Drinking composition

Abstract

To provide an excellent beverage composition which comprises biotin, a crude drug and a polyvinyl pyrrolidone and suppresses reduction in stability properties of a beverage composition and in stability properties of biotin with time.SOLUTION: It was found that reduction in stability properties of a beverage composition and content of biotin with time can be suppressed by using a specific crude drug and a specific grade of a polyvinyl pyrrolidone, that is, there is provided a beverage composition which comprises a) biotin, b) polyvinyl pyrrolidone K90c and c) at least one crude drug selected from the group consisting of ginger, Angelica acutiloba, Paeonia lactiflora, Polygonatum sibiricum, Chinese wolfberry, royal jelly, Dioscorea Rhizome, longan aril, Eucommia ulmoides, ginseng, processed Daisan, Eleutherococcus Senticosus Rhizome, Jujube and lycium bark.SELECTED DRAWING: None

Description

[Technical field]

[0001] The present invention relates to a drinkable composition containing biotin. [Background technology]

[0002] Biotin is a type of vitamin B, also known as vitamin H or coenzyme R, and is an essential component for maintaining normal skin and hair. It is also expected to be effective in fatigue recovery because it is involved in carbohydrate, amino acid, and lipid metabolism. It is known that when biotin-containing oral liquid preparations are stored in the acidic range of pH 2 to 4, precipitation and haze occur over time in the liquid preparation, resulting in poor stability of properties. As a method for preventing the formation of precipitation and haze, a method of incorporating polyvinylpyrrolidone is known (Patent Document 1). In addition, since herbal medicines have various efficacy and effects depending on the type, many drinking compositions containing herbal medicines are on the market. However, drinking compositions containing herbal medicines may cause precipitation due to the herbal medicines, and it has been reported that the precipitation can be improved by adding polyvinylpyrrolidone (Patent Document 2). [Prior art documents] [Patent documents]

[0003] [Patent Document 1] Japanese Patent Application Publication No. 7-76520 [Patent Document 2] Japanese Patent Application Publication No. 10-45627 Summary of the Invention [Problem to be solved by the invention]

[0004] In developing a drinkable composition that can be expected to improve skin and hair disorders and recover from fatigue, the inventors have investigated the combination of biotin with a specific herbal medicine, and have found that when polyvinylpyrrolidone is simultaneously added to suppress precipitation derived from the herbal medicine, the biotin content decreases over time.In addition, the inventors have investigated the combination of biotin with a specific herbal medicine, and have found that when polyvinylpyrrolidone is simultaneously added to suppress precipitation derived from the herbal medicine, the biotin content decreases during low-temperature storage.

[0005] Therefore, an object of the present invention is to provide an excellent drinking composition which contains biotin, herbal medicines, and polyvinylpyrrolidone, and which has stable properties and inhibits a decrease in the biotin content over time. [Means for solving the problem]

[0006] As a result of intensive research aimed at solving the above problems, the inventors discovered that the use of specific herbal medicines and a specific grade of polyvinylpyrrolidone can stabilize the properties of a drinking composition and suppress the decrease in biotin content, and thus completed the present invention.

[0007] That is, the present invention (1) a) Biotin b) Polyvinylpyrrolidone K90 c) a drinkable composition containing at least one herbal medicine selected from the group consisting of ginger, Angelica sinensis, peony root, rhizome, wolfberry, royal jelly, dioscorea oleracea, longan berry, eucommia ulmoides, carrot, processed daisan, schizophyllum chinense, taiso, and jiggoppi; (2) The drinkable composition according to (1), having a pH of 2.5 to 5.5. It is. Effect of the Invention

[0008] According to the present invention, it is possible to provide an excellent drinkable composition that contains a specific herbal medicine and biotin and prevents a decrease in the biotin content. The drinkable composition of the present invention also has good property stability. DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS

[0009] The content of biotin in the drinkable composition of the present invention is preferably 0.00001 to 0.0025% by mass, and more preferably 0.0005 to 0.001% by mass.

[0010] The specific grade of polyvinylpyrrolidone in the present invention is polyvinylpyrrolidone K90. Polyvinylpyrrolidone K90 means a linear polymer of 1-vinyl-2-pyrrolidone, and a compound having a Fikentscher K value (hereinafter, K value) of 77 to 103. It is a white to slightly yellow crystal that dissolves in water to form a colloidal solution. The content of polyvinylpyrrolidone K90 in the drinking composition of the present invention is preferably 0.1 to 3 mass%, more preferably 0.1 to 2 mass%.

[0011] The herbal medicines in the present invention are ginger, angelica, peony, rhizome, wolfberry, royal jelly, dioscorea gracilis, longan nut, eucommia, carrot, processed daisan, schizo, taiso, and jikopi. These are preferably blended in the form of an extract. The production of the extract is carried out by a conventional method, for example, a method of extracting from a raw material at an appropriate temperature (low temperature or heat) using an extraction solvent. The extraction solvent can be appropriately selected, but preferably water, a hydrophilic solvent, or a mixed solvent thereof is used, and in particular, ethanol is preferably used as the hydrophilic solvent. The extract of the present invention can be used as a liquid extract as it is, or it can be used as a diluted product with water, a concentrated liquid extract, or a dried liquid extract. That is, the extract of the present invention includes any of a dried extract, a soft extract, a liquid extract, and a tincture. The extract can also be purchased as a commercially available product.

[0012] The pH of the drinking composition according to the present invention is not particularly limited, and is, for example, 2.0 to 7.0. From the viewpoint of flavor, a low pH is preferable, and more preferably 2.5 to 5.5. A commonly used pH adjuster can be used to adjust the pH of the drinking composition according to the present invention. Specific examples of the pH adjuster include organic acids such as citric acid, malic acid, tartaric acid, succinic acid, lactic acid, acetic acid, maleic acid, gluconic acid, aspartic acid, adipic acid, glutamic acid, and fumaric acid, and salts thereof, inorganic acids such as hydrochloric acid, and inorganic bases such as sodium hydroxide.

[0013] Other ingredients such as other vitamins, minerals, amino acids and their salts, other herbal medicines and herbal extracts can be appropriately blended into the drinkable composition of the present invention as long as the effects of the present invention are not impaired.

[0014] Furthermore, if necessary, additives such as acidulants, antioxidants, colorants, fragrances, flavorings, preservatives, seasonings, bittering agents, strengthening agents, solubilizers, and emulsifiers can be appropriately blended within a range that does not impair the effects of the present invention.

[0015] The drinking composition of the present invention can be prepared by a conventional method, and the method is not particularly limited. Usually, each component is dissolved in an appropriate amount of purified water, the pH is adjusted, the remaining purified water is added to adjust the volume, and the composition is filtered and sterilized as necessary, and then filled into a container.

[0016] The drinkable composition of the present invention can be applied to various preparations such as medicines and quasi-drugs, including syrups and drinks, as well as various beverages such as health drinks and soft drinks. EXAMPLES

[0017] (Comparative Examples 1 to 3) According to Table 1, the above components were dissolved in purified water, filtered and sterilized, adjusted to pH 3, and filled into a 50 mL glass bottle with a cap to produce a drinking composition.

[0018] [Table 1]

[0019] (Test Example 1) The stability of biotin was examined when the drinking compositions of Comparative Examples 1 to 3 in Table 1 were stored at 65° C. for 9 days. The residual biotin rate was determined by measuring the amount of remaining biotin by HPLC (liquid chromatography). The results are shown in Table 2.

[0020] [Table 2]

[0021] As is clear from Table 2, when polyvinylpyrrolidone was added to biotin, the stability of biotin decreased (Comparative Examples 1 to 3).

[0022] (Example 1, Comparative Examples 4 to 5) According to the composition shown in Table 3, the above components were dissolved in purified water, filtered and sterilized, adjusted to pH 3, and filled into a 50 mL glass bottle with a cap to prepare a drinking composition. The ginger extract used was ginger extract manufactured by Nippon Funa Yakuhin Co., Ltd.

[0023] [Table 3]

[0024] (Test Example 2) The stability of biotin was examined when the drinkable compositions of Example 1 and Comparative Examples 4 to 5 in Table 3 were stored for 7 days at 65° C. The residual biotin rate was determined in the same manner as in Test Example 1. The results are shown in Table 4.

[0025] [Table 4]

[0026] As is clear from Table 4, the decrease in stability of biotin in the drinkable composition containing biotin, ginger extract, and polyvinylpyrrolidone K90 was suppressed. When comparing the stability of biotin when polyvinylpyrrolidone K30 and K90 were added, the stability of biotin was clearly improved when polyvinylpyrrolidone K90 was added.

[0027] (Test Example 3) The properties of the preparations were evaluated after storing the drinking compositions of Example 1 and Comparative Examples 4 to 5 in Table 3 at 65°C for 7 days. The evaluation was performed by visual observation by two people, with Comparative Example 5 used as a control. As a result, while precipitation or haze was formed in Comparative Example 5, the formation of precipitation or haze was suppressed in Example 1 and Comparative Example 4 by the incorporation of polyvinylpyrrolidone, and improvement in properties was observed.

[0028] (Examples 2 to 9, Comparative Examples 6 to 13) Drinking compositions were produced by dissolving the compositions in Examples 2 to 9 and Comparative Examples 6 to 13 shown in Tables 5 to 6 in purified water, filtering and sterilizing the solutions, adjusting the pH to 3, and filling them into 50 mL glass bottles with caps. The stability of biotin in these solutions was examined when they were stored at 65°C for 7 days. The residual biotin rate was determined in the same manner as in Test Example 1. The results are shown in Tables 5 and 6.

[0029] The angelica extract was angelica flow extract manufactured by Alps Pharmaceuticals, the angelica extract was angelica flow extract S manufactured by Matsuura Pharmaceuticals, the peony extract was peony extract manufactured by Alps Pharmaceuticals, the wolfberry extract was wolfberry flow extract manufactured by Nippon Powder Pharmaceuticals, the royal jelly extract was royal jelly extract manufactured by Nippon Beekeeping, the dianthus extract was dianthus flow extract manufactured by Ogi Pharmaceutical, the longan extract was longan extract manufactured by Nippon Powder Pharmaceuticals, and the eucommia extract was eucommia leaf extract manufactured by Nippon Powder Pharmaceuticals.

[0030] [Table 5]

[0031] [Table 6]

[0032] As is clear from Tables 5 and 6, when comparing the stability of biotin when polyvinylpyrrolidone K30 and K90 are added to a beverage composition containing biotin and Angelica sinensis, Peony root, Coptis root, Lycium fructus, royal jelly, Dioscorea Root, Longan Fruit or Eucommia ulmoides, the stability of biotin was clearly improved when polyvinylpyrrolidone K90 was added.

[0033] (Examples 10 to 14, Comparative Examples 14 to 18 ) Examples 10 to 14 and Comparative Examples 14 to 18 The composition was dissolved in purified water, filtered and sterilized, adjusted to pH 3, and filled into a 50 mL glass bottle with a cap to produce a drinking composition. The stability of biotin in these solutions was examined when they were stored at 5°C for 7 days. The residual biotin rate was determined in the same manner as in Test Example 1. The results are shown in Tables 7 and 8.

[0034] The carrot extract was Carrot Extract P manufactured by Alps Pharmaceuticals, the processed daisan was Oxoamide powder manufactured by Riken Chemical Industry Co., Ltd., the Shigoka extract was Shigoka Flow Extract manufactured by Alps Pharmaceuticals, the Taiso extract was Taiso Soft Extract manufactured by Ogi Pharmaceutical, and the Jicoppi extract was Jicoppi Extract manufactured by Matsuura Pharmaceutical Co., Ltd.

[0035] [Table 7]

[0036] [Table 8]

[0037] As is clear from Tables 7 and 8, when comparing the low-temperature stability of biotin when polyvinylpyrrolidone K30 and K90 are added to a beverage composition containing biotin and carrots, processed daisan, shigoka, taiso or jikoppi, the stability of biotin was clearly improved when polyvinylpyrrolidone K90 was added. [Industrial Applicability]

[0038] According to the present invention, a drinkable composition having improved stability and properties of biotin can be obtained, and the drinkable composition can be used for medicines, foods, health drinks, foods for specified health uses, etc.

Claims

1. a) Biotin b) Polyvinylpyrrolidone K90, and c) at least one herbal medicine selected from the group consisting of ginger, angelica, peony, rhizome, wolfberry, royal jelly, dioscorea, longan berry, eucommia, carrot, processed daisan, schizophyllum, taiso, and jiggoppi A drinkable composition comprising:

2. The drinkable composition according to claim 1, having a pH of 2.5 to 5.5.

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