Cosmetics

Abstract

[Problem] To provide a cosmetic that achieves both a high wrinkle-improving effect as well as low irritation. [Solution] A cosmetic according to the present invention includes retinol and an organic acid represented by general formula (I) below: (In formula (I), "n" represents an integer of 2-5) or a salt thereof. The cosmetic may further include vitamin C as necessary.

Description

[Technical field]

[0001] The present invention relates to a cosmetic preparation that can provide a sufficient wrinkle improving effect while suppressing the sensation of irritation. [Background technology]

[0002] Anti-aging is one of the major goals of skincare cosmetics, and wrinkles are the skin aging phenomenon that has received the most attention from the cosmetic point of view. In recent years, retinol and other substances have attracted attention as cosmetic drugs that have the effect of improving skin wrinkles, and the application of retinol (vitamin A) and retinoic acid, which are types of retinoids, to skin cosmetics has been considered. These substances act on keratinocytes to promote the synthesis of hyaluronic acid, and are known to have an effect of improving wrinkles by increasing the moisture content of the stratum corneum. In particular, retinol is excellent as a cosmetic drug because its effect is milder than that of retinoic acid and does not show strong side effects. However, retinol and its derivatives are known to be irritating to the skin when applied to the skin. Therefore, even when retinol or its derivatives are blended into cosmetics, the amount of retinol or its derivatives cannot be increased, making it difficult to impart a sufficient wrinkle improvement effect. [Prior art documents] [Patent documents]

[0003] [Patent Document 1] Patent No. 4865251 Specification Summary of the Invention [Problem to be solved by the invention]

[0004] In order to solve the above problems, there has been a need for the development of a technology that can suppress the irritation felt by the skin even when a large amount of retinol is blended in a cosmetic composition. [Means for solving the problem]

[0005] According to the present invention, the following inventions are provided. [1] (A) retinol, and (B) the following general formula (I): [ka] (In formula (I), n represents an integer of 2 to 5.) An organic acid represented by the formula: A cosmetic comprising: [2] The cosmetic according to [1], wherein the blending amount of the retinol is 0.01 to 0.5 mass % based on the total mass of the cosmetic. [3] The cosmetic according to [1] or [2], wherein the blending amount of the organic acid or its salt is 0.005 to 5 mass % based on the total mass of the cosmetic. [4] The cosmetic preparation according to any one of [1] to [3], wherein the mass ratio of the amount of the retinol to the amount of the organic acid or a salt thereof is 0.005 to 1. [5] The cosmetic preparation according to any one of [1] to [4], wherein the organic acid is 1-piperidinepropionic acid. [6] A cosmetic preparation according to any one of [1] to [5], further comprising vitamin C or a derivative thereof. [7] The cosmetic according to [6], wherein the blending amount of the vitamin C or a derivative thereof is 0.005 to 1 mass % based on the total mass of the cosmetic. [8] The cosmetic preparation according to [6] or [7], wherein the mass ratio of the amount of vitamin C or its derivative to the amount of the organic acid is 1 / 300 to 1 / 1. Effect of the Invention

[0006] According to the present invention, a cosmetic composition is provided that contains a large amount of retinol, which reduces irritation to the skin and has a high wrinkle improving effect. DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS

[0007] Hereinafter, an embodiment of the present invention will be described in detail.

[0008] The cosmetic composition according to the present invention contains (A) retinol and (B) a specific organic acid as essential ingredients.

[0009] [Retinol] The cosmetic composition according to the present invention contains retinol. Retinol is used in the fields of cosmetics, medicines, quasi-drugs, etc., and any of these may be selected for use in the present invention.

[0010] Retinol (also known as vitamin A) exists in several stereoisomers, including all-trans, 13-cis, and 9-cis, and any of these can be used.

[0011] The amount of retinol is not particularly limited as long as it is an effective amount for exerting the effect of the component, but is usually preferably 0.01 to 0.5% by mass, and more preferably 0.02 to 0.1% by mass, based on the total mass of the cosmetic. By setting the retinol content within this range, a sufficient wrinkle improvement effect can be obtained while suppressing the feeling of irritation.

[0012] [Organic acid or its salt] The cosmetic composition according to the present invention contains a specific organic acid or a salt thereof. The organic acid is represented by the following general formula (I). [ka] (In formula (I), n represents an integer of 2 to 5.) Depending on the number n, this organic acid includes 1-piperidinepropionic acid (n=2), 4-(1-piperidinyl)butanoic acid (n=3), 5-(1-piperidinyl)pentanoic acid (n=4), and 6-(1-piperidinyl)hexanoic acid (n=5). Of these, 1-piperidinepropionic acid is particularly preferred because it not only suppresses the irritation caused by retinol, but also improves skin quality to make it less prone to roughness, and has the effect of suppressing the formation of wrinkles.

[0013] Furthermore, the salts of such organic acids are not particularly limited, and examples of the inorganic salts include hydrochloride, sulfate, phosphate, hydrobromide, sodium salt, potassium salt, magnesium salt, calcium salt, ammonium salt, etc. Examples of the organic salts include acetate, lactate, maleate, fumarate, tartrate, citrate, methanesulfonate, p-toluenesulfonate, triethanolamine salt, diethanolamine salt, amino acid salt, etc.

[0014] The amount of the organic acid or its salt is not particularly limited, but is preferably 0.005 to 5 mass %, and more preferably 0.01 to 4 mass %, based on the total mass of the cosmetic. By having the amount of the organic acid or its salt within this range, it is possible to suppress the feeling of irritation, and to obtain a cosmetic that has an excellent feeling of moisturization, is less sticky, and has an excellent feeling of use.

[0015] In the present invention, in order to optimally maintain the balance between the wrinkle improving effect of retinol and the irritation suppressing effect of the organic acid or its salt, the mass ratio (a·b) of the amount (a) of retinol to the amount (b) of the organic acid or its salt is preferably 0.005 to 1, and more preferably 0.01 to 0.5.

[0016] [Other ingredients] The cosmetic composition according to the present invention contains the above-mentioned retinol and an organic acid or a salt thereof as essential components, but may contain other components as necessary.

[0017] Among such ingredients, vitamin C or its derivatives can be mentioned as an ingredient that is preferably blended into the cosmetic product according to the present invention. Vitamin C is known as a nutrient, and corresponds to L-ascorbic acid as a compound. Vitamin C or its derivatives are commonly used in cosmetics. Vitamin C or its derivatives are known to have whitening effects, and in the present invention, it exhibits an effect of supplementing the irritation suppressing effect of the organic acid or its salt described above.

[0018] Vitamin C is water-soluble, and its derivatives are known to be water-soluble, oil-soluble, and amphiphilic, but the water-soluble ones are preferably used.Specific examples include 2-O-ethyl ascorbic acid, 3-O-ethyl ascorbic acid, sodium ascorbyl phosphate, magnesium ascorbyl phosphate, ascorbyl glucoside, glyceryl ascorbic acid, 3-glyceryl ascorbic acid, bisglyceryl ascorbic acid, and L-ascorbic acid palmitate.

[0019] The amount of vitamin C or its derivatives is not particularly limited, but is preferably 0.005 to 1 mass %, and more preferably 0.008 to 0.2 mass %, based on the total mass of the cosmetic. By having the amount of vitamin C or its derivatives in this range, the cosmetic can be made to have an excellent wrinkle improving effect, little irritation, and excellent usability.

[0020] In the present invention, in order to optimally balance the wrinkle improving effect and the irritation suppressing effect, the mass ratio (c / b) of the amount (c) of vitamin C or a derivative thereof to the amount (b) of the organic acid or a salt thereof is preferably 1 / 300 to 1, and more preferably 1 / 200 to 1 / 3.

[0021] The cosmetic product according to the present invention may further contain, as necessary, appropriate ingredients that are typically used in cosmetics and pharmaceuticals, such as water, oils, surfactants, powders, coloring materials, alcohols, thickeners, chelating agents, silicones, antioxidants, UV absorbers, moisturizers, fragrances, various medicinal ingredients, preservatives, pH adjusters, neutralizing agents, and the like.

[0022] The cosmetic according to the present invention preferably contains a large amount of water in order to form a beauty serum or emulsion having a wrinkle improving effect. The water used in cosmetics, quasi-drugs, etc. can be used, for example, purified water, ion-exchanged water, tap water, etc. The amount of water varies depending on the amount of other ingredients, but is generally preferably 20 to 80% by mass, more preferably 30 to 70% by mass, based on the total mass of the cosmetic.

[0023] The cosmetic according to the present invention may contain a polyhydric alcohol. Such a polyhydric alcohol may be selected from a range that does not impair the effects of the present invention. Specifically, the polyhydric alcohol is preferably one or more selected from the group consisting of glycerin, diglycerin, polyglycerin, 1,3-butylene glycol, ethylene glycol, propylene glycol, dipropylene glycol, polyethylene glycol, polypropylene glycol, polyethylene glycol-polypropylene glycol, trimethylolethane, trimethylolpropane, erythritol, pentaerythritol, sorbitan, glucose, sorbitol, maltitol, sucrose, raffinose, hexylene glycol, 1,2-pentanediol, and trehalose.

[0024] Polyhydric alcohols exert moisturizing and warming functions, and the amount of polyhydric alcohol added is adjusted according to the purpose. In general, the amount of polyhydric alcohol added is preferably 1 to 30% by mass, and more preferably 5 to 20% by mass, based on the total mass of the cosmetic.

[0025] The cosmetic according to the present invention may contain a higher alcohol. In the present invention, the higher alcohol is not particularly limited as long as it can be used in the fields of cosmetics, medicines, quasi-drugs, etc. Specific examples include lauryl alcohol, myristyl alcohol, cetyl alcohol, stearyl alcohol, behenyl alcohol, etc. Mixtures of these, such as cetearyl alcohol (cetostearyl alcohol), which is a mixture of stearyl alcohol and cetyl alcohol, are also commonly known and can also be used.

[0026] When higher alcohol is added, one or more of the above can be used. In the present invention, it is preferable to use a mixture of two or more aliphatic alcohols, and more preferably, the mixture has a melting point of 60°C or higher. If the melting point is less than 60°C, the temperature stability of the system may decrease depending on the formulation. In the present invention, for example, a combination of stearyl alcohol and behenyl alcohol is preferable.

[0027] The blending amount of the higher alcohol is preferably from 0.1 to 10% by mass, and more preferably from 0.5 to 5% by mass, relative to the total mass of the cosmetic.

[0028] The cosmetic according to the present invention may contain a surfactant. Various types of surfactants are known, such as nonionic, cationic, anionic, amphoteric, and silicone-based, and any one of them may be selected and used. The amount of the surfactant is preferably 0.1 to 20% by mass, and more preferably 0.3 to 5% by mass, based on the total amount of the oil-in-water emulsion cosmetic.

[0029] The cosmetic according to the present invention may contain any oil depending on the purpose. The oil that can be used in the present invention is not particularly limited, and may be selected from those used in cosmetics as long as the stability is not impaired. Preferred oils include polar oils such as hydrocarbon oils and ester oils, silicone oils, and liquid oils and fats.

[0030] in particular, Hydrocarbon oils include liquid paraffin, squalane, squalene, paraffin, isoparaffin, ceresin, isohexadecane, and isododecane; Examples of polar oils such as ester oils include pentaerythrityl tetraethylhexanoate, cetyl ethylhexanoate, jojoba oil, di(phytosteryl / octyldodecyl) lauroyl glutamate, triisostearin, glyceryl diisostearate, triethylhexanoin, phytosteryl / behenyl dimer dilinoleate, phytosteryl / isostearyl / cetyl / stearyl / isostearyl / cetyl / stearyl / behenyl dimer dilinoleate, isopropyl palmitate, phytosteryl macadamia nut fatty acid, pentaerythrityl tetra(behenate / benzoate / ethylhexanoate), ethylhexyl palmitate, myristyl myristate, isopropyl myristate, tripropylene glycol dipivalate, diisopropyl sebacate, and isodecyl neopentanoate; Examples of silicone oils include chain silicones such as dimethylpolysiloxane, methylphenylpolysiloxane, and methylhydrogenpolysiloxane, cyclic silicones such as octamethylcyclotetrasiloxane, decamethylcyclopentasiloxane, and dodecamethylcyclohexasiloxane, silicone resins that form a three-dimensional network structure, and silicone rubber; and Liquid oils and fats include linseed oil, camellia oil, macadamia nut oil, corn oil, mink oil, olive oil, avocado oil, camellia oil, castor oil, safflower oil, rapeseed oil, soybean oil, peanut oil, triglycerin, glycerin trioctanoate, and glycerin triisopalmitate. In addition, when these oils are contained, it is preferable that the cosmetic composition is an oil-in-water type cosmetic.

[0031] The blending amount of the oil is not particularly limited, but is preferably 5 to 40% by mass based on the total amount of the oil-in-water emulsion cosmetic.

[0032] The cosmetic preparation according to the present invention may further contain ingredients depending on the purpose, such as amino acids, bactericides, anti-inflammatory agents, astringents, animal and plant extracts, vitamins other than vitamin C and their derivatives, chelating agents, pigments, antioxidants, preservatives, and fragrances.

[0033] [Cosmetics] The cosmetic according to the present invention contains the above-mentioned essential components, and can be used in any formulation that a general cosmetic can take. For example, it can be in the form of a beauty essence, emulsion, lotion, cream, aerosol, etc. Regardless of the formulation, it can be a cosmetic that achieves the wrinkle improving effect while providing low irritation and excellent usability. EXAMPLES

[0034] [Examples 1 to 11, Comparative Examples 1 to 4] Cosmetics of each of the Examples and Comparative Examples were prepared according to the formulations shown in Table 1.

[0035] Furthermore, the cosmetics were evaluated for irritation and moisturizing sensation during use according to the following criteria.

[0036] [Evaluation method] A practical test was conducted by a panel of 20 experts using each cosmetic product. The test items were non-irritation and moisturizing sensation. Each expert panel evaluated each test item based on the following evaluation criteria, and the products were ranked according to the total score.

[0037] Evaluation criteria (stimulation, moisturizing): 5 points: Very good. 4 points: Excellent. 3 points: Average. 2 points: Poor. 1 point: Very poor.

[0038] Stimulating sensation rating A+: Total score is 90 or more A: Total score is 80 or more B: Total score is between 60 and 80 points C: Total score is between 40 and 60 points D: Total score is less than 40 points

[0039] Moisture rating A: Total score is 80 or more B: Total score is between 60 and 80 points C: Total score is between 40 and 60 points D: Total score is less than 40 points

[0040] [Table 1-1]

[0041] [Table 1-2]

[0042] When comparing Comparative Examples 1 and 3 with Comparative Examples 2 and 4, it is found that, as previously reported, the inclusion of retinol tends to significantly deteriorate the irritation and moisturizing sensation. However, in the examples, even when the amount of retinol is increased to about 2.5 times that of Comparative Examples 1 and 3, the improvement is comparable to the level when no retinol is included. On the other hand, Comparative Examples 2 and 4 are less irritating because they do not contain retinol, but it is clear that they do not achieve the wrinkle improvement effect, which is one of the objects of the present invention. From the above results, it was found that the cosmetic composition according to the present invention can be incorporated with a high content of retinol, and therefore can achieve an excellent wrinkle improvement effect, while at the same time providing less irritation and excellent moisturizing sensation.

Claims

1. (A) retinol, and (B) A compound represented by the following general formula (I): 【Chemistry 1】 (In formula (I), n represents an integer of 2 to 5.) An organic acid represented by the formula: A cosmetic comprising:

2. 2. The cosmetic according to claim 1, wherein the blending amount of the retinol is 0.01 to 0.5% by mass based on the total mass of the cosmetic.

3. 3. The cosmetic according to claim 1, wherein the blending amount of the organic acid or its salt is 0.005 to 5% by mass based on the total mass of the cosmetic.

4. The cosmetic preparation according to any one of claims 1 to 3, wherein a mass ratio of the blended amount of the retinol to the blended amount of the organic acid or its salt is 0.005 to 1.

5. The cosmetic preparation according to any one of claims 1 to 4, wherein the organic acid is 1-piperidinepropionic acid.

6. The cosmetic preparation according to any one of claims 1 to 5, further comprising vitamin C or a derivative thereof.

7. The cosmetic according to claim 6, wherein the blending amount of vitamin C or a derivative thereof is 0.005 to 1 mass % based on the total mass of the cosmetic.

8. 8. The cosmetic preparation according to claim 6, wherein a mass ratio of the blended amount of the vitamin C or a derivative thereof to the blended amount of the organic acid is 1 / 300 to 1 / 1.

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