Normal bacteria antibacterial agent

Abstract

To provide a novel antibacterial polymer agent against indigenous bacteria on skin.SOLUTION: An antibacterial agent against indigenous bacteria on skin contains a copolymer. The copolymer has a constitutional unit (a) represented by general formula (1) and / or (2) and a constitutional unit (b) derived from a hydrophobic monomer with its homopolymer having a solubility parameter of 15 or less. (In the general formula (1) or (2), R1-R3 independently represent H or a C1-12 organic group, R4-R8 independently represent H or a C1-5 alkyl group, Y-is an anion).SELECTED DRAWING: None

Description

[Technical field]

[0001] The present invention relates to an antibacterial agent for normal flora, and more particularly to an antibacterial agent for normal flora used in skin cosmetics, skin external preparations, hair cosmetics, and the like. [Background technology]

[0002] Conventionally, paraben, phenoxyethanol, benzoic acid and its salts, salicylic acid and its salts, etc. have been used as antibacterial agents for cosmetics, but these agents have problems such as high skin irritation and insufficient antibacterial performance at low concentrations. There is an increasing demand for more effective and safe antibacterial agents. To solve these problems, polymer-based antibacterial agents for cosmetics have been developed. Generally, substances with a molecular weight of more than 1000 are considered to be difficult to permeate through the skin, and it is considered that a polymer-type antibacterial agent with a sufficiently large molecular weight can be used safely even by people with sensitive or atopic skin. For example, it has been reported that a polymer antibacterial agent consisting of a copolymer of an amino group-containing monomer and a hydrophobic monomer has antibacterial effects against Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, Candida, and Aspergillus niger. (See Patent Document 1) [Prior art documents] [Patent documents]

[0003] [Patent Document 1] JP 2018-058813 A Summary of the Invention [Problem to be solved by the invention]

[0004] As described above, various polymer antibacterial agents have been reported, but there has been a demand for a polymer antibacterial agent having antibacterial activity against resident skin bacteria. Therefore, an object of the present invention is to provide a novel polymer antibacterial agent for resident skin bacteria. [Means for solving the problem]

[0005] The present inventors have conducted various investigations to achieve the above object and have arrived at the present invention. That is, the resident flora antibacterial agent of the present disclosure is an resident skin flora antibacterial agent comprising a copolymer, the copolymer having a structural unit (a) derived from an amino group-containing monomer and a structural unit (b) derived from a hydrophobic monomer, the structural unit (a) derived from the amino group-containing monomer being represented by the following general formula (1) and / or (2), and the hydrophobic monomer being a homopolymer having a solubility parameter of 15 or less.

[0006] [ka]

[0007] [ka]

[0008] In the general formula (1) or (2), R1, R2, and R3 each independently represent a hydrogen atom or an alkyl group having 1 to 5 carbon atoms, R4 to R8 each independently represent a hydrogen atom or an organic group having 1 to 12 carbon atoms, and Y - represents an anion, where an asterisk represents an atom contained in another structural unit of the same or different type to which the structural unit represented by general formula (1) or (2) is bonded. Effect of the Invention

[0009] The resident flora antibacterial agent of the present disclosure exhibits antibacterial activity against Malassezia genus, Propionibacterium acnes, etc., even when added at a low concentration. Therefore, the resident flora antibacterial agent of the present disclosure can be preferably used, for example, as a resident flora antibacterial agent for scalp or skin care products. DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS

[0010] The present disclosure will be described in detail below. In addition, a combination of two or more of the individual preferred embodiments of the present disclosure described below is also a preferred embodiment of the present disclosure. [Copolymers of the present disclosure] The indigenous bacteria antibacterial agent of the present disclosure includes a copolymer including a structural unit derived from an amino group-containing monomer and a structural unit derived from a hydrophobic monomer. The above polymer may be referred to as the copolymer of the present disclosure. <Structural unit derived from amino group-containing monomer> In the present disclosure, the structural unit derived from an amino group-containing monomer is represented by a structural unit of the following general formula (1) and / or (2).

[0011] [ka]

[0012] [ka]

[0013] In the general formula (1) or (2), R1, R2, and R3 each independently represent a hydrogen atom or an alkyl group having 1 to 5 carbon atoms, R4 to R8 each independently represent a hydrogen atom or an organic group having 1 to 12 carbon atoms, and Y - represents an anion. However, an asterisk represents an atom contained in another structural unit of the same type or different type to which the structural unit represented by general formula (1) or (2) is bonded. In this disclosure, "atoms contained in another structural unit of the same type" refers to atoms contained in another structural unit represented by general formula (1), for example, in the case of a structural unit represented by general formula (1), and "atoms contained in another structural unit of a different type" refers to atoms contained in a structural unit other than the structural unit represented by general formula (1), for example, in the case of a structural unit represented by general formula (1). The structure derived from the amino group-containing monomer can be formed, for example, by radical polymerization of a monomer having an ethylenically unsaturated group and a primary to tertiary amino group represented by the following general formula (3), or a neutralized product of a primary to tertiary amino group with an acid, or a quaternary ammonium salt group represented by the following general formula (4), but is not limited thereto.

[0014] [ka]

[0015] [ka]

[0016] R4 to R8 in the general formula (3) and the general formula (4) are the same as R4 to R8 in the general formula (1) and the general formula (2). The structural unit derived from the amino group-containing monomer preferably contains a structural unit represented by general formula (1) or (2) in which -X- is -C(=O)-O-CH2CH2-. The structural unit derived from the amino group-containing monomer is formed, for example, by radical polymerization of the amino group-containing monomer.Specific examples of the amino group-containing monomer include N,N-dialkylamino group-containing (meth)acrylates such as N,N-dimethylaminoethyl (meth)acrylate, N,N-diethylaminoethyl (meth)acrylate, N,N-dimethylaminopropyl (meth)acrylate, and N,N-diethylaminopropyl (meth)acrylate, as well as monomers obtained by adding a quaternizing agent to the above monomers or their neutralization with an acid such as hydrochloric acid or acetic acid; N,N-dimethylaminoethyl (meth)acrylamide, N,N-diethyl ... N,N-dialkylamino group-containing (meth)acrylamides such as N,N-dimethylaminopropyl (meth)acrylamide, N,N-diethylaminopropyl (meth)acrylamide, and monomers obtained by adding a quaternizing agent to the above-mentioned monomers, or neutralized products thereof with an acid such as hydrochloric acid or acetic acid; monomethylaminoethyl (meth)acrylate, monoethylaminoethyl (meth)acrylate, monomethylaminopropyl (meth)acrylate, monoethylaminopropyl (meth)acrylate, 2-(tert-butyl acrylate (meth)acrylate, monoalkylamino group-containing (meth)acrylates such as monomethylaminoethyl (meth)acrylamide, monoethylaminoethyl (meth)acrylamide, monomethylaminopropyl (meth)acrylamide, monoethylaminopropyl (meth)acrylamide and the like, and their neutralization with acids such as hydrochloric acid, acetic acid and the like; monoalkylamino group-containing (meth)acrylamides such as monomethylaminoethyl (meth)acrylamide, monoethylaminoethyl (meth)acrylamide, monomethylaminopropyl (meth)acrylamide and the like, and their neutralization with acids such as hydrochloric acid, acetic acid and the like; esters of (meth)acrylic acid and alkanolamines such as 2-aminoethyl (meth)acrylate and the like, and their neutralization with acids such as hydrochloric acid, acetic acid and the like Examples of the neutralized product include a product neutralized with an acid such as hydrochloric acid or acetic acid; a monomer obtained by adding N,N-diallylmethylamine to a quaternizing agent, or a product neutralized with an acid such as hydrochloric acid or acetic acid; an allylamine or a product neutralized with an acid such as hydrochloric acid or acetic acid; an addition reaction product of an unsaturated monomer having a cyclic ether-containing group having 2 to 8 carbon atoms, such as 1-allyloxy-3-dibutylamino-2-ol or 1-allyloxy-3-diethanolamino-2-ol, with an amine compound having 1 to 24 carbon atoms, and a monomer obtained by adding a quaternizing agent to the monomer, or a product neutralized with an acid such as hydrochloric acid or acetic acid. The structural unit derived from the amino group-containing monomer is preferably a structural unit derived from N,N-dimethylaminoethyl (meth)acrylate, represented by the following general formula (5).

[0017] [ka]

[0018] R9 in the above general formula (5) represents a hydrogen atom or a methyl group. However, the asterisk represents an atom contained in another structural unit of the same or different type to which the structural unit represented by general formula (1) or (2) is bonded. Most preferred is a structural unit derived from N,N-dimethylaminoethyl (meth)acrylate. The content of the structural unit derived from the amino group monomer in the copolymer of the present disclosure is 1% by mass or more and 99% by mass or less, preferably 10% by mass or more and 97% by mass or less, more preferably 36% by mass or more and 96% by mass or less, and most preferably 60% by mass or more and 95% by mass or less, based on 100% by mass of the structural units derived from all the monomers constituting the copolymer of the present disclosure. By being in the above range, the proportion of cationic sites that can act on microbial membranes becomes appropriate, and the antibacterial performance of the antibacterial agent of the present disclosure tends to be improved. <Structural units derived from hydrophobic monomers> In the present disclosure, a structural unit derived from a hydrophobic monomer is a structural unit derived from a monomer that produces a homopolymer obtained by homopolymerizing the hydrophobic monomer, the homopolymer having a solubility parameter of 15 or less. The structure derived from the hydrophobic monomer represents, for example, a structural unit in which the carbon-carbon double bond of a monomer having an ethylenically unsaturated group and a hydrophobic group is replaced with a carbon-carbon single bond. These structural units can be formed, for example, by radical polymerization of the monomer. The structural unit derived from the hydrophobic group-containing monomer may have the same structure as the structural unit in which the carbon-carbon double bond is replaced with a carbon-carbon single bond, and may be, for example, a structural unit formed by a post-polymerization reaction. Even if the solubility parameter is 15 or less, those having an amino group are included in the amino group-containing monomer, and are not included in the hydrophobic monomer. The solubility parameter is a value calculated by the method described on pages 147 to 154 of "POLYMER ENGINEERING AND SCIENCE" (1974, Vol. 14, No. 2). The method is outlined below. The solubility parameter (δ) (cal / cm3)1 / 2 of a homopolymer is calculated by the following calculation method based on the vaporization energy (△ei) and molar volume (△vi) of the structural units that form the polymer. δ=(△ei / △vi)1 / 2(cal / cm3)1 / 2. The hydrophobic monomer (B) is not particularly limited as long as the solubility parameter of the homopolymer is 15 or less, and examples thereof include esters of (meth)acrylic acid and alcohol which may have a substituent ((meth)acrylate which may have a substituent); unsaturated monocarboxylic acids such as (meth)acrylic acid, crotonic acid, α-allyloxyacrylic acid, and salts thereof; aromatic vinyl monomers such as styrene; olefin monomers such as propylene; esters of unsaturated alcohols and carboxylic acids such as vinyl acetate; vinyl halides such as vinyl chloride; methyl vinyl Examples of the hydrophobic monomers include alkyl vinyl ethers such as allyl ether and ethyl vinyl ether; addition reaction products of unsaturated monomers having a cyclic ether-containing group having 2 to 8 carbon atoms, such as 1-allyloxy-3-butoxypropan-2-ol, with alcohols having 1 to 20 carbon atoms; alkylene oxide adducts of unsaturated alcohols having 2 to 20 carbon atoms, such as ethylene oxide adducts of allyl alcohol, ethylene oxide adducts of methallyl alcohol, and ethylene oxide adducts of isoprenol, and their terminal hydrophobically modified products; and cyclic vinyl monomers such as N-vinylpyrrolidone. Among the hydrophobic monomers having a solubility parameter of 15 or less, those having an alkyl group having 2 or more carbon atoms are preferred. When the hydrophobic monomer has an alkyl group having 2 or more carbon atoms, the affinity with the cell membrane of microorganisms is increased, and the antibacterial properties are further improved. The hydrophobic monomer (B) preferably contains at least one (meth)acrylic acid ester. The (meth)acrylic acid ester is preferably an ester of (meth)acrylic acid and a monoalcohol, and is a compound in which the carbon number of the hydrocarbon group of the monoalcohol is 1 to 20. The carbon number of the hydrocarbon group of the monoalcohol is more preferably 1 to 16, even more preferably 1 to 12, particularly preferably 1 to 8, and most preferably 2 to 8. If the carbon number of the hydrocarbon group is 1 to 20, the water solubility and viscosity of the polymer can be set in a suitable range, and the polymer is excellent in handleability. If the carbon number of the hydrocarbon group is 1 to 12, the polymer is easy to produce, and further, the polymer is excellent in safety in addition to antibacterial properties. Furthermore, if the carbon number of the hydrocarbon group is 2 to 8, not only is the polymer easy to produce, but it is also safe and has an increased affinity with the cell membrane of microorganisms, resulting in improved antibacterial properties. The hydrocarbon group is preferably an alkyl group or an alkenyl group, and more preferably an alkyl group. That is, the (meth)acrylic acid ester is preferably an alkyl (meth)acrylic acid ester (alkyl (meth)acrylate), and the hydrophobic monomer (B) preferably contains at least one kind of an alkyl (meth)acrylic acid ester. Among these, a structural unit derived from ethyl (meth)acrylate and represented by the following general formula (6) is particularly preferred.

[0019] [ka]

[0020] In the above general formula (6), R 10 represents a hydrogen atom or a methyl group. However, an asterisk represents an atom contained in another structural unit of the same type or different type to which the structural unit represented by general formula (1) or (2) is bonded. Most preferred is a structural unit derived from ethyl methacrylate. The content of the structural unit derived from the hydrophobic monomer in the copolymer of the present disclosure is 1% by mass or more and 99% by mass or less, preferably 3% by mass or more and 90% by mass or less, more preferably 4% by mass or more and 64% by mass or less, and most preferably 5% by mass or more and 40% by mass or less, based on 100% by mass of the structural units derived from all monomers constituting the copolymer of the present disclosure. If the content ratio is within such a range, the copolymer has appropriate hydrophobicity and has an increased ability to disrupt the membrane of microorganisms, thereby improving antibacterial performance, and tends to show high antibacterial performance against gram-negative bacteria such as Escherichia coli and Pseudomonas aeruginosa, which have an outer membrane.

[0021] <Structural units derived from other monomers> The copolymer of the present disclosure may have a structural unit derived from a monomer other than the structural unit derived from the amino group-containing monomer and the structural unit derived from the hydrophobic monomer (also referred to as a structural unit derived from other monomers) as desired. The other monomer is not particularly limited as long as it does not have an amino group and can be copolymerized with the amino group-containing monomer and the hydrophobic monomer. As long as the hydrophobic monomer is polymerized in a preferred ratio, the hydrophobicity of the copolymer is sufficiently maintained. In the present disclosure, the structural unit derived from the other monomer refers to a structural unit in which at least one carbon-carbon double bond of the other monomer is replaced with a carbon-carbon single bond. The structural unit derived from the other monomer may have the same structure as the structure in which at least one carbon-carbon double bond of the other monomer is replaced with a carbon-carbon single bond, and is not limited to a structural unit formed by polymerization of the other monomer, and may be, for example, a structural unit formed by a post-reaction after polymerization. The content of the structural unit derived from the other monomer in the copolymer of the present disclosure is 0% by mass or more and 15% by mass or less, preferably 0% by mass or more and 10% by mass or less, more preferably 0% by mass or more and 5% by mass or less, based on 100% by mass of the structural units derived from all the monomers constituting the copolymer of the present disclosure. These other monomers may be used alone or in combination of two or more kinds.

[0022] <Physical properties of the copolymer of the present disclosure> The copolymer of the present disclosure preferably has a weight average molecular weight (Mw) of 4000 or more and 800000 or less, more preferably 6000 or more and 400000 or less, and even more preferably 7000 or more and 80000 or less. By being in the above range, the antibacterial performance of the antibacterial agent of the present disclosure is further improved, and the preparation tends to be easy to handle with excellent water solubility and dispersibility.

[0023] [Method for producing the copolymer of the present disclosure] The method for producing the copolymer of the present disclosure is not particularly limited, but it is preferable to produce it by polymerizing structural units derived from an amino group-containing monomer, a hydrophobic group-containing monomer, and other monomers as necessary. The method for producing the copolymer can be, for example, solution polymerization, bulk polymerization, suspension polymerization, emulsion polymerization, living polymerization, graft polymerization, etc., and is not particularly limited, but solution polymerization is preferable. The solvent used in this case is not particularly limited, but water; monohydric alcohols such as methyl alcohol, ethyl alcohol, isopropyl alcohol, butanol, and THF (tetrahydrofuran); polyhydric alcohols such as glycerin, (poly)ethylene glycol, propylene glycol, 1,3-butylene glycol, and dipropylene glycol; aromatic or aliphatic hydrocarbons such as benzene, toluene, xylene, cyclohexane, and n-heptane; esters such as ethyl acetate; ketones such as acetone and methyl ethyl ketone; amides such as dimethylformamide; ethers such as diethyl ether and dioxane, etc. are suitable. These may be used alone or in combination of two or more. Among these, from the viewpoint of the solubility of the monomer components and the resulting copolymer, it is preferable to use one or more solvents selected from the group consisting of water and lower alcohols having 1 to 4 carbon atoms. A polyhydric alcohol solvent such as propylene glycol or ethylene glycol may be added to water for polymerization. By using the above polyhydric alcohol solvent in combination with water, the solubility of the polymer can be increased and soap-free polymerization can be more sufficiently suppressed. This makes it possible to more sufficiently suppress the generation of a polymer with poor water solubility and to further improve the transparency of the solution. In addition, a solvent made of water, ethyl alcohol, glycerin, 1,3-butanediol, or a combination of two or more of them is even more preferable in that it can be used directly as a raw material for a skin external preparation without carrying out a desolvation process.

[0024] [Common flora of the present disclosure] Resident bacteria refers to microorganisms present on the human body, such as the skin, scalp, and mucous membranes, that are carried by many people. In the present disclosure, the term "resident bacteria" refers to those generally called bad bacteria, such as Malassezia fungi, which are lipophilic fungi that are closely related to the occurrence of dandruff, and acne bacteria, which grow excessively in the sebum of human skin and cause inflammation. By reducing these bacteria, it is possible to obtain effects such as reducing dandruff and improving inflammatory skin. The genus Malassezia refers to fungi belonging to the Malassezia genus, and specifically includes Malassezia furfur, Malassezia globosa, and Malassezia restricta. The term "acne bacteria" refers to Cutibacterium acnes, a bacterium of the Cutibacterium genus.

[0025] [Common flora antibacterial agent of the present disclosure] The resident flora antibacterial agent of the present disclosure essentially contains the copolymer of the present disclosure. The content of the copolymer of the present disclosure in the resident flora antibacterial agent of the present disclosure may be 100% by mass at the upper limit, and is not particularly limited at the lower limit, but is preferably 30% by mass or less from the viewpoint of making the viscosity easy to handle. The resident flora antibacterial agent of the present disclosure may contain a solvent such as water, other antibacterial agents, preservatives, etc. The other components are not particularly limited as long as they do not inhibit the antibacterial activity of the resident flora antibacterial agent, and examples thereof include additives such as alkali regulators, anionic surfactants, compatibilizers, stabilizers, and other antibacterial agents. In addition, the resident flora antibacterial agent of the present invention may further contain metal salts, metal oxides, metal hydroxides, etc., from the viewpoint of improving antibacterial properties. The content of the other components is not particularly limited as long as they do not inhibit the antibacterial activity of the resident flora antibacterial agent, and is preferably 0 to 20% by mass relative to 100% by mass of the copolymer. Furthermore, the resident flora antibacterial agent of the present invention may be blended with water as needed, as well as additives generally blended in cosmetics and topical skin preparations, such as oily bases, moisturizers, texture enhancers, surfactants, polymers, thickening / gelling agents, solvents, propellants, antioxidants, reducing agents, oxidizing agents, preservatives / antibacterial agents other than the preservative / antibacterial agent of the present invention, chelating agents, pH adjusters, acids, alkalis, powders, inorganic salts, UV absorbers, skin whitening agents, vitamins and derivatives thereof, anti-inflammatory agents, anti-inflammatory agents, hair growth agents, blood circulation promoters, stimulants, hormones, anti-wrinkle agents, anti-aging agents, tightening agents, cooling agents, warming agents, wound healing promoters, irritation relievers, analgesics, cell activators, plant / animal / microbial extracts, antipruritics, keratin exfoliating / dissolving agents, antiperspirants, cooling agents, astringents, enzymes, nucleic acids, fragrances, dyes, colorants, dyes, pigments, water, etc.

[0026] Examples of these added components include oily bases such as higher alcohols such as cetanol, myristyl alcohol, oleyl alcohol, lauryl alcohol, cetostearyl alcohol, stearyl alcohol, arachyl alcohol, behenyl alcohol, jojoba alcohol, chimyl alcohol, selachyl alcohol, batyl alcohol, hexyldecanol, isostearyl alcohol, 2-octyldodecanol, and dimer diol; aralkyl alcohols and derivatives such as benzyl alcohol; lauric acid, Higher fatty acids such as myristic acid, palmitic acid, stearic acid, isostearic acid, behenic acid, undecylenic acid, 12-hydroxystearic acid, palmitoleic acid, oleic acid, linoleic acid, linoleic acid, erucic acid, docosahexaenoic acid, eicosapentaenoic acid, isohexadecanoic acid, anteisohenicosanoic acid, long-chain branched fatty acids, dimer acids, hydrogenated dimer acids, and the like, and metal soaps such as their aluminum salts, calcium salts, magnesium salts, zinc salts, potassium salts, and nitrogen-containing derivatives such as amides; Raffin (mineral oil), heavy liquid isoparaffin, light liquid isoparaffin, α-olefin oligomer, polyisobutene, hydrogenated polyisobutene, polybutene, squalane, olive-derived squalane, squalene, petrolatum, solid paraffin, hydrogenated polydecene and other hydrocarbons; candelilla wax, carnauba wax, rice wax, Japan wax, beeswax, montan wax, ozokerite, ceresin, paraffin wax, microcrystalline wax, petrolatum, Fischer-Tropsch wax waxes such as ethylene-propylene copolymer, polyethylene wax, and ethylene-propylene copolymer; coconut oil, palm oil, palm kernel oil, safflower oil, olive oil, castor oil, avocado oil, sesame oil, tea oil, evening primrose oil, wheat germ oil, macadamia nut oil, hazelnut oil, kukui nut oil, rosehip oil, meadowfoam oil, persic oil, tea tree oil, peppermint oil, corn oil, rapeseed oil, sunflower oil, wheat germ oil, linseed oil, cottonseed oil, soybean oil, peanut oil, rice bran oil, cocoa butter, shea butter, hydrogenated coconut oil, hydrogenated castor oil Vegetable fats and oils such as shiitake oil, jojoba oil, and hydrogenated jojoba oil; animal fats and oils such as beef tallow, milk fat, horse fat, egg yolk oil, mink oil, and turtle oil; animal waxes such as whale wax, lanolin, and orange roughy oil;

[0027] Lanolin derivatives such as liquid lanolin, reduced lanolin, adsorbed purified lanolin, acetated lanolin, acetated liquid lanolin, hydroxylanolin, polyoxyethylene lanolin, lanolin fatty acid, hard lanolin fatty acid, lanolin alcohol, acetated lanolin alcohol, acetate (cetyl lanoyl) ester; lecithin, phosphatidylcholine, phosphatidylethanolamine, phosphatidylserine, phosphatidylglycerol, phosphatidylinositol, sphingophospholipids such as sphingomyelin, phosphatidic acid, lysolecithin, etc. Phospholipid derivatives such as hydrogenated soybean phospholipid, partially hydrogenated soybean phospholipid, hydrogenated egg yolk phospholipid, partially hydrogenated egg yolk phospholipid; sterols such as cholesterol, dihydrocholesterol, lanosterol, dihydrolanosterol, phytosterol, cholic acid; sapogenins; saponins; cholesteryl acetate, cholesteryl nonanoate, cholesteryl stearate, cholesteryl isostearate, cholesteryl oleate, di(cholesteryl / behenyl / octyldodecyl) N-lauroyl-L-glutamate, N-lauroyl acyl sarcosine alkyl esters such as N-lauroyl-L-glutamate di(cholesteryl / octyldodecyl), N-lauroyl-L-glutamate di(phytosteryl / behenyl / octyldodecyl), N-lauroyl-L-glutamate di(phytosteryl / octyldodecyl), and N-lauroyl sarcosine isopropyl; sterol esters such as 12-hydroxystearate, cholesteryl macadamiate, phytosteryl macadamiate, phytosteryl isostearate, cholesteryl soft lanolinate, cholesteryl hard lanolinate, cholesteryl long-chain branched fatty acid, and cholesteryl long-chain α-hydroxy fatty acid; lipid complexes such as phospholipid-cholesterol complex and phospholipid-phytosterol complex;

[0028] Octyldodecyl myristate, hexyldecyl myristate, octyldodecyl isostearate, cetyl palmitate, octyldodecyl palmitate, cetyl octanoate, hexyldecyl octanoate, isotridecyl isononanoate, isononyl isononanoate, octyl isononanoate, isotridecyl isononanoate, isodecyl neopentanoate, isotridecyl neopentanoate, isostearyl neopentanoate, octyldodecyl neodecanoate, oleyl oleate, octyldodecyl oleate, octyldodecyl ricinoleate, octyldodecyl lanolinate, hexyldecyl dimethyloctanoate Monoalcohol carboxylic acid esters such as octyldodecyl erucate, hydrogenated castor oil isostearate, ethyl oleate, ethyl avocado oil fatty acid, isopropyl myristate, isopropyl palmitate, octyl palmitate, isopropyl isostearate, isopropyl lanolin fatty acid, diethyl sebacate, diisopropyl sebacate, dioctyl sebacate, diisopropyl adipate, dibutyloctyl sebacate, diisobutyl adipate, dioctyl succinate, and triethyl citrate; oxyacid esters such as cetyl lactate, diisostearyl malate, and hydrogenated castor oil monoisostearate;

[0029] Triethylhexanoin, glyceryl trioctanoate, glyceryl trioleate, glyceryl triisostearate, glyceryl diisostearate, tri(caprylic acid / capric acid), tri(caprylic acid / capric acid / myristic acid / stearic acid), hydrogenated rosin triglyceride (hydrogenated ester gum), rosin triglyceride (ester gum), glyceryl behenate eicosane diate, trimethylolpropane trioctanoate, trimethylolpropane triisostearate, neopentyl glycol dioctanoate, neopentyl glycol dicaprate, 2-butyl-2-ethyl-1,3-propanediol dioctanoate, propylene glycol dioleate, Polyhydric alcohol fatty acid esters such as pentaerythrityl tetraoctanoate, hydrogenated pentaerythrityl rosin, ditrimethylolpropane triethylhexanoate, ditrimethylolpropane isostearate / sebacic acid, pentaerythrityl triethylhexanoate, dipentaerythrityl hydroxystearic acid / stearic acid / rosin acid, diglyceryl diisostearate, polyglyceryl tetraisostearate, polyglyceryl-10 nonaisostearate, polyglyceryl-8 deca(erucic acid / isostearate / ricinoleic acid), diglyceryl oligoester of hexyldecanoic acid / sebacic acid, and glycol distearate (ethylene glycol distearate);

[0030] Dimer acids or dimers such as diisopropyl dimer dilinoleate, diisostearyl dimer dilinoleate, di(isostearyl / phytosteryl) dimer dilinoleate, phytosteryl / behenyl dimer dilinoleate, phytosteryl / isostearyl / cetyl / stearyl / behenyl dimer dilinoleate, dimer dilinoleyl diisostearate, dimer dilinoleyl hydrogenated rosin condensate, dimer dilinoleic acid hydrogenated castor oil, and hydroxyalkyl dimer dilinoleyl ether. Derivatives of Merdiol; fatty acid alkanolamides such as coconut oil fatty acid monoethanolamide (cocamide MEA), coconut oil fatty acid diethanolamide (cocamide DEA), lauric acid monoethanolamide (lauramide MEA), lauric acid diethanolamide (lauramide DEA), lauric acid monoisopropanolamide (lauramide MIPA), palmitic acid monoethanolamide (paltamide MEA), palmitic acid diethanolamide (paltamide DEA), coconut oil fatty acid methylethanolamide (cocamide methyl MEA); dimethicone ( dimethylpolysiloxane), highly polymerized dimethicone (highly polymerized dimethylpolysiloxane), cyclomethicone (cyclic dimethylsiloxane, decamethylcyclopentasiloxane), phenyl trimethicone, diphenyl dimethicone, phenyl dimethicone, stearoxypropyl dimethylamine, (aminoethyl aminopropyl methicone / dimethicone) copolymer, dimethiconol, dimethiconol crosspolymer, silicone resin, silicone rubber, amino-modified silicones such as aminopropyl dimethicone and amodimethicone, cation-modified silicones, polyether-modified silicones such as dimethicone copolyol, polyglycerin-modified silicones, sugar-modified silicones, carboxylic acid-modified silicones, phosphate-modified silicones, sulfate-modified silicones, alkyl-modified silicones, fatty acid-modified silicones, alkyl ether-modified silicones, amino acid-modified silicones, peptide-modified silicones, fluorine-modified silicones, cation-modified and polyether-modified silicones, amino-modified and polyether-modified silicones, alkyl-modified and polyether-modified silicones, polysiloxane-oxyalkylene copolymers, and other silicones;Preferred examples of the fluorine-based oils include perfluorodecane, perfluorooctane, and perfluoropolyether.

[0031] Moisturizing agents and texture improvers include polyols and their polymers such as glycerin, 1,3-butylene glycol, propylene glycol, 3-methyl-1,3-butanediol, 1,3-propanediol, 2-methyl-1,3-propanediol, trimethylolpropane, pentaerythritol, hexylene glycol, diglycerin, polyglycerin, diethylene glycol, polyethylene glycol, dipropylene glycol, polypropylene glycol, and ethylene glycol-propylene glycol copolymers; glycol alkyl ethers such as diethylene glycol monoethyl ether (ethoxydiglycol), ethylene glycol monoethyl ether, ethylene glycol monobutyl ether, and diethylene glycol dibutyl ether; sugar alcohols such as sorbitol, xylitol, erythritol, mannitol, and maltitol; glucose, fructose, galactose, mannose, triglycerides, and the like; Reose, xylose, arabinose, fucose, ribose, deoxyribose, maltose, trehalose, lactose, raffinose, gluconic acid, glucuronic acid, cyclodextrins (α-, β-, γ-cyclodextrin, and modified cyclodextrins such as maltosylated and hydroxyalkylated), β-glucan, chitin, chitosan, heparin and derivatives, pectin, arabinogalactan, dextrin, dextran, glycogen, ethyl Sugars and their derivatives, such as glucosides, glucosyl ethyl methacrylate polymers or copolymers; hyaluronic acid, sodium hyaluronate; sodium chondroitin sulfate; mucoitin sulfate, caronin sulfate, keratosulfate, dermatan sulfate; Tremella fuciformis extract, Tremella fuciformis polysaccharide; fucoidan; tuberose polysaccharide, naturally occurring polysaccharides; organic acids and their salts, such as citric acid, tartaric acid, lactic acid; urea; 2-pyrrolidone-5-carboxylic acid and its sodium salts, etc.;

[0032] Amino acids and their salts, such as betaine (trimethylglycine), proline, hydroxyproline, arginine, lysine, serine, glycine, alanine, phenylalanine, tyrosine, β-alanine, threonine, glutamic acid, glutamine, asparagine, aspartic acid, cysteine, cystine, methionine, leucine, isoleucine, valine, tryptophan, histidine, and taurine; collagen, fish-derived collagen, atelocollagen, gelatin, elastin, collagen hydrolysis peptides, hydrolyzed collagen, hydroxypropylammonium chloride hydrolysis collagen, elastin hydrolysis peptides, keratin hydrolysis peptides, hydrolyzed keratin, conchiolin hydrolysis peptides, hydrolyzed conchiolin, silk proteolysis peptides, hydrolyzed silk, sodium lauroyl hydrolyzed silk, soybean proteolysis peptides, wheat proteolysis peptides, hydrolyzed wheat protein, Preferred examples of the active ingredient include protein peptides and derivatives thereof such as isoform hydrolyzed peptides and acylated peptides; acylated peptides such as palmitoyl oligopeptide, palmitoyl pentapeptide, palmitoyl tetrapeptide; silylated peptides; lactic acid bacteria culture medium, yeast extract, eggshell membrane protein, bovine submandibular gland mucin, hypotaurine, sesame lignan glycoside, glutathione, albumin, whey; choline chloride, phosphorylcholine; placenta extract, alastin, collagen, animal and plant extracts such as aloe extract, witch hazel water, loofah water, chamomile extract, licorice extract, comfrey extract, silk extract, rose roe extract, yarrow extract, eucalyptus extract, melilot extract, and ceramides such as natural ceramides (types 1, 2, 3, 4, 5, 6), hydroxyceramides, pseudoceramides, sphingoglycolipids, ceramides, and glycoceramide-containing extracts.

[0033] Preferred examples of the surfactant include anionic surfactants, nonionic surfactants, cationic surfactants, amphoteric surfactants, polymeric surfactants, etc. There is no particular limitation on the HLB of the surfactant, and surfactants with a low HLB of about 1 to a high HLB of about 20 can be used, and it is also preferable to combine surfactants with low and high HLB. Examples of preferred surfactants include anionic surfactants such as fatty acid salts, potassium laurate, potassium myristate, etc.; alkyl sulfate ester salts, such as sodium lauryl sulfate, triethanolamine lauryl sulfate, ammonium lauryl sulfate, etc.; polyoxyethylene alkyl sulfates, such as sodium laureth sulfate, triethanolamine laureth sulfate, etc.; acyl N-methyl amino acid salts, such as sodium cocoyl methyl taurate, potassium cocoyl methyl taurate, sodium lauroyl methyl taurate, sodium myristoyl methyl taurate, sodium lauroyl methyl alanine, sodium lauroyl sarcosine, triethanolamine lauroyl sarcosine, sodium lauroyl methyl alanine methyl alanine; sodium cocoyl glutamate, triethanolamine cocoyl glutamate, sodium lauroyl glutamate, sodium myristoyl glutamate, sodium stearoyl glutamate, palmitoyl glutamate, etc. Acyl amino acid salts such as ditriethanolamine laureth acetate and triethanolamine cocoyl alanine; polyoxyethylene alkyl ether acetates such as sodium laureth acetate; succinic acid ester salts such as sodium lauroyl monoethanolamide succinate; fatty acid alkanolamide ether carboxylates; acyl lactates; polyoxyethylene fatty amine sulfates; fatty acid alkanolamide sulfates; fatty acid glyceride sulfates such as sodium hydrogenated coconut oil fatty acid glycerin sulfate; alkyl benzene polyoxyethylene sulfates; olefin sulfonates such as sodium α-olefin sulfonate; alkyl sulfosuccinates such as disodium lauryl sulfosuccinate and dioctyl sodium sulfosuccinate; alkyl ether sulfosuccinates such as disodium laureth sulfosuccinate, sodium monolauroyl monoethanolamide polyoxyethylene sulfosuccinate, and sodium lauryl polypropylene glycol sulfosuccinate;Alkylbenzenesulfonates such as sodium tetradecylbenzenesulfonate and triethanolamine tetradecylbenzenesulfonate; alkylnaphthalenesulfonates; alkanesulfonates; α-sulfofatty acid methyl ester salts; acyl isethionates; alkyl glycidyl ether sulfonates; alkyl sulfoacetates; alkyl ether phosphate ester salts such as sodium laureth phosphate, sodium dilaureth phosphate, sodium trilaureth phosphate, and sodium monoolethate; potassium lauryl phosphate, etc.; alkyl phosphate salts; sodium caseinate; alkyl aryl ether phosphates; fatty acid amide ether phosphates; phospholipids such as phosphatidylglycerol, phosphatidylinositol, and phosphatidic acid; silicone-based anionic surfactants such as carboxylate-modified silicone, phosphate-modified silicone, and sulfate-modified silicone;

[0034] Nonionic surfactants include polyoxyethylene alkyl ethers with various polyoxyethylene addition numbers, such as laureths (polyoxyethylene lauryl ethers), ceteths (polyoxyethylene cetyl ethers), steareths (polyoxyethylene stearyl ethers), beheneths (polyoxyethylene behenyl ethers), isosteareths (polyoxyethylene isostearyl ethers), and octyldodeceths (polyoxyethylene octyldodecyl ethers); polyoxyethylene alkyl phenyl ethers; castor oil and hydrogenated castor oil derivatives, such as polyoxyethylene hydrogenated castor oil, polyoxyethylene hydrogenated castor oil, polyoxyethylene hydrogenated castor oil monoisostearate, polyoxyethylene hydrogenated castor oil triisostearate, polyoxyethylene hydrogenated castor oil monopyroglutamic acid monoisostearate diester, and polyoxyethylene hydrogenated castor oil maleic acid; polyoxyethylene phytosterol; polyoxyethylene cholesterol; polyoxyethylene cholestanol; Polyoxyethylene lanolin; polyoxyethylene reduced lanolin; polyoxyethylene-polyoxypropylene cetyl ether, polyoxyethylene-polyoxypropylene 2-decyltetradecyl ether, polyoxyethylene-polyoxypropylene monobutyl ether, polyoxyethylene-polyoxypropylene hydrogenated lanolin, polyoxyethylene-polyoxypropylene glycerin ether, and other polyoxyethylene-polyoxypropylene alkyl ethers; polyoxyethylene-polyoxypropylene glycol; (poly)glycerin polyoxypropylene glycols, such as PPG-9 diglyceryl; glyceryl stearate, glyceryl isostearate, glyceryl palmitate, glyceryl myristate, glyceryl oleate, glyceryl coconut oil fatty acid, glyceryl monocottonseed fatty acid, glyceryl monoerucate, glyceryl sesquioleate, glyceryl α,α'-oleic acid pyroglutamate, glyceryl monostearate malate, and other glyceryl fatty acid partial esters;Polyglyceryl-2 stearate, 3, 4, 5, 6, 8, 10, polyglyceryl-6 distearate, 10, polyglyceryl-2 tristearate, polyglyceryl-10 deca stearate, polyglyceryl-2 isostearate, 3, 4, 5, 6, 8, 10, polyglyceryl-2 diisostearate (diglyceryl diisostearate), 3, 10, polyglyceryl-2 triisostearate, polyglyceryl-2 tetraisostearate, polyglyceryl-1 decaisostearate Polyglycerin fatty acid esters such as Polyglyceryl-2, 3, 4, 5, 6, 8, 10, Polyglyceryl-6 dioleate, Polyglyceryl-2 trioleate, and Polyglyceryl-10 decaoleate; ethylene glycol mono fatty acid esters such as ethylene glycol monostearate; propylene glycol mono fatty acid esters such as propylene glycol monostearate; pentaerythritol partial fatty acid esters; sorbitol partial fatty acid esters; maltitol partial fatty acid esters;

[0035] Maltitol ether; sorbitan fatty acid esters such as sorbitan monooleate, sorbitan monoisostearate, sorbitan monolaurate, sorbitan monopalmitate, sorbitan monostearate, sorbitan sesquioleate, sorbitan trioleate, diglycerol sorbitan penta-2-ethylhexyl acid, and diglycerol sorbitan tetra-2-ethylhexyl acid; partial esters of sugar derivatives such as sucrose fatty acid esters, methyl glucoside fatty acid esters, and trehalose undecylenate; alkylglucosides such as caprylyl glucoside. Cosides; alkyl polyglycosides; lanolin alcohol; reduced lanolin; polyoxyethylene fatty acid mono- and diesters such as polyoxyethylene distearate, polyethylene glycol diisostearate, polyoxyethylene monooleate, and polyoxyethylene dioleate; polyoxyethylene propylene glycol fatty acid esters; polyoxyethylene monooleates such as polyoxyethylene glycerin monostearate, polyoxyethylene glycerin monoisostearate, and polyoxyethylene glycerin triisostearate; Polyoxyethylene glycerin fatty acid esters; polyoxyethylene sorbitan fatty acid esters such as polyoxyethylene sorbitan monooleate, polyoxyethylene sorbitan monostearate, polyoxyethylene sorbitan monooleate, and polyoxyethylene sorbitan tetraoleate; polyoxyethylene sorbitol fatty acid esters such as polyoxyethylene sorbitol monolaurate, polyoxyethylene sorbitol monooleate, polyoxyethylene sorbitol pentaoleate, and polyoxyethylene sorbitol monostearate; polyoxyethylene methyl glucoside fatty acid esters; polyoxyethylene alkyl ether fatty acid esters; polyoxyethylene animal and vegetable oils and fats such as polyoxyethylene sorbitol beeswax; alkyl glyceryl ethers such as isostearyl glyceryl ether, chimyl alcohol, selachyl alcohol, and batyl alcohol; polyhydric alcohol alkyl ethers; polyoxyethylene alkylamines; tetrapolyoxyethylene-tetrapolyoxypropylene-ethylenediamine condensates; natural surfactants such as saponin and sophorolipids;Polyoxyethylene fatty acid amides; fatty acid alkanolamides such as coconut oil fatty acid monoethanolamide (cocamide MEA), coconut oil fatty acid diethanolamide (cocamide DEA), lauric acid monoethanolamide (lauramide MEA), lauric acid diethanolamide (lauramide DEA), lauric acid monoisopropanolamide (lauramide MIPA), palmitic acid monoethanolamide (palmitamide MEA), palmitic acid diethanolamide (palmitamide DEA), and coconut oil fatty acid methylethanolamide (cocamide methyl MEA); Alkyl dimethylamine oxides such as lauramine oxide, cocamine oxide, stearamine oxide, and behenamine oxide; alkyl ethoxydimethylamine oxide; polyoxyethylene alkyl mercaptan; silicone-based nonionic surfactants such as polyether-modified silicones such as dimethicone copolyol, polysiloxane-oxyalkylene copolymers, polyglycerin-modified silicones, and sugar-modified silicones; cationic surfactants such as behentrimonium chloride, steartrimonium chloride, cetrimonium chloride, lauryltrimonium chloride, and cetrimonium chloride. alkyltrimethylammonium chlorides such as stearyltrimonium bromide; dialkyldimethylammonium chlorides such as distearyldimonium chloride and dicocodimonium chloride; fatty acid amidoamines and their salts such as stearamidopropyl dimethylamine and stearamidoethyl diethylamine; alkyletheramines and their salts or quaternary salts such as stearoxypropyl dimethylamine; fatty acid amide type quaternary ammonium salts such as ethyl sulfate long chain branched fatty acid (12-31) aminopropylethyl dimethylammonium, ethyl sulfate lanolin fatty acid aminopropylethyl dimethylammonium; polyoxyethylene alkylamines and their salts or quaternary salts; alkylamine salts; fatty acid amide guanidinium salts; alkyletheramine monium salts; alkyltrialkylene glycol ammonium salts; benzalkonium salts; benzethonium salts; pyridinium salts such as cetylpyridinium chloride; imidazolinium salts; alkylisoquinolinium salts; dialkylmorphonium salts; polyamine fatty acid derivatives; aminopropyl dimethicone and amodimine Silicone-based cationic surfactants such as amino-modified silicones such as methicone, cation-modified silicones, cation-modified and polyether-modified silicones, and amino-modified and polyether-modified silicones; amphoteric surfactants include N-alkyl-N,N-dimethyl amino acid betaines such as lauryl betaine (lauryl dimethyl amino acetate betaine); fatty acid amidoalkyl-N,N-dimethyl amino acid betaines such as cocamidopropyl betaine and lauramidopropyl betaine; imidazoline-type betaines such as sodium cocoamphoacetate and sodium lauroamphoacetate;Alkyl sulfobetaines such as alkyldimethyltaurine; sulfate-type betaines such as alkyldimethylaminoethanol sulfate; phosphate-type betaines such as alkyldimethylaminoethanol phosphate; sphingophospholipids such as phosphatidylcholine, phosphatidylethanolamine, phosphatidylserine, and sphingomyelin; phospholipids such as lysolecithin, hydrogenated soybean phospholipid, partially hydrogenated soybean phospholipid, hydrogenated egg yolk phospholipid, partially hydrogenated egg yolk phospholipid, and hydroxylated lecithin; silicone-based amphoteric surfactants; and polymer surfactants such as polyvinyl alcohol, sodium alginate, starch derivatives, tragacanth gum, and acrylic acid / alkyl methacrylate copolymers; and various silicone-based surfactants are preferred.

[0036] Polymers, thickeners, and gelling agents include guar gum, locust bean gum, queen seed, carrageenan, galactan, gum arabic, tara gum, tamarind, furcellan, karaya gum, aoi, caragam, tragacanth gum, pectin, pectinic acid and its salts such as sodium salt, alginic acid and its salts such as sodium salt, mannan; starches such as rice, corn, potato, and wheat; xanthan gum, dextran, succinoglucan, curdlan, hyaluronic acid and its salts, xanthan gum, pullulan, gellan gum, chitin, chitosan, Agar, cassou extract, chondroitin sulfate, casein, collagen, gelatin, albumin; cellulose and its derivatives such as methylcellulose, ethylcellulose, hydroxyethylcellulose, hydroxypropylcellulose, carboxymethylcellulose and its sodium salts, methylhydroxypropylcellulose, sodium cellulose sulfate, dialkyldimethylammonium cellulose sulfate, crystalline cellulose, cellulose powder, etc.; starch such as soluble starch, carboxymethyl starch, methylhydroxypropyl starch, methyl starch, etc. Starch derivatives such as polyvinyl chloride, hydroxypropyltrimonium starch chloride, and corn starch aluminum octenylsuccinate; alginic acid derivatives such as sodium alginate and propylene glycol alginate; polyvinylpyrrolidone (PVP), polyvinyl alcohol (PVA), vinylpyrrolidone-vinyl alcohol copolymer, polyvinyl methyl ether; polyethylene glycol, polypropylene glycol, polyoxyethylene-polyoxypropylene copolymer; amphoteric methacrylate copolymers such as (methacryloyloxyethyl carboxybetaine / alkyl methacrylate) copolymer, (acrylates / stearyl acrylate / ethylamine oxide methacrylate) copolymer; (dimethicone / vinyl dimethicone) crosspolymer, (alkyl acrylate / diacetone acrylamide) copolymer, (alkyl acrylate / diacetone acrylamide) copolymer AMP; polyvinyl acetate partially saponified product, maleic acid copolymer; vinylpyrrolidone-dialkylaminoalkyl methacrylate copolymer; acrylic resin alkanolamine; polyester, water-dispersible polyester;Polyacrylamide; polyacrylic acid ester copolymers such as polyethyl acrylate, carboxyvinyl polymers, polyacrylic acid and its salts such as sodium salt, acrylic acid-methacrylic acid ester copolymers;

[0037] Acrylic acid / alkyl methacrylate copolymers;Cationized cellulose such as Polyquaternium-10;Diallyldimethylammonium chloride / acrylamide copolymers such as Polyquaternium-7;Acrylic acid / diallyldimethylammonium chloride copolymers such as Polyquaternium-22;Acrylic acid / diallyldimethylammonium chloride / acrylamide copolymers such as Polyquaternium-39;Acrylic acid / cationized methacrylate copolymers;Acrylic acid / cationized methacrylic acid amide copolymers;Acrylic acid / methyl acrylate / methacrylamidopropyltrimethylammonium chloride copolymers such as Polyquaternium-47;Methacrylic acid choline ester chloride polymers;Cationized oligosaccharides, cationic dextran, cationic polysaccharides such as guar hydroxypropyltrimonium chloride;Polyethyleneimine;Cationized polymers;2-methacryloyloxy groups such as Polyquaternium-51 Preferred examples of the polymer include diethylphosphorylcholine polymers and copolymers with butyl methacrylate copolymers, etc.; polymer emulsions such as acrylic resin emulsions, polyethyl acrylate emulsions, polyacrylic alkyl ester emulsions, polyvinyl acetate resin emulsions, natural rubber latex, and synthetic latex; nitrocellulose; polyurethanes and various copolymers; various silicones; various silicone-based copolymers such as acrylic-silicone graft copolymers; various fluorine-based polymers; 12-hydroxystearic acid and its salts; dextrin fatty acid esters such as dextrin palmitate and dextrin myristate; silicic anhydride, fumed silica (ultrafine silicic anhydride particles), aluminum magnesium silicate, sodium magnesium silicate, metal soaps, dialkyl phosphate metal salts, bentonite, hectorite, organically modified clay minerals, sucrose fatty acid esters, and fructooligosaccharide fatty acid esters.

[0038] Solvents and propellants include lower alcohols such as ethanol, 2-propanol (isopropyl alcohol), butanol, and isobutyl alcohol; glycols such as propylene glycol, 1,3-butylene glycol, diethylene glycol, dipropylene glycol, and isopentyl diol; diethylene glycol monoethyl ether (ethoxydiglycol), ethylene glycol monoethyl ether, ethylene glycol monobutyl ether, triethylene glycol monoethyl ether, diethylene glycol diethyl ether, diethylene glycol dibutyl ether, propylene glycol monoethyl ether, and diethylene glycol diethyl ether. Preferred examples of the propellant include glycol ethers such as propylene glycol monoethyl ether; glycol ether esters such as ethylene glycol monoethyl ether acetate, diethylene glycol monoethyl ether acetate, and propylene glycol monoethyl ether acetate; glycol esters such as diethoxyethyl succinate and ethylene glycol disuccinate; benzyl alcohol, benzyloxyethanol, propylene carbonate, dialkyl carbonate, acetone, ethyl acetate, N-methylpyrrolidone; toluene; fluorocarbons, next-generation fluorocarbons; LPG, dimethyl ether, and carbon dioxide gas.

[0039] The antioxidants preferably include tocopherol derivatives such as tocopherol (vitamin E) and tocopherol acetate; BHT, BHA; gallic acid derivatives such as propyl gallate; vitamin C (ascorbic acid) and / or its derivatives; erythorbic acid and its derivatives; sulfites such as sodium sulfite; hydrogen sulfites such as sodium hydrogen sulfite; thiosulfates such as sodium thiosulfate; metabisulfites; thiotaurine, hypotaurine; thioglycerol, thiourea, thioglycolic acid, and cysteine ​​hydrochloride. The reducing agents preferably include thioglycolic acid, cysteine, and cysteamine. The oxidizing agents preferably include hydrogen peroxide, ammonium persulfate, sodium bromate, and percarbonate.

[0040] Examples of preservatives and antibacterial agents other than the normal flora antibacterial agent of the present invention include hydroxybenzoic acids and their salts or esters, such as methylparaben, ethylparaben, propylparaben, and butylparaben; salicylic acid; sodium benzoate; phenoxyethanol; 1,2-diols, such as 1,2-pentanediol and 1,2-hexanediol; isothiazolinone derivatives, such as methylchloroisothiazolinone and methylisothiazolinone; imidazolinium urea; dehydroacetic acid and its salts; phenols; and halogenated bisphenols, such as triclosan. Preferred examples of the antibacterial agent include phenols, acid amides, and quaternary ammonium salts; trichlorocarbanide, zinc pyrithione, benzalkonium chloride, benzethonium chloride, sorbic acid, chlorhexidine, chlorhexidine gluconate, halocarban, hexachlorophene, and hinokitiol; other phenols such as phenol, isopropylphenol, cresol, thymol, parachlorophenol, phenylphenol, and sodium phenylphenol; phenylethyl alcohol, photosensitive elements, antibacterial zeolites, and silver ions. Preferred examples of the chelating agent include edetates (ethylenediaminetetraacetates) such as EDTA, EDTA2Na, EDTA3Na, and EDTA4Na; hydroxyethylethylenediaminetriacetates such as HEDTA3Na; pentetates (diethylenetriaminepentaacetate); phytic acid; phosphonic acids such as etidronic acid and salts thereof such as their sodium salts; sodium oxalate; polyamino acids such as polyaspartic acid and polyglutamic acid; sodium polyphosphate, sodium metaphosphate, phosphoric acid; sodium citrate, citric acid, alanine, dihydroxyethylglycine, gluconic acid, ascorbic acid, succinic acid, and tartaric acid.

[0041] Preferred examples of the pH adjuster, acid, or alkali include citric acid, sodium citrate, lactic acid, sodium lactate, glycolic acid, succinic acid, acetic acid, sodium acetate, malic acid, tartaric acid, fumaric acid, phosphoric acid, hydrochloric acid, sulfuric acid, monoethanolamine, diethanolamine, triethanolamine, isopropanolamine, triisopropanolamine, 2-amino-2-methyl-1,3-propanediol, 2-amino-2-hydroxymethyl-1,3-propanediol, arginine, sodium hydroxide, potassium hydroxide, aqueous ammonia, guanidine carbonate, and ammonium carbonate. Examples of powders include mica, talc, kaolin, sericite, montmorillonite, kaolinite, mica, muscovite, phlogopite, synthetic mica, red mica, biotite, permiculite, magnesium carbonate, calcium carbonate, aluminum silicate, barium silicate, calcium silicate, magnesium silicate, strontium silicate, tungstate metal salts, magnesium, zeolite, barium sulfate, calcined calcium sulfate, calcium phosphate, fluorapatite, hydroxyapatite, ceramic powder, bentonite, smectite, clay, mud, metal soap (e.g. zinc myristate, calcium palmitate, aluminum stearate), calcium carbonate, red iron oxide, yellow iron oxide, black iron oxide, ultramarine, Prussian blue, carbon black, titanium oxide, fine and ultrafine titanium oxide, zinc oxide, fine and ultrafine zinc oxide, alumina, silica, fumed silica (ultrafine silicic anhydride), titanium mica. Preferred examples of the inorganic powders include inorganic powders of various sizes and shapes, such as fish scale foil, boron nitride, photochromic pigments, synthetic fluorine-containing mica, fine particle composite powders, gold, and aluminum, and inorganic powders which have been treated with silicones such as hydrogen silicone and cyclic hydrogen silicone, or other silanes, or various surface treatment agents such as titanium coupling agents to make them hydrophobic or hydrophilic; organic powders of various sizes and shapes, such as starch, cellulose, nylon powder, polyethylene powder, polymethyl methacrylate powder, polystyrene powder, styrene-acrylic acid copolymer resin powder, polyester powder, benzoguanamine resin powder, polyethylene terephthalate-polymethyl methacrylate laminate powder, polyethylene terephthalate-aluminum-epoxy laminate powder, urethane powder, silicone powder, Teflon (registered trademark) powder, and surface-treated powders; and organic-inorganic composite powders.Preferred examples of the inorganic salts include sodium chloride-containing salts such as table salt, ordinary salt, rock salt, sea salt, and natural salt; potassium chloride, aluminum chloride, calcium chloride, magnesium chloride, bittern, zinc chloride, ammonium chloride; sodium sulfate, aluminum sulfate, aluminum / potassium sulfate (alum), aluminum / ammonium sulfate, barium sulfate, calcium sulfate, potassium sulfate, magnesium sulfate, zinc sulfate, ferrous sulfate, and copper sulfate; and sodium phosphates such as 1Na / 2Na / 3Na phosphate, potassium phosphates, calcium phosphates, and magnesium phosphates.

[0042] Examples of ultraviolet absorbents include benzoic acid-based ultraviolet absorbents such as para-aminobenzoic acid, para-aminobenzoic acid monoglycerin ester, N,N-dipropoxy para-aminobenzoic acid ethyl ester, N,N-diethoxy para-aminobenzoic acid ethyl ester, N,N-dimethyl para-aminobenzoic acid ethyl ester, N,N-dimethyl para-aminobenzoic acid butyl ester, and N,N-dimethyl para-aminobenzoic acid ethyl ester; anthranilic acid-based ultraviolet absorbents such as homomenthyl-N-acetylanthranilate; salicylic acid and its sodium salts, amyl salicylate, menthyl salicylate, homomenthyl salicylate, octyl salicylate, phenyl salicylate, benzyl salicylate, and p-isopropanol phenyl salicylate; octyl cinnamate, ethyl-4-isopropyl Cinnamic acid-based UV absorbers such as cinnamate, methyl-2,5-diisopropylcinnamate, ethyl-2,4-diisopropylcinnamate, methyl-2,4-diisopropylcinnamate, propyl-p-methoxycinnamate, isopropyl-p-methoxycinnamate, isoamyl-p-methoxycinnamate, 2-ethylhexyl p-methoxycinnamate (octyl paramethoxycinnamate), 2-ethoxyethyl-p-methoxycinnamate (cinoxate), cyclohexyl-p-methoxycinnamate, ethyl-α-cyano-β-phenylcinnamate, 2-ethylhexyl α-cyano-β-phenylcinnamate (octocurine), glyceryl mono-2-ethylhexanoyl-di-paramethoxycinnamate, ferulic acid and its derivatives; 2,4-dihydroxybenzophenone, 2,2'- Dihydroxy-4-methoxybenzophenone, 2,2'-dihydroxy-4,4'-dimethoxybenzophenone, 2,2',4,4'-tetrahydroxybenzophenone, 2-hydroxy-4-methoxybenzophenone (oxybenzone-3), 2-hydroxy-4-methoxy-4'-methylbenzophenone, 2-hydroxy-4-methoxybenzophenone Benzophenone-based UV absorbers such as 5-phenylbenzophenone, 4-phenylbenzophenone, 2-ethylhexyl-4'-phenyl-benzophenone-2-carboxylate, 2-hydroxy-4-n-octoxybenzophenone, and 4-hydroxy-3-carboxybenzophenone; 3-(4'-methylbenzylidene)-d,l-camphor, 3-benzylidene-d,l-camphor; 2-phenyl-5-methylbenzoxazole; 2,2'-hydroxy-5-methylphenylbenzoxazole Triazole;2-(2'-hydroxy-5'-t-octylphenyl)benzotriazole;2-(2'-hydroxy-5'-methylphenylbenzotriazole;Dibenzalazine;Dianisoylmethane;5-(3,3-dimethyl-2-norbornylidene)-3-pentan-2-one;Dibenzoylmethane derivatives such as 4-t-butylmethoxydibenzoylmethane;Octyltriazone;Urocanic acid derivatives such as urocanic acid and ethyl urocanate;2-(2'-hydroxy-5'-methyl Preferred examples thereof include hydantoin derivatives such as 1-(3,4-dimethoxyphenyl)-4,4-dimethyl-1,3-pentanedione, dimethoxybenzylidene dioxoimidazolidinepropionate 2-ethylhexyl, phenylbenzimidazolazole sulfonic acid, terephthalidenedicamphor sulfonic acid, drometrizole trisiloxane, methyl anthranilate, rutin and its derivatives, and oryzanol and its derivatives.

[0043] Preferred examples of the whitening agent include hydroquinone glycosides and esters thereof, such as arbutin and α-arbutin; ascorbic acid, ascorbic acid phosphate salts, such as sodium ascorbic acid phosphate and magnesium ascorbic acid phosphate, ascorbic acid fatty acid esters, such as ascorbic acid tetraisopalmitate, ascorbic acid alkyl ethers, such as ascorbic acid ethyl ether, ascorbic acid glucosides and fatty acid esters thereof, such as ascorbic acid sulfate and tocopheryl ascorbyl phosphate; and plant extracts, such as kojic acid, ellagic acid, tranexamic acid and derivatives thereof, ferulic acid and derivatives thereof, placenta extract, glutathione, oryzanol, butylresorcinol, oil-soluble chamomilla extract, oil-soluble licorice extract, Nishikawa willow extract, and Saxifraga saxifrage extract.

[0044] Vitamins and their derivatives include vitamin A such as retinol, retinol acetate, and retinol palmitate; vitamin B such as thiamine hydrochloride, thiamine sulfate, riboflavin, riboflavin acetate, pyridoxine hydrochloride, pyridoxine dioctanoate, pyridoxine dipalmitate, flavin adenine dinucleotide, cyanocobalamin, folic acids, nicotinic acids such as nicotinamide and benzyl nicotinate, and choline; vitamin C such as ascorbic acid and its sodium salts; vitamin D; vitamin E such as α-, β-, γ-, and δ-tocopherol; other vitamins such as pantothenic acid and biotin; and vitamin B such as sodium ascorbic acid phosphate and magnesium ascorbic acid phosphate. Preferred examples of the compound include ascorbic acid phosphate salts, ascorbic acid fatty acid esters such as ascorbic acid tetraisopalmitate, ascorbyl stearate, ascorbyl palmitate, ascorbyl dipalmitate, etc., ascorbic acid alkyl ethers such as ascorbic acid ethyl ether, ascorbic acid glucoside and its fatty acid esters such as ascorbic acid-2-glucoside, and ascorbic acid derivatives such as tocopheryl ascorbyl phosphate; vitamin derivatives such as tocopherol nicotinate, tocopherol acetate, tocopherol linoleate, tocopherol ferulate, tocopherol phosphate, etc., tocotrienol, and various other vitamin derivatives.

[0045] Preferred examples of the anti-inflammatory agent include glycyrrhizic acid and its derivatives, glycyrrhetinic acid derivatives, salicylic acid derivatives, hinokitiol, guaiazulene, allantoin, indomethacin, zinc oxide, hydrocortisone acetate, prednisone, diphedramine hydrochloride, chlorpheniramine maleate; and plant extracts such as peach leaf extract and mugwort leaf extract.

[0046] Preferred examples of hair growth agents, blood circulation promoters, and stimulants include plant extracts and tinctures such as Swertia japonica extract, Capsicum tincture, Ginger tincture, Ginger extract, and Cantharis tincture; capsaicin, nonylic acid valenylamide, zingerone, ichthammol, tannic acid, borneol, cyclandelate, cinnarizine, tolazoline, acetylcholine, verapamil, cepharanthine, γ-oryzanol, cepharanthine, vitamin E, and derivatives such as tocopherol nicotinate and tocopherol acetate, γ-oryzanol, nicotinic acid, and derivatives such as nicotinamide, nicotinic acid benzyl ester, inositol hexanicotinate, and nicotine alcohol, allantoin, photosensitizer 301, photosensitizer 401, capronium chloride, pentadecanoic acid monoglyceride, flavanonol derivatives, stigmasterol or stigmastanol and its glycosides, and minoxidil. Hormones include estradiol, estrone, ethinyl estradiol, and cholestrol. Preferred examples include thizone, hydrocortisone, prednisone, and the like.

[0047] Other medicinal agents such as anti-wrinkle agents, anti-aging agents, tightening agents, cooling agents, warming agents, wound healing promoters, irritation relief agents, analgesics, and cell activators include retinols, retinoic acids, and tocopheryl retinoate; lactic acid, glycolic acid, gluconic acid, fruit acids, salicylic acid, and their derivatives such as glycosides and esters; α- or β-hydroxy acids and their derivatives such as hydroxycapric acid, long-chain α-hydroxy fatty acid, and long-chain α-hydroxy fatty acid cholesteryl; γ-aminobutyric acid, γ-amino-β-hydroxybutyric acid; carnitine; creatine; ceramides; sphingosines; caffeine, xanthine, and their derivatives; and anti-inflammatory agents such as coenzyme Q10, carotene, lycopene, astaxanthin, and α-lipoic acid. Preferred examples of such substances include oxidizing and active oxygen scavengers; catechins; flavones such as quercetin; isoflavones; gallic acid and ester sugar derivatives; polyphenols such as tannin, sesamin, protoanthocyanidin, chlorogenic acid, apple polyphenol, etc.; rutin and glycoside derivatives; hesperidin and glycoside derivatives; lignan glycosides; licorice extract-related substances such as glabridin, glabrene, liquiritin, and isoliquiritin; lactoferrin; shogaol, gingerol; fragrance substances and their derivatives such as menthol, camphor, and cedrol; capsaicin, vanillin, and derivatives; insect repellents such as diethyltoluamide; and complexes of physiologically active substances and cyclodextrins.

[0048] Plant, animal and microbial extracts include iris extract, angelica extract, asparagus extract, avocado extract, amacha extract, almond extract, althea extract, arnica extract, aloe extract, apricot extract, apricot kernel extract, ginkgo extract, inchiko extract, fennel extract, turmeric extract, oolong tea extract, uva-ursi extract, star anise extract, echinacea leaf extract, enmeiso extract, scutellaria extract, phellodendron bark extract, coptis extract, barley extract, ginseng extract, hypericum extract, and odendritic cellulite extract. Kosou extract, Ononis extract, Dutch mustard extract, Orange extract, Dried seawater, Seaweed extract, Oyster leaf extract, Kakyoku extract, Hydrolyzed elastin, Hydrolyzed wheat powder, Hydrolyzed silk, Pueraria lobata extract, Chamomilla extract, Oil-soluble Chamomilla extract, Carrot extract, Artemisia capillaris extract, Oat extract, Karkade extract, Licorice extract, Oil-soluble Licorice extract, Kiwi extract, Kiou extract, Jew's ear extract, Cinchona extract, Cucumber extract, Paulownia leaf extract, Guanosine, Guava extract, Sophora root extract, Gardenia extract, Sasa kumamoto extract , Sophora flavescens extract, walnut extract, chestnut extract, grapefruit extract, clematis extract, black rice extract, brown sugar extract, black vinegar, chlorella extract, mulberry extract, gentian extract, geranium extract, black tea extract, yeast extract, magnolia bark extract, coffee extract, burdock extract, rice extract, fermented rice extract, fermented rice bran extract, rice germ oil, comfrey extract, collagen, cowberry extract, Chinese laurel extract, bupleurum extract, umbilical cord extract, umbilical cord extract, saffron extract, salvia extract, soapwort extract, bamboo grass extract, hawthorn extract, Chinese hawthorn extract , Japanese pepper extract, shiitake mushroom extract, rehmannia extract, lithospermum extract, perilla extract, linden extract, meadowsweet extract, jatoba extract, peony extract, ginger extract, calamus root extract, white birch extract, white wood ear extract, horsetail extract, stevia extract, stevia fermentation product, Nishikawa willow extract, ivy extract, hawthorn extract, elderberry extract, yarrow extract, peppermint extract, sage extract, mallow extract, cnidium rhizome extract, swertia britannica extract, sophora japonica extract, rhubarb extract,Soybean extract, Chinese laurel extract, thyme extract, dandelion extract, lichen extract, tea extract, clove extract, Imperata cylindrica extract, tangerine extract, tea tree oil, sweet tea extract, chili pepper extract, angelica extract, calendula extract, toad extract, spruce extract, dokudami extract, tomato extract, natto extract, carrot extract, garlic extract, wild rose extract, hibiscus extract, burdock extract, lotus extract, parsley extract, birch extract, honey, witch hazel extract, parietaria extract, yarrow extract, bisabolol, cypress extract, bifidobacteria extract, loquat extract, coltsfoot extract, butterbur bud extract, bupleurum extract, butcher's broom extract, grape extract, grape seed extract Preferred examples of the extract include whiting, propolis, loofah extract, safflower extract, peppermint extract, linden extract, peony extract, hop extract, squid extract, pine extract, horse chestnut extract, skunk cabbage extract, soapberry extract, melissa extract, mozuku extract, peach extract, cornflower extract, eucalyptus extract, saxifrage extract, yuzu extract, lily extract, coix seed extract, mugwort extract, lavender extract, green tea extract, eggshell membrane extract, apple extract, rooibos tea extract, lychee extract, lettuce extract, lemon extract, forsythia extract, astragalus extract, rose extract, rosemary extract, Roman chamomile extract, royal jelly extract, and burnet extract.

[0049] Examples of antipruritic agents include diphenhydramine hydrochloride, chlorpheniramine maleate, camphor, and substance-P inhibitors. Examples of keratin peeling and dissolving agents include salicylic acid, sulfur, resorcin, selenium sulfide, and pyridoxine. Examples of antiperspirants include aluminum chlorohydrate, aluminum chloride, zinc oxide, and zinc paraphenolsulfonate. Examples of cooling agents include menthol and methyl salicylate. Examples of astringents include citric acid, tartaric acid, lactic acid, aluminum potassium sulfate, and tannic acid. Examples of enzymes include superoxide dismutase, catalase, lysozyme chloride, lipase, papain, pancreatin, and protease. Examples of nucleic acids include ribonucleic acid and its salts, deoxyribonucleic acid and its salts, and adenosine triphosphate disodium.

[0050] Fragrances include acetyl cedrene, amyl cinnamaldehyde, allyl amyl glycolate, β-ionone, isoe-super, isobutylquinoline, iris oil, iron, indole, ylang-ylang oil, undecanal, undecenal, γ-undecalactone, estragole, eugenol, oakmoss, opoponax resinoid, orange oil, eugenol, aurantiol, galacsolid, carvacrol, L-carvone, camphor, canon, carrot seed oil, clove oil, methyl cinnamate, geraniol, geranyl nitrile, isobornyl acetate, geranyl acetate, dimethylbenzylcarbinyl acetate, styralyl acetate, cedryl acetate, terpinel acetate, pt-butylcyclohexyl acetate. , vetiveryl acetate, benzyl acetate, linalyl acetate, isopentyl salicylate, benzyl salicylate, sandalwood oil, santalol, cyclamen aldehyde, cyclopentadecanolide, methyl dihydrojasmonate, dihydromyrcenol, jasmine absolute, jasmine lactone, cis-jasmone, citral, citronenol, citronellal, cinnamon bark oil, 1,8-cineole, cinnamaldehyde, styrax resinoids, cedarwood oil, cedrene, cedrol, celery seed oil, thyme oil, damascone, damascenone, thymol, tuberose absolute, decanal, decalactone, terpineol, gamma-terpinene, triplal, nerol, nonanal, 2,6-Nonadienol, Nonalactone, Patchouli Alcohol, Vanilla Absolute, Vanillin, Basil Oil, Patchouli Oil, Hydroxycitronellal, Alpha-Pinene, Piperitone, Phenethyl Alcohol, Phenylacetaldehyde, Petitgrain Oil, Hexylcinnamaldehyde, cis-3-Hexenol, Balsam of Peru, Vetiver Oil, Vetiverol, Peppermint Oil, Pepper Oil, Heliotropin, Bergamot Oil, Benzyl Benzene Preferred examples of the synthetic and natural fragrances include maltitol, borneol, myrrhizinoid, musk ketone, methylnonylacetaldehyde, γ-methylionone, menthol, L-menthol, L-menthone, eucalyptus oil, β-ionone, lime oil, lavender oil, D-limonene, linalool, lyral, lilial, lemon oil, rose absolute, rose oxide, rose oil, rosemary oil, and various essential oils, as well as various blended fragrances.

[0051] Dyes, colorants, dyes and pigments include Brown No. 201, Black No. 401, Purple No. 201, Purple No. 401, Blue No. 1, Blue No. 2, Blue No. 201, Blue No. 202, Blue No. 203, Blue No. 204, Blue No. 205, Blue No. 403, Blue No. 404, Green No. 201, Green No. 202, Green No. 204, Green No. 205, Green No. 3, Green No. 401, Green No. 402, Red Color No. 102, Red No. 104-1, Red No. 105-1, Red No. 106, Red No. 2, Red No. 201, Red No. 202, Red No. 203, Red No. 204, Red No. 205, Red No. 206, Red No. 207, Red No. 208, Red No. 213, Red No. 214, Red No. 215, Red No. 218, Red No. 219, Red No. 220, Red No. 221, Red No. 223, Red No. 22 No. 5, Red No. 226, Red No. 227, Red No. 228, Red No. 230-1, Red No. 230-2, Red No. 231, Red No. 232, Red No. 3, Red No. 401, Red No. 404, Red Color No. 405, Red No. 501, Red No. 502, Red No. 503, Red No. 504, Red No. 505, Red No. 506, Orange No. 201, Orange No. 203, Orange No. 204, Orange No. 205, Legal dyes such as Orange No. 206, Orange No. 207, Orange No. 401, Orange No. 402, Orange No. 403, Yellow No. 201, Yellow No. 202-1, Yellow No. 202-2, Yellow No. 203, Yellow No. 204, Yellow No. 205, Yellow No. 4, Yellow No. 401, Yellow No. 402, Yellow No. 403-1, Yellow No. 404, Yellow No. 405, Yellow No. 406, Yellow No. 407, Yellow No. 5, etc.;Other acid dyes such as Acid Red 14;

[0052] Basic dyes such as Arianor Sienna Brown, Arianor Madder Red, Arianor Steel Blue, Arianor Straw Yellow; HC Yellow 2, HC Yellow5, HC Red 3, 4-hydroxypropylamino-3-nitrophenol, N,N'bis(2-hydroxyethyl)-2-nitro-p-phenylenediamine, HC Blue 2, Basic Blue 26 and other nitro dyes; disperse dyes; inorganic white pigments such as titanium dioxide and zinc oxide; inorganic red pigments such as iron oxide (red ocher) and iron titanate; inorganic brown pigments such as gamma-iron oxide; inorganic yellow pigments such as yellow iron oxide and ocher; inorganic black pigments such as black iron oxide and low-order titanium oxide; inorganic purple pigments such as mango violet and cobalt violet; inorganic green pigments such as chromium oxide, chromium hydroxide, and cobalt titanate; inorganic blue pigments such as ultramarine and Prussian blue; pearl pigments such as titanium oxide coated mica, titanium oxide coated bismuth oxychloride, titanium oxide coated talc, colored titanium oxide coated mica, bismuth oxychloride, and fish scale foil; metal powder pigments such as aluminum powder, copper powder, and gold; surface-treated inorganic and metal powder pigments; Red No. 201, Red No. 202, Red No. 204, Red No. 205, Red No. 2 Organic pigments such as zirconium, barium or aluminum lakes, such as No. 20, Red 226, Red 228, Red 405, Orange 203, Orange 204, Yellow 205, Yellow 401, Blue 404, Red 3, Red 104, Red 106, Red 227, Red 230, Red 401, Red 505, Orange 205, Yellow 4, Yellow 5, Yellow 202, Yellow 203, Green 3, Blue 1, etc. Pigments; surface-treated organic pigments; anthraquinones such as astaxanthin and alizarin, anthocyanidin, β-carotene, catenal, capsanthin, chalcone, carthamine, quercetin, crocin, chlorophyll, curcumin, naphthoquinones such as cochineal and shikonin, bixin, flavones, betacyanidin, henna, hemoglobin, lycopene, riboflavin, rutin, and other natural pigments and dyes;Preferred examples include oxidation dye intermediates and couplers such as p-phenylenediamine, toluene-2,5-diamine, o-, m-, or p-aminophenol, m-phenylenediamine, 5-amino-2-methylphenol, resorcin, 1-naphthol, 2,6-diaminopyridine, and salts thereof; autoxidation dyes such as indoline; and dihydroxyacetone.

[0053] Examples of water that can be preferably mentioned include tap water, purified water, hard water, soft water, natural water, deep sea water, electrolytic alkaline ionized water, electrolytic acidic ionized water, ionized water, and cluster water. In addition to these, known cosmetic ingredients, pharmaceutical ingredients, and food ingredients, such as ingredients listed in the Cosmetic Raw Materials Standards, Cosmetic Type Ingredient Standards, Japan Cosmetic Industry Association Ingredient Labeling Name List, INCI Dictionary (The International Cosmetic Ingredient Dictionary and Handbook), Quasi-drug Raw Materials Standards, Japanese Pharmacopoeia, Pharmaceutical Additives Standards, and Food Additives Official Specification, and ingredients listed in Japanese and foreign patent gazettes and patent publications (including published gazettes and republications) that fall under the International Patent Classification IPC A61K7, can be contained in known combinations, blending ratios, and blending amounts.

[0054] [Uses of the disclosed resident flora antibacterial agent] The resident flora antibacterial agent of the present disclosure can exhibit high antibacterial properties in cosmetic applications, and can be preferably used as a resident flora antibacterial agent for use in skin cosmetics, topical skin preparations, hair cosmetics, and the like. Cosmetics in this disclosure refer to cosmetics, quasi-drugs, and pharmaceuticals that are applied directly to the skin of the human body, and cosmetics include skin cosmetics, skin topical preparations, skin cleansing agents, hair cosmetics, hair topical preparations, hair cleansing agents, and the like. A resident bacteria antibacterial agent in this disclosure is an agent that is used for the above-mentioned applications and has antibacterial properties. Antibacterial properties refer to performance such as bactericidal (killing microorganisms), bacteriostatic (suppressing the growth of microorganisms), sterilization, disinfection, bacteriostatic, germicidal, and mold-proofing, and the microorganisms that are the subject of this disclosure are resident bacteria. Resident bacteria are the various bacteria listed as resident bacteria in this disclosure above. In particular, since the resident flora antibacterial agent of the present disclosure exhibits antibacterial activity against resident skin flora at low concentrations, it is useful in the following basic cosmetics, makeup cosmetics, body cosmetics, hair cosmetics, and topical skin preparations. Basic cosmetics include lotions such as softening lotion, astringent lotion, cleansing lotion, and multi-layered lotion; emulsions such as emollient lotion, moisture lotion, milky lotion, nourishing lotion, nourishing milk, skin moisture, moisturizing emulsion, massage lotion, cleansing lotion, protective emulsion, sun protect, sun protector, UV care milk, sunscreen, makeup lotion, exfoliating smoother, elbow lotion, hand lotion, and body lotion; emollient cream, nourishing cream, nourishing cream, vanishing cream, moisture cream, night cream, massage cream, cleansing cream, makeup cream, base cream, pre-makeup cream, etc. Preferred examples of the cosmetic products include creams such as moisturizing cream, sunscreen cream, suntan cream, hair removal cream, deodorant cream, shaving cream, and exfoliating cream; gels such as moisture gel; essences such as moisturizing essence, whitening essence, and UV protection essence; liposome cosmetics such as liposome beauty serum and liposome lotion; packs and masks such as peel-off packs, powder packs, washing packs, oil packs, and cleansing masks; facial cleansers such as cleansing foam, cleansing cream, cleansing milk, cleansing lotion, cleansing gel, cleansing oil, cleansing mask, powder, and facial cleansing powder; and soaps such as cosmetic soap, transparent soap, medicated soap, liquid soap, shaving soap, and synthetic cosmetic soap.

[0055] Preferred examples of makeup cosmetics include face powders, foundations, lipsticks, lip glosses, blushers, eyeliners, mascaras, eye shadows, eyebrow pencils, nail enamels, enamel removers, and nail treatments. Preferred examples of fragrance cosmetics include perfumes, perfumes, parfums, eau de parfum, eau de toilette, eau de cologne, perfume pastes, fragrance powders, perfumed soaps, body lotions, and bath oils. Preferred examples of body cosmetics include body cleansing agents such as body shampoo; deodorant cosmetics such as deodorant lotions, deodorant powders, deodorant sprays, and deodorant sticks; bleaches, depilatories, and hair removers; bath additives; and insect repellents such as insect repellent sprays.

[0056] Preferred examples of hair cosmetics include shampoos such as oil shampoo, cream shampoo, conditioning shampoo, anti-dandruff shampoo, hair color shampoo, and rinse-integrated shampoo; rinses, treatments, hair packs, color lotions, split-end coats, permanent wave agents, straight perm agents, oxidative hair dyes, hair bleach, hair color pre-treatments, hair color after-treatments, perm pre-treatments, perm after-treatments, hair manicures, hair tonics, and hair growth agents.

[0057] As an external preparation for the skin, it can be used in the form of an ointment, patch, lotion, liniment, liquid application agent, etc. It can also be used as an oral cosmetic material such as toothpaste and mouthwash.

[0058] Preferred dosage forms of the resident flora antibacterial agent of the present disclosure include emulsion-type cosmetics such as oil-in-water (O / W) type, water-in-oil (W / O) type, W / O / W type, and O / W / O type, oil-based cosmetics, solid cosmetics, liquid cosmetics, paste cosmetics, stick-type cosmetics, volatile oil-type cosmetics, powder cosmetics, jelly-type cosmetics, gel-type cosmetics, paste-type cosmetics, emulsified polymer-type cosmetics, sheet-type cosmetics, mist-type cosmetics, and spray-type cosmetics. The indigenous bacteria antibacterial agent of the present disclosure can be particularly preferably used in cosmetics that are applied directly to the skin, and in shampoos, facial cleansers, and the like that are applied directly to the skin.

[0059] [Method of using the copolymer of the present disclosure] The copolymer of the present disclosure has excellent antibacterial properties against resident bacteria, and can be preferably used as an antibacterial agent against resident bacteria. The copolymer of the present disclosure can be preferably incorporated into cosmetics. The copolymer of the present disclosure or the resident bacteria antibacterial agent of the present disclosure is not particularly limited, but it is preferable to incorporate the copolymer of the present disclosure into cosmetics so that it is, for example, 0.01 ppm or more and 5% or less, more preferably 0.1 ppm or more and 1% or less, and most preferably 1 ppm or more and 1000 ppm or less. EXAMPLES

[0060] The present invention will be described in more detail below with reference to examples, but the present invention is not limited to these examples. In addition, unless otherwise specified, "parts" means "parts by mass" and "%" means "% by mass". [Production Example 1] In a separable glass flask equipped with a thermometer, a reflux condenser, and a stirrer, 29.4 g of pure water and 100.0 g of 1,3-butanediol (KH Neochem Co., Ltd.) were charged, and the temperature was raised to 90° C. under stirring. Next, in a polymerization reaction system at a constant temperature of 80° C. under stirring, a monomer solution 1 consisting of 65.0 g of 2-(dimethylamino)ethyl methacrylate (N,N-dimethylaminoethyl methacrylate) (Kyoeisha Chemical Co., Ltd., hereinafter referred to as DAM), a monomer solution 2 consisting of 35.0 g of ethyl methacrylate (Kyoeisha Chemical Co., Ltd., hereinafter referred to as EMA), and an initiator aqueous solution consisting of 18.3 g of a 10% aqueous solution of 2,2'-azobis(2-methylpropionamidine) dihydrochloride (Fujifilm Wako Pure Chemical Co., Ltd., hereinafter referred to as V-50) were dropped from separate dropping nozzles. Regarding the start time of dropping, the monomer solutions 1 and 2 and the aqueous initiator solution were dropped at the same time, and the monomer solution 1 was dropped for 180 minutes, the monomer solution 2 for 170 minutes, and the aqueous initiator solution for 210 minutes. After the completion of all the dropping, the reaction solution was kept at 80°C for another 30 minutes to mature, and the polymerization was completed. After that, 55.2g of pure water and 205.5g of 1,3-butanediol were added to obtain copolymer 1. The solid content of the obtained copolymer was 19.7%, the pH was 9.0, and the weight average molecular weight was 34,000. [Production Example 2] 90.0 g of 1,3-butanediol and 22.6 g of water were charged into a separable glass flask equipped with a thermometer, a reflux condenser, and a stirrer, and the temperature was raised to 80° C. under stirring. Next, monomer solution 1 consisting of 117.5 g of DAM, monomer solution 2 consisting of 13.5 g of EMA, monomer solution 3 consisting of 23.2 g of an 18% aqueous acrylic acid solution (manufactured by Fujifilm Wako Pure Chemical Industries, Ltd.), and an aqueous initiator solution consisting of 22.6 g of a 10% aqueous solution of V-50 were dropped from separate dropping nozzles into the polymerization reaction system kept at a constant temperature of 80° C. under stirring. The monomer solutions 1 and 2 and the aqueous initiator solution were dropped at the same time, and the monomer solutions were dropped for 150 minutes, and the aqueous initiator solution for 180 minutes. After the entire dropwise addition was completed, the reaction solution was kept at 80°C for another 60 minutes to mature, and the polymerization was completed. After that, 53.9 g of pure water was added to obtain copolymer 1. The solid content of the obtained copolymer was 39.3%, pH was 9.0, and weight average molecular weight was 38,000.

[0061] Example 1 <Antibacterial test (Malassezia fungus)> Malassezia fungus (dandruff fungus, Malassezia furfurNBRC-656) provided by NBRC (National Biotechnology Center for Product Evaluation and Research) was streaked on chromoagar Malassezia medium (Kanto Chemical Co., Ltd.) and cultured at 35°C for 4 days without drying. The grown colonies were suspended in Butterfield's buffer solution to prepare 5 ml of a solution with OD660=1. Next, 10 ml of each of the aqueous solution containing copolymer 1 obtained in Production Example 1 and the aqueous solution containing antibacterial agent obtained in Production Example 2 was diluted to a specified concentration to prepare 10 ml of each aqueous solution. 0.1 ml of the bacterial solution of Malassezia fungus prepared above was added to each of these aqueous solutions. This was mixed by inversion and incubated at 25°C. After 4 hours and 4 days, a portion of each aqueous solution was sampled to prepare a dilution series, streaked on chromoagar Malassezia medium, cultured at 35°C for 4 days, and the number of remaining bacteria was counted. For comparison, zinc pyrithione (Comparative Example 1) and methylparaben (Comparative Example 2), which are often used as preservatives, were used and the same experiment was carried out. The results are shown in Table 1.

[0062] [Table 1] The results in Table 1 show that the polymer of the present disclosure has a remarkable effect against Malassezia fungus.

[0063] Example 2 <Antibacterial test (Acne bacteria)> Cutibacterium acnes NBRC-107605, provided by NBRC (National Institute of Technology and Evaluation, Biotechnology Center), was streaked onto GAM broth agar medium (Nissui Pharmaceutical Co., Ltd.), placed in an anaerobic chamber containing Anaeropack Kenki (Mitsubishi Gas Chemical Co., Ltd.), and cultured at 37°C for 4 days under anaerobic conditions. The formed colonies were suspended in Butterfield's buffer and diluted to 10 × 10 8 The bacterial solution was then diluted with GAM broth to a concentration of 10 × 10 6 The test solution was diluted to about 1 / mL. Next, the test aqueous solution was diluted in GAM broth medium by 2-fold increments to prepare a dilution series of medium containing copolymer 1 obtained in Production Example 1 and copolymer 2 obtained in Production Example 2. Then, 50 μL of the medium containing each concentration of antibacterial agent was added to a 96-well polystyrene plate. Next, 50 μL of the diluted bacterial solution prepared above was added to the dilution series of medium. Next, the 96-well polystyrene plate was placed in an anaerobic chamber containing Anaeropack Kenki and incubated at 37°C for 3 days under anaerobic conditions, and the minimum antibacterial agent concentration (ppm by mass) in the medium where no bacteria grew was determined as the minimum inhibitory concentration (MIC). The presence or absence of bacterial growth was judged by visual observation based on whether the turbidity increased. Zinc pyrithione (Comparative Example 1) and methylparaben (Comparative Example 2), which are often used as preservatives for cosmetics, were used for comparison. The results are shown in Table 2.

[0064] [Table 2] The results in Table 2 show that the polymer of the present disclosure has a significant effect against Propionibacterium acnes.

[0065] [Examples 3 and 4] <Adjusting shampoo formula> Copolymer 1 obtained in Production Example 1 and Copolymer 2 obtained in Production Example 2 were diluted with water while maintaining the pH at around 6 using a 10% by weight aqueous solution of citric acid (manufactured by Fujifilm Wako Pure Chemical Industries, Ltd.) to prepare 2% aqueous solutions (Tables 8 and 9). The components were blended as shown in Table 3 below to produce shampoo compositions according to the present disclosure.

[0066] [Table 3] The adjustment method is shown below. 1) After 1 to 4 were uniformly dissolved, 5 was added and mixed uniformly (80°C, 10 minutes). 2) 6 was added to 1) and dissolved uniformly (80℃, 5 minutes). 3) 2) was cooled to 40°C. 4) 7 to 9, which had been uniformly mixed in advance, were added to 3) and mixed uniformly. 5) 10, 11, 12, and 13 were added to 4) in this order and mixed uniformly. For the product names shown in Table 3, the products listed below were used. EDTA-Na: Chelate 2B-SD (manufactured by Chubu Chelate Co., Ltd.) Sodium benzoate: Sodium benzoate (manufactured by Fujifilm Wako Pure Chemical Industries, Ltd.) Glycerin: Concentrated glycerin for cosmetics (manufactured by Sakamoto Pharmaceutical Industry Co., Ltd.) Hydroxyethyl cellulose hydroxypropyltrimethylammonium chloride ether: Poise C-60H (Kao Corporation) Coconut oil fatty acid monoethanolamide: Amizol CME (Kawaken Fine Chemical Co., Ltd.) Coconut oil fatty acid amidopropyl carbobetaine: Amphitol 55AB (Kao Corporation) Alkyl (8-16) glucoside: Mydol 10 (Kao Corporation) Sodium polyoxyethylene lauryl ether acetate: Viewlite LCA-25F (manufactured by Sanyo Chemical Industries, Ltd.) Dimethyldiallylammonium chloride-acrylamide copolymer: MERQUAT550RR (manufactured by Lubrizol Japan, Inc.) 10% citric acid solution: (Fuso Chemical Co., Ltd.) The shampoo compositions of Examples 3 and 4 were stable without separation or precipitation even after being left to stand at room temperature for one month.

[0067] [Examples 5 and 6] <Adjusting the facial cleanser formula> Copolymer 1 obtained in Production Example 1 and Copolymer 2 obtained in Production Example 2 were used and blended as shown in Table 4 below to produce a facial cleansing foam composition according to the present disclosure.

[0068] [Table 4] The adjustment method is shown below. 1) Heat 1 to 9 to 80℃ and dissolve uniformly. 2) Heat 10 and 11 to 80℃ and dissolve uniformly. 3) Slowly add 2) to 1) and mix uniformly (80℃, 30 minutes). 4) Add 12 and 13 to 3) in that order, then slowly cool to 40°C. 5) Add 14 to 4) and mix uniformly. For the product names shown in Table 4, the products listed below were used. Lauric acid: Lunac L-98 (Kao Corporation) Myristic acid: Lunac MY-98 (Kao Corporation) Stearic acid: Lunac S-98 (Kao Corporation) Palmitic acid: Lunac P-95 (Kao Corporation) Glyceryl stearate: Rheodol MS-50 (Kao Corporation) Glycol distearate: NIKKOL Esthepearl 10V (manufactured by Nikko Chemicals Co., Ltd.) PEG-8: PEG#400 (NOF Corporation) Potassium hydroxide (85%): Fujifilm Wako Pure Chemical Industries, Ltd. The facial cleansing foam compositions of Examples 5 and 6 were stable without separation or precipitation even after being left to stand at room temperature for one month.

Claims

1. An antibacterial agent for normal skin bacteria comprising a copolymer, The copolymer has a structural unit (a) derived from an amino group-containing monomer and a structural unit (b) derived from a hydrophobic monomer, the structural unit (a) derived from the amino group-containing monomer being represented by the following general formula (1), the hydrophobic monomer has a solubility parameter of a homopolymer of 15 or less, and the skin resident flora is a fungus of the genus Malassezia and / or Propionibacterium acnes. 【Chemistry 1】 (In general formula (1), R1, R2, and R3 each independently represent a hydrogen atom or an organic group having 1 to 12 carbon atoms, R4 and R5 each independently represent a hydrogen atom or an alkyl group having 1 to 5 carbon atoms, and -X- represents -C(=O)-O-CH2CH2-. Note that the asterisk represents an atom contained in another structural unit of the same type or different type to which the structural unit represented by general formula (1) is bonded.)

2. An antibacterial agent for common skin bacteria as described in claim 1, characterized in that the structural unit (b) derived from the hydrophobic monomer contains at least one type of (meth)acrylic acid alkyl ester.

3. An antibacterial agent for skin resident bacteria as described in claim 1, wherein the structural unit (b) derived from the hydrophobic monomer includes a structural unit derived from ethyl (meth)acrylate.

4. An antibacterial agent for resident skin bacteria as described in claim 1, wherein the content of structural units (a) derived from the amino group monomer is 36% by mass or more and 65% by mass or less, relative to 100% by mass of structural units derived from all monomers constituting the copolymer, and the content of structural units (b) derived from the hydrophobic monomer is 35% by mass or more and 64% by mass or less, relative to 100% by mass of structural units derived from all monomers constituting the copolymer.

5. An antibacterial agent for common skin bacteria as described in claim 1, wherein the weight average molecular weight (Mw) of the copolymer is 4,000 or more and 800,000 or less.

6. A scalp or skin care product comprising the copolymer according to any one of claims 1 to 5.

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