How to detect the degree of resilience

Abstract

To provide a novel method, etc. for detecting a degree of resilience adapted to a subject (for example, a Japanese) placed under environment where relationship with the society is emphasized more than in Europe and United Stages.SOLUTION: A method, etc. according to the present invention for detecting a degree of resilience for a subject, the method, etc. include the steps of: allowing a subject to select and answer, for presented batches of questions, at least one of graded choices; scoring the answers; and detecting the degree of resilience according to scores and / or measurement information of the autonomic nervous function. The presented batches of questions include at least one question belonging to the eternal soul, at least one question belonging to the mind, at least one question belonging to the intent, at least one question belonging to the corporeal soul, at least one question belonging to the will and at least one question belonging to the society.SELECTED DRAWING: Figure 1

Description

[Technical field]

[0001] The present invention relates to a method for detecting a degree of resilience. [Background technology]

[0002] In recent years, resilience has been a concept that has attracted a lot of attention, and many studies on resilience have been published. Resilience began to be introduced in the 1980s as a concept that means a defensive factor and resistance against mental illness caused by stress, etc., and is now often used to mean "the ability to bounce back from adversity" (Non-Patent Document 1). In the field of psychiatry, it has already been reported that there is a negative correlation between resilience and the onset of depression (Non-Patent Document 2), and that improving resilience has an inhibitory effect on the onset of depression (Non-Patent Document 3), and it is said that improving resilience is necessary to maintain mental health. In other words, resilience is also attracting attention from the perspective of preventive medicine. In addition, a correlation between QOL and resilience during the course of physical illnesses such as chronic heart disease (CVD), cancer patients (Non-Patent Document 4), and neurodegenerative diseases (Non-Patent Document 5) has begun to be reported. It has also been reported that in a large-scale observational study of healthy women, resilience is associated with lifestyle habits such as diet, exercise, and sleep, which are considered to be risk factors for cardiovascular disease (CVD) (Non-Patent Document 6), and that exercise and dietary habits improve resilience (Non-Patent Document 7, Non-Patent Document 8). In other words, the importance of resilience has been noted not only in the field of psychiatry, but also in the prevention and treatment of physical illnesses, and it has been suggested that lifestyle habits are involved in maintaining resilience.

[0003] To scientifically verify and study resilience, a scale that quantitatively measures resilience is necessary, and thus several scales have been developed to date. Among them, Wagnild & Young's Resilience Scale (RS) is considered to be one of the most reliable and valid in the West. The Japanese version was created by Nishi Daisuke et al. (Non-Patent Document 9), and the Japanese version of the RS25 is often used in resilience research in Japan. However, when Nishi et al. actually verified this Japanese version of the RS25 in Japanese people, the average total score was significantly lower than the original, the opposite result to the English version was obtained, that is, the higher the stress received, the higher the resilience, and the correlation between depression and resilience was low. In these respects, the reliability and validity of the Japanese version is not as good as that of the original, and it is pointed out in the paper by Nishi et al. that the scale is not necessarily suitable for Japanese people. It is speculated that this may be due to the tendency of Japanese people to refrain from expressing themselves positively and proactively. It has also been mentioned that there was a bias, such as the fact that most of the subjects used in the verification were students and young women.

[0004] [ka]

[0005] On the other hand, scales developed in Japan include the "Mental Resilience Scale" by Shinji Oshio et al. (Non-Patent Document 10) and the "Two-Dimensional Resilience Factor Scale" by Mari Hirano et al. (Non-Patent Document 11). However, both have been verified on students, and their validity has only been shown for younger people. Therefore, developing a versatile resilience scale suitable for Japanese people is considered to be an important issue for both effectively intervening in the prevention and recovery of mental illness and for developing empirical research on resilience. [Prior art documents] [Non-patent literature]

[0006] [Non-Patent Document 1] Nishi et al., Japanese Journal of General Hospital Psychiatry, General Hospital Psychiatry, 2012, 24, 2-8 [Non-Patent Document 2] Lavretsky et al., Aging Health (2007) 3(3), 309-323 [Non-Patent Document 3] Julia CP et al., Child Abuse Negl. 64 (2017) 89-100 [Non-Patent Document 4] Joao Paulo et al., BMC Palliat Care (2016) 15:70 [Non-Patent Document 5] Andrea M et al. J Health Psychol., 2016 3004-3015 [Non-Patent Document 6] Springfield S et al.,Nutrients. 2020; 12(7):2107 [Non-Patent Document 7] Ho FK et al.,BMC pediatrics 2015;15:48 [Non-Patent Document 8] Hattori et al., Tokai Gakuen University Research Bulletin. 2014;19:91-101 [Non-Patent Document 9] Nishi D, et al., BMC Res Notes. 2010, 3: 310 [Non-Patent Document 10] Oshio, S.; Nakatani, M.; Kaneko, K.; Nagamine, S. Psychological characteristics that lead to recovery from negative events: Creation of a scale for psychological resilience. Counseling Research 2002, Vol. 35, No. 1, 57-65. [Non-Patent Document 11] Hirano, M. Classification of resilience trait and acquired factors: Creation of a two-dimensional resilience factor scale (BRS). Personality Research 2010, Vol. 19, No. 2, 94-106 Summary of the Invention [Problem to be solved by the invention]

[0007] The present invention aims to provide a new method for detecting the degree of resilience suitable for subjects (e.g., Japanese people) who live in an environment where relationships with society are given more importance than in Europe and the United States. [Means for solving the problem]

[0008] Hagiwara, the creator of this invention, has considered the therapeutic effects of Kampo medicine and has proposed the idea that Kampo medicine has medicinal effects by enhancing the resilience of the mind and body (Keisuke Hagiwara. Kampo Guides the Resilience of the Mind and Body, Osaka University Press). In Oriental medicine, there is a concept of the five organs consisting of the liver, heart, spleen, lungs, and kidneys. This concept is different from the concept of organs in modern medicine, and is a system concept in which functions across organs are clustered. Specifically, the liver does not refer to the liver, but to the system of physical control in which the endocrine and metabolic systems are added to the autonomic nervous system. The heart refers to the system of physical control by the circulatory system and central nervous system, the spleen refers to the system of physical control by the digestive system, the lungs refer to the system of physical control by the respiratory system, and the kidneys refer to the system of physical control in which vital energy is added to the urinary and reproductive system. In addition, Oriental medicine evaluates the body and mind as one without distinguishing them, based on the idea of ​​the unity of the mind and body. The concept of the five organs includes human emotions, known as the five feelings, and higher mental functions, known as the five organs. In the "Five Desires", human emotions are clustered as follows: Liver = anger, Heart = joy, Spleen = worry, Lung = sadness, Kidney = fear. In the "Five Treasures", human higher mental functions are clustered as follows: Liver = soul (decisiveness), Heart = spirit (cognitive function), Spleen = will (memory), Lung = spirit (motivation), Kidney = will (willpower). In this way, the five viscera (heart, spleen, lungs, kidneys, liver) and emotions are said to be interrelated, and the Japanese Resilience Scale (J-RS: Figure 1) used in this invention is based on this Oriental medicine perspective, and further includes content that is in line with the temperament of Japanese people, such as empathy, which is not emphasized in existing scales, and is devised with consideration of the expression methods that are cited as shortcomings of existing scales.

[0009] The present inventors have investigated an evaluation method suitable for evaluating the resilience of subjects (e.g., Japanese) in an environment where relationships with society are more important than in the West, and have found that (1) questions related to the five organs of Oriental medicine, namely "liver," "heart," "spleen," "lungs," and "kidneys," as well as questions related to sociality, and answers to these questions, and (2) measurement information on the subject's autonomic nervous function, are highly correlated with the degree of resilience and can be used as markers for detecting the degree of resilience. More specifically, they have found that a method for detecting the degree of resilience based on either or both of (1) questions related to the "five emotions" of Oriental medicine, that is, the five emotions of anger, joy, thought, sorrow, and fear, and "willpower," which is closely related to resilience among the "five organs," as well as questions related to sociality, and answers to these questions, and (2) measurement information on the subject's autonomic nervous function, is suitable for subjects such as Japanese. The present invention has been completed based on these findings. Note that "fear" of the five emotions and "willpower" of the five organs are both included in the "kidneys" of the five organs concept.

[0010] The present invention typically includes the following aspects. Section 1. 1. A method for detecting a degree of resilience in a subject, comprising: A step in which the subject answers the presented questions by selecting at least one answer from the graded options; Scoring the answers; and A process to detect the degree of resilience based on the score Including, The presented questions include at least one question belonging to the liver, at least one question belonging to the heart, at least one question belonging to the spleen, at least one question belonging to the lungs, at least one question belonging to the kidneys, and at least one question belonging to society. method. Section 2. At least one question belonging to the main point is, "I can control my emotions in stressful situations" "I get annoyed when things don't go the way I want them to." "I can remain calm even in difficult situations" and "When something inconvenient happens to me, I suddenly explode with emotion." A question corresponding to at least one question selected from the group consisting of: At least one question in mind: "I can honestly be happy about my success." "I can forgive others even if I have suffered a disadvantage" "I can trust people even when they treat me dishonestly," and "Even when things are tough, I can still enjoy my daily life" A question corresponding to at least one question selected from the group consisting of: At least one question belonging to the spleen, "Don't dwell on things that are over." "Even if you fail, you can change your mindset." "When things go wrong, I become pessimistic"; and "Even the smallest things make me feel down" A question corresponding to at least one question selected from the group consisting of: At least one question belonging to the lungs, "I'm worried about how I'm being evaluated and what other people think." "I'm bothered by small things that no one else notices," "When I'm in an uneasy situation, I feel agitated," and "I feel alone when I'm facing or dealing with difficult things." A question corresponding to at least one question selected from the group consisting of: At least one question related to the kidney, "I can overcome failure and take on new challenges." "Even when faced with difficult situations, I can look at things in a positive way." "Even if you fail, you can have another goal," and "Even if I'm feeling anxious, I can still believe in myself" A question corresponding to at least one question selected from the group consisting of: At least one question belonging to said society, "Someone to laugh and cry with" "There's someone I can have fun with" "There is someone who is there for me and watches over me." "There are people who care about me and say kind words to me," and "There are people who are kind to me" A question corresponding to at least one question selected from the group consisting of: The method according to item 1. Section 3. Item 3. The method according to item 1 or 2, wherein the graded options are five graded options. Section 4. Item 4. The method according to item 3, wherein the five options correspond to: very applicable, fairly applicable, neither, not very applicable, and not applicable at all, respectively. Section 5. 1. A method for detecting a degree of resilience in a subject, comprising: Detecting the degree of resilience according to measurement information of the subject's autonomic nervous function A method comprising: Section 6. 1. A method for detecting a degree of resilience in a subject, comprising: A step in which the subject answers the presented questions by selecting at least one answer from the graded options; scoring the answers; and Detecting the degree of resilience based on the score and the measurement information of the subject's autonomic nervous function Including, The presented group of questions includes at least one question belonging to anger, at least one question belonging to joy, at least one question belonging to thought, at least one question belonging to sadness, at least one question belonging to fear, and at least one question belonging to society; method. Section 7. Item 7. The method according to item 5 or 6, wherein the autonomic nervous function is parasympathetic nervous activity. Section 8. A method in which the degree of resilience obtained by the method according to any one of items 1 to 7 is used as a marker for detecting susceptibility to mood disorders or postpartum mental disorders. Effect of the Invention

[0011] According to the present invention, a new method can be provided for detecting the degree of resilience correlated with the Japanese version of RS25, the depression scale (CES-D), self-esteem (RSES), autonomic nervous function, etc. This makes it possible to detect susceptibility to diseases belonging to mood disorders or postpartum mental disorders. [Brief description of the drawings]

[0012] [Figure 1] The questions used in Example 1 are shown below. These questions are examples of questions that can be used in the method for detecting resilience of the present invention. [Diagram 2] 1 is a graph showing the correlation between the resilience scale using the J-RS obtained in Example 1 and the resilience scale using the Japanese version of the RS25. [Diagram 3] 1 is a graph showing the correlation between the resilience scale by J-RS obtained in Example 1 and self-esteem (RSES). [Figure 4] 1 is a graph showing the correlation between the resilience scale by J-RS and the depression scale (CES-D) obtained in Example 1. [Diagram 5] 1 is a graph showing the correlation between the resilience scale by J-RS obtained in Example 1 and parasympathetic nervous function. [Figure 6]This is a graph showing the correlation between the resilience scale using the J-RS and the Geriatric Depression Scale Short Version - Japanese (GDS-SJ). DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS

[0013] As used herein, a subject refers to a human being who is the subject of a test. In this specification, the degree of resilience may be referred to as the resilience scale.

[0014] One aspect of the present invention relates to a method for detecting the degree of resilience in a subject, and a method for using the degree of resilience detected by the method as a marker for detecting susceptibility to a mood disorder or a postpartum mental disorder. The method for detecting the degree of resilience in a subject includes (1) a method using the subject's answers to questions, (2) a method using the results of measurements of the subject's autonomic nervous function (particularly the parasympathetic nervous function), and (3) a method using both the subject's answers to questions and the results of measurements of the subject's autonomic nervous function (particularly the parasympathetic nervous function).

[0015] In the method for detecting the degree of resilience in a subject, the subject is not particularly limited, but preferred subjects include Japanese people, postpartum women (e.g., within one year of giving birth, preferably within six months of giving birth), elderly people (e.g., 60 years or older, preferably 65 years or older), etc.

[0016] (Method 1 to detect the degree of resilience) The method for detecting the degree of resilience of a subject using the subject's answers to questions includes a step (answering step) in which the subject selects at least one answer from graded options for a group of questions presented to the subject, a step (scoring step) of scoring the answers, and a step (detecting step) of detecting the degree of resilience according to the scores, the group of questions presented to the subject including at least one question pertaining to the liver, at least one question pertaining to the heart, at least one question pertaining to the spleen, at least one question pertaining to the lungs, at least one question pertaining to the kidneys, and at least one question pertaining to the society. The questions and answers may be written on paper or displayed on a display device capable of displaying characters.

[0017] Here, the liver, heart, spleen, lungs, and kidneys are five categories of human emotions and higher mental functions according to the concepts of the "Five Wills" and "Five Treasures" in Oriental medicine (Huangdi Neijing, "Su Wen," Xuanming Wu Qi Chapter, 23, Chapter 10). For example, the concept of the kidneys is related to fear in the "Five Wills," and at the same time, it is related to will (willpower) in the "Five Treasures," so questions about "fear" or "willpower" are included in the group of questions that belong to the kidneys. Therefore, whether a question pertains to the liver, heart, spleen, lungs, or kidneys is determined based on the "five feelings" and the "five organs." The key questions are those related to the subject's anger or emotional control. The mind questions are questions that concern the subject's pleasure or cognitive functions (understanding, judgment, logic, etc.). The questions in this category are questions that relate to the subject's tendencies to brood or trauma. The pulmonary questions are questions relating to the subject's sadness or anxiety. The kidney questions are questions that concern the subject's fear or willpower.

[0018] The questions relating to society are questions about the sociality of the subject, such as questions about the subject's relationship with society, and the subject's connections and empathy with others.

[0019] At least one of each of these six categories of questions (questions belonging to the liver, heart, spleen, lungs, kidneys, and society) is included in the question group. The number of questions per category can be 2 or more, 2-20, 2-10, 2-6, 3-6, etc. The number of questions in one category may be the same as or different from the number of questions in the other categories.

[0020] The number of questions constituting the question group should be one or more per category, i.e., six or more, and can be 6 to 120, 12 to 60, 12 to 36, 18 to 36, etc.

[0021] Examples of questions related to the liver (controlling anger and emotions) include "I can control my emotions in stressful situations," "I get irritated when things don't go my way," "I can remain calm even in difficult situations," and "I suddenly explode with emotion when something inconvenient happens."

[0022] Examples of questions relating to the mind (joy and cognitive functions) include "I can be genuinely happy about my successes," "I can forgive others even when I have suffered a disadvantage," "I can trust people even when they have treated me dishonestly," and "I can enjoy my daily life even when there are difficult times."

[0023] Examples of questions relating to the spleen (tendency to ruminate and trauma) include "I don't dwell on things that are over," "Even if I fail, I can move on," "When something goes wrong, I tend to see things pessimistically," and "Even small things make me feel down."

[0024] Examples of questions related to the lungs (sadness and anxiety) include, "I worry about how others perceive me," "I worry about small things that no one else seems to notice," "When I'm in an uneasy situation, I feel restless," and "When I'm facing or dealing with difficult situations, I feel lonely."

[0025] Examples of questions relating to the kidneys (fear and will) include "I can overcome failure and take on new challenges," "Even when faced with difficult situations, I can look at things in a positive way," "Even when I fail, I can set another goal," and "Even when I feel anxious, I can believe in myself."

[0026] Examples of questions relating to society include "There are people who laugh and cry with me," "There are people I can have fun with," "There are people who are close to me and watch over me," "There are people who care about me and say kind words to me," and "There are people who are sympathetic to me."

[0027] The questions are not limited to the ones specifically shown above, and may be questions of a content equivalent to the ones specifically shown above.

[0028] In this specification, the specifically illustrated set of 25 questions, or the method of detecting the degree of resilience using this set of questions, may be referred to as J-RS.

[0029] In addition to the questions, subjects are presented with graded options as answers to the questions, and are asked to select an answer from the options. Here, the answer options are graded according to the degree to which the questions apply, and may be, for example, five levels such as "very applicable," "somewhat applicable," "neither," "not really applicable," and "not applicable at all," or options equivalent to these.

[0030] Answer options can be on a 3-6 scale, with 3-5 scales being preferred.

[0031] The answer options are not limited to the ones specifically shown above. The answer options may be ones that are equivalent to the ones specifically shown above.

[0032] The answers of the subjects are scored. For example, in the case of the J-RS used in the embodiment, the answer options selected by the subjects are scored as follows. Note that the scoring in the present invention is not limited to this example of scoring. 5 points: "Applies well" 4 points: "Well, I'm hooked." 3 points: "Neither" 2 points: "Not very applicable" 1 point: "Not at all applicable"

[0033] In this scoring system, the more the content of each question in the J-RS corresponds to the higher the level of resilience, so if the total score obtained for each answer is high, the level of resilience is detected as high, and if it is low, the level of resilience is detected as low. If the content of one or more questions that make up the question group corresponds to a higher level of resilience, the answer options for that question can be scored in the opposite way to the above.

[0034] The J-RS consists of 25 questions, so the total score ranges from 25 to 125 points. Subjects who score 25 points have the lowest resilience, and subjects who score 125 points have the highest resilience. In this way, the J-RS allows the level of resilience to be evaluated according to the total score (25 to 125 points).

[0035] In addition, when scoring answers, weighting may be applied according to the content of the question. For example, questions that are more important in the resilience assessment compared to other questions may be assigned a score by multiplying the base score (1, 2, 3, 4, and 5 points for the J-RS) by an appropriate coefficient greater than 1 (e.g., 1.1, 1.2, 1.3, 1.4, 1.5, etc.), and questions that are less important may be assigned a score by multiplying the base score by an appropriate coefficient less than 1 (e.g., 0.5, 0.6, 0.7, 0.8, 0.9, etc.).

[0036] (Method 2 to detect the degree of resilience) A method of utilizing the measurement results of the subject's autonomic nervous function includes a step of detecting a degree of resilience in response to the measurement information of the subject's autonomic nervous function.

[0037] Here, the measurement result is not particularly limited as long as it is a result of measurement that can measure the level of autonomic nervous function, but is preferably a result of measurement that can measure the level of parasympathetic nervous function. It is preferable that the subject whose parasympathetic nervous function is measured is in a normal state. Examples of the measurement results include, but are not limited to, heartbeat intervals, time series data of heartbeat intervals, heart rate, indices of sympathetic nervous function (LF / HF, CSI, etc.), indices of parasympathetic nervous function (HF, RMSSD, NN50, CVI, etc.), overall activity of heart rate fluctuations (LF, SDNN, etc.), etc. Also, one type of measurement result may be used, or two or more types may be used in combination.

[0038] For example, if parasympathetic nervous function in a normal state is high, resilience can be evaluated as being high, and if parasympathetic nervous function in a normal state is low, resilience can be evaluated as being low.

[0039] (Method 3 of detecting resilience) The method utilizing both the subject's answers to the questions and the measurement results of the subject's autonomic nervous function includes a step (answering step) in which the subject selects at least one answer from a graded option set for a group of questions presented to them, a step (scoring step) of scoring the answer, and a step (detecting step) of detecting the degree of resilience based on the score and the measurement information of the subject's autonomic nervous function, the group of questions presented to them including at least one question relating to the liver, at least one question relating to the heart, at least one question relating to the spleen, at least one question relating to the lungs, at least one question relating to the kidneys, and at least one question relating to society.

[0040] The answering process and the scoring process in this method are the same as those in method 1, and the measurement information of the autonomic nerve function is the same as those in method 2.

[0041] In the detection step, the degree of resilience is determined from the score obtained in the scoring step and the measurement information of autonomic nervous function (preferably parasympathetic nervous function). For example, the higher the score on the Resilience Scale (J-RS) or the higher the normal parasympathetic nervous function, the higher the resilience is expected to be. If the two sets of data are dissociated, it is possible to find the true resilience by searching for the cause. Also, if both are low, it is possible to move in the direction of increasing resilience by considering an intervention method for the subject.

[0042] (Method of using the degree of resilience as a marker for detecting susceptibility to mood disorders or postpartum mental disorders) The degree of resilience obtained by any of the methods 1 to 3 may be correlated with the RS25 Japanese version, the CES-D depression scale, the RSES self-esteem scale, and the Geriatric Depression Scale Short Version (GDS-SJ). Therefore, the degree of resilience can be used as a marker for detecting susceptibility to mood disorders or postpartum mental disorders.

[0043] For example, by taking into consideration that a score of 16 or higher on the existing CES-D scale indicates a depressed state, and a score of 6 or higher on the Geriatric Depression Scale Short Version - Japanese (GDS-SJ) indicates a depressive tendency, the cutoff value for the J-RS in the embodiment is derived to be 60.4 points from the correlation with the CES-D for postpartum women, and 62.0 points from the correlation with the GDS-SJ for the elderly, making it possible to predict a depressive tendency from the resilience scale.

[0044] Mood disorders include bipolar disorder, recurrent depressive disorder, persistent mood disorder, depressive disorder (depression, persistent depressive disorder, etc.), and post-traumatic stress disorder (also known as PTSD).

[0045] Postpartum mental disorders include, for example, postpartum depression, mania, bipolar disorder, and the like.

[0046] The present invention is a groundbreaking invention that allows easy evaluation of individual differences in depression tendency and stress resistance by combining a resilience scale and an autonomic nervous function evaluation. The present invention can also be introduced into group testing in companies and schools, and if this new detection method (evaluation method) can predict future declines in mental health, it will be useful for early intervention and maintaining the mental health of society as a whole. In addition, the method of the present invention allows for stable evaluation, making it possible to consider effective intervention methods and contribute to medical economics. In addition, in the IT industry and AI, which have grown significantly in recent years, it will be possible to develop apps and software for this method.

[0047] Those skilled in the art can refer to the above description, particularly the description regarding J-RS, and appropriately modify the embodiments while maintaining the principles thereof, and such modified embodiments are encompassed by the present invention. EXAMPLES

[0048] Hereinafter, one embodiment of the present invention will be described in more detail with reference to examples, but the present invention is not limited to these.

[0049] Example 1 Relationship between a new resilience test (J-RS) and mental status in postpartum women (method) A questionnaire was created that included perspectives unique to Japanese people and also took into consideration the way of expression (Figure 1). First, from the perspective of "unique to Japanese people," the questionnaire included four questions about each of the five emotions (five emotions) and mental activities (five organs) (anger; joy; thought; sadness; fear and will) based on the ideas of the ancient Chinese medicine text "Huangdi Neijing." In addition to these questions, the questionnaire also included five questions from the perspective of social connections. The subjects were Japanese women (27 people, average age 33.63 years, range 27-41 years) who had given birth within six months. It is said that the onset of postpartum depression is common within six months of giving birth. This questionnaire was presented to the subjects and responses were collected (J-RS). The J-RS questionnaire presented each question with a five-level response option (strongly applies, somewhat applies, neither, does not apply very much, and does not apply at all), and respondents answered by selecting one option. The responses were scored according to the following criteria: 5 points: "Applies well" 4 points: "Well, I'm hooked." 3 points: "Neither" 2 points: "Not very applicable" 1 point: "Not at all applicable" The J-RS consists of 25 questions, so the total score ranges from 25 to 125 points. Subjects with a high total score were evaluated as having high resilience, and subjects with a low total score were evaluated as having low resilience. In this way, the J-RS was able to detect the degree of resilience (resilience scale) of each subject based on the total score (25 to 125 points).

[0050] In addition to the J-RS, the same subjects were administered the Japanese version of the RS25, the Depression Scale (CES-D) (LS Radloff, Applied Psychological Measurement. 1977;1:385-401), and the Self-Esteem Scale (RSES) (Rosenberg, M. Prinston University Press. 1965), and the correlations between these scales and the J-RS were examined.

[0051] (result) A positive correlation was found between the J-RS and the Japanese version of the RS25 (Figure 2), and between the J-RS and the Self-Esteem Scale (RSES) (Figure 3) (r=0.74, p<0.0001 and r=0.70, p<0.0001, respectively). On the other hand, a stronger negative correlation (r=-0.52, p=0.01) was found between the J-RS and the Depression Scale (CES-D) (Figure 4) than the negative correlation (r=-0.30) between the Japanese version of the RS25 and the CES-D. These results indicate that the resilience scale derived from the J-RS is valid as an index of resilience assessment, and is more appropriate than the Japanese version of the RS25.

[0052] (Example 2) Relationship between a new method for detecting the degree of resilience (J-RS) and autonomic nervous function in postpartum women (method) The subjects were 27 Japanese women within six months of giving birth, as in Example 1. Four phases (normal state (mother and child were free to move about), standing with infant held, mother and child separated, standing with infant held) were set, and the electrocardiograms of the mother and child were measured for three minutes in each phase using Polymate mini (Miyuki Giken). Time series data of heart rate intervals was extracted from the data for the last minute of each phase, and sympathetic and parasympathetic functions were evaluated using a method of evaluation using Lorenz plots (Toichi et al., 1997) (analysis software: Map1060).

[0053] (result) A significant positive correlation was observed between parasympathetic function (parasympathetic activity in a normal state) and the J-RS obtained in Example 1 (r=0.42, p=0.05: FIG. 5). This result and the results of Example 1 suggest that resilience can be predicted from the measurement results of parasympathetic function in a normal state.

[0054] (Example 3) Relationship between the new method for detecting the degree of resilience in elderly people (J-RS) and the Geriatric Depression Scale Short Version - Japanese version (GDS-SJ) (method) The subjects were 255 Japanese elderly people (average age 75.8 years old), and the resilience scale (J-RS) was derived for each subject in the same manner as in Example 1. In addition to the J-RS, the same subjects were also measured using the Geriatric Depression Scale-Short Version (GDS-SJ) (Sheikh JI et al. Clin Geron.1986;5:165-173,Sugishita M et al. Japanese Journal of Cognitive Neuroscience 2009;11:87-90) and correlations with the J-RS were examined.

[0055] (result) A negative correlation was found between the J-RS and the Geriatric Depression Scale (Figure 6; r = -0.40, p < 0.001). These results indicate that the resilience scale derived from the J-RS is valid as an index of resilience assessment even in the elderly.

Claims

1. A method for scoring a degree of resilience in a subject to detect the degree of resilience in the subject, comprising: A step in which the subject answers the presented questions by selecting at least one answer from the graded options; and The process of scoring answers Including, The presented set of questions includes at least two questions related to the liver (anger and emotion control), at least two questions related to the heart (joy and cognitive functions), at least two questions related to the spleen (tendency to brood and trauma), at least two questions related to the lungs (sadness and anxiety), at least two questions related to the kidneys (fear and will), and at least two questions related to the sociality of the subject related to society.

1. A method comprising: At least two questions belonging to the main question are: "I can control my emotions in stressful situations" "I get annoyed when things don't go the way I want them to." "I can remain calm even in difficult situations" and "When something inconvenient happens to me, I suddenly explode with emotion." questions corresponding to at least two questions selected from the group consisting of: At least two questions in the mind: "I can honestly be happy about my success." "I can forgive others even if I have suffered a disadvantage" "I can trust people even when they treat me dishonestly," and "Even when things are tough, I can still enjoy my daily life" questions corresponding to at least two questions selected from the group consisting of: At least two questions belonging to the spleen, "Don't dwell on things that are over." "Even if you fail, you can change your mindset." "When things go wrong, I become pessimistic"; and "Even the smallest things make me feel down" questions corresponding to at least two questions selected from the group consisting of: At least two questions belonging to the lungs, "I'm worried about how I'm being evaluated and what other people think." "I'm bothered by small things that no one else notices," "When I'm in an uneasy situation, I feel agitated," and "I feel alone when I'm facing or dealing with difficult things." questions corresponding to at least two questions selected from the group consisting of: At least two questions related to the kidney: "I can overcome failure and take on new challenges." "Even when faced with difficult situations, I can look at things in a positive way." "Even if you fail, you can have another goal," and "Even if I'm feeling anxious, I can still believe in myself" questions corresponding to at least two questions selected from the group consisting of: Questions regarding the sociality of at least two subjects belonging to said society, "Someone to laugh and cry with" "There's someone I can have fun with" "There is someone who is there for me and watches over me." "There are people who care about me and say kind words to me," and "There are people who are kind to me" A question corresponding to at least two questions selected from the group consisting of: method.

2. The method of claim 1 , wherein the graded options are five-level options.

3. 3. The method of claim 2, wherein the five options correspond to: very applicable, fairly applicable, neutral, not very applicable, and not applicable at all, respectively.

4. A method for scoring a degree of resilience in a subject in order to detect the degree of resilience in the subject according to measurement information of the subject's autonomic nervous function, comprising: A step in which the subject answers the presented questions by selecting at least one answer from the graded options; and The process of scoring answers Including, The presented set of questions includes at least two questions related to the liver (anger and emotion control), at least two questions related to the heart (joy and cognitive functions), at least two questions related to the spleen (tendency to brood and trauma), at least two questions related to the lungs (sadness and anxiety), at least two questions related to the kidneys (fear and will), and at least two questions related to the sociality of the subject related to society.

1. A method comprising: At least two questions belonging to the main question are: "I can control my emotions in stressful situations" "I get annoyed when things don't go the way I want them to." "I can remain calm even in difficult situations" and "When something inconvenient happens to me, I suddenly explode with emotion." questions corresponding to at least two questions selected from the group consisting of: At least two questions in the mind: "I can honestly be happy about my success." "I can forgive others even if I have suffered a disadvantage" "I can trust people even when they treat me dishonestly," and "Even when things are tough, I can still enjoy my daily life" questions corresponding to at least two questions selected from the group consisting of: At least two questions belonging to the spleen, "Don't dwell on things that are over." "Even if you fail, you can change your mindset." "When things go wrong, I become pessimistic"; and "Even the smallest things make me feel down" questions corresponding to at least two questions selected from the group consisting of: At least two questions belonging to the lungs, "I'm worried about how I'm being evaluated and what other people think." "I'm bothered by small things that no one else notices," "When I'm in an uneasy situation, I feel agitated," and "I feel alone when I'm facing or dealing with difficult things." questions corresponding to at least two questions selected from the group consisting of: At least two questions related to the kidney: "I can overcome failure and take on new challenges." "Even when faced with difficult situations, I can look at things in a positive way." "Even if you fail, you can have another goal," and "Even if I'm feeling anxious, I can still believe in myself" questions corresponding to at least two questions selected from the group consisting of: Questions regarding the sociality of at least two subjects belonging to said society, "Someone to laugh and cry with" "There's someone I can have fun with" "There is someone who is there for me and watches over me." "There are people who care about me and say kind words to me," and "There are people who are kind to me" A question corresponding to at least two questions selected from the group consisting of: method.

5. The method of claim 4, wherein the autonomic function is parasympathetic activity.

6. A method for using the degree of resilience obtained by the method according to any one of claims 1 to 5 as a marker for detecting susceptibility to a mood disorder or a postpartum psychiatric disorder.

Images