Blood Purification Device

Abstract

To provide a blood purification device capable of using, a B agent stock solution used in a blood purification therapy step, as an alkali agent used in a fat removing cleaning step, as well as, capable of surely and smoothly performing the fat removing cleaning step.SOLUTION: A blood purification device comprises: a piping part comprising, a dialysate introduction line L1 and a drainage discharge line L2; a dual pump 1; and a control part 13 for executing a blood purification therapy step of feeding, to a dialyzer C, a dialysate made by diluting an A agent stock solution and a B agent stock solution to prescribed concentration, and a fat removing cleaning step of removing fat on the piping part through circulation of a sodium carbonate aqueous solution obtained by introducing the B agent stock solution to the piping part. The control part 13, while discharging carbon dioxide by a heating part 4 and a degassing part 5, executes a bicarbonate solution generation step of generating a prescribed capacity of the sodium carbonate aqueous solution, and then, executes the fat removing cleaning step using the sodium carbonate aqueous solution.SELECTED DRAWING: Figure 3

Description

[Technical field]

[0001] The present invention relates to a blood purification device that circulates a patient's blood extracorporeally through a blood purifier and a blood circuit to purify the blood. [Background technology]

[0002] A dialysis machine as a blood purification device used in dialysis treatment and the like usually has a piping section having a dialysate inlet line for introducing dialysis fluid into the blood purifier and a drainage discharge line for discharging drainage fluid from the blood purifier, and a fluid delivery section for delivering the dialysis fluid and drainage fluid in the piping section. The dialysis machine is configured by connecting a blood circuit for circulating the patient's blood extracorporeally to the blood purifier, and performs dialysis treatment (blood purification treatment) using the blood purifier while circulating the patient's blood extracorporeally through the blood circuit.

[0003] In such blood purification apparatuses, hygiene is maintained for a long period of time by periodically carrying out a degreasing step in which an alkaline agent such as sodium carbonate or sodium hypochlorite is introduced into the flow path of the piping and circulated to perform degreasing and cleaning. Conventionally, it has been proposed to generate an aqueous sodium carbonate solution by heating an undiluted solution of agent B used to prepare a dialysis fluid, and to use the resulting aqueous sodium carbonate solution as an alkaline agent circulated through the piping in the degreasing step (see, for example, Patent Document 1).

[0004] In this way, by heating the stock solution of agent B used to prepare dialysis fluid in dialysis treatment and using the resulting aqueous sodium carbonate solution as an alkaline agent to be circulated in the degreasing process, it is possible to reuse the stock solution of agent B remaining in dialysis treatment, thereby reducing the cost of using chemicals and the number of types of chemicals used in the degreasing process, thereby reducing the effort required for management. [Prior art documents] [Patent documents]

[0005] [Patent Document 1] JP 2018-118033 A Summary of the Invention [Problem to be solved by the invention]

[0006] However, in the above-mentioned conventional blood purification device, although the stock solution of agent B used in dialysis treatment (blood purification treatment process) can be reused as the alkaline agent (sodium carbonate aqueous solution) used in the degreasing and cleaning process, it is expected that carbon dioxide (CO2) generated when the stock solution of agent B is heated will remain in the piping, and there is a risk that the degreasing and cleaning process cannot be performed well. Also, when the stock solution of agent B is heated during the degreasing and cleaning process to generate an aqueous sodium carbonate solution and use it as an alkaline agent, there is a risk that the aqueous sodium carbonate solution will be insufficient and the degreasing and cleaning process will have to be interrupted.

[0007] The present invention has been made in consideration of the above circumstances, and aims to provide a blood purification apparatus which can reuse the stock solution of agent B used in the blood purification treatment process as the alkaline agent used in the degreasing and cleaning process, and which can perform the degreasing and cleaning process reliably and smoothly. [Means for solving the problem]

[0008] A blood purification apparatus according to one embodiment of the present invention is a blood purification apparatus which circulates a patient's blood extracorporeally through a blood purifier and a blood circuit to purify the blood, and which comprises: a piping section having a dialysate introduction line for introducing a dialysis fluid into the blood purifier and a drainage discharge line for discharging drainage from the blood purifier; a fluid delivery section for delivering the dialysis fluid and drainage from the piping section; a blood purification treatment step of delivering the dialysis fluid prepared by introducing and mixing an A agent stock solution and a B agent stock solution into the piping section and diluting them to a predetermined concentration to the blood purifier; The system is equipped with a control unit that executes a degreasing and cleaning process in which an aqueous bicarbonate solution is circulated through the piping section to perform a degreasing and cleaning process to remove grease from the piping section, a heating unit that heats the agent B stock solution introduced into the piping section, and a degassing unit that discharges carbon dioxide generated when the agent B stock solution is heated by the heating unit to the outside of the piping section, and the control unit executes a bicarbonate aqueous solution generation process in which a predetermined volume of bicarbonate aqueous solution is generated while discharging carbon dioxide using the heating unit and the degassing unit, and then executes the degreasing and cleaning process using the bicarbonate aqueous solution. Effect of the Invention

[0009] According to the present invention, after carrying out a bicarbonate aqueous solution generation process in which a predetermined volume of bicarbonate aqueous solution is generated while emitting carbon dioxide using a heating unit and a deaeration unit, a degreasing and cleaning process is carried out using the bicarbonate aqueous solution. Therefore, the stock solution of agent B used in the blood purification treatment process can be reused as the alkaline agent used in the degreasing and cleaning process, and the degreasing and cleaning process can be carried out reliably and smoothly. [Brief description of the drawings]

[0010] [Figure 1] FIG. 1 is a schematic diagram showing a blood purification device according to an embodiment of the present invention; [Diagram 2] FIG. 1 is a schematic diagram illustrating a blood purification treatment process performed by the blood purification device. [Diagram 3] FIG. 1 is a schematic diagram illustrating a bicarbonate aqueous solution production process performed in the blood purification device. [Figure 4]FIG. 1 is a schematic diagram illustrating a degreasing and washing process performed in the blood purification device. [Diagram 5] A flowchart showing the control by the control unit of the blood purification device. [Figure 6] FIG. 13 is a schematic diagram showing a portion that serves as both a heating unit and a degassing unit in a blood purification device according to another embodiment of the present invention. DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS

[0011] Hereinafter, an embodiment of the present invention will be described in detail with reference to the drawings. The blood purification device of this embodiment circulates a patient's blood extracorporeally through a blood purifier and a blood circuit to purify the blood. As shown in FIG. 1, the blood purification device is configured to include a blood circuit K having an arterial blood circuit K1 and a venous blood circuit K2, a dialyzer C as a blood purifier, a piping section having a dialysate inlet line L1 and a effluent discharge line L2, etc., a duplex pump 1 as a fluid delivery section, and a control section 13.

[0012] The arterial blood circuit K1 has a connector connected to its tip, through which an arterial puncture needle can be connected, and has a peristaltic blood pump and an arterial air trap chamber disposed midway. On the other hand, the venous blood circuit K2 has a connector connected to its tip, through which a venous puncture needle can be connected, and has a venous air trap chamber disposed midway.

[0013] The dialyzer C (blood purifier) ​​has a blood inlet C1 (blood inlet port), a blood outlet C2 (blood outlet port), a dialysate inlet C3 (dialysis fluid flow path inlet: dialysate inlet port), and a dialysate outlet C4 (dialysis fluid flow path outlet: dialysate outlet port) formed in its housing, of which the arterial blood circuit K1 is connected to the blood inlet C1, and the venous blood circuit K2 is connected to the blood outlet C2. The dialysate inlet C3 and the dialysate outlet C4 are connected to the dialysate introduction line L1 and the effluent discharge line L2, respectively.

[0014] A plurality of hollow fiber membranes (not shown) are housed in the dialyzer C, and these hollow fibers constitute a blood purification membrane for purifying blood. A blood flow path (a flow path between a blood inlet C1 and a blood outlet C2) through which the patient's blood flows via the blood purification membrane, and a dialysate flow path (a flow path between a dialysate inlet C3 and a dialysate outlet C4) through which the dialysate flows are formed in the dialyzer C. The hollow fiber membrane constituting the blood purification membrane has a large number of minute holes (pores) formed therein that penetrate the outer peripheral surface and the inner peripheral surface, and is configured so that impurities in the blood can permeate into the dialysate through the membrane.

[0015] When the blood pump is driven with the arterial puncture needle connected to the tip of the arterial blood circuit K1 and the venous puncture needle connected to the tip of the venous blood circuit K2 inserted into the patient, the patient's blood passes through the arterial blood circuit K1 to the dialyzer C, where it is subjected to blood purification treatment, and then passes through the venous blood circuit K2 to return to the patient's body. This allows the patient's blood to be purified by the dialyzer C while being circulated extracorporeally through the blood circuit K.

[0016] On the other hand, the main body of the device has a piping section including a dialysate inlet line L1 for introducing dialysate into the dialyzer C, and a waste fluid discharge line L2 for discharging waste fluid from the dialyzer C, and a duplex pump 1 (fluid delivery section) for delivering the dialysate and waste fluid from the piping section. The duplex pump 1 has an intake section 1a connected to the dialysate inlet line L1 and a discharge section 1b connected to the waste fluid discharge line L2, and is a pump disposed across the dialysate inlet line L1 and the waste fluid discharge line L2. When the duplex pump 1 is driven, the dialysate is introduced from the dialysate inlet line L1 to the dialyzer C, and the dialysate introduced into the dialyzer C can be discharged from the waste fluid discharge line L2 together with waste products and excess water in the blood. Note that a means other than the duplex pump 1 (for example, a so-called balancing chamber or the like) may be used.

[0017] As shown in FIG. 1, the piping section includes, in addition to the dialysis fluid inlet line L1 and the effluent discharge line L2, bypass lines L3-L5 connected to the dialysis fluid inlet line L1 and the effluent discharge line L2, a bypass line L6 that bypasses the discharge section 1b of the multiple pump 1 in the effluent discharge line L2, and an agent A concentrate inlet line L7 and an agent B concentrate inlet line L8 that connect an agent A concentrate storage tank T1 and an agent B concentrate storage tank T2, respectively, to the dialysis fluid inlet line L1.

[0018] Solenoid valves (V5-V7) are connected to the bypass lines L3-L5, respectively, and solenoid valves (V8, V9) are connected to the A agent concentrate introduction line L7 and the B agent concentrate introduction line L8, respectively. Injection pumps (8a, 8b) are connected to the A agent concentrate introduction line L7 and the B agent concentrate introduction line L8, respectively, and when the solenoid valve V8 is in an open state, the injection pump 8a is driven to introduce the A agent concentrate in the A agent concentrate storage tank T1 into the dialysis fluid introduction line L1 via the A agent concentrate introduction line L7, and when the solenoid valve V9 is in an open state, the injection pump 8b is driven to introduce the B agent concentrate in the B agent concentrate storage tank T2 into the dialysis fluid introduction line L1 via the B agent concentrate introduction line L8.

[0019] Furthermore, the dialysis fluid inlet line L1 is connected to solenoid valves (V1, V3), a heat exchanger 3, a heating section 4, a degassing pump 7, a degassing section 5, a stirring chamber (9a, 9b), and a capture section (10, 11). The heat exchanger 3 has a flow path through which the purified water (RO water) supplied to the dialysis fluid inlet line L1 flows, and a flow path through which the effluent of the effluent discharge line L2 flows, and is configured to transfer heat of the effluent to the purified water by heat exchange between these flow paths.

[0020] The heating unit 4 is composed of a heater attached to the dialysis fluid introduction line L1, and is capable of heating the purified water supplied to the dialysis fluid introduction line L1. A temperature sensor t is attached to the downstream side (right side in FIG. 1) of the heating unit 4, and is configured to be able to detect the temperature (water temperature) of the purified water heated by the heating unit 4. An orifice unit 6 is formed downstream of the temperature sensor t, and the purified water that has passed through the orifice unit 6 is introduced into the deaeration unit 5 by driving a deaeration pump 7.

[0021] The degassing unit 5 is composed of a chamber connected to the dialysis fluid introduction line L1, and a circulation line L9 (circulation flow path) is extended from the lower part of the chamber. This circulation line L9 constitutes a part of the piping section, and is connected to a predetermined position (a position between the heat exchanger 3 and the heating unit 4) on the dialysis fluid introduction line L1 upstream of the degassing unit 5, and is configured to circulate the purified water supplied to the dialysis fluid introduction line L1. In addition, a degassing line N1 extending to the waste fluid discharge line L2 is connected to the upper part of the degassing unit 5, and the air bubbles collected in the degassing unit 5 can be discharged to the outside of the piping section via the degassing line N1.

[0022] The A agent stock solution and the B agent stock solution are composed of solutions of different compositions that constitute the dialysis fluid. Specifically, the A agent stock solution (A stock solution) is composed of a mixed aqueous solution containing sodium chloride, potassium chloride, calcium chloride, magnesium chloride, sodium acetate, etc., and the B agent stock solution (B stock solution) is composed of an aqueous solution of sodium bicarbonate (NaHCO3). These A agent stock solutions and B agent stock solutions are stored in predetermined amounts in the A agent stock solution storage tank T1 and the B agent stock solution storage tank T2, respectively, and are introduced into the dialysis fluid introduction line L1 by driving the injection pumps (8a, 8b).

[0023] The stirring chambers (9a, 9b) are capable of producing a dialysis solution of a predetermined concentration by mixing and diluting the A agent stock solution and the B agent stock solution introduced into the dialysis solution introduction line L1 via the A agent stock solution introduction line L7 and the B agent stock solution introduction line L8 with purified water. That is, the purified water supplied to the dialysis solution introduction line L1 is heated by the heating unit 4 and degassed (air bubbles are removed) by the degassing unit 5 in the process of circulating through the circulation line L9, and then mixed with the A agent stock solution and the B agent stock solution to produce a dialysis solution of a predetermined concentration.

[0024] The trapping unit (10, 11) traps air bubbles contained in the dialysis fluid while passing through the dialysis fluid in the blood purification treatment process, and includes an air bubble filter (10a, 11a), a primary side portion (10b, 11b) upstream of the air bubble filter (10a, 11a) in which the trapped air bubbles are accommodated, and a secondary side portion (10c, 11c) downstream of the air bubble filter (10a, 11a) through which the permeated dialysis fluid flows. The primary side portion 10b of the trapping unit 10 is connected to the effluent discharge line L2 by a bypass line L4, and the primary side portion 11b of the trapping unit 11 is connected to the effluent discharge line L2 by a bypass line L5.

[0025] Furthermore, fluid pressure detection units (S1, S2) consisting of sensors capable of detecting fluid pressure are disposed downstream (or upstream) of the air bubble filters (10a, 11a) in the dialysis fluid introduction line L1. When the fluid pressure detection units (S1, S2) detect a predetermined change in fluid pressure during the blood purification treatment process, the solenoid valves (V6, V7) (on-off valves) are opened to discharge air bubbles in the primary side portions (10b, 11b) to the outside of the piping via the bypass lines (L4, L5) and the waste fluid discharge line L2.

[0026] On the other hand, the drainage discharge line L2 is connected to solenoid valves (V2, V4), a pressure pump P, and a degassing chamber 12, and the detouring pump 2 is connected to a bypass line L6 that bypasses the discharge section 1b of the duplex pump 1. The detouring pump 2 is for removing water (excess water) from the patient's blood flowing through the dialyzer C. That is, when the detouring pump 2 is driven, the volume of the drainage discharged from the drainage discharge line L2 becomes larger than the volume of the dialysate introduced from the dialysate introduction line L1, and the amount of water removed from the blood corresponds to the larger volume.

[0027] The degassing chamber 12 is composed of a chamber connected to the waste liquid discharge line L2, and its lower part is connected to a predetermined position of the bypass line L6 by a connection line L6a. A degassing line N2 extending to the downstream part of the waste liquid discharge line L2 is connected to the upper part of the degassing chamber 12, and the air bubbles collected in the degassing chamber 12 can be discharged to the outside of the piping part via the degassing line N2. An electromagnetic valve V10 is connected to the degassing line N2, and can be opened and closed at any time.

[0028] The control unit 13 is composed of a microcomputer disposed in the main body of the device, and executes a blood purification treatment process in which the A agent stock solution and the B agent stock solution are introduced into the piping section, mixed, and diluted to a predetermined concentration to prepare a dialysis solution, which is then sent to the dialyzer C to perform blood purification treatment. That is, in the blood purification treatment process, as shown in Fig. 2, the solenoid valves (V8, V9) are opened while the infusion pumps (8a, 8b) are operated, and the duplex pump 1 and the water removal pump 2 are driven to mix the A agent stock solution and the B agent stock solution introduced into the dialysis solution introduction line L1 with clean water to prepare a dialysis solution of a predetermined concentration, which is then sent to the dialyzer C to purify and remove water from the patient's blood for dialysis treatment.

[0029] Here, in addition to the blood purification treatment process, the control unit 13 according to this embodiment is capable of executing a bicarbonate aqueous solution production process in which a predetermined volume of bicarbonate aqueous solution is produced while discharging carbon dioxide by the heating unit 4 and the deaeration unit 5, and a degreasing and washing process in which the bicarbonate aqueous solution obtained by introducing and heating the agent B stock solution into the piping section is circulated to perform degreasing and washing to remove grease from the piping section. The bicarbonate aqueous solution production process is a process in which the agent B stock solution used in the blood purification treatment process is used to produce an alkaline agent (aqueous sodium carbonate solution) used in the degreasing and washing process, and the degreasing and washing process is a process in which the alkaline agent produced in the bicarbonate aqueous solution production process is circulated through the piping section to perform degreasing and washing.

[0030] More specifically, in the bicarbonate aqueous solution generating step, as shown in Fig. 3, the end of the dialysis fluid inlet line L1 and the end of the waste fluid discharge line L2 are connected and short-circuited by a coupler D, the solenoid valves (V4, V5, V9) are opened and the other solenoid valves are closed, and the degassing pump 7 and the injection pump 8b are driven. At this time, the duplex pump 1 and the water removal pump 2 are stopped. As a result, the B agent stock solution in the B agent stock solution storage tank T2 can be introduced into the dialysis fluid inlet line L1, and the B agent stock solution can be heated by the heating unit 4 while being circulated through the circulation line L9.

[0031] The agent B stock solution (sodium bicarbonate (NaHCO3)) is circulated through the circulation line L9 and diluted while being heated (heated to about 65°C or higher) in the heating section 4, whereby it is decomposed into sodium carbonate (Na2CO3), water (H2O), and carbon dioxide (CO2). This allows an aqueous sodium carbonate solution (aqueous bicarbonate solution) to be produced from the agent B stock solution as an alkaline agent used in the degreasing and cleaning process. The carbon dioxide produced when the agent B stock solution is heated in the heating section 4 is collected in the degassing section 5 and is discharged to the outside of the piping section via the degassing line N1 and the waste liquid discharge line L2.

[0032] In the bicarbonate aqueous solution production process, the heating section 4 heats the agent B stock solution introduced into the piping section, and the degassing section 5 can discharge to the outside of the piping section the carbon dioxide generated when the agent B stock solution is heated by the heating section 4. That is, in the process of circulating the agent B stock solution through the circulation line L9, the agent B stock solution can be heated by the heating section 4 to produce an aqueous sodium carbonate solution (aqueous bicarbonate solution), while the carbon dioxide can be discharged by the degassing section 5.

[0033] In this way, the heating unit 4 and the degassing unit 5 heat and degas the purified water for preparing a dialysis solution of a predetermined concentration by mixing the A agent stock solution and the B agent stock solution while circulating them through the circulation line L9 in the blood purification treatment step, and can heat the B agent stock solution to generate an aqueous sodium carbonate solution while discharging carbon dioxide in the bicarbonate aqueous solution generation step. Then, after the bicarbonate aqueous solution generation step of generating a predetermined volume of an aqueous sodium carbonate solution while discharging carbon dioxide is performed by the heating unit 4 and the degassing unit 5, the degreasing and washing step is performed using the aqueous sodium carbonate solution.

[0034] Furthermore, in this embodiment, the storage section has a storage section for storing a predetermined volume of aqueous sodium carbonate solution produced by heating the agent B stock solution. This storage section is made up of flow paths at predetermined locations constituting the piping section, and in this embodiment, includes a heat exchange flow path of the heat exchanger 3 which exchanges heat with the effluent discharge line L1 in the dialysis fluid inlet line L1. That is, the storage section is made up of flow paths including the circulation line L9 upstream (left side in FIG. 3 ) of the connection part with the agent B stock solution inlet line L8 in the dialysis fluid inlet line L1, the heat exchange flow path of the heat exchanger 3, and the bypass line L3, and is capable of storing the aqueous sodium carbonate solution produced in the bicarbonate aqueous solution production step.

[0035] In the degreasing and washing step, as shown in FIG. 4, the end of the dialysis fluid introduction line L1 and the end of the waste fluid discharge line L2 are connected to each other by a coupler D, the solenoid valves (V1, V2, V5, V10) are opened, the other solenoid valves are closed, and the degassing pump 7, the duplex pump 1, the water removal pump 2, and the pressurizing pump P are driven. At this time, the injection pumps (8a, 8b) are stopped. The solenoid valves (V5 to V7) are opened at any timing when the bypass lines (L3 to L5) are degreased and washed. As a result, the sodium carbonate aqueous solution stored in the storage section can be circulated and washed through the piping section to perform the degreasing and washing.

[0036] Next, the control contents by the control unit 13 according to this embodiment will be described with reference to the flowchart of FIG. First, the tip of the dialysis fluid inlet line L1 and the tip of the waste fluid discharge line L2 are connected to each other by a coupler D to short-circuit the line, and clean water is supplied from the dialysis fluid inlet line L1 to flow through each flow path constituting the piping section, thereby performing a pre-cleaning operation (S1). This allows the dialysis fluid in the piping section to be washed away.

[0037] 3, the agent B stock solution in the agent B stock solution storage tank T2 is introduced into the dialysis solution introduction line L1 (S2) to execute the bicarbonate aqueous solution production step. As a result, the agent B stock solution is circulated through the circulation line L9 and heated by the heating unit 4 to produce an aqueous sodium carbonate (Na2CO3) solution of a predetermined concentration, and carbon dioxide (CO2) is discharged from the degassing line N1 (S3).

[0038] The produced aqueous sodium carbonate solution is stored in a storage section made up of a circulation line L9 located upstream (left side in FIG. 3) of the connection between the dialysis fluid inlet line L1 and the B agent stock solution inlet line L8, the heat exchange flow path of the heat exchanger 3, and a flow path including the bypass line L3. Then, in S4, it is determined whether the injection amount of the B agent stock solution has reached or exceeded a specified value, and if it is determined to be at or above the specified value, the process proceeds to S5, where a degreasing and washing step is performed.

[0039] In the degreasing and cleaning step, as shown in Fig. 4, the aqueous sodium carbonate solution stored in the storage section is circulated through each flow path of the piping section by driving the duplex pump 1 or the like. Note that in the degreasing and cleaning step, the agent A stock solution storage tank T1 and the agent B stock solution storage tank T2 may be removed from the agent A stock solution introduction line L7 and the agent B stock solution introduction line L8, and the aqueous sodium carbonate solution may be circulated through the agent A stock solution introduction line L7 and the agent B stock solution introduction line L8 to perform degreasing and cleaning. In this way, the cleaning action of the aqueous sodium carbonate solution can remove proteins derived from the patient, and the piping section is degreasing and cleaning.

[0040] Then, when the degreasing and washing step is completed, a post-washing operation is performed by supplying clean water from the dialysis fluid introduction line L1 and circulating it through each flow path constituting the piping section (S6). This allows the sodium carbonate aqueous solution in the piping section to be washed away. As a result, the bicarbonate aqueous solution production step and the degreasing and washing step are completed, and the piping section is cleaned and disinfected, so that the blood purification treatment step can be performed.

[0041] According to this embodiment, heating Part 4 and deaeration section 5, a bicarbonate aqueous solution production process is carried out in which a predetermined volume of sodium carbonate aqueous solution is produced while discharging carbon dioxide, and then a degreasing and cleaning process is carried out using the sodium carbonate aqueous solution. Therefore, the B agent stock solution used in the blood purification treatment process can be reused as the alkaline agent used in the degreasing and cleaning process, and the degreasing and cleaning process can be carried out reliably and smoothly.

[0042] In addition, in this embodiment, the system is provided with a B agent stock solution inlet line L8 for introducing the B agent stock solution into the piping section, and the heating section 4 and the degassing section 5 are arranged upstream of the B agent stock solution inlet line L8 in the liquid sending direction (rightward in FIG. 3 ) of the aqueous sodium carbonate solution in the degreasing and cleaning process, and the storage section (the circulation line L9 upstream of the connection part of the dialysis fluid inlet line L1 with the B agent stock solution inlet line L8, the heat exchange flow path of the heat exchanger 3, and the flow path including the bypass line L3) are arranged upstream of the heating section 4 and the degassing section 5 in the liquid sending direction, and the control section 13 controls the bicarbonate aqueous solution production. In the formation process, the B agent stock solution is introduced from the B agent stock solution introduction line L8 in the opposite direction to the flow direction of the bicarbonate aqueous solution (leftward in Figure 3) and heated and degassed in the heating section 4 and degassing section 5 to generate a bicarbonate aqueous solution, and the bicarbonate aqueous solution is then further sent in the opposite direction to the flow direction to be stored in the storage section.Therefore, the introduced B agent stock solution can be immediately heated and degassed, and a predetermined volume of B agent stock solution can be continuously introduced by introducing it from the heating section 4 and degassing section 5 to the storage section in the opposite direction to the flow direction.

[0043] In addition, the piping section has a circulation line L9 (circulation flow path) that circulates the B agent stock solution introduced into the piping section, and in the process of circulating the B agent stock solution in the circulation line L9, the B agent stock solution is heated in the heating section 4 to produce an aqueous sodium carbonate solution while carbon dioxide is discharged in the degassing section 5, so that the carbon dioxide generated during the production of the aqueous sodium carbonate solution can be reliably and efficiently discharged outside the piping section.

[0044] Furthermore, the heating unit 4 and the degassing unit 5 heat and degas the purified water used to produce a dialysis solution of a predetermined concentration by mixing and circulating the A agent stock solution and the B agent stock solution through the circulation line L9 in the blood purification treatment process, so that the heating unit 4, the degassing unit 5 and the circulation line L9 used in the blood purification treatment process can be reused to heat, degas and circulate the B agent stock solution in the bicarbonate aqueous solution production process.

[0045] Furthermore, since the device has a storage section for storing a predetermined volume of aqueous bicarbonate solution produced by heating the B agent stock solution, the amount of aqueous sodium carbonate solution required in the degreasing and cleaning process can be produced in the aqueous bicarbonate solution production process. In particular, since the storage section is made up of a flow path at a predetermined location constituting the piping section, a separate new storage section is not required. Also, the storage section is a heat exchanger for exchanging heat between the dialysis fluid inlet line L1 and the effluent discharge line L2. vessel Since the heat exchange passage 3 is included, a relatively large amount of sodium carbonate aqueous solution can be stored.

[0046] 6, the storage unit in another embodiment may be composed of a storage container 15 having a heating unit 14 and a degassing line N3 as a degassing unit, and storing a predetermined volume of aqueous sodium carbonate solution generated by heating in the heating unit 14. The storage container 15 of the storage unit is connected to the dialysis fluid introduction line L1, and is connected to the B concentrate storage tank T2 via the B concentrate introduction line L8.

[0047] A heating unit 14 is disposed inside the storage container 15, and a degassing line N3 is extended from the top, allowing gas (carbon dioxide) inside the storage container 15 to be discharged to the outside. The storage container 15 contains purified water supplied to the dialysis fluid introduction line L1, and when the bicarbonate aqueous solution generating process is performed, the injection pump 8b is driven with the solenoid valve V9 in the open state, and the agent B concentrate in the agent B concentrate storage tank T2 is introduced into the storage container 15.

[0048] As a result, the agent B stock solution is heated in the heating section 14 while being diluted with the clean water in the storage container 15, and an aqueous sodium carbonate (Na2CO3) solution of a predetermined concentration is produced, while carbon dioxide (CO2) is discharged from the degassing line N3. In this way, if the storage section has the heating section 14 and the degassing line N3 as a degassing section, and is made up of a storage container that stores a predetermined volume of the aqueous sodium carbonate solution produced by heating in the heating section 14, it is possible to reliably produce the aqueous sodium carbonate solution required in the degreasing and cleaning process, and also reliably discharge carbon dioxide.

[0049] Furthermore, since the storage container 15 is connected to the dialysis fluid introduction line L1, and the heating unit 14 and the degassing line N3 as a degassing unit can mix the A agent stock solution and the B agent stock solution in the blood purification treatment process to prepare a dialysis fluid of a predetermined concentration, the storage container 15 can be used in both the blood purification treatment process and the bicarbonate aqueous solution production process. Furthermore, the storage container 15 is not limited to one connected to the dialysis fluid introduction line L1, and may be one connected to, for example, the B agent stock solution introduction line. In this case, the storage container 15 can be disposed without changing the components connected to the dialysis fluid introduction line L1 or their arrangement.

[0050] Although the present embodiment has been described above, the present invention is not limited thereto, and for example, instead of discharging the carbon dioxide generated in the bicarbonate aqueous solution production process through the degassing line N3, it may be released into the outside air through a line open to the atmosphere. Furthermore, the heating unit 4 and the degassing unit 5 may be dedicated means not used in the blood purification treatment process, in addition to using the means used in the blood purification treatment process as in the present embodiment.

[0051] In this embodiment, the B agent stock solution is introduced into the piping section, heated, and the resulting sodium carbonate aqueous solution is circulated to degrease and clean the piping section, but a bicarbonate aqueous solution different from the sodium carbonate aqueous solution may be circulated. Furthermore, although this embodiment is applied to a personal dialysis machine, it can be applied to other types of blood purification machines, such as a multi-person dialysis machine. [Industrial Applicability]

[0052] The present invention can also be applied to blood purification devices having different external shapes or with added functions, so long as they are equivalent to the spirit of the present invention. [Explanation of symbols]

[0053] 1. Duplex pump (liquid delivery section) 1a Suction part 1b Discharge section 2. Water removal pump 3 Heat exchanger 4 Heating section 5 Deaeration section 6 Orifice 7 Degassing pump 8a, 8b Infusion pump 9a, 9b Stirring chamber 10, 11 Capture unit 10a, 11a Air bubble filter 10b, 11b Primary site 10c, 11c Secondary side part 12 Degassing chamber 13 Control section 14 Heating section 15 Containment Container L1 Dialysis fluid introduction line L2 Drainage line L3~L5 bypass line L6 Detour Line L6a connection line L7 Agent A stock solution introduction line L8 B agent stock solution introduction line L9 Circulation Line N1, N2, N3 degassing lines C Dialyzer (blood purifier) C1 Blood inlet C2 blood outlet C3 Dialysate inlet C4 Dialysate outlet K blood circuit K1 Arterial blood circuit K2 Venous blood circuit T1 Agent A stock solution storage tank T2 B agent stock solution storage tank t Temperature sensor S1, S2 Liquid pressure detector P Pressure Pump

Claims

1. A blood purification device that circulates a patient's blood extracorporeally through a blood purifier and a blood circuit, and purifies the blood, a piping section having a dialysis fluid introduction line for introducing a dialysis fluid into the blood purifier and a waste fluid discharge line for discharging a waste fluid from the blood purifier; A fluid delivery section that delivers the dialysis fluid and the drainage fluid from the piping section; a control unit that executes a blood purification treatment step in which an A agent stock solution and a B agent stock solution are introduced into the piping portion, mixed, and diluted to a predetermined concentration to prepare a dialysis solution, and the dialysis solution is sent to the blood purifier to perform blood purification treatment; and a degreasing and washing step in which a bicarbonate aqueous solution is circulated through the piping portion to perform a degreasing and washing step to remove grease from the piping portion. A heating section that heats the agent B stock solution introduced into the piping section; a deaeration section that discharges carbon dioxide generated when the heating section heats the agent B stock solution to the outside of the piping section; wherein the control unit performs the degreasing and washing step using the bicarbonate aqueous solution after performing a bicarbonate aqueous solution generating step of generating a predetermined volume of bicarbonate aqueous solution while discharging carbon dioxide using the heating unit and the deaeration unit.

2. 2. The blood purification apparatus according to claim 1, further comprising a circulation flow path for circulating the agent B stock solution introduced into the piping section, and in the process of circulating the agent B stock solution through the circulation flow path, the agent B stock solution is heated in the heating section to produce an aqueous bicarbonate solution while carbon dioxide is discharged in the degassing section.

3. 3. The blood purification device according to claim 2, wherein the heating unit and the degassing unit heat and degas purified water for preparing a dialysis solution of a predetermined concentration by mixing the agent A stock solution and the agent B stock solution while circulating them through the circulation flow path in the blood purification treatment step.

4. 4. The blood purification apparatus according to claim 1, further comprising a storage section for storing a predetermined volume of an aqueous bicarbonate solution produced by heating the agent B stock solution.

5. 5. The blood purification apparatus according to claim 4, wherein the reservoir portion is formed of a flow path at a predetermined portion constituting the piping portion.

6. The blood purification apparatus according to claim 5 , wherein the reservoir portion includes a heat exchange flow path for exchanging heat between the dialysate inlet line and the waste fluid discharge line.

7. 5. The blood purification apparatus according to claim 4, wherein the storage unit is formed integrally with the heating unit and the degassing unit and comprises a container for storing a predetermined volume of the aqueous bicarbonate solution produced by the heating unit and the degassing unit.

8. The storage container is connected to the dialysis fluid introduction line, 8. The blood purification apparatus according to claim 7, wherein the heating unit and degassing unit heats and degasses purified water for preparing a dialysis solution of a predetermined concentration by mixing the agent A stock solution and the agent B stock solution in the blood purification treatment step.

9. an agent A stock solution introduction line for introducing the agent A stock solution into the dialysis fluid introduction line, and an agent B stock solution introduction line for introducing the agent B stock solution into the piping portion; The blood purification apparatus according to claim 7 , wherein the storage container is connected to the agent B stock solution introduction line.

10. a B agent stock solution introduction line for introducing the B agent stock solution into the piping portion, The heating section and the deaeration section are disposed upstream of the B agent stock solution introduction line in a liquid sending direction of the bicarbonate aqueous solution in the degreasing and cleaning step, A storage section is provided upstream of the heating section and the degassing section in the liquid sending direction, 10. The blood purification apparatus according to claim 1, wherein the control unit generates an aqueous bicarbonate solution by heating and degassing the B agent stock solution introduced from the B agent stock solution introducing line in a direction opposite to the liquid feed direction in the heating unit and degassing unit, and further sends the bicarbonate aqueous solution in the direction opposite to the liquid feed direction to store it in the storage unit.

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