TYK2 INHIBITORS AND USES THEREOF

Abstract

Described herein are compounds useful for treating TYK2-mediated disorders. In some embodiments, the TYK2-mediated disorder is an autoimmune disorder, an inflammatory disorder, a proliferative disorder, an endocrine disorder, a neurological disorder, or a transplant-related disorder.

Description

[Technical Field]

[0001] cross reference This patent application claims the benefit of U.S. Provisional Patent Application No. 62 / 749,003, filed October 22, 2018, U.S. Provisional Patent Application No. 62 / 756,942, filed November 7, 2018, U.S. Provisional Patent Application No. 62 / 839,459, filed April 26, 2019, U.S. Provisional Patent Application No. 62 / 875,449, filed July 17, 2019, U.S. Provisional Patent Application No. 62 / 893,721, filed August 29, 2019, and U.S. Provisional Patent Application No. 62 / 907,354, filed September 27, 2019, each of which is incorporated herein by reference in its entirety.

[0002] Described herein are compounds that inhibit nonreceptor-protein kinase 2 (TYK2), also known as tyrosine kinase 2, methods for making the compounds, pharmaceutical compositions and medicaments containing the compounds, and methods for using the compounds. [Background technology]

[0003] TYK2 is a non-receptor tyrosine kinase member of the Janus kinase (JAK) family of protein kinases. The mammalian JAK family consists of four members: TYK2, JAK1, JAK2, and JAK3. JAK proteins, including TYK2, are essential for cytokine signaling. TYK2 associates with the cytoplasmic domains of type I and type II cytokine receptors and type I and type III interferon receptors and is activated by these receptors upon cytokine binding. Cytokines involved in TYK2 activation include interferons (e.g., IFN-α, IFN-β, IFN-κ, IFN-δ, IFN-ε, IFN-τ, IFN-ω, and IFN-ζ (also known as limitin)) and interleukins (e.g., IL-4, IL-6, IL-10, IL-11, IL-12, IL-13, IL-22, IL-23, IL-27, IL-31, oncostatin M, ciliary neurotrophic factor, cardiotrophin 1, cardiotrophin-like cytokine, and LIF). Activated TYK2 then phosphorylates additional signaling proteins, such as members of the STAT family, including STAT1, STAT2, STAT4, and STAT6.

[0004] Activation of TYK2 by IL-23 is associated with inflammatory bowel disease (IBD), Crohn's disease, and ulcerative colitis. A genome-wide association study of 2,622 psoriasis patients identified an association between disease susceptibility and TYK2. TYK2 knockout or tyrphostin inhibition significantly reduced both IL-23- and IL-22-induced dermatitis.

[0005] TYK2 also plays a role in respiratory diseases such as asthma, chronic obstructive pulmonary disease (COPD), lung cancer, and cystic fibrosis. Goblet cell hyperplasia (GCH) and mucus hypersecretion are mediated by IL-13-induced TYK2 activation, which in turn activates STAT6.

[0006] Decreased TYK2 activity protects joints from collagen antibody-induced arthritis, a model of human rheumatoid arthritis. Mechanistically, reduced Tyk2 activity reduces Th1 / Th17-associated cytokine production and decreases the production of matrix metalloproteinases and other key markers of inflammation.

[0007] TYK2 knockout mice were completely resistant to experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis (MS), and showed reduced CD4 T cell infiltration in the spinal cord compared with controls, suggesting that TYK2 is essential for the development of pathogenic CD4-mediated disease in MS. This finding reinforces previous studies linking increased TYK2 expression to MS susceptibility. Loss-of-function mutations in TYK2 result in reduced demyelination and increased remyelination of neurons. This further suggests a role for TYK2 inhibitors in the treatment of MS and other demyelinating disorders of the CNS.

[0008] TYK2 is the only signaling messenger common to both IL-12 and IL-23. TYK2 knockout reduced footpad thickness induced by methylated BSA injection, imiquimod-induced psoriasis-like dermatitis, and dextran sulfate sodium- or 2,4,6-trinitrobenzenesulfonic acid-induced colitis in mice.

[0009] Linkage and association studies of systemic lupus erythematosus (SLE, an autoimmune disorder) with various type I IFN signaling genes have shown a strong and significant correlation between loss of function mutations in TYK2 and a reduced prevalence of SLE in families with affected members. Genome-wide association studies of individuals from SLE and unaffected cohorts have shown a highly significant correlation between the TYK2 locus and SLE.

[0010] TYK2 has been shown to play a critical role in sustaining tumor surveillance, and TYK2 knockout mice have been shown to exhibit impaired cytotoxic T cell responses and accelerated tumor progression. However, these effects correlate with efficient suppression of natural killer (NK) and cytotoxic T lymphocytes, suggesting that TYK2 inhibitors may be well suited for the treatment of autoimmune disorders or transplant rejection. While other JAK family members, such as JAK3, have similar roles in the immune system, TYK2 has been proposed as a superior target because it participates in fewer and more closely related signaling pathways, potentially reducing off-target effects.

[0011] Studies of T-cell acute lymphoblastic leukemia (T-ALL) have shown that T-ALL is highly dependent on IL-10 via TYK2 through STAT1-mediated signaling, sustaining cancer cell survival through upregulation of the anti-apoptotic protein BCL2. Knocking down TYK2, but not other JAK family members, reduced cell proliferation. Specific TYK2 activating mutations that promote cancer cell survival include mutations in the FERM domain (G36D, S47N, and R425H), JH2 domain (V731I), and kinase domain (E957D and R1027H). However, TYK2 enzymes characterized by loss-of-kinase mutations (M978Y or M978F) in addition to the activating mutation (E957D) failed to transform, demonstrating that the kinase function of TYK2 is required for enhanced cancer cell survival.

[0012] Therefore, selective inhibition of TYK2 has been proposed as a suitable target for patients with IL-10- and / or BCL2-dependent tumors, which account for 70% of cases of adult T-cell leukemia, for example. TYK2-mediated STAT3 signaling has also been shown to mediate neuronal cell death induced by amyloid-β (Aβ) peptides. Reduced TYK2 phosphorylation of STAT3 after Aβ administration reduces neuronal cell death. Increased STAT3 phosphorylation has been observed in postmortem brains of Alzheimer's patients.

[0013] Inhibition of the JAK-STAT signaling pathway has also been implicated in hair growth and reversal of hair loss associated with alopecia areata.

[0014] Therefore, compounds that inhibit the activity of TYK2, particularly those with selectivity over JAK2, would be beneficial and should produce pharmacological responses that successfully treat one or more of the conditions described herein without the side effects associated with inhibition of JAK2.

[0015] Thus, there is a need to provide novel inhibitors that have more potent or advantageous pharmaceutically relevant properties, such as selectivity over other JAK kinases (particularly JAK2). Summary of the Invention

[0016] Disclosed herein is a compound of formula (XII) below, or a pharmaceutically acceptable salt, solvate, or stereoisomer thereof: [ka] During the ceremony: Ring B is cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; R 16 is -C(=O)NR 1 R 2 , -C(=N-CN)NR 1 R2 , -P(=O)R 1 R 2 , or -C(=O)R 11 and; R 1 and R 2 are independently hydrogen, C 1- C6 alkyl, C 1- C6 haloalkyl, C 1- C6 deuterated alkyl, C 1- C6 hydroxyalkyl, C 1- C6 amino alkyl, C 2- C6 alkenyl, or C 2- C6 alkynyl; R 3 is hydrogen, C 1- C6 alkyl, C 1- C6 haloalkyl, or C 1- C6 deuterated alkyl; R 4 is hydrogen, deuterium, halogen, -CN, -OR b , -SR b , -S(=O)R a , -S(=O)2R a , -NO2, -NR c R d , -NHS(=O)2R a , -S(=O)2NR c R d , -C(=O)R a , -OC(=O)R a , -C(=O)OR b , -OC(=O)OR b , -C(=O)NR c R d , -OC(=O)NR c R d , -NR b C(=O)NR c R d , -NR b C(=O)R a , -NR b C(=O)OR b , -P(=O)R b R b , C 1- C6 alkyl, C 1-C6 haloalkyl, C 1- C6 deuterated alkyl, C 1- C6 hydroxyalkyl, C 1- C6 amino alkyl, C 2- C6 alkenyl, or C 2- C6 alkynyl; or R 3 and R 4 together form an optionally substituted ring; L is a bond or -C(=O)-; Ring A is a cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; each of which is selected from the group consisting of one or more R A optionally replaced by; Each R A are independently deuterium, halogen, -CN, -OR b , -SR b , -S(=O)R a , -S(=O)2R a , -NO2, -NR c R d , -NHS(=O)2R a , -S(=O)2NR c R d , -C(=O)R a , -OC(=O)R a , -C(=O)OR b , -OC(=O)OR b , -C(=O)NR c R d , -OC(=O)NR c R d , -NR b C(=O)NR c R d , -NR b C(=O)R a , -NR b C(=O)OR b , C 1- C6 alkyl, C 1- C6 haloalkyl, C 1- C6 deuterated alkyl, C 1- C6 hydroxyalkyl, C 1- C6 amino alkyl, C 2- C6 alkenyl, C 2-C6 alkynyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; wherein each of the alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl independently represents one or more of oxo, deuterium, halogen, -CN, -OR b , -NR c R d , -C(=O)R a , -C(=O)OR b , -C(=O)NR c R d , C 1- C6 alkyl, or C 1- optionally substituted with C6 haloalkyl; or two R on the same carbon A together form oxo; or -L-ring A is absent; Each X is independently -CR x -or-N-; Each R X are independently hydrogen, deuterium, halogen, -CN, -OR b , -SR b , -S(=O)R a , -S(=O)2R a , -NO2, -NR c R d , -NHS(=O)2R a , -S(=O)2NR c R d , -C(=O)R a , -OC(=O)R a , -C(=O)OR b , -OC(=O)OR b , -C(=O)NR c R d , -OC(=O)NR c R d , -NR b C(=O)NR c R d , -NR b C(=O)R a , -NR b C(=O)OR b , C 1- C6 alkyl, C1- C6 haloalkyl, C 1- C6 deuterated alkyl, C 1- C6 hydroxyalkyl, C 1- C6 amino alkyl, C 2- C6 alkenyl, or C 2- C6 alkynyl; R 5 is halogen, -CN, -OR 8 , -SR 8 , -S(=O)R 7 , -S(=O)2R 7 , -NO2, -NR 9 R 10 , -NR 8 S(=O)R 7 , -NR 8 S(=O)2R 7 , -S(=O)2NR 9 R 10 , -C(=N-CN)R 7 ,-C(=O)R 7 , -OC(=N-CN)R 7 , -OC(=O)R 7 , -C(=N-CN)OR 8 , -C(=O)OR 8 , -OC(=N-CN)OR 8 , -OC(=O)OR 8 , -C(=N-CN)NR 9 R 10 , -C(=O)NR 9 R 10 , -OC(=N-CN)NR 9 R 10 , -OC(=O)NR 9 R 10 , -NR 8 C(=N-CN)NR 9 R 10 , -NR 8 C(=O)NR 9 R 10 , -NR 8 C(=N-CN)R 7 , -NR 8 C(=N-OH)R 7 , -NR 8 C(=N-CN)OR 8 , -NR8 C(=O)OR 8 , -NR 8 S(=O)(=NR 8 )R 7 , C 1- C6 alkyl, C 1- C6 haloalkyl, C 1- C6 deuterated alkyl, C 1- C6 hydroxyalkyl, C 1- C6 amino alkyl, C 2- C6 alkenyl, C 2- C alkynyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; wherein each of the alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl independently represents one or more of oxo, deuterium, halogen, -CN, -OR b , -NR c R d , -C(=O)R a , -C(=O)OR b , -C(=O)NR c R d , C 1- C6 alkyl, C 1- C6 haloalkyl, C 1- C6 deuterated alkyl, C 1- C6 hydroxyalkyl, C 1- C6 amino alkyl, C 1- C6 heteroalkyl, C 2- C6 alkenyl, C 2- C6 alkynyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, C 1- C6 alkyl (cycloalkyl), C 1- C6 alkyl (heterocycloalkyl), C 1- C6 alkyl (aryl), or C 1- and optionally substituted with C alkyl (heteroaryl); in which case each of alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl independently may be one or more of oxo, deuterium, halogen, -CN, -OR b , -NR c R d, -C(=O)R a , -C(=O)OR b , -C(=O)NR c R d , C 1- C6 alkyl, or C 1- optionally substituted with C6 haloalkyl; R 7 is C 1- C6 alkyl, C 1- C6 haloalkyl, C 1- C6 deuterated alkyl, C 1- C6 hydroxyalkyl, C 1- C6 amino alkyl, C 2- C6 alkenyl, C 2- C alkynyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; wherein each of the alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl independently represents one or more of oxo, deuterium, halogen, —CN, —OH, —OMe, —NH, —C(═O)Me, —C(═O)OH, —C(═O)OMe, C 1- C6 alkyl, or C 1- optionally substituted with C6 haloalkyl; Each R 8 are independently hydrogen, CN, C 1- C6 alkyl, C 1- C6 haloalkyl, C 1- C6 deuterated alkyl, C 1- C6 hydroxyalkyl, C 1- C6 amino alkyl, C 2- C6 alkenyl, C 2- C alkynyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; wherein each of the alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl independently represents one or more of oxo, deuterium, halogen, —CN, —OH, —OMe, —NH, —C(═O)Me, —C(═O)OH, —C(═O)OMe, C 1- C6 alkyl, or C 1- optionally substituted with C6 haloalkyl; R 9 and R 10 are independently hydrogen, C1-C6 alkyl, C1-C6 haloalkyl, C1-C6 deuterated alkyl, C1-C6 hydroxyalkyl, C1-C6 aminoalkyl, C2-C6 alkenyl, C2-C6 alkynyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; wherein each of alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl independently represents one or more of oxo, deuterium, halogen, —CN, —OH, —OMe, —NH2, —C(═O)Me, —C(═O)OH, —C(═O)OMe, C 1- C6 alkyl, C1-C6 deuterated alkyl, C1-C6 haloalkyl, C1-C6 hydroxyalkyl, C 1- optionally substituted with C6 hydroxydeuterated alkyl, cycloalkyl, or heterocycloalkyl; or R 9 and R 10 together with the nitrogen atom to which they are attached, one or more of oxo, deuterium, halogen, -CN, -OH, -OMe, -NH2, -C(=O)Me, -C(=O)OH, -C(=O)OMe, C 1- C6 alkyl, or C 1- forming a heterocycloalkyl optionally substituted with C6 haloalkyl; or R 8 and R 9 together with the atoms to which they are attached, one or more of oxo, deuterium, halogen, -CN, -OH, -OMe, -NH2, -C(=O)Me, -C(=O)OH, -C(=O)OMe,C 1- C6 alkyl, or C 1- forming a heterocycloalkyl optionally substituted with C6 haloalkyl; R 11is C1-C6 alkyl, C1-C6 haloalkyl, C1-C6 deuterated alkyl, C1-C6 hydroxyalkyl, C1-C6 aminoalkyl, C2-C6 alkenyl, C2-C6 alkynyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; wherein each of alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl is independently selected from one or more R 11a optionally replaced by; Each R 11a are independently deuterium, halogen, -CN, -OR b , -SR b , -S(=O)R a , -S(=O)2R a , -NO2, -NR c R d , -NHS(=O)2R a , -S(=O)2NR c R d , -C(=O)R a , -OC(=O)R a , -C(=O)OR b , -OC(=O)OR b , -C(=O)NR c R d , -OC(=O)NR c R d , -NR b C(=O)NR c R d , -NR b C(=O)R a , -NR b C(=O)OR b , C 1- C6 alkyl, C 1- C6 haloalkyl, C 1- C6 deuterated alkyl, C 1- C6 hydroxyalkyl, C 1- C6 amino alkyl, C 2- C6 alkenyl, or C 2- C6 alkynyl; Each R a independently, C 1- C6 alkyl, C 1- C6 haloalkyl, C1- C6 deuterated alkyl, C 1- C6 hydroxyalkyl, C 1- C6 amino alkyl, C 2- C6 alkenyl, C 2- C alkynyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; wherein each of alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl independently represents one or more of oxo, deuterium, halogen, —CN, —OH, —OMe, —NH, —C(═O)Me, —C(═O)OH, —C(═O)OMe, C 1- C6 alkyl, or C 1- optionally substituted with C6 haloalkyl; Each R b are independently hydrogen, C 1- C6 alkyl, C 1- C6 haloalkyl, C 1- C6 deuterated alkyl, C 1- C6 hydroxyalkyl, C 1- C6 amino alkyl, C 2- C6 alkenyl, C 2- C alkynyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; wherein each of the alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl independently represents one or more of oxo, deuterium, halogen, —CN, —OH, —OMe, —NH, —C(═O)Me, —C(═O)OH, —C(═O)OMe, C 1- C6 alkyl, or C 1- optionally substituted with C6 haloalkyl; Each R c and R d are independently hydrogen, C 1- C6 alkyl, C 1- C6 haloalkyl, C 1- C6 deuterated alkyl, C 1- C6 hydroxyalkyl, C 1- C6 amino alkyl, C 2- C6 alkenyl, C 2-C alkynyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; wherein each of the alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl independently represents one or more of oxo, deuterium, halogen, —CN, —OH, —OMe, —NH, —C(═O)Me, —C(═O)OH, —C(═O)OMe, C 1- C6 alkyl, or C 1- optionally substituted with C6 haloalkyl; or R c and R d together with the nitrogen atom to which they are attached, one or more of oxo, deuterium, halogen, -CN, -OH, -OMe, -NH2, -C(=O)Me, -C(=O)OH, -C(=O)OMe, C 1- C6 alkyl, or C 1- Forms a heterocycloalkyl optionally substituted with C6 haloalkyl.

[0017] Disclosed herein is a compound of formula (XIII) below, or a pharmaceutically acceptable salt, stereoisomer, or solvate thereof: [ka] During the ceremony: Ring B is cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; R 3 is hydrogen, C 1- C6 alkyl, C 1- C6 haloalkyl, or C 1- C6 deuterated alkyl; R 4 is hydrogen, deuterium, halogen, -CN, -OR b , -SR b , -S(=O)R a , -S(=O)2R a , -NO2, -NR c R d , -NHS(=O)2R a , -S(=O)2NR c Rd , -C(=O)R a , -OC(=O)R a , -C(=O)OR b , -OC(=O)OR b , -C(=O)NR c R d , -OC(=O)NR c R d , -NR b C(=O)NR c R d , -NR b C(=O)R a , -NR b C(=O)OR b , -P(=O)R b R b , C 1- C6 alkyl, C 1- C6 haloalkyl, C 1- C6 deuterated alkyl, C 1- C6 hydroxyalkyl, C 1- C6 amino alkyl, C 2- C6 alkenyl, or C 2- C6 alkynyl; or R 3 and R 4 together form an optionally substituted ring; L is a bond or -C(=O)-; Ring A is a cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; each of which is selected from the group consisting of one or more R A optionally replaced by; Each R A are independently deuterium, halogen, -CN, -OR b , -SR b , -S(=O)R a , -S(=O)2R a , -NO2, -NR c R d , -NHS(=O)2R a , -S(=O)2NR c R d , -C(=O)R a , -OC(=O)R a , -C(=O)OR b, -OC(=O)OR b , -C(=O)NR c R d , -OC(=O)NR c R d , -NR b C(=O)NR c R d , -NR b C(=O)R a , -NR b C(=O)OR b , C 1- C6 alkyl, C 1- C6 haloalkyl, C 1- C6 deuterated alkyl, C 1- C6 hydroxyalkyl, C 1- C6 amino alkyl, C 2- C6 alkenyl, C 2- C alkynyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; wherein each of the alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl independently represents one or more of oxo, deuterium, halogen, -CN, -OR b , -NR c R d , -C(=O)R a , -C(=O)OR b , -C(=O)NR c R d , C 1- C6 alkyl, or C 1- optionally substituted with C6 haloalkyl; or two R on the same carbon A together form oxo; or -L-ring A is absent; Each X is independently -CR x -or-N-; Each R X are independently hydrogen, deuterium, halogen, -CN, -OR b , -SR b , -S(=O)R a , -S(=O)2R a , -NO2, -NR c R d, -NHS(=O)2R a , -S(=O)2NR c R d , -C(=O)R a , -OC(=O)R a , -C(=O)OR b , -OC(=O)OR b , -C(=O)NR c R d , -OC(=O)NR c R d , -NR b C(=O)NR c R d , -NR b C(=O)R a , -NR b C(=O)OR b , , C1-C6 alkyl, C1-C6 haloalkyl, C1-C6 deuterated alkyl, C1-C6 hydroxyalkyl, C1-C6 aminoalkyl, C2-C6 alkenyl, or C2-C6 alkynyl; R 5 is halogen, -CN, -OR 8 , -SR 8 , -S(=O)R 7 , -S(=O)2R 7 , -NO2, -NR 9 R 10 , -NR 8 S(=O)R 7 , -NR 8 S(=O)2R 7 , -S(=O)2NR 9 R 10 , -C(=N-CN)R 7 ,-C(=O)R 7 , -OC(=N-CN)R 7 , -OC(=O)R 7 , -C(=N-CN)OR 8 , -C(=O)OR 8 , -OC(=N-CN)OR 8 , -OC(=O)OR 8 , -C(=N-CN)NR 9 R 10 , -C(=O)NR 9 R 10, -OC(=N-CN)NR 9 R 10 , -OC(=O)NR 9 R 10 , -NR 8 C(=N-CN)NR 9 R 10 , -NR 8 C(=O)NR 9 R 10 , -NR 8 C(=N-CN)R 7 , -NR 8 C(=N-OH)R 7 , -NR 8 C(=O)R 7 , -NR 8 C(=N-CN)OR 8 , -NR 8 C(=O)OR 8 , -NR 8 S(=O)(=NR 8 )R 7 , C 1- C6 alkyl, C 1- C6 haloalkyl, C 1- C6 deuterated alkyl, C 1- C6 hydroxyalkyl, C 1- C6 amino alkyl, C 2- C6 alkenyl, C 2- C alkynyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; wherein each of the alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl independently represents one or more of oxo, deuterium, halogen, -CN, -OR b , -NR c R d , -C(=O)R a , -C(=O)OR b , -C(=O)NR c R d ,C 1- C6 alkyl, or C 1- C6 haloalkyl, C 1- C6 deuterated alkyl, C 1- C6 hydroxyalkyl, C 1- C6 aminoalkyl, C1-C6 heteroalkyl, C2- C6 alkenyl, C 2- optionally substituted with C6 alkynyl, cycloalkyl, heterocycloalkyl, aryl or heteroaryl, C1-C6 alkyl(cycloalkyl), C1-C6 alkyl(heterocycloalkyl), C1-C6 alkyl(aryl), or C1-C6 alkyl(heteroaryl); wherein each of alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl independently may be one or more of oxo, deuterium, halogen, -CN, -OR b , -NR c R d , -C(=O)R a , -C(=O)OR b , -C(=O)NR c R d ,,C 1- C6 alkyl, or C 1- optionally substituted with C6 haloalkyl; R 7 is C 1- C6 alkyl, C 1- C6 haloalkyl, C 1- C6 deuterated alkyl, C 1- C6 hydroxyalkyl, C 1- C6 amino alkyl, C 2- C6 alkenyl, C 2- C alkynyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; wherein each of alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl independently represents one or more of oxo, deuterium, halogen, —CN, —OH, —OMe, —NH, —C(═O)Me, —C(═O)OH, —C(═O)OMe,C 1- C6 alkyl, or C 1- optionally substituted with C6 haloalkyl; Each R 8 are independently hydrogen, CN, C 1- C6 alkyl, C 1- C6 haloalkyl, C 1- C6 deuterated alkyl, C 1- C6 hydroxyalkyl, C1- C6 amino alkyl, C 2- C6 alkenyl, C 2- C alkynyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; in this case, each of the alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl independently represents one or more of oxo, deuterium, halogen, —CN, —OH, —OMe, —NH2, —C(═O)Me, —C(═O)OH, —C(═O)OMe, C 1- C6 alkyl, or C 1- optionally substituted with C6 haloalkyl; R 9 and R 10 are independently hydrogen, C1-C6 alkyl, C1-C6 haloalkyl, C1-C6 deuterated alkyl, C1-C6 hydroxyalkyl, C1-C6 aminoalkyl, C2-C6 alkenyl, C2-C6 alkynyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; wherein each of alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl independently represents one or more of oxo, deuterium, halogen, —CN, —OH, —OMe, —NH2, —C(═O)Me, —C(═O)OH, —C(═O)OMe, C 1- C6 alkyl, C1-C6 deuterated alkyl, C1-C6 haloalkyl, C1-C6 hydroxyalkyl, C 1- optionally substituted with C6 hydroxydeuterated alkyl, cycloalkyl, or heterocycloalkyl; or R 9 and R 10 together with the nitrogen atom to which they are attached, one or more of oxo, deuterium, halogen, -CN, -OH, -OMe, -NH2, -C(=O)Me, -C(=O)OH, -C(=O)OMe, C 1- C6 alkyl, or C 1- forming a heterocycloalkyl optionally substituted with C6 haloalkyl; or R 8 and R 9together with the atoms to which they are attached, one or more of oxo, deuterium, halogen, -CN, -OH, -OMe, -NH2, -C(=O)Me, -C(=O)OH, -C(=O)OMe, C 1- C6 alkyl, or C 1- forming a heterocycloalkyl optionally substituted with C6 haloalkyl; R 11 is C1-C6 alkyl, C1-C6 haloalkyl, C1-C6 deuterated alkyl, C1-C6 hydroxyalkyl, C1-C6 aminoalkyl, C2-C6 alkenyl, C2-C6 alkynyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; wherein each of alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl is independently selected from one or more R 11a optionally replaced by; Each R 11a are independently deuterium, halogen, -CN, -OR b , -SR b , -S(=O)R a , -S(=O)2R a , -NO2, -NR c R d , -NHS(=O)2R a , -S(=O)2NR c R d , -C(=O)R a , -OC(=O)R a , -C(=O)OR b , -OC(=O)OR b , -C(=O)NR c R d , -OC(=O)NR c R d , -NR b C(=O)NR c R d , -NR b C(=O)R a , -NR b C(=O)OR b ,C 1- C6 alkyl, C 1- C6 haloalkyl, C 1- C6 deuterated alkyl, C1- C6 hydroxyalkyl, C 1- C6 amino alkyl, C 2- C6 alkenyl, or C 2- C6 alkynyl; Each R a independently, C 1- C6 alkyl, C 1- C6 haloalkyl, C 1- C6 deuterated alkyl, C 1- C6 hydroxyalkyl, C 1- C6 amino alkyl, C 2- C6 alkenyl, C 2- C alkynyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; wherein each of the alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl independently represents one or more of oxo, deuterium, halogen, —CN, —OH, —OMe, —NH, —C(═O)Me, —C(═O)OH, —C(═O)OMe, C 1- C6 alkyl, or C 1- optionally substituted with C6 haloalkyl; Each R b are independently hydrogen, C 1- C6 alkyl, C 1- C6 haloalkyl, C 1- C6 deuterated alkyl, C 1- C6 hydroxyalkyl, C 1- C6 amino alkyl, C 2- C6 alkenyl, C 2- C alkynyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; wherein each of alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl independently represents one or more of oxo, deuterium, halogen, —CN, —OH, —OMe, —NH, —C(═O)Me, —C(═O)OH, —C(═O)OMe, C 1- C6 alkyl, or C 1- optionally substituted with C6 haloalkyl; Each R c and R dare independently hydrogen, C 1- C6 alkyl, C 1- C6 haloalkyl, C 1- C6 deuterated alkyl, C 1- C6 hydroxyalkyl, C 1- C6 amino alkyl, C 2- C6 alkenyl, C 2- C alkynyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; wherein each of the alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl independently represents one or more of oxo, deuterium, halogen, —CN, —OH, —OMe, —NH, —C(═O)Me, —C(═O)OH, —C(═O)OMe, C 1- C6 alkyl, or C 1- optionally substituted with C6 haloalkyl; or R c and R d together with the nitrogen atom to which they are attached, one or more of oxo, deuterium, halogen, -CN, -OH, -OMe, -NH2, -C(=O)Me, -C(=O)OH, -C(=O)OMe, C 1- C6 alkyl, or C 1- Forms a heterocycloalkyl optionally substituted with C6 haloalkyl.

[0018] Also disclosed herein are pharmaceutical compositions comprising a therapeutically effective amount of a compound disclosed herein, or a pharmaceutically acceptable salt, stereoisomer, or solvate thereof, and a pharmaceutically acceptable excipient.

[0019] Also disclosed herein is a method of inhibiting the TYK2 enzyme in a patient or biological sample, the method comprising contacting the patient or biological sample with a compound disclosed herein or a pharmaceutically acceptable salt, stereoisomer, or solvate thereof.

[0020] Also disclosed herein are methods of treating a TYK2-mediated disorder, the methods comprising administering to a patient in need thereof a compound disclosed herein, or a pharmaceutically acceptable salt, stereoisomer, or solvate thereof. In some embodiments, the TYK2-mediated disorder is an autoimmune disorder, an inflammatory disorder, a proliferative disorder, an endocrine disorder, a neurological disorder, or a transplant-related disorder. In some embodiments, the disorder is associated with type I interferon, IL-10, IL-12, or IL-23 signaling. Incorporation by Reference

[0021] All publications, patents, and patent applications mentioned herein are hereby incorporated by reference for the specific purposes identified herein. DETAILED DESCRIPTION OF THE INVENTION

[0022] definition As used in this specification and the appended claims, the singular forms (a, an, and the) include plural referents unless the context clearly dictates otherwise. Thus, for example, a reference to "an agent" includes a plurality of such agents, and a reference to "the cell" includes a reference to one or more cells (or cells) and equivalents thereof known to those of skill in the art. When ranges are used herein with respect to physical properties, such as molecular weight, or chemical properties, such as chemical formula, all combinations and subcombinations of ranges and specific embodiments therein are intended to be included. The term "about," when referring to a numerical value or numerical range, indicates that the referenced number or numerical range is approximate within experimental variation (or statistical experimental error); therefore, in some instances, the number or numerical range will vary between 1% and 15% of the stated number or numerical range. The term "comprising" (and related terms, e.g., "comprising," or "having," or "containing") is not intended to exclude that in other particular embodiments, the embodiment, e.g., any composition of matter, composition of matter, method, or process described herein, "consists of" or "consists essentially of" the described characteristics.

[0023] As used in this specification and the appended claims, unless specified to the contrary, the following terms have the meanings indicated below.

[0024] "Aliphatic chain" refers to a linear chemical moiety consisting only of carbon and hydrogen. In some embodiments, an aliphatic chain is saturated. In some embodiments, an aliphatic chain is unsaturated. In some embodiments, an unsaturated aliphatic chain contains one unsaturation. In some embodiments, an unsaturated aliphatic chain contains two or more unsaturations. In some embodiments, an unsaturated aliphatic chain contains two unsaturations. In some embodiments, an unsaturated aliphatic chain contains one double bond. In some embodiments, an unsaturated aliphatic chain contains two double bonds.

[0025] "Alkyl" refers to an optionally substituted straight-chain or optionally substituted branched-chain saturated hydrocarbon monoradical having 1 to about 10 carbon atoms, or 1 to 6 carbon atoms. Examples include, but are not limited to, methyl, ethyl, n-propyl, isopropyl, 2-methyl-1-propyl, 2-methyl-2-propyl, 2-methyl-1-butyl, 3-methyl-1-butyl, 2-methyl-3-butyl, 2,2-dimethyl-1-propyl, 2-methyl-1-pentyl, 3-methyl-1-pentyl, 4-methyl-1-pentyl, 2-methyl-2-pentyl, 3-methyl-2-pentyl, 4-methyl-2-pentyl, 2,2-dimethyl-1-butyl, 3,3-dimethyl-1-butyl, 2-ethyl-1-butyl, n-butyl, isobutyl, sec-butyl, t-butyl, n-pentyl, isopentyl, neopentyl, tert-amyl, and hexyl, as well as longer chain alkyl groups such as heptyl, butyl, etc. As used herein, the term "C" refers to, for example, "C" or "C" groups. 1- Numerical ranges such as "C alkyl" mean that the alkyl group in question consists of 1 carbon atom, 2 carbon atoms, 3 carbon atoms, 4 carbon atoms, 5 carbon atoms, or 6 carbon atoms; this definition also applies when the term "alkyl" appears without a numerical range being specified. In some embodiments, alkyl is a C 1- C 10 Alkyl, C 1- C9 alkyl, C 1- C8 alkyl, C 1- C7 alkyl, C 1- C6 alkyl, C 1- C5 alkyl, C 1- C4 alkyl, C 1- C3 alkyl, C 1-C2 alkyl or C1 alkyl. Unless otherwise specifically stated herein, alkyl groups are optionally substituted with, for example, oxo, halogen, amino, nitrile, nitro, hydroxyl, haloalkyl, alkoxy, aryl, cycloalkyl, heterocycloalkyl, heteroaryl, etc. In some embodiments, alkyl is optionally substituted with oxo, halogen, -CN, -CF3, OH, -OMe, NH2, or -NO2. In some embodiments, alkyl is optionally substituted with oxo, halogen, -CN, -CF3, -OH, or -OMe. In some embodiments, alkyl is optionally substituted with halogen.

[0026] "Alkenyl" refers to an optionally substituted straight-chain or optionally substituted branched-chain hydrocarbon monoradical having one or more carbon-carbon double bonds or having from 2 to about 10 carbon atoms, preferably from 2 to about 6 carbon atoms. The radical may be in either the cis or trans conformation about the double bond, and it is understood that both isomers are included. Examples include, but are not limited to, ethenyl (-CH=CH), 1-propenyl (-CHCH=CH), isopropenyl [-C(CH)=CH], butenyl, 1,3-butadienyl, and the like. As used herein, for example, "C 2- Numerical ranges such as "C6 alkenyl" mean that the alkenyl group can consist of 2 carbon atoms, 3 carbon atoms, 4 carbon atoms, 5 carbon atoms, or 6 carbon atoms; this definition also applies when the term "alkenyl" appears without a numerical range. In some embodiments, alkenyl is a C 2- C 10 Alkenyl, C 2- C9 alkenyl, C 2- C8 alkenyl, C 2- C7 alkenyl, C 2- C6 alkenyl, C 2- C5 alkenyl, C 2- C4 alkenyl, C 2-C alkenyl or C alkenyl. Unless otherwise specifically stated herein, alkenyl groups are optionally substituted with, for example, oxo, halogen, amino, nitrile, nitro, hydroxyl, haloalkyl, alkoxy, aryl, cycloalkyl, heterocycloalkyl, heteroaryl, etc. In some embodiments, alkenyl is optionally substituted with oxo, halogen, -CN, -CF, OH, -OMe, NH, or -NO. In some embodiments, alkenyl is optionally substituted with oxo, halogen, -CN, -CF, OH, or -OMe. In some embodiments, alkenyl is optionally substituted with halogen.

[0027] "Alkynyl" refers to an optionally substituted straight-chain or optionally substituted branched-chain hydrocarbon monoradical having one or more carbon-carbon triple bonds or having from 2 to about 10 carbon atoms, more preferably from 2 to about 6 carbon atoms. Examples include, but are not limited to, ethynyl, 2-propynyl, 2-butynyl, 1,3-butadiynyl, and the like. As used herein, for example, "C 2- Numerical ranges such as "C6 alkynyl" mean that the alkynyl group in question can consist of 2 carbon atoms, 3 carbon atoms, 4 carbon atoms, 5 carbon atoms, or 6 carbon atoms; this definition also applies when the term "alkynyl" appears without a numerical range being specified. In some embodiments, alkynyl is a C 2- C 10 Alkynyl, C 2- C9 alkynyl, C 2- C8 alkynyl, C 2- C7 alkynyl, C 2- C6 alkynyl, C 2- C5 alkynyl, C 2- C4 alkynyl, C 2-C alkynyl or C alkynyl. Unless otherwise specifically stated herein, alkynyl groups are optionally substituted with, for example, oxo, halogen, amino, nitrile, nitro, hydroxyl, haloalkyl, alkoxy, aryl, cycloalkyl, heterocycloalkyl, heteroaryl, etc. In some embodiments, alkynyl is optionally substituted with oxo, halogen, -CN, -CF, OH, -OMe, NH, or -NO. In some embodiments, alkynyl is optionally substituted with oxo, halogen, -CN, -CF, OH, or -OMe. In some embodiments, alkynyl is optionally substituted with halogen.

[0028] "Alkylene" refers to a straight or branched divalent hydrocarbon chain. Unless otherwise specifically stated herein, an alkylene group can be optionally substituted with, for example, oxo, halogen, amino, nitrile, nitro, hydroxyl, haloalkyl, alkoxy, aryl, cycloalkyl, heterocycloalkyl, heteroaryl, etc. In some embodiments, an alkylene is optionally substituted with oxo, halogen, -CN, -CF, OH, -OMe, NH, or -NO. In some embodiments, an alkylene is optionally substituted with oxo, halogen, -CN, -CF, OH, or -OMe. In some embodiments, an alkylene is optionally substituted with halogen.

[0029] "Alkoxy" means a group of the formula -OR a where R ais an alkyl radical as defined. Unless otherwise specifically stated herein, an alkoxy group can be optionally substituted with, for example, oxo, halogen, amino, nitrile, nitro, hydroxyl, haloalkyl, alkoxy, aryl, cycloalkyl, heterocycloalkyl, heteroaryl, etc. In some embodiments, an alkoxy is optionally substituted with oxo, halogen, -CN, -CF, OH, -OMe, NH, or -NO. In some embodiments, an alkoxy is optionally substituted with oxo, halogen, CN, -CF, OH, or -OMe. In some embodiments, an alkoxy is optionally substituted with halogen.

[0030] "Aminoalkyl" refers to an alkyl radical, as defined above, substituted with one or more amines. In some embodiments, the alkyl is substituted with one amine. In some embodiments, the alkyl is substituted with one, two, or three amines. Examples of hydroxyalkyl include aminomethyl, aminoethyl, aminopropyl, aminobutyl, or aminopentyl. In some embodiments, the hydroxyalkyl is aminomethyl.

[0031] "Aryl" refers to a radical derived from a hydrocarbon ring system containing hydrogen, 6 to 30 carbon atoms, and at least one aromatic ring. The aryl radical may be a monocyclic, bicyclic, tricyclic, or tetracyclic ring system and may include fused (when fused to a cycloalkyl or heterocycloalkyl ring, the aryl is attached through an aromatic ring atom) or bridged ring systems. In some embodiments, an aryl is a 6- to 10-membered aryl. In some embodiments, an aryl is a 6-membered aryl. Aryl radicals include, but are not limited to, aryl radicals derived from anthrylene, naphthylene, phenanthrylene, anthracene, azulene, benzene, chrysene, fluoranthene, fluorene, as-indacene, s-indacene, indane, indene, naphthalene, phenalene, phenanthrene, pleiadene, pyrene, and triphenylene hydrocarbon ring systems. In some embodiments, an aryl is phenyl. Unless otherwise specifically stated herein, aryl can be optionally substituted with, for example, halogen, amino, nitrile, nitro, hydroxyl, alkyl, alkenyl, alkynyl, haloalkyl, alkoxy, aryl, cycloalkyl, heterocycloalkyl, heteroaryl, etc. In some embodiments, aryl is optionally substituted with halogen, methyl, ethyl, -CN, -CF, OH, -OMe, NH, or -NO. In some embodiments, aryl is optionally substituted with halogen, methyl, ethyl, -CN, -CF, OH, or -OMe. In some embodiments, aryl is optionally substituted with halogen.

[0032] "Cycloalkyl" refers to a stable, partially or fully saturated, monocyclic or polycyclic carbocyclic ring, which may include fused (when fused to an aryl or heteroaryl ring, the cycloalkyl is attached through a non-aromatic ring atom) or bridged ring systems. Representative cycloalkyls include, but are not limited to, cycloalkyls containing 3 to 15 carbon atoms (C 3- C 15 cycloalkyl), 3 to 10 carbon atoms (C 3- C10 cycloalkyl), 3 to 8 carbon atoms (C 3- C8 cycloalkyl), 3 to 6 carbon atoms (C 3- C6 cycloalkyl), 3 to 5 carbon atoms (C 3- C5 cycloalkyl), or 3-4 carbon atoms (C 3- C4 cycloalkyl). In some embodiments, the cycloalkyl is a 3- to 6-membered cycloalkyl. In some embodiments, the cycloalkyl is a 5- to 6-membered cycloalkyl. Examples of monocyclic cycloalkyls include cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cycloheptyl, and cyclooctyl. Examples of polycyclic cycloalkyls or carbocycles include adamantyl, norbornyl, decalinyl, bicyclo[3.3.0]octane, bicyclo[4.3.0]nonane, cis-decalin, trans-decalin, bicyclo[2.1.1]hexane, bicyclo[2.2.1]heptane, bicyclo[2.2.2]octane, bicyclo[3.2.2]nonane, and bicyclo[3.3.2]decane, and 7,7-dimethyl-bicyclo[2.2.1]heptanyl. Examples of partially saturated cycloalkyl include cyclopentenyl, cyclohexenyl, cycloheptenyl, and cyclooctenyl. Unless otherwise specifically stated herein, cycloalkyl is optionally substituted with, for example, oxo, halogen, amino, nitrile, nitro, hydroxyl, alkyl, alkenyl, alkynyl, haloalkyl, alkoxy, aryl, cycloalkyl, heterocycloalkyl, heteroaryl, etc. In some embodiments, cycloalkyl is optionally substituted with oxo, halogen, methyl, ethyl, -CN, -CF, OH, -OMe, NH, or -NO. In some embodiments, cycloalkyl is optionally substituted with oxo, halogen, methyl, ethyl, -CN, -CF, OH, or -OMe. In some embodiments, cycloalkyl is optionally substituted with halogen.

[0033] "Deuteroalkyl" refers to an alkyl radical, as defined above, that is substituted with one or more deuterium atoms. In some embodiments, the alkyl is substituted with one deuterium atom. In some embodiments, the alkyl is substituted with one, two, or three deuterium atoms. In some embodiments, the alkyl is substituted with one, two, three, four, five, or six deuterium atoms. Examples of deuterated alkyls include CD3, CH2D, CHD2, CH2CD3, CD2CD3, CHDCD3, CH2CH2D, or CH2CHD2. In some embodiments, the deuterated alkyl is CD3.

[0034] "Haloalkyl" refers to an alkyl radical, as defined above, substituted with one or more halogen atoms. In some embodiments, the alkyl is substituted with 1, 2, or 3 halogen atoms. In some embodiments, the alkyl is substituted with 1, 2, 3, 4, 5, or 6 halogen atoms. Examples of haloalkyl include trifluoromethyl, difluoromethyl, fluoromethyl, trichloromethyl, 2,2,2-trifluoroethyl, 1,2-difluoroethyl, 3-bromo-2-fluoropropyl, 1,2-dibromoethyl, and the like. In some embodiments, the haloalkyl is trifluoromethyl.

[0035] "Halo" or "halogen" refers to bromo, chloro, fluoro, or iodo. In some embodiments, the halogen is fluoro or chloro. In some embodiments, the halogen is fluoro.

[0036] "Heteroalkyl" refers to an alkyl group in which one or more skeletal atoms of the alkyl are selected from atoms other than carbon, such as oxygen, nitrogen (e.g., -NH-, -N(alkyl)-), sulfur, or combinations thereof. A heteroalkyl is attached to the remainder of the molecule at a carbon atom of the heteroalkyl. In one embodiment, a heteroalkyl is a C1-C6 heteroalkyl, where the heteroalkyl consists of 1 to 6 carbon atoms and one or more non-carbon atoms, such as oxygen, nitrogen (e.g., -NH-, -N(alkyl)-), sulfur, or combinations thereof, where the heteroalkyl is attached to the remainder of the molecule at a carbon atom of the heteroalkyl. Examples of such heteroalkyls are, for example, -CHOCH3, -CHCHOCH3, -CHCHOCH2CH2OCH3, or -CH(CH3)OCH3. Unless otherwise specifically stated herein, heteroalkyl is optionally substituted with, for example, oxo, halogen, amino, nitrile, nitro, hydroxyl, alkyl, alkenyl, alkynyl, haloalkyl, alkoxy, aryl, cycloalkyl, heterocycloalkyl, heteroaryl, etc. In some embodiments, heteroalkyl is optionally substituted with oxo, halogen, methyl, ethyl, -CN, -CF, OH, -OMe, NH, or -NO. In some embodiments, heteroalkyl is optionally substituted with oxo, halogen, methyl, ethyl, -CN, -CF, OH, or -OMe. In some embodiments, heteroalkyl is optionally substituted with halogen.

[0037] "Hydroxyalkyl" refers to an alkyl radical, as defined above, substituted with one or more hydroxyls. In some embodiments, the alkyl is substituted with one hydroxyl. In some embodiments, the alkyl is substituted with one, two, or three hydroxyls. Examples of hydroxyalkyl include hydroxymethyl, hydroxyethyl, hydroxypropyl, hydroxybutyl, or hydroxypentyl. In some embodiments, the hydroxyalkyl is hydroxymethyl.

[0038] "Heterocycloalkyl" refers to a stable 3- to 24-membered, partially saturated or fully saturated ring radical containing 2 to 23 carbon atoms and 1 to 8 heteroatoms selected from the group consisting of nitrogen, oxygen, phosphorus, and sulfur. In some embodiments, heterocycloalkyls contain 1 or 2 heteroatoms selected from nitrogen and oxygen. Unless specifically stated otherwise in the specification, heterocycloalkyl radicals can be monocyclic, bicyclic, tricyclic, or tetracyclic ring systems, which can include fused (when fused to an aryl or heteroaryl ring, the heterocycloalkyl is attached through a non-aromatic ring atom) or bridged ring systems. The nitrogen, carbon, or sulfur atoms in the heterocycloalkyl radical can be optionally oxidized, and the nitrogen atom can be optionally quaternized. Representative heterocycloalkyls include, but are not limited to, heterocycloalkyls containing 2 to 15 carbon atoms (C 2- C 15 heterocycloalkyl), 2 to 10 carbon atoms (C 2- C 10 heterocycloalkyl), 2 to 8 carbon atoms (C 2-Heterocycloalkyls include heterocycloalkyls having 2 to 6 carbon atoms (C-C heterocycloalkyl), 2 to 5 carbon atoms (C-C heterocycloalkyl), or 2 to 4 carbon atoms (C-C heterocycloalkyl). In some embodiments, a heterocycloalkyl is a 3- to 6-membered heterocycloalkyl. In some embodiments, a cycloalkyl is a 5- to 6-membered heterocycloalkyl. Examples of such heterocycloalkyl radicals include, but are not limited to, aziridinyl, azetidinyl, dioxolanyl, thienyl [1, 3] Dithianyl, decahydroisoquinolyl, imidazolinyl, imidazolidinyl, isothiazolidinyl, isoxazolidinyl, morpholinyl, octahydroindolyl, octahydroisoindolyl, 2-oxopiperazinyl, 2-oxopiperidinyl, 2-oxopyrrolidinyl, oxazolidinyl, piperidinyl, piperazinyl, 4-piperidonyl, pyrrolidinyl, pyrazolidinyl, quinuclidinyl, thiazolidinyl Examples of heterocycloalkyl include tetrahydrofuryl, trithianyl, tetrahydropyranyl, thiomorpholinyl, thiamorpholinyl, 1-oxo-thiomorpholinyl, 1,1-dioxo-thiomorpholinyl, 1,3-dihydroisobenzofuran-1-yl, 3-oxo-1,3-dihydroisobenzofuran-1-yl, methyl-2-oxo-1,3-dioxol-4-yl, and 2-oxo-1,3-dioxol-4-yl. The term heterocycloalkyl also includes, but is not limited to, carbohydrates of all ring types, including monosaccharides, disaccharides, and oligosaccharides. When referring to the number of carbon atoms in a heterocycloalkyl, it is understood that the number of carbon atoms in the heterocycloalkyl is not the same as the total number of atoms (including heteroatoms) comprising the heterocycloalkyl (i.e., the skeletal atoms of the heterocycloalkyl ring). Unless stated otherwise specifically in the specification, heterocycloalkyls are optionally substituted with, for example, oxo, halogen, amino, nitrile, nitro, hydroxyl, alkyl, alkenyl, alkynyl, haloalkyl, alkoxy, aryl, cycloalkyl, heterocycloalkyl, heteroaryl, etc.In some embodiments, heterocycloalkyl is optionally substituted with oxo, halogen, methyl, ethyl, -CN, -CF3, OH, -OMe, NH2, or -NO2. In some embodiments, heterocycloalkyl is optionally substituted with oxo, halogen, methyl, ethyl, -CN, -CF3, OH, or -OMe. In some embodiments, heterocycloalkyl is optionally substituted with halogen.

[0039] "Heteroalkyl" refers to an alkyl group in which one or more skeletal atoms of the alkyl are selected from atoms other than carbon, such as oxygen, nitrogen (e.g., -NH-, -N(alkyl)-), sulfur, or combinations thereof. A heteroalkyl is attached to the remainder of the molecule at a carbon atom of the heteroalkyl. In one embodiment, a heteroalkyl is a C 1- C heteroalkyl. Unless otherwise specifically stated herein, heteroalkyl is optionally substituted with, for example, oxo, halogen, amino, nitrile, nitro, hydroxyl, alkyl, alkenyl, alkynyl, haloalkyl, alkoxy, aryl, cycloalkyl, heterocycloalkyl, heteroaryl, etc. In some embodiments, heteroalkyl is optionally substituted with oxo, halogen, methyl, ethyl, -CN, -CF, OH, -OMe, NH, or -NO. In some embodiments, heteroalkyl is optionally substituted with oxo, halogen, methyl, ethyl, -CN, -CF, OH, or -OMe. In some embodiments, heteroalkyl is optionally substituted with halogen.

[0040] "Heteroaryl" refers to a 5- to 14-membered ring system radical containing a hydrogen atom, 1 to 13 carbon atoms, 1 to 6 heteroatoms selected from the group consisting of nitrogen, oxygen, phosphorus, and sulfur, and at least one aromatic ring. The heteroaryl radical can be a monocyclic, bicyclic, tricyclic, or tetracyclic ring system, and the ring system can include fused (when fused to a cycloalkyl or heterocycloalkyl ring, the heteroaryl is bonded through an aromatic ring atom) or bridged ring systems. The nitrogen, carbon, or sulfur atoms in the heteroaryl radical can be optionally oxidized, and the nitrogen atom can be optionally quaternized. In some embodiments, the heteroaryl is a 5- to 10-membered heteroaryl. In some embodiments, the heteroaryl is a 5- to 6-membered heteroaryl.Examples include, but are not limited to, azepinyl, acridinyl, benzimidazolyl, benzothiazolyl, benzindolyl, benzodioxolyl, benzofuranyl, benzoxazolyl, benzothiazolyl, benzothiadiazolyl, benzo[b][1,4]dioxepinyl, 1,4-benzodioxanyl, benzonaphthofuranyl, benzoxazolyl, benzodioxolyl, benzodioxinyl, benzopyranyl, benzopyranonyl, benzofuranyl, benzofuranonyl, benzothienyl (benzothiophenyl), benzotriazolyl, benzo[4,6]imidazo[1,2-a]pyridinyl, carbazolyl, cinnolinyl, dibenzofuranyl, dibenzothiophenyl, furanyl, furanonyl, isothiazolyl, imidazolyl, indazolyl, indolyl, indophenyl, and benzotriazolyl. Examples include dazolyl, isoindolyl, indolinyl, isoindonyi, isoquinolyl, indolizinyl, isoxazolyl, naphthyridinyl, oxadiazolyl, 2-oxoazepinyl, oxazolyl, oxiranyl, 1-oxidopyridinyl, 1-oxidopyrimidinyl, 1-oxidopyrazinyl, 1-oxidopyridazinyl, 1-phenyl-1H-pyrrolyl, phenazinyl, phenothiazinyl, phenoxazinyl, phthalazinyl, pteridinyl, purinyl, pyrrolyl, pyrazolyl, pyridinyl, pyrazinyl, pyrimidinyl, pyridazinyl, quinazolinyl, quinoxalinyl, quinolinyl, quinuclidinyl, isoquinolinyl, tetrahydroquinolinyl, thiazolyl, thiadiazolyl, triazolyl, tetrazolyl, triazinyl, and thiophenyl (i.e., thienyl). Unless otherwise specifically stated herein, heteroaryl is optionally substituted with, for example, halogen, amino, nitrile, nitro, hydroxyl, alkyl, alkenyl, alkynyl, haloalkyl, alkoxy, aryl, cycloalkyl, heterocycloalkyl, heteroaryl, etc. In some embodiments, heteroaryl is optionally substituted with halogen, methyl, ethyl, -CN, -CF, OH, -OMe, NH, or -NO. In some embodiments, heteroaryl is optionally substituted with halogen, methyl, ethyl, -CN, -CF, OH, or -OMe.In some embodiments, the heteroaryl is optionally substituted with halogen.

[0041] As used herein, the terms "treat," "prevent," "ameliorate," and "inhibit," and phrases derived therefrom, do not necessarily imply 100% or complete treatment, prevention, amelioration, or inhibition. Rather, there are various degrees of such treatment, prevention, amelioration, and inhibition, which one of skill in the art would recognize as having potential benefit or therapeutic effect. In this regard, the disclosed methods can provide any amount of any level of treatment, prevention, amelioration, or inhibition in a mammal. For example, a disorder, including its symptoms or conditions, may be reduced by about 100%, about 90%, about 80%, about 70%, about 60%, about 50%, about 40%, about 30%, about 20%, or about 10%. Furthermore, the treatment, prevention, amelioration, or inhibition provided by the methods disclosed herein can include treatment, prevention, amelioration, or inhibition of one or more conditions or symptoms of a disorder, such as cancer or an inflammatory disease. For purposes of this specification, "treatment," "prevention," "amelioration," or "inhibition" also encompasses delaying the onset of a disorder or the development of its symptoms or conditions.

[0042] As used herein, the term "effective amount" or "therapeutically effective amount" refers to a sufficient quantity of a compound disclosed herein being administered to relieve to some extent one or more of the symptoms or conditions of the disease being treated, such as, for example, cancer or an inflammatory disease. In some embodiments, the result is a reduction and / or alleviation of the signs, symptoms, or causes of the disease, or any other desired alteration of a biological system. For example, an "effective amount" for therapeutic use is the quantity of a composition comprising a compound disclosed herein that is required to produce a clinically meaningful reduction in disease symptoms. In some embodiments, an appropriate "effective" amount in any individual case is determined using techniques such as, for example, a dose escalation study.

[0043] As used herein, the term "TYK2-mediated" disorder, disease, and / or condition means any disease or other deleterious condition in which TYK2 or a variant thereof is known to play a role. Accordingly, another embodiment relates to treating or lessening the severity of one or more diseases in which TYK2 or a variant thereof is known to play a role. Such TYK2-mediated disorders include, but are not limited to, autoimmune disorders, inflammatory disorders, proliferative disorders, endocrine disorders, neurological disorders, and transplant-related disorders. compound

[0044] Described herein are compounds useful for treating TYK2-mediated disorders. In some embodiments, the TYK2-mediated disorder is an autoimmune disorder, an inflammatory disorder, a proliferative disorder, an endocrine disorder, a neurological disorder, or a transplant-related disorder.

[0045] Disclosed herein are compounds of formula (I) below, or a pharmaceutically acceptable salt, solvate, or stereoisomer thereof: [ka] During the ceremony: Z is a bond, -CR Z 2- , or -(CR Z 2)2- and; Each R Z are independently hydrogen, deuterium, halogen, -CN, -OR b , -NR c R d , C 1- C6 alkyl, C 1- C6 haloalkyl, or C 1- C6 deuterated alkyl; R 1 and R 2 are independently hydrogen, C 1- C6 alkyl, C 1- C6 haloalkyl, C 1- C6 deuterated alkyl, C 1- C6 hydroxyalkyl, C 1-C6 amino alkyl, C 2- C6 alkenyl, or C 2- C6 alkynyl; R 3 is hydrogen, C 1- C6 alkyl, C 1- C6 haloalkyl, or C 1- C6 deuterated alkyl; R 4 is hydrogen, deuterium, halogen, -CN, -OR b , -SR b , -S(=O)R a , -S(=O)2R a , -NO2, -NR c R d , -NHS(=O)2R a , -S(=O)2NR c R d , -C(=O)R a , -OC(=O)R a , -C(=O)OR b , -OC(=O)OR b , -C(=O)NR c R d , -OC(=O)NR c R d , -NR b C(=O)NR c R d , -NR b C(=O)R a , -NR b C(=O)OR b , C 1- C6 alkyl, C 1- C6 haloalkyl, C 1- C6 deuterated alkyl, C 1- C6 hydroxyalkyl, C 1- C6 amino alkyl, C 2- C6 alkenyl, or C 2- C6 alkynyl; or R 3 and R 4 together form an optionally substituted ring; L is a bond or -C(=O)-; Ring A is a cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; each of which is selected from the group consisting of one or more R A optionally replaced by; Each R A are independently deuterium, halogen, -CN, -OR b , -SR b , -S(=O)R a , -S(=O)2R a , -NO2, -NR c R d , -NHS(=O)2R a , -S(=O)2NR c R d , -C(=O)R a , -OC(=O)R a , -C(=O)OR b , -OC(=O)OR b , -C(=O)NR c R d , -OC(=O)NR c R d , -NR b C(=O)NR c R d , -NR b C(=O)R a , -NR b C(=O)OR b , C1-C6 alkyl, C1-C6 haloalkyl, C1-C6 deuterated alkyl, C1-C6 hydroxyalkyl, C1-C6 aminoalkyl, C2-C6 alkenyl, C2-C6 alkynyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; wherein each of alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl independently represents one or more of oxo, deuterium, halogen, -CN, -OR b , -NR c R d , -C(=O)R a , -C(=O)OR b , -C(=O)NR c R d , optionally substituted with C1-C6 alkyl, or C1-C6 haloalkyl; or two R on the same carbon A together form oxo; R 5 is halogen, -CN, -OR 8 , -SR 8 , -S(=O)R 7 , -S(=O)2R 7 , -NO2, -NR 9 R 10 , -NHS(=O)2R 7 , -S(=O)2NR 9 R 10 , -C(=O)R 7 , -OC(=O)R 7 , -C(=O)OR 8 , -OC(=O)OR 8 , -C(=O)NR 9 R 10 , -OC(=O)NR 9 R 10 , -NR 8 C(=O)NR 9 R 10 , -NR 8 C(=O)R 7 , -NR 8 C(=O)OR 8 , C 1- C6 alkyl, C 1- C6 haloalkyl, C 1- C6 deuterated alkyl, C 1- C6 hydroxyalkyl, C 1- C6 amino alkyl, C 2- C6 alkenyl, C 2- C6 alkynyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; wherein each of the alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl independently represents one or more of oxo, deuterium, halogen, -CN, -OR b , -NR c R d , -C(=O)R a , -C(=O)OR b , -C(=O)NR c R d , C 1- C6 alkyl, or C1- optionally substituted with C6 haloalkyl; R 7 is C 1- C6 alkyl, C 1- C6 haloalkyl, C 1- C6 deuterated alkyl, C 1- C6 hydroxyalkyl, C 1- C6 amino alkyl, C 2- C6 alkenyl, C 2- C alkynyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; wherein each of the alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl independently represents one or more of oxo, deuterium, halogen, —CN, —OH, —OMe, —NH, —C(═O)Me, —C(═O)OH, —C(═O)OMe, C 1- C6 alkyl, or C 1- optionally substituted with C6 haloalkyl; Each R 8 are independently hydrogen, C 1- C6 alkyl, C 1- C6 haloalkyl, C 1- C6 deuterated alkyl, C 1- C6 hydroxyalkyl, C 1- C6 amino alkyl, C 2- C6 alkenyl, C 2- C alkynyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; wherein each of the alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl independently represents one or more of oxo, deuterium, halogen, —CN, —OH, —OMe, —NH, —C(═O)Me, —C(═O)OH, —C(═O)OMe, —C 1- C6 alkyl, or C 1- optionally substituted with C6 haloalkyl; R 9 and R 10 are independently hydrogen, C 1- C6 alkyl, C 1- C6 haloalkyl, C 1-C6 deuterated alkyl, C 1- C6 hydroxyalkyl, C 1- C6 amino alkyl, C 2- C6 alkenyl, C 2- C alkynyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; wherein each of the alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl independently represents one or more of oxo, deuterium, halogen, —CN, —OH, —OMe, —NH, —C(═O)Me, —C(═O)OH, —C(═O)OMe, C 1- C6 alkyl, or C 1- optionally substituted with C6 haloalkyl; or R 9 and R 10 together with the nitrogen atom to which they are attached, one or more of oxo, deuterium, halogen, -CN, -OH, -OMe, -NH2, -C(=O)Me, -C(=O)OH, -C(=O)OMe,C 1- C6 alkyl, or C 1- forming a heterocycloalkyl optionally substituted with C6 haloalkyl; Each R a independently, C 1- C6 alkyl, C 1- C6 haloalkyl, C 1- C6 deuterated alkyl, C 1- C6 hydroxyalkyl, C 1- C6 amino alkyl, C 2- C6 alkenyl, C 2- C alkynyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; wherein each of the alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl independently represents one or more of oxo, deuterium, halogen, —CN, —OH, —OMe, —NH, —C(═O)Me, —C(═O)OH, —C(═O)OMe, C 1- C6 alkyl, or C 1- optionally substituted with C6 haloalkyl; Each R bare independently hydrogen, C 1- C6 alkyl, C 1- C6 haloalkyl, C 1- C6 deuterated alkyl, C 1- C6 hydroxyalkyl, C 1- C6 amino alkyl, C 2- C6 alkenyl, C 2- C alkynyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; wherein each of the alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl independently represents one or more of oxo, deuterium, halogen, —CN, —OH, —OMe, —NH, —C(═O)Me, —C(═O)OH, —C(═O)OMe, —C 1- C6 alkyl, or C 1- optionally substituted with C6 haloalkyl; Each R c and R d are independently hydrogen, C 1- C6 alkyl, C 1- C6 haloalkyl, C 1- C6 deuterated alkyl, C 1- C6 hydroxyalkyl, C 1- C6 amino alkyl, C 2- C6 alkenyl, C 2- C alkynyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; wherein each of alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl independently represents one or more of oxo, deuterium, halogen, —CN, —OH, —OMe, —NH, —C(═O)Me, —C(═O)OH, —C(═O)OMe, C 1- C6 alkyl, or C 1- optionally substituted with C6 haloalkyl; or R c and R d together with the nitrogen atom to which they are attached, one or more of oxo, deuterium, halogen, -CN, -OH, -OMe, -NH2, -C(=O)Me, -C(=O)OH, -C(=O)OMe, C1- C6 alkyl, or C 1- Forms a heterocycloalkyl optionally substituted with C6 haloalkyl.

[0046] In some embodiments of the compounds of Formula (I), L is a bond. In some embodiments of the compounds of Formula (I), L is -C(=O)-.

[0047] In some embodiments of compounds of Formula (I), ring A is heterocycloalkyl or heteroaryl; each of which contains one or more R A In some embodiments of compounds of Formula (I), ring A is a 5-membered heterocycloalkyl or a 5-membered heteroaryl; each optionally substituted with one or more R A In some embodiments of the compounds of Formula (I), ring A is optionally substituted with one or more R A is heteroaryl optionally substituted with

[0048] In some embodiments of the compounds of Formula (I), each R A are independently deuterium, halogen, -CN, -OR b , -NR c R d , -C(=O)R a , -C(=O)OR b , -C(=O)NR c R d , -OC(=O)NR c R d , C1-C6 alkyl, C1-C6 haloalkyl, or C1-C6 deuterated alkyl. In some embodiments of compounds of Formula (I), each R A is independently deuterium, halogen, C1-C6 alkyl, C1-C6 haloalkyl, or C1-C6 deuterated alkyl. In some embodiments of compounds of Formula (I), each R A is independently halogen or C1-C6 alkyl. In some embodiments of the compound of Formula (I), each R A are independently C1-C6 alkyl.

[0049] In some embodiments of the compounds of Formula (I), R4 is hydrogen, deuterium, halogen, -CN, -OR b , -NR c R d , -C(=O)R a , -C(=O)OR b , -C(=O)NR c R d , -OC(=O)NR c R d , C 1- C6 alkyl, C 1- C6 haloalkyl, or C 1- In some embodiments of the compounds of formula (I), R 4 is hydrogen or -OR b In some embodiments of the compounds of Formula (I), R 4 -OR b In some embodiments of the compounds of Formula (I), R 4 is hydrogen.

[0050] In some embodiments of the compound of Formula (I), the compound is a compound of Formula (Ia): [ka]

[0051] In some embodiments of the compound of Formula (I), the compound is a compound of Formula (Ib): [ka]

[0052] In some embodiments of compounds of Formula (I), (Ia) or (Ib), R 3 is hydrogen or C1-C6 alkyl. In some embodiments of compounds of Formula (I), (Ia) or (Ib), R 3 is hydrogen.

[0053] In some embodiments of the compound of Formula (I), (Ia) or (Ib), Z is a bond or -CH2-. In some embodiments of the compound of Formula (I), (Ia) or (Ib), Z is -CH2-. In some embodiments of the compound of Formula (I), (Ia) or (Ib), Z is a bond.

[0054] In some embodiments of compounds of Formula (I), (Ia) or (Ib), R 1 and R 2 is independently hydrogen, C-C alkyl, C-C haloalkyl, or C-C deuterated alkyl. In some embodiments of compounds of Formula (I), (Ia), or (Ib), R 1 and R 2 is independently hydrogen, or C1-C6 deuterated alkyl. In some embodiments of compounds of Formula (I), (Ia) or (Ib), R 1 is hydrogen. In some embodiments of compounds of Formula (I), (Ia) or (Ib), R 2 is C1-C6 alkyl, or C1-C6 deuterated alkyl. In some embodiments of compounds of Formula (I), (Ia) or (Ib), R 2 is a C1-C6 deuterated alkyl.

[0055] In some embodiments of compounds of Formula (I), (Ia) or (Ib), R 5 is halogen, -CN, -OR 8 , -NR 9 R 10 , -C(=O)R 7 , -C(=O)OR 8 , -C(=O)NR 9 R 10 , -NR 8 C(=O)NR 9 R 10 , -NR 8 C(=O)R 7 , -NR 8 C(=O)OR 8 , C 1- C6 alkyl, C 1- C6 haloalkyl, C 1- C6 deuterated alkyl, C2- C6 alkenyl, C 2- C alkynyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; wherein each of the alkyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl independently represents one or more of oxo, deuterium, halogen, -CN, -OR b , -NR c R d , -C(=O)R a , -C(=O)OR b , -C(=O)NR c R d , C 1- C6 alkyl, or C 1- Optionally substituted with C6 haloalkyl.

[0056] In some embodiments of compounds of Formula (I), (Ia) or (Ib), R 5 -OR 8 , -NR 9 R 10 , -C(=O)R 7 , -C(=O)OR 8 , -C(=O)NR 9 R 10 , -NR 8 C(=O)NR 9 R 10 , -NR 8 C(=O)R 7 , -NR 8 C(=O)OR 8 , cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; wherein each of the cycloalkyl, heterocycloalkyl, aryl, and heteroaryl independently represents one or more of oxo, deuterium, halogen, —CN, —OR b , -NR c R d , -C(=O)R a , -C(=O)OR b , -C(=O)NR c R d , C 1- C6 alkyl, or C 1- Optionally substituted with C6 haloalkyl.

[0057] In some embodiments of compounds of Formula (I), (Ia) or (Ib), R 5 -OR 8 , -NR 9 R 10 , -NR 8 C(=O)R 7 , or one or more of oxo, deuterium, halogen, -CN, -OR b , -NR c R d , -C(=O)R a , -C(=O)OR b , -C(=O)NR c R d , C 1- C6 alkyl or C 1- It is an aryl optionally substituted with a C6 haloalkyl.

[0058] In some embodiments of compounds of Formula (I), (Ia) or (Ib), R 5 -OR 8 , -NR 9 R 10 , -NR 8 C(=O)R 7 , cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; wherein each of the cycloalkyl, heterocycloalkyl, aryl, and heteroaryl independently represents one or more of oxo, deuterium, halogen, —CN, —OR b , -NR c R d , -C(=O)R a , -C(=O)OR b , -C(=O)NR c R d ,C 1- C6 alkyl or C 1- In some embodiments of compounds of Formula (I), (Ia) or (Ib), R 5 is -NR 8 C(=O)R 7 In some embodiments of compounds of Formula (I), (Ia) or (Ib), R 5is one or more of oxo, deuterium, halogen, -CN, -OR b , -NR c R d , -C(=O)R a , -C(=O)OR b , -C(=O)NR c R d , C1-C6 alkyl, or C1-C6 haloalkyl.

[0059] In some embodiments of compounds of Formula (I), (Ia) or (Ib), R 7 is C-C alkyl, C-C haloalkyl, C-C deuterated alkyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; wherein each of the alkyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl is independently optionally substituted with one or more oxo, deuterium, halogen, —CN, —OH, —OMe, —NH, —C(═O)Me, —C(═O)OH, —C(═O)OMe, C-C alkyl, or C-C haloalkyl. In some embodiments of compounds of Formula (I), (Ia), or (Ib), R 7 is C-C alkyl, C-C haloalkyl, C-C deuterated alkyl, or cycloalkyl; wherein each of the alkyl, cycloalkyl, and heterocycloalkyl is independently optionally substituted with one or more oxo, deuterium, halogen, —CN, —OH, —OMe, —NH, —C(═O)Me, —C(═O)OH, —C(═O)OMe, C-C alkyl, or C-C haloalkyl. In some embodiments of compounds of Formula (I), (Ia), or (Ib), R 7 is cycloalkyl optionally substituted with one or more oxo, deuterium, halogen, —CN, —OH, —OMe, —NH, —C(═O)Me, —C(═O)OH, —C(═O)OMe, C-C alkyl, or C-C haloalkyl. In some embodiments of compounds of Formula (I), (Ia), or (Ib), R 7 is an unsubstituted cycloalkyl.

[0060] In some embodiments of compounds of Formula (I), (Ia) or (Ib), R 8 is hydrogen, C-C alkyl, C-C haloalkyl, C-C deuterated alkyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; wherein each of the alkyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl is independently optionally substituted with one or more oxo, deuterium, halogen, —CN, —OH, —OMe, —NH, —C(═O)Me, —C(═O)OH, —C(═O)OMe, C-C alkyl, or C-C haloalkyl. In some embodiments of compounds of Formula (I), (Ia), or (Ib), R 8 is hydrogen, C-C alkyl, C-C haloalkyl, C-C deuterated alkyl, or cycloalkyl; wherein each of alkyl, cycloalkyl, and heterocycloalkyl is independently optionally substituted with one or more oxo, deuterium, halogen, —CN, —OH, —OMe, —NH, —C(═O)Me, —C(═O)OH, —C(═O)OMe, C-C alkyl, or C-C haloalkyl.

[0061] In some embodiments of compounds of Formula (I), (Ia) or (Ib), R 9 and R 10 is independently hydrogen, C-C alkyl, C-C haloalkyl, C-C deuterated alkyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; wherein each of the alkyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl is independently optionally substituted with one or more oxo, deuterium, halogen, —CN, —OH, —OMe, —NH, —C(═O)Me, —C(═O)OH, —C(═O)OMe, C-C alkyl, or C-C haloalkyl. In some embodiments of compounds of Formula (I), (Ia), or (Ib), R 9 and R 10are independently hydrogen, C-C alkyl, C-C haloalkyl, C-C deuterated alkyl, or cycloalkyl; wherein each of alkyl, cycloalkyl, and heterocycloalkyl is independently optionally substituted with one or more oxo, deuterium, halogen, —CN, —OH, —OMe, —NH, —C(═O)Me, —C(═O)OH, —C(═O)OMe, C-C alkyl, or C-C haloalkyl.

[0062] Disclosed herein are compounds of formula (II) or (II') below, or a pharmaceutically acceptable salt, stereoisomer, or solvate thereof: [ka] During the ceremony: R 11 is deuterium, halogen, -CN, -OR b , -SR b , -S(=O)R a , -S(=O)2R a , -NO2, -NR c R d , -NHS(=O)2R a , -S(=O)2NR c R d , -C(=O)R a , -OC(=O)R a , -C(=O)OR b , -OC(=O)OR b , -C(=O)NR c R d , -OC(=O)NR c R d , -NR b C(=O)NR c R d , -NR b C(=O)R a , -NR b C(=O)OR b ,C 1- C6 alkyl, C 1- C6 haloalkyl, C 1- C6 deuterated alkyl, C 1- C6 hydroxyalkyl, C1- C6 amino alkyl, C 2- C6 alkenyl, or C 2- C6 alkynyl; R 1 and R 2 are independently hydrogen, C 1- C6 alkyl, C 1- C6 haloalkyl, C 1- C6 deuterated alkyl, C 1- C6 hydroxyalkyl, C 1- C6 amino alkyl, C 2- C6 alkenyl, or C 2- C6 alkynyl; R 3 is hydrogen, C 1- C6 alkyl, C 1- C6 haloalkyl, or C 1- C6 deuterated alkyl; R 4 is hydrogen, deuterium, halogen, -CN, -OR b , -SR b , -S(=O)R a , -S(=O)2R a , -NO2, -NR c R d , -NHS(=O)2R a , -S(=O)2NR c R d , -C(=O)R a , -OC(=O)R a , -C(=O)OR b , -OC(=O)OR b , -C(=O)NR c R d , -OC(=O)NR c R d , -NR b C(=O)NR c R d , -NR b C(=O)R a , -NR b C(=O)OR b , C 1- C6 alkyl, C 1- C6 haloalkyl, C 1- C6 deuterated alkyl, C1- C6 hydroxyalkyl, C 1- C6 amino alkyl, C 2- C6 alkenyl, or C 2- C6 alkynyl; or R 3 and R 4 together form an optionally substituted ring; L is a bond or -C(=O)-; Ring A is a cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; each of which is selected from the group consisting of one or more R A optionally replaced by; Each R A are independently deuterium, halogen, -CN, -OR b , -SR b , -S(=O)R a , -S(=O)2R a , -NO2, -NR c R d , -NHS(=O)2R a , -S(=O)2NR c R d , -C(=O)R a , -OC(=O)R a , -C(=O)OR b , -OC(=O)OR b , -C(=O)NR c R d , -OC(=O)NR c R d , -NR b C(=O)NR c R d , -NR b C(=O)R a , -NR b C(=O)OR b , C 1- C6 alkyl, C 1- C6 haloalkyl, C 1- C6 deuterated alkyl, C 1- C6 hydroxyalkyl, C 1- C6 amino alkyl, C 2- C6 alkenyl, C 2-C6 alkynyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; wherein each of the alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl independently represents one or more of oxo, deuterium, halogen, -CN, -OR b , -NR c R d , -C(=O)R a , -C(=O)OR b , -C(=O)NR c R d , C 1- C6 alkyl, or C 1- optionally substituted with C6 haloalkyl; or two R on the same carbon A together form oxo; X is -CR x -or-N-; R X is hydrogen, deuterium, halogen, -CN, -OR b , -SR b , -S(=O)R a , -S(=O)2R a , -NO2, -NR c R d , -NHS(=O)2R a , -S(=O)2NR c R d , -C(=O)R a , -OC(=O)R a , -C(=O)OR b , -OC(=O)OR b , -C(=O)NR c R d , -OC(=O)NR c R d , -NR b C(=O)NR c R d , -NR b C(=O)R a , -NR b C(=O)OR b , C 1- C6 alkyl, C 1- C6 haloalkyl, C 1-C6 deuterated alkyl, C 1- C6 hydroxyalkyl, C 1- C6 amino alkyl, C 2- C6 alkenyl, or C 2- C6 alkynyl, R 5 is halogen, -CN, -OR 8 , -SR 8 , -S(=O)R 7 , -S(=O)2R 7 , -NO2, -NR 9 R 10 , -NHS(=O)2R 7 , -S(=O)2NR 9 R 10 , -C(=O)R 7 , -OC(=O)R 7 , -C(=O)OR 8 , -OC(=O)OR 8 , -C(=O)NR 9 R 10 , -OC(=O)NR 9 R 10 , -NR 8 C(=O)NR 9 R 10 , -NR 8 C(=O)R 7 , -NR 8 C(=O)OR 8 ,C 1- C6 alkyl, C 1- C6 haloalkyl, C 1- C6 deuterated alkyl, C 1- C6 hydroxyalkyl, C 1- C6 amino alkyl, C 2- C6 alkenyl, C 2- C6 alkynyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; wherein each of the alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl independently represents one or more of oxo, deuterium, halogen, -CN, -OR b , -NR c R d , -C(=O)R a , -C(=O)ORb , -C(=O)NR c R d ,C 1- C6 alkyl, or C 1- optionally substituted with C6 haloalkyl; or R X and R 5 together with one or more R D forming a ring D optionally substituted with; Ring D is cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; Each R D are independently hydrogen, deuterium, halogen, -CN, -OR b , -SR b , -S(=O)R a , -S(=O)2R a , -NO2, -NR c R d , -NHS(=O)2R a , -S(=O)2NR c R d , -C(=O)R a , -OC(=O)R a , -C(=O)OR b , -OC(=O)OR b , -C(=O)NR c R d , -OC(=O)NR c R d , -NR b C(=O)NR c R d , -NR b C(=O)R a , -NR b C(=O)OR b , C 1- C6 alkyl, C 1- C6 haloalkyl, C 1- C6 deuterated alkyl, C 1- C6 hydroxyalkyl, C 1- C6 amino alkyl, C 2- C6 alkenyl, C 2-C6 alkynyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; wherein each of the alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl independently represents one or more of oxo, deuterium, halogen, -CN, -OR b , -NR c R d , -C(=O)R a , -C(=O)OR b , -C(=O)NR c R d , C 1- C6 alkyl, or C 1- optionally substituted with C6 haloalkyl; or two R on the same carbon D together form oxo; R 7 is C 1- C6 alkyl, C 1- C6 haloalkyl, C 1- C6 deuterated alkyl, C 1- C6 hydroxyalkyl, C 1- C6 amino alkyl, C 2- C6 alkenyl, C 2- C alkynyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; in this case, each of the alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl independently represents one or more of oxo, deuterium, halogen, —CN, —OH, —OMe, —NH2, —C(═O)Me, —C(═O)OH, —C(═O)OMe, C 1- C6 alkyl, or C 1- optionally substituted with C6 haloalkyl; Each R 8 are independently hydrogen, C 1- C6 alkyl, C 1- C6 haloalkyl, C 1- C6 deuterated alkyl, C 1- C6 hydroxyalkyl, C 1- C6 amino alkyl, C 2- C6 alkenyl, C 2-C alkynyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; wherein each of the alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl independently represents one or more of oxo, deuterium, halogen, —CN, —OH, —OMe, —NH, —C(═O)Me, —C(═O)OH, —C(═O)OMe, —C 1- C6 alkyl, or C 1- optionally substituted with C6 haloalkyl; R 9 and R 10 are independently hydrogen, C 1- C6 alkyl, C 1- C6 haloalkyl, C 1- C6 deuterated alkyl, C 1- C6 hydroxyalkyl, C 1- C6 amino alkyl, C 2- C6 alkenyl, C 2- C alkynyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; wherein each of the alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl independently represents one or more of oxo, deuterium, halogen, —CN, —OH, —OMe, —NH, —C(═O)Me, —C(═O)OH, —C(═O)OMe, C 1- C6 alkyl, or C 1- optionally substituted with C6 haloalkyl; or R 9 and R 10 together with the nitrogen atom to which they are attached, one or more of oxo, deuterium, halogen, -CN, -OH, -OMe, -NH2, -C(=O)Me, -C(=O)OH, -C(=O)OMe, C 1- C6 alkyl, or C 1- forming a heterocycloalkyl optionally substituted with C6 haloalkyl; Each R a independently, C 1- C6 alkyl, C 1- C6 haloalkyl, C 1-C6 deuterated alkyl, C 1- C6 hydroxyalkyl, C 1- C6 amino alkyl, C 2- C6 alkenyl, C 2- C alkynyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; wherein each of alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl independently represents one or more of oxo, deuterium, halogen, —CN, —OH, —OMe, —NH, —C(═O)Me, —C(═O)OH, —C(═O)OMe, C 1- C6 alkyl, or C 1- optionally substituted with C6 haloalkyl; Each R b are independently hydrogen, C 1- C6 alkyl, C 1- C6 haloalkyl, C 1- C6 deuterated alkyl, C 1- C6 hydroxyalkyl, C 1- C6 amino alkyl, C 2- C6 alkenyl, C 2- C alkynyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; wherein each of the alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl independently represents one or more of oxo, deuterium, halogen, —CN, —OH, —OMe, —NH, —C(═O)Me, —C(═O)OH, —C(═O)OMe, C 1- C6 alkyl, or C 1- optionally substituted with C6 haloalkyl; Each R c and R d are independently hydrogen, C 1- C6 alkyl, C 1- C6 haloalkyl, C 1- C6 deuterated alkyl, C 1- C6 hydroxyalkyl, C 1- C6 amino alkyl, C 2- C6 alkenyl, C 2-C alkynyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; wherein each of the alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl independently represents one or more of oxo, deuterium, halogen, —CN, —OH, —OMe, —NH, —C(═O)Me, —C(═O)OH, —C(═O)OMe, C 1- C6 alkyl, or C 1- optionally substituted with C6 haloalkyl; or R c and R d together with the nitrogen atom to which they are attached, one or more of oxo, deuterium, halogen, -CN, -OH, -OMe, -NH2, -C(=O)Me, -C(=O)OH, -C(=O)OMe, C 1- C6 alkyl, or C 1- Forms a heterocycloalkyl optionally substituted with C6 haloalkyl.

[0063] In some embodiments of the compound of Formula (II) or (II'), L is a bond. In some embodiments of the compound of Formula (II) or (II'), L is -C(=O)-.

[0064] In some embodiments of compounds of Formula (II) or (II'), ring A is heterocycloalkyl or heteroaryl; each of which contains one or more R A In some embodiments of compounds of Formula (II) or (II'), ring A is a 5-membered heterocycloalkyl or a 5-membered heteroaryl; each optionally substituted with one or more R A In some embodiments of compounds of Formula (II) or (II'), ring A is optionally substituted with one or more R A is heteroaryl optionally substituted with

[0065] In some embodiments of compounds of Formula (II) or (II'), each R A are independently deuterium, halogen, -CN, -OR b , -NR c Rd , -C(=O)R a , -C(=O)OR b , -C(=O)NR c R d , -OC(=O)NR c R d , C 1- C6 alkyl, C 1- C6 haloalkyl, or C 1- In some embodiments of compounds of Formula (II) or (II'), each R A is independently deuterium, halogen, C1-C6 alkyl, C1-C6 haloalkyl, or C1-C6 deuterated alkyl. In some embodiments of compounds of Formula (II) or (II'), each R A is independently halogen or C1-C6 alkyl. In some embodiments of compounds of Formula (II) or (II'), each R A are independently C1-C6 alkyl.

[0066] In some embodiments of compounds of Formula (II) or (II'), R 4 is hydrogen, deuterium, halogen, -CN, -OR b , -NR c R d , -C(=O)R a , -C(=O)OR b , -C(=O)NR c R d , -OC(=O)NR c R d , C1-C6 alkyl, C1-C6 haloalkyl, or C1-C6 deuterated alkyl. In some embodiments of compounds of Formula (II) or (II'), R 4 is hydrogen or -OR b In some embodiments of compounds of Formula (II) or (II'), R 4 -OR b In some embodiments of compounds of Formula (II) or (II'), R 4 is hydrogen.

[0067] In some embodiments of the compound of Formula (II) or (II'), X is -CH-. In some embodiments of the compound of Formula (II) or (II'), X is -N-.

[0068] In some embodiments of the compound of Formula (II) or Formula (II'), the compound is a compound of Formula (IIa) or Formula (II'a): [ka]

[0069] In some embodiments of the compound of Formula (II) or Formula (II'), the compound is a compound of Formula (IIb) or Formula (II'b): [ka]

[0070] In some embodiments of compounds of Formula (II), (II'), (IIa), (II'a), (IIb), or (II'b), R 3 is hydrogen or C1-C6 alkyl. In some embodiments of compounds of Formula (II), (II'), (IIa), (II'a), (IIb), or (II'b), R 3 is hydrogen.

[0071] In some embodiments of compounds of Formula (II), (II'), (IIa), (II'a), (IIb), or (II'b), R 1 and R 2 is independently hydrogen, C-C alkyl, C-C haloalkyl, or C-C deuterated alkyl. In some embodiments of compounds of Formula (II), (II'), (IIa), (II'a), (IIb), or (II'b), R 1 and R 2 is independently hydrogen, or C-C deuterated alkyl. In some embodiments of compounds of Formula (II), (II'), (IIa), (II'a), (IIb), or (II'b), R 1is hydrogen. In some embodiments of compounds of Formula (II), (II'), (IIa), (II'a), (IIb), or (II'b), R 2 is C1-C6 alkyl, or C1-C6 deuterated alkyl. In some embodiments of compounds of Formula (II), (II'), (IIa), (II'a), (IIb), or (II'b), R 2 is a C1-C6 deuterated alkyl.

[0072] In some embodiments of compounds of Formula (II), (II'), (IIa), (II'a), (IIb), or (II'b), R 5 is halogen, -CN, -OR 8 , -NR 9 R 10 , -C(=O)R 7 , -C(=O)OR 8 , -C(=O)NR 9 R 10 , -NR 8 C(=O)NR 9 R 10 , -NR 8 C(=O)R 7 , -NR 8 C(=O)OR 8 ,,C 1- C6 alkyl, C 1- C6 haloalkyl, C 1- C6 deuterated alkyl, C 2- C6 alkenyl, C 2- C alkynyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; wherein each of the alkyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl independently represents one or more of oxo, deuterium, halogen, -CN, -OR b , -NR c R d , -C(=O)R a , -C(=O)OR b , -C(=O)NR c R d ,C 1- C6 alkyl, or C 1- Optionally substituted with C6 haloalkyl.

[0073] In some embodiments of compounds of Formula (II), (II'), (IIa), (II'a), (IIb), or (II'b), R 5 -OR 8 , -NR 9 R 10 , -C(=O)R 7 , -C(=O)OR 8 , -C(=O)NR 9 R 10 , -NR 8 C(=O)NR 9 R 10 , -NR 8 C(=O)R 7 , -NR 8 C(=O)OR 8 , cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; wherein each of cycloalkyl, heterocycloalkyl, aryl, and heteroaryl independently represents one or more of oxo, deuterium, halogen, —CN, —OR b , -NR c R d , -C(=O)R a , -C(=O)OR b , -C(=O)NR c R d , C1-C6 alkyl, or C1-C6 haloalkyl.

[0074] In some embodiments of compounds of Formula (II), (II'), (IIa), (II'a), (IIb), or (II'b), R 5 -OR 8 , -NR 9 R 10 , -NR 8 C(=O)R 7 , or one or more of oxo, deuterium, halogen, -CN, -OR b , -NR c R d , -C(=O)R a , -C(=O)OR b , -C(=O)NR c R d, C1-C6 alkyl, or C1-C6 haloalkyl.

[0075] In some embodiments of compounds of Formula (II), (II'), (IIa), (II'a), (IIb), or (II'b), R 5 -OR 8 , -NR 9 R 10 , -NR 8 C(=O)R 7 , cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; wherein each of the cycloalkyl, heterocycloalkyl, aryl, and heteroaryl independently represents one or more of oxo, deuterium, halogen, —CN, —OR b , -NR c R d , -C(=O)R a , -C(=O)OR b , -C(=O)NR c R d In some embodiments of compounds of Formula (II), (II'), (IIa), (II'a), (IIb), or (II'b), R 5 is -NR 8 C(=O)R 7 In some embodiments of compounds of Formula (II), (II'), (IIa), (II'a), (IIb), or (II'b), R 5 is one or more of oxo, deuterium, halogen, -CN, -OR b , -NR c R d , -C(=O)R a , -C(=O)OR b , -C(=O)NR c R d , aryl optionally substituted with C1-C6 alkyl or C1-C6 haloalkyl.

[0076] In some embodiments of compounds of Formula (II), (II'), (IIa), (II'a), (IIb), or (II'b), R 7is C-C alkyl, C-C haloalkyl, C-C deuterated alkyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; wherein each of the alkyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl is independently optionally substituted with one or more oxo, deuterium, halogen, —CN, —OH, —OMe, —NH, —C(═O)Me, —C(═O)OH, —C(═O)OMe, C-C alkyl, or C-C haloalkyl. In some embodiments of compounds of Formula (II), (II′), (IIa), (II′a), (IIb), or (II′b), R 7 is C-C alkyl, C-C haloalkyl, C-C deuterated alkyl, or cycloalkyl; wherein each of the alkyl, cycloalkyl, and heterocycloalkyl is independently optionally substituted with one or more oxo, deuterium, halogen, —CN, —OH, —OMe, —NH, —C(═O)Me, —C(═O)OH, —C(═O)OMe, C-C alkyl, or C-C haloalkyl. In some embodiments of compounds of Formula (II), (II′), (IIa), (II′a), (IIb), or (II′b), R 7 is cycloalkyl optionally substituted with one or more oxo, deuterium, halogen, -CN, -OH, -OMe, -NH, -C(=O)Me, -C(=O)OH, -C(=O)OMe, C-C alkyl, or C-C haloalkyl. In some embodiments of compounds of Formula (II), (II'), (IIa), (II'a), (IIb), or (II'b), R 7 is an unsubstituted cycloalkyl.

[0077] In some embodiments of compounds of Formula (II), (II'), (IIa), (II'a), (IIb), or (II'b), R 8is hydrogen, C-C alkyl, C-C haloalkyl, C-C deuterated alkyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; wherein each of the alkyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl is independently optionally substituted with one or more oxo, deuterium, halogen, —CN, —OH, —OMe, —NH, —C(═O)Me, —C(═O)OH, —C(═O)OMe, C-C alkyl, or C-C haloalkyl. In some embodiments of compounds of Formula (II), (II′), (IIa), (II′a), (IIb), or (II′b), R 8 is hydrogen, C-C alkyl, C-C haloalkyl, C-C deuterated alkyl, or cycloalkyl; wherein each of alkyl, cycloalkyl, and heterocycloalkyl is independently optionally substituted with one or more oxo, deuterium, halogen, —CN, —OH, —OMe, —NH, —C(═O)Me, —C(═O)OH, —C(═O)OMe, C-C alkyl, or C-C haloalkyl.

[0078] In some embodiments of compounds of Formula (II), (II'), (IIa), (II'a), (IIb), or (II'b), R 9 and R 10 is independently hydrogen, C-C alkyl, C-C haloalkyl, C-C deuterated alkyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; wherein each of the alkyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl is independently optionally substituted with one or more oxo, deuterium, halogen, —CN, —OH, —OMe, —NH, —C(═O)Me, —C(═O)OH, —C(═O)OMe, C-C alkyl, or C-C haloalkyl. In some embodiments of compounds of Formula (II), (II′), (IIa), (II′a), (IIb), or (II′b), R 9 and R 10are independently hydrogen, C-C alkyl, C-C haloalkyl, C-C deuterated alkyl, or cycloalkyl; wherein each of alkyl, cycloalkyl, and heterocycloalkyl is independently optionally substituted with one or more oxo, deuterium, halogen, —CN, —OH, —OMe, —NH, —C(═O)Me, —C(═O)OH, —C(═O)OMe, C-C alkyl, or C-C haloalkyl.

[0079] In some embodiments of compounds of Formula (II), (II'), (IIa), (II'a), (IIb), or (II'b), R 11 is deuterium, halogen, -CN, -OR b , -NR c R d , -C(=O)R a , -C(=O)OR b , -C(=O)NR c R d , C 1- C6 alkyl, C 1- C6 haloalkyl, or C 1- In some embodiments of compounds of Formula (II), (II'), (IIa), (II'a), (IIb), or (II'b), R 11 is deuterium, halogen, C-C alkyl, C-C haloalkyl, or C-C deuterated alkyl. In some embodiments of compounds of Formula (II), (II'), (IIa), (II'a), (IIb), or (II'b), R 11 is halogen. In some embodiments of compounds of Formula (II), (II'), (IIa), (II'a), (IIb), or (II'b), R 11 is hydrogen.

[0080] Disclosed herein are compounds of formula (III) below, or a pharmaceutically acceptable salt, stereoisomer, or solvate thereof: [ka] During the ceremony: Ring B is cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; provided that: [ka] rather than; Each R B are independently hydrogen, deuterium, halogen, -CN, -OR b , -SR b , -S(=O)R a , -S(=O)2R a , -NO2, -NR c R d , -NHS(=O)2R a , -S(=O)2NR c R d , -C(=O)R a , -OC(=O)R a , -C(=O)OR b , -OC(=O)OR b , -C(=O)NR c R d , -OC(=O)NR c R d , -NR b C(=O)NR c R d , -NR b C(=O)R a , -NR b C(=O)OR b ,C 1- C6 alkyl, C 1- C6 haloalkyl, C 1- C6 deuterated alkyl, C 1- C6 hydroxyalkyl, C 1- C6 amino alkyl, C 2- C6 alkenyl, or C 2- C6 alkynyl; or two R on the same carbon B together form oxo; or two R on adjacent atoms B together form a cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; each of which may be one or more of deuterium, oxo, halogen, -CN, -OR b , -NRc R d , -C(=O)R a , -C(=O)OR b , -C(=O)NR c R d , C 1- C6 alkyl, C 1- C6 deuterated alkyl, or C 1- optionally substituted with C6 haloalkyl; n is 0 to 4; each Y is independently C or N; R 3 is hydrogen, C 1- C6 alkyl, C 1- C6 haloalkyl, or C 1- C6 deuterated alkyl; R 4 is hydrogen, deuterium, halogen, -CN, -OR b , -SR b , -S(=O)R a , -S(=O)2R a , -NO2, -NR c R d , -NHS(=O)2R a , -S(=O)2NR c R d , -C(=O)R a , -OC(=O)R a , -C(=O)OR b , -OC(=O)OR b , -C(=O)NR c R d , -OC(=O)NR c R d , -NR b C(=O)NR c R d , -NR b C(=O)R a , -NR b C(=O)OR b ,C 1- C6 alkyl, C 1- C6 haloalkyl, C 1- C6 deuterated alkyl, C 1- C6 hydroxyalkyl, C 1- C6 amino alkyl, C 2-C6 alkenyl, or C 2- C6 alkynyl; or R 3 and R 4 together form an optionally substituted ring; L is a bond or -C(=O)-; Ring A is a cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; each of which is selected from the group consisting of one or more R A optionally replaced by; Each R A are independently deuterium, halogen, -CN, -OR b , -SR b , -S(=O)R a , -S(=O)2R a , -NO2, -NR c R d , -NHS(=O)2R a , -S(=O)2NR c R d , -C(=O)R a , -OC(=O)R a , -C(=O)OR b , -OC(=O)OR b , -C(=O)NR c R d , -OC(=O)NR c R d , -NR b C(=O)NR c R d , -NR b C(=O)R a , -NR b C(=O)OR b , C 1- C6 alkyl, C 1- C6 haloalkyl, C 1- C6 deuterated alkyl, C 1- C6 hydroxyalkyl, C 1- C6 amino alkyl, C 2- C6 alkenyl, C 2-C6 alkynyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; wherein each of the alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl independently represents one or more of oxo, deuterium, halogen, -CN, -OR b , -NR c R d , -C(=O)R a , -C(=O)OR b , -C(=O)NR c R d , C 1- C6 alkyl, or C 1- optionally substituted with C6 haloalkyl; or two R on the same carbon A together form oxo; X is -CR x -or-N-; R X is hydrogen, deuterium, halogen, -CN, -OR b , -SR b , -S(=O)R a , -S(=O)2R a , -NO2, -NR c R d , -NHS(=O)2R a , -S(=O)2NR c R d , -C(=O)R a , -OC(=O)R a , -C(=O)OR b , -OC(=O)OR b , -C(=O)NR c R d , -OC(=O)NR c R d , -NR b C(=O)NR c R d , -NR b C(=O)R a , -NR b C(=O)OR b ,C 1- C6 alkyl, C 1- C6 haloalkyl, C 1-C6 deuterated alkyl, C 1- C6 hydroxyalkyl, C 1- C6 amino alkyl, C 2- C6 alkenyl, or C 2- C6 alkynyl; R 5 is halogen, -CN, -OR 8 , -SR 8 , -S(=O)R 7 , -S(=O)2R 7 , -NO2, -NR 9 R 10 , -NHS(=O)2R 7 , -S(=O)2NR 9 R 10 , -C(=O)R 7 , -OC(=O)R 7 , -C(=O)OR 8 , -OC(=O)OR 8 , -C(=O)NR 9 R 10 , -OC(=O)NR 9 R 10 , -NR 8 C(=O)NR 9 R 10 , -NR 8 C(=O)R 7 , -NR 8 C(=O)OR 8 , C 1- C6 alkyl, C 1- C6 haloalkyl, C 1- C6 deuterated alkyl, C 1- C6 hydroxyalkyl, C 1- C6 amino alkyl, C 2- C6 alkenyl, C 2- C6 alkynyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; wherein each of the alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl independently represents one or more of oxo, deuterium, halogen, -CN, -OR b , -NR c R d , -C(=O)R a , -C(=O)ORb , -C(=O)NR c R d ,,C 1- C6 alkyl, or C 1- optionally substituted with C6 haloalkyl; or R X and R 5 together with one or more R D forming a ring D optionally substituted with; Ring D is cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; Each R D are independently hydrogen, deuterium, halogen, -CN, -OR b , -SR b , -S(=O)R a , -S(=O)2R a , -NO2, -NR c R d , -NHS(=O)2R a , -S(=O)2NR c R d , -C(=O)R a , -OC(=O)R a , -C(=O)OR b , -OC(=O)OR b , -C(=O)NR c R d , -OC(=O)NR c R d , -NR b C(=O)NR c R d , -NR b C(=O)R a , -NR b C(=O)OR b , C 1- C6 alkyl, C 1- C6 haloalkyl, C 1- C6 deuterated alkyl, C 1- C6 hydroxyalkyl, C 1- C6 amino alkyl, C 2- C6 alkenyl, C 2-C6 alkynyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; wherein each of the alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl independently represents one or more of oxo, deuterium, halogen, -CN, -OR b , -NR c R d , -C(=O)R a , -C(=O)OR b , -C(=O)NR c R d ,,C 1- C6 alkyl, or C 1- optionally substituted with C6 haloalkyl; or two R on the same carbon D together form oxo; R 7 is C 1- C6 alkyl, C 1- C6 haloalkyl, C 1- C6 deuterated alkyl, C 1- C6 hydroxyalkyl, C 1- C6 amino alkyl, C 2- C6 alkenyl, C 2- C alkynyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; wherein each of the alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl independently represents one or more of oxo, deuterium, halogen, —CN, —OH, —OMe, —NH, —C(═O)Me, —C(═O)OH, —C(═O)OMe, C 1- C6 alkyl, or C 1- optionally substituted with C6 haloalkyl; Each R 8 are independently hydrogen, C 1- C6 alkyl, C 1- C6 haloalkyl, C 1- C6 deuterated alkyl, C 1- C6 hydroxyalkyl, C 1- C6 amino alkyl, C 2- C6 alkenyl, C 2-C alkynyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; wherein each of the alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl independently represents one or more of oxo, deuterium, halogen, —CN, —OH, —OMe, —NH, —C(═O)Me, —C(═O)OH, —C(═O)OMe, C 1- C6 alkyl, or C 1- optionally substituted with C6 haloalkyl; R 9 and R 10 are independently hydrogen, C 1- C6 alkyl, C 1- C6 haloalkyl, C 1- C6 deuterated alkyl, C 1- C6 hydroxyalkyl, C 1- C6 amino alkyl, C 2- C6 alkenyl, C 2- C alkynyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; wherein each of the alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl independently represents one or more of oxo, deuterium, halogen, —CN, —OH, —OMe, —NH, —C(═O)Me, —C(═O)OH, —C(═O)OMe, C 1- C6 alkyl, or C 1- optionally substituted with C6 haloalkyl; or R 9 and R 10 together with the nitrogen atom to which they are attached, one or more of oxo, deuterium, halogen, -CN, -OH, -OMe, -NH2, -C(=O)Me, -C(=O)OH, -C(=O)OMe, C 1- C6 alkyl, or C 1- forming a heterocycloalkyl optionally substituted with C6 haloalkyl; Each R a independently, C 1- C6 alkyl, C 1- C6 haloalkyl, C 1- C6 deuterated alkyl, C1- C6 hydroxyalkyl, C 1- C6 amino alkyl, C 2- C6 alkenyl, C 2- C alkynyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; wherein each of the alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl independently represents one or more of oxo, deuterium, halogen, —CN, —OH, —OMe, —NH, —C(═O)Me, —C(═O)OH, —C(═O)OMe, C 1- C6 alkyl, or C 1- optionally substituted with C6 haloalkyl; Each R b are independently hydrogen, C 1- C6 alkyl, C 1- C6 haloalkyl, C 1- C6 deuterated alkyl, C 1- C6 hydroxyalkyl, C 1- C6 amino alkyl, C 2- C6 alkenyl, C 2- C alkynyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; wherein each of alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl independently may be one or more of oxo, deuterium, halogen, -CN, -OH, -OMe, -NH2, -C(=O)Me, -C(=O)OH, -C(=O)OMe, C 1- C6 alkyl, or C 1- optionally substituted with C6 haloalkyl; Each R c and R d are independently hydrogen, C 1- C6 alkyl, C 1- C6 haloalkyl, C 1- C6 deuterated alkyl, C 1- C6 hydroxyalkyl, C 1- C6 amino alkyl, C 2- C6 alkenyl, C 2-C alkynyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; wherein each of the alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl independently represents one or more of oxo, deuterium, halogen, —CN, —OH, —OMe, —NH, —C(═O)Me, —C(═O)OH, —C(═O)OMe, C 1- C6 alkyl, or C 1- optionally substituted with C6 haloalkyl; or R c and R d together with the nitrogen atom to which they are attached, one or more of oxo, deuterium, halogen, -CN, -OH, -OMe, -NH2, -C(=O)Me, -C(=O)OH, -C(=O)OMe, C 1- C6 alkyl, or C 1- Forms a heterocycloalkyl optionally substituted with C6 haloalkyl.

[0081] In some embodiments of the compound of Formula (III), L is a bond. In some embodiments of the compound of Formula (III), L is -C(=O)-.

[0082] In some embodiments of compounds of Formula (III), ring A is heterocycloalkyl or heteroaryl; each of which contains one or more R A In some embodiments of compounds of Formula (III), ring A is a 5-membered heterocycloalkyl or a 5-membered heteroaryl; each optionally substituted with one or more R A In some embodiments of the compound of Formula (III), ring A is optionally substituted with one or more R A is heteroaryl optionally substituted with

[0083] In some embodiments of the compound of Formula (III), each R A are independently deuterium, halogen, -CN, -OR b , -NR c R d , -C(=O)R a , -C(=O)ORb , -C(=O)NR c R d , -OC(=O)NR c R d , C 1- C6 alkyl, C 1- C6 haloalkyl, or C 1- In some embodiments of the compound of Formula (III), each R A is independently deuterium, halogen, C-C alkyl, C-C haloalkyl, or C-C deuterated alkyl. In some embodiments of compounds of Formula (III), each R A is independently halogen or C1-C6 alkyl. In some embodiments of compounds of Formula (III), each R A are independently C1-C6 alkyl.

[0084] In some embodiments of the compound of Formula (III), R 4 is hydrogen, deuterium, halogen, -CN, -OR b , -NR c R d , -C(=O)R a , -C(=O)OR b , -C(=O)NR c R d , -OC(=O)NR c R d , C 1- C6 alkyl, C 1- C6 haloalkyl, or C 1- In some embodiments of the compound of formula (III), R 4 is hydrogen or -OR b In some embodiments of the compound of Formula (III), R 4 -OR b In some embodiments of the compound of Formula (III), R 4 is hydrogen.

[0085] In some embodiments of the compound of Formula (III), X is -CH-. In some embodiments of the compound of Formula (III), X is -N-.

[0086] In some embodiments of the compound of Formula (III), the compound is a compound of Formula (IIIa): [ka]

[0087] In some embodiments of the compound of Formula (III), the compound is a compound of Formula (IIIb): [ka]

[0088] In some embodiments of compounds of Formula (III), (IIIa) or (IIIb), R 3 is hydrogen or C1-C6 alkyl. In some embodiments of compounds of Formula (III), (IIIa) or (IIIb), R 3 is hydrogen.

[0089] In some embodiments of compounds of Formula (III), (IIIa) or (IIIb), R 5 is halogen, -CN, -OR 8 , -NR 9 R 10 , -C(=O)R 7 , -C(=O)OR 8 , -C(=O)NR 9 R 10 , -NR 8 C(=O)NR 9 R 10 , -NR 8 C(=O)R 7 , -NR 8 C(=O)OR 8 , , C 1- C6 alkyl, C 1- C6 haloalkyl, C 1- C6 deuterated alkyl, C 2- C6 alkenyl, C 2-C alkynyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; wherein each of the alkyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl independently represents one or more of oxo, deuterium, halogen, -CN, -OR b , -NR c R d , -C(=O)R a , -C(=O)OR b , -C(=O)NR c R d , C 1- C6 alkyl, or C 1- Optionally substituted with C6 haloalkyl.

[0090] In some embodiments of compounds of Formula (III), (IIIa), or (IIIb), R 5 -OR 8 , -NR 9 R 10 , -C(=O)R 7 , -C(=O)OR 8 , -C(=O)NR 9 R 10 , -NR 8 C(=O)NR 9 R 10 , -NR 8 C(=O)R 7 , -NR 8 C(=O)OR 8 , cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; wherein each of the cycloalkyl, heterocycloalkyl, aryl, and heteroaryl independently represents one or more of oxo, deuterium, halogen, —CN, —OR b , -NR c R d , -C(=O)R a , -C(=O)OR b , -C(=O)NR c R d , C1-C6 alkyl, or C1-C6 haloalkyl.

[0091] In some embodiments of compounds of Formula (III), (IIIa) or (IIIb), R 5 -OR 8 , -NR 9 R 10 , -NR 8 C(=O)R 7 , or one or more of oxo, deuterium, halogen, -CN, -OR b , -NR c R d , -C(=O)R a , -C(=O)OR b , -C(=O)NR c R d , C1-C6 alkyl, or aryl optionally substituted with C1-C6 haloalkyl.

[0092] In some embodiments of compounds of Formula (III), (IIIa), or (IIIb), R 5 -OR 8 , -NR 9 R 10 , -NR 8 C(=O)R 7 , cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; wherein each of the cycloalkyl, heterocycloalkyl, aryl, and heteroaryl independently represents one or more of oxo, deuterium, halogen, —CN, —OR b , -NR c R d , -C(=O)R a , -C(=O)OR b , -C(=O)NR c R d , C1-C6 alkyl, or C1-C6 haloalkyl. In some embodiments of compounds of Formula (III), (IIIa), or (IIIb), R 5 is -NR 8 C(=O)R 7 In some embodiments of compounds of Formula (III), (IIIa) or (IIIb), R 5 is one or more of oxo, deuterium, halogen, -CN, -OR b , -NR c Rd , -C(=O)R a , -C(=O)OR b , -C(=O)NR c R d , C1-C6 alkyl, or C1-C6 haloalkyl.

[0093] In some embodiments of compounds of Formula (III), (IIIa) or (IIIb), R 7 is C-C alkyl, C-C haloalkyl, C-C deuterated alkyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; wherein each of the alkyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl is independently optionally substituted with one or more oxo, deuterium, halogen, —CN, —OH, —OMe, —NH, —C(═O)Me, —C(═O)OH, —C(═O)OMe, C-C alkyl, or C-C haloalkyl. In some embodiments of compounds of Formula (III), (IIIa), or (IIIb), R 7 is C-C alkyl, C-C haloalkyl, C-C deuterated alkyl, or cycloalkyl; wherein each of the alkyl, cycloalkyl, and heterocycloalkyl is independently optionally substituted with one or more oxo, deuterium, halogen, —CN, —OH, —OMe, —NH, —C(═O)Me, —C(═O)OH, —C(═O)OMe, C-C alkyl, or C-C haloalkyl. In some embodiments of compounds of Formula (III), (IIIa), or (IIIb), R 7 is cycloalkyl optionally substituted with one or more oxo, deuterium, halogen, —CN, —OH, —OMe, —NH, —C(═O)Me, —C(═O)OH, —C(═O)OMe, C-C alkyl, or C-C haloalkyl. In some embodiments of compounds of Formula (III), (IIIa), or (IIIb), R 7 is an unsubstituted cycloalkyl.

[0094] In some embodiments of compounds of Formula (III), (IIIa) or (IIIb), R 8 is hydrogen, C-C alkyl, C-C haloalkyl, C-C deuterated alkyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; wherein each of the alkyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl is independently optionally substituted with one or more oxo, deuterium, halogen, —CN, —OH, —OMe, —NH, —C(═O)Me, —C(═O)OH, —C(═O)OMe, C-C alkyl, or C-C haloalkyl. In some embodiments of compounds of Formula (III), (IIIa), or (IIIb), R 8 is hydrogen, C-C alkyl, C-C haloalkyl, C-C deuterated alkyl, or cycloalkyl; wherein each of alkyl, cycloalkyl, and heterocycloalkyl is independently optionally substituted with one or more oxo, deuterium, halogen, —CN, —OH, —OMe, —NH, —C(═O)Me, —C(═O)OH, —C(═O)OMe, C-C alkyl, or C-C haloalkyl.

[0095] In some embodiments of compounds of Formula (III), (IIIa) or (IIIb), R 9 and R 10 is independently hydrogen, C-C alkyl, C-C haloalkyl, C-C deuterated alkyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; wherein each of the alkyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl is independently optionally substituted with one or more oxo, deuterium, halogen, —CN, —OH, —OMe, —NH, —C(═O)Me, —C(═O)OH, —C(═O)OMe, C-C alkyl, or C-C haloalkyl. In some embodiments of compounds of Formula (III), (IIIa), or (IIIb), R 9 and R 10are independently hydrogen, C-C alkyl, C-C haloalkyl, C-C deuterated alkyl, or cycloalkyl; wherein each of alkyl, cycloalkyl, and heterocycloalkyl is independently optionally substituted with one or more oxo, deuterium, halogen, —CN, —OH, —OMe, —NH, —C(═O)Me, —C(═O)OH, —C(═O)OMe, C-C alkyl, or C-C haloalkyl.

[0096] In some embodiments of compounds of Formula (III), (IIIa), or (IIIb), Ring B is heterocycloalkyl or heteroaryl.

[0097] In some embodiments of compounds of Formula (III), (IIIa) or (IIIb), [ka] and n' is 0 to 3.

[0098] In some embodiments of compounds of Formula (III), (IIIa), or (IIIb), each R B are independently hydrogen, deuterium, halogen, -CN, -OR b , -NR c R d , -C(=O)R a , -C(=O)OR b , -C(=O)NR c R d , C 1- C6 alkyl, C 1- C6 haloalkyl, or C 1- C6 deuterated alkyl; or two R on the same carbon B together form oxo. In some embodiments of compounds of Formula (III), (IIIa), or (IIIb), each R B are independently hydrogen, deuterium, halogen, C1-C6 alkyl, C1-C6 haloalkyl, or C1-C6 deuterated alkyl; or two R on the same carbon B together form oxo.

[0099] In some embodiments of compounds of Formula (III), (IIIa), or (IIIb), two R B together form a cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; each of which may be one or more of deuterium, oxo, halogen, -CN, -OR b , -NR c R d , -C(=O)R a , -C(=O)OR b , -C(=O)NR c R d , C 1- C6 alkyl, C 1- C6 deuterated alkyl, or C 1- In some embodiments of compounds of Formula (III), (IIIa), or (IIIb), two R on adjacent atoms are optionally substituted with C haloalkyl. B together form a heterocycloalkyl or heteroaryl; each of which may be one or more of deuterium, oxo, halogen, -CN, -OR b , -NR c R d , -C(=O)R a , -C(=O)OR b , -C(=O)NR c R d , C 1- C6 alkyl, C 1- C6 deuterated alkyl, or C 1- optionally substituted with C6 haloalkyl;

[0100] In some embodiments of a compound of Formula (III), (IIIa) or (IIIb), n is 0. In some embodiments of a compound of Formula (III), (IIIa) or (IIIb), n is 1. In some embodiments of a compound of Formula (III), (IIIa) or (IIIb), n is 2. In some embodiments of a compound of Formula (III), (IIIa) or (IIIb), n is 0 to 2. In some embodiments of a compound of Formula (III), (IIIa) or (IIIb), n is 0 or 1. In some embodiments of a compound of Formula (III), (IIIa) or (IIIb), n is 1 or 2. In some embodiments of a compound of Formula (III), (IIIa) or (IIIb), n is 1 to 3.

[0101] In some embodiments of a compound of Formula (III), (IIIa) or (IIIb), n' is 0. In some embodiments of a compound of Formula (III), (IIIa) or (IIIb), n' is 1. In some embodiments of a compound of Formula (III), (IIIa) or (IIIb), n' is 2. In some embodiments of a compound of Formula (III), (IIIa) or (IIIb), n' is 0 to 2. In some embodiments of a compound of Formula (III), (IIIa) or (IIIb), n' is 0 or 1. In some embodiments of a compound of Formula (III), (IIIa) or (IIIb), n' is 1 or 2.

[0102] Disclosed herein is a compound of formula (IV) below, or a pharmaceutically acceptable salt, stereoisomer, or solvate thereof: [ka] During the ceremony: Ring C is a bicyclic ring system; Each R C are independently hydrogen, oxo, deuterium, halogen, -CN, -OR b , -SR b , -S(=O)R a , -S(=O)2R a , -NO2, -NRc R d , -NHS(=O)2R a , -S(=O)2NR c R d , -C(=O)R a , -OC(=O)R a , -C(=O)OR b , -OC(=O)OR b , -C(=O)NR c R d , -OC(=O)NR c R d , -NR b C(=O)NR c R d , -NR b C(=O)R a , -NR b C(=O)OR b , C 1- C6 alkyl, C 1- C6 haloalkyl, C 1- C6 deuterated alkyl, C 1- C6 hydroxyalkyl, C 1- C6 amino alkyl, C 2- C6 alkenyl, or C 2- C6 alkynyl; m is 0 to 4; R 12 is -C(=O)NR 1 R 2 or -L 1- R 13 and; R 1 and R 2 are independently hydrogen, C 1- C6 alkyl, C 1- C6 haloalkyl, C 1- C6 deuterated alkyl, C 1- C6 hydroxyalkyl, C 1- C6 amino alkyl, C 2- C6 alkenyl, or C 2- C6 alkynyl; L 1 is -O-, -NH-, or -N(CH3)-; R 13 is C 1-C6 alkyl, C 1- C6 haloalkyl, C 1- C6 deuterated alkyl, C 1- C6 hydroxyalkyl, C 1- C6 amino alkyl, C 2- C6 alkenyl, C 2- C6 alkynyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; wherein each of the alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl independently represents one or more of oxo, deuterium, halogen, -CN, -OR b , -NR c R d , -C(=O)R a , -C(=O)OR b , -C(=O)NR c R d , C 1- C6 alkyl, or C 1- optionally substituted with C6 haloalkyl; L is a bond or -C(=O)-; Ring A is a cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; each of which is selected from the group consisting of one or more R A optionally replaced by; Each R A are independently deuterium, halogen, -CN, -OR b , -SR b , -S(=O)R a , -S(=O)2R a , -NO2, -NR c R d , -NHS(=O)2R a , -S(=O)2NR c R d , -C(=O)R a , -OC(=O)R a , -C(=O)OR b , -OC(=O)OR b , -C(=O)NR c R d , -OC(=O)NR c R d , -NR bC(=O)NR c R d , -NR b C(=O)R a , -NR b C(=O)OR b , C1-C6 alkyl, C1-C6 haloalkyl, C1-C6 deuterated alkyl, C1-C6 hydroxyalkyl, C1-C6 aminoalkyl, C2-C6 alkenyl, C2-C6 alkynyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; wherein each of alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl independently represents one or more of oxo, deuterium, halogen, -CN, -OR b , -NR c R d , -C(=O)R a , -C(=O)OR b , -C(=O)NR c R d , optionally substituted with C1-C6 alkyl, or C1-C6 haloalkyl; or two R on the same carbon A together form oxo; X is -CR x -or-N-; R X is hydrogen, deuterium, halogen, -CN, -OR b , -SR b , -S(=O)R a , -S(=O)2R a , -NO2, -NR c R d , -NHS(=O)2R a , -S(=O)2NR c R d , -C(=O)R a , -OC(=O)R a , -C(=O)OR b , -OC(=O)OR b , -C(=O)NR c R d , -OC(=O)NR c R d , -NR bC(=O)NR c R d , -NR b C(=O)R a , -NR b C(=O)OR b , C 1- C6 alkyl, C 1- C6 haloalkyl, C 1- C6 deuterated alkyl, C 1- C6 hydroxyalkyl, C 1- C6 amino alkyl, C 2- C6 alkenyl, or C 2- C6 alkynyl; R 5 is halogen, -CN, -OR 8 , -SR 8 , -S(=O)R 7 , -S(=O)2R 7 , -NO2, -NR 9 R 10 , -NHS(=O)2R 7 , -S(=O)2NR 9 R 10 , -C(=O)R 7 , -OC(=O)R 7 , -C(=O)OR 8 , -OC(=O)OR 8 , -C(=O)NR 9 R 10 , -OC(=O)NR 9 R 10 , -NR 8 C(=O)NR 9 R 10 , -NR 8 C(=O)R 7 , -NR 8 C(=O)OR 8 , C 1- C6 alkyl, C 1- C6 haloalkyl, C 1- C6 deuterated alkyl, C 1- C6 hydroxyalkyl, C 1- C6 amino alkyl, C 2- C6 alkenyl, C 2-C6 alkynyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; wherein each of the alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl independently represents one or more of oxo, deuterium, halogen, -CN, -OR b , -NR c R d , -C(=O)R a , -C(=O)OR b , -C(=O)NR c R d , C 1- C6 alkyl, or C 1- optionally substituted with C6 haloalkyl; or R X and R 5 together with one or more R D forming a ring D optionally substituted with; Ring D is cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; Each R D are independently hydrogen, deuterium, halogen, -CN, -OR b , -SR b , -S(=O)R a , -S(=O)2R a , -NO2, -NR c R d , -NHS(=O)2R a , -S(=O)2NR c R d , -C(=O)R a , -OC(=O)R a , -C(=O)OR b , -OC(=O)OR b , -C(=O)NR c R d , -OC(=O)NR c R d , -NR b C(=O)NR c R d , -NR b C(=O)R a , -NR b C(=O)OR b , C1- C6 alkyl, C 1- C6 haloalkyl, C 1- C6 deuterated alkyl, C 1- C6 hydroxyalkyl, C 1- C6 amino alkyl, C 2- C6 alkenyl, C 2- C6 alkynyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; wherein each of the alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl independently represents one or more of oxo, deuterium, halogen, -CN, -OR b , -NR c R d , -C(=O)R a , -C(=O)OR b , -C(=O)NR c R d ,C 1- C6 alkyl, or C 1- optionally substituted with C6 haloalkyl; or two R on the same carbon D together form oxo; R 7 is C 1- C6 alkyl, C 1- C6 haloalkyl, C 1- C6 deuterated alkyl, C 1- C6 hydroxyalkyl, C 1- C6 amino alkyl, C 2- C6 alkenyl, C 2- C alkynyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; wherein each of the alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl independently represents one or more of oxo, deuterium, halogen, —CN, —OH, —OMe, —NH, —C(═O)Me, —C(═O)OH, —C(═O)OMe, C 1- C6 alkyl, or C 1- optionally substituted with C6 haloalkyl; Each R 8 are independently hydrogen, C 1-C6 alkyl, C 1- C6 haloalkyl, C 1- C6 deuterated alkyl, C 1- C6 hydroxyalkyl, C 1- C6 amino alkyl, C 2- C6 alkenyl, C 2- C alkynyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; wherein each of alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl independently represents one or more of oxo, deuterium, halogen, —CN, —OH, —OMe, —NH, —C(═O)Me, —C(═O)OH, —C(═O)OMe,C 1- C6 alkyl, or C 1- optionally substituted with C6 haloalkyl; R 9 and R 10 are independently hydrogen, C 1- C6 alkyl, C 1- C6 haloalkyl, C 1- C6 deuterated alkyl, C 1- C6 hydroxyalkyl, C 1- C6 amino alkyl, C 2- C6 alkenyl, C 2- C alkynyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; wherein each of the alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl independently represents one or more of oxo, deuterium, halogen, —CN, —OH, —OMe, —NH, —C(═O)Me, —C(═O)OH, —C(═O)OMe, C 1- C6 alkyl, or C 1- optionally substituted with C6 haloalkyl; or R 9 and R 10 together with the nitrogen atom to which they are attached, one or more of oxo, deuterium, halogen, -CN, -OH, -OMe, -NH2, -C(=O)Me, -C(=O)OH, -C(=O)OMe, C 1- C6 alkyl, or C 1-forming a heterocycloalkyl optionally substituted with C6 haloalkyl; Each R a independently, C 1- C6 alkyl, C 1- C6 haloalkyl, C 1- C6 deuterated alkyl, C 1- C6 hydroxyalkyl, C 1- C6 amino alkyl, C 2- C6 alkenyl, C 2- C alkynyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; wherein each of the alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl independently represents one or more of oxo, deuterium, halogen, —CN, —OH, —OMe, —NH, —C(═O)Me, —C(═O)OH, —C(═O)OMe, C 1- C6 alkyl, or C 1- optionally substituted with C6 haloalkyl; Each R b are independently hydrogen, C 1- C6 alkyl, C 1- C6 haloalkyl, C 1- C6 deuterated alkyl, C 1- C6 hydroxyalkyl, C 1- C6 amino alkyl, C 2- C6 alkenyl, C 2- C alkynyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; wherein each of the alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl independently represents one or more of oxo, deuterium, halogen, —CN, —OH, —OMe, —NH, —C(═O)Me, —C(═O)OH, —C(═O)OMe, C 1- C6 alkyl, or C 1- optionally substituted with C6 haloalkyl; Each R c and R d are independently hydrogen, C 1- C6 alkyl, C 1- C6 haloalkyl, C1- C6 deuterated alkyl, C 1- C6 hydroxyalkyl, C 1- C6 amino alkyl, C 2- C6 alkenyl, C 2- C alkynyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; wherein each of alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl independently represents one or more of oxo, deuterium, halogen, —CN, —OH, —OMe, —NH, —C(═O)Me, —C(═O)OH, —C(═O)OMe,C 1- C6 alkyl, or C 1- optionally substituted with C6 haloalkyl; or R c and R d together with the nitrogen atom to which they are attached, one or more of oxo, deuterium, halogen, -CN, -OH, -OMe, -NH2, -C(=O)Me, -C(=O)OH, -C(=O)OMe, C 1- C6 alkyl, or C 1- Forms a heterocycloalkyl optionally substituted with C6 haloalkyl.

[0103] In some embodiments of the compound of Formula (IV), L is a bond. In some embodiments of the compound of Formula (IV), L is -C(=O)-.

[0104] In some embodiments of compounds of Formula (IV), ring A is heterocycloalkyl or heteroaryl; each of which may contain one or more R A In some embodiments of compounds of Formula (IV), ring A is a 5-membered heterocycloalkyl or a 5-membered heteroaryl; each optionally substituted with one or more R A In some embodiments of the compound of Formula (IV), ring A is optionally substituted with one or more R A is heteroaryl optionally substituted with

[0105] In some embodiments of the compound of Formula (IV), each R Aare independently deuterium, halogen, -CN, -OR b , -NR c R d , -C(=O)R a , -C(=O)OR b , -C(=O)NR c R d , -OC(=O)NR c R d , C 1- C6 alkyl, C 1- C6 haloalkyl, or C 1- In some embodiments of the compound of Formula (IV), each R A is independently deuterium, halogen, C1-C6 alkyl, C1-C6 haloalkyl, or C1-C6 deuterated alkyl. In some embodiments of compounds of Formula (IV), each R A is independently halogen or C1-C6 alkyl. In some embodiments of compounds of Formula (IV), each R A are independently C1-C6 alkyl.

[0106] In some embodiments of the compound of Formula (IV), R 4 is hydrogen, deuterium, halogen, -CN, -OR b , -NR c R d , -C(=O)R a , -C(=O)OR b , -C(=O)NR c R d , -OC(=O)NR c R d , C 1- C6 alkyl, C 1- C6 haloalkyl, or C 1- In some embodiments of the compound of formula (IV), R 4 is hydrogen or -OR b In some embodiments of the compound of Formula (IV), R 4 -OR b In some embodiments of the compound of Formula (IV), R 4 is hydrogen.

[0107] In some embodiments of the compound of Formula (IV), X is -CH-. In some embodiments of the compound of Formula (IV), X is -N-.

[0108] In some embodiments of the compound of Formula (IV), the compound is a compound of Formula (IVa): [ka]

[0109] In some embodiments of the compound of Formula (IV), the compound is a compound of Formula (IVb): [ka]

[0110] In some embodiments of compounds of Formula (IV), (IVa) or (IVb), R 12 is -C(=O)NR 1 R 2 is.

[0111] In some embodiments of compounds of Formula (IV), (IVa) or (IVb), R 1 and R 2 is independently hydrogen, C-C alkyl, C-C haloalkyl, or C-C deuterated alkyl. In some embodiments of compounds of Formula (IV), (IVa), or (IVb), R 1 and R 2 is independently hydrogen, or C1-C6 deuterated alkyl. In some embodiments of compounds of Formula (IV), (IVa), or (IVb), R 1 is hydrogen. In some embodiments of compounds of Formula (IV), (IVa) or (IVb), R 2 is C1-C6 alkyl, or C1-C6 deuterated alkyl. In some embodiments of compounds of Formula (IV), (IVa) or (IVb), R 2 is a C1-C6 deuterated alkyl.

[0112] In some embodiments of compounds of Formula (IV), (IVa) or (IVb), R 12 -L 1 -R 13 is.

[0113] In some embodiments of compounds of Formula (IV), (IVa) or (IVb), L 1 In some embodiments of compounds of Formula (IV), (IVa) or (IVb), L 1 is —O— or —NH—.

[0114] In some embodiments of compounds of Formula (IV), (IVa) or (IVb), R 13 is C1-C6 alkyl, C1-C6 haloalkyl, or C1-C6 deuterated alkyl.

[0115] In some embodiments of compounds of Formula (IV), (IVa) or (IVb), R 5 is halogen, -CN, -OR 8 , -NR 9 R 10 , -C(=O)R 7 , -C(=O)OR 8 , -C(=O)NR 9 R 10 , -NR 8 C(=O)NR 9 R 10 , -NR 8 C(=O)R 7 , -NR 8 C(=O)OR 8 ,,C 1- C6 alkyl, C 1- C6 haloalkyl, C 1- C6 deuterated alkyl, C 2- C6 alkenyl, C 2- C alkynyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; wherein each of the alkyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl independently represents one or more of oxo, deuterium, halogen, -CN, -OR b , -NR c Rd , -C(=O)R a , -C(=O)OR b , -C(=O)NR c R d , C 1- C6 alkyl, or C 1- Optionally substituted with C6 haloalkyl.

[0116] In some embodiments of compounds of Formula (IV), (IVa), or (IVb), R 5 -OR 8 , -NR 9 R 10 , -C(=O)R 7 , -C(=O)OR 8 , -C(=O)NR 9 R 10 , -NR 8 C(=O)NR 9 R 10 , -NR 8 C(=O)R 7 , -NR 8 C(=O)OR 8 , cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; wherein each of cycloalkyl, heterocycloalkyl, aryl, and heteroaryl independently represents one or more of oxo, deuterium, halogen, —CN, —OR b , -NR c R d , -C(=O)R a , -C(=O)OR b , -C(=O)NR c R d , C1-C6 alkyl, or C1-C6 haloalkyl.

[0117] In some embodiments of compounds of Formula (IV), (IVa) or (IVb), R 5 -OR 8 , -NR 9 R 10 , -NR 8 C(=O)R 7 , or one or more of oxo, deuterium, halogen, -CN, -OR b , -NRc R d , -C(=O)R a , -C(=O)OR b , -C(=O)NR c R d , C1-C6 alkyl, or aryl optionally substituted with C1-C6 haloalkyl.

[0118] In some embodiments of compounds of Formula (IV), (IVa), or (IVb), R 5 -OR 8 , -NR 9 R 10 , -NR 8 C(=O)R 7 , cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; wherein each of the cycloalkyl, heterocycloalkyl, aryl, and heteroaryl independently represents one or more of oxo, deuterium, halogen, —CN, —OR b , -NR c R d , -C(=O)R a , -C(=O)OR b , -C(=O)NR c R d , C1-C6 alkyl, or C1-C6 haloalkyl. In some embodiments of compounds of Formula (IV), (IVa), or (IVb), R 5 is -NR 8 C(=O)R 7 In some embodiments of compounds of Formula (IV), (IVa) or (IVb), R 5 is one or more of oxo, deuterium, halogen, -CN, -OR b , -NR c R d , -C(=O)R a , -C(=O)OR b , -C(=O)NR c R d , C1-C6 alkyl, or aryl optionally substituted with C1-C6 haloalkyl.

[0119] In some embodiments of compounds of Formula (IV), (IVa) or (IVb), R 7 is C-C alkyl, C-C haloalkyl, C-C deuterated alkyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; wherein each of the alkyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl is independently optionally substituted with one or more oxo, deuterium, halogen, —CN, —OH, —OMe, —NH, —C(═O)Me, —C(═O)OH, —C(═O)OMe, C-C alkyl, or C-C haloalkyl. In some embodiments of compounds of Formula (IV), (IVa), or (IVb), R 7 is C-C alkyl, C-C haloalkyl, C-C deuterated alkyl, or cycloalkyl; wherein each of the alkyl, cycloalkyl, and heterocycloalkyl is independently optionally substituted with one or more oxo, deuterium, halogen, —CN, —OH, —OMe, —NH, —C(═O)Me, —C(═O)OH, —C(═O)OMe, C-C alkyl, or C-C haloalkyl. In some embodiments of compounds of Formula (IV), (IVa), or (IVb), R 7 is cycloalkyl optionally substituted with one or more oxo, deuterium, halogen, —CN, —OH, —OMe, —NH, —C(═O)Me, —C(═O)OH, —C(═O)OMe, C-C alkyl, or C-C haloalkyl. In some embodiments of compounds of Formula (IV), (IVa), or (IVb), R 7 is an unsubstituted cycloalkyl.

[0120] In some embodiments of compounds of Formula (IV), (IVa) or (IVb), R 8is hydrogen, C-C alkyl, C-C haloalkyl, C-C deuterated alkyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; wherein each of the alkyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl is independently optionally substituted with one or more oxo, deuterium, halogen, —CN, —OH, —OMe, —NH, —C(═O)Me, —C(═O)OH, —C(═O)OMe, C-C alkyl, or C-C haloalkyl. In some embodiments of compounds of Formula (IV), (IVa), or (IVb), R 8 is hydrogen, C-C alkyl, C-C haloalkyl, C-C deuterated alkyl, or cycloalkyl; wherein each of alkyl, cycloalkyl, and heterocycloalkyl is independently optionally substituted with one or more oxo, deuterium, halogen, —CN, —OH, —OMe, —NH, —C(═O)Me, —C(═O)OH, —C(═O)OMe, C-C alkyl, or C-C haloalkyl.

[0121] In some embodiments of compounds of Formula (IV), (IVa) or (IVb), R 9 and R 10 is independently hydrogen, C-C alkyl, C-C haloalkyl, C-C deuterated alkyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; wherein each of the alkyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl is independently optionally substituted with one or more oxo, deuterium, halogen, —CN, —OH, —OMe, —NH, —C(═O)Me, —C(═O)OH, —C(═O)OMe, C-C alkyl, or C-C haloalkyl. In some embodiments of compounds of Formula (IV), (IVa), or (IVb), R 9 and R 10are independently hydrogen, C-C alkyl, C-C haloalkyl, C-C deuterated alkyl, or cycloalkyl; wherein each of alkyl, cycloalkyl, and heterocycloalkyl is independently optionally substituted with one or more oxo, deuterium, halogen, —CN, —OH, —OMe, —NH, —C(═O)Me, —C(═O)OH, —C(═O)OMe, C-C alkyl, or C-C haloalkyl.

[0122] In some embodiments of compounds of Formula (IV), (IVa) or (IVb), Ring C is indole or benzimidazole.

[0123] In some embodiments of compounds of Formula (IV), (IVa) or (IVb), each R C are independently deuterium, halogen, -CN, -OR b , -NR c R d , -C(=O)R a , -C(=O)OR b , -C(=O)NR c R d , -OC(=O)NR c R d , C1-C6 alkyl, C1-C6 haloalkyl, or C1-C6 deuterated alkyl.

[0124] In some embodiments of compounds of Formula (IV), (IVa) or (IVb), each R C is independently deuterium, halogen, C-C alkyl, C-C haloalkyl, or C-C deuterated alkyl. In some embodiments of compounds of Formula (IV), (IVa), or (IVb), each R C is independently halogen or C1-C6 alkyl.

[0125] In some embodiments of the compound of Formula (IV), (IVa) or (IVb), m is 0. In some embodiments of the compound of Formula (IV), (IVa) or (IVb), m is 1. In some embodiments of the compound of Formula (IV), (IVa) or (IVb), m is 2. In some embodiments of the compound of Formula (IV), (IVa) or (IVb), m is 0 or 1. In some embodiments of the compound of Formula (IV), (IVa) or (IVb), m is 0 to 2. In some embodiments of the compound of Formula (IV), (IVa) or (IVb), m is 1 or 2. In some embodiments of the compound of Formula (IV), (IVa) or (IVb), m is 1 to 3.

[0126] Disclosed herein are compounds of formula (V) below, or a pharmaceutically acceptable salt, stereoisomer, or solvate thereof: [ka] During the ceremony: Ring D is cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; Each R D are independently hydrogen, deuterium, halogen, -CN, -OR b , -SR b , -S(=O)R a , -S(=O)2R a , -NO2, -NR c R d , -NHS(=O)2R a , -S(=O)2NR c R d , -C(=O)R a , -OC(=O)R a , -C(=O)OR b , -OC(=O)OR b , -C(=O)NR c R d , -OC(=O)NR c R d , -NR b C(=O)NR c R d , -NR bC(=O)R a , -NR b C(=O)OR b , C 1- C6 alkyl, C 1- C6 haloalkyl, C 1- C6 deuterated alkyl, C 1- C6 hydroxyalkyl, C 1- C6 amino alkyl, C 2- C6 alkenyl, C 2- C6 alkynyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; wherein each of the alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl independently represents one or more of oxo, deuterium, halogen, -CN, -OR b , -NR c R d , -C(=O)R a , -C(=O)OR b , -C(=O)NR c R d ,C 1- C6 alkyl, or C 1- optionally substituted with C6 haloalkyl; or two R on the same carbon D together form oxo; or two R on adjacent atoms D together form a cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; each of which may be one or more of deuterium, oxo, halogen, -CN, -OR b , -NR c R d , -C(=O)R a , -C(=O)OR b , -C(=O)NR c R d ,C 1- C6 alkyl, C 1- C6 deuterated alkyl, or C 1- optionally substituted with C6 haloalkyl; r is 0 to 4; each Y is independently C or N; R 1 and R2 are independently hydrogen, C 1- C6 alkyl, C 1- C6 haloalkyl, C 1- C6 deuterated alkyl, C 1- C6 hydroxyalkyl, C 1- C6 amino alkyl, C 2- C6 alkenyl, or C 2- C6 alkynyl; R 3 is hydrogen, C 1- C6 alkyl, C 1- C6 haloalkyl, or C 1- C6 deuterated alkyl; R 4 is hydrogen, deuterium, halogen, -CN, -OR b , -SR b , -S(=O)R a , -S(=O)2R a , -NO2, -NR c R d , -NHS(=O)2R a , -S(=O)2NR c R d , -C(=O)R a , -OC(=O)R a , -C(=O)OR b , -OC(=O)OR b , -C(=O)NR c R d , -OC(=O)NR c R d , -NR b C(=O)NR c R d , -NR b C(=O)R a , -NR b C(=O)OR b , C 1- C6 alkyl, C 1- C6 haloalkyl, C 1- C6 deuterated alkyl, C 1- C6 hydroxyalkyl, C 1- C6 amino alkyl, C 2- C6 alkenyl, or C 2- C6 alkynyl; or R 3 and R 4 together form an optionally substituted ring; L is a bond or -C(=O)-; Ring A is a cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; each of which is selected from the group consisting of one or more R A optionally replaced by; Each R A are independently deuterium, halogen, -CN, -OR b , -SR b , -S(=O)R a , -S(=O)2R a , -NO2, -NR c R d , -NHS(=O)2R a , -S(=O)2NR c R d , -C(=O)R a , -OC(=O)R a , -C(=O)OR b , -OC(=O)OR b , -C(=O)NR c R d , -OC(=O)NR c R d , -NR b C(=O)NR c R d , -NR b C(=O)R a , -NR b C(=O)OR b , C 1- C6 alkyl, C 1- C6 haloalkyl, C 1- C6 deuterated alkyl, C 1- C6 hydroxyalkyl, C 1- C6 amino alkyl, C 2- C6 alkenyl, C 2- C6 alkynyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; wherein each of the alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl independently represents one or more of oxo, deuterium, halogen, -CN, -ORb , -NR c R d , -C(=O)R a , -C(=O)OR b , -C(=O)NR c R d , C 1- C6 alkyl, or C 1- optionally substituted with C6 haloalkyl; or two R on the same carbon A together form oxo; Each X is independently -CR x -or-N-; Each R X are independently hydrogen, deuterium, halogen, -CN, -OR b , -SR b , -S(=O)R a , -S(=O)2R a , -NO2, -NR c R d , -NHS(=O)2R a , -S(=O)2NR c R d , -C(=O)R a , -OC(=O)R a , -C(=O)OR b , -OC(=O)OR b , -C(=O)NR c R d , -OC(=O)NR c R d , -NR b C(=O)NR c R d , -NR b C(=O)R a , -NR b C(=O)OR b , C 1- C6 alkyl, C 1- C6 haloalkyl, C 1- C6 deuterated alkyl, C 1- C6 hydroxyalkyl, C 1- C6 amino alkyl, C 2- C6 alkenyl, or C 2- C6 alkynyl; Each Ra independently, C 1- C6 alkyl, C 1- C6 haloalkyl, C 1- C6 deuterated alkyl, C 1- C6 hydroxyalkyl, C 1- C6 amino alkyl, C 2- C6 alkenyl, C 2- C alkynyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; wherein each of the alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl independently represents one or more of oxo, deuterium, halogen, —CN, —OH, —OMe, —NH, —C(═O)Me, —C(═O)OH, —C(═O)OMe, C 1- C6 alkyl, or C 1- optionally substituted with C6 haloalkyl; Each R b are independently hydrogen, C 1- C6 alkyl, C 1- C6 haloalkyl, C 1- C6 deuterated alkyl, C 1- C6 hydroxyalkyl, C 1- C6 amino alkyl, C 2- C6 alkenyl, C 2- C alkynyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; wherein each of the alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl independently represents one or more of oxo, deuterium, halogen, —CN, —OH, —OMe, —NH, —C(═O)Me, —C(═O)OH, —C(═O)OMe, C 1- C6 alkyl, or C 1- optionally substituted with C6 haloalkyl; Each R c and R d are independently hydrogen, C 1- C6 alkyl, C 1- C6 haloalkyl, C 1- C6 deuterated alkyl, C 1- C6 hydroxyalkyl, C1- C6 amino alkyl, C 2- C6 alkenyl, C 2- C alkynyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; wherein each of the alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl independently represents one or more of oxo, deuterium, halogen, —CN, —OH, —OMe, —NH, —C(═O)Me, —C(═O)OH, —C(═O)OMe, C 1- C6 alkyl, or C 1- optionally substituted with C6 haloalkyl; or R c and R d together with the nitrogen atom to which they are attached, one or more of oxo, deuterium, halogen, -CN, -OH, -OMe, -NH2, -C(=O)Me, -C(=O)OH, -C(=O)OMe, C 1- C6 alkyl, or C 1- forming a heterocycloalkyl optionally substituted with C6 haloalkyl;

[0127] In some embodiments of the compound of Formula (V), L is a bond. In some embodiments of the compound of Formula (V), L is -C(=O)-.

[0128] In some embodiments of compounds of Formula (V), ring A is heterocycloalkyl or heteroaryl; each of which may contain one or more R A In some embodiments of compounds of Formula (V), ring A is a 5-membered heterocycloalkyl or a 5-membered heteroaryl; each optionally substituted with one or more R A In some embodiments of compounds of Formula (V), ring A is optionally substituted with one or more R A is heteroaryl optionally substituted with

[0129] In some embodiments of compounds of Formula (V), each R A are independently deuterium, halogen, -CN, -OR b , -NR c Rd , -C(=O)R a , -C(=O)OR b , -C(=O)NR c R d , -OC(=O)NR c R d , C 1- C6 alkyl, C 1- C6 haloalkyl, or C 1- In some embodiments of the compound of Formula (V), each R A is independently deuterium, halogen, C-C alkyl, C-C haloalkyl, or C-C deuterated alkyl. In some embodiments of compounds of Formula (V), each R A is independently halogen or C1-C6 alkyl. In some embodiments of compounds of Formula (V), each R A are independently C1-C6 alkyl.

[0130] In some embodiments of compounds of Formula (V), R 4 is hydrogen, deuterium, halogen, -CN, -OR b , -NR c R d , -C(=O)R a , -C(=O)OR b , -C(=O)NR c R d , -OC(=O)NR c R d , C 1- C6 alkyl, C 1- C6 haloalkyl, or C 1- In some embodiments of the compound of formula (V), R 4 is hydrogen or -OR b In some embodiments of the compound of Formula (V), R 4 -OR b In some embodiments of the compound of Formula (V), R 4 is hydrogen.

[0131] In some embodiments of the compound of Formula (V), each X is -N-. In some embodiments of the compound of Formula (V), each X is -CH-. In some embodiments of the compound of Formula (V), one X is -N- and the other X is -CH-.

[0132] In some embodiments of the compound of Formula (V), the compound is a compound of Formula (Va): [ka]

[0133] In some embodiments of the compound of Formula (V), the compound is a compound of Formula (Vb): [ka]

[0134] In some embodiments of compounds of Formula (V), (Va) or (Vb), R 3 is hydrogen or C1-C6 alkyl. In some embodiments of compounds of Formula (V), (Va) or (Vb), R 3 is hydrogen.

[0135] In some embodiments of compounds of Formula (V), (Va) or (Vb), R 1 and R 2 is independently hydrogen, C-C alkyl, C-C haloalkyl, or C-C deuterated alkyl. In some embodiments of compounds of Formula (V), (Va), or (Vb), R 1 and R 2 is independently hydrogen, or C1-C6 deuterated alkyl. In some embodiments of compounds of Formula (V), (Va), or (Vb), R 1 is hydrogen. In some embodiments of compounds of Formula (V), (Va) or (Vb), R 2 is C1-C6 alkyl, or C1-C6 deuterated alkyl. In some embodiments of compounds of Formula (V), (Va), or (Vb), R 2 is a C1-C6 deuterated alkyl.

[0136] In some embodiments of compounds of Formula (V), (Va), or (Vb), Ring D is heterocycloalkyl or heteroaryl.

[0137] In some embodiments of compounds of Formula (V), (Va) or (Vb), [ka] and r' is 0 to 3.

[0138] In some embodiments of compounds of Formula (V), (Va) or (Vb), each R D are independently hydrogen, deuterium, halogen, -CN, -OR b , -NR c R d , -C(=O)R a , -C(=O)OR b , -C(=O)NR c R d , C 1- C6 alkyl, C 1- C6 haloalkyl, C 1- In some embodiments of compounds of Formula (V), (Va), or (Vb), each R D is independently hydrogen, deuterium, halogen, C-C alkyl, C-C haloalkyl, C-C deuterated alkyl, or cycloalkyl. In some embodiments of compounds of Formula (V), (Va), or (Vb), each R D is independently hydrogen or cycloalkyl.

[0139] In some embodiments of a compound of Formula (V), (Va) or (Vb), r is 0. In some embodiments of a compound of Formula (V), (Va) or (Vb), r is 1. In some embodiments of a compound of Formula (V), (Va) or (Vb), r is 2. In some embodiments of a compound of Formula (V), (Va) or (Vb), r is 0 to 2. In some embodiments of a compound of Formula (V), (Va) or (Vb), r is 0 or 1. In some embodiments of a compound of Formula (V), (Va) or (Vb), r is 1 or 2. In some embodiments of a compound of Formula (V), (Va) or (Vb), r is 1 to 3.

[0140] In some embodiments of the compound of Formula (V), (Va) or (Vb), r' is 0. In some embodiments of the compound of Formula (V), (Va) or (Vb), r' is 1. In some embodiments of the compound of Formula (V), (Va) or (Vb), r' is 2. In some embodiments of the compound of Formula (V), (Va) or (Vb), r' is 0 to 2. In some embodiments of the compound of Formula (V), (Va) or (Vb), r' is 0 or 1. In some embodiments of the compound of Formula (V), (Va) or (Vb), r' is 1 or 2. In some embodiments of the compound of Formula (V), (Va) or (Vb), r' is 1 to 3.

[0141] Disclosed herein is a compound of formula (VI) below, or a pharmaceutically acceptable salt, stereoisomer, or solvate thereof: [ka] During the ceremony: Ring E is a cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; each of which is selected from the group consisting of one or more R E optionally replaced by; Each R E are independently deuterium, halogen, -CN, -OR b , -SR b , -S(=O)R a , -S(=O)2R a, -NO2, -NR c R d , -NHS(=O)2R a , -S(=O)2NR c R d , -C(=O)R a , -OC(=O)R a , -C(=O)OR b , -OC(=O)OR b , -C(=O)NR c R d , -OC(=O)NR c R d , -NR b C(=O)NR c R d , -NR b C(=O)R a , -NR b C(=O)OR b , C 1- C6 alkyl, C 1- C6 haloalkyl, C 1- C6 deuterated alkyl, C 1- C6 hydroxyalkyl, C 1- C6 amino alkyl, C 2- C6 alkenyl, C 2- C6 alkynyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; wherein each of the alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl independently represents one or more of oxo, deuterium, halogen, -CN, -OR b , -NR c R d , -C(=O)R a , -C(=O)OR b , -C(=O)NR c R d , C 1- C6 alkyl, or C 1- optionally substituted with C6 haloalkyl; or two R on the same carbon E together form oxo; L 2 is a bond, -O-, or [ka] and; R 1 and R 2 are independently hydrogen, C 1- C6 alkyl, C 1- C6 haloalkyl, C 1- C6 deuterated alkyl, C 1- C6 hydroxyalkyl, C 1- C6 amino alkyl, C 2- C6 alkenyl, or C 2- C6 alkynyl; R 3 is hydrogen, C 1- C6 alkyl, C 1- C6 haloalkyl, or C 1- C6 deuterated alkyl; R 4 is hydrogen, deuterium, halogen, -CN, -OR b , -SR b , -S(=O)R a , -S(=O)2R a , -NO2, -NR c R d , -NHS(=O)2R a , -S(=O)2NR c R d , -C(=O)R a , -OC(=O)R a , -C(=O)OR b , -OC(=O)OR b , -C(=O)NR c R d , -OC(=O)NR c R d , -NR b C(=O)NR c R d , -NR b C(=O)R a , -NR b C(=O)OR b , C 1- C6 alkyl, C 1- C6 haloalkyl, C 1- C6 deuterated alkyl, C 1- C6 hydroxyalkyl, C 1-C6 amino alkyl, C 2- C6 alkenyl, or C 2- C6 alkynyl; or R 3 and R 4 together form an optionally substituted ring; L is a bond or -C(=O)-; Ring A is a cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; each of which is selected from the group consisting of one or more R A optionally replaced by; Each R A are independently deuterium, halogen, -CN, -OR b , -SR b , -S(=O)R a , -S(=O)2R a , -NO2, -NR c R d , -NHS(=O)2R a , -S(=O)2NR c R d , -C(=O)R a , -OC(=O)R a , -C(=O)OR b , -OC(=O)OR b , -C(=O)NR c R d , -OC(=O)NR c R d , -NR b C(=O)NR c R d , -NR b C(=O)R a , -NR b C(=O)OR b , C 1- C6 alkyl, C 1- C6 haloalkyl, C 1- C6 deuterated alkyl, C 1- C6 hydroxyalkyl, C 1- C6 amino alkyl, C 2- C6 alkenyl, C 2-C6 alkynyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; wherein each of the alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl independently represents one or more of oxo, deuterium, halogen, -CN, -OR b , -NR c R d , -C(=O)R a , -C(=O)OR b , -C(=O)NR c R d , C 1- C6 alkyl, or C 1- optionally substituted with C6 haloalkyl; or two R on the same carbon A together form oxo; X is -CR x -or-N-; R X is hydrogen, deuterium, halogen, -CN, -OR b , -SR b , -S(=O)R a , -S(=O)2R a , -NO2, -NR c R d , -NHS(=O)2R a , -S(=O)2NR c R d , -C(=O)R a , -OC(=O)R a , -C(=O)OR b , -OC(=O)OR b , -C(=O)NR c R d , -OC(=O)NR c R d , -NR b C(=O)NR c R d , -NR b C(=O)R a , -NR b C(=O)OR b , C 1- C6 alkyl, C 1- C6 haloalkyl, C 1-C6 deuterated alkyl, C 1- C6 hydroxyalkyl, C 1- C6 amino alkyl, C 2- C6 alkenyl, or C 2- C6 alkynyl; Each R a independently, C 1- C6 alkyl, C 1- C6 haloalkyl, C 1- C6 deuterated alkyl, C 1- C6 hydroxyalkyl, C 1- C6 amino alkyl, C 2- C6 alkenyl, C 2- C alkynyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; wherein each of the alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl independently represents one or more of oxo, deuterium, halogen, —CN, —OH, —OMe, —NH, —C(═O)Me, —C(═O)OH, —C(═O)OMe, C 1- C6 alkyl, or C 1- optionally substituted with C6 haloalkyl; Each R b are independently hydrogen, C 1- C6 alkyl, C 1- C6 haloalkyl, C 1- C6 deuterated alkyl, C 1- C6 hydroxyalkyl, C 1- C6 amino alkyl, C 2- C6 alkenyl, C 2- C alkynyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; wherein each of the alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl independently represents one or more of oxo, deuterium, halogen, —CN, —OH, —OMe, —NH, —C(═O)Me, —C(═O)OH, —C(═O)OMe, C 1- C6 alkyl, or C 1- optionally substituted with C6 haloalkyl; Each R cand R d are independently hydrogen, C 1- C6 alkyl, C 1- C6 haloalkyl, C 1- C6 deuterated alkyl, C 1- C6 hydroxyalkyl, C 1- C6 amino alkyl, C 2- C6 alkenyl, C 2- C alkynyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; wherein each of the alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl independently represents one or more of oxo, deuterium, halogen, —CN, —OH, —OMe, —NH, —C(═O)Me, —C(═O)OH, —C(═O)OMe, C 1- C6 alkyl, or C 1- optionally substituted with C6 haloalkyl; or R c and R d together with the nitrogen atom to which they are attached, one or more of oxo, deuterium, halogen, -CN, -OH, -OMe, -NH2, -C(=O)Me, -C(=O)OH, -C(=O)OMe, C 1- C6 alkyl, or C 1- forming a heterocycloalkyl optionally substituted with C6 haloalkyl;

[0142] In some embodiments of the compound of Formula (VI), L is a bond. In some embodiments of the compound of Formula (VI), L is -C(=O)-.

[0143] In some embodiments of compounds of Formula (VI), ring A is heterocycloalkyl or heteroaryl; each of which contains one or more R A In some embodiments of compounds of Formula (VI), ring A is a 5-membered heterocycloalkyl or a 5-membered heteroaryl; each optionally substituted with one or more R A In some embodiments of the compound of Formula (VI), ring A is optionally substituted with one or more R A is heteroaryl optionally substituted with

[0144] In some embodiments of the compound of Formula (VI), each R A are independently deuterium, halogen, -CN, -OR b , -NR c R d , -C(=O)R a , -C(=O)OR b , -C(=O)NR c R d , -OC(=O)NR c R d , C 1- C6 alkyl, C 1- C6 haloalkyl, or C 1- In some embodiments of the compound of Formula (VI), each R A is independently deuterium, halogen, C-C alkyl, C-C haloalkyl, or C-C deuterated alkyl. In some embodiments of compounds of Formula (VI), each R A is independently halogen or C1-C6 alkyl. In some embodiments of compounds of Formula (VI), each R A are independently C1-C6 alkyl.

[0145] In some embodiments of the compound of Formula (VI), R 4 is hydrogen, deuterium, halogen, -CN, -OR b , -NR c R d , -C(=O)R a , -C(=O)OR b , -C(=O)NR c R d , -OC(=O)NR c R d , C 1- C6 alkyl, C 1- C6 haloalkyl, or C 1- In some embodiments of the compound of formula (VI), R 4 is hydrogen or -OR b In some embodiments of the compound of Formula (VI), R 4 -OR bIn some embodiments of the compound of Formula (VI), R 4 is hydrogen.

[0146] In some embodiments of the compound of Formula (VI), X is -CH-. In some embodiments of the compound of Formula (VI), X is -N-.

[0147] In some embodiments of the compound of Formula (VI), the compound is a compound of Formula (VIa): [ka]

[0148] In some embodiments of the compound of Formula (VI), the compound is a compound of Formula (VIb): [ka]

[0149] In some embodiments of compounds of Formula (VI), (VIa) or (VIb), R 3 is hydrogen or C1-C6 alkyl. In some embodiments of compounds of Formula (VI), (VIa) or (VIb), R 3 is hydrogen.

[0150] In some embodiments of compounds of Formula (VI), (VIa) or (VIb), R 1 and R 2 is independently hydrogen, C-C alkyl, C-C haloalkyl, or C-C deuterated alkyl. In some embodiments of compounds of Formula (VI), (VIa), or (VIb), R 1 and R 2 is independently hydrogen, or C1-C6 deuterated alkyl. In some embodiments of compounds of Formula (VI), (VIa), or (VIb), R 1 is hydrogen. In some embodiments of compounds of Formula (VI), (VIa) or (VIb), R 2is C1-C6 alkyl, or C1-C6 deuterated alkyl. In some embodiments of compounds of Formula (VI), (VIa), or (VIb), R 2 is a C1-C6 deuterated alkyl.

[0151] In some embodiments of compounds of Formula (VI), (VIa) or (VIb), L 2 is a bond.

[0152] In some embodiments of compounds of Formula (VI), (VIa), or (VIb), ring E is cycloalkyl, heterocycloalkyl, or aryl; each of which contains one or more R E is optionally replaced by

[0153] In some embodiments of compounds of Formula (VI), (VIa) or (VIb), ring E is selected from the group consisting of one or more R E is aryl optionally substituted with

[0154] In some embodiments of compounds of Formula (VI), (VIa) or (VIb), each R E are independently deuterium, halogen, -CN, -OR b , -NR c R d , -C(=O)R a , -C(=O)OR b , -C(=O)NR c R d , C 1- C6 alkyl, C 1- C6 haloalkyl, or C 1- It is a C6 deuterated alkyl.

[0155] In some embodiments of compounds of Formula (VI), (VIa) or (VIb), each R E are independently deuterium, halogen, C1-C6 alkyl, C1-C6 haloalkyl, or C1-C6 deuterated alkyl.

[0156] In some embodiments of compounds of Formula (VI), (VIa) or (VIb), each R Eare independently halogen.

[0157] Disclosed herein is a compound of formula (VII) below, or a pharmaceutically acceptable salt, stereoisomer, or solvate thereof: [ka] During the ceremony: R 14 is hydrogen, -S(=O)R a , -S(=O)2R a , -S(=O)2NR c R d , -C(=O)R a , -C(=O)OR b , -C(=O)NR c R d , C 1- C6 alkyl, C 1- C6 haloalkyl, C 1- C6 deuterated alkyl, C 1- C6 hydroxyalkyl, C 1- C6 amino alkyl, C 2- C6 alkenyl, C 2- C6 alkynyl, C 1- C6 alkyl (cycloalkyl), C 1- C6 alkyl (heterocycloalkyl), C 1- C6 alkyl (aryl), C1-C6 alkyl (heteroaryl), cycloalkyl, or heterocycloalkyl; R 3 is hydrogen, C 1- C6 alkyl, C 1- C6 haloalkyl, or C 1- C6 deuterated alkyl; R 4 is hydrogen, deuterium, halogen, -CN, -OR b , -SR b , -S(=O)R a , -S(=O)2R a , -NO2, -NR c R d , -NHS(=O)2R a , -S(=O)2NR c Rd , -C(=O)R a , -OC(=O)R a , -C(=O)OR b , -OC(=O)OR b , -C(=O)NR c R d , -OC(=O)NR c R d , -NR b C(=O)NR c R d , -NR b C(=O)R a , -NR b C(=O)OR b , C 1- C6 alkyl, C 1- C6 haloalkyl, C 1- C6 deuterated alkyl, C 1- C6 hydroxyalkyl, C 1- C6 amino alkyl, C 2- C6 alkenyl, or C 2- C6 alkynyl; or R 3 and R 4 together form an optionally substituted ring; L is a bond or -C(=O)-; Ring A is a cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; each of which is selected from the group consisting of one or more R A optionally replaced by; Each R A are independently deuterium, halogen, -CN, -OR b , -SR b , -S(=O)R a , -S(=O)2R a , -NO2, -NR c R d , -NHS(=O)2R a , -S(=O)2NR c R d , -C(=O)R a , -OC(=O)R a , -C(=O)OR b , -OC(=O)OR b , -C(=O)NRc R d , -OC(=O)NR c R d , -NR b C(=O)NR c R d , -NR b C(=O)R a , -NR b C(=O)OR b , C 1- C6 alkyl, C 1- C6 haloalkyl, C 1- C6 deuterated alkyl, C 1- C6 hydroxyalkyl, C 1- C6 amino alkyl, C 2- C6 alkenyl, C 2- C6 alkynyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; wherein each of the alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl independently represents one or more of oxo, deuterium, halogen, -CN, -OR b , -NR c R d , -C(=O)R a , -C(=O)OR b , -C(=O)NR c R d , C 1- C6 alkyl, or C 1- optionally substituted with C6 haloalkyl; or two R on the same carbon A together form oxo; X is -CR x -or-N-; R X is hydrogen, deuterium, halogen, -CN, -OR b , -SR b , -S(=O)R a , -S(=O)2R a , -NO2, -NR c R d , -NHS(=O)2R a , -S(=O)2NR c R d , -C(=O)Ra , -OC(=O)R a , -C(=O)OR b , -OC(=O)OR b , -C(=O)NR c R d , -OC(=O)NR c R d , -NR b C(=O)NR c R d , -NR b C(=O)R a , -NR b C(=O)OR b , C 1- C6 alkyl, C 1- C6 haloalkyl, C 1- C6 deuterated alkyl, C 1- C6 hydroxyalkyl, C 1- C6 amino alkyl, C 2- C6 alkenyl, or C 2- C6 alkynyl; Each R a independently, C 1- C6 alkyl, C 1- C6 haloalkyl, C 1- C6 deuterated alkyl, C 1- C6 hydroxyalkyl, C 1- C6 amino alkyl, C 2- C6 alkenyl, C 2- C alkynyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; wherein each of the alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl independently represents one or more of oxo, deuterium, halogen, —CN, —OH, —OMe, —NH, —C(═O)Me, —C(═O)OH, —C(═O)OMe, C 1- C6 alkyl, or C 1- optionally substituted with C6 haloalkyl; R 5 is halogen, -CN, -OR 8 , -SR 8 , -S(=O)R 7 , -S(=O)2R 7, -NO2, -NR 9 R 10 , -NHS(=O)2R 7 , -S(=O)2NR 9 R 10 , -C(=O)R 7 , -OC(=O)R 7 , -C(=O)OR 8 , -OC(=O)OR 8 , -C(=O)NR 9 R 10 , -OC(=O)NR 9 R 10 , -NR 8 C(=O)NR 9 R 10 , -NR 8 C(=O)R 7 , -NR 8 C(=O)OR 8 , C 1- C6 alkyl, C 1- C6 haloalkyl, C 1- C6 deuterated alkyl, C 1- C6 hydroxyalkyl, C 1- C6 amino alkyl, C 2- C6 alkenyl, C 2- C6 alkynyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; wherein each of the alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl independently represents one or more of oxo, deuterium, halogen, -CN, -OR b , -NR c R d , -C(=O)R a , -C(=O)OR b , -C(=O)NR c R d , C 1- C6 alkyl, or C 1- optionally substituted with C6 haloalkyl; or R X and R 5 together with one or more R D forming a ring D optionally substituted with; Ring D is cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; Each R D are independently hydrogen, deuterium, halogen, -CN, -OR b , -SR b , -S(=O)R a , -S(=O)2R a , -NO2, -NR c R d , -NHS(=O)2R a , -S(=O)2NR c R d , -C(=O)R a , -OC(=O)R a , -C(=O)OR b , -OC(=O)OR b , -C(=O)NR c R d , -OC(=O)NR c R d , -NR b C(=O)NR c R d , -NR b C(=O)R a , -NR b C(=O)OR b , C 1- C6 alkyl, C 1- C6 haloalkyl, C 1- C6 deuterated alkyl, C 1- C6 hydroxyalkyl, C 1- C6 amino alkyl, C 2- C6 alkenyl, C 2- C6 alkynyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; wherein each of the alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl independently represents one or more of oxo, deuterium, halogen, -CN, -OR b , -NR c R d , -C(=O)R a , -C(=O)OR b , -C(=O)NR c R d , C1- C6 alkyl, or C 1- optionally substituted with C6 haloalkyl; or two R on the same carbon D together form oxo; R 7 is C 1- C6 alkyl, C 1- C6 haloalkyl, C 1- C6 deuterated alkyl, C 1- C6 hydroxyalkyl, C 1- C6 amino alkyl, C 2- C6 alkenyl, C 2- C alkynyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; wherein each of the alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl independently represents one or more of oxo, deuterium, halogen, —CN, —OH, —OMe, —NH, —C(═O)Me, —C(═O)OH, —C(═O)OMe, C 1- C6 alkyl, or C 1- optionally substituted with C6 haloalkyl; Each R 8 are independently hydrogen, C 1- C6 alkyl, C 1- C6 haloalkyl, C 1- C6 deuterated alkyl, C 1- C6 hydroxyalkyl, C 1- C6 amino alkyl, C 2- C6 alkenyl, C 2- C alkynyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; wherein each of the alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl independently represents one or more of oxo, deuterium, halogen, —CN, —OH, —OMe, —NH, —C(═O)Me, —C(═O)OH, —C(═O)OMe, C 1- C6 alkyl, or C 1- optionally substituted with C6 haloalkyl; R 9 and R 10are independently hydrogen, C 1- C6 alkyl, C 1- C6 haloalkyl, C 1- C6 deuterated alkyl, C 1- C6 hydroxyalkyl, C 1- C6 amino alkyl, C 2- C6 alkenyl, C 2- C alkynyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; wherein each of the alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl independently represents one or more of oxo, deuterium, halogen, —CN, —OH, —OMe, —NH, —C(═O)Me, —C(═O)OH, —C(═O)OMe, C 1- C6 alkyl, or C 1- optionally substituted with C6 haloalkyl; or R 9 and R 10 together with the nitrogen atom to which they are attached, one or more of oxo, deuterium, halogen, -CN, -OH, -OMe, -NH2, -C(=O)Me, -C(=O)OH, -C(=O)OMe, C 1- C6 alkyl, or C 1- forming a heterocycloalkyl optionally substituted with C6 haloalkyl; Each R b are independently hydrogen, C 1- C6 alkyl, C 1- C6 haloalkyl, C 1- C6 deuterated alkyl, C 1- C6 hydroxyalkyl, C 1- C6 amino alkyl, C 2- C6 alkenyl, C 2- C alkynyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; wherein each of the alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl independently represents one or more of oxo, deuterium, halogen, —CN, —OH, —OMe, —NH, —C(═O)Me, —C(═O)OH, —C(═O)OMe, C 1-C6 alkyl, or C 1- optionally substituted with C6 haloalkyl; Each R c and R d are independently hydrogen, C 1- C6 alkyl, C 1- C6 haloalkyl, C 1- C6 deuterated alkyl, C 1- C6 hydroxyalkyl, C 1- C6 amino alkyl, C 2- C6 alkenyl, C 2- C alkynyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; wherein each of the alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl independently represents one or more of oxo, deuterium, halogen, —CN, —OH, —OMe, —NH, —C(═O)Me, —C(═O)OH, —C(═O)OMe, C 1- C6 alkyl, or C 1- optionally substituted with C6 haloalkyl; or R c and R d together with the nitrogen atom to which they are attached, one or more of oxo, deuterium, halogen, -CN, -OH, -OMe, -NH2, -C(=O)Me, -C(=O)OH, -C(=O)OMe, C 1- C6 alkyl, or C 1- forming a heterocycloalkyl optionally substituted with C6 haloalkyl;

[0158] In some embodiments of the compound of Formula (VII), L is a bond. In some embodiments of the compound of Formula (VII), L is -C(=O)-.

[0159] In some embodiments of compounds of Formula (VII), ring A is heterocycloalkyl or heteroaryl; each of which contains one or more R A In some embodiments of compounds of Formula (VII), ring A is a 5-membered heterocycloalkyl or a 5-membered heteroaryl; each optionally substituted with one or more R AIn some embodiments of the compound of Formula (VII), ring A is optionally substituted with one or more R A is heteroaryl optionally substituted with

[0160] In some embodiments of the compound of Formula (VII), each R A are independently deuterium, halogen, -CN, -OR b , -NR c R d , -C(=O)R a , -C(=O)OR b , -C(=O)NR c R d , -OC(=O)NR c R d , C 1- C6 alkyl, C 1- C6 haloalkyl, or C 1- In some embodiments of the compound of Formula (VII), each R A is independently deuterium, halogen, C-C alkyl, C-C haloalkyl, or C-C deuterated alkyl. In some embodiments of compounds of Formula (VII), each R A is independently halogen or C1-C6 alkyl. In some embodiments of compounds of Formula (VII), each R A are independently C1-C6 alkyl.

[0161] In some embodiments of the compound of Formula (VII), R 4 is hydrogen, deuterium, halogen, -CN, -OR b , -NR c R d , -C(=O)R a , -C(=O)OR b , -C(=O)NR c R d , -OC(=O)NR c R d , C 1- C6 alkyl, C 1- C6 haloalkyl, or C 1- In some embodiments of the compound of formula (VII), R 4is hydrogen or -OR b In some embodiments of the compound of Formula (VII), R 4 -OR b In some embodiments of the compound of Formula (VII), R 4 is hydrogen.

[0162] In some embodiments of the compound of Formula (VII), X is -CH-. In some embodiments of the compound of Formula (VII), X is -N-.

[0163] In some embodiments of the compound of Formula (VII), the compound is a compound of Formula (VIIa): [ka]

[0164] In some embodiments of the compound of Formula (VII), the compound is a compound of Formula (VIIb): [ka]

[0165] In some embodiments of compounds of Formula (VII), (VIIa) or (VIIb), R 3 is hydrogen or C1-C6 alkyl. In some embodiments of compounds of Formula (VII), (VIIa) or (VIIb), R 3 is hydrogen.

[0166] In some embodiments of compounds of Formula (VII), (VIIa) or (VIIb), R 5 is halogen, -CN, -OR 8 , -NR 9 R 10 , -C(=O)R 7 , -C(=O)OR 8 , -C(=O)NR 9 R 10 , -NR 8 C(=O)NR 9 R 10 , -NR 8C(=O)R 7 , -NR 8 C(=O)OR 8 , C 1- C6 alkyl, C 1- C6 haloalkyl, C 1- C6 deuterated alkyl, C 2- C6 alkenyl, C 2- C alkynyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; wherein each of the alkyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl independently represents one or more of oxo, deuterium, halogen, -CN, -OR b , -NR c R d , -C(=O)R a , -C(=O)OR b , -C(=O)NR c R d , C 1- C6 alkyl, or C 1- Optionally substituted with C6 haloalkyl.

[0167] In some embodiments of compounds of Formula (VII), (VIIa), or (VIIb), R 5 -OR 8 , -NR 9 R 10 , -C(=O)R 7 , -C(=O)OR 8 , -C(=O)NR 9 R 10 , -NR 8 C(=O)NR 9 R 10 , -NR 8 C(=O)R 7 , -NR 8 C(=O)OR 8 , cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; wherein each of the cycloalkyl, heterocycloalkyl, aryl, and heteroaryl independently represents one or more of oxo, deuterium, halogen, —CN, —OR b , -NR c R d , -C(=O)Ra , -C(=O)OR b , -C(=O)NR c R d , C1-C6 alkyl, or C1-C6 haloalkyl.

[0168] In some embodiments of compounds of Formula (VII), (VIIa) or (VIIb), R 5 -OR 8 , -NR 9 R 10 , -NR 8 C(=O)R 7 , or one or more of oxo, deuterium, halogen, -CN, -OR b , -NR c R d , -C(=O)R a , -C(=O)OR b , -C(=O)NR c R d , C1-C6 alkyl, or C1-C6 haloalkyl.

[0169] In some embodiments of compounds of Formula (VII), (VIIa), or (VIIb), R 5 -OR 8 , -NR 9 R 10 , -NR 8 C(=O)R 7 , cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; wherein each of the cycloalkyl, heterocycloalkyl, aryl, and heteroaryl independently represents one or more of oxo, deuterium, halogen, —CN, —OR b , -NR c R d , -C(=O)R a , -C(=O)OR b , -C(=O)NR c R d , C1-C6 alkyl, or C1-C6 haloalkyl. In some embodiments of compounds of Formula (VII), (VIIa), or (VIIb), R 5 is -NR8 C(=O)R 7 In some embodiments of compounds of Formula (VII), (VIIa) or (VIIb), R 5 is one or more of oxo, deuterium, halogen, -CN, -OR b , -NR c R d , -C(=O)R a , -C(=O)OR b , -C(=O)NR c R d , C1-C6 alkyl, or C1-C6 haloalkyl.

[0170] In some embodiments of compounds of Formula (VII), (VIIa) or (VIIb), R 7 is C-C alkyl, C-C haloalkyl, C-C deuterated alkyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; wherein each of the alkyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl is independently optionally substituted with one or more oxo, deuterium, halogen, —CN, —OH, —OMe, —NH, —C(═O)Me, —C(═O)OH, —C(═O)OMe, C-C alkyl, or C-C haloalkyl. In some embodiments of compounds of Formula (VII), (VIIa), or (VIIb), R 7 is C-C alkyl, C-C haloalkyl, C-C deuterated alkyl, or cycloalkyl; wherein each of the alkyl, cycloalkyl, and heterocycloalkyl is independently optionally substituted with one or more oxo, deuterium, halogen, —CN, —OH, —OMe, —NH, —C(═O)Me, —C(═O)OH, —C(═O)OMe, C-C alkyl, or C-C haloalkyl. In some embodiments of compounds of Formula (VII), (VIIa), or (VIIb), R 7is cycloalkyl optionally substituted with one or more oxo, deuterium, halogen, —CN, —OH, —OMe, —NH, —C(═O)Me, —C(═O)OH, —C(═O)OMe, C-C alkyl, or C-C haloalkyl. In some embodiments of compounds of Formula (VII), (VIIa), or (VIIb), R 7 is an unsubstituted cycloalkyl.

[0171] In some embodiments of compounds of Formula (VII), (VIIa) or (VIIb), R 8 is hydrogen, C-C alkyl, C-C haloalkyl, C-C deuterated alkyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; wherein each of the alkyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl is independently optionally substituted with one or more oxo, deuterium, halogen, —CN, —OH, —OMe, —NH, —C(═O)Me, —C(═O)OH, —C(═O)OMe, C-C alkyl, or C-C haloalkyl. In some embodiments of compounds of Formula (VII), (VIIa), or (VIIb), R 8 is hydrogen, C-C alkyl, C-C haloalkyl, C-C deuterated alkyl, or cycloalkyl; wherein each of alkyl, cycloalkyl, and heterocycloalkyl is independently optionally substituted with one or more oxo, deuterium, halogen, —CN, —OH, —OMe, —NH, —C(═O)Me, —C(═O)OH, —C(═O)OMe, C-C alkyl, or C-C haloalkyl.

[0172] In some embodiments of compounds of Formula (VII), (VIIa) or (VIIb), R 9 and R 10is independently hydrogen, C-C alkyl, C-C haloalkyl, C-C deuterated alkyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; wherein each of the alkyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl is independently optionally substituted with one or more oxo, deuterium, halogen, —CN, —OH, —OMe, —NH, —C(═O)Me, —C(═O)OH, —C(═O)OMe, C-C alkyl, or C-C haloalkyl. In some embodiments of compounds of Formula (VII), (VIIa), or (VIIb), R 9 and R 10 are independently hydrogen, C-C alkyl, C-C haloalkyl, C-C deuterated alkyl, or cycloalkyl; wherein each of alkyl, cycloalkyl, and heterocycloalkyl is independently optionally substituted with one or more oxo, deuterium, halogen, —CN, —OH, —OMe, —NH, —C(═O)Me, —C(═O)OH, —C(═O)OMe, C-C alkyl, or C-C haloalkyl.

[0173] In some embodiments of compounds of Formula (VII), (VIIa), or (VIIb), R 14 is hydrogen, C 1- C6 alkyl, C 1- C6 haloalkyl, C 1- C6 deuterated alkyl, or C 1- In some embodiments of compounds of Formula (VII), (VIIa), or (VIIb), R 14 is C1-C6 alkyl or C1-C6 alkyl(cycloalkyl).

[0174] Disclosed herein is a compound of formula (VIII) below, or a pharmaceutically acceptable salt, stereoisomer, or solvate thereof: [ka] During the ceremony: R 15is C 1- C6 alkyl, C 1- C6 haloalkyl, C 1- C6 deuterated alkyl, C 1- C6 hydroxyalkyl, C 1- C6 amino alkyl, C 2- C6 alkenyl, C 2- C6 alkynyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; wherein each of the alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl independently represents one or more of oxo, deuterium, halogen, -CN, -OR b , -NR c R d , -C(=O)R a , -C(=O)OR b , -C(=O)NR c R d , C 1- C6 alkyl, or C 1- optionally substituted with C6 haloalkyl; L 3 is -O-, -NH-, or -N(CH3)-; L 4 is -NR 3 - or -C(=O)-; R 3 is hydrogen, C 1- C6 alkyl, C 1- C6 haloalkyl, or C 1- C6 deuterated alkyl; R 4 is hydrogen, deuterium, halogen, -CN, -OR b , -SR b , -S(=O)R a , -S(=O)2R a , -NO2, -NR c R d , -NHS(=O)2R a , -S(=O)2NR c R d , -C(=O)R a , -OC(=O)R a , -C(=O)OR b, -OC(=O)OR b , -C(=O)NR c R d , -OC(=O)NR c R d , -NR b C(=O)NR c R d , -NR b C(=O)R a , -NR b C(=O)OR b , C 1- C6 alkyl, C 1- C6 haloalkyl, C 1- C6 deuterated alkyl, C 1- C6 hydroxyalkyl, C 1- C6 amino alkyl, C 2- C6 alkenyl, or C 2- C6 alkynyl; or R 3 and R 4 together form an optionally substituted ring; L is a bond or -C(=O)-; Ring A is a cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; each of which is selected from the group consisting of one or more R A optionally replaced by; Each R A are independently deuterium, halogen, -CN, -OR b , -SR b , -S(=O)R a , -S(=O)2R a , -NO2, -NR c R d , -NHS(=O)2R a , -S(=O)2NR c R d , -C(=O)R a , -OC(=O)R a , -C(=O)OR b , -OC(=O)OR b , -C(=O)NR c R d , -OC(=O)NR c R d , -NR bC(=O)NR c R d , -NR b C(=O)R a , -NR b C(=O)OR b , C 1- C6 alkyl, C 1- C6 haloalkyl, C 1- C6 deuterated alkyl, C 1- C6 hydroxyalkyl, C 1- C6 amino alkyl, C 2- C6 alkenyl, C 2- C6 alkynyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; wherein each of the alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl independently represents one or more of oxo, deuterium, halogen, -CN, -OR b , -NR c R d , -C(=O)R a , -C(=O)OR b , -C(=O)NR c R d , C 1- C6 alkyl, or C 1- optionally substituted with C6 haloalkyl; or two R on the same carbon A together form oxo; X is -CR x -or-N-; R X is hydrogen, deuterium, halogen, -CN, -OR b , -SR b , -S(=O)R a , -S(=O)2R a , -NO2, -NR c R d , -NHS(=O)2R a , -S(=O)2NR c R d , -C(=O)R a , -OC(=O)R a , -C(=O)OR b , -OC(=O)OR b, -C(=O)NR c R d , -OC(=O)NR c R d , -NR b C(=O)NR c R d , -NR b C(=O)R a , -NR b C(=O)OR b , C 1- C6 alkyl, C 1- C6 haloalkyl, C 1- C6 deuterated alkyl, C 1- C6 hydroxyalkyl, C 1- C6 amino alkyl, C 2- C6 alkenyl, or C 2- C6 alkynyl; Each R a independently, C 1- C6 alkyl, C 1- C6 haloalkyl, C 1- C6 deuterated alkyl, C 1- C6 hydroxyalkyl, C 1- C6 amino alkyl, C 2- C6 alkenyl, C 2- C alkynyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; wherein each of the alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl independently represents one or more of oxo, deuterium, halogen, —CN, —OH, —OMe, —NH, —C(═O)Me, —C(═O)OH, —C(═O)OMe, C 1- C6 alkyl, or C 1- optionally substituted with C6 haloalkyl; R 5 is halogen, -CN, -OR 8 , -SR 8 , -S(=O)R 7 , -S(=O)2R 7 , -NO2, -NR 9 R 10 , -NHS(=O)2R 7 , -S(=O)2NR9 R 10 , -C(=O)R 7 , -OC(=O)R 7 , -C(=O)OR 8 , -OC(=O)OR 8 , -C(=O)NR 9 R 10 , -OC(=O)NR 9 R 10 , -NR 8 C(=O)NR 9 R 10 , -NR 8 C(=O)R 7 , -NR 8 C(=O)OR 8 , C 1- C6 alkyl, C 1- C6 haloalkyl, C 1- C6 deuterated alkyl, C 1- C6 hydroxyalkyl, C 1- C6 amino alkyl, C 2- C6 alkenyl, C 2- C6 alkynyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; wherein each of the alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl independently represents one or more of oxo, deuterium, halogen, -CN, -OR b , -NR c R d , -C(=O)R a , -C(=O)OR b , -C(=O)NR c R d , C1-C6 alkyl, or C 1- optionally substituted with C6 haloalkyl; or R X and R 5 together with one or more R D forming a ring D optionally substituted with; Ring D is cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; Each R D are independently hydrogen, deuterium, halogen, -CN, -OR b , -SRb , -S(=O)R a , -S(=O)2R a , -NO2, -NR c R d , -NHS(=O)2R a , -S(=O)2NR c R d , -C(=O)R a , -OC(=O)R a , -C(=O)OR b , -OC(=O)OR b , -C(=O)NR c R d , -OC(=O)NR c R d , -NR b C(=O)NR c R d , -NR b C(=O)R a , -NR b C(=O)OR b , C 1- C6 alkyl, C 1- C6 haloalkyl, C 1- C6 deuterated alkyl, C 1- C6 hydroxyalkyl, C 1- C6 amino alkyl, C 2- C6 alkenyl, C 2- C6 alkynyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; wherein each of the alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl independently represents one or more of oxo, deuterium, halogen, -CN, -OR b , -NR c R d , -C(=O)R a , -C(=O)OR b , -C(=O)NR c R d , C 1- C6 alkyl, or C 1- optionally substituted with C6 haloalkyl; or two R on the same carbon D together form oxo; R7 is C 1- C6 alkyl, C 1- C6 haloalkyl, C 1- C6 deuterated alkyl, C 1- C6 hydroxyalkyl, C 1- C6 amino alkyl, C 2- C6 alkenyl, C 2- C alkynyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; wherein each of the alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl independently represents one or more of oxo, deuterium, halogen, —CN, —OH, —OMe, —NH, —C(═O)Me, —C(═O)OH, —C(═O)OMe, C 1- C6 alkyl, or C 1- optionally substituted with C6 haloalkyl; Each R 8 are independently hydrogen, C 1- C6 alkyl, C 1- C6 haloalkyl, C 1- C6 deuterated alkyl, C 1- C6 hydroxyalkyl, C 1- C6 amino alkyl, C 2- C6 alkenyl, C 2- C alkynyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; wherein each of the alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl independently represents one or more of oxo, deuterium, halogen, —CN, —OH, —OMe, —NH, —C(═O)Me, —C(═O)OH, —C(═O)OMe, C 1- C6 alkyl, or C 1- optionally substituted with C6 haloalkyl; R 9 and R 10 are independently hydrogen, C 1- C6 alkyl, C 1- C6 haloalkyl, C 1- C6 deuterated alkyl, C 1- C6 hydroxyalkyl, C 1-C6 amino alkyl, C 2- C6 alkenyl, C 2- C alkynyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; wherein each of the alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl independently represents one or more of oxo, deuterium, halogen, —CN, —OH, —OMe, —NH, —C(═O)Me, —C(═O)OH, —C(═O)OMe, C 1- C6 alkyl, or C 1- optionally substituted with C6 haloalkyl; or R 9 and R 10 together with the nitrogen atom to which they are attached, one or more of oxo, deuterium, halogen, -CN, -OH, -OMe, -NH2, -C(=O)Me, -C(=O)OH, -C(=O)OMe, C 1- C6 alkyl, or C 1- forming a heterocycloalkyl optionally substituted with C6 haloalkyl; Each R b are independently hydrogen, C 1- C6 alkyl, C 1- C6 haloalkyl, C 1- C6 deuterated alkyl, C 1- C6 hydroxyalkyl, C 1- C6 amino alkyl, C 2- C6 alkenyl, C 2- C alkynyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; wherein each of the alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl independently represents one or more of oxo, deuterium, halogen, —CN, —OH, —OMe, —NH, —C(═O)Me, —C(═O)OH, —C(═O)OMe, C 1- C6 alkyl, or C 1- optionally substituted with C6 haloalkyl; Each R c and R d are independently hydrogen, C 1- C6 alkyl, C1- C6 haloalkyl, C 1- C6 deuterated alkyl, C 1- C6 hydroxyalkyl, C 1- C6 amino alkyl, C 2- C6 alkenyl, C 2- C alkynyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; wherein each of the alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl independently represents one or more of oxo, deuterium, halogen, —CN, —OH, —OMe, —NH, —C(═O)Me, —C(═O)OH, —C(═O)OMe, C 1- C6 alkyl, or C 1- optionally substituted with C6 haloalkyl; or R c and R d together with the nitrogen atom to which they are attached, one or more of oxo, deuterium, halogen, -CN, -OH, -OMe, -NH2, -C(=O)Me, -C(=O)OH, -C(=O)OMe, C 1- C6 alkyl, or C 1- forming a heterocycloalkyl optionally substituted with C6 haloalkyl;

[0175] In some embodiments of the compound of Formula (VIII), L is a bond. In some embodiments of the compound of Formula (VIII), L is -C(=O)-.

[0176] In some embodiments of compounds of Formula (VIII), ring A is heterocycloalkyl or heteroaryl; each of which contains one or more R A In some embodiments of compounds of Formula (VIII), ring A is a 5-membered heterocycloalkyl or a 5-membered heteroaryl; each optionally substituted with one or more R A In some embodiments of the compound of Formula (VIII), ring A is optionally substituted with one or more R A is heteroaryl optionally substituted with

[0177] In some embodiments of the compound of Formula (VIII), each R A are independently deuterium, halogen, -CN, -OR b , -NR c R d , -C(=O)R a , -C(=O)OR b , -C(=O)NR c R d , -OC(=O)NR c R d , C 1- C6 alkyl, C 1- C6 haloalkyl, or C 1- In some embodiments of the compound of Formula (VIII), each R A is independently deuterium, halogen, C-C alkyl, C-C haloalkyl, or C-C deuterated alkyl. In some embodiments of compounds of Formula (VIII), each R A is independently halogen or C1-C6 alkyl. In some embodiments of compounds of Formula (VIII), each R A are independently C1-C6 alkyl.

[0178] In some embodiments of the compound of Formula (VIII), R 4 is hydrogen, deuterium, halogen, -CN, -OR b , -NR c R d , -C(=O)R a , -C(=O)OR b , -C(=O)NR c R d , -OC(=O)NR c R d , C 1- C6 alkyl, C 1- C6 haloalkyl, or C 1- In some embodiments of the compound of formula (VIII), R 4 is hydrogen or -OR b In some embodiments of the compound of Formula (VIII), R 4 -OR b In some embodiments of the compound of Formula (VIII), R4 is hydrogen.

[0179] In some embodiments of the compound of Formula (VIII), X is -CH-. In some embodiments of the compound of Formula (VIII), X is -N-.

[0180] In some embodiments of the compound of Formula (VIII), the compound is a compound of Formula (VIIIa): [ka]

[0181] In some embodiments of the compound of Formula (VIII), the compound is a compound of Formula (VIIIb): [ka]

[0182] In some embodiments of compounds of Formula (VIII), (VIIIa) or (VIIIb), R 5 is halogen, -CN, -OR 8 , -NR 9 R 10 , -C(=O)R 7 , -C(=O)OR 8 , -C(=O)NR 9 R 10 , -NR 8 C(=O)NR 9 R 10 , -NR 8 C(=O)R 7 , -NR 8 C(=O)OR 8 , C 1- C6 alkyl, C 1- C6 haloalkyl, C 1- C6 deuterated alkyl, C 2- C6 alkenyl, C 2-C alkynyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; wherein each of the alkyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl independently represents one or more of oxo, deuterium, halogen, -CN, -OR b , -NR c R d , -C(=O)R a , -C(=O)OR b , -C(=O)NR c R d , C 1- C6 alkyl, or C 1- Optionally substituted with C6 haloalkyl.

[0183] In some embodiments of compounds of Formula (VIII), (VIIIa), or (VIIIb), R 5 -OR 8 , -NR 9 R 10 , -C(=O)R 7 , -C(=O)OR 8 , -C(=O)NR 9 R 10 , -NR 8 C(=O)NR 9 R 10 , -NR 8 C(=O)R 7 , -NR 8 C(=O)OR 8 , cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; wherein each of the cycloalkyl, heterocycloalkyl, aryl, and heteroaryl independently represents one or more of oxo, deuterium, halogen, —CN, —OR b , -NR c R d , -C(=O)R a , -C(=O)OR b , -C(=O)NR c R d , C1-C6 alkyl, or C1-C6 haloalkyl.

[0184] In some embodiments of compounds of Formula (VIII), (VIIIa) or (VIIIb), R 5 -OR 8 , -NR 9 R 10 , -NR 8 C(=O)R 7 , or one or more of oxo, deuterium, halogen, -CN, -OR b , -NR c R d , -C(=O)R a , -C(=O)OR b , -C(=O)NR c R d , C1-C6 alkyl, or C1-C6 haloalkyl.

[0185] In some embodiments of compounds of Formula (VIII), (VIIIa), or (VIIIb), R 5 -OR 8 , -NR 9 R 10 , -NR 8 C(=O)R 7 , cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; wherein each of the cycloalkyl, heterocycloalkyl, aryl, and heteroaryl independently represents one or more of oxo, deuterium, halogen, —CN, —OR b , -NR c R d , -C(=O)R a , -C(=O)OR b , -C(=O)NR c R d , C1-C6 alkyl, or C1-C6 haloalkyl. In some embodiments of compounds of Formula (VIII), (VIIIa), or (VIIIb), R 5 is -NR 8 C(=O)R 7 In some embodiments of compounds of Formula (VIII), (VIIIa) or (VIIIb), R 5 is one or more of oxo, deuterium, halogen, -CN, -OR b , -NRc R d , -C(=O)R a , -C(=O)OR b , -C(=O)NR c R d , C1-C6 alkyl, or C1-C6 haloalkyl.

[0186] In some embodiments of compounds of Formula (VIII), (VIIIa) or (VIIIb), R 7 is C-C alkyl, C-C haloalkyl, C-C deuterated alkyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; wherein each of the alkyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl is independently optionally substituted with one or more oxo, deuterium, halogen, —CN, —OH, —OMe, —NH, —C(═O)Me, —C(═O)OH, —C(═O)OMe, C-C alkyl, or C-C haloalkyl. In some embodiments of compounds of Formula (VIII), (VIIIa), or (VIIIb), R 7 is C-C alkyl, C-C haloalkyl, C-C deuterated alkyl, or cycloalkyl; wherein each of the alkyl, cycloalkyl, and heterocycloalkyl is independently optionally substituted with one or more oxo, deuterium, halogen, -CN, -OH, -OMe, -NH, -C(=O)Me, -C(=O)OH, -C(=O)OMe, C-C alkyl, or C-C haloalkyl. In some embodiments of compounds of Formula (VIII), (VIIIa), or (VIIIb), R 7 is cycloalkyl optionally substituted with one or more oxo, deuterium, halogen, —CN, —OH, —OMe, —NH, —C(═O)Me, —C(═O)OH, —C(═O)OMe, C-C alkyl, or C-C haloalkyl. In some embodiments of compounds of Formula (VIII), (VIIIa), or (VIIIb), R 7 is an unsubstituted cycloalkyl.

[0187] In some embodiments of compounds of Formula (VIII), (VIIIa) or (VIIIb), R 8 is hydrogen, C-C alkyl, C-C haloalkyl, C-C deuterated alkyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; wherein each of the alkyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl is independently optionally substituted with one or more oxo, deuterium, halogen, —CN, —OH, —OMe, —NH, —C(═O)Me, —C(═O)OH, —C(═O)OMe, C-C alkyl, or C-C haloalkyl. In some embodiments of compounds of Formula (VIII), (VIIIa), or (VIIIb), R 8 is hydrogen, C-C alkyl, C-C haloalkyl, C-C deuterated alkyl, or cycloalkyl; wherein each of alkyl, cycloalkyl, and heterocycloalkyl is independently optionally substituted with one or more oxo, deuterium, halogen, —CN, —OH, —OMe, —NH, —C(═O)Me, —C(═O)OH, —C(═O)OMe, C-C alkyl, or C-C haloalkyl.

[0188] In some embodiments of compounds of Formula (VIII), (VIIIa) or (VIIIb), R 9 and R 10 is independently hydrogen, C-C alkyl, C-C haloalkyl, C-C deuterated alkyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; wherein each of the alkyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl is independently optionally substituted with one or more oxo, deuterium, halogen, —CN, —OH, —OMe, —NH, —C(═O)Me, —C(═O)OH, —C(═O)OMe, C-C alkyl, or C-C haloalkyl. In some embodiments of compounds of Formula (VIII), (VIIIa), or (VIIIb), R 9 and R 10are independently hydrogen, C-C alkyl, C-C haloalkyl, C-C deuterated alkyl, or cycloalkyl; wherein each of alkyl, cycloalkyl, and heterocycloalkyl is independently optionally substituted with one or more oxo, deuterium, halogen, —CN, —OH, —OMe, —NH, —C(═O)Me, —C(═O)OH, —C(═O)OMe, C-C alkyl, or C-C haloalkyl.

[0189] In some embodiments of compounds of Formula (VIII), (VIIIa) or (VIIIb), L 3 In some embodiments of compounds of Formula (VIII), (VIIIa) or (VIIIb), L 3 is -NH-.

[0190] In some embodiments of compounds of Formula (VIII), (VIIIa) or (VIIIb), R 15 is C1-C6 alkyl, C1-C6 haloalkyl, C1-C6 deuterated alkyl, or cycloalkyl.

[0191] In some embodiments of compounds of Formula (VIII), (VIIIa) or (VIIIb), L 4 is -NR 3 -It is.

[0192] In some embodiments of compounds of Formula (VIII), (VIIIa) or (VIIIb), R 3 is hydrogen or C1-C6 alkyl. In some embodiments of compounds of Formula (VIII), (VIIIa) or (VIIIb), R 3 is hydrogen.

[0193] In some embodiments of compounds of Formula (VIII), (VIIIa) or (VIIIb), L 4 is -C(=O)-.

[0194] A compound of formula (IX): or a pharmaceutically acceptable salt, solvate or stereoisomer thereof: [ka] During the ceremony: Ring F is heterocycloalkyl or heteroaryl; Each R F are independently hydrogen, deuterium, halogen, -CN, -OR b , -SR b , -S(=O)R a , -S(=O)2R a , -NO2, -NR c R d , -NHS(=O)2R a , -S(=O)2NR c R d , -C(=O)R a , -OC(=O)R a , -C(=O)OR b , -OC(=O)OR b , -C(=O)NR c R d , -OC(=O)NR c R d , -NR b C(=O)NR c R d , -NR b C(=O)R a , -NR b C(=O)OR b , C 1- C6 alkyl, C 1- C6 haloalkyl, C 1- C6 deuterated alkyl, C 1- C6 hydroxyalkyl, C 1- C6 amino alkyl, C 2- C6 alkenyl, or C 2- C6 alkynyl; or two R on the same carbon F together form oxo; or two R on adjacent atoms F together form a cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; each of which may be one or more of deuterium, oxo, halogen, -CN, -OR b , -NR cR d , -C(=O)R a , -C(=O)OR b , -C(=O)NR c R d , C 1- C6 alkyl, C 1- C6 deuterated alkyl, or C 1- optionally substituted with C6 haloalkyl; p is 0 to 4; R 3 is hydrogen, C 1- C6 alkyl, C 1- C6 haloalkyl, or C 1- C6 deuterated alkyl; R 4 is hydrogen, deuterium, halogen, -CN, -OR b , -SR b , -S(=O)R a , -S(=O)2R a , -NO2, -NR c R d , -NHS(=O)2R a , -S(=O)2NR c R d , -C(=O)R a , -OC(=O)R a , -C(=O)OR b , -OC(=O)OR b , -C(=O)NR c R d , -OC(=O)NR c R d , -NR b C(=O)NR c R d , -NR b C(=O)R a , -NR b C(=O)OR b , C 1- C6 alkyl, C 1- C6 haloalkyl, C 1- C6 deuterated alkyl, C 1- C6 hydroxyalkyl, C 1- C6 amino alkyl, C 2- C6 alkenyl, or C 2- C6 alkynyl; or R 3 and R 4 together form an optionally substituted ring; L is a bond or -C(=O)-; Ring A is a cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; each of which is selected from the group consisting of one or more R A optionally replaced by; Each R A are independently deuterium, halogen, -CN, -OR b , -SR b , -S(=O)R a , -S(=O)2R a , -NO2, -NR c R d , -NHS(=O)2R a , -S(=O)2NR c R d , -C(=O)R a , -OC(=O)R a , -C(=O)OR b , -OC(=O)OR b , -C(=O)NR c R d , -OC(=O)NR c R d , -NR b C(=O)NR c R d , -NR b C(=O)R a , -NR b C(=O)OR b , C 1- C6 alkyl, C 1- C6 haloalkyl, C 1- C6 deuterated alkyl, C 1- C6 hydroxyalkyl, C 1- C6 amino alkyl, C 2- C6 alkenyl, C 2-C6 alkynyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; wherein each of the alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl independently represents one or more of oxo, deuterium, halogen, -CN, -OR b , -NR c R d , -C(=O)R a , -C(=O)OR b , -C(=O)NR c R d , C 1- C6 alkyl, or C 1- optionally substituted with C6 haloalkyl; or two R on the same carbon A together form oxo; X is -CR x -or-N-; R X is hydrogen, deuterium, halogen, -CN, -OR b , -SR b , -S(=O)R a , -S(=O)2R a , -NO2, -NR c R d , -NHS(=O)2R a , -S(=O)2NR c R d , -C(=O)R a , -OC(=O)R a , -C(=O)OR b , -OC(=O)OR b , -C(=O)NR c R d , -OC(=O)NR c R d , -NR b C(=O)NR c R d , -NR b C(=O)R a , -NR b C(=O)OR b , C 1- C6 alkyl, C 1- C6 haloalkyl, C 1-C6 deuterated alkyl, C 1- C6 hydroxyalkyl, C 1- C6 amino alkyl, C 2- C6 alkenyl, or C 2- C6 alkynyl; R 5 is halogen, -CN, -OR 8 , -SR 8 , -S(=O)R 7 , -S(=O)2R 7 , -NO2, -NR 9 R 10 , -NHS(=O)2R 7 , -S(=O)2NR 9 R 10 , -C(=O)R 7 , -OC(=O)R 7 , -C(=O)OR 8 , -OC(=O)OR 8 , -C(=O)NR 9 R 10 , -OC(=O)NR 9 R 10 , -NR 8 C(=O)NR 9 R 10 , -NR 8 C(=O)R 7 , -NR 8 C(=O)OR 8 , C 1- C6 alkyl, C 1- C6 haloalkyl, C 1- C6 deuterated alkyl, C 1- C6 hydroxyalkyl, C 1- C6 amino alkyl, C 2- C6 alkenyl, C 2- C6 alkynyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; wherein each of the alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl independently represents one or more of oxo, deuterium, halogen, -CN, -OR b , -NR c R d , -C(=O)R a , -C(=O)ORb , -C(=O)NR c R d , C1-C6 alkyl, or C 1- optionally substituted with C6 haloalkyl; or R X and R 5 together with one or more R D forming a ring D optionally substituted with; Ring D is cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; Each R D are independently hydrogen, deuterium, halogen, -CN, -OR b , -SR b , -S(=O)R a , -S(=O)2R a , -NO2, -NR c R d , -NHS(=O)2R a , -S(=O)2NR c R d , -C(=O)R a , -OC(=O)R a , -C(=O)OR b , -OC(=O)OR b , -C(=O)NR c R d , -OC(=O)NR c R d , -NR b C(=O)NR c R d , -NR b C(=O)R a , -NR b C(=O)OR b , C 1- C6 alkyl, C 1- C6 haloalkyl, C 1- C6 deuterated alkyl, C 1- C6 hydroxyalkyl, C 1- C6 amino alkyl, C 2- C6 alkenyl, C 2-C6 alkynyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; wherein each of the alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl independently represents one or more of oxo, deuterium, halogen, -CN, -OR b , -NR c R d , -C(=O)R a , -C(=O)OR b , -C(=O)NR c R d , C 1- C6 alkyl, or C 1- optionally substituted with C6 haloalkyl; or two R on the same carbon D together form oxo; R 7 is C 1- C6 alkyl, C 1- C6 haloalkyl, C 1- C6 deuterated alkyl, C 1- C6 hydroxyalkyl, C 1- C6 amino alkyl, C 2- C6 alkenyl, C 2- C alkynyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; wherein each of the alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl independently represents one or more of oxo, deuterium, halogen, —CN, —OH, —OMe, —NH, —C(═O)Me, —C(═O)OH, —C(═O)OMe, C 1- C6 alkyl, or C 1- optionally substituted with C6 haloalkyl; Each R 8 are independently hydrogen, C 1- C6 alkyl, C 1- C6 haloalkyl, C 1- C6 deuterated alkyl, C 1- C6 hydroxyalkyl, C 1- C6 amino alkyl, C 2- C6 alkenyl, C 2-C alkynyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; wherein each of the alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl independently represents one or more of oxo, deuterium, halogen, —CN, —OH, —OMe, —NH, —C(═O)Me, —C(═O)OH, —C(═O)OMe, C 1- C6 alkyl, or C 1- optionally substituted with C6 haloalkyl; R 9 and R 10 are independently hydrogen, C 1- C6 alkyl, C 1- C6 haloalkyl, C 1- C6 deuterated alkyl, C 1- C6 hydroxyalkyl, C 1- C6 amino alkyl, C 2- C6 alkenyl, C 2- C alkynyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; wherein each of the alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl independently represents one or more of oxo, deuterium, halogen, —CN, —OH, —OMe, —NH, —C(═O)Me, —C(═O)OH, —C(═O)OMe, C 1- C6 alkyl, or C 1- optionally substituted with C6 haloalkyl; or R 9 and R 10 together with the nitrogen atom to which they are attached, one or more of oxo, deuterium, halogen, -CN, -OH, -OMe, -NH2, -C(=O)Me, -C(=O)OH, -C(=O)OMe, C 1- C6 alkyl, or C 1- forming a heterocycloalkyl optionally substituted with C6 haloalkyl; Each R a independently, C 1- C6 alkyl, C 1- C6 haloalkyl, C 1- C6 deuterated alkyl, C1- C6 hydroxyalkyl, C 1- C6 amino alkyl, C 2- C6 alkenyl, C 2- C alkynyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; wherein each of the alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl independently represents one or more of oxo, deuterium, halogen, —CN, —OH, —OMe, —NH, —C(═O)Me, —C(═O)OH, —C(═O)OMe, C 1- C6 alkyl, or C 1- optionally substituted with C6 haloalkyl; Each R b are independently hydrogen, C 1- C6 alkyl, C 1- C6 haloalkyl, C 1- C6 deuterated alkyl, C 1- C6 hydroxyalkyl, C 1- C6 amino alkyl, C 2- C6 alkenyl, C 2- C alkynyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; wherein each of the alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl independently represents one or more of oxo, deuterium, halogen, —CN, —OH, —OMe, —NH, —C(═O)Me, —C(═O)OH, —C(═O)OMe, C 1- C6 alkyl, or C 1- optionally substituted with C6 haloalkyl; Each R c and R d are independently hydrogen, C 1- C6 alkyl, C 1- C6 haloalkyl, C 1- C6 deuterated alkyl, C 1- C6 hydroxyalkyl, C 1- C6 amino alkyl, C 2- C6 alkenyl, C 2-C alkynyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; wherein each of the alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl independently represents one or more of oxo, deuterium, halogen, —CN, —OH, —OMe, —NH, —C(═O)Me, —C(═O)OH, —C(═O)OMe, C 1- C6 alkyl, or C 1- optionally substituted with C6 haloalkyl; or R c and R d together with the nitrogen atom to which they are attached, one or more of oxo, deuterium, halogen, -CN, -OH, -OMe, -NH2, -C(=O)Me, -C(=O)OH, -C(=O)OMe, C 1- C6 alkyl, or C 1- forming a heterocycloalkyl optionally substituted with C6 haloalkyl;

[0195] In some embodiments of the compound of Formula (IX), L is a bond. In some embodiments of the compound of Formula (IX), L is -C(=O)-.

[0196] In some embodiments of compounds of Formula (IX), ring A is heterocycloalkyl or heteroaryl; each of which contains one or more R A In some embodiments of compounds of Formula (IX), ring A is a 5-membered heterocycloalkyl or a 5-membered heteroaryl; each optionally substituted with one or more R A In some embodiments of the compound of Formula (IX), ring A is optionally substituted with one or more R A is heteroaryl optionally substituted with

[0197] In some embodiments of the compound of Formula (IX), each R A are independently deuterium, halogen, -CN, -OR b , -NR c R d , -C(=O)R a , -C(=O)OR b, -C(=O)NR c R d , -OC(=O)NR c R d , C 1- C6 alkyl, C 1- C6 haloalkyl, or C 1- In some embodiments of the compound of formula (IX), each R A is independently deuterium, halogen, C-C alkyl, C-C haloalkyl, or C-C deuterated alkyl. In some embodiments of compounds of Formula (IX), each R A is independently halogen or C1-C6 alkyl. In some embodiments of compounds of Formula (IX), each R A are independently C1-C6 alkyl.

[0198] In some embodiments of the compound of Formula (IX), R 4 is hydrogen, deuterium, halogen, -CN, -OR b , -NR c R d , -C(=O)R a , -C(=O)OR b , -C(=O)NR c R d , -OC(=O)NR c R d , C 1- C6 alkyl, C 1- C6 haloalkyl, or C 1- In some embodiments of the compound of formula (IX), R 4 is hydrogen or -OR b In some embodiments of the compound of Formula (IX), R 4 -OR b In some embodiments of the compound of Formula (IX), R 4 is hydrogen.

[0199] In some embodiments of the compound of Formula (IX), X is -CH-. In some embodiments of the compound of Formula (IX), X is -N-.

[0200] In some embodiments of the compound of Formula (IX), the compound is a compound of Formula (IXa): [ka]

[0201] In some embodiments of the compound of Formula (IX), the compound is a compound of Formula (IXb): [ka]

[0202] In some embodiments of compounds of Formula (IX), (IXa) or (IXb), R 3 is hydrogen or C1-C6 alkyl. In some embodiments of compounds of Formula (IX), (IXa) or (IXb), R 3 is hydrogen.

[0203] In some embodiments of compounds of Formula (IX), (IXa) or (IXb), R 5 is halogen, -CN, -OR 8 , -NR 9 R 10 , -C(=O)R 7 , -C(=O)OR 8 , -C(=O)NR 9 R 10 , -NR 8 C(=O)NR 9 R 10 , -NR 8 C(=O)R 7 , -NR 8 C(=O)OR 8 , C 1- C6 alkyl, C 1- C6 haloalkyl, C 1- C6 deuterated alkyl, C 2- C6 alkenyl, C 2-C alkynyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; wherein each of the alkyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl independently represents one or more of oxo, deuterium, halogen, -CN, -OR b , -NR c R d , -C(=O)R a , -C(=O)OR b , -C(=O)NR c R d , C 1- C6 alkyl, or C 1- Optionally substituted with C6 haloalkyl.

[0204] In some embodiments of compounds of Formula (IX), (IXa), or (IXb), R 5 -OR 8 , -NR 9 R 10 , -C(=O)R 7 , -C(=O)OR 8 , -C(=O)NR 9 R 10 , -NR 8 C(=O)NR 9 R 10 , -NR 8 C(=O)R 7 , -NR 8 C(=O)OR 8 , cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; wherein each of the cycloalkyl, heterocycloalkyl, aryl, and heteroaryl independently represents one or more of oxo, deuterium, halogen, —CN, —OR b , -NR c R d , -C(=O)R a , -C(=O)OR b , -C(=O)NR c R d , C1-C6 alkyl, or C1-C6 haloalkyl.

[0205] In some embodiments of compounds of Formula (IX), (IXa) or (IXb), R 5 -OR 8 , -NR 9 R 10 , -NR 8 C(=O)R 7 , or one or more of oxo, deuterium, halogen, -CN, -OR b , -NR c R d , -C(=O)R a , -C(=O)OR b , -C(=O)NR c R d , C1-C6 alkyl, or C1-C6 haloalkyl.

[0206] In some embodiments of compounds of Formula (IX), (IXa), or (IXb), R 5 -OR 8 , -NR 9 R 10 , -NR 8 C(=O)R 7 , cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; wherein each of the cycloalkyl, heterocycloalkyl, aryl, and heteroaryl independently represents one or more of oxo, deuterium, halogen, —CN, —OR b , -NR c R d , -C(=O)R a , -C(=O)OR b , -C(=O)NR c R d , C1-C6 alkyl, or C1-C6 haloalkyl. In some embodiments of compounds of Formula (IX), (IXa), or (IXb), R 5 is -NR 8 C(=O)R 7 In some embodiments of compounds of Formula (IX), (IXa) or (IXb), R 5 is one or more of oxo, deuterium, halogen, -CN, -OR b , -NR c R d, -C(=O)R a , -C(=O)OR b , -C(=O)NR c R d , C1-C6 alkyl, or C1-C6 haloalkyl.

[0207] In some embodiments of compounds of Formula (IX), (IXa) or (IXb), R 7 is C-C alkyl, C-C haloalkyl, C-C deuterated alkyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; wherein each of the alkyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl is independently optionally substituted with one or more oxo, deuterium, halogen, —CN, —OH, —OMe, —NH, —C(═O)Me, —C(═O)OH, —C(═O)OMe, C-C alkyl, or C-C haloalkyl. In some embodiments of compounds of Formula (IX), (IXa), or (IXb), R 7 is C-C alkyl, C-C haloalkyl, C-C deuterated alkyl, or cycloalkyl; wherein each of the alkyl, cycloalkyl, and heterocycloalkyl is independently optionally substituted with one or more oxo, deuterium, halogen, —CN, —OH, —OMe, —NH, —C(═O)Me, —C(═O)OH, —C(═O)OMe, C-C alkyl, or C-C haloalkyl. In some embodiments of compounds of Formula (IX), (IXa), or (IXb), R 7 is cycloalkyl optionally substituted with one or more oxo, deuterium, halogen, —CN, —OH, —OMe, —NH, —C(═O)Me, —C(═O)OH, —C(═O)OMe, C-C alkyl, or C-C haloalkyl. In some embodiments of compounds of Formula (IX), (IXa), or (IXb), R 7 is an unsubstituted cycloalkyl.

[0208] In some embodiments of compounds of Formula (IX), (IXa) or (IXb), R8 is hydrogen, C-C alkyl, C-C haloalkyl, C-C deuterated alkyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; wherein each of the alkyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl is independently optionally substituted with one or more oxo, deuterium, halogen, —CN, —OH, —OMe, —NH, —C(═O)Me, —C(═O)OH, —C(═O)OMe, C-C alkyl, or C-C haloalkyl. In some embodiments of compounds of Formula (IX), (IXa), or (IXb), R 8 is hydrogen, C-C alkyl, C-C haloalkyl, C-C deuterated alkyl, or cycloalkyl; wherein each of alkyl, cycloalkyl, and heterocycloalkyl is independently optionally substituted with one or more oxo, deuterium, halogen, —CN, —OH, —OMe, —NH, —C(═O)Me, —C(═O)OH, —C(═O)OMe, C-C alkyl, or C-C haloalkyl.

[0209] In some embodiments of compounds of Formula (IX), (IXa) or (IXb), R 9 and R 10 is independently hydrogen, C-C alkyl, C-C haloalkyl, C-C deuterated alkyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; wherein each of the alkyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl is independently optionally substituted with one or more oxo, deuterium, halogen, —CN, —OH, —OMe, —NH, —C(═O)Me, —C(═O)OH, —C(═O)OMe, C-C alkyl, or C-C haloalkyl. In some embodiments of compounds of Formula (IX), (IXa), or (IXb), R 9 and R 10are independently hydrogen, C-C alkyl, C-C haloalkyl, C-C deuterated alkyl, or cycloalkyl; wherein each of alkyl, cycloalkyl, and heterocycloalkyl is independently optionally substituted with one or more oxo, deuterium, halogen, —CN, —OH, —OMe, —NH, —C(═O)Me, —C(═O)OH, —C(═O)OMe, C-C alkyl, or C-C haloalkyl.

[0210] In some embodiments of compounds of Formula (IX), (IXa), or (IXb), ring F is heterocycloalkyl.

[0211] In some embodiments of compounds of Formula (IX), (IXa) or (IXb), [ka] is.

[0212] In some embodiments of compounds of Formula (IX), (IXa) or (IXb), each R F are independently hydrogen, deuterium, halogen, -CN, -OR b , -NR c R d , -C(=O)R a , -C(=O)OR b , -C(=O)NR c R d , C 1- C6 alkyl, C 1- C6 haloalkyl, or C 1- In some embodiments of compounds of Formula (IX), (IXa), or (IXb), each R F are independently hydrogen, deuterium, halogen, C1-C6 alkyl, C1-C6 haloalkyl, or C1-C6 deuterated alkyl.

[0213] In some embodiments of the compound of Formula (IX), (IXa) or (IXb), p is 0. In some embodiments of the compound of Formula (IX), (IXa) or (IXb), p is 1. In some embodiments of the compound of Formula (IX), (IXa) or (IXb), p is 2. In some embodiments of the compound of Formula (IX), (IXa) or (IXb), p is 0 to 2. In some embodiments of the compound of Formula (IX), (IXa) or (IXb), p is 0 or 1. In some embodiments of the compound of Formula (IX), (IXa) or (IXb), p is 1 or 2. In some embodiments of the compound of Formula (IX), (IXa) or (IXb), p is 1 to 3.

[0214] Disclosed herein are compounds of formula (X) below, or a pharmaceutically acceptable salt, solvate, or stereoisomer thereof: [ka] During the ceremony: L 5 is optionally one or more R L5 a saturated or unsaturated linear aliphatic chain having 1 to 10 carbon atoms substituted with -NH-, -N(CH3)-, -O-, -S-, -S(=O)-, -S(=O)2-, or -P(=O)-; Each R L5 are independently deuterium, halogen, -CN, -OR b , -SR b , -S(=O)R a , -S(=O)2R a , -NO2, -NR c R d , -NHS(=O)2R a , -S(=O)2NR c R d , -C(=O)R a , -OC(=O)R a , -C(=O)OR b , -OC(=O)OR b , -C(=O)NR c Rd , -OC(=O)NR c R d , -NR b C(=O)NR c R d , -NR b C(=O)R a , -NR b C(=O)OR b , C 1- C6 alkyl, C 1- C6 haloalkyl, C 1- C6 deuterated alkyl, C 1- C6 hydroxyalkyl, C 1- C6 amino alkyl, C 2- C6 alkenyl, or C 2- C6 alkynyl; or two R on the same carbon atom L5 together form oxo; R 12 is -C(=O)NR 1 R 2 or -L 1- R 13 and; R 1 and R 2 are independently hydrogen, C 1- C6 alkyl, C 1- C6 haloalkyl, C 1- C6 deuterated alkyl, C 1- C6 hydroxyalkyl, C 1- C6 amino alkyl, C 2- C6 alkenyl, or C 2- C6 alkynyl; L 1 is -O-, -NH-, or -N(CH3)-; R 13 is C 1- C6 alkyl, C 1- C6 haloalkyl, C 1- C6 deuterated alkyl, C 1- C6 hydroxyalkyl, C 1- C6 amino alkyl, C 2- C6 alkenyl, C 2-C6 alkynyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; wherein each of the alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl independently represents one or more of oxo, deuterium, halogen, -CN, -OR b , -NR c R d , -C(=O)R a , -C(=O)OR b , -C(=O)NR c R d , C 1- C6 alkyl, or C 1- optionally substituted with C6 haloalkyl; R 3 is hydrogen, C 1- C6 alkyl, C 1- C6 haloalkyl, or C 1- C6 deuterated alkyl; R 4 is hydrogen, deuterium, halogen, -CN, -OR b , -SR b , -S(=O)R a , -S(=O)2R a , -NO2, -NR c R d , -NHS(=O)2R a , -S(=O)2NR c R d , -C(=O)R a , -OC(=O)R a , -C(=O)OR b , -OC(=O)OR b , -C(=O)NR c R d , -OC(=O)NR c R d , -NR b C(=O)NR c R d , -NR b C(=O)R a , -NR b C(=O)OR b , C 1- C6 alkyl, C 1- C6 haloalkyl, C1- C6 deuterated alkyl, C 1- C6 hydroxyalkyl, C 1- C6 amino alkyl, C 2- C6 alkenyl, or C 2- C6 alkynyl; or R 3 and R 4 together form an optionally substituted ring; L is a bond or -C(=O)-; Ring A is a cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; each of which is selected from the group consisting of one or more R A optionally replaced by; Each R A are independently deuterium, halogen, -CN, -OR b , -SR b , -S(=O)R a , -S(=O)2R a , -NO2, -NR c R d , -NHS(=O)2R a , -S(=O)2NR c R d , -C(=O)R a , -OC(=O)R a , -C(=O)OR b , -OC(=O)OR b , -C(=O)NR c R d , -OC(=O)NR c R d , -NR b C(=O)NR c R d , -NR b C(=O)R a , -NR b C(=O)OR b , C 1- C6 alkyl, C 1- C6 haloalkyl, C 1- C6 deuterated alkyl, C 1- C6 hydroxyalkyl, C 1- C6 amino alkyl, C 2- C6 alkenyl, C 2-C6 alkynyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; wherein each of the alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl independently represents one or more of oxo, deuterium, halogen, -CN, -OR b , -NR c R d , -C(=O)R a , -C(=O)OR b , -C(=O)NR c R d , C 1- C6 alkyl, or C 1- optionally substituted with C6 haloalkyl; or two R on the same carbon A together form oxo; X is -CR x -or-N-; R X is hydrogen, deuterium, halogen, -CN, -OR b , -SR b , -S(=O)R a , -S(=O)2R a , -NO2, -NR c R d , -NHS(=O)2R a , -S(=O)2NR c R d , -C(=O)R a , -OC(=O)R a , -C(=O)OR b , -OC(=O)OR b , -C(=O)NR c R d , -OC(=O)NR c R d , -NR b C(=O)NR c R d , -NR b C(=O)R a , -NR b C(=O)OR b , C 1- C6 alkyl, C 1- C6 haloalkyl, C 1-C6 deuterated alkyl, C 1- C6 hydroxyalkyl, C 1- C6 amino alkyl, C 2- C6 alkenyl, or C 2- C6 alkynyl; Each R a independently, C 1- C6 alkyl, C 1- C6 haloalkyl, C 1- C6 deuterated alkyl, C 1- C6 hydroxyalkyl, C 1- C6 amino alkyl, C 2- C6 alkenyl, C 2- C alkynyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; wherein each of the alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl independently represents one or more of oxo, deuterium, halogen, —CN, —OH, —OMe, —NH, —C(═O)Me, —C(═O)OH, —C(═O)OMe, C 1- C6 alkyl, or C 1- optionally substituted with C6 haloalkyl; Each R b are independently hydrogen, C 1- C6 alkyl, C 1- C6 haloalkyl, C 1- C6 deuterated alkyl, C 1- C6 hydroxyalkyl, C 1- C6 amino alkyl, C 2- C6 alkenyl, C 2- C alkynyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; wherein each of the alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl independently represents one or more of oxo, deuterium, halogen, —CN, —OH, —OMe, —NH, —C(═O)Me, —C(═O)OH, —C(═O)OMe, C 1- C6 alkyl, or C 1- optionally substituted with C6 haloalkyl; Each R cand R d are independently hydrogen, C 1- C6 alkyl, C 1- C6 haloalkyl, C 1- C6 deuterated alkyl, C 1- C6 hydroxyalkyl, C 1- C6 amino alkyl, C 2- C6 alkenyl, C 2- C alkynyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; wherein each of the alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl independently represents one or more of oxo, deuterium, halogen, —CN, —OH, —OMe, —NH, —C(═O)Me, —C(═O)OH, —C(═O)OMe, C 1- C6 alkyl, or C 1- optionally substituted with C6 haloalkyl; or R c and R d together with the nitrogen atom to which they are attached, one or more of oxo, deuterium, halogen, -CN, -OH, -OMe, -NH2, -C(=O)Me, -C(=O)OH, -C(=O)OMe, C 1- C6 alkyl, or C 1- forming a heterocycloalkyl optionally substituted with C6 haloalkyl;

[0215] In some embodiments of the compound of Formula (X), L is a bond. In some embodiments of the compound of Formula (X), L is -C(=O)-.

[0216] In some embodiments of compounds of Formula (X), ring A is heterocycloalkyl or heteroaryl; each of which contains one or more R A In some embodiments of compounds of Formula (X), ring A is a 5-membered heterocycloalkyl or a 5-membered heteroaryl; each optionally substituted with one or more R A In some embodiments of compounds of Formula (X), ring A is optionally substituted with one or more R A is heteroaryl optionally substituted with

[0217] In some embodiments of compounds of Formula (X), each R A are independently deuterium, halogen, -CN, -OR b , -NR c R d , -C(=O)R a , -C(=O)OR b , -C(=O)NR c R d , -OC(=O)NR c R d , C 1- C6 alkyl, C 1- C6 haloalkyl, or C 1- In some embodiments of the compound of Formula (X), each R A is independently deuterium, halogen, C-C alkyl, C-C haloalkyl, or C-C deuterated alkyl. In some embodiments of compounds of Formula (X), each R A is independently halogen or C1-C6 alkyl. In some embodiments of compounds of Formula (X), each R A are independently C1-C6 alkyl.

[0218] In some embodiments of the compound of Formula (X), R 4 is hydrogen, deuterium, halogen, -CN, -OR b , -NR c R d , -C(=O)R a , -C(=O)OR b , -C(=O)NR c R d , -OC(=O)NR c R d , C 1- C6 alkyl, C 1- C6 haloalkyl, or C 1- In some embodiments of the compound of formula (X), R 4 is hydrogen or -OR b In some embodiments of the compound of Formula (X), R 4 -OR b In some embodiments of the compound of Formula (X), R4 is hydrogen.

[0219] In some embodiments of the compound of Formula (X), X is -CH-. In some embodiments of the compound of Formula (X), X is -N-.

[0220] In some embodiments of the compound of Formula (X), the compound has the formula [ka] In some embodiments of the compound of Formula (X), the compound is a compound of the formula [ka] is a compound of

[0221] In some embodiments of the compound of Formula (X), the compound is a compound of Formula (Xa): [ka]

[0222] In some embodiments of the compound of Formula (X), the compound is a compound of Formula (Xb): [ka]

[0223] In some embodiments of the compound of Formula (X), the compound is a compound of Formula (Xa-1): [ka]

[0224] In some embodiments of the compound of Formula (X), the compound is a compound of Formula (Xb-1): [ka]

[0225] In some embodiments of compounds of Formula (X), (Xa), (Xa-1), (Xb) or (Xb-1), R 3 is hydrogen or C1-C6 alkyl. In some embodiments of compounds of Formula (X), (Xa), (Xa-1), (Xb) or (Xb-1), R 3 is hydrogen.

[0226] In some embodiments of compounds of Formula (X), (Xa), (Xa-1), (Xb) or (Xb-1), R 12 is -C(=O)NR 1 R 2 is.

[0227] In some embodiments of compounds of Formula (X), (Xa), (Xa-1), (Xb) or (Xb-1), R 1 and R 2 is independently hydrogen, C-C alkyl, C-C haloalkyl, or C-C deuterated alkyl. In some embodiments of compounds of Formula (X), (Xa), (Xa-1), (Xb) or (Xb-1), R 1 and R 2 is independently hydrogen, or C-C deuterated alkyl. In some embodiments of compounds of Formula (X), (Xa), (Xa-1), (Xb) or (Xb-1), R 1 is hydrogen. In some embodiments of compounds of Formula (X), (Xa), (Xa-1), (Xb) or (Xb-1), R 2 is C1-C6 alkyl or C1-C6 deuterated alkyl. In some embodiments of compounds of Formula (X), (Xa), (Xa-1), (Xb) or (Xb-1), R 2 is a C1-C6 deuterated alkyl.

[0228] In some embodiments of compounds of Formula (X), (Xa), (Xa-1), (Xb) or (Xb-1), R 12 -L 1 -R 13 is.

[0229] In some embodiments of compounds of Formula (X), (Xa), (Xa-1), (Xb) or (Xb-1), L 1 In some embodiments of compounds of Formula (X), (Xa), (Xa-1), (Xb) or (Xb-1), L 1 is —O— or —NH—.

[0230] In some embodiments of compounds of Formula (X), (Xa), (Xa-1), (Xb) or (Xb-1), R 13 is C1-C6 alkyl, C1-C6 haloalkyl, or C1-C6 deuterated alkyl.

[0231] In some embodiments of compounds of Formula (X), (Xa), (Xa-1), (Xb) or (Xb-1), L 5 is one or more R L5 A saturated linear aliphatic chain having 1 to 8 carbon atoms optionally substituted with, in which 1, 2, or 3 carbon atoms are optionally substituted with -NH-, -N(CH3)-, -O-, -S-, -S(=O)-, -S(=O) 2- In some embodiments of compounds of Formula (X), (Xa), (Xa-1), (Xb) or (Xb-1), L 5 is one or more R L5 In some embodiments of the compound of Formula (X), (Xa), (Xa-1), (Xb) or (Xb-1), L is a saturated linear aliphatic chain having 1 to 8 carbon atoms optionally substituted with -NH-, -N(CH3)-, or -O-. 5 is one or more R L5 is a saturated linear aliphatic chain having 1 to 8 carbon atoms optionally substituted with -NH- or -O-, in which 1, 2, or 3 carbon atoms are optionally replaced with -NH- or -O-.

[0232] In some embodiments of compounds of Formula (X), (Xa), (Xa-1), (Xb) or (Xb-1), L 5is a saturated linear aliphatic chain having 1 to 8 carbon atoms, wherein 1, 2, or 3 carbon atoms are optionally replaced with -NH-, -N(CH3)-, -O-, -S-, -S(=O)-, or -S(=O)2-. In some embodiments of compounds of Formula (X), (Xa), (Xa-1), (Xb) or (Xb-1), L 5 is a saturated linear aliphatic chain having 1 to 8 carbon atoms, wherein 1, 2, or 3 carbon atoms are optionally replaced with -NH-, -N(CH3)-, or -O-. In some embodiments of compounds of Formula (X), (Xa), (Xa-1), (Xb) or (Xb-1), L 5 is a saturated linear aliphatic chain having 1 to 8 carbon atoms, in which 1, 2, or 3 carbon atoms are optionally replaced by -NH-, or -O-.

[0233] In some embodiments of compounds of Formula (X), (Xa), (Xa-1), (Xb) or (Xb-1), L 5 is one or more R L5 In some embodiments of the compound of Formula (X), (Xa), (Xa-1), (Xb) or (Xb-1), L is an unsaturated linear aliphatic chain having 1 to 8 carbon atoms optionally substituted with -NH-, -N(CH3)-, -O-, -S-, -S(=O)-, or -S(=O)2-. 5 is one or more R L5 In some embodiments of the compound of Formula (X), (Xa), (Xa-1), (Xb) or (Xb-1), L is an unsaturated linear aliphatic chain having 1 to 8 carbon atoms optionally substituted with -NH-, -N(CH3)-, or -O-. 5 is one or more R L5 is an unsaturated linear aliphatic chain having 1 to 8 carbon atoms optionally substituted with -NH- or -O-, in which 1, 2, or 3 carbon atoms are optionally replaced with -NH- or -O-.

[0234] In some embodiments of compounds of Formula (X), (Xa), (Xa-1), (Xb) or (Xb-1), L 5 is an unsaturated linear aliphatic chain having 1 to 8 carbon atoms, wherein 1, 2, or 3 carbon atoms are optionally replaced by -NH-, -N(CH3)-, -O-, -S-, -S(=O)-, -S(=O)2-, or -P(=O)-. In some embodiments of compounds of Formula (X), (Xa), (Xa-1), (Xb) or (Xb-1), L 5 is an unsaturated linear aliphatic chain having 1 to 8 carbon atoms, wherein 1, 2, or 3 carbon atoms are optionally replaced with -NH-, -N(CH3)-, or -O-. In some embodiments of compounds of Formula (X), (Xa), (Xa-1), (Xb) or (Xb-1), L 5 is an unsaturated linear aliphatic chain having 1 to 8 carbon atoms, in which 1, 2, or 3 carbon atoms are optionally replaced by -NH-, or -O-.

[0235] In some embodiments of compounds of Formula (X), (Xa), (Xa-1), (Xb) or (Xb-1), each R L5 are independently deuterium, halogen, -CN, -OR b , -NR c R d , -C(=O)R a , -C(=O)OR b , -C(=O)NR c R d , C 1- C6 alkyl, C 1- C6 haloalkyl, or C 1- In some embodiments of compounds of Formula (X), (Xa), (Xa-1), (Xb) or (Xb-1), each R L5 is independently deuterium, halogen, C-C alkyl, C-C haloalkyl, or C-C deuterated alkyl. In some embodiments of compounds of Formula (X), (Xa), (Xa-1), (Xb) or (Xb-1), each R L5 are independently deuterium or halogen.

[0236] In some embodiments of compounds of Formula (X), (Xa), (Xa-1), (Xb), or (Xb-1), two R L5 together form oxo.

[0237] In some embodiments of compounds of Formula (X), (Xa), (Xa-1), (Xb) or (Xb-1), L 5 teeth, [ka] is.

[0238] Disclosed herein is a compound of formula (XI) below, or a pharmaceutically acceptable salt, solvate, or stereoisomer thereof: [ka] During the ceremony: L 6 is optionally one or more R L6 a saturated or unsaturated linear aliphatic chain having 1 to 10 carbon atoms substituted with -NH-, -N(CH3)-, -O-, -S-, -S(=O)-, -S(=O)2-, or -P(=O)-; Each R L6 are independently deuterium, halogen, -CN, -OR b , -SR b , -S(=O)R a , -S(=O)2R a , -NO2, -NR c R d , -NHS(=O)2R a , -S(=O)2NR c R d , -C(=O)R a , -OC(=O)R a , -C(=O)OR b , -OC(=O)OR b , -C(=O)NR c R d , -OC(=O)NRc R d , -NR b C(=O)NR c R d , -NR b C(=O)R a , -NR b C(=O)OR b , C 1- C6 alkyl, C 1- C6 haloalkyl, C 1- C6 deuterated alkyl, C 1- C6 hydroxyalkyl, C 1- C6 amino alkyl, C 2- C6 alkenyl, or C 2- C6 alkynyl; or two R on the same carbon atom L6 together form oxo; R 3 is hydrogen, C 1- C6 alkyl, C 1- C6 haloalkyl, or C 1- C6 deuterated alkyl; R 4 is hydrogen, deuterium, halogen, -CN, -OR b , -SR b , -S(=O)R a , -S(=O)2R a , -NO2, -NR c R d , -NHS(=O)2R a , -S(=O)2NR c R d , -C(=O)R a , -OC(=O)R a , -C(=O)OR b , -OC(=O)OR b , -C(=O)NR c R d , -OC(=O)NR c R d , -NR b C(=O)NR c R d , -NR b C(=O)R a , -NR b C(=O)OR b, C 1- C6 alkyl, C 1- C6 haloalkyl, C 1- C6 deuterated alkyl, C 1- C6 hydroxyalkyl, C 1- C6 amino alkyl, C 2- C6 alkenyl, or C 2- C6 alkynyl; or R 3 and R 4 together form an optionally substituted ring; L is a bond or -C(=O)-; Ring A is a cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; each of which is selected from the group consisting of one or more R A optionally replaced by; Each R A are independently deuterium, halogen, -CN, -OR b , -SR b , -S(=O)R a , -S(=O)2R a , -NO2, -NR c R d , -NHS(=O)2R a , -S(=O)2NR c R d , -C(=O)R a , -OC(=O)R a , -C(=O)OR b , -OC(=O)OR b , -C(=O)NR c R d , -OC(=O)NR c R d , -NR b C(=O)NR c R d , -NR b C(=O)R a , -NR b C(=O)OR b , C 1- C6 alkyl, C 1- C6 haloalkyl, C 1- C6 deuterated alkyl, C 1- C6 hydroxyalkyl, C 1- C6 amino alkyl, C2- C6 alkenyl, C 2- C6 alkynyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; wherein each of the alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl independently represents one or more of oxo, deuterium, halogen, -CN, -OR b , -NR c R d , -C(=O)R a , -C(=O)OR b , -C(=O)NR c R d , C 1- C6 alkyl, or C 1- optionally substituted with C6 haloalkyl; or two R on the same carbon A together form oxo; X is -CR x -or-N-; R X is hydrogen, deuterium, halogen, -CN, -OR b , -SR b , -S(=O)R a , -S(=O)2R a , -NO2, -NR c R d , -NHS(=O)2R a , -S(=O)2NR c R d , -C(=O)R a , -OC(=O)R a , -C(=O)OR b , -OC(=O)OR b , -C(=O)NR c R d , -OC(=O)NR c R d , -NR b C(=O)NR c R d , -NR b C(=O)R a , -NR b C(=O)OR b , C 1- C6 alkyl, C1- C6 haloalkyl, C 1- C6 deuterated alkyl, C 1- C6 hydroxyalkyl, C 1- C6 amino alkyl, C 2- C6 alkenyl, or C 2- C6 alkynyl; R 5 is hydrogen, halogen, -CN, -OR 8 , -SR 8 , -S(=O)R 7 , -S(=O)2R 7 , -NO2, -NR 9 R 10 , -NHS(=O)2R 7 , -S(=O)2NR 9 R 10 , -C(=O)R 7 , -OC(=O)R 7 , -C(=O)OR 8 , -OC(=O)OR 8 , -C(=O)NR 9 R 10 , -OC(=O)NR 9 R 10 , -NR 8 C(=O)NR 9 R 10 , -NR 8 C(=O)R 7 , -NR 8 C(=O)OR 8 ,C 1- C6 alkyl, C 1- C6 haloalkyl, C 1- C6 deuterated alkyl, C 1- C6 hydroxyalkyl, C 1- C6 amino alkyl, C 2- C6 alkenyl, C 2- C6 alkynyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; wherein each of the alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl independently represents one or more of oxo, deuterium, halogen, -CN, -OR b , -NR c R d, -C(=O)R a , -C(=O)OR b , -C(=O)NR c R d , C 1- C6 alkyl, or C 1- optionally substituted with C6 haloalkyl; or R X and R 5 together with one or more R D forming a ring D optionally substituted with; Ring D is cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; Each R D are independently hydrogen, deuterium, halogen, -CN, -OR b , -SR b , -S(=O)R a , -S(=O)2R a , -NO2, -NR c R d , -NHS(=O)2R a , -S(=O)2NR c R d , -C(=O)R a , -OC(=O)R a , -C(=O)OR b , -OC(=O)OR b , -C(=O)NR c R d , -OC(=O)NR c R d , -NR b C(=O)NR c R d , -NR b C(=O)R a , -NR b C(=O)OR b , C 1- C6 alkyl, C 1- C6 haloalkyl, C 1- C6 deuterated alkyl, C 1- C6 hydroxyalkyl, C 1- C6 amino alkyl, C 2- C6 alkenyl, C 2-C6 alkynyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; wherein each of the alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl independently represents one or more of oxo, deuterium, halogen, -CN, -OR b , -NR c R d , -C(=O)R a , -C(=O)OR b , -C(=O)NR c R d , C 1- C6 alkyl, or C 1- optionally substituted with C6 haloalkyl; or two R on the same carbon D together form oxo; R 7 is C 1- C6 alkyl, C 1- C6 haloalkyl, C 1- C6 deuterated alkyl, C 1- C6 hydroxyalkyl, C 1- C6 amino alkyl, C 2- C6 alkenyl, C 2- C alkynyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; wherein each of the alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl independently represents one or more of oxo, deuterium, halogen, —CN, —OH, —OMe, —NH, —C(═O)Me, —C(═O)OH, —C(═O)OMe, C 1- C6 alkyl, or C 1- optionally substituted with C6 haloalkyl; Each R 8 are independently hydrogen, C 1- C6 alkyl, C 1- C6 haloalkyl, C 1- C6 deuterated alkyl, C 1- C6 hydroxyalkyl, C 1- C6 amino alkyl, C 2- C6 alkenyl, C 2-C alkynyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; wherein each of the alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl independently represents one or more of oxo, deuterium, halogen, —CN, —OH, —OMe, —NH, —C(═O)Me, —C(═O)OH, —C(═O)OMe, C 1- C6 alkyl, or C 1- optionally substituted with C6 haloalkyl; R 9 and R 10 are independently hydrogen, C 1- C6 alkyl, C 1- C6 haloalkyl, C 1- C6 deuterated alkyl, C 1- C6 hydroxyalkyl, C 1- C6 amino alkyl, C 2- C6 alkenyl, C 2- C alkynyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; wherein each of the alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl independently represents one or more of oxo, deuterium, halogen, —CN, —OH, —OMe, —NH, —C(═O)Me, —C(═O)OH, —C(═O)OMe, C 1- C6 alkyl, or C 1- optionally substituted with C6 haloalkyl; or R 9 and R 10 together with the nitrogen atom to which they are attached, one or more of oxo, deuterium, halogen, -CN, -OH, -OMe, -NH2, -C(=O)Me, -C(=O)OH, -C(=O)OMe, C 1- C6 alkyl, or C 1- forming a heterocycloalkyl optionally substituted with C6 haloalkyl; Each R a independently, C 1- C6 alkyl, C 1- C6 haloalkyl, C 1- C6 deuterated alkyl, C1- C6 hydroxyalkyl, C 1- C6 amino alkyl, C 2- C6 alkenyl, C 2- C alkynyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; wherein each of the alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl independently represents one or more of oxo, deuterium, halogen, —CN, —OH, —OMe, —NH, —C(═O)Me, —C(═O)OH, —C(═O)OMe, C 1- C6 alkyl, or C 1- optionally substituted with C6 haloalkyl; Each R b are independently hydrogen, C 1- C6 alkyl, C 1- C6 haloalkyl, C 1- C6 deuterated alkyl, C 1- C6 hydroxyalkyl, C 1- C6 amino alkyl, C 2- C6 alkenyl, C 2- C alkynyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; wherein each of the alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl independently represents one or more of oxo, deuterium, halogen, —CN, —OH, —OMe, —NH, —C(═O)Me, —C(═O)OH, —C(═O)OMe, C 1- C6 alkyl, or C 1- optionally substituted with C6 haloalkyl; Each R c and R d are independently hydrogen, C 1- C6 alkyl, C 1- C6 haloalkyl, C 1- C6 deuterated alkyl, C 1- C6 hydroxyalkyl, C 1- C6 amino alkyl, C 2- C6 alkenyl, C 2-C alkynyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; wherein each of the alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl independently represents one or more of oxo, deuterium, halogen, —CN, —OH, —OMe, —NH, —C(═O)Me, —C(═O)OH, —C(═O)OMe, C 1- C6 alkyl, or C 1- optionally substituted with C6 haloalkyl; or R c and R d together with the nitrogen atom to which they are attached, one or more of oxo, deuterium, halogen, -CN, -OH, -OMe, -NH2, -C(=O)Me, -C(=O)OH, -C(=O)OMe, C 1- C6 alkyl, or C 1- forming a heterocycloalkyl optionally substituted with C6 haloalkyl;

[0239] In some embodiments of the compound of Formula (XI), L is a bond. In some embodiments of the compound of Formula (XI), L is -C(=O)-.

[0240] In some embodiments of compounds of Formula (XI), ring A is heterocycloalkyl or heteroaryl; each of which contains one or more R A In some embodiments of compounds of Formula (XI), ring A is a 5-membered heterocycloalkyl or a 5-membered heteroaryl; each optionally substituted with one or more R A In some embodiments of the compound of Formula (XI), ring A is optionally substituted with one or more R A is heteroaryl optionally substituted with

[0241] In some embodiments of the compound of Formula (XI), each R A are independently deuterium, halogen, -CN, -OR b , -NR c R d , -C(=O)R a , -C(=O)OR b, -C(=O)NR c R d , -OC(=O)NR c R d , C 1- C6 alkyl, C 1- C6 haloalkyl, or C 1- In some embodiments of the compound of formula (XI), each R A is independently deuterium, halogen, C-C alkyl, C-C haloalkyl, or C-C deuterated alkyl. In some embodiments of compounds of Formula (XI), each R A is independently halogen or C1-C6 alkyl. In some embodiments of compounds of Formula (XI), each R A are independently C1-C6 alkyl.

[0242] In some embodiments of the compound of Formula (XI), R 4 is hydrogen, deuterium, halogen, -CN, -OR b , -NR c R d , -C(=O)R a , -C(=O)OR b , -C(=O)NR c R d , -OC(=O)NR c R d , C 1- C6 alkyl, C 1- C6 haloalkyl, or C 1- In some embodiments of the compound of formula (XI), R 4 is hydrogen or -OR b In some embodiments of the compound of Formula (XI), R 4 -OR b In some embodiments of the compound of Formula (XI), R 4 is hydrogen.

[0243] In some embodiments of the compound of Formula (XI), X is -CH-. In some embodiments of the compound of Formula (XI), X is -N-.

[0244] In some embodiments of the compound of Formula (XI), the compound is a compound of Formula (XIa): [ka]

[0245] In some embodiments of the compound of Formula (XI), the compound is a compound of Formula (XIb): [ka]

[0246] In some embodiments of compounds of Formula (XI), (XIa) or (XIb), R 3 is hydrogen or C1-C6 alkyl. In some embodiments of compounds of Formula (XI), (XIa) or (XIb), R 3 is hydrogen.

[0247] In some embodiments of compounds of Formula (XI), (XIa) or (XIb), R 5 is halogen, -CN, -OR 8 , -NR 9 R 10 , -C(=O)R 7 , -C(=O)OR 8 , -C(=O)NR 9 R 10 , -NR 8 C(=O)NR 9 R 10 , -NR 8 C(=O)R 7 , -NR 8 C(=O)OR 8 , C 1- C6 alkyl, C 1- C6 haloalkyl, C 1- C6 deuterated alkyl, C 2- C6 alkenyl, C 2-C alkynyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; wherein each of the alkyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl independently represents one or more of oxo, deuterium, halogen, -CN, -OR b , -NR c R d , -C(=O)R a , -C(=O)OR b , -C(=O)NR c R d , C 1- C6 alkyl, or C 1- Optionally substituted with C6 haloalkyl.

[0248] In some embodiments of compounds of Formula (XI), (XIa) or (XIb), R 5 -OR 8 , -NR 9 R 10 , -C(=O)R 7 , -C(=O)OR 8 , -C(=O)NR 9 R 10 , -NR 8 C(=O)NR 9 R 10 , -NR 8 C(=O)R 7 , -NR 8 C(=O)OR 8 , cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; wherein each of the cycloalkyl, heterocycloalkyl, aryl, and heteroaryl independently represents one or more of oxo, deuterium, halogen, —CN, —OR b , -NR c R d , -C(=O)R a , -C(=O)OR b , -C(=O)NR c R d , C 1- C6 alkyl, or C 1- Optionally substituted with C6 haloalkyl.

[0249] In some embodiments of compounds of Formula (XI), (XIa) or (XIb), R 5 -OR 8 , -NR 9 R 10 , -NR 8 C(=O)R 7 , or one or more of oxo, deuterium, halogen, -CN, -OR b , -NR c R d , -C(=O)R a , -C(=O)OR b , -C(=O)NR c R d , C1-C6 alkyl, or C1-C6 haloalkyl.

[0250] In some embodiments of compounds of Formula (XI), (XIa) or (XIb), R 5 -OR 8 , -NR 9 R 10 , -NR 8 C(=O)R 7 , cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; wherein each of the cycloalkyl, heterocycloalkyl, aryl, and heteroaryl independently represents one or more of oxo, deuterium, halogen, —CN, —OR b , -NR c R d , -C(=O)R a , -C(=O)OR b , -C(=O)NR c R d , C1-C6 alkyl, or C1-C6 haloalkyl. In some embodiments of compounds of Formula (XI), (XIa), or (XIb), R 5 is -NR 8 C(=O)R 7 In some embodiments of compounds of Formula (XI), (XIa) or (XIb), R 5 is one or more of oxo, deuterium, halogen, -CN, -OR b , -NR c R d, -C(=O)R a , -C(=O)OR b , -C(=O)NR c R d , C1-C6 alkyl, or C1-C6 haloalkyl.

[0251] In some embodiments of compounds of Formula (XI), (XIa) or (XIb), R 7 is C-C alkyl, C-C haloalkyl, C-C deuterated alkyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; wherein each of the alkyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl is independently optionally substituted with one or more oxo, deuterium, halogen, —CN, —OH, —OMe, —NH, —C(═O)Me, —C(═O)OH, —C(═O)OMe, C-C alkyl, or C-C haloalkyl. In some embodiments of compounds of Formula (XI), (XIa), or (XIb), R 7 is C-C alkyl, C-C haloalkyl, C-C deuterated alkyl, or cycloalkyl; wherein each of the alkyl, cycloalkyl, and heterocycloalkyl is independently optionally substituted with one or more oxo, deuterium, halogen, —CN, —OH, —OMe, —NH, —C(═O)Me, —C(═O)OH, —C(═O)OMe, C-C alkyl, or C-C haloalkyl. In some embodiments of compounds of Formula (XI), (XIa), or (XIb), R 7 is cycloalkyl optionally substituted with one or more oxo, deuterium, halogen, —CN, —OH, —OMe, —NH, —C(═O)Me, —C(═O)OH, —C(═O)OMe, C-C alkyl, or C-C haloalkyl. In some embodiments of compounds of Formula (XI), (XIa), or (XIb), R 7 is an unsubstituted cycloalkyl.

[0252] In some embodiments of compounds of Formula (XI), (XIa) or (XIb), R8 is hydrogen, C-C alkyl, C-C haloalkyl, C-C deuterated alkyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; wherein each of the alkyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl is independently optionally substituted with one or more oxo, deuterium, halogen, —CN, —OH, —OMe, —NH, —C(═O)Me, —C(═O)OH, —C(═O)OMe, C-C alkyl, or C-C haloalkyl. In some embodiments of compounds of Formula (XI), (XIa), or (XIb), R 8 is hydrogen, C-C alkyl, C-C haloalkyl, C-C deuterated alkyl, or cycloalkyl; wherein each of alkyl, cycloalkyl, and heterocycloalkyl is independently optionally substituted with one or more oxo, deuterium, halogen, —CN, —OH, —OMe, —NH, —C(═O)Me, —C(═O)OH, —C(═O)OMe, C-C alkyl, or C-C haloalkyl.

[0253] In some embodiments of compounds of Formula (XI), (XIa) or (XIb), R 9 and R 10 is independently hydrogen, C-C alkyl, C-C haloalkyl, C-C deuterated alkyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; wherein each of the alkyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl is independently optionally substituted with one or more oxo, deuterium, halogen, —CN, —OH, —OMe, —NH, —C(═O)Me, —C(═O)OH, —C(═O)OMe, C-C alkyl, or C-C haloalkyl. In some embodiments of compounds of Formula (XI), (XIa), or (XIb), R 9 and R 10are independently hydrogen, C-C alkyl, C-C haloalkyl, C-C deuterated alkyl, or cycloalkyl; wherein each of alkyl, cycloalkyl, and heterocycloalkyl is independently optionally substituted with one or more oxo, deuterium, halogen, —CN, —OH, —OMe, —NH, —C(═O)Me, —C(═O)OH, —C(═O)OMe, C-C alkyl, or C-C haloalkyl.

[0254] In some embodiments of compounds of Formula (XI), (XIa) or (XIb), L 6 is one or more R L6 In some embodiments of compounds of Formula (XI), (XIa) or (XIb), L is a saturated linear aliphatic chain having 1 to 8 carbon atoms optionally substituted with -NH-, -N(CH3)-, -O-, -S-, -S(=O)-, or -S(=O)2-. 6 is one or more R L6 In some embodiments of compounds of Formula (XI), (XIa) or (XIb), L is a saturated linear aliphatic chain having 1 to 8 carbon atoms optionally substituted with -NH-, -N(CH3)-, or -O-. 6 is one or more R L6 is a saturated linear aliphatic chain having 1 to 8 carbon atoms optionally substituted with -NH- or -O-, in which 1, 2, or 3 carbon atoms are optionally replaced with -NH- or -O-.

[0255] In some embodiments of compounds of Formula (XI), (XIa) or (XIb), L 6 is a saturated linear aliphatic chain having 1 to 8 carbon atoms, wherein 1, 2, or 3 carbon atoms are optionally replaced with -NH-, -N(CH3)-, -O-, -S-, -S(=O)-, or -S(=O)2-. In some embodiments of compounds of Formula (XI), (XIa), or (XIb), L 6is a saturated linear aliphatic chain having 1 to 8 carbon atoms, wherein 1, 2, or 3 carbon atoms are optionally replaced with -NH-, -N(CH3)-, or -O-. In some embodiments of compounds of Formula (XI), (XIa), or (XIb), L 6 is a saturated linear aliphatic chain having 1 to 8 carbon atoms, in which 1, 2, or 3 carbon atoms are optionally replaced by -NH-, or -O-.

[0256] In some embodiments of compounds of Formula (XI), (XIa) or (XIb), L 6 is one or more R L6 An unsaturated linear aliphatic chain having 1 to 8 carbon atoms optionally substituted with, in which 1, 2, or 3 carbon atoms are optionally substituted with -NH-, -N(CH3)-, -O-, -S-, -S(=O)-, -S(=O) 2- In some embodiments of compounds of Formula (XI), (XIa) or (XIb), L 6 is one or more R L6 In some embodiments of compounds of Formula (XI), (XIa) or (XIb), L is an unsaturated linear aliphatic chain having 1 to 8 carbon atoms optionally substituted with -NH-, -N(CH3)-, or -O-. 6 is one or more R L6 is an unsaturated linear aliphatic chain having 1 to 8 carbon atoms optionally substituted with -NH- or -O-, in which 1, 2, or 3 carbon atoms are optionally replaced with -NH- or -O-.

[0257] In some embodiments of compounds of Formula (XI), (XIa) or (XIb), L 6is an unsaturated linear aliphatic chain having 1 to 8 carbon atoms, wherein 1, 2, or 3 carbon atoms are optionally replaced by -NH-, -N(CH3)-, -O-, -S-, -S(=O)-, -S(=O)2-, or -P(=O)-. In some embodiments of compounds of Formula (XI), (XIa), or (XIb), L 6 is an unsaturated linear aliphatic chain having 1 to 8 carbon atoms, wherein 1, 2, or 3 carbon atoms are optionally replaced with -NH-, -N(CH3)-, or -O-. In some embodiments of compounds of Formula (XI), (XIa), or (XIb), L 6 is an unsaturated linear aliphatic chain having 1 to 8 carbon atoms, in which 1, 2, or 3 carbon atoms are optionally replaced by -NH-, or -O-.

[0258] In some embodiments of compounds of Formula (XI), (XIa) or (XIb), each R L6 are independently deuterium, halogen, -CN, -OR b , -NR c R d , -C(=O)R a , -C(=O)OR b , -C(=O)NR c R d , C 1- C6 alkyl, C 1- C6 haloalkyl, or C 1- In some embodiments of compounds of Formula (XI), (XIa), or (XIb), each R L6 is independently deuterium, halogen, C-C alkyl, C-C haloalkyl, or C-C deuterated alkyl. In some embodiments of compounds of Formula (XI), (XIa), or (XIb), each R L6 are independently deuterium or halogen.

[0259] In some embodiments of compounds of Formula (XI), (XIa), or (XIb), two R L6 together form oxo.

[0260] In some embodiments of compounds of Formula (XI), (XIa) or (XIb), L 6 teeth, [ka] is.

[0261] Disclosed herein is a compound of formula (XII) below, or a pharmaceutically acceptable salt, solvate, or stereoisomer thereof: [ka] During the ceremony: Ring B is cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; R 16 is -C(=O)NR 1 R 2 , -C(=N-CN)NR 1 R 2 , -P(=O)R 1 R 2 , or -C(=O)R 11 and; R 1 and R 2 are independently hydrogen, C 1- C6 alkyl, C 1- C6 haloalkyl, C 1- C6 deuterated alkyl, C 1- C6 hydroxyalkyl, C 1- C6 amino alkyl, C 2- C6 alkenyl, or C 2- C6 alkynyl; R 3 is hydrogen, C 1- C6 alkyl, C 1- C6 haloalkyl, or C 1- C6 deuterated alkyl; R 4 is hydrogen, deuterium, halogen, -CN, -OR b , -SR b , -S(=O)R a , -S(=O)2R a , -NO2, -NR cR d , -NHS(=O)2R a , -S(=O)2NR c R d , -C(=O)R a , -OC(=O)R a , -C(=O)OR b , -OC(=O)OR b , -C(=O)NR c R d , -OC(=O)NR c R d , -NR b C(=O)NR c R d , -NR b C(=O)R a , -NR b C(=O)OR b , -P(=O)R b R b , C 1- C6 alkyl, C 1- C6 haloalkyl, C 1- C6 deuterated alkyl, C 1- C6 hydroxyalkyl, C 1- C6 amino alkyl, C 2- C6 alkenyl, or C 2- C6 alkynyl; or R 3 and R 4 together form an optionally substituted ring; L is a bond or -C(=O)-; Ring A is a cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; each of which is selected from the group consisting of one or more R A optionally replaced by; Each R A are independently deuterium, halogen, -CN, -OR b , -SR b , -S(=O)R a , -S(=O)2R a , -NO2, -NR c R d , -NHS(=O)2R a , -S(=O)2NR c R d , -C(=O)Ra , -OC(=O)R a , -C(=O)OR b , -OC(=O)OR b , -C(=O)NR c R d , -OC(=O)NR c R d , -NR b C(=O)NR c R d , -NR b C(=O)R a , -NR b C(=O)OR b , C 1- C6 alkyl, C 1- C6 haloalkyl, C 1- C6 deuterated alkyl, C 1- C6 hydroxyalkyl, C 1- C6 amino alkyl, C 2- C6 alkenyl, C 2- C6 alkynyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; wherein each of the alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl independently represents one or more of oxo, deuterium, halogen, -CN, -OR b , -NR c R d , -C(=O)R a , -C(=O)OR b , -C(=O)NR c R d , C 1- C6 alkyl, or C 1- optionally substituted with C6 haloalkyl; or two R on the same carbon A together form oxo; or -L-ring A is absent; Each X is independently -CR x -or-N-; Each R X are independently hydrogen, deuterium, halogen, -CN, -OR b , -SR b , -S(=O)R a, -S(=O)2R a , -NO2, -NR c R d , -NHS(=O)2R a , -S(=O)2NR c R d , -C(=O)R a , -OC(=O)R a , -C(=O)OR b , -OC(=O)OR b , -C(=O)NR c R d , -OC(=O)NR c R d , -NR b C(=O)NR c R d , -NR b C(=O)R a , -NR b C(=O)OR b , C 1- C6 alkyl, C 1- C6 haloalkyl, C 1- C6 deuterated alkyl, C 1- C6 hydroxyalkyl, C 1- C6 amino alkyl, C 2- C6 alkenyl, or C 2- C6 alkynyl; R 5 is halogen, -CN, -OR 8 , -SR 8 , -S(=O)R 7 , -S(=O)2R 7 , -NO2, -NR 9 R 10 , -NR 8 S(=O)R 7 , -NR 8 S(=O)2R 7 , -S(=O)2NR 9 R 10 , -C(=N-CN)R 7 ,-C(=O)R 7 , -OC(=N-CN)R 7 , -OC(=O)R 7 , -C(=N-CN)OR 8 , -C(=O)OR 8, -OC(=N-CN)OR 8 , -OC(=O)OR 8 , -C(=N-CN)NR 9 R 10 , -C(=O)NR 9 R 10 , -OC(=N-CN)NR 9 R 10 , -OC(=O)NR 9 R 10 , -NR 8 C(=N-CN)NR 9 R 10 , -NR 8 C(=O)NR 9 R 10 , -NR 8 C(=N-CN)R 7 , -NR 8 C(=N-OH)R 7 , -NR 8 C(=O)R 7 , -NR 8 C(=N-CN)OR 8 , -NR 8 C(=O)OR 8 , -NR 8 S(=O)(=NR 8 )R 7 , C 1- C6 alkyl, C 1- C6 haloalkyl, C 1- C6 deuterated alkyl, C 1- C6 hydroxyalkyl, C 1- C6 amino alkyl, C 2- C6 alkenyl, C 2- C6 alkynyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; wherein each of the alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl independently represents one or more of oxo, deuterium, halogen, -CN, -OR b , -NR c R d , -C(=O)R a , -C(=O)OR b , -C(=O)NR c R d , C 1-C6 alkyl, C 1- C6 haloalkyl, C 1- C6 deuterated alkyl, C 1- C6 hydroxyalkyl, C 1- C6 amino alkyl, C 1- C6 heteroalkyl, C 2- C6 alkenyl, C 2- C6 alkynyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, C 1- C6 alkyl (cycloalkyl), C 1- C6 alkyl (heterocycloalkyl), C 1- C6 alkyl (aryl), or C 1- and optionally substituted with C alkyl (heteroaryl); in which case each of alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl independently may be one or more of oxo, deuterium, halogen, -CN, -OR b , -NR c R d , -C(=O)R a , -C(=O)OR b , -C(=O)NR c R d , C 1- C6 alkyl, or C 1- optionally substituted with C6 haloalkyl; or R X and R 5 together with one or more R D forming a ring D optionally substituted with; Ring D is cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; Each R D are independently hydrogen, deuterium, halogen, -CN, -OR b , -SR b , -S(=O)R a , -S(=O)2R a , -NO2, -NR c R d , -NHS(=O)2R a , -S(=O)2NR c R d , -C(=O)Ra , -OC(=O)R a , -C(=O)OR b , -OC(=O)OR b , -C(=O)NR c R d , -OC(=O)NR c R d , -NR b C(=O)NR c R d , -NR b C(=O)R a , -NR b C(=O)OR b , C 1- C6 alkyl, C 1- C6 haloalkyl, C 1- C6 deuterated alkyl, C 1- C6 hydroxyalkyl, C 1- C6 amino alkyl, C 2- C6 alkenyl, C 2- C6 alkynyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; wherein each of the alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl independently represents one or more of oxo, deuterium, halogen, -CN, -OR b , -NR c R d , -C(=O)R a , -C(=O)OR b , -C(=O)NR c R d , C 1- C6 alkyl, or C 1- optionally substituted with C6 haloalkyl; or two R on the same carbon D together form oxo; R 7 is C 1- C6 alkyl, C 1- C6 haloalkyl, C 1- C6 deuterated alkyl, C 1- C6 hydroxyalkyl, C 1- C6 amino alkyl, C 2- C6 alkenyl, C 2-C alkynyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; wherein each of the alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl independently represents one or more of oxo, deuterium, halogen, —CN, —OH, —OMe, —NH, —C(═O)Me, —C(═O)OH, —C(═O)OMe, C 1- C6 alkyl, or C 1- optionally substituted with C6 haloalkyl; Each R 8 are independently hydrogen, CN, C 1- C6 alkyl, C 1- C6 haloalkyl, C 1- C6 deuterated alkyl, C 1- C6 hydroxyalkyl, C 1- C6 amino alkyl, C 2- C6 alkenyl, C 2- C alkynyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; wherein each of the alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl independently represents one or more of oxo, deuterium, halogen, —CN, —OH, —OMe, —NH, —C(═O)Me, —C(═O)OH, —C(═O)OMe, C 1- C6 alkyl, or C 1- optionally substituted with C6 haloalkyl; R 9 and R 10 are independently hydrogen, C 1- C6 alkyl, C 1- C6 haloalkyl, C 1- C6 deuterated alkyl, C 1- C6 hydroxyalkyl, C 1- C6 amino alkyl, C 2- C6 alkenyl, C 2-C alkynyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; wherein each of the alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl independently represents one or more of oxo, deuterium, halogen, —CN, —OH, —OMe, —NH, —C(═O)Me, —C(═O)OH, —C(═O)OMe, C 1- C6 alkyl, C 1- C6 deuterated alkyl, C 1- C6 haloalkyl, C 1- C6 hydroxyalkyl, C 1- optionally substituted with C6 hydroxydeuterated alkyl, cycloalkyl, or heterocycloalkyl; or R 9 and R 10 together with the nitrogen atom to which they are attached, one or more of oxo, deuterium, halogen, -CN, -OH, -OMe, -NH2, -C(=O)Me, -C(=O)OH, -C(=O)OMe, C 1- C6 alkyl, or C 1- forming a heterocycloalkyl optionally substituted with C6 haloalkyl; or R 8 and R 9 together with the atoms to which they are attached, one or more of oxo, deuterium, halogen, -CN, -OH, -OMe, -NH2, -C(=O)Me, -C(=O)OH, -C(=O)OMe, C 1- C6 alkyl, or C 1- forming a heterocycloalkyl optionally substituted with C6 haloalkyl; R 11 is C1-C6 alkyl, C1-C6 haloalkyl, C1-C6 deuterated alkyl, C1-C6 hydroxyalkyl, C1-C6 aminoalkyl, C2-C6 alkenyl, C2-C6 alkynyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; wherein each of alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl is independently selected from one or more R 11a optionally replaced by; Each R 11a are independently deuterium, halogen, -CN, -OR b , -SR b , -S(=O)R a , -S(=O)2R a , -NO2, -NR c R d , -NHS(=O)2R a , -S(=O)2NR c R d , -C(=O)R a , -OC(=O)R a , -C(=O)OR b , -OC(=O)OR b , -C(=O)NR c R d , -OC(=O)NR c R d , -NR b C(=O)NR c R d , -NR b C(=O)R a , -NR b C(=O)OR b , C 1- C6 alkyl, C 1- C6 haloalkyl, C 1- C6 deuterated alkyl, C 1- C6 hydroxyalkyl, C 1- C6 amino alkyl, C 2- C6 alkenyl, or C 2- C6 alkynyl; Each R a independently, C 1- C6 alkyl, C 1- C6 haloalkyl, C 1- C6 deuterated alkyl, C 1- C6 hydroxyalkyl, C 1- C6 amino alkyl, C 2- C6 alkenyl, C 2-C alkynyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; wherein each of the alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl independently represents one or more of oxo, deuterium, halogen, —CN, —OH, —OMe, —NH, —C(═O)Me, —C(═O)OH, —C(═O)OMe, C 1- C6 alkyl, or C 1- optionally substituted with C6 haloalkyl; Each R b are independently hydrogen, C 1- C6 alkyl, C 1- C6 haloalkyl, C 1- C6 deuterated alkyl, C 1- C6 hydroxyalkyl, C 1- C6 amino alkyl, C 2- C6 alkenyl, C 2- C alkynyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; wherein each of the alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl independently represents one or more of oxo, deuterium, halogen, —CN, —OH, —OMe, —NH, —C(═O)Me, —C(═O)OH, —C(═O)OMe, C 1- C6 alkyl, or C 1- optionally substituted with C6 haloalkyl; Each R c and R d are independently hydrogen, C 1- C6 alkyl, C 1- C6 haloalkyl, C 1- C6 deuterated alkyl, C 1- C6 hydroxyalkyl, C 1- C6 amino alkyl, C 2- C6 alkenyl, C 2-C alkynyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; wherein each of the alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl independently represents one or more of oxo, deuterium, halogen, —CN, —OH, —OMe, —NH, —C(═O)Me, —C(═O)OH, —C(═O)OMe, C 1- C6 alkyl, or C 1- optionally substituted with C6 haloalkyl; or R c and R d together with the nitrogen atom to which they are attached, one or more of oxo, deuterium, halogen, -CN, -OH, -OMe, -NH2, -C(=O)Me, -C(=O)OH, -C(=O)OMe, C 1- C6 alkyl, or C 1- forming a heterocycloalkyl optionally substituted with C6 haloalkyl;

[0262] Disclosed herein is a compound of formula (XII) below, or a pharmaceutically acceptable salt, stereoisomer, or solvate thereof: [ka] During the ceremony: Ring B is cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; R 16 is -C(=O)NR 1 R 2 , -C(=N-CN)NR 1 R 2 , -P(=O)R 1 R 2 , or -C(=O)R 11 and; R 1 and R 2 are independently hydrogen, C 1- C6 alkyl, C 1- C6 haloalkyl, C 1- C6 deuterated alkyl, C 1- C6 hydroxyalkyl, C 1-C6 amino alkyl, C 2- C6 alkenyl, or C 2- C6 alkynyl; R 3 is hydrogen, C 1- C6 alkyl, C 1- C6 haloalkyl, or C 1- C6 deuterated alkyl; R 4 is hydrogen, deuterium, halogen, -CN, -OR b , -SR b , -S(=O)R a , -S(=O)2R a , -NO2, -NR c R d , -NHS(=O)2R a , -S(=O)2NR c R d , -C(=O)R a , -OC(=O)R a , -C(=O)OR b , -OC(=O)OR b , -C(=O)NR c R d , -OC(=O)NR c R d , -NR b C(=O)NR c R d , -NR b C(=O)R a , -NR b C(=O)OR b , -P(=O)R b R b , C 1- C6 alkyl, C 1- C6 haloalkyl, C 1- C6 deuterated alkyl, C 1- C6 hydroxyalkyl, C 1- C6 amino alkyl, C 2- C6 alkenyl, or C 2- C6 alkynyl; or R 3 and R 4 together form an optionally substituted ring; L is a bond or -C(=O)-; Ring A is a cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; each of which is selected from the group consisting of one or more R A optionally replaced by; Each R A are independently deuterium, halogen, -CN, -OR b , -SR b , -S(=O)R a , -S(=O)2R a , -NO2, -NR c R d , -NHS(=O)2R a , -S(=O)2NR c R d , -C(=O)R a , -OC(=O)R a , -C(=O)OR b , -OC(=O)OR b , -C(=O)NR c R d , -OC(=O)NR c R d , -NR b C(=O)NR c R d , -NR b C(=O)R a , -NR b C(=O)OR b , C 1- C6 alkyl, C 1- C6 haloalkyl, C 1- C6 deuterated alkyl, C 1- C6 hydroxyalkyl, C 1- C6 amino alkyl, C 2- C6 alkenyl, C 2- C6 alkynyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; wherein each of the alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl independently represents one or more of oxo, deuterium, halogen, -CN, -OR b , -NR c R d , -C(=O)R a , -C(=O)OR b , -C(=O)NRc R d , C 1- C6 alkyl, or C 1- optionally substituted with C6 haloalkyl; or two R on the same carbon A together form oxo; or -L-ring A is absent; Each X is independently -CR x -or-N-; Each R X are independently hydrogen, deuterium, halogen, -CN, -OR b , -SR b , -S(=O)R a , -S(=O)2R a , -NO2, -NR c R d , -NHS(=O)2R a , -S(=O)2NR c R d , -C(=O)R a , -OC(=O)R a , -C(=O)OR b , -OC(=O)OR b , -C(=O)NR c R d , -OC(=O)NR c R d , -NR b C(=O)NR c R d , -NR b C(=O)R a , -NR b C(=O)OR b , C 1- C6 alkyl, C 1- C6 haloalkyl, C 1- C6 deuterated alkyl, C 1- C6 hydroxyalkyl, C 1- C6 amino alkyl, C 2- C6 alkenyl, or C 2- C6 alkynyl; R 5 is halogen, -CN, -OR 8 , -SR 8 , -S(=O)R 7, -S(=O)2R 7 , -NO2, -NR 9 R 10 , -NR 8 S(=O)R 7 , -NR 8 S(=O)2R 7 , -S(=O)2NR 9 R 10 , -C(=N-CN)R 7 ,-C(=O)R 7 , -OC(=N-CN)R 7 , -OC(=O)R 7 , -C(=N-CN)OR 8 , -C(=O)OR 8 , -OC(=N-CN)OR 8 , -OC(=O)OR 8 , -C(=N-CN)NR 9 R 10 , -C(=O)NR 9 R 10 , -OC(=N-CN)NR 9 R 10 , -OC(=O)NR 9 R 10 , -NR 8 C(=N-CN)NR 9 R 10 , -NR 8 C(=O)NR 9 R 10 , -NR 8 C(=N-CN)R 7 , -NR 8 C(=N-OH)R 7 , -NR 8 C(=N-CN)OR 8 , -NR 8 C(=O)OR 8 , -NR 8 S(=O)(=NR 8 )R 7 , C 1- C6 alkyl, C 1- C6 haloalkyl, C 1- C6 deuterated alkyl, C 1- C6 hydroxyalkyl, C 1- C6 amino alkyl, C 2- C6 alkenyl, C 2-C6 alkynyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; wherein each of the alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl independently represents one or more of oxo, deuterium, halogen, -CN, -OR b , -NR c R d , -C(=O)R a , -C(=O)OR b , -C(=O)NR c R d , C 1- C6 alkyl, C 1- C6 haloalkyl, C 1- C6 deuterated alkyl, C 1- C6 hydroxyalkyl, C 1- C6 amino alkyl, C 1- C6 heteroalkyl, C 2- C6 alkenyl, C 2- C6 alkynyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, C 1- C6 alkyl (cycloalkyl), C 1- C6 alkyl (heterocycloalkyl), C 1- C6 alkyl (aryl), or C 1- and optionally substituted with C alkyl (heteroaryl); in which case each of alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl independently may be one or more of oxo, deuterium, halogen, -CN, -OR b , -NR c R d , -C(=O)R a , -C(=O)OR b , -C(=O)NR c R d , C 1- C6 alkyl, or C 1- optionally substituted with C6 haloalkyl; R 7 is C 1- C6 alkyl, C 1- C6 haloalkyl, C 1- C6 deuterated alkyl, C1- C6 hydroxyalkyl, C 1- C6 amino alkyl, C 2- C6 alkenyl, C 2- C alkynyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; wherein each of the alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl independently represents one or more of oxo, deuterium, halogen, —CN, —OH, —OMe, —NH, —C(═O)Me, —C(═O)OH, —C(═O)OMe, C 1- C6 alkyl, or C 1- optionally substituted with C6 haloalkyl; Each R 8 are independently hydrogen, CN, C 1- C6 alkyl, C 1- C6 haloalkyl, C 1- C6 deuterated alkyl, C 1- C6 hydroxyalkyl, C 1- C6 amino alkyl, C 2- C6 alkenyl, C 2- C alkynyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; wherein each of the alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl independently represents one or more of oxo, deuterium, halogen, —CN, —OH, —OMe, —NH, —C(═O)Me, —C(═O)OH, —C(═O)OMe, C 1- C6 alkyl, or C 1- optionally substituted with C6 haloalkyl; R 9 and R 10 are independently hydrogen, C 1- C6 alkyl, C 1- C6 haloalkyl, C 1- C6 deuterated alkyl, C 1- C6 hydroxyalkyl, C 1- C6 amino alkyl, C 2- C6 alkenyl, C 2-C alkynyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; wherein each of the alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl independently represents one or more of oxo, deuterium, halogen, —CN, —OH, —OMe, —NH, —C(═O)Me, —C(═O)OH, —C(═O)OMe, C 1- C6 alkyl, C 1- C6 deuterated alkyl, C 1- C6 haloalkyl, C 1- C6 hydroxyalkyl, C 1- optionally substituted with C6 hydroxydeuterated alkyl, cycloalkyl, or heterocycloalkyl; or R 9 and R 10 together with the nitrogen atom to which they are attached, one or more of oxo, deuterium, halogen, -CN, -OH, -OMe, -NH2, -C(=O)Me, -C(=O)OH, -C(=O)OMe, C 1- C6 alkyl, or C 1- forming a heterocycloalkyl optionally substituted with C6 haloalkyl; or R 8 and R 9 together with the atoms to which they are attached, one or more of oxo, deuterium, halogen, -CN, -OH, -OMe, -NH2, -C(=O)Me, -C(=O)OH, -C(=O)OMe, C 1- C6 alkyl, or C 1- forming a heterocycloalkyl optionally substituted with C6 haloalkyl; R 11 is C1-C6 alkyl, C1-C6 haloalkyl, C1-C6 deuterated alkyl, C1-C6 hydroxyalkyl, C1-C6 aminoalkyl, C2-C6 alkenyl, C2-C6 alkynyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; wherein each of alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl is independently selected from one or more R 11a optionally replaced by; Each R 11a are independently deuterium, halogen, -CN, -OR b , -SR b , -S(=O)R a , -S(=O)2R a , -NO2, -NR c R d , -NHS(=O)2R a , -S(=O)2NR c R d , -C(=O)R a , -OC(=O)R a , -C(=O)OR b , -OC(=O)OR b , -C(=O)NR c R d , -OC(=O)NR c R d , -NR b C(=O)NR c R d , -NR b C(=O)R a , -NR b C(=O)OR b , C 1- C6 alkyl, C 1- C6 haloalkyl, C 1- C6 deuterated alkyl, C 1- C6 hydroxyalkyl, C 1- C6 amino alkyl, C 2- C6 alkenyl, or C 2- C6 alkynyl; Each R a independently, C 1- C6 alkyl, C 1- C6 haloalkyl, C 1- C6 deuterated alkyl, C 1- C6 hydroxyalkyl, C 1- C6 amino alkyl, C 2- C6 alkenyl, C 2-C alkynyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; wherein each of the alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl independently represents one or more of oxo, deuterium, halogen, —CN, —OH, —OMe, —NH, —C(═O)Me, —C(═O)OH, —C(═O)OMe, C 1- C6 alkyl, or C 1- optionally substituted with C6 haloalkyl; Each R b are independently hydrogen, C 1- C6 alkyl, C 1- C6 haloalkyl, C 1- C6 deuterated alkyl, C 1- C6 hydroxyalkyl, C 1- C6 amino alkyl, C 2- C6 alkenyl, C 2- C alkynyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; wherein each of the alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl independently represents one or more of oxo, deuterium, halogen, —CN, —OH, —OMe, —NH, —C(═O)Me, —C(═O)OH, —C(═O)OMe, C 1- C6 alkyl, or C 1- optionally substituted with C6 haloalkyl; Each R c and R d are independently hydrogen, C 1- C6 alkyl, C 1- C6 haloalkyl, C 1- C6 deuterated alkyl, C 1- C6 hydroxyalkyl, C 1- C6 amino alkyl, C 2- C6 alkenyl, C 2-C alkynyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; wherein each of the alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl independently represents one or more of oxo, deuterium, halogen, —CN, —OH, —OMe, —NH, —C(═O)Me, —C(═O)OH, —C(═O)OMe, C 1- C6 alkyl, or C 1- optionally substituted with C6 haloalkyl; or R c and R d together with the nitrogen atom to which they are attached, one or more of oxo, deuterium, halogen, -CN, -OH, -OMe, -NH2, -C(=O)Me, -C(=O)OH, -C(=O)OMe, C 1- C6 alkyl, or C 1- forming a heterocycloalkyl optionally substituted with C6 haloalkyl;

[0263] Disclosed herein is a compound of formula (XII) below, or a pharmaceutically acceptable salt, solvate, or stereoisomer thereof: [ka] During the ceremony: Ring B is cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; R 16 is -C(=O)NR 1 R 2 , -C(=N-CN)NR 1 R 2 , -P(=O)R 1 R 2 , or -C(=O)R 11 and; R 1 and R 2 are independently hydrogen, C 1- C6 alkyl, C 1- C6 haloalkyl, C 1- C6 deuterated alkyl, C 1- C6 hydroxyalkyl, C 1-C6 amino alkyl, C 2- C6 alkenyl, or C 2- C6 alkynyl; R 3 is hydrogen, C 1- C6 alkyl, C 1- C6 haloalkyl, or C 1- C6 deuterated alkyl; R 4 is hydrogen, deuterium, halogen, -CN, -OR b , -SR b , -S(=O)R a , -S(=O)2R a , -NO2, -NR c R d , -NHS(=O)2R a , -S(=O)2NR c R d , -C(=O)R a , -OC(=O)R a , -C(=O)OR b , -OC(=O)OR b , -C(=O)NR c R d , -OC(=O)NR c R d , -NR b C(=O)NR c R d , -NR b C(=O)R a , -NR b C(=O)OR b , -P(=O)R b R b , C 1- C6 alkyl, C 1- C6 haloalkyl, C 1- C6 deuterated alkyl, C 1- C6 hydroxyalkyl, C 1- C6 amino alkyl, C 2- C6 alkenyl, or C 2- C6 alkynyl; or R 3 and R 4 together form an optionally substituted ring; L is a bond or -C(=O)-; Ring A is a cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; each of which is selected from the group consisting of one or more R A optionally replaced by; Each R A are independently deuterium, halogen, -CN, -OR b , -SR b , -S(=O)R a , -S(=O)2R a , -NO2, -NR c R d , -NHS(=O)2R a , -S(=O)2NR c R d , -C(=O)R a , -OC(=O)R a , -C(=O)OR b , -OC(=O)OR b , -C(=O)NR c R d , -OC(=O)NR c R d , -NR b C(=O)NR c R d , -NR b C(=O)R a , -NR b C(=O)OR b , C 1- C6 alkyl, C 1- C6 haloalkyl, C 1- C6 deuterated alkyl, C 1- C6 hydroxyalkyl, C 1- C6 amino alkyl, C 2- C6 alkenyl, C 2- C6 alkynyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; wherein each of the alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl independently represents one or more of oxo, deuterium, halogen, -CN, -OR b , -NR c R d , -C(=O)R a , -C(=O)OR b , -C(=O)NRc R d , C 1- C6 alkyl, or C 1- optionally substituted with C6 haloalkyl; or two R on the same carbon A together form oxo; Each X is independently -CR x -or-N-; Each R X are independently hydrogen, deuterium, halogen, -CN, -OR b , -SR b , -S(=O)R a , -S(=O)2R a , -NO2, -NR c R d , -NHS(=O)2R a , -S(=O)2NR c R d , -C(=O)R a , -OC(=O)R a , -C(=O)OR b , -OC(=O)OR b , -C(=O)NR c R d , -OC(=O)NR c R d , -NR b C(=O)NR c R d , -NR b C(=O)R a , -NR b C(=O)OR b , C 1- C6 alkyl, C 1- C6 haloalkyl, C 1- C6 deuterated alkyl, C 1- C6 hydroxyalkyl, C 1- C6 amino alkyl, C 2- C6 alkenyl, or C 2- C6 alkynyl; R 5 is halogen, -CN, -OR 8 , -SR 8 , -S(=O)R 7 , -S(=O)2R 7, -NO2, -NR 9 R 10 , -NR 8 S(=O)R 7 , -NR 8 S(=O)2R 7 , -S(=O)2NR 9 R 10 , -C(=N-CN)R 7 ,-C(=O)R 7 , -OC(=N-CN)R 7 , -OC(=O)R 7 , -C(=N-CN)OR 8 , -C(=O)OR 8 , -OC(=N-CN)OR 8 , -OC(=O)OR 8 , -C(=N-CN)NR 9 R 10 , -C(=O)NR 9 R 10 , -OC(=N-CN)NR 9 R 10 , -OC(=O)NR 9 R 10 , -NR 8 C(=N-CN)NR 9 R 10 , -NR 8 C(=O)NR 9 R 10 , -NR 8 C(=N-CN)R 7 , -NR 8 C(=N-OH)R 7 , -NR 8 C(=O)R 7 , -NR 8 C(=N-CN)OR 8 , -NR 8 C(=O)OR 8 , -NR 8 S(=O)(=NR 8 )R 7 , C 1- C6 alkyl, C 1- C6 haloalkyl, C 1- C6 deuterated alkyl, C 1- C6 hydroxyalkyl, C 1- C6 amino alkyl, C 2-C6 alkenyl, C 2- C6 alkynyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; wherein each of the alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl independently represents one or more of oxo, deuterium, halogen, -CN, -OR b , -NR c R d , -C(=O)R a , -C(=O)OR b , -C(=O)NR c R d , C 1- C6 alkyl, C 1- C6 haloalkyl, C 1- C6 deuterated alkyl, C 1- C6 hydroxyalkyl, C 1- C6 amino alkyl, C 1- C6 heteroalkyl, C 2- C6 alkenyl, C 2- C6 alkynyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, C 1- C6 alkyl (cycloalkyl), C 1- C6 alkyl (heterocycloalkyl), C 1- C6 alkyl (aryl), or C 1- and optionally substituted with C alkyl (heteroaryl); in which case each of alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl independently may be one or more of oxo, deuterium, halogen, -CN, -OR b , -NR c R d , -C(=O)R a , -C(=O)OR b , -C(=O)NR c R d , C 1- C6 alkyl, or C 1- optionally substituted with C6 haloalkyl; or R X and R 5 together with one or more R Dforming a ring D optionally substituted with; Ring D is cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; Each R D are independently hydrogen, deuterium, halogen, -CN, -OR b , -SR b , -S(=O)R a , -S(=O)2R a , -NO2, -NR c R d , -NHS(=O)2R a , -S(=O)2NR c R d , -C(=O)R a , -OC(=O)R a , -C(=O)OR b , -OC(=O)OR b , -C(=O)NR c R d , -OC(=O)NR c R d , -NR b C(=O)NR c R d , -NR b C(=O)R a , -NR b C(=O)OR b , C 1- C6 alkyl, C 1- C6 haloalkyl, C 1- C6 deuterated alkyl, C 1- C6 hydroxyalkyl, C 1- C6 amino alkyl, C 2- C6 alkenyl, C 2- C6 alkynyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; wherein each of the alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl independently represents one or more of oxo, deuterium, halogen, -CN, -OR b , -NR c R d , -C(=O)R a , -C(=O)OR b , -C(=O)NRc R d , C 1- C6 alkyl, or C 1- optionally substituted with C6 haloalkyl; or two R on the same carbon D together form oxo; R 7 is C 1- C6 alkyl, C 1- C6 haloalkyl, C 1- C6 deuterated alkyl, C 1- C6 hydroxyalkyl, C 1- C6 amino alkyl, C 2- C6 alkenyl, C 2- C alkynyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; wherein each of the alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl independently represents one or more of oxo, deuterium, halogen, —CN, —OH, —OMe, —NH, —C(═O)Me, —C(═O)OH, —C(═O)OMe, C 1- C6 alkyl, or C 1- optionally substituted with C6 haloalkyl; Each R 8 are independently hydrogen, CN, C 1- C6 alkyl, C 1- C6 haloalkyl, C 1- C6 deuterated alkyl, C 1- C6 hydroxyalkyl, C 1- C6 amino alkyl, C 2- C6 alkenyl, C 2- C alkynyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; wherein each of the alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl independently represents one or more of oxo, deuterium, halogen, —CN, —OH, —OMe, —NH, —C(═O)Me, —C(═O)OH, —C(═O)OMe, C 1- C6 alkyl, or C 1- optionally substituted with C6 haloalkyl; R 9 and R 10 are independently hydrogen, C 1- C6 alkyl, C 1- C6 haloalkyl, C 1- C6 deuterated alkyl, C 1- C6 hydroxyalkyl, C 1- C6 amino alkyl, C 2- C6 alkenyl, C 2- C alkynyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; wherein each of the alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl independently represents one or more of oxo, deuterium, halogen, —CN, —OH, —OMe, —NH, —C(═O)Me, —C(═O)OH, —C(═O)OMe, C 1- C6 alkyl, C 1- C6 deuterated alkyl, C 1- C6 haloalkyl, C 1- C6 hydroxyalkyl, C 1- optionally substituted with C6 hydroxydeuterated alkyl, cycloalkyl, or heterocycloalkyl; or R 9 and R 10 together with the nitrogen atom to which they are attached, one or more of oxo, deuterium, halogen, -CN, -OH, -OMe, -NH2, -C(=O)Me, -C(=O)OH, -C(=O)OMe, C 1- C6 alkyl, or C 1- forming a heterocycloalkyl optionally substituted with C6 haloalkyl; or R 8 and R 9 together with the atoms to which they are attached, one or more of oxo, deuterium, halogen, -CN, -OH, -OMe, -NH2, -C(=O)Me, -C(=O)OH, -C(=O)OMe, C 1- C6 alkyl, or C 1- forming a heterocycloalkyl optionally substituted with C6 haloalkyl; R 11is C1-C6 alkyl, C1-C6 haloalkyl, C1-C6 deuterated alkyl, C1-C6 hydroxyalkyl, C1-C6 aminoalkyl, C2-C6 alkenyl, C2-C6 alkynyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; wherein each of alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl is independently selected from one or more R 11a optionally replaced by; Each R 11a are independently deuterium, halogen, -CN, -OR b , -SR b , -S(=O)R a , -S(=O)2R a , -NO2, -NR c R d , -NHS(=O)2R a , -S(=O)2NR c R d , -C(=O)R a , -OC(=O)R a , -C(=O)OR b , -OC(=O)OR b , -C(=O)NR c R d , -OC(=O)NR c R d , -NR b C(=O)NR c R d , -NR b C(=O)R a , -NR b C(=O)OR b , C 1- C6 alkyl, C 1- C6 haloalkyl, C 1- C6 deuterated alkyl, C 1- C6 hydroxyalkyl, C 1- C6 amino alkyl, C 2- C6 alkenyl, or C 2- C6 alkynyl; Each R a independently, C 1- C6 alkyl, C 1- C6 haloalkyl, C1- C6 deuterated alkyl, C 1- C6 hydroxyalkyl, C 1- C6 amino alkyl, C 2- C6 alkenyl, C 2- C alkynyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; wherein each of the alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl independently represents one or more of oxo, deuterium, halogen, —CN, —OH, —OMe, —NH, —C(═O)Me, —C(═O)OH, —C(═O)OMe, C 1- C6 alkyl, or C 1- optionally substituted with C6 haloalkyl; Each R b are independently hydrogen, C 1- C6 alkyl, C 1- C6 haloalkyl, C 1- C6 deuterated alkyl, C 1- C6 hydroxyalkyl, C 1- C6 amino alkyl, C 2- C6 alkenyl, C 2- C alkynyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; wherein each of the alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl independently represents one or more of oxo, deuterium, halogen, —CN, —OH, —OMe, —NH, —C(═O)Me, —C(═O)OH, —C(═O)OMe, C 1- C6 alkyl, or C 1- optionally substituted with C6 haloalkyl; Each R c and R d are independently hydrogen, C 1- C6 alkyl, C 1- C6 haloalkyl, C 1- C6 deuterated alkyl, C 1- C6 hydroxyalkyl, C 1- C6 amino alkyl, C 2- C6 alkenyl, C 2-C alkynyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; wherein each of the alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl independently represents one or more of oxo, deuterium, halogen, —CN, —OH, —OMe, —NH, —C(═O)Me, —C(═O)OH, —C(═O)OMe, C 1- C6 alkyl, or C 1- optionally substituted with C6 haloalkyl; or R c and R d together with the nitrogen atom to which they are attached, one or more of oxo, deuterium, halogen, -CN, -OH, -OMe, -NH2, -C(=O)Me, -C(=O)OH, -C(=O)OMe, C 1- C6 alkyl, or C 1- forming a heterocycloalkyl optionally substituted with C6 haloalkyl;

[0264] Disclosed herein is a compound of formula (XII) below, or a pharmaceutically acceptable salt, solvate, or stereoisomer thereof: [ka] During the ceremony: Ring B is cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; R 16 is -C(=O)NR 1 R 2 , -C(=N-CN)NR 1 R 2 , -P(=O)R 1 R 2 , or -C(=O)R 11 and; R 1 and R 2 are independently hydrogen, C 1- C6 alkyl, C 1- C6 haloalkyl, C 1- C6 deuterated alkyl, C 1- C6 hydroxyalkyl, C 1-C6 amino alkyl, C 2- C6 alkenyl, or C 2- C6 alkynyl; R 3 is hydrogen, C 1- C6 alkyl, C 1- C6 haloalkyl, or C 1- C6 deuterated alkyl; R 4 is hydrogen, deuterium, halogen, -CN, -OR b , -SR b , -S(=O)R a , -S(=O)2R a , -NO2, -NR c R d , -NHS(=O)2R a , -S(=O)2NR c R d , -C(=O)R a , -OC(=O)R a , -C(=O)OR b , -OC(=O)OR b , -C(=O)NR c R d , -OC(=O)NR c R d , -NR b C(=O)NR c R d , -NR b C(=O)R a , -NR b C(=O)OR b , -P(=O)R b R b , C 1- C6 alkyl, C 1- C6 haloalkyl, C 1- C6 deuterated alkyl, C 1- C6 hydroxyalkyl, C 1- C6 amino alkyl, C 2- C6 alkenyl, or C 2- C6 alkynyl; or R 3 and R 4 together form an optionally substituted ring; Each X is independently -CR x-or-N-; Each R X are independently hydrogen, deuterium, halogen, -CN, -OR b , -SR b , -S(=O)R a , -S(=O)2R a , -NO2, -NR c R d , -NHS(=O)2R a , -S(=O)2NR c R d , -C(=O)R a , -OC(=O)R a , -C(=O)OR b , -OC(=O)OR b , -C(=O)NR c R d , -OC(=O)NR c R d , -NR b C(=O)NR c R d , -NR b C(=O)R a , -NR b C(=O)OR b , C 1- C6 alkyl, C 1- C6 haloalkyl, C 1- C6 deuterated alkyl, C 1- C6 hydroxyalkyl, C 1- C6 amino alkyl, C 2- C6 alkenyl, or C 2- C6 alkynyl; R 5 is a halogen, -CN, -OR 8 , -SR 8 , -S(=O)R 7 , -S(=O)2R 7 , -NO2, -NR 9 R 10 , -NR 8 S(=O)R 7 , -NR 8 S(=O)2R 7 , -S(=O)2NR 9 R 10 , -C(=N-CN)R 7,-C(=O)R 7 , -OC(=N-CN)R 7 , -OC(=O)R 7 , -C(=N-CN)OR 8 , -C(=O)OR 8 , -OC(=N-CN)OR 8 , -OC(=O)OR 8 , -C(=N-CN)NR 9 R 10 , -C(=O)NR 9 R 10 , -OC(=N-CN)NR 9 R 10 , -OC(=O)NR 9 R 10 , -NR 8 C(=N-CN)NR 9 R 10 , -NR 8 C(=O)NR 9 R 10 , -NR 8 C(=N-CN)R 7 , -NR 8 C(=N-OH)R 7 , -NR 8 C(=O)R 7 , -NR 8 C(=N-CN)OR 8 , -NR 8 C(=O)OR 8 , -NR 8 S(=O)(=NR 8 )R 7 , C 1- C6 alkyl, C 1- C6 haloalkyl, C 1- C6 deuterated alkyl, C 1- C6 hydroxyalkyl, C 1- C6 amino alkyl, C 2- C6 alkenyl, C 2- C6 alkynyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; wherein each of the alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl independently represents one or more of oxo, deuterium, halogen, -CN, -OR b , -NRc R d , -C(=O)R a , -C(=O)OR b , -C(=O)NR c R d , C 1- C6 alkyl, C 1- C6 haloalkyl, C 1- C6 deuterated alkyl, C 1- C6 hydroxyalkyl, C 1- C6 amino alkyl, C 1- C6 heteroalkyl, C 2- C6 alkenyl, C 2- C6 alkynyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, C 1- C6 alkyl (cycloalkyl), C 1- C6 alkyl (heterocycloalkyl), C 1- C6 alkyl (aryl), or C 1- and optionally substituted with C alkyl (heteroaryl); in which case each of alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl independently may be one or more of oxo, deuterium, halogen, -CN, -OR b , -NR c R d , -C(=O)R a , -C(=O)OR b , -C(=O)NR c R d , C 1- C6 alkyl, or C 1- optionally substituted with C6 haloalkyl; or R X and R 5 together with one or more R D forming a ring D optionally substituted with; Ring D is cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; Each R D are independently hydrogen, deuterium, halogen, -CN, -OR b , -SR b , -S(=O)R a , -S(=O)2Ra , -NO2, -NR c R d , -NHS(=O)2R a , -S(=O)2NR c R d , -C(=O)R a , -OC(=O)R a , -C(=O)OR b , -OC(=O)OR b , -C(=O)NR c R d , -OC(=O)NR c R d , -NR b C(=O)NR c R d , -NR b C(=O)R a , -NR b C(=O)OR b , C 1- C6 alkyl, C 1- C6 haloalkyl, C 1- C6 deuterated alkyl, C 1- C6 hydroxyalkyl, C 1- C6 amino alkyl, C 2- C6 alkenyl, C 2- C6 alkynyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; wherein each of the alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl independently represents one or more of oxo, deuterium, halogen, -CN, -OR b , -NR c R d , -C(=O)R a , -C(=O)OR b , -C(=O)NR c R d , C 1- C6 alkyl, or C 1- optionally substituted with C6 haloalkyl; or two R on the same carbon D together form oxo; R 7 is C 1- C6 alkyl, C 1-C6 haloalkyl, C 1- C6 deuterated alkyl, C 1- C6 hydroxyalkyl, C 1- C6 amino alkyl, C 2- C6 alkenyl, C 2- C alkynyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; wherein each of the alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl independently represents one or more of oxo, deuterium, halogen, —CN, —OH, —OMe, —NH, —C(═O)Me, —C(═O)OH, —C(═O)OMe, C 1- C6 alkyl, or C 1- optionally substituted with C6 haloalkyl; Each R 8 are independently hydrogen, CN, C 1- C6 alkyl, C 1- C6 haloalkyl, C 1- C6 deuterated alkyl, C 1- C6 hydroxyalkyl, C 1- C6 amino alkyl, C 2- C6 alkenyl, C 2- C alkynyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; wherein each of the alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl independently represents one or more of oxo, deuterium, halogen, —CN, —OH, —OMe, —NH, —C(═O)Me, —C(═O)OH, —C(═O)OMe, C 1- C6 alkyl, or C 1- optionally substituted with C6 haloalkyl; R 9 and R 10 are independently hydrogen, C 1- C6 alkyl, C 1- C6 haloalkyl, C 1- C6 deuterated alkyl, C 1- C6 hydroxyalkyl, C 1- C6 amino alkyl, C 2- C6 alkenyl, C 2-C alkynyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; wherein each of the alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl independently represents one or more of oxo, deuterium, halogen, —CN, —OH, —OMe, —NH, —C(═O)Me, —C(═O)OH, —C(═O)OMe, C 1- C6 alkyl, C 1- C6 deuterated alkyl, C 1- C6 haloalkyl, C 1- C6 hydroxyalkyl, C 1- optionally substituted with C6 hydroxydeuterated alkyl, cycloalkyl, or heterocycloalkyl; or R 9 and R 10 together with the nitrogen atom to which they are attached, one or more of oxo, deuterium, halogen, -CN, -OH, -OMe, -NH2, -C(=O)Me, -C(=O)OH, -C(=O)OMe, C 1- C6 alkyl, or C 1- forming a heterocycloalkyl optionally substituted with C6 haloalkyl; or R 8 and R 9 together with the atoms to which they are attached, one or more of oxo, deuterium, halogen, -CN, -OH, -OMe, -NH2, -C(=O)Me, -C(=O)OH, -C(=O)OMe, C 1- C6 alkyl, or C 1- forming a heterocycloalkyl optionally substituted with C6 haloalkyl; R 11 is C1-C6 alkyl, C1-C6 haloalkyl, C1-C6 deuterated alkyl, C1-C6 hydroxyalkyl, C1-C6 aminoalkyl, C2-C6 alkenyl, C2-C6 alkynyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; wherein each of alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl is independently selected from one or more R 11a optionally replaced by; Each R 11a are independently deuterium, halogen, -CN, -OR b , -SR b , -S(=O)R a , -S(=O)2R a , -NO2, -NR c R d , -NHS(=O)2R a , -S(=O)2NR c R d , -C(=O)R a , -OC(=O)R a , -C(=O)OR b , -OC(=O)OR b , -C(=O)NR c R d , -OC(=O)NR c R d , -NR b C(=O)NR c R d , -NR b C(=O)R a , -NR b C(=O)OR b , C 1- C6 alkyl, C 1- C6 haloalkyl, C 1- C6 deuterated alkyl, C 1- C6 hydroxyalkyl, C 1- C6 amino alkyl, C 2- C6 alkenyl, or C 2- C6 alkynyl; Each R a independently, C 1- C6 alkyl, C 1- C6 haloalkyl, C 1- C6 deuterated alkyl, C 1- C6 hydroxyalkyl, C 1- C6 amino alkyl, C 2- C6 alkenyl, C 2-C alkynyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; wherein each of the alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl independently represents one or more of oxo, deuterium, halogen, —CN, —OH, —OMe, —NH, —C(═O)Me, —C(═O)OH, —C(═O)OMe, C 1- C6 alkyl, or C 1- optionally substituted with C6 haloalkyl; Each R b are independently hydrogen, C 1- C6 alkyl, C 1- C6 haloalkyl, C 1- C6 deuterated alkyl, C 1- C6 hydroxyalkyl, C 1- C6 amino alkyl, C 2- C6 alkenyl, C 2- C alkynyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; wherein each of the alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl independently represents one or more of oxo, deuterium, halogen, —CN, —OH, —OMe, —NH, —C(═O)Me, —C(═O)OH, —C(═O)OMe, C 1- C6 alkyl, or C 1- optionally substituted with C6 haloalkyl; Each R c and R d are independently hydrogen, C 1- C6 alkyl, C 1- C6 haloalkyl, C 1- C6 deuterated alkyl, C 1- C6 hydroxyalkyl, C 1- C6 amino alkyl, C 2- C6 alkenyl, C 2-C alkynyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; wherein each of the alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl independently represents one or more of oxo, deuterium, halogen, —CN, —OH, —OMe, —NH, —C(═O)Me, —C(═O)OH, —C(═O)OMe, C 1- C6 alkyl, or C 1- optionally substituted with C6 haloalkyl; or R c and R d together with the nitrogen atom to which they are attached, one or more of oxo, deuterium, halogen, -CN, -OH, -OMe, -NH2, -C(=O)Me, -C(=O)OH, -C(=O)OMe, C 1- C6 alkyl, or C 1- forming a heterocycloalkyl optionally substituted with C6 haloalkyl;

[0265] In some embodiments of the compound of Formula (XII), ring B is aryl or heteroaryl. In some embodiments of the compound of Formula (XII), ring B is aryl. In some embodiments of the compound of Formula (XII), ring B is phenyl. In some embodiments of the compound of Formula (XII), ring B is heteroaryl. In some embodiments of the compound of Formula (XII), ring B is 5- or 6-membered heteroaryl. In some embodiments of the compound of Formula (XII), ring B is 6-membered heteroaryl. In some embodiments of the compound of Formula (XII), ring B is pyridyl.

[0266] Disclosed herein is a compound of formula (XII') below, or a pharmaceutically acceptable salt, solvate, or stereoisomer thereof: [ka] During the ceremony: R 16 is -C(=O)NR 1 R 2 , -C(=N-CN)NR1 R 2 , -P(=O)R 1 R 2 , or -C(=O)R 11 and; R 1 and R 2 are independently hydrogen, C 1- C6 alkyl, C 1- C6 haloalkyl, C 1- C6 deuterated alkyl, C 1- C6 hydroxyalkyl, C 1- C6 amino alkyl, C 2- C6 alkenyl, or C 2- C6 alkynyl; R 3 is hydrogen, C 1- C6 alkyl, C 1- C6 haloalkyl, or C 1- C6 deuterated alkyl; R 4 is hydrogen, deuterium, halogen, -CN, -OR b , -SR b , -S(=O)R a , -S(=O)2R a , -NO2, -NR c R d , -NHS(=O)2R a , -S(=O)2NR c R d , -C(=O)R a , -OC(=O)R a , -C(=O)OR b , -OC(=O)OR b , -C(=O)NR c R d , -OC(=O)NR c R d , -NR b C(=O)NR c R d , -NR b C(=O)R a , -NR b C(=O)OR b , -P(=O)R b R b , C 1- C6 alkyl, C1- C6 haloalkyl, C 1- C6 deuterated alkyl, C 1- C6 hydroxyalkyl, C 1- C6 amino alkyl, C 2- C6 alkenyl, or C 2- C6 alkynyl; or R 3 and R 4 together form an optionally substituted ring; L is a bond or -C(=O)-; Ring A is a cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; each of which is selected from the group consisting of one or more R A optionally replaced by; Each R A are independently deuterium, halogen, -CN, -OR b , -SR b , -S(=O)R a , -S(=O)2R a , -NO2, -NR c R d , -NHS(=O)2R a , -S(=O)2NR c R d , -C(=O)R a , -OC(=O)R a , -C(=O)OR b , -OC(=O)OR b , -C(=O)NR c R d , -OC(=O)NR c R d , -NR b C(=O)NR c R d , -NR b C(=O)R a , -NR b C(=O)OR b , C 1- C6 alkyl, C 1- C6 haloalkyl, C 1- C6 deuterated alkyl, C 1- C6 hydroxyalkyl, C 1- C6 amino alkyl, C 2- C6 alkenyl, C2- C6 alkynyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; wherein each of the alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl independently represents one or more of oxo, deuterium, halogen, -CN, -OR b , -NR c R d , -C(=O)R a , -C(=O)OR b , -C(=O)NR c R d , C 1- C6 alkyl, or C 1- optionally substituted with C6 haloalkyl; or two R on the same carbon A together form oxo; Each X is independently -CR x -or-N-; Each R X are independently hydrogen, deuterium, halogen, -CN, -OR b , -SR b , -S(=O)R a , -S(=O)2R a , -NO2, -NR c R d , -NHS(=O)2R a , -S(=O)2NR c R d , -C(=O)R a , -OC(=O)R a , -C(=O)OR b , -OC(=O)OR b , -C(=O)NR c R d , -OC(=O)NR c R d , -NR b C(=O)NR c R d , -NR b C(=O)R a , -NR b C(=O)OR b , C 1- C6 alkyl, C 1-C6 haloalkyl, C 1- C6 deuterated alkyl, C 1- C6 hydroxyalkyl, C 1- C6 amino alkyl, C 2- C6 alkenyl, or C 2- C6 alkynyl; R 5 is halogen, -CN, -OR 8 , -SR 8 , -S(=O)R 7 , -S(=O)2R 7 , -NO2, -NR 9 R 10 , -NR 8 S(=O)R 7 , -NR 8 S(=O)2R 7 , -S(=O)2NR 9 R 10 , -C(=N-CN)R 7 ,-C(=O)R 7 , -OC(=N-CN)R 7 , -OC(=O)R 7 , -C(=N-CN)OR 8 , -C(=O)OR 8 , -OC(=N-CN)OR 8 , -OC(=O)OR 8 , -C(=N-CN)NR 9 R 10 , -C(=O)NR 9 R 10 , -OC(=N-CN)NR 9 R 10 , -OC(=O)NR 9 R 10 , -NR 8 C(=N-CN)NR 9 R 10 , -NR 8 C(=O)NR 9 R 10 , -NR 8 C(=N-CN)R 7 , -NR 8 C(=N-OH)R 7 , -NR 8 C(=O)R 7 , -NR 8C(=N-CN)OR 8 , -NR 8 C(=O)OR 8 , -NR 8 S(=O)(=NR 8 )R 7 , C 1- C6 alkyl, C 1- C6 haloalkyl, C 1- C6 deuterated alkyl, C 1- C6 hydroxyalkyl, C 1- C6 amino alkyl, C 2- C6 alkenyl, C 2- C6 alkynyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; wherein each of the alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl independently represents one or more of oxo, deuterium, halogen, -CN, -OR b , -NR c R d , -C(=O)R a , -C(=O)OR b , -C(=O)NR c R d , C 1- C6 alkyl, C 1- C6 haloalkyl, C 1- C6 deuterated alkyl, C 1- C6 hydroxyalkyl, C 1- C6 amino alkyl, C 1- C6 heteroalkyl, C 2- C6 alkenyl, C 2- C6 alkynyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, C 1- C6 alkyl (cycloalkyl), C 1- C6 alkyl (heterocycloalkyl), C 1- C6 alkyl (aryl), or C 1- and optionally substituted with C alkyl (heteroaryl); in which case each of alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl independently may be one or more of oxo, deuterium, halogen, -CN, -OR b, -NR c R d , -C(=O)R a , -C(=O)OR b , -C(=O)NR c R d , C 1- C6 alkyl, or C 1- optionally substituted with C6 haloalkyl; or R X and R 5 together with one or more R D forming a ring D optionally substituted with; Ring D is cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; Each R D are independently hydrogen, deuterium, halogen, -CN, -OR b , -SR b , -S(=O)R a , -S(=O)2R a , -NO2, -NR c R d , -NHS(=O)2R a , -S(=O)2NR c R d , -C(=O)R a , -OC(=O)R a , -C(=O)OR b , -OC(=O)OR b , -C(=O)NR c R d , -OC(=O)NR c R d , -NR b C(=O)NR c R d , -NR b C(=O)R a , -NR b C(=O)OR b , C 1- C6 alkyl, C 1- C6 haloalkyl, C 1- C6 deuterated alkyl, C 1- C6 hydroxyalkyl, C 1- C6 amino alkyl, C 2- C6 alkenyl, C 2-C6 alkynyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; wherein each of the alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl independently represents one or more of oxo, deuterium, halogen, -CN, -OR b , -NR c R d , -C(=O)R a , -C(=O)OR b , -C(=O)NR c R d , C 1- C6 alkyl, or C 1- optionally substituted with C6 haloalkyl; or two R on the same carbon D together form oxo; R 7 is C 1- C6 alkyl, C 1- C6 haloalkyl, C 1- C6 deuterated alkyl, C 1- C6 hydroxyalkyl, C 1- C6 amino alkyl, C 2- C6 alkenyl, C 2- C alkynyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; wherein each of the alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl independently represents one or more of oxo, deuterium, halogen, —CN, —OH, —OMe, —NH, —C(═O)Me, —C(═O)OH, —C(═O)OMe, C 1- C6 alkyl, or C 1- optionally substituted with C6 haloalkyl; Each R 8 are independently hydrogen, CN, C 1- C6 alkyl, C 1- C6 haloalkyl, C 1- C6 deuterated alkyl, C 1- C6 hydroxyalkyl, C 1- C6 amino alkyl, C 2- C6 alkenyl, C 2-C alkynyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; wherein each of the alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl independently represents one or more of oxo, deuterium, halogen, —CN, —OH, —OMe, —NH, —C(═O)Me, —C(═O)OH, —C(═O)OMe, C 1- C6 alkyl, or C 1- optionally substituted with C6 haloalkyl; R 9 and R 10 are independently hydrogen, C 1- C6 alkyl, C 1- C6 haloalkyl, C 1- C6 deuterated alkyl, C 1- C6 hydroxyalkyl, C 1- C6 amino alkyl, C 2- C6 alkenyl, C 2- C alkynyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; wherein each of the alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl independently represents one or more of oxo, deuterium, halogen, —CN, —OH, —OMe, —NH, —C(═O)Me, —C(═O)OH, —C(═O)OMe, C 1- C6 alkyl, C 1- C6 deuterated alkyl, C 1- C6 haloalkyl, C 1- C6 hydroxyalkyl, C 1- optionally substituted with C6 hydroxydeuterated alkyl, cycloalkyl, or heterocycloalkyl; or R 9 and R 10 together with the nitrogen atom to which they are attached, one or more of oxo, deuterium, halogen, -CN, -OH, -OMe, -NH2, -C(=O)Me, -C(=O)OH, -C(=O)OMe, C 1- C6 alkyl, or C 1- forming a heterocycloalkyl optionally substituted with C6 haloalkyl; or R 8 and R 9 together with the atoms to which they are attached, one or more of oxo, deuterium, halogen, -CN, -OH, -OMe, -NH2, -C(=O)Me, -C(=O)OH, -C(=O)OMe, C 1- C6 alkyl, or C 1- forming a heterocycloalkyl optionally substituted with C6 haloalkyl; R 11 is C1-C6 alkyl, C1-C6 haloalkyl, C1-C6 deuterated alkyl, C1-C6 hydroxyalkyl, C1-C6 aminoalkyl, C2-C6 alkenyl, C2-C6 alkynyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; wherein each of alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl is independently selected from one or more R 11a optionally replaced by; Each R 11a are independently deuterium, halogen, -CN, -OR b , -SR b , -S(=O)R a , -S(=O)2R a , -NO2, -NR c R d , -NHS(=O)2R a , -S(=O)2NR c R d , -C(=O)R a , -OC(=O)R a , -C(=O)OR b , -OC(=O)OR b , -C(=O)NR c R d , -OC(=O)NR c R d , -NR b C(=O)NR c R d , -NR b C(=O)R a , -NR b C(=O)OR b , C 1- C6 alkyl, C1- C6 haloalkyl, C 1- C6 deuterated alkyl, C 1- C6 hydroxyalkyl, C 1- C6 amino alkyl, C 2- C6 alkenyl, or C 2- C6 alkynyl; Each R a independently, C 1- C6 alkyl, C 1- C6 haloalkyl, C 1- C6 deuterated alkyl, C 1- C6 hydroxyalkyl, C 1- C6 amino alkyl, C 2- C6 alkenyl, C 2- C alkynyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; wherein each of the alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl independently represents one or more of oxo, deuterium, halogen, —CN, —OH, —OMe, —NH, —C(═O)Me, —C(═O)OH, —C(═O)OMe, C 1- C6 alkyl, or C 1- optionally substituted with C6 haloalkyl; Each R b are independently hydrogen, C 1- C6 alkyl, C 1- C6 haloalkyl, C 1- C6 deuterated alkyl, C 1- C6 hydroxyalkyl, C 1- C6 amino alkyl, C 2- C6 alkenyl, C 2- C alkynyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; wherein each of the alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl independently represents one or more of oxo, deuterium, halogen, —CN, —OH, —OMe, —NH, —C(═O)Me, —C(═O)OH, —C(═O)OMe, C 1- C6 alkyl, or C 1-optionally substituted with C6 haloalkyl; Each R c and R d are independently hydrogen, C 1- C6 alkyl, C 1- C6 haloalkyl, C 1- C6 deuterated alkyl, C 1- C6 hydroxyalkyl, C 1- C6 amino alkyl, C 2- C6 alkenyl, C 2- C alkynyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; wherein each of the alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl independently represents one or more of oxo, deuterium, halogen, —CN, —OH, —OMe, —NH, —C(═O)Me, —C(═O)OH, —C(═O)OMe, C 1- C6 alkyl, or C 1- optionally substituted with C6 haloalkyl; or R c and R d together with the nitrogen atom to which they are attached, one or more of oxo, deuterium, halogen, -CN, -OH, -OMe, -NH2, -C(=O)Me, -C(=O)OH, -C(=O)OMe, C 1- C6 alkyl, or C 1- forming a heterocycloalkyl optionally substituted with C6 haloalkyl;

[0267] In some embodiments of the compound of Formula (XII) or (XII'), L is a bond. In some embodiments of the compound of Formula (XII) or (XII'), L is -C(=O)-.

[0268] In some embodiments of compounds of Formula (XII) or (XII'), the -L-ring A is absent.

[0269] In some embodiments of compounds of Formula (XII) or (XII'), ring A is heterocycloalkyl or heteroaryl; each of which contains one or more R AIn some embodiments of compounds of Formula (XII) or (XII'), ring A is a 5-membered heterocycloalkyl or a 5-membered heteroaryl; each optionally substituted with one or more R A In some embodiments of compounds of Formula (XII) or (XII'), ring A is optionally substituted with one or more R A is heteroaryl optionally substituted with

[0270] In some embodiments of compounds of Formula (XII) or (XII'), each R A are independently deuterium, halogen, -CN, -OR b , -NR c R d , -C(=O)R a , -C(=O)OR b , -C(=O)NR c R d , -OC(=O)NR c R d , C 1- C6 alkyl, C 1- C6 haloalkyl, or C 1- In some embodiments of compounds of Formula (XII) or (XII'), each R A is independently deuterium, halogen, C-C alkyl, C-C haloalkyl, or C-C deuterated alkyl. In some embodiments of compounds of Formula (XII) or (XII'), each R A is independently halogen or C1-C6 alkyl. In some embodiments of compounds of Formula (XII) or (XII'), each R A are independently C1-C6 alkyl.

[0271] In some embodiments of the compound of Formula (XII), the compound is a compound of Formula (XIIa): [ka]

[0272] In some embodiments of the compound of Formula (XII), the compound is a compound of Formula (XIIb): [ka]

[0273] In some embodiments of compounds of Formula (XII), (XII'), (XIIa), (XIIb), or (XIIc), R 4 is hydrogen, deuterium, halogen, -CN, -OR b , -NR c R d , -C(=O)R a , -C(=O)OR b , -C(=O)NR c R d , -OC(=O)NR c R d , C 1- C6 alkyl, C 1- C6 haloalkyl, or C 1- In some embodiments of compounds of Formula (XII), (XII'), (XIIa), (XIIb), or (XIIc), R 4 is hydrogen or -OR b In some embodiments of the compound of Formula (XII), (XII'), (XIIa), (XIIb), or (XIIc), R 4 -OR b In some embodiments of the compound of Formula (XII), (XII'), (XIIa), (XIIb), or (XIIc), R 4 is hydrogen. In some embodiments of the compound of Formula (XII), R 4 is -P(=O)R b R b In some embodiments of the compound of Formula (XII), (XII'), (XIIa), (XIIb), or (XIIc), R 4 is -S(=O)2R a is.

[0274] In some embodiments of the compound of Formula (XII), (XII'), (XIIa), (XIIb), or (XIIc), each X is -N-. In some embodiments of the compound of Formula (XII), (XII'), (XIIa), (XIIb), or (XIIc), each X is -CR X In some embodiments of compounds of Formula (XII), (XII'), (XIIa), (XIIb), or (XIIc), two X's are -N- and the other X's are -CR X In some embodiments of compounds of Formula (XII), (XII'), (XIIa), (XIIb), or (XIIc), one X is -N- and the other X is -CR X In some embodiments of a compound of Formula (XII), (XII'), (XIIa), (XIIb), or (XIIc), each X is -CH-. In some embodiments of a compound of Formula (XII), (XII'), (XIIa), (XIIb), or (XIIc), two X are -N- and the other X is -CH-. In some embodiments of a compound of Formula (XII), (XII'), (XIIa), (XIIb), or (XIIc), one X is -N- and the other X is -CH-. In some embodiments of a compound of Formula (XII), (XII'), (XIIa), (XIIb), or (XIIc), [ka] In some embodiments of the compound of Formula (XII), (XII'), (XIIa), (XIIb), or (XIIc), [ka] In some embodiments of the compound of Formula (XII), (XII'), (XIIa), (XIIb), or (XIIc), [ka] is.

[0275] In some embodiments of compounds of Formula (XII), (XII'), (XIIa), (XIIb), or (XIIc), each R X are independently hydrogen, deuterium, halogen, -CN, -OR b , -NR c R d , -C(=O)R a , -C(=O)OR b , C1-C6 alkyl, C1-C6 haloalkyl, C1-C6 deuterated alkyl, C1-C6 hydroxyalkyl, or C1-C6 aminoalkyl. In some embodiments of compounds of Formula (XII), (XII'), (XIIa), (XIIb), or (XIIc), each R X is independently hydrogen, deuterium, halogen, C-C alkyl, C-C haloalkyl, or C-C deuterated alkyl. In some embodiments of compounds of Formula (XII), (XII'), (XIIa), (XIIb), or (XIIc), each R X are independently hydrogen, deuterium, or halogen.

[0276] In some embodiments of the compound of Formula (XII), (XII'), (XIIa), (XIIb), or (XIIc), [ka] In some embodiments of the compound of Formula (XII), (XII'), (XIIa), (XIIb), or (XIIc), [ka] In some embodiments of the compound of Formula (XII), (XII'), (XIIa), (XIIb), or (XIIc), [ka] is.

[0277] In some embodiments of compounds of Formula (XII), (XII'), (XIIa), (XIIb), or (XIIc), R 3is hydrogen or C1-C6 alkyl. In some embodiments of compounds of Formula (XII), (XII'), (XIIa), (XIIb), or (XIIc), R 3 is hydrogen.

[0278] In some embodiments of compounds of Formula (XII), (XII'), (XIIa), (XIIb), or (XIIc), R 16 is C(=O)NR 1 R 2 or -C(=O)R 11 In some embodiments of the compound of Formula (XII), (XII'), (XIIa), (XIIb), or (XIIc), R 16 is -C(=O)NR 1 R 2 In some embodiments of the compound of Formula (XII), (XII'), (XIIa), (XIIb), or (XIIc), R 16 is -C(=N-CN)NR 1 R 2 In some embodiments of the compound of Formula (XII), (XII'), (XIIa), (XIIb), or (XIIc), R 16 is -P(=O)R 1 R 2 In some embodiments of the compound of Formula (XII), (XII'), (XIIa), (XIIb), or (XIIc), R 16 is -C(=O)R 11 is.

[0279] In some embodiments of compounds of Formula (XII), (XII'), (XIIa), (XIIb), or (XIIc), R 1 and R 2 is independently hydrogen, C-C alkyl, C-C haloalkyl, or C-C deuterated alkyl. In some embodiments of compounds of Formula (XII), (XII'), (XIIa), (XIIb), or (XIIc), R 1 and R 2is independently hydrogen, or C-C deuterated alkyl. In some embodiments of compounds of Formula (XII), (XII'), (XIIa), (XIIb), or (XIIc), R 1 and R 2 is independently C-C alkyl. In some embodiments of compounds of Formula (XII), (XII'), (XIIa), (XIIb), or (XIIc), R 1 is hydrogen. In some embodiments of compounds of Formula (XII), (XII'), (XIIa), (XIIb), or (XIIc), R 2 is C1-C6 alkyl, or C1-C6 deuterated alkyl. In some embodiments of compounds of Formula (XII), (XII'), (XIIa), (XIIb), or (XIIc), R 2 is a C1-C6 deuterated alkyl. In some embodiments of compounds of Formula (XII), (XII'), (XIIa), (XIIb), or (XIIc), R 2 is C1-C6 alkyl.

[0280] In some embodiments of compounds of Formula (XII), (XII'), (XIIa), (XIIb), or (XIIc), R 11 is C1-C6 alkyl, C1-C6 haloalkyl, C1-C6 deuterated alkyl, C1-C6 hydroxyalkyl, C1-C6 aminoalkyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; wherein each of alkyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl is independently selected from one or more R 11a In some embodiments of compounds of Formula (XII), (XII'), (XIIa), (XIIb), or (XIIc), R 11 is C1-C6 alkyl, C1-C6 haloalkyl, C1-C6 deuterated alkyl, C1-C6 hydroxyalkyl, C1-C6 aminoalkyl, cycloalkyl, or heterocycloalkyl; wherein each of alkyl, cycloalkyl, and heterocycloalkyl is independently selected from one or more R 11aIn some embodiments of compounds of Formula (XII), (XII'), (XIIa), (XIIb), or (XIIc), R 11 is C-C alkyl, C-C haloalkyl, C-C deuterated alkyl, cycloalkyl, or heterocycloalkyl; wherein each of the alkyl, cycloalkyl, and heterocycloalkyl is independently selected from one or more R 11a In some embodiments of compounds of Formula (XII), (XII'), (XIIa), (XIIb), or (XIIc), R 11 is C1-C6 alkyl, C1-C6 haloalkyl, or cycloalkyl; wherein each of the alkyl and cycloalkyl independently is selected from one or more R 11a In some embodiments of compounds of Formula (XII), (XII'), (XIIa), (XIIb), or (XIIc), R 11 is C1-C6 alkyl, or cycloalkyl; in which case each of the alkyl and cycloalkyl independently may be one or more R 11a In some embodiments of compounds of Formula (XII), (XII'), (XIIa), (XIIb), or (XIIc), R 11 is C-C alkyl, C-C deuterated alkyl, C-C haloalkyl, or cycloalkyl. In some embodiments of compounds of Formula (XII), (XII'), (XIIa), (XIIb), or (XIIc), R 11 is C-C alkyl, C-C haloalkyl, or cycloalkyl. In some embodiments of compounds of Formula (XII), (XII'), (XIIa), (XIIb), or (XIIc), R 11 is a C1-C6 deuterated alkyl. In some embodiments of compounds of Formula (XII), (XII'), (XIIa), (XIIb), or (XIIc), R 11 is C1-C6 alkyl. In some embodiments of compounds of Formula (XII), (XII'), (XIIa), (XIIb), or (XIIc), R 11In some embodiments of compounds of Formula (XII), (XII'), (XIIa), (XIIb), or (XIIc), R 11 is C1-C6 alkyl, C1-C6 deuterated alkyl, or cycloalkyl.

[0281] In some embodiments of compounds of Formula (XII), (XII'), (XIIa), (XIIb), or (XIIc), each R 11a are independently deuterium, halogen, -CN, -OR b , -NR c R d , -C(=O)R a , -C(=O)OR b , -C(=O)NR c R d , C1-C6 alkyl, C1-C6 haloalkyl, C1-C6 deuterated alkyl, C1-C6 hydroxyalkyl, or C1-C6 aminoalkyl. In some embodiments of compounds of Formula (XII), (XII'), (XIIa), (XIIb), or (XIIc), each R 11a are independently deuterium, halogen, -CN, -OR b , -NR c R d , C1-C6 alkyl, C1-C6 haloalkyl, C1-C6 deuterated alkyl, C1-C6 hydroxyalkyl, or C1-C6 aminoalkyl. In some embodiments of compounds of Formula (XII), (XII'), (XIIa), (XIIb), or (XIIc), each R 11a are independently deuterium, halogen, -CN, -OR b , -NR c R d , C1-C6 alkyl, C1-C6 haloalkyl, or C1-C6 deuterated alkyl. In some embodiments of compounds of Formula (XII), (XII'), (XIIa), (XIIb), or (XIIc), each R 11a are independently deuterium, halogen, -CN, -OR b , -NR c R dor C1-C6 alkyl. In some embodiments of compounds of Formula (XII), (XII'), (XIIa), (XIIb), or (XIIc), each R 11a is independently deuterium, halogen, C-C alkyl, C-C haloalkyl, or C-C deuterated alkyl. In some embodiments of compounds of Formula (XII), (XII'), (XIIa), (XIIb), or (XIIc), each R 11a are independently deuterium, halogen, or C1-C6 alkyl.

[0282] In some embodiments of compounds of Formula (XII), (XII'), (XIIa), or (XIIb), R 5 is halogen, -CN, -OR 8 , -SR 8 , -S(=O)R 7 , -S(=O)2R 7 , -NO2, -NR 9 R 10 , -NHS(=O)2R 7 , -S(=O)2NR 9 R 10 , -C(=N-CN)R 7 ,-C(=O)R 7 , -OC(=N-CN)R 7 , -OC(=O)R 7 , -C(=N-CN)OR 8 , -C(=O)OR 8 , -OC(=N-CN)OR 8 , -OC(=O)OR 8 , -C(=N-CN)NR 9 R 10 , -C(=O)NR 9 R 10 , -OC(=N-CN)NR 9 R 10 , -OC(=O)NR 9 R 10 , -NR 8 C(=N-CN)NR 9 R 10 , -NR 8 C(=O)NR 9 R 10 , -NR8 C(=N-CN)R 7 , -NR 8 C(=N-OH)R 7 , -NR 8 C(=N-CN)OR 8 , -NR 8 C(=O)OR 8 , -NR 8 S(=O)(=NR 8 )R 7 , C1-C6 alkyl, C1-C6 haloalkyl, C1-C6 deuterated alkyl, C1-C6 hydroxyalkyl, C1-C6 aminoalkyl, C2-C6 alkenyl, C2-C6 alkynyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; wherein each of alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl independently represents one or more of oxo, deuterium, halogen, -CN, -OR b , -NR c R d , -C(=O)R a , -C(=O)OR b , -C(=O)NR c R d , C1-C6 alkyl, C1-C6 haloalkyl, C1-C6 deuterated alkyl, C1-C6 hydroxyalkyl, C1-C6 aminoalkyl, C1-C6 heteroalkyl, C2-C6 alkenyl, C2-C6 alkynyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, C1-C6 alkyl(cycloalkyl), C1-C6 alkyl(heterocycloalkyl), C1-C6 alkyl(aryl), or C1-C6 alkyl(heteroaryl); wherein each of alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl is independently selected from one or more of oxo, deuterium, halogen, -CN, -OR b , -NR c R d , -C(=O)R a , -C(=O)OR b , -C(=O)NR c R d, optionally substituted with C1-C6 alkyl, or C1-C6 haloalkyl;

[0283] In some embodiments of compounds of Formula (XII), (XII'), (XIIa), or (XIIb), R 5 is halogen, -CN, -OR 8 , -NR 9 R 10 , -C(=O)R 7 , -C(=O)OR 8 , -C(=O)NR 9 R 10 , -NR 8 C(=O)NR 9 R 10 , -NR 8 C(=N-CN)R 7 , -NR 8 C(=O)R 7 , -NR 8 C(=O)OR 8 , -NR 8 S(=O)(=NR 8 )R 7 , C1-C6 alkyl, C1-C6 haloalkyl, C1-C6 deuterated alkyl, C2-C6 alkenyl, C2-C6 alkynyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; wherein each of alkyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl independently represents one or more of oxo, deuterium, halogen, —CN, —OR b , -NR c R d , -C(=O)R a , -C(=O)OR b , -C(=O)NR c R d , C1-C6 alkyl, or C1-C6 haloalkyl.

[0284] In some embodiments of compounds of Formula (XII), (XII'), (XIIa), or (XIIb), R 5 is halogen, -CN, -OR 8 , -NR 9 R 10, -C(=O)R 7 , -C(=O)OR 8 , -C(=O)NR 9 R 10 , -NR 8 C(=O)NR 9 R 10 , -NR 8 C(=N-CN)R 7 , -NR 8 C(=O)OR 8 , -NR 8 S(=O)(=NR 8 )R 7 , C1-C6 alkyl, C1-C6 haloalkyl, C1-C6 deuterated alkyl, C2-C6 alkenyl, C2-C6 alkynyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; wherein each of alkyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl independently represents one or more of oxo, deuterium, halogen, -CN, -OR b , -NR c R d , -C(=O)R a , -C(=O)OR b , -C(=O)NR c R d , C1-C6 alkyl, or C1-C6 haloalkyl.

[0285] In some embodiments of compounds of Formula (XII), (XII'), (XIIa), or (XIIb), R 5 is halogen, -CN, -OR 8 , -NR 9 R 10 , -C(=O)R 7 , -C(=O)OR 8 , -C(=O)NR 9 R 10 , -NR 8 C(=O)NR 9 R 10 , -NR 8 C(=N-CN)R 7 , -NR 8 C(=O)OR 8 , -NR 8S(=O)(=NR 8 )R 7 , C 1- C6 alkyl, C 1- C6 haloalkyl, C 1- C6 deuterated alkyl, C 2- C6 alkenyl, C 2- C alkynyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; wherein each of the alkyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl independently represents one or more of oxo, deuterium, halogen, -CN, -OR b , -NR c R d , -C(=O)R a , -C(=O)OR b , -C(=O)NR c R d , C 1- C6 alkyl, or C 1- Optionally substituted with C6 haloalkyl.

[0286] In some embodiments of compounds of Formula (XII), (XII'), (XIIa), or (XIIb), R 5 -OR 8 , -NR 9 R 10 , -C(=O)R 7 , -C(=O)OR 8 , -C(=O)NR 9 R 10 , -NR 8 C(=O)NR 9 R 10 , -NR 8 C(=N-CN)R 7 , -NR 8 C(=O)R 7 , -NR 8 C(=O)OR 8 , -NR 8 S(=O)(=NR 8 )R 7, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; wherein each of the cycloalkyl, heterocycloalkyl, aryl, and heteroaryl independently represents one or more of oxo, deuterium, halogen, —CN, —OR b , -NR c R d , -C(=O)R a , -C(=O)OR b , -C(=O)NR c R d , C1-C6 alkyl, or C1-C6 haloalkyl.

[0287] In some embodiments of compounds of Formula (XII), (XII'), (XIIa), or (XIIb), R 5 -OR 8 , -NR 9 R 10 , -C(=O)R 7 , -C(=O)OR 8 , -C(=O)NR 9 R 10 , -NR 8 C(=O)NR 9 R 10 , -NR 8 C(=N-CN)R 7 , -NR 8 C(=O)OR 8 , -NR 8 S(=O)(=NR 8 )R 7 , cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; wherein each of the cycloalkyl, heterocycloalkyl, aryl, and heteroaryl independently represents one or more of oxo, deuterium, halogen, —CN, —OR b , -NR c R d , -C(=O)R a , -C(=O)OR b , -C(=O)NR c R d, C1-C6 alkyl, or C1-C6 haloalkyl. In some embodiments of compounds of Formula (XII), (XII'), (XIIa), or (XIIb), R 5 -OR 8 , -NR 9 R 10 , -NR 8 C(=O)R 7 , -NR 8 C(=N-CN)R 7 , -NR 8 S(=O)(=NR 8 )R 7 , or one or more deuterium, halogen, -CN, -OR b , -NR c R d , -C(=O)R a , -C(=O)OR b , -C(=O)NR c R d , aryl optionally substituted with C1-C6 alkyl or C1-C6 haloalkyl.

[0288] In some embodiments of compounds of Formula (XII), (XII'), (XIIa), or (XIIb), R 5 -OR 8 , -NR 9 R 10 , -NR 8 C(=N-CN)R 7 , -NR 8 S(=O)(=NR 8 )R 7 , or one or more deuterium, halogen, -CN, -OR b , -NR c R d , -C(=O)R a , -C(=O)OR b , -C(=O)NR c R d , aryl optionally substituted with C1-C6 alkyl or C1-C6 haloalkyl.

[0289] In some embodiments of compounds of Formula (XII), (XII'), (XIIa), or (XIIb), R5 -OR 8 , -NR 9 R 10 , -NR 8 C(=O)R 7 , cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; wherein each of the cycloalkyl, heterocycloalkyl, aryl, and heteroaryl independently represents one or more of oxo, deuterium, halogen, —CN, —OR b , -NR c R d , -C(=O)R a , -C(=O)OR b , -C(=O)NR c R d , C1-C6 alkyl, or C1-C6 haloalkyl. In some embodiments of compounds of Formula (XII), (XII'), (XIIa), or (XIIb), R 5 is one or more of oxo, deuterium, halogen, -CN, -OR b , -NR c R d , -C(=O)R a , -C(=O)OR b , -C(=O)NR c R d , C1-C6 alkyl, or C1-C6 haloalkyl.

[0290] In some embodiments of compounds of Formula (XII), (XII'), (XIIa), or (XIIb), R 5 is -NR 9 R 10 , -NR 8 C(=O)NR 9 R 10 , or -NR 8 C(=N-CN)R 7 is.

[0291] In some embodiments of compounds of Formula (XII), (XII'), (XIIa), or (XIIb), R 5 is -NR 9 R 10 is.

[0292] In some embodiments of compounds of Formula (XII), (XII'), (XIIa), or (XIIb), R 5 is -NR 9 R 10 or -NR 8 C(=O)NR 9 R 10 is.

[0293] In some embodiments of compounds of Formula (XII), (XII'), (XIIa), or (XIIb), R 5 is -NR 8 C(=N-CN)R 7 is.

[0294] In some embodiments of compounds of Formula (XII), (XII'), (XIIa), or (XIIb), R 5 is -NR 8 S(=O)(=NR 8 )R 7 is.

[0295] In some embodiments of compounds of Formula (XII), (XII'), (XIIa), or (XIIb), R 5 is -NR 8 C(=O)NR 9 R 10 or -NR 8 C(=O)R 7 is.

[0296] In some embodiments of compounds of Formula (XII), (XII'), (XIIa), or (XIIb), R 5 is -NR 8 C(=O)NR 9 R 10 is.

[0297] In some embodiments of compounds of Formula (XII), (XII'), (XIIa), or (XIIb), R 5 is -NR 8 C(=O)R 7 is.

[0298] In some embodiments of compounds of Formula (XII), (XII'), (XIIa), or (XIIb), R 5 is -NR 8 C(=O)R 7 isn't it.

[0299] In some embodiments of compounds of Formula (XII), (XII'), (XIIa), or (XIIb), R 5 is -NR 8 C(=O)NR 9 R 10 , or one or more of oxo, deuterium, halogen, -CN, -OR b , -NR c R d , -C(=O)R a , -C(=O)OR b , -C(=O)NR c R d , C1-C6 alkyl, C1-C6 haloalkyl, C1-C6 deuterated alkyl, C1-C6 hydroxyalkyl, C1-C6 aminoalkyl, C1-C6 heteroalkyl, C2-C6 alkenyl, C2-C6 alkynyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, C1-C6 alkyl(cycloalkyl), C1-C6 alkyl(heterocycloalkyl), C1-C6 alkyl(aryl), or heterocycloalkyl optionally substituted with C1-C6 alkyl(heteroaryl); wherein each of alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl independently represents one or more of oxo, deuterium, halogen, —CN, —OR b , -NR c R d , -C(=O)R a , -C(=O)OR b , -C(=O)NR c R d , optionally substituted with C1-C6 alkyl or C1-C6 haloalkyl.

[0300] In some embodiments of compounds of Formula (XII), (XII'), (XIIa), or (XIIb), R5 is one or more of oxo, deuterium, halogen, -CN, -OR b , -NR c R d , -C(=O)R a , -C(=O)OR b , -C(=O)NR c R d , C1-C6 alkyl, C1-C6 haloalkyl, C1-C6 deuterated alkyl, C1-C6 hydroxyalkyl, C1-C6 aminoalkyl, C1-C6 heteroalkyl, C2-C6 alkenyl, C2-C6 alkynyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, C1-C6 alkyl(cycloalkyl), C1-C6 alkyl(heterocycloalkyl), C1-C6 alkyl(aryl), or heterocycloalkyl optionally substituted with C1-C6 alkyl(heteroaryl); wherein each of alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl independently represents one or more of oxo, deuterium, halogen, —CN, —OR b , -NR c R d , -C(=O)R a , -C(=O)OR b , -C(=O)NR c R d , optionally substituted with C1-C6 alkyl or C1-C6 haloalkyl.

[0301] In some embodiments of compounds of Formula (XII), (XII'), (XIIa), or (XIIb), R 5 is one or more of oxo, deuterium, halogen, -CN, -OR b , -NR c R d, C1-C6 alkyl, C1-C6 haloalkyl, C1-C6 deuterated alkyl, C1-C6 hydroxyalkyl, C1-C6 aminoalkyl, C1-C6 heteroalkyl, C2-C6 alkenyl, C2-C6 alkynyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, C1-C6 alkyl(cycloalkyl), or heterocycloalkyl optionally substituted with C1-C6 alkyl(heterocycloalkyl); wherein each of alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl independently represents one or more of oxo, deuterium, halogen, —CN, —OR b , -NR c R d , -C(=O)R a , -C(=O)OR b , -C(=O)NR c R d , optionally substituted with C1-C6 alkyl or C1-C6 haloalkyl.

[0302] In some embodiments of compounds of Formula (XII), (XII'), (XIIa), or (XIIb), R 5 is one or more oxo, halogen, -OR b , C1-C6 alkyl, C1-C6 haloalkyl, C1-C6 deuterated alkyl, C1-C6 hydroxyalkyl, C1-C6 aminoalkyl, C1-C6 heteroalkyl, C2-C6 alkynyl, cycloalkyl, heterocycloalkyl, aryl, C1-C6 alkyl(cycloalkyl), or heterocycloalkyl optionally substituted with C1-C6 alkyl(heterocycloalkyl); wherein each of alkyl, alkynyl, cycloalkyl, heterocycloalkyl, and aryl independently represents one or more of oxo, deuterium, halogen, —CN, —OR b , -NR c R d , -C(=O)R a , -C(=O)OR b , -C(=O)NR c R d, optionally substituted with C1-C6 alkyl or C1-C6 haloalkyl.

[0303] In some embodiments of compounds of Formula (XII), (XII'), (XIIa), or (XIIb), R 5 The heterocycloalkyl of [ka] is.

[0304] In some embodiments of compounds of Formula (XII), (XII'), (XIIa), or (XIIb), R 5 The heterocycloalkyl of [ka] is.

[0305] In some embodiments of compounds of Formula (XII), (XII'), (XIIa), or (XIIb), R 7 is C-C alkyl, C-C haloalkyl, C-C deuterated alkyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; wherein each of the alkyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl is independently optionally substituted with one or more oxo, deuterium, halogen, —CN, —OH, —OMe, —NH, —C(═O)Me, —C(═O)OH, —C(═O)OMe, C-C alkyl, or C-C haloalkyl. In some embodiments of compounds of Formula (XII), (XII′), (XIIa), or (XIIb), R 7is C-C alkyl, cycloalkyl, or heterocycloalkyl; wherein each alkyl, cycloalkyl, or heterocycloalkyl is independently optionally substituted with one or more oxo, deuterium, halogen, —CN, —OH, —OMe, —NH, —C(═O)Me, —C(═O)OH, —C(═O)OMe, C-C alkyl, or C-C haloalkyl. In some embodiments of compounds of Formula (XII), (XII′), (XIIa), or (XIIb), R 7 is C-C alkyl, C-C haloalkyl, C-C deuterated alkyl, or cycloalkyl; wherein each of the alkyl and cycloalkyl is independently optionally substituted with one or more of oxo, deuterium, halogen, -CN, -OH, -OMe, -NH, -C(=O)Me, -C(=O)OH, -C(=O)OMe, C-C alkyl, or C-C haloalkyl. In some embodiments of compounds of Formula (XII), (XII'), (XIIa), or (XIIb), R 7 is C-C alkyl, or cycloalkyl; wherein each of the alkyl and cycloalkyl is independently optionally substituted with one or more of oxo, deuterium, halogen, —CN, —OH, —OMe, —NH, —C(═O)Me, —C(═O)OH, —C(═O)OMe, C-C alkyl, or C-C haloalkyl. In some embodiments of compounds of Formula (XII), (XII′), (XIIa), or (XIIb), R 7 is cycloalkyl optionally substituted with one or more oxo, deuterium, halogen, —CN, —OH, —OMe, —NH, —C(═O)Me, —C(═O)OH, —C(═O)OMe, C-C alkyl, or C-C haloalkyl. In some embodiments of compounds of Formula (XII), (XII′), (XIIa), or (XIIb), R 7 is unsubstituted cycloalkyl. In some embodiments of compounds of Formula (XII), (XII'), (XIIa), or (XIIb), R 7is heterocycloalkyl optionally substituted with one or more oxo, deuterium, halogen, —CN, —OH, —OMe, —NH, —C(═O)Me, —C(═O)OH, —C(═O)OMe, C-C alkyl, or C-C haloalkyl. In some embodiments of compounds of Formula (XII), (XII′), (XIIa), or (XIIb), R 7 is an unsubstituted heterocycloalkyl.

[0306] In some embodiments of compounds of Formula (XII), (XII'), (XIIa), or (XIIb), R 8 is hydrogen, CN, C-C alkyl, C-C haloalkyl, C-C deuterated alkyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; wherein each of the alkyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl is independently optionally substituted with one or more oxo, deuterium, halogen, —CN, —OH, —OMe, —NH, —C(═O)Me, —C(═O)OH, —C(═O)OMe, C-C alkyl, or C-C haloalkyl. In some embodiments of compounds of Formula (XII), (XII′), (XIIa), or (XIIb), R 8 is hydrogen, CN, C-C alkyl, C-C haloalkyl, C-C deuterated alkyl, or cycloalkyl; wherein each of alkyl, cycloalkyl, and heterocycloalkyl is independently optionally substituted with one or more oxo, deuterium, halogen, —CN, —OH, —OMe, —NH, —C(═O)Me, —C(═O)OH, —C(═O)OMe, C-C alkyl, or C-C haloalkyl.

[0307] In some embodiments of compounds of Formula (XII), (XII'), (XIIa), or (XIIb), R 9 and R 10is independently hydrogen, C-C alkyl, C-C haloalkyl, C-C deuterated alkyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; wherein each of the alkyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl is independently optionally substituted with one or more oxo, deuterium, halogen, —CN, —OH, —OMe, —NH, —C(═O)Me, —C(═O)OH, —C(═O)OMe, C-C alkyl, C-C deuterated alkyl, C-C haloalkyl, or C-C hydroxyalkyl. In some embodiments of a compound of Formula (XII), (XII′), (XIIa), or (XIIb), R 9 and R 10 are independently hydrogen, C-C alkyl, C-C haloalkyl, C-C deuterated alkyl, or cycloalkyl; wherein each of alkyl, cycloalkyl, and heterocycloalkyl is independently optionally substituted with one or more oxo, deuterium, halogen, —CN, —OH, —OMe, —NH, —C(═O)Me, —C(═O)OH, —C(═O)OMe, C-C alkyl, C-C deuterated alkyl, C-C haloalkyl, or C-C hydroxyalkyl.

[0308] In some embodiments of compounds of Formula (XII), (XII'), (XIIa), or (XIIb), R 9 and R 10 together with the nitrogen atom to which they are attached form a heterocycloalkyl optionally substituted with one or more oxo, deuterium, halogen, —CN, —OH, —OMe, —NH, —C(═O)Me, —C(═O)OH, —C(═O)OMe, C-C alkyl, or C-C haloalkyl. In some embodiments of compounds of Formula (XII), (XII′), (XIIa), or (XIIb), R 9 and R 10together with the nitrogen atom to which they are attached form a C2-C8 heterocycloalkyl optionally substituted with one or more oxo, deuterium, halogen, -CN, -OH, -OMe, -NH2, -C(=O)Me, -C(=O)OH, -C(=O)OMe, C1-C6 alkyl, or C1-C6 haloalkyl. In some embodiments of compounds of Formula (XII), (XII'), (XIIa), or (XIIb), R 9 and R 10 together with the nitrogen atom to which they are attached form a bicyclic heterocycloalkyl or spiroheterocycloalkyl optionally substituted with one or more oxo, deuterium, halogen, —CN, —OH, —OMe, —NH, —C(═O)Me, —C(═O)OH, —C(═O)OMe, C-C alkyl, or C-C haloalkyl. In some embodiments of compounds of Formula (XII), (XII′), (XIIa), or (XIIb), R 9 and R 10 together with the nitrogen atom to which they are attached form a heterocycloalkyl selected from aziridinyl, azetidinyl, pyrrolidinyl, piperidinyl, 2-azabicyclo[1.1.1]pentanyl, or 2-azaspiro[3.3]heptanyl, each optionally substituted with one or more oxo, deuterium, halogen, —CN, —OH, —OMe, —NH, —C(═O)Me, —C(═O)OH, —C(═O)OMe, C-C alkyl, or C-C haloalkyl.

[0309] In some embodiments of the compound of Formula (XII), the compound is a compound of Formula (XIIc): [ka] In the formula, R 5a is deuterium, halogen, -CN, -OR b , -NR c R d , -C(=O)R a , -C(=O)OR b , -C(=O)NR c R d, C1-C6 alkyl, C1-C6 haloalkyl, C1-C6 deuterated alkyl, C1-C6 hydroxyalkyl, C1-C6 aminoalkyl, C1-C6 heteroalkyl, C2-C6 alkenyl, C2-C6 alkynyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, C1-C6 alkyl(cycloalkyl), C1-C6 alkyl(heterocycloalkyl), C1-C6 alkyl(aryl), or C1-C6 alkyl(heteroaryl); wherein each of alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl independently represents one or more of oxo, deuterium, halogen, —CN, —OR b , -NR c R d , -C(=O)R a , -C(=O)OR b , -C(=O)NR c R d , optionally substituted with C1-C6 alkyl or C1-C6 haloalkyl.

[0310] In some embodiments of the compound of Formula (XIIc), R 5a is deuterium, halogen, -CN, -OR b , -NR c R d , C1-C6 alkyl, C1-C6 haloalkyl, C1-C6 deuterated alkyl, C1-C6 hydroxyalkyl, C1-C6 aminoalkyl, C1-C6 heteroalkyl, C2-C6 alkynyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, C1-C6 alkyl(cycloalkyl), C1-C6 alkyl(heterocycloalkyl), C1-C6 alkyl(aryl), or C1-C6 alkyl(heteroaryl); wherein each of alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl independently represents one or more of oxo, deuterium, halogen, —CN, —OR b , -NR c R d , -C(=O)R a , -C(=O)OR b, -C(=O)NR c R d , optionally substituted with C1-C6 alkyl or C1-C6 haloalkyl.

[0311] In some embodiments of the compound of Formula (XIIc), R 5a is halogen, -OR b , C1-C6 alkyl, C1-C6 haloalkyl, C1-C6 deuterated alkyl, C1-C6 hydroxyalkyl, C1-C6 aminoalkyl, C1-C6 heteroalkyl, C2-C6 alkynyl, cycloalkyl, heterocycloalkyl, aryl, C1-C6 alkyl(cycloalkyl), or C1-C6 alkyl(heterocycloalkyl); wherein each of alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, and aryl independently represents one or more of oxo, deuterium, halogen, —CN, —OR b , -NR c R d , -C(=O)R a , -C(=O)OR b , -C(=O)NR c R d , optionally substituted with C1-C6 alkyl or C1-C6 haloalkyl.

[0312] Disclosed herein is a compound of formula (XIII) below, or a pharmaceutically acceptable salt, solvate, or stereoisomer thereof: [ka] During the ceremony: Ring B is cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; R 3 is hydrogen, C 1- C6 alkyl, C 1- C6 haloalkyl, or C 1- C6 deuterated alkyl; R 4 is hydrogen, deuterium, halogen, -CN, -OR b , -SR b , -S(=O)Ra , -S(=O)2R a , -NO2, -NR c R d , -NHS(=O)2R a , -S(=O)2NR c R d , -C(=O)R a , -OC(=O)R a , -C(=O)OR b , -OC(=O)OR b , -C(=O)NR c R d , -OC(=O)NR c R d , -NR b C(=O)NR c R d , -NR b C(=O)R a , -NR b C(=O)OR b , -P(=O)R b R b , C 1- C6 alkyl, C 1- C6 haloalkyl, C 1- C6 deuterated alkyl, C 1- C6 hydroxyalkyl, C 1- C6 amino alkyl, C 2- C6 alkenyl, or C 2- C6 alkynyl; or R 3 and R 4 together form an optionally substituted ring; L is a bond or -C(=O)-; Ring A is a cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; each of which is selected from the group consisting of one or more R A optionally replaced by; Each R A are independently deuterium, halogen, -CN, -OR b , -SR b , -S(=O)R a , -S(=O)2R a , -NO2, -NR c R d , -NHS(=O)2Ra , -S(=O)2NR c R d , -C(=O)R a , -OC(=O)R a , -C(=O)OR b , -OC(=O)OR b , -C(=O)NR c R d , -OC(=O)NR c R d , -NR b C(=O)NR c R d , -NR b C(=O)R a , -NR b C(=O)OR b , C 1- C6 alkyl, C 1- C6 haloalkyl, C 1- C6 deuterated alkyl, C 1- C6 hydroxyalkyl, C 1- C6 amino alkyl, C 2- C6 alkenyl, C 2- C6 alkynyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; wherein each of the alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl independently represents one or more of oxo, deuterium, halogen, -CN, -OR b , -NR c R d , -C(=O)R a , -C(=O)OR b , -C(=O)NR c R d , C 1- C6 alkyl, or C 1- optionally substituted with C6 haloalkyl; or two R on the same carbon A together form oxo; or -L-ring A is absent; Each X is independently -CR x -or-N-; Each R Xare independently hydrogen, deuterium, halogen, -CN, -OR b , -SR b , -S(=O)R a , -S(=O)2R a , -NO2, -NR c R d , -NHS(=O)2R a , -S(=O)2NR c R d , -C(=O)R a , -OC(=O)R a , -C(=O)OR b , -OC(=O)OR b , -C(=O)NR c R d , -OC(=O)NR c R d , -NR b C(=O)NR c R d , -NR b C(=O)R a , -NR b C(=O)OR b , C 1- C6 alkyl, C 1- C6 haloalkyl, C 1- C6 deuterated alkyl, C 1- C6 hydroxyalkyl, C 1- C6 amino alkyl, C 2- C6 alkenyl, or C 2- C6 alkynyl; R 5 is halogen, -CN, -OR 8 , -SR 8 , -S(=O)R 7 , -S(=O)2R 7 , -NO2, -NR 9 R 10 , -NR 8 S(=O)R 7 , -NR 8 S(=O)2R 7 , -S(=O)2NR 9 R 10 , -C(=N-CN)R 7 ,-C(=O)R 7 , -OC(=N-CN)R7 , -OC(=O)R 7 , -C(=N-CN)OR 8 , -C(=O)OR 8 , -OC(=N-CN)OR 8 , -OC(=O)OR 8 , -C(=N-...

Claims

1. A compound of formula (XII) represented by the following formula, or a pharma- ceutically acceptable salt thereof: 【Chemistry 1】 During the ceremony: A partial structure in formula (XII) represented by the following formula: 【Chemistry 2】 is a group represented by the following formula: 【Chemistry 3】 or 【Chemistry 4】 and Ring B is phenyl or pyridyl; R 16 is -C(=O)R 11 and R 3 is hydrogen, C 1- C 6 Alkyl, C 1- C 6 Haloalkyl, and C 1- C 6 deuterated alkyl; R 4 is hydrogen, deuterium, halogen, -CN, -OR b , -SR b , -S(=O)R a , -S(=O) 2 R a , -NO 2 , -NR c R d , -NHS(=O) 2 R a , -S(=O) 2 NR c R d , -C(=O)R a , -OC(=O)R a , -C(=O)OR b , -OC(=O)OR b , -C(=O)NR c R d , -OC(=O)NR c R d , -NR b C(=O)NR c R d , -NR b C(=O)R a , -NR b C(=O)OR b , -P(=O)R b R b , C 1- C 6 Alkyl, C 1- C 6 Haloalkyl, C 1- C 6 Deuterated alkyl, C 1- C 6 Hydroxyalkyl, C 1- C 6 Aminoalkyl, C 2- C 6 Alkenyl, and C 2- C 6 alkynyl; L is a bond; Ring A is a 5-membered heteroaryl; Ring A is one or more R A optionally replaced by; Each R A are independently deuterium, halogen, -CN, -OR b , -SR b , -S(=O)R a , -S(=O) 2 R a , -NO 2 , -NR c R d , -NHS(=O) 2 R a , -S(=O) 2 NR c R d , -C(=O)R a , -OC(=O)R a , -C(=O)OR b , -OC(=O)OR b , -C(=O)NR c R d , -OC(=O)NR c R d , -NR b C(=O)NR c R d , -NR b C(=O)R a , -NR b C(=O)OR b , C 1- C 6 Alkyl, C 1- C 6 Haloalkyl, C 1- C 6 Deuterated alkyl, C 1- C 6 Hydroxyalkyl, C 1- C 6 Aminoalkyl, C 2- C 6 Alkenyl, C 2- C 6 and wherein each of alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl is independently selected from the group consisting of one or more of oxo, deuterium, halogen, -CN, -OR. b , -NR c R d , -C(=O)R a , -C(=O)OR b , -C(=O)NR c R d , C 1- C 6 Alkyl, or C 1- C 6 optionally substituted with haloalkyl; Each R X are independently hydrogen, deuterium, halogen, -CN, -OR b , -SR b , -S(=O)R a , -S(=O) 2 R a , -NO 2 , -NR c R d , -NHS(=O) 2 R a , -S(=O) 2 NR c R d , -C(=O)R a , -OC(=O)R a , -C(=O)OR b , -OC(=O)OR b , -C(=O)NR c R d , -OC(=O)NR c R d , -NR b C(=O)NR c R d , -NR b C(=O)R a , -NR b C(=O)OR b , C 1- C 6 Alkyl, C 1- C 6 Haloalkyl, C 1- C 6 Deuterated alkyl, C 1- C 6 Hydroxyalkyl, C 1- C 6 Aminoalkyl, C 2- C 6 Alkenyl, and C 2- C 6 alkynyl; R 5 -NR 9 R 10 , -NR 8 S(=O)R 7 , -NR 8 C(=O)NR 9 R 10 , -NR 8 C(=O)R 7 and heterocycloalkyl; wherein heterocycloalkyl is independently selected from the group consisting of one or more of oxo, deuterium, halogen, -CN, -OR b , -NR c R d , -C(=O)R a , -C(=O)OR b , -C(=O)NR c R d , C 1- C 6 Alkyl, C 1- C 6 Haloalkyl, C 1- C 6 Deuterated alkyl, C 1- C 6 Hydroxyalkyl, C 1- C 6 Aminoalkyl, C 1 -C 6 Heteroalkyl, C 2- C 6 Alkenyl, or C 2- C 6 Alkynyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, C 1 -C 6 Alkyl (cycloalkyl), C 1 -C 6 Alkyl (heterocycloalkyl), C 1 -C 6 Alkyl (aryl), or C 1 -C 6 and optionally substituted with alkyl (heteroaryl); in which each of alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl independently is selected from one or more of oxo, deuterium, halogen, -CN, -OR b , -NR c R d , -C(=O)R a , -C(=O)OR b , -C(=O)NR c R d , C 1- C 6 Alkyl, or C 1- C 6 optionally substituted with haloalkyl; R 7 is C 1- C 6 Alkyl, C 1- C 6 Haloalkyl, C 1- C 6 Deuterated alkyl, C 1- C 6 Hydroxyalkyl, C 1- C 6 Aminoalkyl, C 2- C 6 Alkenyl, C 2- C 6 is selected from the group consisting of alkynyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl; wherein each of alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl independently represents one or more of oxo, deuterium, halogen, -CN, -OH, -OMe, -NH 2 , -C(=O)Me, -C(=O)OH, -C(=O)OMe, C 1- C 6 Alkyl, or C 1- C 6 optionally substituted with haloalkyl; Each R 8 are independently hydrogen, CN, C 1- C 6 Alkyl, C 1- C 6 Haloalkyl, C 1- C 6 Deuterated alkyl, C 1- C 6 Hydroxyalkyl, C 1- C 6 Aminoalkyl, C 2- C 6 Alkenyl, C 2- C 6 Selected from the group consisting of alkynyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl; In this case, each of the alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl independently represents one or more of oxo, deuterium, halogen, -CN, -OH, -OMe, -NH 2 , -C(=O)Me, -C(=O)OH, -C(=O)OMe, C 1- C 6 Alkyl, or C 1- C 6 optionally substituted with haloalkyl; R 9 and R 10 are independently hydrogen, C 1- C 6 Alkyl, C 1- C 6 Haloalkyl, C 1- C 6 Deuterated alkyl, C 1- C 6 Hydroxyalkyl, C 1- C 6 Aminoalkyl, C 2- C 6 Alkenyl, C 2- C 6 is selected from the group consisting of alkynyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl; wherein each of alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl independently represents one or more of oxo, deuterium, halogen, -CN, -OH, -OMe, -NH 2 , -C(=O)Me, -C(=O)OH, -C(=O)OMe, C 1- C 6 Alkyl, C 1- C 6 Deuterated alkyl, C 1- C 6 Haloalkyl, C 1- C 6 Hydroxyalkyl, C 1- C 6 optionally substituted with hydroxydeuterated alkyl, cycloalkyl, or heterocycloalkyl; or R 9 and R 10 together with the nitrogen atom to which they are attached, one or more of oxo, deuterium, halogen, -CN, -OH, -OMe, -NH 2 , -C(=O)Me, -C(=O)OH, -C(=O)OMe, C 1- C 6 Alkyl, or C 1- C 6 forming a heterocycloalkyl optionally substituted with haloalkyl; or R 8 and R 9 together with the atom to which they are attached, one or more of oxo, deuterium, halogen, -CN, -OH, -OMe, -NH 2 , -C(=O)Me, -C(=O)OH, -C(=O)OMe, C 1- C 6 Alkyl, or C 1- C 6 forming a heterocycloalkyl optionally substituted with haloalkyl; R 11 is C 1 -C 6 Alkyl, C 1 -C 6 Deuterated alkyl, C 1 -C 6 haloalkyl, and cycloalkyl; where each of alkyl and cycloalkyl is independently selected from the group consisting of one or more R 11a optionally replaced by; Each R 11a are independently deuterium, halogen, -CN, -OR b , -SR b , -S(=O)R a , -S(=O) 2 R a , -NO 2 , -NR c R d , -NHS(=O) 2 R a , -S(=O) 2 NR c R d , -C(=O)R a , -OC(=O)R a , -C(=O)OR b , -OC(=O)OR b , -C(=O)NR c R d , -OC(=O)NR c R d , -NR b C(=O)NR c R d , -NR b C(=O)R a , -NR b C(=O)OR b , C 1- C 6 Alkyl, C 1- C 6 Haloalkyl, C 1- C 6 Deuterated alkyl, C 1- C 6 Hydroxyalkyl, C 1- C 6 Aminoalkyl, C 2- C 6 Alkenyl, and C 2- C 6 alkynyl; Each R a is independent, C 1- C 6 Alkyl, C 1- C 6 Haloalkyl, C 1- C 6 Deuterated alkyl, C 1- C 6 Hydroxyalkyl, C 1- C 6 Aminoalkyl, C 2- C 6 Alkenyl, C 2- C 6 is selected from the group consisting of alkynyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl; wherein each of alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl independently represents one or more of oxo, deuterium, halogen, -CN, -OH, -OMe, -NH 2 , -C(=O)Me, -C(=O)OH, -C(=O)OMe, C 1- C 6 Alkyl, or C 1- C 6 optionally substituted with haloalkyl; Each R b are independently hydrogen, C 1- C 6 Alkyl, C 1- C 6 Haloalkyl, C 1- C 6 Deuterated alkyl, C 1- C 6 Hydroxyalkyl, C 1- C 6 Aminoalkyl, C 2- C 6 Alkenyl, C 2- C 6 is selected from the group consisting of alkynyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl; wherein each of alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl independently represents one or more of oxo, deuterium, halogen, -CN, -OH, -OMe, -NH 2 , -C(=O)Me, -C(=O)OH, -C(=O)OMe, C 1- C 6 Alkyl, or C 1- C 6 optionally substituted with haloalkyl; Each R c and R d are independently hydrogen, C 1- C 6 Alkyl, C 1- C 6 Haloalkyl, C 1- C 6 Deuterated alkyl, C 1- C 6 Hydroxyalkyl, C 1- C 6 Aminoalkyl, C 2- C 6 Alkenyl, C 2- C 6 is selected from the group consisting of alkynyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl; wherein each of alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl independently represents one or more of oxo, deuterium, halogen, -CN, -OH, -OMe, -NH 2 , -C(=O)Me, -C(=O)OH, -C(=O)OMe, C 1- C 6 Alkyl, or C 1- C 6 optionally substituted with haloalkyl; or R c and R d together with the nitrogen atom to which they are attached, one or more of oxo, deuterium, halogen, -CN, -OH, -OMe, -NH 2 , -C(=O)Me, -C(=O)OH, -C(=O)OMe, C 1- C 6 Alkyl, or C 1- C 6 Compounds that form heterocycloalkyl optionally substituted with haloalkyl.

2. 10. A compound according to claim 1, or a pharma- ceutically acceptable salt thereof, Each R A are independently deuterium, halogen, C 1- C 6 Alkyl, C 1- C 6 Haloalkyl, and C 1- C 6 A compound selected from the group consisting of deuterated alkyls.

3. 3. A compound according to claim 1 or 2, or a pharma- ceutically acceptable salt thereof, R 4 Hydrogen, deuterium, halogens, -CN, -OR b , -NR c R d , -C(=O)R a , -C(=O)OR b , -C(=O)NR c R d , -OC(=O)NR c R d , C 1- C 6 Alkyl, C 1- C 6 Haloalkyl, and C 1- C 6 A compound which is a deuterated alkyl.

4. The compound according to any one of claims 1 to 3, wherein the compound is of formula (XIIa), or a pharma- ceutically acceptable salt thereof: 【Chemistry 5】 During the ceremony: A partial structure in formula (XIIa) represented by the following formula: 【Chemistry 6】 is a group represented by the following formula: 【Chemistry 7】 or 【Chemistry 8】 and R 3 is hydrogen; R 4 is hydrogen or -OR b and In the formula, R x , R 5 , and R 16 A compound as defined in claim 1.

5. A compound according to any one of claims 1 to 4, or a pharma- ceutically acceptable salt thereof, R 3 A compound in which is hydrogen.

6. A compound according to any one of claims 1 to 5, or a pharma- ceutically acceptable salt thereof, A partial structure in formula (XII) or formula (XIIa) represented by the following formula: 【Chemistry 9】 is a group represented by the following formula: 【Chemistry 10】 or 【Chemistry 11】 A compound.

7. A compound according to any one of claims 1 to 6, or a pharma- ceutically acceptable salt thereof, R 5 But NR 8 C(=O)R 7 In this case, R 7 but one or more of oxo, deuterium, halogen, -CN, -OH, -OMe, -NH 2 , -C(=O)Me, -C(=O)OH, -C(=O)OMe, C 1- C 6 Alkyl, or C 1- C 6 A compound which is a cycloalkyl optionally substituted with a haloalkyl.

8. A compound according to any one of claims 1 to 6, or a pharma- ceutically acceptable salt thereof, R 5 is one or more of oxo, deuterium, halogen, -CN, -OR b , -NR c R d , -C(=O)R a , -C(=O)OR b , -C(=O)NR c R d , C 1 -C 6 Alkyl, C 1 -C 6 Haloalkyl, C 1 -C 6 Deuterated alkyl, C 1 -C 6 Hydroxyalkyl, C 1 -C 6 Aminoalkyl, C 1 -C 6 Heteroalkyl, C 2 -C 6 Alkenyl, C 2 -C 6 Alkynyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, C 1 -C 6 Alkyl (cycloalkyl), C 1 -C 6 Alkyl (heterocycloalkyl), C 1 -C 6 Alkyl (aryl), or C 1 -C 6 heterocycloalkyl optionally substituted with alkyl(heteroaryl); where alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl each independently represent one or more of oxo, deuterium, halogen, -CN, -OR b , -NR c R d , -C(=O)R a , -C(=O)OR b , -C(=O)NR c R d , C 1 -C 6 Alkyl or C 1 -C 6 A compound optionally substituted with haloalkyl.

9. A compound according to any one of claims 1 to 6, or a pharma- ceutically acceptable salt thereof, R 5 But -NR 8 C(=O)NR 9 R 10 A compound.

10. A compound according to any one of claims 1 to 6 and 9, or a pharma- ceutically acceptable salt thereof, R 9 and R 10 together with the nitrogen atom to which they are attached, one or more of oxo, deuterium, halogen, -CN, -OH, -OMe, -NH 2 , -C(=O)Me, -C(=O)OH, -C(=O)OMe, C 1- C 6 Alkyl, or C 1- C 6 Compounds that form heterocycloalkyl optionally substituted with haloalkyl.

11. 10. A compound according to claim 1, or a pharma- ceutically acceptable salt thereof: The compound is represented by formula (XIII): 【Chemistry 12】 During the ceremony: A partial structure in formula (XIII) represented by the following formula: 【Chemistry 13】 is a group represented by the following formula: 【Chemistry 14】 and Ring B is phenyl or pyridyl; R 3 is hydrogen, C 1- C 6 Alkyl, C 1- C 6 Haloalkyl, and C 1- C 6 deuterated alkyl; R 4 is hydrogen, deuterium, halogen, -CN, -OR b , -NR c R d , -C(=O)R a , -C(=O)OR b , -(=O)NR c R d , -OC(=O)NR c R d , C 1 C 6 alkyl, C 1 C 6 Haloalkyl, and C 1 C 6 deuterated alkyl; L is a bond; Ring A is one or more R A is a 5-membered heteroaryl optionally substituted with Each R A are independently deuterium, halogen, -CN, -OR b , -SR b , -S(=O)R a , -S(=O) 2 R a , -NO 2 , -NR c R d , -NHS(=O) 2 R a , -S(=O) 2 NR c R d , -C(=O)R a , -OC(=O)R a , -C(=O)OR b , -OC(=O)OR b , -C(=O)NR c R d , -OC(=O)NR c R d , -NR b C(=O)NR c R d , -NR b C(=O)R a , -NR b C(=O)OR b , C 1- C 6 Alkyl, C 1- C 6 Haloalkyl, C 1- C 6 Deuterated alkyl, C 1- C 6 Hydroxyalkyl, C 1- C 6 Aminoalkyl, C 2- C 6 Alkenyl, C 2- C 6 and wherein each of alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl is independently selected from the group consisting of one or more of oxo, deuterium, halogen, -CN, -OR. b , -NR c R d , -C(=O)R a , -C(=O)OR b , -C(=O)NR c R d , C 1- C 6 Alkyl, or C 1- C 6 optionally substituted with haloalkyl; R 5 is NR 8 C(=O)R 7 or -NR 8 C(=O)NR 9 R 10 and R 7 is C 1- C 6 Alkyl, C 1- C 6 Haloalkyl, C 1- C 6 Deuterated alkyl, C 1- C 6 Hydroxyalkyl, C 1- C 6 Aminoalkyl, C 2- C 6 Alkenyl, C 2- C 6 is selected from the group consisting of alkynyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl; wherein each of alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl independently represents one or more of oxo, deuterium, halogen, -CN, -OH, -OMe, -NH 2 , -C(=O)Me, -C(=O)OH, -C(=O)OMe, C 1- C 6 Alkyl, or C 1- C 6 optionally substituted with haloalkyl; Each R 8 are independently hydrogen, CN, C 1- C 6 Alkyl, C 1- C 6 Haloalkyl, C 1- C 6 Deuterated alkyl, C 1- C 6 Hydroxyalkyl, C 1- C 6 Aminoalkyl, C 2- C 6 Alkenyl, C 2- C 6 is selected from the group consisting of alkynyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl; wherein each of alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl independently represents one or more of oxo, deuterium, halogen, -CN, -OH, -OMe, -NH 2 , -C(=O)Me, -C(=O)OH, -C(=O)OMe, C 1- C 6 Alkyl, or C 1- C 6 optionally substituted with haloalkyl; R 9 and R 10 are independently hydrogen, C 1- C 6 Alkyl, C 1- C 6 Haloalkyl, C 1- C 6 Deuterated alkyl, C 1- C 6 Hydroxyalkyl, C 1- C 6 Aminoalkyl, C 2- C 6 Alkenyl, C 2- C 6 is selected from the group consisting of alkynyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl; wherein each of alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl independently represents one or more of oxo, deuterium, halogen, -CN, -OH, -OMe, -NH 2 , -C(=O)Me, -C(=O)OH, -C(=O)OMe, C 1- C 6 Alkyl, C 1- C 6 Deuterated alkyl, C 1- C 6 Haloalkyl, C 1- C 6 Hydroxyalkyl, C 1- C 6 optionally substituted with hydroxydeuterated alkyl, cycloalkyl, or heterocycloalkyl; or R 9 and R 10 together with the nitrogen atom to which they are attached, one or more of oxo, deuterium, halogen, -CN, -OH, -OMe, -NH 2 , -C(=O)Me, -C(=O)OH, -C(=O)OMe, C 1- C 6 Alkyl, or C 1- C 6 forming a heterocycloalkyl optionally substituted with haloalkyl; or R 8 and R 9 together with the atom to which they are attached, one or more of oxo, deuterium, halogen, -CN, -OH, -OMe, -NH 2 , -C(=O)Me, -C(=O)OH, -C(=O)OMe, C 1- C 6 Alkyl, or C 1- C 6 forming a heterocycloalkyl optionally substituted with haloalkyl; R 11 is C 1 -C 6 Alkyl, C 1 -C 6 Deuterated alkyl, C 1 -C 6 haloalkyl, and cycloalkyl; where each of the alkyl and cycloalkyl is independently selected from the group consisting of one or more R 11a each R 11a are independently deuterium, halogen, -CN, -OR b , -SR b , -S(=O)R a , -S(=O) 2 R a , -NO 2 , -NR c R d , -NHS(=O) 2 R a , -S(=O) 2 NR c R d , -C(=O)R a , -OC(=O)R a , -C(=O)OR b , -OC(=O)OR b , -C(=O)NR c R d , -OC(=O)NR c R d , -NR b C(=O)NR c R d , -NR b C(=O)R a , -NR b C(=O)OR b , C 1- C 6 Alkyl, C 1- C 6 Haloalkyl, C 1- C 6 Deuterated alkyl, C 1- C 6 Hydroxyalkyl, C 1- C 6 Aminoalkyl, C 2- C 6 Alkenyl, and C 2- C 6 alkynyl; Each R a is independent, C 1- C 6 Alkyl, C 1- C 6 Haloalkyl, C 1- C 6 Deuterated alkyl, C 1- C 6 Hydroxyalkyl, C 1- C 6 Aminoalkyl, C 2- C 6 Alkenyl, C 2- C 6 is selected from the group consisting of alkynyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl; wherein each of alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl independently represents one or more of oxo, deuterium, halogen, -CN, -OH, -OMe, -NH 2 , -C(=O)Me, -C(=O)OH, -C(=O)OMe, C 1- C 6 Alkyl, or C 1- C 6 optionally substituted with haloalkyl; Each R b are independently hydrogen, C 1- C 6 Alkyl, C 1- C 6 Haloalkyl, C 1- C 6 Deuterated alkyl, C 1- C 6 Hydroxyalkyl, C 1- C 6 Aminoalkyl, C 2- C 6 Alkenyl, C 2- C 6 is selected from the group consisting of alkynyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl; wherein each of alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl independently represents one or more of oxo, deuterium, halogen, -CN, -OH, -OMe, -NH 2 , -C(=O)Me, -C(=O)OH, -C(=O)OMe, C 1- C 6 Alkyl, or C 1- C 6 optionally substituted with haloalkyl; Each R c and R d are independently hydrogen, C 1- C 6 Alkyl, C 1- C 6 Haloalkyl, C 1- C 6 Deuterated alkyl, C 1- C 6 Hydroxyalkyl, C 1- C 6 Aminoalkyl, C 2- C 6 Alkenyl, C 2- C 6 and wherein each of alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl is independently selected from the group consisting of one or more of oxo, deuterium, halogen, -CN, -OH, -OMe, -NH 2 , -C(=O)Me, -C(=O)OH, -C(=O)OMe, C 1- C 6 Alkyl, or C 1- C 6 optionally substituted with haloalkyl; or R c and R d together with the nitrogen atom to which they are attached, one or more of oxo, deuterium, halogen, -CN, -OH, -OMe, -NH 2 , -C(=O)Me, -C(=O)OH, -C(=O)OMe, C 1- C 6 Alkyl, or C 1- C 6 Compounds that form heterocycloalkyl optionally substituted with haloalkyl.

12. 12. A compound according to claim 11, or a pharma- ceutically acceptable salt thereof, Each R A are independently deuterium, halogen, C 1- C 6 Alkyl, C 1- C 6 Haloalkyl, or C 1- C 6 A compound which is a deuterated alkyl.

13. 13. A compound according to claim 11 or 12, or a pharma- ceutically acceptable salt thereof, R 4 is hydrogen or -OR b A compound.

14. A compound according to any one of claims 11 to 13, or a pharma- ceutically acceptable salt thereof, R 3 A compound in which is hydrogen.

15. A compound according to any one of claims 11 to 14, or a pharma- ceutically acceptable salt thereof, R 5 But -NR 8 C(=O)NR 9 R 10 A compound.

16. A compound according to any one of claims 11 to 15, or a pharma- ceutically acceptable salt thereof, R 9 and R 10 together with the nitrogen atom to which they are attached, one or more of oxo, deuterium, halogen, -CN, -OH, -OMe, -NH 2 , -C(=O)Me, -C(=O)OH, -C(=O)OMe, C 1- C 6 Alkyl, or C 1- C 6 Compounds that form heterocycloalkyl optionally substituted with haloalkyl.

17. A compound according to any one of claims 11 to 14, or a pharma- ceutically acceptable salt, stereoisomer or solvate thereof, R 5 But -NR 8 C(=O)R 7 A compound.

18. A compound according to any one of claims 11 to 14 or 17, or a pharma- ceutically acceptable salt, stereoisomer or solvate thereof, R 7 but one or more of oxo, deuterium, halogen, -CN, -OH, -OMe, -NH 2 , -C(=O)Me, -C(=O)OH, -C(=O)OMe, C 1 -C 6 Alkyl, or C 1 -C 6 A compound which is a cycloalkyl optionally substituted with a haloalkyl.

19. A compound represented by the formula 【Chemistry 15-1】 【Chemistry 15-2】 【Chemistry 15-3】 【Chemistry 15-4】 1. A compound selected from the group consisting of:

20. A compound represented by the formula 【Chemistry 16-1】 【Chemistry 16-2】 【Chemistry 16-3】 【Chemistry 16-4】 1. A compound selected from the group consisting of:

21. 21. A pharmaceutical composition comprising a therapeutically effective amount of a compound according to any one of claims 1 to 20 or a pharma- ceutically acceptable salt, stereoisomer or solvate thereof, and a pharma- ceutically acceptable excipient.

22. A pharmaceutical composition comprising a compound according to any one of claims 1 to 20, or a pharma- ceutical acceptable salt thereof, for inhibiting the TYK2 enzyme in a patient or biological sample, comprising contacting said patient or biological sample with a compound according to any one of claims 1 to 20, or a pharma- ceutical acceptable salt thereof.

23. 21. A pharmaceutical composition comprising a compound according to any one of claims 1 to 20 or a pharma- ceutically acceptable salt thereof for treating an autoimmune, inflammatory, proliferative, endocrine or neurological disorder, comprising administering to a patient in need thereof a compound according to any one of claims 1 to 20, or a pharma- ceutically acceptable salt, stereoisomer or solvate thereof.

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