can be driven with a magnetic field strength obtained by multiplying the reference value by the above ratio, thereby stimulating each brain region.

[0067] For example, the stimulated brain areas can be six in total, including Broca's area, Wernicke's area, the left and right dorsolateral prefrontal cortex (DLPFC) areas, and the left and right parietal somatosensory association cortex (PSAC).

[0068] At this time, the Broca area has a preset ratio of 0.8 to 1.0 based on a reference value, and if the brain area to be stimulated is the Broca area, a ratio that takes into account the state of the user's brain is selected from the above ratio of 0.8 to 1.0, and the value multiplied by the reference value can be determined as the magnetic field strength.

[0069] Alternatively, the left and right pSACs are located on the dorsal side of the brain and are areas that shrink significantly due to diseases such as dementia, so the ratio can be preset to 1.0 to 1.2, which is a higher ratio than the Broca area, and a ratio that takes into account the user's brain condition can be selected from the above ratios of 1.0 to 1.2, and the value multiplied by the reference value can be determined as the magnetic field strength.

[0070] Alternatively, the left and right DLPFCs may have a preset ratio of 0.9 to 1.1, and the Wernicke's area may have a preset ratio of 0.9 to 1.1. The preset ratios can be determined taking into account the distance from the scalp to each brain area, the brain morphology, etc.

[0071] In particular, the user data including the user's brain state taken into consideration may refer to the brain morphology analyzed from the user's brain MRI images, the distance from the scalp to the brain region to be stimulated, and the skull, etc.

[0072] Therefore, the magnetic field adjustment module 1101 can adjust the magnetic field strength, frequency, etc. according to the brain region to be stimulated and the state of the user's brain, and provide different magnetic stimulation.

[0073] On the other hand, the motor threshold measurement module 1102 and the magnetic field control module 1101 are merely classified according to function, and the motor threshold measurement module 1102 and the magnetic field control module 1101 may be located together in one device, or may be located in different devices and exist within one overall system, or may be located in different devices or systems and send and receive information.

[0074] For example, when there is a separate device for measuring the motor threshold and a separate device for adjusting the magnetic field to perform magnetic field stimulation, if the magnetic field adjustment is performed using the motor threshold measured from the separate device for measuring the motor threshold, this falls within the scope of the present invention.

[0075] In addition, for example, when there is a device for measuring a motor threshold and a device for performing brain therapy using magnetic field stimulation, if the motor threshold measured by the device for measuring the motor threshold is received by the device performing the brain therapy and used to perform brain therapy, this also falls within the scope of the present invention.

[0076] Therefore, as shown in Figures 2 and 4, the magnetic field generating device 100 may include a control unit 110, a power module 120, and a coil 160, and may further include a communication module 130 for communicating with a brain navigation device 200, an integrated operator 300, etc.

[0077] The communication module 130 can include not only wired communication but also wireless communication, and can use Wi-Fi or the like.

[0078] In addition, since temperature control of the device, particularly the coil, is very important for applying a magnetic stimulus to the user stably, the device may further include a cooling module 140 including a temperature monitoring unit 142 that checks the temperature change of the coil 160 and a cooling unit 141 that cools the device when the temperature checked by the temperature monitoring unit 142 exceeds a critical temperature.

[0079] Additionally, a user interface 150 including an input module 151 and an output module 152 may be included to allow the user, as a medical professional, to view or control the magnetic field generating device 100 while the user is receiving medical treatment.

[0080] Meanwhile, the magnetic field generating device 100 may require an administrator's ID and password before performing the magnetic field stimulation, so that only those authorized to treat the user may access the magnetic field generating device 100. Here, the administrator refers to a person who controls the magnetic field generating device 100 to allow the user to receive the magnetic field stimulation method, and the administrator and the user may be the same person or different people.

[0081] Therefore, an administrator who has been granted only the magnetic field stimulation ONLY mode can only view the user's magnetic field stimulation data and cannot view other information such as cognitive training data.

[0082] Brain Navigation Device 200 The brain navigation device 200 can analyze the MRI images of the user to detect the location of the brain region to be stimulated and provide the location to the magnetic field generating device.

[0083] As shown in Figures 3 and 4, the brain navigation device 200 according to one embodiment of the present invention may include an MRI data memory 210 that receives and stores an MRI image of a user and position data of a brain region to be stimulated, and a mapping module 220 that captures an actual head image of the user in real time using a 3D camera and maps the user's brain MRI image and the captured actual head image.

[0084] At this time, according to one embodiment of the present invention, a laser scanner 230 may be included that scans the user's head to detect the head position corresponding to the position of the brain region to be stimulated, and a laser pointer 240 that displays the head position corresponding to the position of the brain region detected by the laser scanner 230.

[0085] The location of magnetic stimulation can be guided by a laser scanner 230 and a laser pointer 240 .

[0086] Alternatively, in another embodiment of the present invention, based on the data mapped by the mapping module 220, the position of the head corresponding to the position of the brain region to be stimulated can be detected by a separate camera, and a robot arm connected to the magnetic field generating device 100 can be moved to the corresponding position.

[0087] Without any separate guide, the robotic arm can immediately acquire the head position corresponding to the location of the brain region to be stimulated and move to the corresponding position.

[0088] The mapping module 220 may include an IR LED unit 222 and a camera unit 221 , and the above-mentioned 3D camera may be included in the camera unit 221 .

[0089] Using the mapping module 220, a separate medical professional can manually search for location data of the brain area to be stimulated on the actual user's head while viewing the mapped image, or the location data of the brain area to be stimulated can be automatically obtained using a laser scanner 230 and a laser pointer 240.

[0090] In addition, the brain navigation device 200 according to an embodiment of the present invention may further include a communication module 250 for communicating with the magnetic field generating device so as to be linked with the brain navigation device.

[0091] According to one embodiment of the present invention, when the laser scanner 230 detects human movement in conjunction with a 3D camera and the laser pointer 240 tracks the changed head position to follow the position of the brain region, when the communication module 250 transmits that there is a misalignment between the position of the coil and the head position tracked by the laser pointer 240, the control unit 110 of the magnetic field generating device 100 can stop driving the coil 160.

[0092] Alternatively, in another embodiment of the present invention, when a robotic arm connected to the magnetic field generating device 100 is used, the control unit 110 of the magnetic field generating device 100 can stop driving the coil 160 when the communication module 250 detects that the robotic arm has moved out of the head position corresponding to the brain region to be stimulated.

[0093] Specifically, it is necessary to detect the position of the brain area to be stimulated in the actual brain of the user sitting in chair 10 so as to receive magnetic stimulation, and position coil 160 near the head corresponding to that position.

[0094] However, it is very difficult to immediately detect the location of the brain area to be stimulated in a real brain, especially if the user is a dementia patient, because the brain is reduced in size and does not have a typical brain shape.

[0095] Therefore, an MRI image of the user's brain is stored in advance in the MRI data memory 210, and the MRI image shows the tip of the nose, the space between the eyebrows, the right ear, and the left ear as reference coordinates, and displays the position of the brain area to be stimulated centered on the reference coordinates, thereby making it possible to create an image in which the treatment position is displayed.

[0096] In addition, the system may further include an image quality improvement module that receives an MRI image of the user's brain and improves the image quality before marking the MRI image. The image processing is performed in advance because the location of the brain area located on the dorsal side of the brain, such as the PSAC, is difficult to confirm from the image in dementia patients whose brains are contracted, although the location is not so difficult for the Broca brain area. This allows for more accurate location detection and improves the efficiency of treatment.

[0097] The mapping module 220 maps the MRI image showing the treatment location to the user's actual head currently being imaged by the 3D camera so that the treatment location is displayed in the image of the actual head, and can guide the magnetic field generating device 100 to the location of the brain area to be stimulated in the actual head.

[0098] Then, using a brain image of an actual person sitting in the treatment chair 10 acquired by a 3D camera, a laser scanner 230 is used to detect the actual position of the head corresponding to the brain area to be stimulated, and the laser pointer 240 can adjust the internal mirror so that the laser is irradiated to the actual position of the head, or the robot arm can automatically move to the position of the head photographed by the camera.

[0099] As a result, the user can determine the position of the coil 160 by matching the alignment reference point of the coil 160 to the point indicated by the laser pointer 240, or the robot arm can automatically move to the position of the coil 160, thereby avoiding the hassle of searching for each brain stimulation area one by one while looking at the screen, thereby improving user convenience and reducing the time required to determine the position of the coil 160, thereby securing more time for treatment, thereby improving treatment efficiency.

[0100] That is, the position of the coil 160 may be moved directly and manually by a user who controls the magnetic field generating device 100, or the position of the coil 160 may be moved using a robot arm.

[0101] When a robot arm is used, position data of the brain region to be stimulated or actual head position coordinates corresponding to the position data of the brain region to be stimulated can be transmitted to the robot arm, and the robot arm can be moved along the x, y, and z axes. At this time, since the robot arm is directly driven by the coordinates, a separate laser pointer 240 for displaying the position of the actual head can be omitted. However, a laser scanner 230 that scans the actual head to obtain actual head position data may be included to check the position movement of the robot arm, or the laser scanner 230 may be omitted and the coordinates may be transmitted directly to the robot arm to move it.

[0102] Therefore, a magnetic stimulation system according to another embodiment of the present invention is a magnetic stimulation system including a magnetic field generating device 100 including a coil 160 that generates a magnetic field, and a brain navigation device 200 that analyzes a user's MRI image to detect the position of the brain region to be stimulated and guides the position of the magnetic field generating device, and may include an MRI data memory 210 that receives and stores the user's MRI image and position data of the brain region to be stimulated, a mapping module 220 that uses a camera to capture an actual head image of the user in real time and maps the user's brain MRI image, on which the position of the brain region to be stimulated is displayed and stored in the MRI data memory, and the actual head image captured in real time, and a robot arm that receives the position coordinates of the brain region to be stimulated in the actual head obtained by the mapping module 220, and moves the coil 160 to a position corresponding to the position coordinates.

[0103] In other words, if the user receiving magnetic field stimulation leaves the treatment and is removed from the magnetic field, the brain navigation device 200 checks the user's condition using a camera, and if the user leaves the treatment position or the position of the head shifts, the brain navigation device 200 uses a laser scanner 230 and a laser pointer 240 to easily return the user's head to the original position corresponding to the coil 160, or the brain navigation device 200 checks the user's condition using a camera and automatically moves the robot arm to the confirmed position, and the magnetic field generating device 100 can be linked to the brain navigation device 200 so as to be turned off until the coil 160 returns to the original position.

[0104] In other words, with the above-mentioned configuration, when the coil is positioned to correspond to the position of the brain area to be stimulated, it can be easily guided to the correct position by the brain navigation device 200 linked to the magnetic stimulation system, and if the user moves during magnetic stimulation, the magnetic stimulation system can be automatically stopped, ensuring safety.

[0105] Cognitive training device 400 According to another embodiment of the present invention, as shown in FIG. 4, the present invention may further include a cognitive training device 400 that is linked to the magnetic field generating device 100 and performs cognitive training by presenting preset questions corresponding to the brain area stimulated by the magnetic field generating device 100, alternately or simultaneously after brain stimulation by the magnetic field generating device 100, so that the brain area stimulated by the magnetic field generating device 100 is activated.

[0106] That is, magnetic field stimulation can be performed using only the magnetic field generating device 100, but by driving the cognitive training device 400 together, the efficiency of treatment can be improved.

[0107] For example, the brain regions performing cognitive functions are six in total, including Broca's area, Wernicke's area, left and right dorsolateral prefrontal cortex (DLPFC) areas, and left and right parietal somatosensory association cortex (PSAC). These are the same as the brain regions in which the brain stimulation is performed, and the cognitive training region and the brain region in which the brain stimulation is performed may be different.

[0108] The Broca area is responsible for syntax, grammar, and word expression, while the Wernicke area is responsible for word meaning and classification. The left and right DLPFs are responsible for action naming, object naming, or spatial memory, while the left and right PSACs are responsible for spatial and orientation tasks. Therefore, to activate the above areas, different types of cognitive training must be performed for each area. The Broca area can be activated by selecting similar sentences, selecting correct or incorrect sentences, and the Wernicke area can be activated by finding the right word or matching words to pictures.

[0109] In addition, the left DLPFC can be activated when memorizing words, matching color of figures, and matching position of figures, while the right DLPFC can be activated when memorizing words, matching action states, or matching names of objects. The left PSAC can be activated when searching for specific letters, and the right PSAC can be activated when searching for hues and figures.

[0110] As an example, the specific character search is a method in which an image is shown in which the specific character "ka" is mixed with similar characters such as "ga" and "ka," and the subject is asked to answer whether "ka" is in the image; however, the specific character may not be in the image.

[0111] As another example, a search for a specific hue and shape is a question in which the question "Is there a blue vertical shape?" is answered by searching for a corresponding hue and shape in an image.

[0112] Therefore, depending on the brain area in question, each brain area can be activated through cognitive training to solve the corresponding type of problem, and questions can be presented such that one type of problem activates one brain area.

[0113] Alternatively, in the case where the magnetic field generating device 100 including the multi-coils 160a, 160b described below magnetically stimulates multiple brain regions simultaneously, the cognitive training device 400 can be configured to solve mixed problem-type cognitive training problems that can stimulate the areas responsible for multiple brain regions at once, thereby enabling the cognitive training device 400 to activate multiple brain regions as well.

[0114] In other words, the magnetic field generating device 100 of the present invention is for outputting a magnetic field to the human brain region to provide electrical stimulation to nerve cells, and while the magnetic field generating device 100 performs the physical stimulation, in order to maximize the efficiency of brain stimulation, the cognitive training device 400 can activate the brain by having it solve problem types in the area that the brain is responsible for.

[0115] Furthermore, according to an embodiment of the present invention, the personalized cognitive training device 400 can be used to perform separate cognitive training at regular intervals, for example, daily.

[0116] The magnetic stimulation by the magnetic field generating device 100 and the cognitive training using the personalized cognitive training device 400 can be performed simultaneously, alternately, or separately, but for the convenience of the user and to reduce time and costs, it is preferable to perform them simultaneously or alternately.

[0117] The cognitive training described above can be performed by the cognitive training device 400 and can be performed simultaneously or alternately with the magnetic field generating device 100, thereby maximizing the efficiency of brain stimulation. This can treat or prevent senile cognitive impairment, such as senile dementia, or can be applied to any user with cognitive impairment, including not only the elderly but also children.

[0118] Meanwhile, the cognitive training device 400 may include a user DB in which user information is recorded, and a cognitive training DB in which cognitive training information is recorded, and may be connected to the DBs via a cloud server. By performing remote medical treatment via the cloud server, treatment can be performed at home. Since visiting a hospital at regular intervals, for example, every day, is inconvenient for the user, this can increase the convenience and accessibility of treatment for the user and improve treatment efficiency.

[0119] The first memory 402 can be realized not only as an internal storage device or an external storage device, but also as a DB in the form of a cloud server, so that the user's treatment history and input user information can be automatically linked and stored in the cloud server. In this case, particularly during remote medical treatment, user data can be integrated and stored, making data management easier and improving user convenience.

[0120] In other words, when the treatment information of a user who has undergone cognitive training at home through remote medical care is stored in the first memory 402, the hospital can immediately check the contents of the first memory 402 via the cloud server, and can also connect to other servers to automatically update the treatment data in the cloud server.

[0121] A specific configuration of the personalized cognitive training device 400 according to an embodiment of the present invention will be described below.

[0122] Thus, a magnetic stimulation system according to an embodiment of the present invention may include a magnetic field generating device 100 and a brain navigation device 200, and may further include a cognitive training device 400.

[0123] Integrated Operator 300 As mentioned above, the magnetic stimulation system of the present invention may further include a cognitive training device 400 .

[0124] In this case, according to another embodiment of the present invention, as shown in FIG. 4, an integrated operator 300 may be further included, which is communicatively connected to the magnetic field generating device 100 and the cognitive training device 400 and drives the magnetic field generating device 100 and the cognitive training device 400 simultaneously or alternately.

[0125] That is, the magnetic field stimulation can be performed using only the magnetic field generating device 100, but the cognitive training device 400 can be operated together to increase the efficiency of treatment, which can be controlled by the integrated operator 300.

[0126] According to another embodiment of the present invention, an integrated operator 300 communicates with the magnetic field generating device 100 or the cognitive training device 400, and the communication can be performed wirelessly such as via WiFi or wired. The integrated operator 300 can determine the time interval between cognitive training and magnetic field stimulation, the duration of cognitive training, the duration of magnetic field stimulation, or related parameters such as magnetic field stimulation intensity and frequency.

[0127] Specifically, the integrated operator 300 can control the cognitive training performed by the cognitive training device 400 and the magnetic stimulation performed by the magnetic field generating device 100 so that they are performed simultaneously or alternately.

[0128] In one embodiment, after magnetic stimulation is performed by the magnetic field generating device 100, cognitive training is performed by the cognitive training device 400 before the effect of the magnetic stimulation falls below a certain value, and after the cognitive training is performed by the cognitive training device 400, the magnetic stimulation is further repeated, so that multiple cognitive training sessions and multiple magnetic stimuli are performed periodically.

[0129] For example, when the magnetic field generating device 100 is a TMS device and the Broca's area is stimulated, the TMS device stimulates 20 pulses for 2 seconds, and after the magnetic stimulation is completed, one set is to solve two "similar sentence finder" problems for 28 seconds, for a total of 20 sets.

[0130] At this time, the integrated operator 300 can control the cognitive training and magnetic stimulation to be performed for 30 seconds per set, the TMS stimulation to be performed for 20 pulses for 2 seconds with a 30-second interval, and the cognitive training to be performed for 28 seconds with 2 problems, i.e., 14 seconds per problem, and the above set can be repeated 20 times.

[0131] The above parameters may vary depending on the brain region to be stimulated, the type of cognitive training problem, user data, etc. For example, under the same conditions as the above example, even if the problem type is simply changed to "select correct or incorrect sentences," the integrated operator 300 can change and set the time interval for TMS stimulation to 33 seconds and the cognitive training to solve two problems for 31 seconds, thereby controlling them differently.

[0132] As another example, if the magnetic field generating device 100 is a TMS device and stimulates Wernicke's area, the TMS device can stimulate the Wernicke's area with 20 pulses for 2 seconds, and after the magnetic stimulation is completed, one set consists of solving four "Find the Correct Word" problems, which are a type of problem that stimulates Wernicke's area for 34 seconds, for 34 seconds, for a total of 20 sets.

[0133] At this time, the integrated operator 300 can control the cognitive training and magnetic stimulation to be performed for 36 seconds each per set, the TMS stimulation to be performed for 20 pulses for 2 seconds at 36-second intervals, and the cognitive training to be performed for 4 problems for 36 seconds, i.e., 8.5 seconds per problem, and the above set can be repeated 20 times.

[0134] In addition, if the user is a cognitively impaired patient, for example a senile dementia patient, the magnetic field or the number of times of cognitive training can be increased taking this into consideration.

[0135] Therefore, the integrated operator 300 can take into consideration the brain area to be stimulated, the type of cognitive training problem to stimulate the above brain area, the user's medical history and personal information, the type of magnetic stimulation, etc., and can thereby adjust the total number of sets performed with the magnetic field generating device 100, the magnetic stimulation time and frequency within one set, the rest time after stimulation, etc., and can adjust the number of cognitive training problems in the cognitive training device 400, the time to solve each problem, the total number of sets performed, etc.

[0136] Meanwhile, the second memory 302 may be realized as a DB in the form of a cloud server, as well as an internal storage device or an external storage device, so that the user's treatment history and input user information can be automatically linked and stored in the cloud server. Based on the above-mentioned training or stimulation results, the cognitive training and magnetic stimulation protocols can be remotely adjusted.

[0137] Therefore, a magnetic stimulation system according to one embodiment of the present invention includes a magnetic field generating device 100 and a brain navigation device 200, and may further include a cognitive training device 400 and an integrated operator 300, which may be controlled to perform cognitive training between a previous magnetic field stimulation and a next magnetic field stimulation, or may be controlled to perform cognitive training simultaneously with the stimulation.

[0138] Meanwhile, FIG. 5 illustrates a flow chart of the motor threshold measurement module 1102 for measuring the motor threshold according to one embodiment of the present invention.

[0139] As shown in FIG. 5, in order to measure the motor threshold (MT), a magnetic field is output to the coil 160 at a preset magnetic field strength using the magnetic field adjustment module 1101 (S501).

[0140] The preset magnetic field strength may, for example, mean a mid-range magnetic field strength at the current magnetic field frequency to define a reference point.

[0141] When the magnetic field is output at a preset strength, if there is no reaction from the fingers, such as a sudden twitch or a flicking of the wrist ("No" in S502), it is determined that the motor threshold has not yet been exceeded, and the magnetic field strength is adjusted to be stronger than before.

[0142] In another embodiment, instead of finger movement in response to magnetic field stimulation, an ECG sensor can be provided to detect changes in pulse rate, or an EMG sensor can be provided to detect changes in electrical current to determine whether the motor cortex of the brain is being stimulated.

[0143] This is an exemplary embodiment, and S502 can be performed by other motor threshold measurement sensors capable of measuring the user's mobility.

[0144] At this time, if the magnetic field is not at its maximum strength ("No" in S503), the magnetic field strength is increased by a preset ratio (R1) and output (S505), and it is possible to continue checking whether the finger reacts (return to S502).

[0145] For example, when the preset ratio R1=n%, where n is 5%, the magnetic field strength is increased by 5% from the initial preset magnetic field strength until the motor threshold is exceeded and a finger reaction occurs.

[0146] During this process, if there is still no reaction from the finger but the magnetic field currently being output is at the maximum magnetic field strength that can be output ("Yes" in S503), the magnetic field frequency is adjusted higher (S504).

[0147] Previously, when a fixed magnetic field frequency was used, if the motor threshold was greater than the amount of stimulation generated by the maximum magnetic field, the user was excluded from further brain stimulation therapy.

[0148] In contrast, according to one embodiment of the present invention, the magnetic field mode is adjusted to increase the magnetic field frequency (S504), and the magnetic field frequency is adjusted and then output at a preset magnetic field strength (return to S501).

[0149] Therefore, S501 to S505 are further repeated, and if there is a finger reaction at a specific magnetic field frequency or strength ("Yes" in S502), it is deemed that the motor threshold has been exceeded, and the motor threshold measurement module 1102 uses the magnetic field adjustment module 1101 to reduce the frequency or strength of the magnetic field strength at a preset ratio (R2) and output it (S506).

[0150] Specifically, when motility is detected, that is, the motor cortex of the user's brain is judged to have exceeded the motor threshold at which the motor cortex reacted, and the frequency or intensity is reduced by a preset ratio (R2) that is set smaller than the preset ratio (R1) to detect the critical value immediately before the motor threshold is reached. This is because brain stimulation must stimulate only the brain area that is to be stimulated, but if the user moves, there is a risk that other areas will be stimulated, so there is no motility and the stimulation intensity must be such that the brain is activated by the brain stimulation.

[0151] For example, when R1 is set to 5%, the magnetic field strength needs to be adjusted more finely to detect the critical value of the motor threshold, so R2 can be set to 1% (m=1) to reduce the magnetic field strength and output it.

[0152] Therefore, if there is a finger reaction ("Yes" in S507), the magnetic field strength is decreased by m%. If there is no further finger reaction ("No" in S507), the magnetic field strength at that time is determined to be the motor threshold (S508). The motor threshold can be defined as the reference value of the magnetic field strength when stimulating the brain.

[0153] This allows a personalized motor threshold detection method to be performed for every user, and motor thresholds that vary depending on race, sex, or the condition of the day can be detected quickly and easily, ensuring safety and maximizing treatment efficiency.

[0154] In addition, although the above examples are limited to finger responses, this is merely an exemplary embodiment and may include embodiments in which a motor threshold measurement sensor is used to confirm a motor threshold response, and does not limit the scope of the claims.

[0155] FIG. 6 illustrates a flow chart for detecting brain location regions to be stimulated according to one embodiment of the present invention.

[0156] As described in FIG. 5, after detecting the user personalized motor threshold, the position of the brain region where the magnetic field stimulation should be performed can be detected using the brain navigation device 200 as shown in FIG.

[0157] The brain navigation device 200 may receive a user MRI image (S601). The received user MRI image may be stored in the MRI data memory 210.

[0158] Next, since the user MRI image has poor image quality and it is difficult to map it with the actual brain image, the image quality of the MRI image can be improved (S602). The brain navigation device 200 can further include an image quality improvement module to improve the image quality of the MRI image marked with the reference coordinates and the brain region coordinates to be stimulated in advance, or after the image quality is improved, the reference coordinates and the treatment position coordinates can be displayed (S603) and stored in the MRI data memory 210.

[0159] In this case, the above-mentioned reference coordinates and the coordinates of the brain region to be stimulated can be set as reference coordinates, as shown in FIG. 7, with the tip of the nose, the space between the eyebrows, the right ear, and the left ear. In the brain region located on the right side, the tip of the nose, the space between the eyebrows, and the right ear can be arranged as reference coordinates, and in the brain region located on the left side, the tip of the nose, the space between the eyebrows, and the left ear can be arranged as reference coordinates.

[0160] When viewed from the right, the position coordinates of the R-PSAC and R-DLPFC can be obtained based on the above reference coordinates, and when viewed from the left, the position coordinates of Broca, Wernicke, L-PSAC, and L-DLPFC can be obtained.

[0161] The above-mentioned reference coordinates can be directly marked by a medical professional capable of reading MRI images to obtain position data, or the position data can be obtained by learning and outputting using an artificial intelligence module.

[0162] Therefore, once a high quality MRI image is acquired, the mapping module 220 can map the MRI image to an actual head image (S604) and match the coordinates of the treatment positions marked on the MRI image with the corresponding coordinates on the actual head image.

[0163] Since the corresponding coordinates are detected in the actual head image, the treatment position of the user's brain where the coil 160 should be located can be determined on the actual user's head by using the laser scanner 230 and the laser pointer 240 or by transmitting the detected coordinates to the robot arm (S605). That is, the determined coordinates can be pointed to by the laser pointer 240 or transmitted to the robot arm so that the magnetic field generating device 100 connected to the robot arm can automatically move.

[0164] In other words, through the above-mentioned flow, the motor threshold for each user and the position of coil 160 corresponding to the brain region to be treated can be detected, and the magnetic field strength can be adjusted based on the motor threshold, allowing each brain region to be magnetically stimulated by coil 160.

[0165] Magnetic field generating device 100 including multiple coils 160a, 160b Meanwhile, the magnetic field generating device 100 as described above includes one coil 160, and when stimulating multiple brain regions, it can stimulate each region in sequence.

[0166] 8, when stimulating multiple brain regions, the magnetic field generating device 100 including the multi-coils 160a and 160b can simultaneously stimulate the brain using the multi-coils 160a and 160b. In this case, preferably, one multi-coil 160a can stimulate at least one region in the right brain region, and the other multi-coil 160b can stimulate at least one region in the left brain region.

[0167] That is, the multi-coils 160a and 160b can magnetically stimulate the brain regions located on the right and left sides of the user at the same time or at a time interval at positions corresponding to the brain regions located on the right and left sides of the user. The multi-coils 160a and 160b can stimulate simultaneously without a time lag or separately with a time lag.

[0168] In this case, one brain area located on the right side and one brain area located on the left side can be stimulated simultaneously, but two or more brain areas located on the right side can also be stimulated simultaneously, or two or more brain areas located on the right side and one brain area located on the left side can also be stimulated at once.

[0169] That is, at least one right-side located brain region or at least one left-side located brain region can be magnetically stimulated simultaneously or with a time interval therebetween.

[0170] In addition, according to one embodiment of the present invention, when the multi-coils 160a, 160b perform magnetic field stimulation simultaneously or at time intervals, the magnetic field frequency, period, time, and strength can be controlled to be the same or different depending on the position of the brain to be stimulated where each of the multi-coils 160a, 160b is located.

[0171] For example, if the contracted brain area is biased toward the Broca region, Broca therapy can be performed continuously while stimulating other brain areas and conducting cognitive training through other channels, and personalized treatment for each individual can be performed by the multi-coils 160a, 160b.

[0172] When stimulating the left and right PSAC regions simultaneously, the strength, frequency, and stimulation period of the output magnetic field can be controlled to be the same for magnetic field stimulation, but when stimulating the right PSAC region and Broca region simultaneously, the strength, frequency, and stimulation period of the output magnetic field can be controlled to be different for magnetic field stimulation. As a result, even if stimulation is performed simultaneously by the multi-coils 160a and 160b, the strength, frequency, and stimulation period can be adjusted differently for each position, so that magnetic field stimulation can be performed to perform personalized treatment for each brain position to be stimulated.

[0173] Therefore, according to an embodiment of the present invention, the magnetic field generating device 100 may include a control unit 110 that determines a corresponding magnetic field in consideration of user data including a motor threshold (MT) and a brain region to be stimulated, and power modules 120a, 120b that are respectively connected to the multi-coils 160a, 160b configured to stimulate a plurality of brain regions simultaneously and supply power to each of the multi-coils 160a, 160b. Since the strength and protocol of the magnetic field are different for each brain region, the power modules 120a, 120b corresponding to each of the multi-coils 160a, 160b may be disposed in the power conversion module 121 in order to output an optimal magnetic field corresponding to each brain region.

[0174] In addition, the control unit 110 may include a magnetic field control module 1101 that controls the magnetic field output by adjusting at least one of the frequency, period, time, and intensity of the magnetic fields of each of the multi-coils 160a and 160b, and a motor threshold measurement module 1102 that measures the motor threshold (MT) of the user using the magnetic field control module.

[0175] The rest of the structure of the magnetic field generator 100 and the configurations of the brain navigation device 200, the cognitive training device 400, and the integrated operator 300 are the same as those described above, except that in order to stimulate multiple brain regions, when the cognitive training device 400 simultaneously trains multiple brain regions for the brain regions simultaneously stimulated by the magnetic field generator 100 during cognitive training, a mixture of questions of predetermined types according to the brain regions may be presented. This allows the integrated operator 300 to perform control taking into account the magnetic field stimulation and cognitive training for multiple brain regions.

[0176] The rest of the description is the same as that described above, and therefore the same description will be omitted to avoid duplication.

[0177] This allows brain stimulation of multiple areas to be performed simultaneously, and more brain stimulation can be performed in the same amount of time, thereby reducing time and costs and increasing treatment efficiency.

[0178] Meanwhile, Fig. 9 shows a flow chart of a magnetic stimulation method according to an embodiment of the present invention, and Fig. 10 shows a flow chart of a motor threshold detection method according to an embodiment of the present invention. The following magnetic stimulation method can be performed with the magnetic field generating device 100 described above.

[0179] Therefore, according to one embodiment of the present invention, as shown in FIG. 9, the method may include a step of measuring a user's motor threshold by adjusting the magnetic field strength or frequency of the coil (S901), a step of positioning the coil in correspondence with the position of the brain region to be stimulated (S902), and a step of driving the coil with magnetic field information determined taking into account the measured user's motor threshold and the brain region to be stimulated (S903) to perform brain stimulation.

[0180] As shown in FIG. 10, the step of measuring the user's motor threshold (S901) includes a step of magnetically stimulating the motor cortex of the user by the coil and checking whether there is finger movement or whether there is motility by an ECG sensor or an EMG sensor (S9011), a step of increasing the magnetic field strength at a preset ratio if there is no finger movement or no change in motility until finger movement or a change in pulse occurs (S9012), and a step of increasing the magnetic field frequency when the magnetic field strength reaches the maximum magnetic field output and increasing the magnetic field frequency in the step S901. 1 and returning to (S9013).

[0181] According to one embodiment of the present invention, in the step S9012, when there is finger movement or change in motility, the magnetic field strength is reduced to a critical value at which the finger does not respond or returns to a previous motility state, and the critical value may be determined as MT.

[0182] In addition, the step of positioning the coil in correspondence with the position of the brain area to be stimulated (S902) is specifically carried out by the brain navigation device 200 mapping the user's MRI image showing the position of the brain area to be stimulated with an actual brain image taken by a 3D camera, acquiring position data of the brain area to be stimulated, and then detecting the distance to the position of the brain area to be stimulated by the laser scanner 230, and displaying the position of the detected brain area by the laser pointer 240.

[0183] Alternatively, according to another embodiment of the present invention, after obtaining the position data of the brain region to be stimulated, it can be transmitted to a robotic arm and the robotic arm can be driven to move to the corresponding position photographed by the 3D camera.

[0184] Therefore, according to one embodiment of the present invention, the step of positioning the coil in a head position corresponding to the position of the brain region to be stimulated (S902) is performed by the brain navigation device 200 by viewing an MRI image of the user on which the position of the brain region to be stimulated is displayed and the camera unit 22.1 the step of mapping an actual head image captured by the laser scanner 230, detecting a head position in the head image captured in real time that corresponds to the position of the brain region to be stimulated displayed in the mapped image by the laser scanner 230, and displaying the detected corresponding head position by the laser pointer 240 or transmitting it to a robot arm.

[0185] According to another embodiment of the present invention, the step of driving the coils to perform brain stimulation (S903) may further include a step of controlling at least one of the frequency, period, time, and intensity of the magnetic fields of the multi-coils 160a, 160b by the magnetic field control module 1101 when driving the multi-coils 160a, 160b to stimulate multiple brain regions simultaneously.

[0186] At this time, when the magnetic field control module 1101 performs magnetic field stimulation on the multi-coils 160a, 160b simultaneously or at time intervals, the magnetic field frequency, period, time, and strength of the magnetic fields of each multi-coil 160a, 160b can be controlled to be the same or different to perform magnetic field stimulation.

[0187] Meanwhile, according to one embodiment of the present invention, the method may further include a step of performing cognitive training by presenting pre-set questions corresponding to the brain regions stimulated by the magnetic field generating device 100 using a separate cognitive training device 400 so that the brain regions stimulated by the magnetic field generating device 100 are activated.

[0188] When outputting a magnetic field, the above-mentioned magnetic field adjustment module 1101 can adjust the frequency in the range of 1 to 200 Hz, the strength in the range of 1 to 10 Tesla, and the time in units of 1 to 200 ms. The above-mentioned ranges are within the output ranges stipulated in the FDA safety regulations, and by adjusting the magnetic field output within the above ranges, it is possible to maintain maximum output efficiency and increase treatment efficiency while ensuring safety.

[0189] Therefore, the magnetic field information output in the step of driving the coil to perform brain stimulation (S903) can be adjusted within the above range.

[0190] Furthermore, when the magnetic field generating device 100 according to an embodiment of the present invention is a TMS device, it can be rTMS that performs repeated magnetic stimulation, and the magnetic field adjustment module 1101 can output theta-burst stimulation (TBS), and can output continuous TBS (cTBS), intermittent TBS (iTBS), etc. Theta-burst stimulation is a very high frequency stimulation performed within a short period of time, and can be performed within the above-mentioned range at a frequency of 50 Hz with a time interval of 200 ms.

[0191] The magnetic field adjustment module 1101 can adjust the stimulation frequency of the rTMS to maintain optimal brain region stimulation efficiency.

[0192] Therefore, the present invention can stimulate the brain with 1500 pulses per day by the above-mentioned magnetic stimulation method, and can stimulate three brain regions at once when using the multi-coil 160. The number of pulses for brain stimulation follows the TMS clinical trial and safety guidance.

[0193] Meanwhile, according to yet another embodiment of the present invention, a magnetic stimulation device may include a processor configured to execute the steps of the magnetic stimulation method described above, and a memory that stores data on a cloud server that has been generated by driving a coil with the user's motor threshold or determined magnetic field information to perform brain stimulation.

[0194] The magnetic stimulation device generates a magnetic field to perform magnetic stimulation, and user data including information such as the user's gender, race, and age, as well as information on the magnetic stimulation performed by the user, are all stored in memory, which can be used to control the magnetic stimulation of the user later or as reference data for other users who have the same user information. At this time, the memory can be used as a cloud server for remote medical treatment.

[0195] The present invention may further include a transceiver for remotely communicating with the processor so that the processor executes the steps of the magnetic stimulation method. When the processor executes the steps of the magnetic stimulation method, a robot arm is driven correspondingly to execute the magnetic stimulation method, and the robot arm can be remotely controlled by the transceiver so that the robot arm is remotely driven.

[0196] According to yet another embodiment of the present invention, a remote medical treatment system may include a magnetic stimulation system including at least one of a magnetic field generating device 100 that performs magnetic field stimulation, a brain navigation device 200 that guides the position of the magnetic field generating device 100, and a cognitive training device 400 that performs cognitive training simultaneously or alternately with the magnetic field generating device 100, a cloud server that stores user usage results of the magnetic stimulation system, and an administrator terminal that is connected to the cloud server after security procedures, checks the user usage results, and remotely controls the magnetic field output or cognitive training of the magnetic stimulation system.

[0197] The magnetic stimulation system may be a magnetic stimulation system according to any of the above-described embodiments, and the administrator terminal may refer to an administrator terminal having an ID and password that allows access to the cloud server, and the administrator terminal may refer to a user interface such as a computer installed in a hospital.

[0198] According to yet another embodiment of the present invention, the administrator terminal can control at least one of the frequency, period, and time of the magnetic field generated by the magnetic field generating device and the period and time for solving the cognitive training problem performed by the cognitive training device, taking into consideration at least one of the brain area stimulated by the magnetic stimulation system, user data, and the type of cognitive training problem performed by the cognitive training device, and can update the control content to the cloud server in real time. This makes it possible to integrate and manage the user's treatment history, thereby facilitating management and creating a data database.

[0199] The specific cloud server update contents will be described below.

[0200] Meanwhile, when stimulating the user's brain with the magnetic field generator 100 of the magnetic stimulation system, in addition to direct stimulation by the magnetic field, brain stimulation by training with a cognitive training device can be provided to the user's brain. After stimulation with the magnetic field generator 100, cognitive training for training the stimulated brain before activity due to the stimulation decreases can be performed to maximize the efficiency of brain stimulation.

[0201] The personalized cognitive training device 400 according to one embodiment of the present invention can conduct cognitive training immediately after brain stimulation with the magnetic field generating device 100, before activity due to brain stimulation falls below a certain value, or simultaneously with brain stimulation with the magnetic field generating device 100.

[0202] Alternatively, while performing stimulation multiple times at a constant cycle using the magnetic field generating device 100, cognitive training using the personalized cognitive training device 400 can be performed multiple times at a constant cycle in alternating fashion.

[0203] In other words, when the magnetic field generating device 100 is used, the personalized cognitive training device 400 can be further used to complement and maximize the efficiency of the user's brain stimulation, thereby improving the efficiency of the user's treatment, and reducing the number of times the user needs to visit a specific location to receive brain stimulation, thereby improving user convenience.

[0204] Specifically, therefore, FIG. 11 illustrates a detailed configuration of a personalized cognitive training device 400 according to an embodiment of the present invention.

[0205] As shown in FIG. 11, the personalized cognitive training device for performing a plurality of cognitive trainings includes a content storage unit 410 for classifying and storing content used for question setting by level or item, a question setting unit 420 for setting questions for the corresponding cognitive training in consideration of a brain area activated by the cognitive training and user data, a score determination unit 430 for determining whether or not to maintain the range of the score or the score acquired for the question set by the question setting unit 420, and the question modification unit 440 for changing the level of the question or the pool of questions based on the result of the score determination unit 430. The question modification unit 440 includes a level adjustment module for adjusting the level of the question so that a preset optimal score range is maintained. 4401 and a pool conversion module for changing the stage or item of the content storage unit 410 so as to change the pool of questions when the cognitive training result score of the current round is still the same as the previous cognitive training result score even after the difficulty of the questions is changed. 4402 and

[0206] Specifically, the level adjustment module 4401 However, when the difficulty of the problem is changed so that the cognitive training result score of the next round is within a preset optimal score range, or when the cognitive training result score of the current round is still maintained the same as the previous cognitive training result score even after the difficulty of the problem is changed so that the cognitive training result score of the next round is within a preset optimal score range, 4402 may change the question type for the next round.

[0207] According to an embodiment of the present invention, the preset optimal score range is preset by the user and may be a score range of 85 points to 95 points. It is important that the cognitive training device 400 continues to stimulate the user's brain.100 If points are continually given, the user will find the correct answer too easy, which will decrease concentration, make the user feel sleepy, and decrease the efficiency of brain stimulation. Conversely, if a low score of 40 to 50 points is given, the questions will be too difficult, which will decrease the user's interest, decrease concentration, and decrease the efficiency of brain stimulation. Therefore, in order to continuously maintain the brain activation state, a score range of 85 to 95 points can be set, but this is an exemplary embodiment and the scope of the claims is not limited thereby.

[0208] Therefore, the question modification unit 440 can modify the difficulty of questions or the question pool in consideration of the user's cognitive training result score output by the score determination unit 430 so as to maintain a preset optimal score range.

[0209] In addition, if the difficulty level or question pool is changed in consideration of the user's cognitive training result score, the difficulty level or question pool can be adjusted to provide questions for improving appropriate brain function according to the degree of progression of the user's dementia and the state of the brain, but questions based on user data such as the user's personal information or history cannot be provided. If questions are provided without considering the user's data, there may be words or sentences that the user does not understand, regardless of the progression of dementia, and in this case, the question will also be treated as an incorrect answer, and the user may receive incorrect feedback on the progression of dementia.

[0210] Therefore, when determining the question difficulty or question pool for the next round, the question type can be changed to another type taking into consideration user data, where the user data can include at least one of the user's educational background, language fluent, gender, residential area history, and occupational history.

[0211] That is, the question setting unit 420 determines the type of question depending on the brain area to be activated, and the level adjustment module of the question changing unit 440 4401 The score determination unit 430 adjusts the difficulty of the questions in consideration of the user's cognitive training result score, and the pool conversion module 440 4402If the user's result score is not affected even after the difficulty of the question is adjusted, the level or item of the content storage unit 410 may be changed to change the question type to another type.

[0212] 12 to 14 are schematic diagrams showing the configuration of a content storage unit 410 according to an embodiment of the present invention, and show a structure in which the content storage unit 410 classifies and stores words.

[0213] As shown in FIG. 12, the content storage unit 410 according to one embodiment of the present invention may include a cognitive training database DB including a word module 4101 including words to be presented as word questions, a sentence structure module 4102 that classifies and stores words according to sentence structures so that they can be presented as sentence questions, and a user data module 4103 that stores user data including at least one of a user's personal information and a user's treatment information.

[0214] The word module 4101 is a DB in which words representing things and actions are stored, and can provide words to be used by the sentence structure module 4102 to generate sentences to activate Broca's function, or words to be used in finding the correct word to activate Wernicke's function, matching words to pictures, or matching action or thing names to activate the right DLFP.

[0215] In addition, the sentence structure module 4102 can classify and store words into subjects, predicates, objects, complements, or functional words, and extract words from each of the classified items when generating a sentence.

[0216] In particular, the sentence structure module 4102 according to an embodiment of the present invention configures modules with sentence structures corresponding to Korean sentences in accordance with the Korean language, but can also configure modules with sentence structures corresponding to sentences in other languages, such as English, Japanese, and Chinese.

[0217] In addition, the user data module 4103 may store user history information including at least one of the user's educational background, language, gender, region, and occupation, or may store user treatment information including the user's cognitive training content or cognitive training result score, etc.

[0218] Thus, the user data module 4103 may include a user medical information DB that stores user history information and user medical information.

[0219] For example, if a user is fluent in multiple languages, for example, if the user is fluent in both Korean and English, multiple sentence structure modules 4102 can be provided, including not only a sentence structure module that corresponds to Korean sentences, but also a sentence structure module that corresponds to English sentences, taking into account the user data, and the difficulty level can be adjusted or the question pool can be changed using the above languages.

[0220] Alternatively, since the user's educational background may affect the knowledge the user possesses, if the user has graduated from graduate school, the vocabulary used in graduate school may also be included in the word module 4101 .

[0221] Alternatively, since experiences that can be experienced vary depending on gender, the terminology that can be acquired from those experiences can be taken into consideration and reflected in the word module 4101.

[0222] Alternatively, based on the user's residence history, a user who has only lived in Seoul may not understand words in the local dialect, regardless of dementia, but a user who has lived in an area where dialects are used may have words used only in the local dialect included in the word module 4101 and may use these for cognitive training.

[0223] Therefore, the content storage unit 410 structures and stores the words and user data used in posing questions based on the above-mentioned classification, and the word module 4101 and the sentence structure module 4102 can extract words and sentences taking into account the user data transmitted from the user data module 4103, and can pose personalized questions for each user that can continuously stimulate the user's brain.

[0224] In particular, among the types of questions that correspond to the above brain regions, matching words to pictures, matching action names, and matching object names are areas that are particularly susceptible to the influence of the environment, so it is extremely important to create questions that take user data into consideration.

[0225] In addition, the problem difficulty and problem pool used in cognitive training are associated with user history information and stored in the user data module 4103. Therefore, once user data is accumulated, it can be used as big data to reduce the time and cost required to set or change personalized questions for the user, and the optimal score range that provides the most efficient brain stimulation can be derived using the user data.

[0226] Specifically, as shown in FIG. 13 and FIG. 14, the content storage unit 410 according to an embodiment of the present invention classifies and stores the words by stage or by item within one stage, where the stage includes stages 1 to n, and n is a positive integer of 2 or more.

[0227] According to an embodiment of the present invention, the first level of the content storage unit 410 includes noun items and verb items, and the higher the level number, the more sub-concept words that are sub-divided into the above items can be included.

[0228] As shown in Fig. 13, the content storage unit 410 can store words by structuring them into the first to fourth stages (n = 4). The first stage includes one noun (thing) item, and the second stage can include living items and inanimate items, which are sub-concepts of the noun (thing) item.

[0229] The third level may also include plant and animal items, which are subdivisions of the living items in the second level, and clothing and tool items, which are subdivisions of the inanimate items in the second level.

[0230] The fourth level may include subdivisions of plant items from the third level, such as grass and flower items, subdivisions of animal items, such as canine and feline items, and subdivisions of clothing items from the third level, such as trousers, shirts, and socks.

[0231] For example, in the third stage, the question setting unit 420 may show a picture of a millstone and ask what the clothing and tool are, but in the fourth stage, the question setting unit 420 may show a millstone and a sickle that embody the tools from the third stage and ask what they are.

[0232] Although n is a number equal to or greater than 2, the level that is actually given as a question is the level with the largest number or the level just before the largest number, and the remaining levels can be used to structure the levels and items and classify the question pool.

[0233] According to one embodiment of the present invention, if the average score remains constant for multiple consecutive rounds outside the optimal range set by the user even after adjusting the difficulty of the questions, the stage or item of the content storage unit 410 can be changed so that the question pool is changed.

[0234] As a specific embodiment, it is assumed that the content storage unit 410 shown in Fig. 13 is set to n=5 and further includes a fifth stage. When the fifth stage includes Phlox, Bombyx mori, Tatsutasou, Sillago japonica, Forsythia, etc., which are subdivisions of the flower items described in the fourth stage, if user 1 has lived in Gangnam-gu, Seoul, and has never been exposed to flowers throughout his or her life, user 1 would not know whether Phlox, Bombyx mori, or Tatsutasou are correct words or words that match the pictures, regardless of dementia.

[0235] In contrast, if User 2 is a botanist by profession, even if User 2 has lived in Gangnam-gu, Seoul all his or her life, User 2 should be able to know that the correct words are Moss Phlox, Grass Oleander, Tatsutasou, and White Rose, and should be able to look at a photo and select the word that matches the photo. If User 2's dementia becomes severe and he or she is no longer able to select the above words, User 2 will be able to receive accurate feedback on the progression of his or her dementia.

[0236] In other words, even if the same questions are asked at the same stage, the brain activation process in which the user thinks and arrives at the answer may or may not be accomplished depending on the user's data.

[0237] Therefore, if user 1 continues to receive scores that are lower than the preset optimal score range, the pool conversion module 4402 may determine that the item does not have the discernment to activate the user 1's brain, and may downgrade the item from the fifth stage to the fourth stage in the content storage unit 410, and then change the item from a flower item to a canine item.

[0238] Or, if user 1 continues to receive scores significantly lower than the preset optimal score range, the pool conversion module 4402determines that the item in question and items close to it do not have the discernment to activate the user 1's brain, and may lower the level of the content storage unit 410 by two levels, from level 5 to level 3, and then change the item from a level 3 plant item, which is a higher concept of a flower item, to a level 3 tool item.

[0239] In contrast, if User 2 continues to solve the flower questions in the fourth stage and receive scores higher than the preset optimal score range, the questions may be too easy, causing a decrease in concentration and a decrease in the level of brain activation, so the stage can be increased and questions on the moss phlox, bamboo oleander, water lily, and white laurel can be presented in the fifth stage.

[0240] As shown in Fig. 14, the content storage unit 410 can store words structured into first to fourth stages (n = 4). The first stage includes one verb (action) item, and the second stage can include behavioral items, psychological items, and perception items, which are sub-concepts of the verb (action) item.

[0241] In addition, the third stage can include transportation and play items that are subdivisions of the behavioral items in the second stage, anger, sadness, and joy items that are subdivisions of the psychological items in the second stage, and sensory and cognitive items that are subdivisions of the perceptual items.

[0242] The fourth stage can include items such as "too long" and "long ago" which are subdivisions of the movement items from the third stage, items such as "sad" and "crying" which are subdivisions of the sadness items, and items such as "see," "hear," and "become" which are subdivisions of the sensory items from the third stage.

[0243] In one specific embodiment, if the user data of user 3 is an office worker, male, Seoul, university graduate, when looking at "naru" in the fourth stage, it is unclear whether it means "naru" meaning to have a new status or position, or "yoruru" which is a Gyeongsang dialect meaning to have too much work. For example, if the above "naru" has the latter meaning, user 3 can see the sentence "He has too much work" and select it as an incorrect sentence, but this will be an incorrect answer.

[0244] Therefore, if the incorrect answers are repeated and the average score remains constant for multiple rounds beyond the optimal range set by the user even after adjusting the difficulty of the questions, the pool conversion module 4402 can lower the level of the content storage unit 410 to the third level so that the question pool is changed, and then change the item to a moving item of the third level and ask the question.

[0245] Therefore, the pool conversion module 4402 can change the question type to another type by considering the user data when determining the question pool.

[0246] According to one embodiment of the present invention, the pool conversion module 4402 may change the items by lowering the level of the word module so that a word of a higher concept is presented when the result score is maintained below a preset optimal score range, and may change the items by raising the level of the word module so that a word of a lower concept is presented when the result score is maintained above a preset optimal score range.

[0247] Alternatively, if the result score showing a large difference from the preset optimum score range is maintained, the content storage unit 410 may change the item by lowering or raising the level by several levels.

[0248] Meanwhile, the sentence structure module 4102 includes subject items, complement items, object items, and predicate items, and may further include functional word items.

[0249] In order to activate Broca's area, similar "sentences" must be presented, and "correct or incorrect sentences" must be presented. The conditions for forming a sentence must include a predicate, and the predicate can be added with a subject, or with a subject and an object, or with a subject and a complement, or with a subject, object, and complement.

[0250] The question setting unit 420 can change the question type or adjust the difficulty by adding or deleting the subject, object, and complement, which are nominal words that come before the predicate, and can form correct or incorrect sentences by adjusting the presence or absence and position of the predicate.

[0251] As an example, the functional word items may include nouns, modifiers, relative words such as particles, conjunctions, predicates, operational words, and independent words such as interjections.

[0252] Meanwhile, the level adjustment module 4401 according to an embodiment of the present invention can reduce the difficulty of questions or, if the current cognitive training round is the first round, prioritize items related to the user data transmitted from the user data module 4103 and present questions from a question pool related to the input user data.

[0253] As mentioned above, items related to user data are words that the user has encountered before and may affect the difficulty level. Therefore, in the first round of cognitive training without previous data, the difficulty level can be reduced or items related to user data can be given higher priority, allowing the user to solve the problem more easily.

[0254] Furthermore, the level adjustment module 4401 can adjust the level of difficulty of a problem in which a particular character is to be found by, for example, making only the particular character larger or reducing the total number of characters.

[0255] Alternatively, the level adjustment module 4401 can reduce the number of syllables in a word or the number of words that make up a sentence to lower the difficulty of sentence and word related questions such as selecting similar sentences, selecting correct or incorrect sentences, or finding the correct word or matching a word to a picture.

[0256] When adjusting the difficulty level, the difficulty level may be adjusted by one level depending on the result score, but if the result score is far outside the optimal score range, the difficulty level may be adjusted by multiple levels.

[0257] In a personalized cognitive training device for performing multiple cognitive training exercises according to one embodiment of the present invention, the method may include the steps of inputting user data into the device and presenting predetermined types of questions depending on the brain area to be trained, determining a cognitive training result score based on feedback provided by the user for the presented questions, and determining the question difficulty or question pool for the next round based on the cognitive training result score of the current round.

[0258] In this case, the step of determining the problem difficulty or problem pool of the next round may change the problem difficulty so that the cognitive training result score of the next round is within a preset optimal score range, or may change the problem type of the next round when the cognitive training result score of the current round is still maintained the same as the previous cognitive training result score even after changing the problem difficulty.

[0259] Here, a "round" refers to a cognitive training routine that is repeated at a certain interval and can be preset by the user. For example, if a "round" is defined on a weekly basis, a first week round, a second week round, ..., an Nth week round can be performed.

[0260] 15 is a flow chart of a personalized cognitive training method according to an embodiment of the present invention, in which user data is input to the personalized cognitive training device 400 (S701), a treatment location is selected from among brain regions according to a preset schedule (S702), and a preset cognitive training type corresponding to the brain region is output (S703), which is the same as the cognitive training type corresponding to the brain region described above.

[0261] According to an embodiment of the present invention, when the unit of the round is one week, the personalized cognitive training method for performing multiple cognitive training sessions may perform training sessions one week at a time for a total of four weeks.

[0262] At this time, if it is the first week of cognitive training ("Yes" in S704), since there is no previous cognitive training result score, the user data entered in the device can be used to present questions related to the user data. Also, the difficulty level can be set to level 0, making it the easiest question.

[0263] On the other hand, if it is not the first weekly cognitive training ("No" in S704), the question pool and difficulty level can be determined using the user data entered into the device and the cognitive training result scores of the previous round (S705).

[0264] Cognitive training is started according to the determined type of cognitive training and the difficulty and pool of cognitive training questions (S706). When the cognitive training is completed after being performed according to a preset method (S707), the results of the cognitive training can be transmitted to the user (S708).

[0265] When the cognitive training for the preset period of one week is completed ('Yes' in S709), the average score of the cognitive training result during the preset period can be calculated and the average score of the cognitive training result can be stored (S710). At this time, the average result can be stored in the user treatment information DB, which can be included in the user data module 4103.

[0266] Meanwhile, the user data input in S701 can also be stored in the user treatment information DB (S711).

[0267] Meanwhile, in S703, according to another embodiment of the present invention, when multiple brain regions are trained simultaneously during each cognitive training, questions that are a mixture of predetermined types of questions according to the brain regions may be presented, i.e., multiple brain regions may be trained simultaneously, and each brain region may be trained separately, thereby varying the types of questions.

[0268] 16-19 show a flow chart for adjusting the level or question pool of a personalized cognitive training method according to one embodiment of the present invention.

[0269] After performing cognitive training in FIG. 15 and obtaining and storing the average result score (S710), as shown in FIG. 16, the level adjustment module 4401 can check the average result score stored in the user treatment information DB and adjust the difficulty of the questions in the next round based on the average result score.

[0270] For example, assume that the round is on a weekly basis and the optimal score range preset by the user is between 85 and 95 points.

[0271] The level adjustment module 4401 checks whether the average score stored in the user treatment information DB is within an optimal score range.

[0272] Specifically, if the average score is less than 85 points (S801, "Yes"), the level adjustment module 4401 decreases the difficulty of the questions, and if the average score is more than 95 points (S802, "Yes"), the level adjustment module 4401 increases the difficulty of the questions. On the other hand, if the average score is between 85 points and 95 points, which is the optimal score range (S801, "No" & S802, "No"), the level adjustment module 4401 can maintain the difficulty.

[0273] That is, the level adjustment module 4401 adjusts the difficulty of the questions based on the average score (S803).

[0274] Thereafter, the next weekly question is set according to the determined question difficulty level (S804), and the set question can be stored in the cognitive training DB.

[0275] As shown in FIG. 17, after the level adjustment module 4401 adjusts the level based on the current average score, the pool conversion module 4402 can change the question pool according to the degree of change between the previous weekly average score and the current weekly average score.

[0276] As shown in FIG. 17, after checking the average score for N weeks, steps S901 to S903 are in a different order from steps S801 to S803 shown in FIG. 16, but are the same steps in that they check whether the average score is within a preset optimal score range.

[0277] After the level adjustment module 4401 determines the difficulty level for the next round (week N+1) (S903), the average scores for week N-1 and week N are compared (S904), and the pool conversion module 4402 can decide whether to change the question pool.

[0278] The average scores for week N-1 and week N are compared (S904), and if the average score is maintained (Yes in S906), the question pool can be changed (S907). If the difficulty level is changed and there is a change in the average score (No in S906), the question pool can be maintained (S908).

[0279] However, if N is 2 or more ("No" in S905), the above process can be carried out. If N=1 and it corresponds to the first week ("Yes" in S905), since there is no average score for the previous week, questions for the second week (N+1 week) can be immediately posed and stored without changing the question pool.

[0280] The question pool change flow shown in FIG. 17 is specifically shown in FIG. 18, which shows how the pool conversion module 4402 adjusts the question pool based on the average score of the cognitive training results.

[0281] As shown in FIG. 18, the average scores for the N-1th week and the Nth week are compared (S904), and if the average score remains below 85 points ("Yes" in S4001), the word concept level in the content storage unit 410 is reduced or the items are changed.

[0282] Also, if the average score remains above 95 points ("Yes" in S4002), the word concept level of the content storage unit 410 is increased or the item is changed.

[0283] In other words, if the average score is maintained below 85 points or above 95 points, the question pool is changed (S907), and if the average score is maintained within the pre-set optimal range of 85 points to 95 points, the question pool can be maintained (S908).

[0284] The pool conversion module 4402 determines the question pool through the above process, and stores it in the cognitive training DB, which can then be used in the next round of cognitive training.

[0285] Therefore, in a personalized cognitive training device for performing multiple cognitive training exercises according to one embodiment of the present invention, user data is input into the device, predetermined types of questions are posed depending on the brain area to be trained, a cognitive training result score is determined based on the answers provided by the user to the posed questions, and the question difficulty is changed based on the cognitive training result score of the current round so that the cognitive training result score of the next round is within a predetermined optimal score range, or the question type of the next round can be changed when the cognitive training result score of the current round is still maintained the same as the previous cognitive training result score even after the question difficulty is changed.

[0286] Specifically, according to an embodiment of the present invention, if the cognitive training result score of the previous round and the cognitive training result score of the current round with the changed question difficulty are both below a preset optimal score range, questions are set from a question pool that is highly relevant to the user data, and if both exceed the preset optimal score range, questions are set from a question pool that is less relevant to the user data. The question pool and difficulty are determined taking into account the user data.

[0287] FIG. 19 shows a flow chart for adjusting the level and question pool taking into account user data in a personalized cognitive training method according to an embodiment of the present invention.

[0288] According to an embodiment of the present invention, when determining the question pool in the step of determining the question difficulty or question pool of the next round based on the cognitive training result score of the current round, the question type may be changed to another type taking into account the user data.

[0289] At this time, according to an embodiment of the present invention, the user data may include at least one of the user's educational background, language proficiency, gender, residential area history, and occupation history.

[0290] That is, when the pool conversion module 4402 determines the question pool, it can determine the pool taking into account user data.

[0291] Specifically, as shown in FIG. 19, a user treatment data DB included in a user data module 4103 can check input user data (S1101).

[0292] If it is not the 1st week ("No" in S1102), the average scores for week N-1 and week N are compared (S1105). If the resulting average score is less than 85 points ("No" in S1106), the question pool can be changed to one with increased relevance to user data, and if the resulting average score is more than 95 points ("Yes" in S1106 and "No" in 1107), the question pool can be changed to one with decreased relevance to user data (S907).

[0293] On the other hand, if the average result score is between 85 and 95, the question pool can be maintained regardless of user data.

[0294] That is, when changing the question pool, it is not only possible to simply change to another question type, but also possible to change the question pool by determining the priority of the question pool in consideration of user data.

[0295] The question pool is modified to take user data into account, since the user has more information on topics related to the user data and can more easily provide answers to questions.

[0296] On the other hand, if the cognitive training is for one week ('Yes' in S1102), since there is no previous weekly average score, in order to conduct a very easy level of cognitive training to evaluate the user's level, a high priority is given to the problem types that are related to the user data (S1103), level 0 problems are asked from the corresponding problem pool (S1104), and lower level problems are asked from the problem pool that is highly relevant to the user.

[0297] This allows users to easily answer questions by lowering the level of related items to user data, as well as changing the question type, and allows users to check their status when conducting cognitive training for the first time.

[0298] Therefore, according to another embodiment of the present invention, in the step of changing the step or item of the content storage unit 410, the priority for question presentation of the item related to the user data can be adjusted using the user data inputted to the device 400 and the cognitive training result score of the current round.

[0299] Specifically, according to another embodiment of the present invention, the levels of the content storage unit 410 may include words with sub-concepts that subdivide the item as the number increases, and if the average score is continuously maintained for multiple rounds below an optimal range set by the user, the level may be lowered to give priority to items with a high correlation with the user data, and if the average score is continuously maintained for multiple rounds above an optimal range set by the user, the level may be raised to give priority to items with a low correlation with the user data.

[0300] In addition, if the current cognitive training round is the first round, the question pool is determined by giving priority to items that are highly correlated with the above user data, and the question pool for the next round is also maintained to be the same as the question pool for the first round, and the difficulty level of the questions for the current cognitive training can be set to the minimum level.

[0301] This solves the problem that if the cognitive training result score of a user who undergoes cognitive training remains very low or very high even when the difficulty of the questions is continuously adjusted and brain stimulation is not performed properly, the user is excluded from dementia treatment without undergoing further cognitive training.

[0302] The personalized cognitive training of the present invention allows users to undergo cognitive training that matches their own history and treatment information, so that any user can effectively receive dementia treatment through cognitive training questions that match them, and the treatment effects can be improved even for existing users.

[0303] According to one embodiment of the present invention, the brain region to be trained is at least one of Broca's, Wernicke's, L-DLPFC, R-DLPFC, L-PSAC, and R-PSAC, and during each cognitive training session, a mixture of types of questions predetermined according to the brain region may be presented.

[0304] Also, during each cognitive training, if multiple brain regions are trained simultaneously, new types of questions can be presented that are a mixture of pre-determined types.

[0305] According to one embodiment of the present invention, a personalized cognitive training device 400 including a content storage unit 410 in which words used in cognitive training are classified and stored by stages or by items within one stage, the stages including 1 to n stages, where n is a positive integer of 2 or more, may include the steps of: calculating an average score based on answers entered for a plurality of types of questions presented to activate each brain area for a preset period for each round; and changing the stages or items of the content storage unit 410 so that the question pool is changed if the average score remains constant continuously for a plurality of rounds outside an optimal range set by a user even after adjusting the difficulty of the questions.

[0306] According to an embodiment of the present invention, the content storage unit 410 may include noun items and verb items in the first stage, and the higher the stage number, the more sub-concept words the items may be divided into.

[0307] According to an embodiment of the present invention, if the current cognitive training round is the first round, questions may be set from a question pool related to the input user data, in order to set questions from items highly relevant to the user and adjust the difficulty level to a low level.

[0308] In addition, before the pool conversion module 4402 changes the pool, the level adjustment module 4401 can change the level to adjust the difficulty of the problem, and according to one embodiment of the present invention, the number of words, sentence length, number of hues, or number of shapes extracted from the DB can be adjusted depending on the difficulty.

[0309] Furthermore, the level adjustment module 4401 can reduce the difficulty of the questions or, if the current cognitive training round is the first round, prioritize items related to the user data transmitted from the user data module 4103 and present questions from a question pool related to the input user data.

[0310] Specifically, the level adjustment module 4401 according to one embodiment of the present invention can maintain the difficulty of the questions in the next round when the cognitive training result score of the current round is within a preset optimal score range, can decrease the difficulty of the questions in the next round when the cognitive training result score of the current round is below the preset optimal score range, and can increase the difficulty of the questions when the cognitive training result score of the current round is above the preset optimal score range.

[0311] Meanwhile, according to one embodiment of the present invention, an input unit 450 for receiving an answer input by a user to a question and an output unit 460 for outputting a question so that the question is provided to the user may be included, and the input unit 450 and the output unit 460 may be included in the user interface 401 of FIGS. 4 and 8.

[0312] The output unit 460 may refer to a display module, and the input unit 450 may refer to an input interface such as a tablet PC, a notebook computer, or a desktop computer that can receive answers input by a user and provide them to the control unit 470, or a device including a TTS (Text To Speech) program that automatically stores the user's voice answers in a computer.

[0313] Alternatively, according to another embodiment of the present invention, the questions posed are provided to the user via the output unit 460, but the user can directly input the answers to the questions in the form of direct responses to medical staff such as nurses. This is because users with dementia have poor motor skills, and the answers may not be accurately accepted if they are processed mechanically.

[0314] In addition, according to a specific embodiment of the present invention, the word module 4101 includes at least one item of a word, a color, a figure, and a photo, the sentence structure module 4102 includes at least one item of a subject, a predicate, an object, and a complement, and the user data module 4103 includes at least one item of the user's educational background, language, gender, region, and occupation.

[0315] In other words, the hues, shapes, and photos stored in the word module 4101 can also be set according to the level of difficulty. For example, the number of hues or shapes can be adjusted, or, taking into account the user data module 4103, photos related to foreign countries can be set as questions to lower the level of difficulty since users who have lived abroad are familiar with foreign cultures.

[0316] In addition, the question setting unit 420 can use at least one of the brain area to be stimulated, the difficulty level determined by the level adjustment module 4401, and the pool converted by the pool conversion module 4402, and output the corresponding type of question using the information stored in the word module 4101, sentence structure module 4102, and user data module 4103.

[0317] This allows personalized cognitive training to be provided to all users without excluding users from dementia treatment, and the effectiveness of dementia treatment can be improved by stimulating brain regions more accurately and efficiently through cognitive training questions that reflect user data such as each user's history. In addition, the accuracy of brain region stimulation can be further improved by adjusting not only the difficulty level but also the question pool.

[0318] In addition, the database can be easily expanded because the words used in the questions are classified and stored according to stages or items. As time passes, when new terms or terms referring to new items appear and new words need to be added, the words can be easily added to the existing DB, ensuring scalability.

[0319] In particular, the content storage unit 410 of the present invention can be continuously updated by receiving not only a directly collected word DB but also a word DB collected by a third party such as Google Search or Wikipedia, ensuring the above scalability.

[0320] Therefore, the content storage unit according to one embodiment of the present invention 410 is linked to a web server to receive new content from the web server and update the content used to set questions.

[0321] 19 to 22 show a control unit 470 that searches for and collects new words and analyzes or classifies them.

[0322] Specifically, as shown in FIG. 19, the control unit 470 according to an embodiment of the present invention includes a word search and collection module that is linked with a server to update content used in question generation and searches for and collects new content from the server. 4701 A word analysis and classification module that analyzes the new content and classifies it into existing stages or categories. 4702 and

[0323] As shown in FIG. 19, content including at least one of text, words, and images can be searched or collected from a web server, which may include a database collected by a third party.

[0324] The searched or collected contents can be classified by level or item according to the classification method of the content storage unit 410 of the present invention and immediately stored in the content storage unit 410, or the analyzed or classified contents can be stored in a cloud server by level or item. The cognitive training DB can be stored in the cloud server to ensure scalability and ease of management of contents.

[0325] In addition, the word analysis and classification module according to an embodiment of the present invention 4702 If the content storage unit 410 has a higher concept word or a lower concept word related to the searched content, the word search and collection module stores the higher concept word or the lower concept word as a lower level of the higher concept word or a higher level of the lower concept word, and if the content storage unit 410 has no higher concept word or lower concept word related to the searched content, the word search and collection module can search for and collect the higher concept word or lower concept word related to the searched content.

[0326] It should be noted that the word analysis and classification module according to an embodiment of the present invention 4702 uses artificial intelligence to analyze or classify content, where the content may include at least one of words, sentences, and images.

[0327] Specifically, as shown in FIG. 21, the content storage unit 410 stores “things” as the first level, “inanimate objects” as the second level, “means of transportation” as the third level, and “automobiles” as the fourth level, and can classify concepts from higher to lower levels.

[0328] If word search and collection module4701 If searches for the word “car” from the web server as new content and cannot find it from the cloud server, it can be collected and stored in the cloud server or content store 410 .

[0329] At this time, as shown in FIG. 21(a), if a superordinate concept of the word "car" exists, but the superordinate concept does not exist in the content storage unit 410, the word search and collection module 4701 The word analysis and classification module searches for "transportation means," which is a superordinate concept of the word "car." 4702 can be classified as transportation means - automobiles and stored by stage.

[0330] Alternatively, as shown in FIG. 21(b), if there is a superordinate concept of the word "automobile" and this superordinate concept exists in content storage unit 410, "automobile" can be stored as a subordinate concept at the next level of the superordinate concept "means of transportation."

[0331] On the other hand, as shown in FIG. 21(c), when a sub-concept of the word “car” exists, which is a new content, the word search and collection module 4701 can search and collect words with subordinate concepts related to "automobile" and store them by classifying them into automobile-passenger car, bus, etc. Also, subordinate concepts of passenger car and bus can be searched and collected and stored in the next level after passenger car and bus. Words with subordinate concepts may overlap depending on the level, but even overlapping words with subordinate concepts have different words in the related superordinate level.

[0332] Also, as shown in FIG. 21(d), the contents can be stored in a total of five levels, namely, things-inanimate objects-transportation means-automobiles-passenger cars, and buses, by classifying them in the above-mentioned manner, and not only the words but also the levels of the words and related items can be stored in the content storage unit 410 or in a DB in the cloud server.

[0333] Furthermore, as shown in Fig. 21(e), images such as photographs, pictures, and figures related to the words can also be matched and stored, and stored in the content storage unit 410 or in a database on a cloud server. This can be used for problems such as finding words that match photographs.

[0334] In this case, when conducting cognitive training of "matching words to pictures" to stimulate the Wernicke's area in response to newly added words, or when conducting cognitive training of "matching object names" to stimulate the R-DLPSC, an image that matches the word is required.

[0335] Therefore, images can be classified using artificial intelligence, for example, images of trucks and cars can be searched and collected, and the truck images can be matched with the word "truck" stored in the fifth stage, and the "car" images can be matched with the word "car" stored in the fifth stage, and classified and stored. The artificial intelligence can be trained using a convolution neural network (CNN) or the like.

[0336] In another embodiment, the words collected through the search using the artificial intelligence may be classified and stored.

[0337] Therefore, as shown in FIG. 22, the word search and collection module 4701 searches for the word "car" as new content from the web server (S1401), and if the word is a new word not present in the content storage unit 410 ("No" in S1402), the word "car" can be collected (S1403). If the word is present in the content storage unit 410 ("Yes" in S1402), new content can be searched for again (S1401).

[0338] and a word analysis and classification module. 4702The word "automobile" is analyzed to determine whether there is a word that is a superordinate concept of the word (S1404), and whether there is a word that is a subordinate concept of the word (S1408).

[0339] Specifically, if a word with a higher concept than the word "automobile" exists (S1404: "Yes"), it is determined whether the higher concept word, for example, the word "transportation" exists in the DB or content storage unit 410 of the cloud server (S1405), and if the higher concept word exists (S1405: "Yes"), the DB or content storage unit 410 can add the lower concept word ("automobile") to a lower stage of the stage containing the higher concept word ("transportation").

[0340] On the other hand, if the word of the higher concept does not exist in the DB or the content storage unit 410 ("No" in 1405), the word search and collection module 4701 The system searches for words that are higher in concept than the current word "automobile" (S1407), collects these words, and stores them in stages by associating higher-concept words with lower-concept words.

[0341] If there is a word that is a subordinate concept of the word "car" ("Yes" in S1408), the word search and collection module 4701 However, additional searches are also performed for words that are subordinate concepts of the new word ("automobile") ("bus stop", "passenger car") (S1409), and the new word ("automobile") and its subordinate concepts ("bus stop", "passenger car") can be stored in stages in the DB or content storage unit 410.

[0342] That is, it is determined whether a superordinate word of the above word exists (S1404), and whether a subordinate word exists (S1408). After going through the above-mentioned classification and analysis, new content can be classified and transmitted to be stored in the cloud server's DB or content storage unit 410 (S1410).

[0343] Therefore, a personalized cognitive training method according to one embodiment of the present invention includes, in a personalized cognitive training device that performs multiple cognitive training exercises, the steps of inputting user data into the device and presenting predetermined types of questions depending on the brain area to be trained, determining a cognitive training result score based on feedback provided by the user for the presented questions, and determining questions for a next round based on the cognitive training result score of the current round, wherein the step of determining questions for the next round may change the question type for the next round based on the cognitive training result score.

[0344] In addition, the step of determining questions for the next round may change or maintain at least one of the difficulty and type of questions based on the cognitive training result score, and the change in the type of questions may be made when the change in the difficulty of the questions causes the cognitive training result score to fluctuate within a certain range. Specifically, the question pool may be changed to one including a question type related to the user data, or to one including a question type unrelated to the user data, so that the cognitive training result score for the next round is within a preset optimal score range.

[0345] Alternatively, the stage or item of the content storage unit may be changed so that the question pool is changed, and the stage or item may be changed by adjusting the priority for question presentation of items related to the user data using the user data inputted to the device and the cognitive training result score of the current round. Based on the inputted data, items that are related and items that are not related may be classified, and the question pool may be adjusted.

[0346] The magnetic stimulation method or the personalized cognitive training method according to the embodiment of the present invention may be produced as a program to be executed by a computer and stored in a computer-readable recording medium. Examples of the computer-readable recording medium include ROM, RAM, CD-ROM, magnetic tape, floppy disk, optical data storage device, etc. Also, the computer-readable recording medium may be distributed in a computer system connected by a network, and the computer-readable code may be stored and executed in a distributed manner. And, functional programs, codes, and code segments for implementing the above method may be easily construed by a programmer in the technical field to which the present invention belongs.

[0347] Furthermore, in describing the present invention, a "module" may be realized in a variety of ways, such as a processor, program instructions executed by a processor, a software module, microcode, a computer program product, a logic circuit, an application specific integrated circuit, firmware, etc.

[0348] In addition, for purposes of describing the present invention, "memory" may include either an external or internal storage device such as a USB, and a cloud server may be utilized as memory.

[0349] The present invention is not limited by the above-described embodiments and the accompanying drawings. The scope of the claims is limited by the appended claims, and it is obvious to those skilled in the art that various substitutions, modifications, and changes can be made within the scope of the technical idea of ​​the present invention described in the claims. [Explanation of symbols]

[0350] 100 Magnetic Field Generator 110 Control section 1101 Magnetic Field Conversion Module 1102 Motor Threshold Measurement Module 120, 120a, 120b Power Module 121 Power Conversion Module 130 Communication Module 140 Cooling Module 141 Cooling section 142 Temperature monitoring section 150 User Interface 151 Input Module 152 Output Module 160, 160a, 160b coils 200 Brain Navigation Device 210 MRI Data Memory 220 Mapping Module 221 Camera Club 222 IR LED section 230 Laser Scanner 240 Laser Pointer 250 Communication Module 260 Control Unit 270 Power Supply Module 300 Integrated Operator 301 User Interface 302 Second Memory 400 Personalized Cognitive Training Device 401 User Interface 402 First Memory 410 Content Storage Unit 4101 Vocabulary Module 4102 Sentence Structure Module 4103 User Data Module 420 Question section 430 Score Judgment Department 440 Problem Change Department 450 Input section 460 Output section 470 Control Unit 4401 Level Adjustment Module 4402 Pool Conversion Module 4701 Word Search and Collection Module 4702 Word Analysis and Classification Module

Claims

1. The magnetic field generator is A control unit that determines a corresponding magnetic field output taking into account user data including motor threshold and the brain region to be stimulated. a power module coupled to the coil generating the magnetic field and configured to supply power to the coil so that the coil generates the determined magnetic field; The control unit includes a motor threshold measurement module that measures the motor threshold of the user using a magnetic field adjustment module, and a magnetic field adjustment module that uses an MRI image of the user to adjust a magnetic field-related parameter to control a magnetic field output determined based on the treatment position information of the MRI image, a distance to a brain region to be stimulated, and a state of the user's brain including at least one of the morphology, size, and shape of the user's brain, and the measured motor threshold; The relevant parameters of the magnetic field include magnetic field strength and magnetic field frequency; The motor threshold measurement module, when the motor threshold is not measured even when the magnetic field strength reaches a maximum output, increases the magnetic field frequency by a preset ratio, adjusts the magnetic field strength, and measures the user's motor threshold.

2. the power module is coupled to each of the multiple coils configured to simultaneously stimulate multiple brain regions, and supplies power to each of the multiple coils; 10. The magnetic stimulation system of claim 1, wherein the magnetic field adjustment module determines a magnetic field output of each of the multiple coils and adjusts associated parameters of the magnetic fields of each of the multiple coils to respectively control the magnetic field output.

3. The motor threshold measurement module includes: The magnetic stimulation system of claim 1 or 2, wherein the magnetic field adjustment module adjusts the magnetic field strength stepwise to measure the motor threshold of the user.

4. a brain navigation device that analyzes an MRI image of a user to detect a position of a brain region to be stimulated and guides the position of the magnetic field generating device; The brain navigation device comprises: an MRI data memory for receiving and storing an MRI image of the user and location data of the brain region to be stimulated; a mapping module for capturing an actual head image of the user in real time using a camera, and mapping the actual head image captured in real time with the user's brain MRI image, which is displayed with the position data of the brain region to be stimulated and is stored in the MRI data memory; 3. The magnetic stimulation system of claim 1 , further comprising: a robotic arm that receives position coordinates of a brain region to be stimulated in the actual head acquired by the mapping module, and moves the coil to a position corresponding to the position coordinates.

5. The multi-coil simultaneously or at a time interval stimulates at least one brain region located on the right side of the user and at least one brain region located on the left side of the user at a position corresponding to the brain region located on the right side of the user and the brain region located on the left side of the user, or Stimulating at least two or more brain regions located on the right side of the user simultaneously or at intervals in a magnetic field at a position corresponding to the brain region located on the right side of the user; or Stimulating at least two or more brain regions located on the left side of the user simultaneously or at intervals at a position corresponding to the brain region located on the left side of the user; 3. The magnetic stimulation system of claim 2, wherein when the multiple coils perform magnetic field stimulation simultaneously or at time intervals, the magnetic field frequencies, cycles, time, and strengths of the magnetic fields of the multiple coils are controlled to be the same or different.

6. A magnetic field generating device comprising: a control unit that determines a corresponding magnetic field output in consideration of user data including a motor threshold (MT) and a brain region to be stimulated; and a power module that is coupled to a coil that generates a magnetic field and supplies power to the coil to generate the determined magnetic field output, adjusting the magnetic field strength or frequency of the coil to measure the motor threshold of the user; positioning said coil in a position on the head corresponding to the location of the brain region to be stimulated; and driving the coil with magnetic field information determined by using an MRI image of the user, taking into consideration the distance to the brain region to be stimulated, the state of the user's brain including at least one of the shape, size, and head shape of the user's brain, and the measured motor threshold of the user, thereby performing brain stimulation; The step of measuring the user's motor threshold includes, if the user's motor threshold is not measured even when the magnetic field strength reaches a maximum output, increasing the frequency by a preset ratio to adjust the magnetic field strength and measure the user's motor threshold. The magnetic stimulation system includes: a processor configured to execute each step of a magnetic stimulation method; and a memory that drives the coil with the user's motor threshold or the determined magnetic field information and stores data on brain stimulation.

7. Measuring the motor threshold of the user includes: A first step of magnetically stimulating the motor cortex of the user using the coil and checking whether there is finger movement or checking for motor changes using a motor threshold measurement sensor; a second step of increasing the magnetic field strength at a preset ratio when there is no movement or change in the motility of the finger until there is movement or a change in the motility of the finger, and decreasing the magnetic field strength to a critical value at which the finger does not respond or returns to a previous motility state when there is movement or a change in the motility of the finger, and determining the critical value as the motility threshold; 7. The magnetic stimulation system of claim 6, comprising:

8. The magnetic stimulation method comprises: The method further includes a step of performing cognitive training using a cognitive training device simultaneously or alternately with the step of performing the brain stimulation, 7. The magnetic stimulation system of claim 6, wherein at least one of the frequency, period, and time of the magnetic field generated by the magnetic field generating device and the period and time for solving the cognitive training problem performed by the cognitive training device are controlled in consideration of at least one of the brain area to be stimulated, user data, and the type of cognitive training problem performed by the cognitive training device.

9. In the step of driving the coil to stimulate the brain, when a multi-coil is driven to stimulate multiple brain regions simultaneously or at time intervals, The magnetic stimulation system of claim 6 , further comprising controlling, by a magnetic field adjustment module, at least one of a frequency, a period, a time, and an intensity of the magnetic fields of the multi-coils to be the same or different.

10. 10. The magnetic stimulation system of claim 6, further comprising a transceiver for remotely communicating with the processor to execute the magnetic stimulation system. A magnetic stimulation system in which the memory stores data on the user's motor threshold or the determined magnetic field information used to drive a coil to perform brain stimulation in a cloud server, enabling remote medical treatment.

11. A magnetic field generating device comprising: a control unit that determines a corresponding magnetic field output taking into account user data including motor threshold (MT) and a brain region to be stimulated; and a power module coupled to a coil generating the magnetic field and providing power to the coil to generate the determined magnetic field output, adjusting the magnetic field strength or frequency of the coil to measure the motor threshold of the user; positioning said coil in a position on the head corresponding to the location of the brain region to be stimulated; and driving the coil with magnetic field information determined by using an MRI image of the user, taking into consideration the distance to the brain region to be stimulated, the state of the user's brain including at least one of the shape, size, and head shape of the user's brain, and the measured motor threshold of the user, to perform brain stimulation; A computer-readable recording medium having a program recorded thereon for executing a magnetic stimulation method on a computer, the magnetic stimulation method including, when the user's motor threshold is not measured even when the magnetic field strength reaches a maximum output, a step of increasing the frequency by a preset ratio, adjusting the magnetic field strength, and measuring the user's motor threshold.

Images