Pesticide granule composition for application to rice seedling boxes with reduced chemical damage

Abstract

[Problem] To provide a granular agricultural chemical composition for a rice seedling raising box with which harmful effects are reduced. [Solution] A granular agricultural chemical composition for a rice seedling raising box, the composition being characterized by containing an agricultural chemical active ingredient, an alkyl naphthalene sulfonate derivative, an alphanized starch, and a smectite mineral.

Description

[Technical field]

[0001] The present invention relates to a granular pesticide composition for application to rice seedling boxes, which reduces chemical damage, and a method for producing the same.

[0002] When using pesticides, it is preferable to reduce the amount or frequency of use of pesticides from the viewpoint of labor saving and reducing environmental load. In response to such demands, in transplanted rice cultivation, the pesticide used in the main field is applied to the seedling box, and its effect is exerted in the main field after transplantation. However, when seedlings are treated with normal granular pesticides, there are cases where the eluted or released pesticide active ingredients or other ingredients cause phytotoxicity such as delayed or poor growth of the seedlings. For this reason, there is a demand for the development of a seedling box treatment agent that does not cause or reduces phytotoxicity to young seedlings during the seedling raising period.

[0003] To date, pesticide formulations have been reported that aim to reduce phytotoxicity caused by contact between seedlings and pesticide active ingredients in seedling boxes by suppressing the elution of pesticide active ingredients (Patent Documents 1, 2, and 3). As a method other than elution control, pesticide formulations that aim to reduce phytotoxicity to seedlings by adding specific substances have also been reported (Patent Document 4). [Prior art documents] [Patent documents]

[0004] [Patent Document 1] JP 2012-111752 A [Patent Document 2] Special Publication No. 2012-508713 [Patent Document 3] JP 2012-17271 A [Patent Document 4] JP 2009-221108 A Summary of the Invention [Problem to be solved by the invention]

[0005] An object of the present invention is to provide an agrochemical formulation composition having an excellent phytotoxicity reducing effect against agrochemical active ingredients that are highly at risk of causing poor growth of rice seedlings.

[0006] The present inventors have discovered that a pesticide granule composition for application to rice seedling boxes, which contains a pesticide active ingredient, an alkylnaphthalenesulfonic acid derivative, pregelatinized starch, and a smectite mineral, has an excellent effect of reducing damage caused by pesticides, and have thus completed the present invention.

[0007] The present invention provides the following solutions.

[0008] [1] A pesticide granule composition for application to rice seedling boxes, comprising an pesticide active ingredient, an alkylnaphthalenesulfonic acid derivative, pregelatinized starch, and a smectite mineral.

[0009] [2] The pesticide granule composition according to [1], wherein the content of the pesticide active ingredient is 1 to 30 weight percent.

[0010] [3] The pesticide granule composition according to [1] or [2], wherein the content of the alkylnaphthalenesulfonic acid derivative is 0.1 to 2.0 weight percent.

[0011] [4] The pesticide granule composition according to any one of [1] to [3], wherein the content of pregelatinized starch is 0.1 to 10 weight percent.

[0012] [5] The pesticide granule composition according to any one of [1] to [4], wherein the smectite mineral is bentonite.

[0013] [6] The pesticide granule composition according to any one of [1] to [5], wherein the content of the smectite mineral is 1 to 50 weight percent. Effect of the Invention

[0014] When the granular pesticide composition of the present invention is applied to rice seedling boxes, it can reduce phytotoxicity caused by ingredients containing pesticidal active ingredients. DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS

[0015] The present invention provides an agrochemical granule composition for application to rice seedling boxes, which comprises an agrochemically active ingredient, an alkylnaphthalenesulfonic acid derivative, a smectite mineral, and pregelatinized starch.

[0016] Agrochemically active ingredients in the context of the present invention means insecticides, acaricides, nematicides, fungicides, bactericides, molluscicides, microbicides, beneficial organisms, apple snail killers, herbicides, bird repellents, plant strengtheners, sterilizers, semiochemicals and / or plant growth regulators.

[0017] Insecticides / Acaricides / Nematocides The active ingredients identified herein by "common name" are known and can be found, for example, in "The Pesticide Manual", 16th ed., British Crop Protection Council 2012, or on the internet (e.g., http: / / www.alanwood.net / pesticides). The classification is based on the IRAC Mode of Action Classification Scheme applicable at the time of filing this patent application.

[0018] (1) Acetylcholinesterase (AChE) inhibitors, e.g. Carbamates, such as alanycarb, aldicarb, bendiocarb, benfuracarb, butocarboxim, butoxycarboxim, carbaryl, carbofuran, carbosulfan, ethiofencarb, fenobucarb, formetanate, furathiocarb, isoprocarb, methiocarb, methomyl, metolcarb, oxamyl, pirimicarb, propoxur, thiodicarb, thiofanox, triazamate, trimethacarb, XMC, and xylylcarb; or Organophosphates, e.g., acephate, azamethiphos, azinphos-ethyl, azinphos-methyl, cadusafos, chlorethoxyphos, chlorfenvinphos, chlormephos, chlorpyrifos-methyl, coumaphos, cyanophos, demeton-S-methyl, diazinon, dichlorvos / DDVP, dicrotophos, dimethoate, dimethylvinphos, disulfoton, EPN, ethion, ethoprophos, famfur, fenamiphos, fenitrothion, fenthion, fosthiazate, heptenophos, imicyaphos, isofenphos, O-(methoxyaminothiophos) folyl) isopropyl salicylate, isoxathion, malathion, mecarbam, methamidophos, methidathion, mevinphos, monocrotophos, naled, omethoate, oxydemeton-methyl, parathion-methyl, phenthoate, phorate, phosalone, phosmet, phosphamidon, phoxim, pirimiphos-methyl, profenofos, propetamphos, prothiofos, pyraclofos, pyridaphenthion, quinalphos, sulfotep, tebupirimphos, temephos, terbufos, tetrachlorvinphos, thiometon, triazophos, trichlorfon, and vamidothion.

[0019] (2) GABA-regulated chloride channel blockers, e.g. Cyclodiene-organochlorines, such as chlordane and endosulfan; or 13. Phenylpyrazoles (Fiproles) such as Ethiprole and Fipronil.

[0020] (3) Sodium channel modulators, e.g. Pyrethroids, such as acrinathrin, allethrin, d-cis-trans allethrin, d-trans allethrin, bifenthrin, bioallethrin, bioallethrin S-cyclopentenyl isomer, bioresmethrin, cycloprothrin, cyfluthrin, beta-cyfluthrin, cyhalothrin, lambda-cyhalothrin, gamma-cyhalothrin, cypermethrin, alpha-cypermethrin, beta-cypermethrin, theta-cypermethrin, zeta-cypermethrin, cyphenothrin [(1R)-trans isomer], deltamethrin, empenthrin [(EZ)-(1R) isomer], esfenvalerate, etofenprox, fenpropathrin, fenvalerate, flucythrinate, flumethrin, tau-fluvalinate, halfenprox, imiprothrin, kadethrin, momfluorothrin, permethrin, fenothrin [(1R)-trans isomer], prallethrin, pyrethrins (pyrethrum), resmethrin, silafluofen, tefluthrin, tetramethrin, tetramethrin [(1R) isomer], tralomethrin, and transfluthrin; or DDT; or methoxychlor.

[0021] (4) Nicotinic acetylcholine receptor (nAChR) competitive modulators, e.g. Neonicotinoids, such as acetamiprid, clothianidin, dinotefuran, imidacloprid, nitenpyram, thiacloprid, and thiamethoxam; or Nicotine; or Sulfoxaflor or flupyradifurone.

[0022] (5) Nicotinic acetylcholine receptor (nAChR) allosteric modulators, e.g. 13. Spinosyns such as Spinetoram and Spinosad.

[0023] (6) GluCl-regulated chloride channel (GluCl) allosteric modulators, e.g. 13. Avermectins / Milbemcyins such as Abamectin, Emamectin Benzoate, Lepimectin, and Milbemectin.

[0024] (7) Juvenile hormone mimetics, e.g. Juvenile hormone analogs, such as hydroprene, kinoprene, and methoprene; or Fenoxycarb; or pyriproxyfen.

[0025] (8) Various unspecified (multi-site) inhibitors, e.g. Alkyl halides, such as methyl bromide and other alkyl halides; or Chloropicrin; or sulfuryl fluoride; or borax; or tartar emetic; or 13. Methyl isocyanate generators such as diazomet and metham.

[0026] (9) Chordotonal organ modulators, e.g. Pymetrozine; or flonicamide.

[0027] (10) Mite growth inhibitors, e.g. Clofentezine, hexythiazox, and diflovidazine; or Etoxazole.

[0028] (11) Microbial disruptors of the insect midgut membrane, e.g. Bacillus thuringiensis subspecies israelensis, Bacillus sphaericus, Bacillus thuringiensis subspecies aizawai, Bacillus thuringiensis subspecies kurstaki, Bacillus thuringiensis subspecies tenebrionis, and Bt plant proteins: Cry1Ab, Cry1Ac, Cry1Fa, Cry1A.105, Cry2Ab, Vip3A, mCry3A, Cry3Ab, Cry3Bb, Cry34Ab1 / 35Ab1.

[0029] (12) Inhibitors of mitochondrial ATP synthase, e.g., ATP disruptors, e.g., Diafenthiuron; or Organotin compounds, such as azocyclotin, cyhexatin, and fenbutatin oxide; or Propargite; or tetradifon.

[0030] (13) Uncouplers of oxidative phosphorylation by disrupting the proton gradient, e.g. Chlorfenapyr, DNOC, and sulfluramide.

[0031] (14) Nicotinic acetylcholine receptor channel blockers, for example: Bensultap, Cartap Hydrochloride, Thiocyclam, and Thiosultap-Sodium.

[0032] (15) Chitin biosynthesis inhibitors (type 0), e.g. Bistrifluron, chlorfluazuron, diflubenzuron, flucycloxuron, flufenoxuron, hexaflumuron, lufenuron, novaluron, noviflumuron, teflubenzuron, and triflumuron.

[0033] (16) Chitin biosynthesis inhibitors (type 1), e.g. Buprofezin.

[0034] (17) Molting disruptors (especially in Diptera), e.g. Cyromazine.

[0035] (18) Ecdysone receptor agonists, for example Chromafenozide, halofenozide, methoxyfenozide, and tebufenozide.

[0036] (19) Octopamine receptor agonists, for example: Amitraz.

[0037] (20) Mitochondrial complex III electron transport inhibitors, for example: hydramethylnon; or acequinocyl; or fluacrypyrim.

[0038] (21) Mitochondrial complex I electron transport inhibitors, e.g. METI acaricides, such as fenazaquin, fenpyroximate, pyrimidifen, pyridaben, tebufenpyrad, and tolfenpyrad; or Rotenone (Derris).

[0039] (22) Voltage-dependent sodium channel blockers, e.g. Indoxacarb; or metaflumizone.

[0040] (23) Acetyl-CoA carboxylase inhibitors, e.g. Tetronic acid derivatives and tetramic acid derivatives, such as spirodiclofen, spiromesifen, and spirotetramat.

[0041] (24) Mitochondrial complex IV electron transport inhibitors, e.g. Phosphine-based, such as aluminum phosphide, calcium phosphide, phosphine, and zinc phosphide; or Cyanide, calcium cyanide, potassium cyanide, and sodium cyanide.

[0042] (25) Mitochondrial complex II electron transport inhibitors, e.g. β-Ketonitrile derivatives such as cyenopyrafen and cyflumetofen, and carboxanilides such as piflubumid.

[0043] (28) Ryanodine receptor modulators, e.g. Diamides such as chlorantraniliprole, cyantranilprole, flubendiamide, tetraniliprole, and tetrachlorantraniliprole.

[0044] Further active ingredients, such as afidopiropen, afoxolaner, azadirachtin, impurfluxam, benclotiaz, benzoximate, bifenazate, broflanilide, bromopropylate, quinomethionate, chloroprallethrin, cryolite, cyclaniprole, cycloxaprid, cyhalodiamide, dichloromezotiaz, dicofol, epsilon metofluthrin, epsilon momfluthrin, momfluthrin, flometoquin, fluazaindolizine, fluensulfone, flufenerim, flufenoxystrobin, flufiprole, fluhexafon, fluopyram, fluralaner, fluxamethamide, fufenozide, guadipyr, heptafluthrin, imidaclothiz, iprodione, kappa-bifenthrin, kappa-tefluthrin, lotilaner, meperfluthrin, paichongding, pyridalyl, pyrifluquinazone, pyriminostrobin, spirobudiclofen, tetramethylfluthrin, thioxazaphen, thiofluoximate, triflumezopyrim, and iodomethane; and Bacillus firmus) (I-1582, BioNeem, Votivo), and the following compounds: 1-{2-fluoro-4-methyl-5-[(2,2,2-trifluoroethyl)sulfinyl]phenyl}-3-(trifluoromethyl)-1H-1,2,4-triazol-5-amine (known from WO 2006 / 043635) (CAS 885026-50-6), {1'-[(2E)-3-(4-chlorophenyl)prop-2-en-1-yl]-5-fluorospiro[indole-3,4'-piperidine]-1(2H)-yl}(2-chloropyridin-4-yl)methanone (known from WO2003 / 106457) (CAS 637360-23-7), 2-chloro-N-[2-{1-[(2E)-3-(4-chlorophenyl)prop-2-en-1-yl]piperidin-4-yl}-4-(trifluoromethyl)phenyl]isonicotinamide (known from WO2006 / 003494) (CAS 872999-66-1), 3-(4-chloro-2,6-dimethylphenyl)-4-hydroxy-8-methoxy-1,8-diazaspiro[4.5]dec-3-en-2-one (known from WO2010052161) (CAS 1225292-17-0), 3-(4-chloro-2,6-dimethylphenyl)-8-methoxy-2-oxo-1,8-diazaspiro[4.5]dec-3-en-4-yl ethyl carbonate (known from EP2647626) (CAS-1440516-42-6), 4-(but-2-yn-1-yloxy)-6-(3,5-dimethylpiperidin-1-yl)-5-fluoropyrimidine (known from WO2004 / 099160) (CAS 792914-58-0), PF1364 (known from JP2010 / 018586) (CAS Reg. No. 1204776-60-2), N-[(2E)-1-[(6-chloropyridin-3-yl)methyl]pyridin-2(1H)-ylidene]-2,2,2-trifluoroacetamide (known from WO2012 / 029672) (CAS 1363400-41-2), (3E)-3-[1-[(6-chloro-3-pyridyl)methyl]-2-pyridylidene]-1,1,1-trifluoropropan-2-one (known from WO2013 / 144213) (CAS 1461743-15-6), N-[3-(benzylcarbamoyl)-4-chlorophenyl]-1-methyl-3-(pentafluoroethyl)-4-(trifluoromethyl)-1H-pyrazole-5-carboxamide (known from WO2010 / 051926) (CAS 1226889-14-0), 5-bromo-4-chloro-N-[4-chloro-2-methyl-6-(methylcarbamoyl)phenyl]-2-(3-chloro-2-pyridyl)pyrazole-3-carboxamide (known from CN103232431) (CAS 1449220-44-3), 4-[5-(3,5-dichlorophenyl)-4,5-dihydro-5-(trifluoromethyl)-3-isoxazolyl]-2-methyl-N-(cis-1-oxido-3-thietanyl)benzamide, 4-[5-(3,5-dichlorophenyl)-4,5-dihydro-5-(trifluoromethyl)-3-isoxazolyl]-2-methyl-N-(trans-1-oxido-3-thietanyl)benzamide and 4-[(5S)-5-(3,5-dichlorophenyl)-4,5-dihydro-5-(trifluoromethyl)-3-isoxazolyl]-2-methyl-N-(cis-1-oxido-3-thietanyl)benzamide (known from WO2013 / 050317A1) (CAS 1332628-83-7), N-[3-chloro-1-(3-pyridinyl)-1H-pyrazol-4-yl]-N-ethyl-3-[(3,3,3-trifluoropropyl)sulfinyl]propanamide, (+)-N-[3-chloro-1-(3-pyridinyl)-1H-pyrazol-4-yl]-N-ethyl-3-[(3,3,3-trifluoropropyl)sulfinyl]propanamide and (-)-N-[3-chloro-1-(3-pyridinyl)-1H-pyrazol-4-yl]-N-ethyl-3-[(3,3,3-trifluoropropyl)sulfinyl]propanamide (known from WO2013 / 162715A2, WO2013 / 162716A2, US2014 / 0213448A1) (CAS 1477923-37-7), 5-[[(2E)-3-chloro-2-propen-1-yl]amino]-1-[2,6-dichloro-4-(trifluoromethyl)phenyl]-4-[(trifluoromethyl)sulfinyl]-1H-pyrazole-3-carbonitrile (known from CN101337937A) (CAS 1105672-77-2), 3-bromo-N-[4-chloro-2-methyl-6-[(methylamino)thioxomethyl]phenyl]-1-(3-chloro-2-pyridinyl)-1H-pyrazole-5-carboxamide, (Liudaibenjiaxuanan, known from CN103109816A) (CAS 1232543-85-9); N-[4-chloro-2-[[(1,1-dimethylethyl)amino]carbonyl]-6-methylphenyl]-1-(3-chloro-2-pyridinyl)-3-(fluoromethoxy)-1H-pyrazole-5-carboxamide (known from WO2012 / 034403A1) (CAS 1268277-22-0), N-[2-(5-amino-1,3,4-thiadiazol-2-yl)-4-chloro-6-methylphenyl]-3-bromo-1-(3-chloro-2-pyridinyl)-1H-pyrazole-5-carboxamide (known from WO2011 / 085575A1) (CAS 1233882-22-8), 4-[3-[2,6-dichloro-4-[(3,3-dichloro-2-propen-1-yl)oxy]phenoxy]propoxy]-2-methoxy-6-(trifluoromethyl)pyrimidine (CN101337940A) (known from CAS 1108184-52-6); (2E)- and 2(Z)-2-[2-(4-cyanophenyl)-1-[3-(trifluoromethyl)phenyl]ethylidene]-N-[4-(difluoromethoxy)phenyl]hydrazinecarboxamide (known from CN101715774A) (CAS 1232543-85-9; cyclopropanecarboxylic acid 3-(2,2-dichloroethenyl)-2,2-dimethyl-4-(1H-benzimidazol-2-yl)phenyl ester (known from CN103524422A) (CAS 1542271-46-4); (4aS)-7-chloro-2,5-dihydro-2-[[(methoxycarbonyl)[4-[(trifluoromethyl)thio]phenyl]amino]carbonyl]indeno[1,2-e][1,3,4]oxadiazine-4a(3H)-carboxylic acid methyl ester (known from CN102391261A) (CAS 1370358-69-2;6-deoxy-3-O-ethyl-2,4-di-O-methyl-1-[N-[4-[1-[4-(1,1,2,2,2-pentafluoroethoxy)phenyl]-1H-1,2,4-Triazol-3-yl]phenyl]carbamate]-α-L-mannopyranose (known from US2014 / 0275503A1) (CAS 1181213-14-8); 8-(2-cyclopropylmethoxy-4-trifluoromethylphenoxy)-3-(6-trifluoromethylpyridazin-3-yl)-3-azabicyclo[3.2.1]octane (CAS 1253850-56-4), (8-anti)-8-(2-cyclopropylmethoxy-4-trifluoromethylphenoxy)-3-(6-trifluoromethylpyridazin-3-yl)-3-azabicyclo[3.2.1]octane (CAS 933798-27-7), (8-syn)-8-(2-cyclopropylmethoxy-4-trifluoromethylphenoxy)-3-(6-trifluoromethylpyridazin-3-yl)-3-azabicyclo[3.2.1]octane (known from WO2007040280A1, WO2007040282A1) (CAS 934001-66-8), and N-[3-chloro-1-(3-pyridinyl)-1H-pyrazol-4-yl]-N-ethyl-3-[(3,3,3-trifluoropropyl)thio]propanamide (known from WO2015 / 058021A1, WO2015 / 058028A1) (CAS 1477919-27-9).

[0045] Fungicides The active ingredients identified herein by "common name" are known and are described, for example, in the "Pesticide Manual" (16th Ed., British Crop Protection Council) or can be found on the internet (e.g., http: / / www.alanwood.net / pesticides).

[0046] All components described in classes (1) to (15) may optionally form salts with suitable bases or acids, if possible based on their functional groups. All fungicide mixture components described in classes (1) to (15) may optionally include tautomeric forms.

[0047] (1) Inhibitors of ergosterol biosynthesis, for example: (1.001) cyproconazole, (1.002) difenoconazole, (1.003) epoxiconazole, (1.004) fenhexamid, (1.005) fenpropidin, (1.006) fenpropimorph, (1.007) fenpyrazamine, (1.008) fluquinconazole, (1.009) flutriafol, (1.010) imazalil, (1.011) imazalil sulfate, (1.012) ipconazole, (1.013) metconazole, (1.014). Myclobutanil, (1.015) Paclobutrazol, (1.016) Prochloraz, (1.017) Propiconazole, (1.018) Prothioconazole, (1.019) Pyrisoxazole, (1.020) Spiroxamine, (1.021) Tebuconazole, (1.022) Tetraconazole, (1.023) Triadimenol, (1.024) Tridemorph, (1.025) Triticonazole, (1.026) (1R,2S,5S)-5-(4-chlorobenzyl)-2-(chloromethyl)-2-methyl-1-(1H -1,2,4-triazol-1-ylmethyl)cyclopentanol, (1.027) (1S,2R,5R)-5-(4-chlorobenzyl)-2-(chloromethyl)-2-methyl-1-(1H-1,2,4-triazol-1-ylmethyl)cyclopentanol, (1.028) (2R)-2-(1-chlorocyclopropyl)-4-[(1R)-2,2-dichlorocyclopropyl]-1-(1H-1,2,4-triazol-1-yl)butan-2-ol (1.029) (2R)-2-(1-chlorocyclopropyl)- 4-[(1S)-2,2-dichlorocyclopropyl]-1-(1H-1,2,4-triazol-1-yl)butan-2-ol, (1.030) (2R)-2-[4-(4-chlorophenoxy)-2-(trifluoromethyl)phenyl]-1-(1H-1,2,4-triazol-1-yl)propan-2-ol, (1.031) (2S)-2-(1-chlorocyclopropyl)-4-[(1R)-2,2-dichlorocyclopropyl]-1-(1H-1,2,4-triazol-1-yl)butan-2-ol, (1.032) (2S)-2-(1-chlorocyclopropyl)-4-[(1S)-2,2-dichlorocyclopropyl]-1-(1H-1,2,4-triazol-1-yl)butan-2-ol, (1.033) (2S)-2-[4-(4-chlorophenoxy)-2-(trifluoromethyl)phenyl]-1-(1H-1,2,4-triazol-1-yl)propan-2-ol, (1.034) (R)-[3-(4-chloro-2-fluorophenyl)-5-(2,4-difluorophenyl)-1,2-oxazol-4-yl](pyridin-3-yl) (1.035) (S)-[3-(4-chloro-2-fluorophenyl)-5-(2,4-difluorophenyl)-1,2-oxazol-4-yl](pyridin-3-yl)methanol, (1.036) [3-(4-chloro-2-fluorophenyl)-5-(2,4-difluorophenyl)-1,2-oxazol-4-yl](pyridin-3-yl)methanol, (1.037) 1-({(2R,4S)-2-[2-chloro-4-(4-chlorophenoxy)phenyl]-4-methyl-1,3-dioxolan-2-yl}methyl )-1H-1,2,4-triazole, (1.038) 1-({(2S,4S)-2-[2-chloro-4-(4-chlorophenoxy)phenyl]-4-methyl-1,3-dioxolan-2-yl}methyl)-1H-1,2,4-triazole, (1.039) 1-{[3-(2-chlorophenyl)-2-(2,4-difluorophenyl)oxiran-2-yl]methyl}-1H-1,2,4-triazol-5-yl thiocyanate, (1.040) 1-{[rel(2R,3R)-3-(2-chlorophenyl)-2-(2,4-difluorophenyl)oxiran-2-yl]methyl}-1H-1,2,4-triazol-5-yl thiocyanate (1.041) 1-{[rel(2R,3S)-3-(2-chlorophenyl)-2-(2,4-difluorophenyl)oxiran-2-yl]methyl}-1H-1,2,4-triazol-5-yl thiocyanate, (1.042) 2-[(2R,4R,5R)-1-(2,4-dichlorophenyl)-5-hydroxy-2,6,6-trimethylheptan-4-yl]-2,4-dihydro-3H-1,2,4-triazole-3-thione, (1.043) 2-[(2R,4R,5S)-1-(2,4-dichlorophenyl)-5-hydroxy-2,6,6-trimethylheptan-4-yl]-2,4-dihydro-3H-1,2,4-triazole-3-thione, (1.044) 2-[(2R,4S,5R)-1-(2,4-dichlorophenyl)-5-hydroxy-2,6,6-trimethylheptan-4-yl]-2,4-dihydro-3H-1,2,4-triazole-3-thione, (1.045) 2-[(2R,4S,5S)-1-(2,4-dichlorophenyl)-5-hydroxy-2,6,6-trimethylheptan-4-yl]-2,4-dihydro-3H-1,2,4-triazole-3-thione, (1.046) 2-[(2S,4R,5R)-1-(2,4-dichlorophenyl)-5-hydroxy-2,6,6-trimethylheptan-4-yl]-2,4-dihydro-3H-1,2,4-triazole-3-thione, (1.047) 2-[(2S,4R,5S)-1-(2,4-dichlorophenyl)-5-hydroxy-2,6,6-trimethylheptan-4-yl]-2,4-dihydro-3H-1,2,4-triazole-3-thione, (1.048) 2-[(2S,4S,5R)-1-(2,4-dichlorophenyl)-5-hydroxy-2,6,6-trimethylheptan-4-yl]-2,4-dihydro-3H-1,2,4-triazole-3-thione, (1.049) 2-[(2S,4S,5S)-1-(2,4-dichlorophenyl)-5-hydroxy-2,6,6-trimethylheptan-4-yl]-2,4-dihydro-3H-1,2,4-triazole-3-thione, (1.050) 2-[1-(2,4-dichlorophenyl)-5-hydroxy-2,6,6-trimethylheptan-4-yl]-2,4-dihydro-3H-1,2,4-triazole-3-thione, (1.051) 2-[2-chloro-4-(2,4-dichlorophenoxy)phenyl]-1-(1H-1,2,4-triazol-1-yl)propan-2-ol, (1.052) 2-[2-chloro-4-(4-chlorophenoxy)phenyl]-1-(1H-1,2,4-triazol-1-yl)butan-2-ol, (1.053) 2-[4-(4-chlorophenoxy)-2-(trifluoromethyl)phenyl]-1-(1H-1,2,4-triazol-1-yl)butan-2-ol, (1.054) 2-[4-(4-chlorophenoxy)-2-(trifluoromethyl)phenyl]-1-(1H-1,2,4-triazol-1-yl)pentan-2-ol, (1.055) 2-[4-(4-chlorophenoxy)-2-(trifluoromethyl)phenyl]-1-(1H-1,2,4-triazol-1-yl)propan-2-ol, (1.056) 2-{ [3-(2-chlorophenyl)-2-(2,4-difluorophenyl)oxiran-2-yl]methyl}-2,4-dihydro-3H-1,2,4-triazole-3-thione, (1.057) 2-{[rel(2R,3R)-3-(2-chlorophenyl)-2-(2,4-difluorophenyl)oxiran-2-yl]methyl}-2,4-dihydro-3H-1,2,4-triazole-3-thione, (1.058) 2-{[rel(2R,3S)-3-(2-chlorophenyl)-2-(2,4-difluorophenyl)oxiran-2-yl] methyl}-2,4-dihydro-3H-1,2,4-triazole-3-thione, (1.059) 5-(4-chlorobenzyl)-2-(chloromethyl)-2-methyl-1-(1H-1,2,4-triazol-1-ylmethyl)cyclopentanol, (1.060) 5-(arylsulfanyl)-1-{[3-(2-chlorophenyl)-2-(2,4-difluorophenyl)oxiran-2-yl]methyl}-1H-1,2,4-triazole, (1.061) 5-(arylsulfanyl)-1-{[rel(2R,3R)-3-(2-chlorophenyl)oxiran-2-yl]methyl}-1H-1,2,4-triazole phenyl)-2-(2,4-difluorophenyl)oxiran-2-yl]methyl}-1H-1,2,4-triazole, (1.062) 5-(arylsulfanyl)-1-{[rel(2R,3S)-3-(2-chlorophenyl)-2-(2,4-difluorophenyl)oxiran-2-yl]methyl}-1H-1,2,4-triazole, (1.063) N'-(2,5-dimethyl-4-{[3-(1,1,2,2-tetrafluoroethoxy)phenyl]sulfanyl}phenyl)-N-ethyl-N-methylimidoformamide, (1.064) N'-(2,5-dimethyl-4-{[3-(2,2,2-trifluoroethoxy)phenyl]sulfanyl}phenyl)-N-ethyl-N-methylimidoformamide, (1.065) N'-(2,5-dimethyl-4-{[3-(2,2,3,3-tetrafluoropropoxy)phenyl]sulfanyl}phenyl)-N-ethyl-N-methylimidoformamide, (1.066) N'-(2,5-dimethyl-4-{[3-(pentafluoroethoxy)phenyl]sulfanyl}phenyl)-N-ethyl-N-methylimidoformamide N-ethyl-N-methylimidoformamide, (1.067) N'-(2,5-dimethyl-4-{3-[(1,1,2,2-tetrafluoroethyl)sulfanyl]phenoxy}phenyl)-N-ethyl-N-methylimidoformamide, (1.068) N'-(2,5-dimethyl-4-{3-[(2,2,2-trifluoroethyl)sulfanyl]phenoxy}phenyl)-N-ethyl-N-methylimidoformamide, (1.069) N'-(2,5-dimethyl-4-{3-[(2,2,3,3-tetrafluoropropyl)sulfanyl]phenoxy}phenyl)-N-ethyl-N-methylimidoformamide (1.070) N'-(2,5-dimethyl-4-{3-[(pentafluoroethyl)sulfanyl]phenoxy}phenyl)-N-ethyl-N-methylimidoformamide, (1.071) N'-(2,5-dimethyl-4-phenoxyphenyl)-N-ethyl-N-methylimidoformamide, (1.072) N'-(4-{[3-(difluoromethoxy)phenyl]sulfanyl}-2,5-dimethylphenyl)-N-ethyl-N-methylimidoformamide, (1. 073) N'-(4-{3-[(difluoromethyl)sulfanyl]phenoxy}-2,5-dimethylphenyl)-N-ethyl-N-methylimidoformamide, (1.074) N'-[5-bromo-6-(2,3-dihydro-1H-inden-2-yloxy)-2-methylpyridin-3-yl]-N-ethyl-N-methylimidoformamide, (1.075) N'-{4-[(4,5-dichloro-1,3-thiazol-2-yl)oxy]-2,5-dimethylphenyl}-N-ethyl-N-methylimidoformamide, (1.076) N'-{5-bromo-6-[(1R)-1-(3,5-difluorophenyl)ethoxy]-2-methylpyridin-3-yl}-N-ethyl-N-methylimidoformamide, (1.077) N'-{5-bromo-6-[(1S)-1-(3,5-difluorophenyl)ethoxy]-2-methylpyridin-3-yl}-N-ethyl-N-methylimidoformamide, (1.078) N'- {5-bromo-6-[(cis-4-isopropylcyclohexyl)oxy]-2-methylpyridin-3-yl}-N-ethyl-N-methylimidoformamide, (1.079) N'-{5-bromo-6-[(trans-4-isopropylcyclohexyl)oxy]-2-methylpyridin-3-yl}-N-ethyl-N-methylimidoformamide, (1.080) N'-{5-bromo-6-[1. -(3,5-difluorophenyl)ethoxy]-2-methylpyridin-3-yl}-N-ethyl-N-methylimidoformamide.

[0048] (2) Inhibitors of the respiratory chain at complex I or complex II, such as (2.001) benzovindiflupyr, (2.002) bixafen, (2.003) boscalid, (2.004) carboxin, (2.005) fluopyram, (2.006) flutolanil, (2.007) fluxapyroxad, (2.008) furametpyr, (2.009) isofetamide, (2.010) isopyrazam (anti-epimer enantiomer 1R,4S,9S), (2.011) isopyrazam (anti-epimer enantiomer 1S,4R,9R), (2.012) isopyrazam (anti-epimer racemate 1RS,4SR,9SR), (2.013) Isopyrazam (mixture of syn-epimeric racemate (1RS,4SR,9RS) and anti-epimeric racemate (1RS,4SR,9SR)), (2.014) Isopyrazam (syn-epimeric enantiomers 1R,4S,9R), (2.015) Isopyrazam (syn-epimeric enantiomers 1S,4R,9S), (2.016) Isopyrazam (syn-epimeric racemate 1RS,4SR,9RS), (2.017) Penflufen, (2.018) Penthiopyrad, (2.019) Pydiflumetofen, (2.020) Pyraziflumide, (2.021) Sedaxane, (2.022) 1,3-Dimethyl-N-(1,1,3-trimethyl-2,3-dihydro-1H-inden-4-yl)-1H-pyrazole-4-carboxamide, (2.023) 1,3-Dimethyl-N-[(3R)-1,1,3-trimethyl-2,3-dihydro-1H-inden-4-yl]-1H-pyrazole (2.024) 1,3-dimethyl-N-[(3S)-1,1,3-trimethyl-2,3-dihydro-1H-inden-4-yl]-1H-pyrazole-4-carboxamide, (2.025) 1-methyl-3-(trifluoromethyl)-N-[2'-(trifluoromethyl)biphenyl-2-yl]-1H-pyrazole-4-carboxamide, (2.026) 2-fluoro-6-(trifluoromethyl)-N-(1,1,3-trimethyl-2,3-dihydro-1H-inden-4-yl)benzamide, (2.027) 3-(difluoromethyl)-1-methyl-N-(1,1,3-trimethyl-2,3-dihydro-1H-inden-4-yl)-1H-pyrazole-4-carboxamide, (2.028) 3-(difluoromethyl)-1-methyl-N-[(3R)-1,1,3-trimethyl-2,3-dihydro-1H-inden-4-yl]-1H-pyrazole-4-carboxamide, (2.029) 3-(difluoromethyl)-1-methyl-N-[(3S)-1,1,3-trimethyl-2,3-dihydro-1H-inden-4-yl]-1H -pyrazole-4-carboxamide, (2.030) 3-(difluoromethyl)-N-(7-fluoro-1,1,3-trimethyl-2,3-dihydro-1H-inden-4-yl)-1-methyl-1H-pyrazole-4-carboxamide, (2.031) 3-(difluoromethyl)-N-[(3R)-7-fluoro-1,1,3-trimethyl-2,3-dihydro-1H-inden-4-yl]-1-methyl-1H-pyrazole-4-carboxamide, (2.032) 3-(difluoromethyl)-N-[(3S)-7-fluoro-1,1 ,3-trimethyl-2,3-dihydro-1H-inden-4-yl]-1-methyl-1H-pyrazole-4-carboxamide, (2.033) 5,8-difluoro-N-[2-(2-fluoro-4-{[4-(trifluoromethyl)pyridin-2-yl]oxy}phenyl)ethyl]quinazolin-4-amine, (2.034) N-(2-cyclopentyl-5-fluorobenzyl)-N-cyclopropyl-3-(difluoromethyl)-5-fluoro-1-methyl-1H-pyrazole-4-carboxamide, (2.035) N-(2-t (2.036) N-(2-tert-butylbenzyl)-N-cyclopropyl-3-(difluoromethyl)-5-fluoro-1-methyl-1H-pyrazole-4-carboxamide, (2.037) N-(5-chloro-2-ethylbenzyl)-N-cyclopropyl-3-(difluoromethyl)-5-fluoro-1-methyl-1H-pyrazole-4-carboxamide, (2.038) N-(5-chloro-2-ethylbenzyl)-N-cyclopropyl-3-(difluoromethyl)-5-fluoro-1-methyl-1H-pyrazole-4-carboxamide, (2.039) N-(5-chloro-2-ethylbenzyl)-N-cyclopropyl-3-(difluoromethyl)-5-fluoro-1-methyl-1H-pyrazole-4-carboxamide, (2.040) N-(5-chloro-2-ethylbenzyl)-N-cyclopropyl-3-(difluoromethyl)-5-fluoro-1-methyl-1H-pyrazole-4-carboxamide, (2.041) N-(5-chloro-2-ethylbenzyl)-N-cyclopropyl-3-(difluoromethyl)-5-fluoro-1-methyl-1H-pyrazole-4-carboxamide, (2.042) N-(5-chloro-2-ethylbenzyl)-N-cyclopropyl-3-(difluoromethyl)-5-fluoro-1-methyl-1H-pyrazole-4-carboxamide, (2.043) N-(5-chloro-2-ethylbenzyl)-N-cyclopropyl-3-(difluoromethyl)-5-fluoro-1-methyl-1H-pyrazole-4-carboxamide, (2.044) N-(5-chloro-2-ethylbenzyl)-N-cyclopropyl-3-(difluoromethyl)-5-fluoro-1-methyl-1H-pyrazole-4-carboxamide, (2.045) N038) N-(5-chloro-2-isopropylbenzyl)-N-cyclopropyl-3-(difluoromethyl)-5-fluoro-1-methyl-1H-pyrazole-4-carboxamide, (2.039) N-[(1R,4S)-9-(dichloromethylene)-1,2,3,4-tetrahydro-1,4-methanonaphthalene-5-yl]-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide, (2.040) N-[(1S,4R)-9-(dichloromethylene)-1,2,3,4-tetrahydro-1,4-methanonaphthalene-5-yl] N-[1-(2,4-dichlorophenyl)-1-methoxypropan-2-yl]-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide, (2.041) N-[1-(2,4-dichlorophenyl)-1-methoxypropan-2-yl]-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide, (2.042) N-[2-chloro-6-(trifluoromethyl)benzyl]-N-cyclopropyl-3-(difluoromethyl)-5-fluoro-1-methyl-1H-pyrazole-4-carboxamide, (2.043) N-[3-chloro-2-fluoro-6-(trifluoromethyl)benzyl]- ) benzyl]-N-cyclopropyl-3-(difluoromethyl)-5-fluoro-1-methyl-1H-pyrazole-4-carboxamide, (2.044) N-[5-chloro-2-(trifluoromethyl) benzyl]-N-cyclopropyl-3-(difluoromethyl)-5-fluoro-1-methyl-1H-pyrazole-4-carboxamide, (2.045) N-cyclopropyl-3-(difluoromethyl)-5-fluoro-1-methyl-N-[5-methyl-2-(trifluoromethyl) benzyl]-1H-pyrazole-4-carboxamide, (2.046 ) N-cyclopropyl-3-(difluoromethyl)-5-fluoro-N-(2-fluoro-6-isopropylbenzyl)-1-methyl-1H-pyrazole-4-carboxamide, (2.047) N-cyclopropyl-3-(difluoromethyl)-5-fluoro-N-(2-isopropyl-5-methylbenzyl)-1-methyl-1H-pyrazole-4-carboxamide, (2.048) N-cyclopropyl-3-(difluoromethyl)-5-fluoro-N-(2-isopropylbenzyl)-1-methyl-1H-pyrazole-4-carbothioamide, (2.049) N-cyclopropyl-3-(difluoromethyl)-5-fluoro-N-(2-isopropylbenzyl)-1-methyl-1H-pyrazole-4-carboxamide, (2.050) N-cyclopropyl-3-(difluoromethyl)-5-fluoro-N-(5-fluoro-2-isopropylbenzyl)-1-methyl-1H-pyrazole-4-carboxamide, (2.051) N-cyclopropyl-3-(difluoromethyl)-N-(2-ethyl-4,5-dimethylbenzyl)-5-fluoro-1-methyl-1H-pyrazole-4-carboxamide, (2.052) N-cyclopropyl-3-(difluoromethyl)-N-(2-ethyl-5-fluorobenzyl)-5-fluoro-1-methyl-1H-pyrazole-4-carboxamide, (2 .053) N-cyclopropyl-3-(difluoromethyl)-N-(2-ethyl-5-methylbenzyl)-5-fluoro-1-methyl-1H-pyrazole-4-carboxamide, (2.054) N-cyclopropyl-N-(2-cyclopropyl-5-fluorobenzyl)-3-(difluoromethyl)-5-fluoro-1-methyl-1H-pyrazole-4-carboxamide, (2.055) N-cyclopropyl-N-(2-cyclopropyl-5-methylbenzyl)-3-(difluoromethyl)-5-fluoro-1-methyl-1H-pyrazole-4-carboxamide, (2.056) N-cyclopropyl-N-(2-cyclopropylbenzyl)-3-(difluoromethyl)-5-fluoro-1-methyl-1H-pyrazole-4-carboxamide.

[0049] (3) Inhibitors of the respiratory chain at complex III, such as (3.001) amethoctrazine, (3.002) amisulbrom, (3.003) azoxystrobin, (3.004) coumethoxystrobin, (3.005) coumoxystrobin, (3.006) cyazofamid, (3.007) dimoxystrobin, (3.008) enoxastrobin, (3.009) famoxadone, (3.010) fenamidone, (3. 011) Flufenoxystrobin, (3.012) Fluoxastrobin, (3.013) Kresoxim-methyl, (3.014) Metominostrobin, (3.015) Orysastrobin, (3.016) Picoxystrobin, (3.017) Pyraclostrobin, (3.018) Pyrametstrobin, (3.019) Pyraoxystrobin, (3.020) Trifloxystrobin, (3.021) (2E)-2-{ 2-[({[(1E)-1-(3-{[(E)-1-fluoro-2-phenylvinyl]oxy}phenyl)ethylidene]amino}oxy)methyl]phenyl}-2-(methoxyimino)-N-methylacetamide, (3.022) (2E,3Z)-5-{[1-(4-chlorophenyl)-1H-pyrazol-3-yl]oxy}-2-(methoxyimino)-N,3-dimethylpent-3-enamide, (3.023) (2R)-2-{2-[(2,5-dimethyl phenoxy)methyl]phenyl}-2-methoxy-N-methylacetamide, (3.024) (2S)-2-{2-[(2,5-dimethylphenoxy)methyl]phenyl}-2-methoxy-N-methylacetamide, (3.025) (3S,6S,7R,8R)-8-benzyl-3-[({3-[(isobutyryloxy)methoxy]-4-methoxypyridin-2-yl}carbonyl)amino]-6-methyl-4,9-dioxo-1,5-dioxonan-7-yl 2-methylpropanoate, (3.026) 2-{2-[(2,5-dimethylphenoxy)methyl]phenyl}-2-methoxy-N-methylacetamide, (3.027) N-(3-ethyl-3,5,5-trimethylcyclohexyl)-3-formamido-2-hydroxybenzamide, (3.028) (2E,3Z)-5-{[1-(4-chloro-2-fluorophenyl)-1H-pyrazol-3-yl]oxy}-2-(methoxyimino)-N,3-dimethylpent-3-enamide.

[0050] (4) Mitosis and cell division inhibitors, for example, (4.001) carbendazim, (4.002) diethofencarb, (4.003) ethaboxam, (4.004) fluopicolide, (4.005) pencycuron, (4.006) thiabendazole, (4.007) thiophanate-methyl, (4.008) zoxamide, (4.009) 3-chloro-4-(2,6-difluorophenyl)-6-methyl-5-phenylpyridazine, (4.010) 3-chloro-5-(4-chlorophenyl)-4-(2,6-difluorophenyl)- )-6-methylpyridazine, (4.011) 3-chloro-5-(6-chloropyridin-3-yl)-6-methyl-4-(2,4,6-trifluorophenyl)pyridazine, (4.012) 4-(2-bromo-4-fluorophenyl)-N-(2,6-difluorophenyl)-1,3-dimethyl-1H-pyrazol-5-amine, (4.013) 4-(2-bromo-4-fluorophenyl)-N-(2-bromo-6-fluorophenyl)-1,3-dimethyl-1H-pyrazol-5-amine, (4.014) 4-(2-bromo -4-fluorophenyl)-N-(2-bromophenyl)-1,3-dimethyl-1H-pyrazol-5-amine, (4.015) 4-(2-bromo-4-fluorophenyl)-N-(2-chloro-6-fluorophenyl)-1,3-dimethyl-1H-pyrazol-5-amine, (4.016) 4-(2-bromo-4-fluorophenyl)-N-(2-chlorophenyl)-1,3-dimethyl-1H-pyrazol-5-amine, (4.017) 4-(2-bromo-4-fluorophenyl)-N-(2-fluorophenyl)-1 ,3-dimethyl-1H-pyrazol-5-amine, (4.018) 4-(2-chloro-4-fluorophenyl)-N-(2,6-difluorophenyl)-1,3-dimethyl-1H-pyrazol-5-amine, (4.019) 4-(2-chloro-4-fluorophenyl)-N-(2-chloro-6-fluorophenyl)-1,3-dimethyl-1H-pyrazol-5-amine, (4.020) 4-(2-chloro-4-fluorophenyl)-N-(2-chlorophenyl)-1,3-dimethyl-1H-pyrazol-5-amine, (4.021) 4-(2-chloro-4-fluorophenyl)-N-(2-fluorophenyl)-1,3-dimethyl-1H-pyrazol-5-amine, (4.022) 4-(4-chlorophenyl)-5-(2,6-difluorophenyl)-3,6-dimethylpyridazine, (4.023) N-(2-bromo-6-fluorophenyl)-4-(2-chloro-4-fluorophenyl)-1,3-dimethyl-1H-pyrazol-5-amine, (4.024) N-(2-bromophenyl)-4-(2-chloro-4-fluorophenyl)-1,3-dimethyl-1H-pyrazol-5-amine, (4.025) N-(4-chloro-2,6-difluorophenyl)-4-(2-chloro-4-fluorophenyl)-1,3-dimethyl-1H-pyrazol-5-amine.

[0051] (5) Compounds which may be active at multiple sites, e.g. (5.001) Bordeaux mixture, (5.002) captafol, (5.003) captan, (5.004) chlorothalonil, (5.005) copper hydroxide, (5.006) copper naphthenate, (5.007) copper oxide, (5.008) copper chloride dibasic, (5.009) copper(2+) sulfate, (5.010) dithianone, (5.011) dodine, (5.012) folpet, (5.013) mancozeb, (5.014) maneb, (5.015) metiram, (5.016) zinc metiram, (5.017) copper oxine oxine), (5.018) propineb, (5.019) sulphur and sulphur agents, for example, calcium polysulphide, (5.020) thiuram, (5.021) zineb, (5.022) ziram.

[0052] (6) Compounds capable of inducing host defenses, such as (6.001) acibenzolar-S-methyl, (6.002) isotianil, (6.003) probenazole, (6.004) thiadinil.

[0053] (7) Inhibitors of amino acid and / or protein biosynthesis, for example (7.001) cyprodinil, (7.002) kasugamycin, (7.003) kasugamycin hydrochloride hydrate, (7.004) oxytetracycline, (7.005) pyrimethanil, (7.006) 3-(5-fluoro-3,3,4,4-tetramethyl-3,4-dihydroisoquinolin-1-yl)quinoline.

[0054] (8) ATP production inhibitors, for example, (8.001) silthiofam.

[0055] (9) Cell wall synthesis inhibitors, for example: (9.001) benthiavalicarb, (9.002) dimethomorph, (9.003) flumorph, (9.004) iprovalicarb, (9.005) mandipropamide, (9.006) pyrimorph, (9.007) valifenalate, (9.008) (2E)-3-(4-tert-butylphenyl)-3-(2-chloropyridin-4-yl)-1-(morpholin-4-yl)prop-2-en-1-one, (9.009) (2Z)-3-(4-tert-butylphenyl)-3-(2-chloropyridin-4-yl)-1-(morpholin-4-yl)prop-2-en-1-one.

[0056] (10) Inhibitors of lipid and membrane synthesis, for example, (10.001) propamocarb, (10.002) propamocarb hydrochloride, (10.003) tolclofos-methyl.

[0057] (11) Melanin biosynthesis inhibitors, for example, (11.001) tricyclazole, (11.002) 2,2,2-trifluoroethyl{3-methyl-1-[(4-methylbenzoyl)amino]butan-2-yl}carbamate.

[0058] (12) Nucleic acid synthesis inhibitors, for example, (12.001) benalaxyl, (12.002) benalaxyl-M (chiralaxyl), (12.003) metalaxyl, (12.004) metalaxyl-M (mefenoxam).

[0059] (13) Signal transduction inhibitors, for example: (13.001) fludioxonil, (13.002) iprodione, (13.003) procymidone, (13.004) proquinazide, (13.005) quinoxyfen, (13.006) vinclozolin.

[0060] (14) Compounds which can act as uncouplers, for example, (14.001) fluazinam, (14.002) meptyldinocap.

[0061] (15) Further compounds, for example (15.001) abscisic acid, (15.002) benthazole, (15.003) bethoxazin, (15.004) capsimycin, (15.005) carvone, (15.006) quinomethionate, (15.007) kufuraneb, (15.008) cyflufenamid, (15.009) cymoxanil, (15.010) cyprosulfamide, (15.011) fluthianil, (15.012) fosetyl-aluminium, (15.013) fosetyl-calcium (15.014) fosetyl sodium, (15.015) methyl isothiocyanate, (15.016) metrafenone, (15.017) mildiomycin, (15.018) natamycin, (15.019) nickel dimethyldithiocarbamate, (15.020) nitrothal-isopropyl, (15.021) oxamocarb, (15.022) oxathiapiproline, (15.023) oxyfenthiin, (15.024) pentachlorophenol 15.025) Phosphonic acids and their salts, (15.026) Propamocarb-fosetylate, (15.027) Pyriophenone (chlazafenone), (15.028) Tebufloquine, (15.029) Tecloftalam, (15.030) Tornifanide, (15.031) 1-(4-{4-[(5R)-5-(2,6-difluorophenyl)-4,5-dihydro-1,2-oxazol-3-yl]-1,3-thiazole -2-yl}piperidin-1-yl)-2-[5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]ethanone, (15.032) 1-(4-{4-[(5S)-5-(2,6-difluorophenyl)-4,5-dihydro-1,2-oxazol-3-yl]-1,3-thiazol-2-yl}piperidin-1-yl)-2-[5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]ethanone, (15.033) 2-(6-benzylpyridin-2-yl)quinazoline, (15.034) 2,6-Dimethyl-1H,5H-[1,4]dithiino[2,3-c:5,6-c']dipyrrole-1,3,5,7(2H,6H)-tetrone, (15.035) 2-[3,5-bis(difluoromethyl)-1H-pyrazol-1-yl]-1-[4-(4-{5-[2-(prop-2-yn-1-yloxy)phenyl]-4,5-dihydro-1,2-oxazole -3-yl}-1,3-thiazol-2-yl)piperidin-1-yl]ethanone, (15.036) 2-[3,5-bis(difluoromethyl)-1H-pyrazol-1-yl]-1-[4-(4-{5-[2-chloro-6-(prop-2-yn-1-yloxy)phenyl]-4,5-dihydro-1,2-oxazol-3-yl}-1,3-thiazol-2-yl)piperidin-1-yl]ethanone, 1,3-thiazol-2-yl)piperidin-1-yl]ethanone, (15.037) 2-[3,5-bis(difluoromethyl)-1H-pyrazol-1-yl]-1-[4-(4-{5-[2-fluoro-6-(prop-2-yn-1-yloxy)phenyl]-4,5-dihydro-1,2-oxazol-3-yl}-1,3-thiazol-2-yl)piperidin-1-yl]ethanone, (15.038) 2- [6-(3-fluoro-4-methoxyphenyl)-5-methylpyridin-2-yl]quinazoline, (15.039) 2-{(5R)-3-[2-(1-{[3,5-bis(difluoromethyl)-1H-pyrazol-1-yl]acetyl}piperidin-4-yl)-1,3-thiazol-4-yl]-4,5-dihydro-1,2-oxazol-5-yl}-3-chlorophenyl methanesulfonate, (15.040) 2-{(5S)-3-[2-(1-{[3,5-bis(difluoromethyl)-1H-pyrazol-1-yl]acetyl}piperidin-4-yl)-1,3-thiazol-4-yl]-4,5-dihydro-1,2-oxazol-5-yl}-3-chlorophenyl methanesulfonate, (15.041) 2-{2-[(7,8-difluoro-2-methylquinolin-3-yl)oxy]-6-fluorophenyl}propan-2-ol, (15.042) 2-{2-fluoro-6-[(8-fluoro-2-methylquinolin-3-yl)oxy]phenyl}propan-2-ol, (15.043) 2-{3-[2-(1-{[3,5-bis(difluoromethyl)-1H-pyrazol-1-yl]acetyl}piperidin-4-yl)-1,3-thiazol-4-yl]-4,5-dihydro-1,2-oxazol-5-yl}-3-chlorophenyl methanesulfonate, (15.044) 2-{3-[2-(1-{[3,5-bis(difluoromethyl)-1H-pyrazol-1-yl]acetyl}piperidin-4-yl)-1,3-thiazol-4-yl]-4,5-dihydro-1,2-oxazol-5-yl}phenyl Methanesulfonate, (15.045) 2-Phenylphenol and its salts, (15.046) 3-(4,4,5-trifluoro-3,3-dimethyl-3,4-dihydroisoquinolin-1-yl)quinoline, (15.047) 3-(4,4-difluoro-3,3-dimethyl-3,4-dihydroisoquinolin-1-yl)quinoline, (15.048) 4-amino-5-fluoro Fluoropyrimidin-2-ol (tautomeric form: 4-amino-5-fluoropyrimidin-2(1H)-one), (15.049) 4-oxo-4-[(2-phenylethyl)amino]butyric acid, (15.050) 5-amino-1,3,4-thiadiazole-2-thiol, (15.051) 5-chloro-N'-phenyl-N'-(prop-2-yn-1-yl)thiophene 2-Sulfonohydrazide, (15.052) 5-Fluoro-2-[(4-fluorobenzyl)oxy]pyrimidin-4-amine, (15.053) 5-Fluoro-2-[(4-methylbenzyl)oxy]pyrimidin-4-amine, (15.054) 9-Fluoro-2,2-dimethyl-5-(quinolin-3-yl)-2,3-dihydro-1,4-benzoxazepine, (15.055) But-3-yn-1-yl{6-[({[(Z)-(1-methyl -1H-tetrazol-5-yl)(phenyl)methylene]amino}oxy)methyl]pyridin-2-yl}carbamate, (15.056) (2Z)-3-amino-2-cyano-3-phenylacrylic acid ethyl, (15.057) phenazine-1-carboxylic acid, (15.058) 3,4,5-trihydroxybenzoic acid propyl, (15.059) quinolin-8-ol, (15.060) quinolin-8-ol sulfate (2:1), (15.061) tert-Butyl {6-[({[(1-methyl-1H-tetrazol-5-yl)(phenyl)methylene]amino}oxy)methyl]pyridin-2-yl}carbamate. .

[0062] Microbial agents, beneficial organisms, include, inter alia, bacteria, fungi, yeasts, plant extracts and products formed by microorganisms (eg, proteins and secondary metabolites).

[0063] Bacteria include, for example, spore-forming bacteria, root-colonizing bacteria and bacteria that act as biological insecticides, fungicides or nematicides.

[0064] Examples of such bacteria are: Bacillus amyloliquefaciens strain FZB42 (DSM 231179), or Bacillus cereus, in particular the B. cereus strain CNCM I-1562, or Bacillus firmus strain I-1582 (accession number CNCM I-1582), or Bacillus pumilus, in particular the strain GB34 (accession number ATCC 700814) and the strain QST2808 (accession number NRRL B-30087), or Bacillus subtilis, in particular the strain GB03 (accession number ATCC 700814) SD-1397), or Bacillus subtilis strain QST713 (accession number NRRL B-21661), or Bacillus subtilis strain OST 30002 (accession number NRRL B-50421), Bacillus thuringiensis, in particular B. thuringiensis subspecies israelensis (antigen type H-14) strain AM65-52 (accession number ATCC 1276), or B. thuringiensis subsp. aizawai, in particular strain ABTS-1857 (SD-1372), or Bacillus thuringiensis B. thuringiensis subsp. kurstaki strain HD-1, or B. thuringiensis subsp. tenebrionis strain NB 176 (SD-5428), Pasteuria penetrans, Pasteuria spp.) (Rotylenchulus reniformis nematode)-PR3 (accession number ATCC SD-5834), Streptomyces microflavus strain AQ6121 (= QRD 31.013, NRRL B-50550), and Streptomyces galbus strain AQ 6047 (accession number NRRL 30232).

[0065] Examples of fungi and yeasts are: Beauveria bassiana, in particular strain ATCC 74040, Coniothyrium minitans, in particular strain CON / M / 91-8 (deposit number DSM-9660), Lecanicillium spp., in particular strain HRO LEC 12, Lecanicillium lecanii (formerly known as Verticillium lecanii), in particular strain KV01, Metarhizium anisopliae, in particular strain F52 (DSM3884 / ATCC 90448), Metschnikowia fructicola, in particular strain NRRL Y-30752, Paecilomyces fumosoroseus (new: Isaria fumosorosea), in particular strain IFPC 200613 or strain Apopka 97 (deposit number ATCC 20874), Paecilomyces lilacinus, in particular Paecilomyces lilacinus strain 251 (AGAL 89 / 030550), Talaromyces flavus, in particular strain V117b, Trichoderma atroviride, in particular strain SC1 (deposit number CBS 122089), Trichoderma harzianum, in particular Trichoderma harzianum rifai T39 (deposit number CNCM I-952).

[0066] Examples of viruses are as follows: Adoxophyes orana granulosis virus (GV), codling moth (Cydia pomonella) granulosis virus (GV), Helicoverpa armigera nuclear polyhedrosis virus (NPV), Spodoptera exigua mNPV, Spodoptera frugiperda mNPV, and African cotton leafworm (Spodoptera littoralis) NPV.

[0067] Also included are bacteria and fungi that are added as "inoculants" to plants or plant parts or plant organs and that promote plant growth and plant health by their specific properties. Examples include: Agrobacterium spp., Azorhizobium caulinodans, Azospirillum spp., Azotobacter spp., Bradyrhizobium spp., Burkholderia spp., in particular Burkholderia cepacia (formerly known as Pseudomonas cepacia), Gigaspora spp. or Gigaspora monosporum, Glomus spp., Laccaria spp. spp., Lactobacillus buchneri, Paraglomus spp., Pisolithus tinctorus, Pseudomonas spp., Rhizobium spp., in particular Rhizobium trifolii, Rhizopogon spp., Scleroderma spp., Suillus spp., Streptomyces spp.

[0068] Examples of plant extracts and products formed by microorganisms, which include proteins and secondary metabolites, are: Garlic (Allium sativum), Wormwood (Artemisia absinthium), Azadirachtin, Biokeeper WP, Cassia nigricans, Celastrus angulatus, Chenopodium anthelminticum, Chitin, Armour-Zen, Dryopteris filix-mas, Horsetail (Equisetum arvense), Fortune Aza, Fungastop, Heads Up (Chenopodium quinoa saponin extract), Pyrethrum / pyrethrins, Quassia amara, Quercus, Quillaja, Regalia, ("Requiem TM Insecticide", Rotenone, Ryania / Ryanodine, Symphytum officinale, Tanacetum vulgare, Thymol, Triact 70, TriCon, Tropaeulum majus, Urtica dioica, Veratrin, Viscum album, Brassicaceae extracts, especially rapeseed powder or mustard powder.

[0069] The smectite mineral according to the present invention preferably includes montmorillonite, beidellite, nontronite, saponite, hectorite, sauconite and stephensite. Bentonite containing montmorillonite as a main component is also included in the smectite mineral according to the present invention. Bentonite is preferable as the smectite mineral according to the present invention.

[0070] The alkylnaphthalenesulfonic acid derivative according to the present invention is preferably a sodium salt of a naphthalenesulfonic acid-formaldehyde condensate or a sodium salt of an alkylnaphthalenesulfonic acid-formaldehyde condensate, with the sodium salt of an alkylnaphthalenesulfonic acid-formaldehyde condensate being preferred.

[0071] The content of the alkylnaphthalenesulfonic acid derivative in the pesticide granule composition of the present invention is preferably 0.1 to 2.0 weight percent, more preferably 0.15 to 0.75 weight percent, and even more preferably 0.2 to 0.6 weight percent.

[0072] The content of pregelatinized starch in the pesticide granule composition of the present invention is preferably 0.1 to 10 weight percent, more preferably 0.2 to 5 weight percent, and even more preferably 0.5 to 3 weight percent.

[0073] The content of the smectite mineral in the pesticide granule composition of the present invention is preferably 1 to 50 weight percent, more preferably 2 to 30 weight percent, and even more preferably 3 to 20 weight percent.

[0074] The pesticide granule composition of the present invention may further contain auxiliary agents such as a filler, a water-soluble binder, a surfactant, a solvent, a stabilizer, a granulation promoter, a preservative, a colorant, a pH adjuster, and a fragrance.

[0075] Examples of the extender include inorganic carriers such as glassy powders obtained by pulverizing clay, calcium carbonate, silica sand and its pulverized products, diatomaceous earth, talc, ziegelite, sericite, acid clay, activated clay, silica stone, pumice, zeolite, vermiculite, white carbon, and shirasu balloons; non-water-soluble organic carriers such as cellulose, pulp, rice hulls, wood flour, starch, and soybean flour; and water-soluble solid carriers such as urea, lactose, sucrose, salt, sodium sulfate, and citric anhydride.

[0076] Water-soluble binders include sodium carboxymethylcellulose, hydroxypropylmethylcellulose, methylcellulose, methylethylcellulose, hydroxypropylcellulose, sodium polyacrylate, gum tragacanth, polyvinylpyrrolidone, polyvinyl alcohol, dextrin, alginic acid, and sodium alginate.

[0077] The surfactants include nonionic surfactants, anionic surfactants, cationic surfactants and amphoteric surfactants.

[0078] For example, examples of nonionic surfactants include polyoxyalkylene alkyl ethers, polyoxyalkylene alkylaryl ethers, polyoxyalkylene allyl phenyl ethers, polyoxyalkylene alkyl esters, polyoxyalkylene sorbitan alkylates, polyoxyalkylene phenyl ether polymers, polyoxyalkylene alkylene aryl phenyl ethers, polyoxyalkylene alkylene glycols, and polyoxyethylene polyoxypropylene block polymers.

[0079] Examples of the anionic surfactant include lignin sulfonate, alkylaryl sulfonate, dialkyl sulfosuccinate, polyoxyalkylene alkylaryl ether sulfate salt, alkylnaphthalene sulfonate, polyoxyalkylene allyl phenyl ether sulfate salt, and lauryl sulfate.

[0080] Examples of the cationic surfactant include alkyl trimethyl ammonium salts, alkyl dimethyl benzyl ammonium salts, and alkyl pyridinium salts.

[0081] Examples of amphoteric surfactants include dialkyldiaminoethyl betaine, alkyldimethylbenzyl betaine, etc. However, the surfactants that can be used in the present invention are not limited to these examples, and there is no problem in using one or more of them in combination.

[0082] Examples of pH adjusters include citric acid, malic acid, phosphoric acid, sodium citrate, potassium citrate, magnesium oxide, sodium carbonate, sodium hydrogen carbonate, disodium hydrogen phosphate, dipotassium hydrogen phosphate, trisodium phosphate, potassium pyrophosphate, sodium pyrophosphate, or hydrates or anhydrous crystals thereof. However, the pH adjusters that can be used in the present invention are not limited to these examples, and there is no problem in using one or more of them in combination.

[0083] The pesticide granule composition of the present invention can be produced by a known method. For example, the pesticide active ingredient, smectite mineral, pregelatinized starch, alkylnaphthalenesulfonic acid derivative, and, if necessary, auxiliary agents such as a filler, a water-soluble binder, a surfactant, a solvent, a stabilizer, a pH adjuster, a granulation promoter, a preservative, a coloring agent, and a fragrance are granulated by a coating method, a kneading method, or the like to prepare a desired pesticide granule.

[0084] In the case of coated granules, the agricultural chemical active ingredient, the smectite mineral, the pregelatinized starch, and the alkylnaphthalenesulfonic acid derivative may be contained in a coating layer, or may be impregnated into a water-absorbent granule core.

[0085] When producing coated granules, for example, a mixed solution of water and a surfactant is added to and mixed with a granule core, and the raw powder prepared by adding the pesticide active ingredient, smectite mineral, pregelatinized starch, alkylnaphthalenesulfonic acid derivative, and other auxiliary agents as mentioned above and mixing and grinding is coated with the resulting mixture, and the resulting mixture is then dried and, if necessary, crushed, sieved, sized, etc. to produce the desired pesticide granules.

[0086] In the coated granules, examples of the granule core include calcium carbonate components such as limestone and marble, silica sand, pumice, clay granules, granulated inorganic material granules, and the like.

[0087] On the other hand, when producing kneaded granules, the pesticide active ingredient is mixed with the smectite mineral, pregelatinized starch, alkylnaphthalenesulfonic acid derivative, and other auxiliary agents mentioned above, water is added, and the mixture is thoroughly mixed or kneaded, granulated, and the resulting granules are dried and, if necessary, crushed, sieved, sized, etc. to produce the desired pesticide granules.

[0088] The kneading is carried out using a kneading machine, such as a universal mixer, a kneader, a Loedige mixer, or a vertical granulator.

[0089] The amount of water used during kneading is usually 5 to 20 parts by weight based on 100 parts by weight of the mixture.

[0090] When the above kneaded granules are produced, a screen having a diameter of usually 0.3 to 1.8 mm, preferably 0.8 to 1.2 mm, is used.

[0091] Examples of granulators that can be used include screw-type extrusion granulators, roll-type extrusion granulators, disc pelleter-type extrusion granulators, pellet mill-type extrusion granulators, basket-type extrusion granulators, blade-type extrusion granulators, oscillating-type extrusion granulators, gear-type extrusion granulators, and ring die-type extrusion granulators. Specifically, Multigran MG-55-2; DALTON CORPORATION can be used.

[0092] The obtained granules are dried usually at 50 to 120°C, preferably 60 to 80°C.

[0093] The pesticide granule composition of the present invention can be applied at any time from before sowing to the same time as transplanting.

[0094] In the case of application before sowing, for example, a method in which a mixture of the granular pesticide composition and bed soil is added to a seedling box and then seeds are sowed can be mentioned.

[0095] In the case of application at the time of sowing, a method in which the solid pesticide composition is sprayed after sowing the seeds and before covering them with soil can be mentioned.

[0096] Examples of application at the time of transplanting include a method in which the pesticide granule composition is sprayed onto a seedling box several days before or on the day of transplanting the seedlings into a paddy field or field, and a method in which the solid pesticide composition is sprayed with a sprayer at the same time as transplanting the seedlings with a rice transplanter or the like.

[0097] The granular agricultural chemical composition of the present invention can be applied to a nursery box by any method, for example, by mixing with the bed soil as described above or by using a sprayer.

[0098] Seedling trays that can be used in the method of the present invention include rice seedling trays, cell trays for horticultural crops (vegetables, fruit trees, flowers), and plastic containers.

[0099] The application amount of the solid pesticide composition when applied to rice seedling boxes by the method of the present invention is usually 10 to 200 g, preferably 50 to 100 g per seedling box. When applied to a plastic container such as a 448-hole seedling box for Minoru Pot System (manufactured by Minoru Sangyo Co., Ltd.), the application amount is usually 33 to 66 g per container (1 to 2 kg per 10 ares).

[0100] The agrochemical granule composition for application in rice nursery boxes of the present invention can be obtained by a granulation method commonly used in the formulation of agrochemicals. For example, the agrochemical active ingredient, alkylnaphthalenesulfonic acid derivative, pregelatinized starch, smectite mineral, and optionally surfactant, water-soluble binder, solvent, auxiliary, and extender are added, mixed and pulverized with a vertical granulator (trade name of Powrex Corporation), kneaded with water, granulated with an extrusion granulator, dried with a fluidized bed dryer, and sized to prepare. Alternatively, the powder mixture may be granulated with a rolling granulator while adding water, dried, and sized, or may be produced with a fluidized bed granulator in which a binder, an aqueous solution, or an active ingredient is sprayed and granulated while the powder mixture is fluidized.

[0101] The granular material for application to rice seedling boxes of the present invention can take the form of granules, granules, tablets, etc. There are no limitations as long as the preparation is a solid preparation other than a powder. EXAMPLES

[0102] The present invention will now be described in more detail with reference to Production Examples, Examples, Comparative Examples and Test Examples, but the present invention is not limited to these.

[0103] Among the substances used in this example, those that require particular explanation are shown below.

[0104] Isotianil is a known compound and can be prepared, for example, by the method described in WO 99 / 024413.

[0105] Penflufen is a known compound and can be produced, for example, by the method described in WO 2003 / 010149.

[0106] Tetraniliprole is a known compound and can be produced, for example, by the method described in WO 2011 / 157664.

[0107] Examples of alkylnaphthalenesulfonic acid derivatives include Morwet D425 (manufactured by Akzo Nobel), TERSPERSE 2020 (manufactured by Huntsman), and Agrosurf WG-2300 (manufactured by Takemoto Oil Co., Ltd.).

[0108] Examples of pregelatinized starches include Amycol HF, Amycol C, Amycol KF, Amycol HG-N, Amycol BJ-2, ​​Amycol W, Starch MH-A, Amycol A, Amycol FW (manufactured by Nippon Starch Chemical Co., Ltd.), Nisshoku Alster, Nisshoku Alster H, Nisshoku Waxy α (manufactured by Nippon Shokuhin Kako Co., Ltd.), Corn αY, Corn αS-1, Industrial Tapioca α, Industrial Tapioca α TP-2, Wheat Starch αWA-105 (manufactured by Sanwa Starch Co., Ltd.), Amilox No. 1, and Amilox No. 1A (manufactured by Nippon Corn Starch Co., Ltd.).

[0109] The smectite mineral is preferably montmorillonite, and examples of such bentonite include Bentonite Fuji, Bentonite Hotaka, Bentonite Akagi, Bentonite Myogi, Super Clay (manufactured by Hojun Co., Ltd.), Kunigel V1, Kunigel V2, Kunigel VA, Kunibond (manufactured by Kunimine Kogyo Co., Ltd.), and Kansai Bentonite (manufactured by Kanesan Kogyo Co., Ltd.).

[0110] The solid components in the amounts shown in Table 1 were mixed using a universal mixer (5DM-L-03-r; DALTON CORPORATION), and the liquid-soluble components were dissolved in an optimal amount of water (equivalent to 13.5% of the mixture) and then added thereto. After further mixing and kneading for 2 minutes, the mixture was extruded and granulated through a screen with an opening diameter of 1.0 mm using a granulator (Multigran MG-55-2; DALTON CORPORATION), and the granulated product was dried at 80° C. using a dryer (FD-LAB-1; POWREX CORPORATION). Finally, the mixture was sieved using sieves with mesh sizes of 1.4 mm and 0.5 mm to obtain the agrochemical granule composition of the present invention and the comparative agrochemical granule composition. [Table 1]

[0111] Growth test of rice by pre-sowing soil covering at the time of sowing Using a small rice seedling box (approximately 1 / 12 the size of a normal seedling box, 30 cm x 60 cm), the test granule composition was applied at a rate of 8.3 g / seedling box before covering with soil at the time of sowing, and 12.5 g of dry rice grains (variety: Koshihikari) were sowed. After germination for 66 hours in a seedling tray (28 ° C all day), the seedlings were raised on a hotbed mat (20 ° C) in a vinyl house. After raising the seedlings for 21 days, the root strength of the rice (treated area) was measured. The root strength of the treated area was compared with that of the untreated area using Formula 1 to calculate the growth rate (%), and the growth status was evaluated according to the following criteria.

number

[0112] <<Criteria for determining growth status>> TIFF0007680374000003.tif42142 [Table 2]

[0113] The results of the above growth test on rice demonstrated that the pesticide granule composition of the present invention has an excellent phytotoxicity reducing effect.

Claims

1. Contains pesticide active ingredients, alkylnaphthalenesulfonic acid derivatives, pregelatinized starch, and smectite minerals. The pesticide active ingredient contains at least one of isotianil, penflufen, and tetraniliprole, The alkylnaphthalenesulfonic acid derivative includes a sodium salt of an alkylnaphthalenesulfonic acid formalin condensate.

1. A pesticide granule composition for application to rice seedling boxes, comprising:

2. 2. The pesticide granule composition according to claim 1, wherein the pesticide active ingredient is contained in an amount of 1 to 30 weight percent.

3. 3. The pesticide granule composition according to claim 1, wherein the content of the alkylnaphthalenesulfonic acid derivative is 0.1 to 2.0 weight percent.

4. The agrochemical granular composition according to any one of claims 1 to 3, wherein the content of pregelatinized starch is 0.1 to 10 weight percent.

5. The pesticide granular composition according to any one of claims 1 to 4, wherein the smectite mineral is bentonite.

6. The agrochemical granular composition according to any one of claims 1 to 5, wherein the content of the smectite mineral is 1 to 50 weight percent.

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