Antibacterial composition, medicinal solution, and method for producing medicinal solution

Abstract

The present invention provides an antibacterial composition having excellent antibacterial properties. The antibacterial composition according to the present invention is characterized by including: 100 parts by mass of calcined calcium; and 100-1,000 parts by mass of a compound of at least one component selected from the group consisting of zinc gluconate, copper gluconate, iron gluconate, glucono-delta-lactone, silicate, sodium hydrogen carbonate, N-(2-hydroxyethyl)ethylene diamine-N,N',N'-triacetic acid, diethylene triamine pentaacetic acid, triethylenetetramine-N,N,N',N'',N''',N'''-hexaacetic acid, nitrilotriacetic acid, N-(2-hydroxyethyl)imino diacetic acid , L-aspartic acid-N,N-diacetic acid, hydroxy imino disuccinic acid, aminotris methylenephosphonic acid, and 1-hydroxy ethane-1,1-diphosphonic acid.

Description

[Technical Field]

[0001] The present invention relates to antimicrobial compositions. [Background technology]

[0002] In recent years, with increasing awareness of hygienic environments, wet sheets or hand towels are used when eating indoors or outdoors. In addition, toilet cleaners are used to easily remove soiled areas after using the toilet.

[0003] Patent Document 2 discloses an antibacterial composition containing the following (A), (B), (C), (D) and (E): (A) Chitosan and / or its salt (B) 0.001 to 0.10 mass% of a quaternary ammonium salt (C) Alcohols (D) 0.01 to 1% by mass of a betaine-based amphoteric surfactant (E)Water [Prior art documents] [Patent documents]

[0004] [Patent Document 1] JP 2016-94410 A Summary of the Invention [Problem to be solved by the invention]

[0005] However, the antibacterial properties of the above antibacterial compositions are still insufficient, and there is a demand for antibacterial compositions with excellent antibacterial properties.

[0006] The present invention provides an antibacterial composition having excellent antibacterial properties. [Means for solving the problem]

[0007] The antibacterial composition of the present invention comprises: 100 parts by mass of calcined calcium, The composition is characterized by comprising 100 to 1000 parts by mass of at least one component compound selected from the group consisting of zinc gluconate, copper gluconate, iron gluconate, glucono-delta-lactone, silicates, sodium bicarbonate, N-(2-hydroxyethyl)ethylenediamine-N,N',N'-triacetic acid, diethylenetriaminepentaacetic acid, triethylenetetramine-N,N,N',N'',N''',N'''-hexaacetic acid, nitrilotriacetic acid, N-(2-hydroxyethyl)iminodiacetic acid, L-aspartic acid-N,N-diacetic acid, hydroxyiminodisuccinic acid, aminotrimethylenephosphonic acid, and 1-hydroxyethane-1,1-diphosphonic acid.

[0008] The antibacterial composition of the present invention comprises: 100 parts by mass of calcium hydroxide, The composition is characterized by comprising 100 to 1000 parts by mass of at least one component compound selected from the group consisting of zinc gluconate, copper gluconate, iron gluconate, glucono-delta-lactone, silicates, sodium bicarbonate, N-(2-hydroxyethyl)ethylenediamine-N,N',N'-triacetic acid, diethylenetriaminepentaacetic acid, triethylenetetramine-N,N,N',N'',N''',N'''-hexaacetic acid, nitrilotriacetic acid, N-(2-hydroxyethyl)iminodiacetic acid, L-aspartic acid-N,N-diacetic acid, hydroxyiminodisuccinic acid, aminotrimethylenephosphonic acid, and 1-hydroxyethane-1,1-diphosphonic acid. [Effects of the Invention]

[0009] The antibacterial composition of the present invention can be easily dissolved in water to produce a medicinal solution with little control over the conditions for dissolving in water, and the resulting medicinal solution has excellent antibacterial properties. DETAILED DESCRIPTION OF THE INVENTION

[0010] The antibacterial composition of the present invention contains calcined calcium and a component compound.

[0011] (calcined calcium) The antibacterial composition contains calcined calcium. Calcined calcium includes calcined calcium and a reaction product of calcined calcium with water (a reaction product of calcined calcium and water). The reaction product of calcined calcium with water can be obtained by reacting calcined calcium with water. The reaction product of calcined calcium with water can be produced, for example, by supplying calcined calcium to water. The reaction product of calcined calcium with water is preferably produced by supplying 0.05 to 1 part by mass of calcined calcium to 100 parts by mass of water, thereby reacting the calcined calcium with water. As the calcined calcium, calcined scallop shell calcium and a reaction product of calcined scallop shell calcium with water (a reaction product of calcined scallop shell calcium and water) are preferred.

[0012] Calcined calcium is obtained by calcining or electrically heating animal-derived calcium raw materials, such as oyster shells, scallop shells, surf clam shells, eggshells, coral shells, and fish bones, whose main component before calcination is calcium carbonate, at a temperature of 600°C or higher, preferably 900 to 1200°C, for approximately 15 to 60 minutes, and its main component is calcium oxide (usually 96% by mass or more).

[0013] As mentioned above, calcined calcium is mainly composed of calcium oxide. Instead of calcined calcium, a reaction product of calcium oxide with water (a reaction product of calcium oxide and water), i.e., calcium hydroxide, can be used.

[0014] (component compound) The antibacterial composition contains a component compound. The antibacterial composition contains 100 to 1000 parts by mass of the component compound relative to 100 parts by mass of the calcined calcium. By containing a predetermined amount of the component compound relative to the calcined calcium, the antibacterial composition has excellent antibacterial properties.

[0015] The component compounds include at least one component compound selected from the group consisting of zinc gluconate, copper gluconate, iron gluconate, glucono-delta-lactone, silicates, sodium bicarbonate, N-(2-hydroxyethyl)ethylenediamine-N,N',N'-triacetic acid, diethylenetriaminepentaacetic acid, triethylenetetramine-N,N,N',N'',N''',N'''-hexaacetic acid, nitrilotriacetic acid, N-(2-hydroxyethyl)iminodiacetic acid, L-aspartic acid-N,N-diacetic acid, hydroxyiminodisuccinic acid, aminotrimethylenephosphonic acid, and 1-hydroxyethane-1,1-diphosphonic acid. The component compounds may be used alone or in combination of two or more.

[0016] The component compound preferably contains at least one component compound selected from the group consisting of zinc gluconate, copper gluconate, iron gluconate, glucono-delta-lactone, silicates, and sodium bicarbonate, as this improves the antibacterial properties of the antibacterial composition.

[0017] The component compound more preferably contains at least one component compound selected from the group consisting of zinc gluconate, copper gluconate, and iron gluconate, as this improves the antibacterial properties of the antibacterial composition.

[0018] In the antibacterial composition, the content of the component compound is 100 to 1000 parts by mass per 100 parts by mass of the calcined calcium. When the content of the component compound is within the above range, the antibacterial composition has excellent antibacterial properties. When multiple types of component compounds are contained, the "content of the component compound" refers to the total content of the component compounds.

[0019] In the antibacterial composition, the content of zinc gluconate is 100 to 1,000 parts by mass, more preferably 100 to 600 parts by mass, more preferably 200 to 500 parts by mass, more preferably 250 to 400 parts by mass, and particularly preferably 260 to 350 parts by mass, per 100 parts by mass of calcined calcium. When the content of zinc gluconate is 100 parts by mass or more, the antibacterial properties of the antibacterial composition are improved. When the content of zinc gluconate is 1,000 parts by mass or less, the handleability of the chemical solution obtained by dissolving the antibacterial composition in water is improved.

[0020] In the antibacterial composition, the content of copper gluconate is 100 to 1000 parts by mass, more preferably 100 to 600 parts by mass, more preferably 200 to 500 parts by mass, more preferably 250 to 400 parts by mass, and particularly preferably 260 to 350 parts by mass, per 100 parts by mass of the calcined calcium. When the content of copper gluconate is within the above range, the antibacterial properties of the antibacterial composition are improved.

[0021] Examples of iron gluconate include ferrous gluconate and ferric gluconate, with ferrous gluconate being preferred. In the antibacterial composition, the content of iron gluconate is 100 to 1,000 parts by mass, more preferably 100 to 600 parts by mass, more preferably 200 to 500 parts by mass, more preferably 250 to 400 parts by mass, and particularly preferably 260 to 350 parts by mass, per 100 parts by mass of the calcined calcium. When the content of iron gluconate is within the above range, the antibacterial properties of the antibacterial composition are improved.

[0022] In the antibacterial composition, the content of glucono-delta-lactone is 100 to 1,000 parts by mass, more preferably 100 to 600 parts by mass, more preferably 200 to 500 parts by mass, more preferably 250 to 400 parts by mass, and particularly preferably 260 to 350 parts by mass, per 100 parts by mass of the calcined calcium. When the content of glucono-delta-lactone is within the above range, the antibacterial properties of the antibacterial composition are improved.

[0023] Examples of silicates include sodium silicate, sodium polysilicate, potassium silicate, and potassium polysilicate, with sodium silicate being preferred.

[0024] In the antibacterial composition, the content of the silicate is 100 to 1,000 parts by mass, more preferably 100 to 600 parts by mass, more preferably 130 to 590 parts by mass, more preferably 150 to 580 parts by mass, and particularly preferably 200 to 570 parts by mass, relative to 100 parts by mass of the calcined calcium. When the content of the silicate is 100 parts by mass or more, the antibacterial properties of the antibacterial composition are improved. When the content of the silicate is 1,000 parts by mass or less, the handleability of the chemical solution obtained by dissolving the antibacterial composition in water is improved.

[0025] In the antibacterial composition, the content of sodium bicarbonate (baking soda) is 100 to 1,000 parts by mass, more preferably 100 to 600 parts by mass, more preferably 130 to 590 parts by mass, more preferably 150 to 580 parts by mass, and particularly preferably 200 to 570 parts by mass, per 100 parts by mass of the calcined calcium. When the content of sodium bicarbonate is 100 parts by mass or more, the antibacterial properties of the antibacterial composition are improved. When the content of sodium bicarbonate is 1,000 parts by mass or less, the handleability of the chemical solution obtained by dissolving the antibacterial composition in water is improved.

[0026] In the antibacterial composition, the content of N-(2-hydroxyethyl)ethylenediamine-N,N',N'-triacetic acid (HEDTA) is 100 to 1000 parts by mass, more preferably 200 to 995 parts by mass, more preferably 250 to 993 parts by mass, more preferably 350 to 990 parts by mass, and particularly preferably 400 to 985 parts by mass, per 100 parts by mass of the calcined calcium. When the content of N-(2-hydroxyethyl)ethylenediamine-N,N',N'-triacetic acid is within the above range, the antibacterial properties of the antibacterial composition are improved.

[0027] In the antibacterial composition, the content of diethylenetriaminepentaacetic acid (DTPA) is 100 to 1000 parts by mass, more preferably 200 to 995 parts by mass, more preferably 250 to 993 parts by mass, more preferably 350 to 990 parts by mass, and particularly preferably 400 to 985 parts by mass, per 100 parts by mass of the calcined calcium. When the content of diethylenetriaminepentaacetic acid is within the above range, the antibacterial properties of the antibacterial composition are improved.

[0028] In the antibacterial composition, the content of triethylenetetramine-N,N,N',N'',N''',N'''-hexaacetic acid (TTHA) is 100 to 1000 parts by mass, more preferably 105 to 990 parts by mass, more preferably 106 to 980 parts by mass, more preferably 107 to 970 parts by mass, and particularly preferably 110 to 950 parts by mass, per 100 parts by mass of the calcined calcium. When the content of triethylenetetramine-N,N,N',N'',N''',N'''-hexaacetic acid is within the above range, the antibacterial properties of the antibacterial composition are improved.

[0029] In the antibacterial composition, the content of nitrilotriacetic acid (NTA) is 0.01 to 50 parts by mass, 100 to 1000 parts by mass, more preferably 200 to 995 parts by mass, more preferably 250 to 993 parts by mass, more preferably 350 to 990 parts by mass, and particularly preferably 400 to 985 parts by mass, relative to 100 parts by mass of the calcined calcium. When the content of nitrilotriacetic acid is within the above range, the antibacterial properties of the antibacterial composition are improved.

[0030] In the antibacterial composition, the content of N-(2-hydroxyethyl)iminodiacetic acid (HIDA) is 100 to 1000 parts by mass, more preferably 105 to 990 parts by mass, more preferably 550 to 980 parts by mass, more preferably 600 to 970 parts by mass, and particularly preferably 650 to 960 parts by mass, per 100 parts by mass of the calcined calcium. When the content of N-(2-hydroxyethyl)iminodiacetic acid is within the above range, the antibacterial properties of the antibacterial composition are improved.

[0031] In the antibacterial composition, the content of L-aspartic acid-N,N-diacetic acid (ADSA) is 100 to 1000 parts by mass, more preferably 105 to 990 parts by mass, more preferably 550 to 980 parts by mass, more preferably 600 to 970 parts by mass, and particularly preferably 650 to 960 parts by mass, per 100 parts by mass of the calcined calcium. When the content of L-aspartic acid-N,N-diacetic acid is within the above range, the antibacterial properties of the antibacterial composition are improved.

[0032] In the antibacterial composition, the content of hydroxyiminodisuccinic acid (HIDS) is 100 to 1000 parts by mass, more preferably 105 to 990 parts by mass, more preferably 550 to 980 parts by mass, more preferably 600 to 970 parts by mass, and particularly preferably 650 to 960 parts by mass, per 100 parts by mass of the calcined calcium. When the content of hydroxyiminodisuccinic acid is within the above range, the antibacterial properties of the antibacterial composition are improved.

[0033] In the antibacterial composition, the content of aminotrimethylene phosphonic acid (NTMP) is 100 to 1000 parts by mass, more preferably 105 to 990 parts by mass, more preferably 550 to 980 parts by mass, more preferably 600 to 970 parts by mass, and particularly preferably 650 to 960 parts by mass, per 100 parts by mass of the calcined calcium. When the content of aminotrimethylene phosphonic acid is within the above range, the antibacterial properties of the antibacterial composition are improved.

[0034] In the antibacterial composition, the content of 1-hydroxyethane-1,1-diphosphonic acid (HEDP) is 100 to 1,000 parts by mass, more preferably 105 to 990 parts by mass, more preferably 550 to 980 parts by mass, more preferably 600 to 970 parts by mass, and particularly preferably 650 to 960 parts by mass, per 100 parts by mass of the calcined calcium. When the content of 1-hydroxyethane-1,1-diphosphonic acid is within the above range, the antibacterial properties of the antibacterial composition are improved.

[0035] The component compound preferably contains at least one component compound selected from the group consisting of zinc gluconate, copper gluconate, iron gluconate, gluconate-delta-lactone, silicates, and sodium bicarbonate, as this improves the antibacterial properties of the antibacterial composition. The content of this component compound in the antibacterial composition is preferably 100 to 1,000 parts by mass, more preferably 100 to 600 parts by mass, more preferably 120 to 600 parts by mass, and particularly preferably 300 to 590 parts by mass, per 100 parts by mass of the calcined calcium. When the content of the component compound is within the above range, the antibacterial properties of the antibacterial composition are improved.

[0036] The component compound preferably contains at least one component compound selected from the group consisting of zinc gluconate, copper gluconate, and iron gluconate, as this improves the antibacterial properties of the antibacterial composition, and more preferably contains zinc gluconate, and even more preferably contains zinc gluconate, copper gluconate, and iron gluconate. The content of this component compound in the antibacterial composition is preferably 100 to 1,000 parts by mass, more preferably 100 to 600 parts by mass, more preferably 105 to 590 parts by mass, more preferably 108 to 580 parts by mass, and particularly preferably 110 to 570 parts by mass, per 100 parts by mass of the calcined calcium. When the content of the component compound is within the above range, the antibacterial properties of the antibacterial composition are improved.

[0037] When the component compounds contain zinc gluconate, copper gluconate, and / or iron gluconate, the component compounds preferably contain 50 to 90% by mass of zinc gluconate and 10 to 50% by mass of a total of copper gluconate and / or iron gluconate, and more preferably contain 60 to 90% by mass of zinc gluconate and 10 to 40% by mass of copper gluconate or iron gluconate. When the content of zinc gluconate is within the above range, the antibacterial properties of the antibacterial composition are improved. When the total content of copper gluconate and / or iron gluconate is within the above range, the antibacterial properties of the antibacterial composition are improved.

[0038] When the component compound contains zinc gluconate, copper gluconate, and iron gluconate, the component compound preferably contains 50 to 80 mass% zinc gluconate, 10 to 30 mass% copper gluconate, and 5 to 20 mass% iron gluconate. When the content of zinc gluconate is within the above range, the antibacterial properties of the antibacterial composition are improved. When the content of copper gluconate is within the above range, the antibacterial properties of the antibacterial composition are improved. When the content of copper gluconate is within the above range, the antibacterial properties of the antibacterial composition are improved.

[0039] The component compound preferably contains at least one component compound selected from the group consisting of N-(2-hydroxyethyl)ethylenediamine-N,N',N'-triacetic acid, diethylenetriaminepentaacetic acid, triethylenetetramine-N,N,N',N'',N''',N'''-hexaacetic acid, nitrilotriacetic acid, N-(2-hydroxyethyl)iminodiacetic acid, L-aspartic acid-N,N-diacetic acid, hydroxyiminodisuccinic acid, aminotrimethylenephosphonic acid, and 1-hydroxyethane-1,1-diphosphonic acid, because this improves the antibacterial properties of the antibacterial composition. The content of this component compound in the antibacterial composition is preferably 100 to 1,000 parts by mass, more preferably 105 to 995 parts by mass, more preferably 110 to 990 parts by mass, more preferably 200 to 950 parts by mass, more preferably 250 to 800 parts by mass, and particularly preferably 260 to 750 parts by mass, per 100 parts by mass of the calcined calcium. When the content of the component compound is within the above range, the antibacterial properties of the antibacterial composition are improved.

[0040] The antibacterial composition preferably further contains at least one alkali metal salt selected from the group consisting of alkali metal salts of citric acid and alkali metal salts of gluconic acid, which improves the antibacterial properties of the antibacterial composition.

[0041] The alkali metal salt of citric acid is not particularly limited, but sodium citrate and potassium citrate are preferred.

[0042] The alkali metal salt of gluconic acid is not particularly limited, but sodium gluconate and potassium gluconate are preferred.

[0043] The total content of at least one alkali metal salt selected from the group consisting of alkali metal salts of citric acid and alkali metal salts of gluconic acid in the antibacterial composition is preferably 200 to 1500 parts by mass, more preferably 300 to 1200 parts by mass, more preferably 350 to 1000 parts by mass, and particularly preferably 700 to 990 parts by mass, per 100 parts by mass of the calcined calcium. When the content of the alkali metal salt is within the above range, the antibacterial properties of the antibacterial composition are improved.

[0044] The antibacterial composition preferably contains, per 100 parts by mass of calcined calcium, 100 to 500 parts by mass of at least one component compound selected from the group consisting of zinc gluconate, copper gluconate, iron gluconate, gluconate delta-lactone, silicates, and sodium hydrogencarbonate, and 200 to 1,500 parts by mass of at least one alkali metal salt selected from the group consisting of alkali metal salts of citric acid and alkali metal salts of gluconic acid, in order to improve antibacterial properties.

[0045] The antibacterial composition more preferably contains, per 100 parts by mass of calcined calcium, 100 to 500 parts by mass of at least one component compound selected from the group consisting of zinc gluconate, copper gluconate, and iron gluconate, and 200 to 1,500 parts by mass of at least one alkali metal salt selected from the group consisting of alkali metal salts of citric acid and alkali metal salts of gluconic acid, as this improves the antibacterial properties.

[0046] The antibacterial composition more preferably contains, per 100 parts by mass of calcined calcium, 100 to 450 parts by mass of zinc gluconate, 15 to 200 parts by mass of at least one component compound selected from the group consisting of copper gluconate and iron gluconate, and 200 to 1,500 parts by mass of at least one alkali metal salt selected from the group consisting of alkali metal salts of citric acid and alkali metal salts of gluconic acid, as this improves the antibacterial properties.

[0047] The antibacterial composition preferably contains, per 100 parts by mass of calcined calcium, 100 to 450 parts by mass of zinc gluconate, 30 to 190 parts by mass of at least one component compound selected from the group consisting of copper gluconate and iron gluconate, and 200 to 1,500 parts by mass of at least one alkali metal salt selected from the group consisting of alkali metal salts of citric acid and alkali metal salts of gluconic acid, as this improves antibacterial properties.

[0048] The contents of the above-mentioned component compounds, alkali metal salts of citric acid, and alkali metal salts of gluconic acid are shown relative to 100 parts by mass of calcined calcium compounds. However, the contents relative to 100 parts by mass of calcium hydroxide and the reasons for these contents are the same, and therefore explanations thereof will be omitted.

[0049] As described above, the antibacterial composition contains calcined calcium compounds and component compounds in a predetermined mass ratio, thereby improving the antibacterial properties of the antibacterial composition. Furthermore, the antibacterial composition can be easily dissolved in water. In this case, the antibacterial composition can be easily dissolved by simply adding it to water, without precisely controlling the dissolution conditions, to produce a medicinal solution with antibacterial properties. The resulting medicinal solution hardly causes precipitation of the antibacterial composition, particularly the calcined calcium compounds, despite temperature changes. Even when calcium hydroxide is used, the antibacterial composition has the same effects as described above.

[0050] (Antibacterial composition) The antibacterial composition can be produced by mixing the calcined calcium compound and the component compound using a general-purpose mixing means. When calcium hydroxide is used, the antibacterial composition can be produced in the same manner as above.

[0051] The usage of the antibacterial composition will be described. The antibacterial composition can be dissolved in water to produce an antibacterial liquid. It is not necessary to carefully control the dissolution conditions when dissolving the antibacterial composition in water; the antibacterial composition can be easily dissolved in water simply by adding the antibacterial composition to water. The water may contain an aqueous solvent that is compatible with water. Examples of the aqueous solvent include alcohols such as methanol, ethanol, and propyl alcohol, and ketones such as dimethyl ketone and methyl ethyl ketone. When the water contains an aqueous solvent that is compatible with water, the content of the water is preferably 50% by mass or more, more preferably 60% by mass or more, more preferably 70% by mass or more, more preferably 80% by mass or more, and even more preferably 90% by mass or more of the total amount of water and the aqueous solvent.

[0052] In producing the chemical solution, the order of mixing calcined calcium and / or a reaction product of calcined calcium with water (a reaction product of calcined calcium and water), the component compounds, water, and other additives added as needed is not particularly limited. Similarly, when calcium hydroxide is used, the order of mixing is not particularly limited.

[0053] The content of the antibacterial composition in the chemical solution is preferably 0.01 to 10 parts by mass, more preferably 0.05 to 5 parts by mass, more preferably 0.07 to 3 parts by mass, and particularly preferably 0.08 to 2 parts by mass, per 100 parts by mass of water.

[0054] The resulting solution hardly produces any precipitation of the antibacterial composition, particularly precipitation of calcined calcium compounds or calcium hydroxide. Therefore, there is almost no need to filter out the precipitates when using the solution, which simplifies the equipment and manufacturing process.

[0055] Furthermore, the obtained drug solution can be stably stored without deterioration and maintains its excellent antibacterial activity for a long period of time without the addition of a preservative. Examples of preservatives include commonly used ones such as parahydroxybenzoic acid esters or their salts (parabens), phenoxyethanol, benzoic acid or its salts, sorbic acid or its salts, and chlorhexidine gluconate.

[0056] An antibacterial sheet can be produced by impregnating a fabric (nonwoven fabric, woven fabric, knitted fabric, etc.) with the chemical solution. The antibacterial sheet can be used, for example, as a hand towel, a cleaning sheet, a toilet cleaner, etc.

[0057] Furthermore, since the antibacterial composition does not contain compounds harmful to the human body, by soaking food items such as vegetables and fruits in the chemical solution, antibacterial properties can be imparted to the food items, thereby improving the shelf life of the food items.

[0058] Furthermore, the chemical solution can be used as a cleanser, and the body can be cleaned by wiping the hands, feet, etc. with the chemical solution.

[0059] Furthermore, since hair washing agents (shampoos), hair rinses, and body cleansers contain water, by dissolving the antibacterial composition in water, it is possible to impart antibacterial properties to the hair washing agents, hair rinses, and cleansers, and the hair washing agents, hair rinses, and cleansers can be stored stably for a long period of time.

[0060] The antibacterial composition can be incorporated into an aqueous paint to impart antibacterial properties to the aqueous paint. The aqueous paint contains water and a binder component dispersed in the water. The antibacterial composition can be easily dissolved in water, so that the antibacterial composition can be uniformly incorporated into the aqueous paint, and the resulting coating film can be uniformly incorporated to form a coating film having antibacterial properties.

[0061] The antibacterial composition can also be incorporated into cosmetics to impart antibacterial properties to the cosmetics. The cosmetics may contain water, such as lotions.

[0062] The antibacterial composition may also be kneaded into a synthetic resin. The antibacterial composition and the synthetic resin are fed into an extruder, melt-kneaded, and extruded from the extruder to form a molded article of a desired shape (for example, a sheet, a food storage bag, daily necessities, a vehicle interior material, or a building interior material), thereby obtaining a molded article having antibacterial properties. [Example]

[0063] The present invention will be described in more detail below using examples, but the present invention is not limited to these examples.

[0064] ( Examples 1 to 9, 46 to 63, 85 to 96, and 109 to 142, Reference Examples 10 to 45, 64 to 84, and 97 to 108, and Comparative Examples 1 to 32) Scallop calcined calcium was prepared as the calcined calcium. The component compounds were zinc gluconate, copper gluconate, iron gluconate, glucono-delta-lactone, sodium silicate, sodium bicarbonate, N-(2-hydroxyethyl)ethylenediamine-N,N',N'-triacetic acid (HEDTA), diethylenetriaminepentaacetic acid (DTPA), triethylenetetramine-N,N,N',N'',N''',N'''-hexaacetic acid (TTHA), nitrilotriacetic acid (NTA), N-(2-hydroxyethyl)iminodiacetic acid (HIDA), L-aspartic acid-N,N-diacetic acid (ADSA), hydroxyiminodisuccinic acid (HIDS), aminotrimethylenephosphonic acid (NTMP), and 1-hydroxyethane-1,1-diphosphonic acid (HEDP). The calcium oxide content in the calcined scallop calcium was 99.9% by mass.

[0065] Sodium citrate and potassium citrate were prepared as alkali metal salts of citric acid, and sodium gluconate and potassium gluconate were prepared as alkali metal salts of gluconic acid.

[0066] Antibacterial compositions were prepared by mixing calcined scallop calcium, component compounds, alkali metal citric acid salts, and alkali metal gluconic acid salts in the prescribed amounts shown in Tables 1 to 8.

[0067] The antibacterial properties of the obtained antibacterial compositions were measured in the following manner, and the results are shown in Tables 1 to 7.

[0068] (Antibacterial) One part by mass of the antibacterial composition was added to 100 parts by mass of water and dissolved to prepare a drug solution. This drug solution was designated as test sample A. Escherichia coli was inoculated onto a nutrient agar medium and cultured at 35°C for 24 hours. After the culture, the mixture was immersed in 10 ml of sterile saline. 7 The solution was adjusted to / mL and used as the test bacterial solution.

[0069] 100 μL of the test bacteria solution was inoculated into 200 mL of test sample A and cultured at 25°C. Five and 30 minutes after inoculation, a 10-fold serial dilution of test sample A was prepared using sterile physiological saline to prepare test solutions, which were then inoculated onto SCDLP agar medium and cultured at 35°C for 48 hours. After culture, the formed colonies were counted and converted into the viable bacterial count (cfu / mL).

[0070] In addition, the test was conducted in the same manner as above using sterile phosphate buffered saline as a control, and the viable cell count was converted into the initial cell count (cfu / mL). The antibacterial activity was calculated using the following formula and evaluated according to the following criteria. Antibacterial property (%) = 100 × (initial number of bacteria - number of viable bacteria) / (initial number of bacteria)

[0071] A: It was over 95%. B: Over 90% and under 95%. C: More than 80% and less than 90%. D: 70% or more and less than 80%. E: Less than 70%.

[0072] A predetermined amount of calcined calcium (calcined scallop calcium) shown in Tables 1 to 8 was added to 1,000 parts by mass of water, and the calcined calcium and water were reacted to produce a reaction product of calcined calcium with water. The predetermined amounts of the component compounds, alkali metal salts of citric acid, and alkali metal salts of gluconic acid shown in Tables 1 to 8 were added to the water containing the reaction product of calcined calcium and water, and the component compounds, alkali metal salts of citric acid, and alkali metal salts of gluconic acid were dissolved in the water to produce a medicinal solution. The antibacterial properties of this medicinal solution, designated as Test Sample B, were measured in the same manner as Test Sample A. The antibacterial properties of Test Sample B were evaluated to be identical to those of Test Sample A, which had the same composition of water, calcined calcium, component compounds, alkali metal salts of citric acid, and alkali metal salts of gluconic acid.

[0073] An antibacterial composition was prepared by using calcium hydroxide instead of calcined calcium and mixing calcium hydroxide (calcined calcium amounts in Tables 1 to 8), component compounds, alkali metal salts of citric acid, and alkali metal salts of gluconic acid in the prescribed amounts shown in Tables 1 to 8. The antibacterial properties of this antibacterial composition were measured in the same manner as above, and the results were the same as those of test sample A, which used calcined calcium instead of calcium hydroxide and contained the same amounts of water, calcined calcium, component compounds, alkali metal salts of citric acid, and alkali metal salts of gluconic acid.

[0074] [Table 1]

[0075] [Table 2]

[0076] [Table 3]

[0077] [Table 4]

[0078] [Table 5]

[0079] [Table 6]

[0080] [Table 7]

[0081] [Table 8] [Industrial Applicability]

[0082] The antibacterial composition of the present invention can be easily dissolved in water to produce a medicinal solution. The medicinal solution can be used to produce an antibacterial sheet or to impart antibacterial properties to food products. The medicinal solution can also be used as a cleaning agent. By incorporating the antibacterial composition into objects such as cleaning agents, water-based paints, cosmetics, and synthetic resins, antibacterial properties can be imparted to the objects.

[0083] (CROSS-REFERENCE TO RELATED APPLICATIONS) This application claims priority based on Japanese Patent Application No. 2019-83320 filed on April 24, 2019, and Japanese Patent Application No. 2019-169915 filed on September 18, 2019, the disclosures of which are incorporated herein by reference in their entireties.

Claims

1. 100 parts by mass of calcined calcium or 100 parts by mass of calcium hydroxide, and 100 to 600 parts by mass of at least one component compound selected from the group consisting of zinc gluconate, copper gluconate, and iron gluconate, An antibacterial composition characterized by containing the above component compounds in an amount of (100 / 280) mass % or more.

2. 100 parts by mass of calcined calcium or 100 parts by mass of calcium hydroxide, and 100 to 600 parts by mass of at least one component compound selected from the group consisting of zinc gluconate, copper gluconate, and iron gluconate, The component compound is contained in an amount of 100 / 900% by mass or more, An antibacterial composition comprising 200 to 1,500 parts by mass of at least one alkali metal salt selected from the group consisting of alkali metal salts of citric acid and alkali metal salts of gluconic acid.

3. A chemical solution comprising the antibacterial composition according to claim 1 or 2 dissolved in water.

4. 100 parts by mass of calcined calcium or 100 parts by mass of calcium hydroxide, and 100 to 600 parts by mass of at least one component compound selected from the group consisting of zinc gluconate, copper gluconate, and iron gluconate, an antibacterial composition containing the above component compounds in an amount of (100 / 280) mass% or more; A method for producing a chemical solution, comprising mixing the chemical solution with water.

5. 100 parts by mass of calcined calcium or 100 parts by mass of calcium hydroxide, and 100 to 600 parts by mass of at least one component compound selected from the group consisting of zinc gluconate, copper gluconate, and iron gluconate, The component compound is contained in an amount of 100 / 900% by mass or more, an antibacterial composition comprising 200 to 1,500 parts by mass of at least one alkali metal salt selected from the group consisting of alkali metal salts of citric acid and alkali metal salts of gluconic acid; A method for producing a chemical solution, comprising mixing the chemical solution with water.

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