Blood purification device, information processing device, water removal profile setting method, and processing program

Abstract

To enable a water removal process that can be adapted to various patients and reduces the burden on the patients while simplifying the process of setting a water removal profile. [Solution] The system has a calculation unit that sets a water removal profile based on the treatment time, the target water removal volume, a specified elapsed time since the start of treatment, the target water removal achievement rate at the specified elapsed time, and the time required to reach the set water removal speed in blood purification treatment, and the calculation unit is equipped with a set water removal speed acquisition unit that acquires the set water removal speed, a specified time water removal speed acquisition unit that acquires the specified time water removal speed at the specified elapsed time, and a start and end water removal speed calculation unit that calculates the start and end water removal speeds based on the section-specific water removal volumes for each section.

Description

[Technical Field]

[0001] The present disclosure relates to controlling water removal during blood purification treatment for a patient. [Background technology]

[0002] As an example of blood purification, dialysis treatment using a blood purification device having a dialyzer and a blood circuit has been known. In dialysis treatment, blood taken from a patient is circulated extracorporeally through a blood circuit, purified using a dialyzer connected to the blood circuit, and the purified blood is returned to the patient. During the blood purification, excess water and waste products are removed from the patient's body.

[0003] In the water removal process to remove such excess water, the amount and speed of water removal are very important. If the amount and speed of water removal are not appropriate, it may cause a drop in blood pressure, muscle cramps, headaches, nausea, vomiting, or loss of consciousness, placing a great burden on the patient during treatment. For this reason, the amount and speed of water removal are set appropriately, taking into account the patient's condition, etc.

[0004] For example, Patent Documents 1 to 4 disclose that the water removal rate, which is normally controlled to a constant value, is reduced from the start of treatment to the end of treatment. In particular, Patent Document 1 discloses that the water removal rate is gradually reduced and then controlled to remain constant for one hour after the reduction. Patent Document 2 discloses that water removal control is divided into two stages, and that in the latter stage when the water removal rate is reduced, water removal control is performed according to the rate of change in circulating blood volume or blood pressure. Furthermore, Patent Documents 3 and 4 disclose that water removal control is performed so that the water removal rate asymptotically approaches a target value. [Prior art documents] [Patent documents]

[0005] [Patent Document 1] Japanese Utility Model Application Publication No. 5-76445 [Patent Document 2] Japanese Patent Application Laid-Open No. 2007-143815 [Patent Document 3] Japanese Patent Application Laid-Open No. 2005-6980 [Patent Document 4] Japanese Patent Application Laid-Open No. 2004-49492 Summary of the Invention [Problem to be solved by the invention]

[0006] However, simply decreasing the water removal rate over time can be insufficient to reduce the burden on patients. Furthermore, attempting to set a more optimal water removal profile requires a greater number of settings or selections, sometimes resulting in settings that are difficult to set or select. In other words, there is considerable room for improvement in controlling the water removal rate from the start to the end of treatment in terms of reducing the burden on patients, and medical professionals providing treatment have expressed a desire for simplified setting procedures.

[0007] The present disclosure has been made in consideration of these problems, and its purpose is to provide a blood purification device, an information processing device, a water removal profile setting method, and a processing program that enable water removal processing that can accommodate a variety of patients and reduce the burden on patients, while simplifying the water removal profile setting process. [Means for solving the problem]

[0008] According to one aspect of the present disclosure, there is provided a blood purification device for administering blood purification treatment to a patient, the blood purification device having a calculation unit that sets a water removal profile based on the treatment time of the blood purification treatment, the target water removal amount in the blood purification treatment, the target water removal achievement rate in a predetermined elapsed time since the start of the blood purification treatment, and the set water removal rate arrival time required to reach the set water removal rate in the blood purification treatment, the calculation unit comprising: a set water removal rate acquisition unit that acquires the set water removal rate; a predetermined time water removal rate acquisition unit that acquires the predetermined time water removal rate in the predetermined elapsed time; and an initial and final water removal rate calculation unit that divides the treatment time into sections based on the predetermined elapsed time and the set water removal rate arrival time, and calculates an initial water removal rate and an final water removal rate based on the section-specific water removal rate for each section.

[0009] According to one aspect of the present disclosure, there is provided an information processing device that performs setting processing for blood purification treatment for a patient, the information processing device having a calculation unit that sets a water removal profile based on the treatment time of the blood purification treatment, the target water removal amount in the blood purification treatment, the target water removal achievement rate in a specified elapsed time since the start of the blood purification treatment, and the set water removal rate arrival time for reaching the set water removal rate in the blood purification treatment, the calculation unit comprising: an equal water removal rate acquisition unit that acquires the set water removal rate; a specified time water removal rate acquisition unit that acquires the specified time water removal rate in the specified elapsed time; and an initial and final water removal rate calculation unit that divides the treatment time into sections based on the specified elapsed time and the set water removal rate arrival time, and calculates the initial water removal rate and final water removal rate based on the section-specific water removal achievement rate of each section.

[0010] According to one aspect of the present disclosure, there is provided a "water removal profile setting method in which a calculation unit sets a water removal profile for controlling a water removal pump in blood purification treatment for a patient, the water removal profile setting method comprising: an acquisition step of acquiring the treatment time of the blood purification treatment, the target water removal amount in the blood purification treatment, the target water removal achievement rate in a predetermined elapsed time since the start of the blood purification treatment, and the set water removal rate arrival time until the set water removal rate in the blood purification treatment is reached; a set water removal rate acquisition step of acquiring the set water removal rate; a predetermined time water removal rate acquisition step of acquiring the predetermined time water removal rate in the predetermined elapsed time; an initial and final water removal rate calculation step of dividing the treatment time into sections based on the predetermined elapsed time and the set water removal rate arrival time, and calculating an initial and final water removal rate based on the section-by-section water removal achievement rate of each section; and a setting step of setting a water removal profile from the treatment time, the predetermined elapsed time, the set water removal rate, the predetermined time water removal rate, the initial water removal rate, and the final water removal rate."

[0011] According to one aspect of the present disclosure, there is provided a processing program for performing setting processing for blood purification treatment for a patient, the processing program acquiring the treatment time for the blood purification treatment, the target water removal amount for the blood purification treatment, the target water removal achievement rate at a predetermined elapsed time after the start of the blood purification treatment, and the set water removal rate arrival time for the set water removal rate for the blood purification treatment, acquiring the set water removal rate, acquiring the predetermined time water removal rate at the predetermined elapsed time, dividing the treatment time into sections based on the predetermined elapsed time and the time to reach the set water removal rate, calculating the initial water removal rate and the final water removal rate based on the section-by-section water removal achievement rate for each section, and causing a calculation unit to execute processing to set a water removal profile from the treatment time, the predetermined elapsed time, the set water removal rate, the predetermined time water removal rate, the initial water removal rate, and the final water removal rate. [Effects of the Invention]

[0012] According to the present disclosure, it is possible to provide a blood purification device, an information processing device, a water removal profile setting method, and a processing program that enable water removal processing that can be used for a variety of patients and reduces the burden on patients, while simplifying the water removal profile setting process.

[0013] It should be noted that the above effects are merely examples for the sake of convenience of explanation, and the effects of the present disclosure are not limited to these. In addition to the above effects, the present disclosure can achieve any of the effects described herein. [Brief explanation of the drawings]

[0014] [Figure 1] FIG. 1 is a schematic diagram showing the mechanical configuration of a blood purification unit according to a first embodiment. [Figure 2] FIG. 2 is a block diagram showing the electrical configuration of the blood purification unit according to the first embodiment. [Figure 3] FIG. 2 is a schematic diagram showing the mechanical configuration of the extracorporeal circulation section and internal piping section of the blood purification unit according to the first embodiment. [Figure 4] 3 is an example of a data table stored in the blood purification unit according to the first embodiment. [Figure 5] 4 is a graph showing an example of a water removal profile of the blood purification unit according to the first embodiment. [Figure 6] 4 is a graph showing an example of a water removal profile of the blood purification unit according to the first embodiment. [Figure 7] FIG. 1 is a functional block diagram of a blood purification unit according to a first embodiment. [Figure 8] FIG. 3 is a flowchart showing the flow of processing related to setting a water removal profile for the blood purification unit according to the first embodiment. [Figure 9] 1 is an input screen for setting items of a water removal profile displayed in the blood purification unit according to the first embodiment. [Figure 10] FIG. 3 is a flowchart showing the flow of processing related to setting a water removal profile for the blood purification unit according to the first embodiment. [Figure 11]4 is a graph showing an overview of calculation processing related to setting of a water removal profile for the blood purification unit according to the first embodiment. [Figure 12] 4 is a graph showing an overview of calculation processing related to setting of a water removal profile for the blood purification unit according to the first embodiment. [Figure 13] 4 is a graph showing an overview of calculation processing related to setting of a water removal profile for the blood purification unit according to the first embodiment. [Figure 14] 4 is a graph showing an overview of calculation processing related to setting of a water removal profile for the blood purification unit according to the first embodiment. [Figure 15] 4 is a graph showing an overview of calculation processing related to setting of a water removal profile for the blood purification unit according to the first embodiment. [Figure 16] 4 is a graph showing an overview of calculation processing related to setting of a water removal profile for the blood purification unit according to the first embodiment. [Figure 17] 10 is a graph showing a modified example of the water removal profile of the blood purification unit according to the first embodiment. [Figure 18] 10 is a graph showing a modified example of the water removal profile of the blood purification unit according to the first embodiment. [Figure 19] FIG. 10 is a flowchart showing the flow of processing related to setting a water removal profile for a blood purification unit according to a second embodiment. [Figure 20] 10 is an input screen for setting items of a water removal profile displayed in the blood purification unit according to the second embodiment. [Figure 21] 10 is an input screen for setting items of a water removal profile displayed in the blood purification unit according to the second embodiment. [Figure 22] 10 is an input screen for setting items of a water removal profile displayed in the blood purification unit according to the second embodiment. [Figure 23] FIG. 11 is a flowchart showing the flow of processing related to setting a water removal profile for a blood purification unit according to a third embodiment. [Figure 24] 10 is an input screen for setting items of a water removal profile displayed in the blood purification unit according to the third embodiment. [Figure 25] FIG. 10 is a schematic diagram showing the mechanical configuration of a blood purification system according to a fourth embodiment. [Figure 26] 10 is a functional block diagram of a blood purification system according to a fourth embodiment. FIG. DETAILED DESCRIPTION OF THE INVENTION

[0015] The blood purification device and blood purification unit including the same according to the present disclosure will be described in detail below with reference to the drawings. The present disclosure is not limited to the content described below and can be modified as desired without departing from the spirit and scope of the present disclosure. The drawings used in each embodiment are schematic illustrations of the blood purification device, its components, and the blood purification unit including these components according to the present disclosure. To facilitate understanding, some parts may be emphasized, enlarged, reduced, or omitted, and the scale and shape of each component may not be accurately represented. Furthermore, some numerical values ​​used in each embodiment are merely examples and can be modified as necessary. The same reference symbols are used to designate components that are common to all drawings.

[0016] First Embodiment (Blood purification unit configuration) First, the configuration of the blood purification unit of the present disclosure will be described with reference to Figures 1 to 6. Figure 1 is a schematic diagram showing the mechanical configuration of the blood purification unit according to this embodiment. Figure 2 is a block diagram showing the electrical configuration of the blood purification unit according to this embodiment. Figure 3 is a schematic diagram showing the mechanical configuration of the extracorporeal circulation section and internal piping section of the blood purification unit according to this embodiment. Figure 4 is an example of a data table stored in the blood purification unit according to this embodiment. Figures 5 and 6 are graphs showing an example of a water removal profile of the blood purification unit according to this embodiment.

[0017] 1, the blood purification unit 1 is composed of a blood purification apparatus 1a, which is a dialysis device for performing dialysis treatment, which is an example of blood purification treatment, and a consumables section 1b, which is composed of various consumables. That is, in the blood purification unit 1, a state is created in which the consumables section 1b is connected to the blood purification apparatus 1a, and dialysis treatment is performed on patient H.

[0018] Specifically, the blood purification unit 1 has a main body 3 installed on a base unit 2, a display 4 connected to the top of the main body 3, and a blood purifier 5 installed to the side of the main body 3. The main body 3 of the blood purification unit 1 also has an information processing unit 6 that processes various information and data, an internal piping unit 7 for circulating dialysate between the main body and the blood purifier 5, and an extracorporeal circulation unit 8 for circulating the blood, which is a bodily fluid of patient H, outside the body. With this configuration, the blood purification unit 1 can extract the blood of patient H from the body (blood removal process), remove unnecessary or toxic substances or water from the blood in the blood purifier 5 (blood purification process), and return the purified blood to patient H (blood return process).

[0019] The blood purification device 1a is the base of the blood purification unit 1 and is composed of a base unit 2, a main body 3, a display 4, an information processing unit 6, an internal piping unit 7, and part of an extracorporeal circulation unit 8. Here, the extracorporeal circulation unit 8 includes a blood circuit (described later), a pump connected to the blood circuit, various sensors, and other parts and devices. Of these, the pump, various sensors, and other devices are provided in the blood purification device 1a and therefore become components (constituent devices) of the blood purification device 1a.

[0020] On the other hand, the consumables section 1b is composed of the blood purifier 5 and part of the extracorporeal circulation section 8. Here, the blood circuit and some of the other components included in the extracorporeal circulation section 8 are merely detachably connected to the blood purification device 1a, and are elements (components) that make up the consumables section 1b, not the blood purification device 1a.

[0021] As shown in Figure 2, the blood purification unit 1 is electrically connected to the display 4, information processing unit 6, internal piping unit 7, and extracorporeal circulation unit 8 via control lines and data lines. This allows the blood purification device 1a to transmit and receive various signals, data, and information, and also enables various controls by the information processing unit 6. In the following, data is basically assumed to consist of processed signals, such as numbers, symbols, or characters. Information is basically assumed to be collected or processed data, such as data that the recipient can use for subsequent consideration or that can be utilized by the recipient. However, data and information may be used in accordance with their content and context, regardless of the above assumptions.

[0022] In this embodiment, a hemodialysis device is described as an example of the blood purification device 1a, but the blood purification device 1a is not limited to this. For example, an acute blood purification device, a peritoneal dialysis device, an ultrafiltration device, or a hemofiltration device can also be an example of the blood purification device 1a.

[0023] In addition to the above-described configuration, the blood purification apparatus 1a of the blood purification unit 1 may have a communication interface that enables transmission and reception of information and the like with an external device such as a terminal device or a server device, etc. This allows the blood purification apparatus 1a to obtain various information related to the patient's treatment (patient information) from the external device via the communication interface.

[0024] [Base unit] As shown in Fig. 1, the base unit 2 is composed of a plate-shaped base 2a connected to the bottom of the main body 3 and four casters 2b attached to the base 2a. This allows the blood purification unit 1 and blood purification device 1a to be easily moved. The number of casters 2b is not limited to four, and may be three or five or more as long as it allows the blood purification unit 1 and blood purification device 1a to be moved.

[0025] [Main unit] 1, the main body 3 is composed of a substantially rectangular parallelepiped housing. Inside and on the surface of the main body 3, various components and devices that constitute the internal piping section 7 and extracorporeal circulation section 8 of the blood purification unit 1 are arranged. For example, the components may include various pumps and detectors, and the components may include a blood circuit, a dialysate circuit, and various sensors.

[0026] 〔display〕 1 and 2, the display 4 has a touch panel input interface 4a and a general screen output interface 4b. That is, the display 4 in this embodiment is a touch panel equipped with an input / output interface. The input detection method by the touch panel may be any method, such as a capacitance method or a resistive film method. The operable area and position on the touch panel can be freely set by the administrator of the blood purification unit 1. That is, the arrangement of the input interface 4a and output interface 4b on the display 4 can be set as appropriate.

[0027] The input interface 4a may be separated from the display 4. In this case, the blood purification apparatus 1a may be provided with an input device such as a keyboard with physical key buttons, such as a numeric keypad or character input keys, and a mouse.

[0028] [Blood purifier] 1 and 3, the blood purifier 5 has a blood inlet 5a and a blood outlet 5b at both ends of its housing as blood-side ports, and a dialysate inlet 5c and a dialysate outlet 5d at the side of its housing as dialysate-side ports. An arterial blood circuit L1 (described later) is connected to the blood inlet 5a, and a venous blood circuit L2 (described later) is connected to the blood outlet 5b. A dialysate supply pipe (drug solution supply pipe) L3 (described later) is connected to the dialysate inlet 5c, and a dialysate discharge pipe (drug solution discharge pipe) L4 (described later) is connected to the dialysate outlet 5d.

[0029] The blood purifier 5 contains a plurality of hollow fiber membranes (not shown), which constitute a blood purification membrane for purifying blood. Inside the blood purifier 5, a blood flow path through which the blood of patient H flows via the blood purification membrane and a dialysate flow path through which a dialysate, a medicinal solution for blood purification, flows are formed. Furthermore, the hollow fiber membranes constituting the blood purification membranes have many minute pores formed therein that penetrate from the outer peripheral surface to the inner peripheral surface, allowing impurities in the blood to permeate into the dialysate via the hollow fiber membranes.

[0030] The blood purifier 5 is not limited to a dialyzer having the above-described configuration. For example, it may be an adsorption-type blood purifier used in endotoxin adsorption therapy, activated carbon adsorption therapy, bilirubin adsorption therapy, etc. The blood purifier 5 may also be a hemodiafilter.

[0031] [Extracorporeal circulation department] Next, as shown in FIG. 3, the extracorporeal circulation unit 8 has a structure in which an arterial blood circuit L1 is connected to the blood inlet side of the blood purifier 5, and a venous blood circuit L2 is connected to the blood outlet side of the blood purifier 5. That is, the arterial blood circuit L1 and the venous blood circuit L2 constitute a blood circuit L0 through which the patient's blood flows. A gas circuit L21 for adjusting the liquid level of an air trap chamber (described later) is connected to branch off from the venous blood circuit L2. Here, the gas circuit L21 functions as an open line for introducing or discharging air into or from the air trap chamber. Each of these circuits is made of a flexible material, such as polyvinyl chloride tubing or silicone tubing. That is, the arterial blood circuit L1, the venous blood circuit L2, and the gas circuit L21 are flexible fluid lines for fluid flow.

[0032] The arterial blood circuit L1 has, for example, a connector C1 disposed at one end thereof and a blood pump P1 disposed midway along the connector C1. The type of blood pump P1 is not particularly limited as long as it can introduce the blood of the patient H into the blood purifier 5. In this embodiment, a peristaltic pump is assumed, but other pumps such as a diaphragm pump may also be used.

[0033] For the sake of convenience, some of the components and devices provided in the arterial blood circuit L1 are omitted from the description of this disclosure, and various components, devices, and equipment required for blood purification are provided as appropriate. For example, depending on the specifications of the blood purification device 1a and the blood circuit L0, the arterial blood circuit L1 may be provided with a valve (solenoid valve), an air bubble detector, an air trap chamber, and the like.

[0034] On the other hand, in the venous blood circuit L2, for example, an air trap chamber 22 and a connector C2 are arranged in this order from the blood purifier 5 toward the patient H.

[0035] For the sake of convenience, some components arranged in the venous blood circuit L2 are omitted from the description of this disclosure. Various components, devices, and apparatuses necessary for blood purification are arranged as appropriate. For example, depending on the specifications of the blood purification apparatus 1a and the blood circuit L0, a pressure detector, an air bubble detector, a valve, and the like may be arranged. When the blood purification apparatus 1a is driven to purify the blood of patient H, an arterial puncture needle (not shown) is connected to connector C1, and a venous puncture needle (not shown) is connected to connector C2, and each puncture needle is inserted into the arm of patient H.

[0036] The gas circuit L21 for adjusting the liquid level is provided with a valve V1, a pressure sensor S1, an air pump P2 for adjusting the liquid level, and an air filter 24, arranged in this order from the air trap chamber 22 toward the outside of the circuit. This configuration makes it possible to drive the air pump P2 to introduce or expel air, thereby adjusting the blood level in the air trap chamber 22. Some of the components arranged in the gas circuit L21 are omitted here for the sake of convenience in explaining this disclosure, and various components, devices, and apparatuses required for adjusting the liquid level are arranged as appropriate.

[0037] The operations of the various pumps and valve V1 described above are controlled based on control signals supplied from the information processing unit 6. Furthermore, these various pumps and valve V1 can transmit data indicating their operating states to the information processing unit 6. This enables the information processing unit 6 to control the operations of the components of the extracorporeal circulation unit 8 and to grasp various states of the extracorporeal circulation unit 8.

[0038] As described above, the extracorporeal circulation unit 8 is assembled by appropriately selecting the above-mentioned parts and devices according to the circuit configuration and model, and has a structure that enables blood removal and return. Also, the extracorporeal circulation unit 8 is assembled by appropriately selecting the above-mentioned parts and devices according to the circuit configuration and model, and has a structure that detects the amount of blood.

[0039] [Internal piping section] Next, as shown in Fig. 3, the internal piping section 7 has a structure in which a main pipe (dialysate supply pipe) L3 is connected to the supply side of the blood purifier 5, a main pipe (dialysate discharge pipe) L4 is connected to the discharge side, and a bypass pipe L31 is connected between the main pipe L3 and the main pipe L4 so as to bypass the blood purifier 5. In addition, a bypass pipe L41 is connected in parallel to the main pipe L4 midway through the main pipe L4 so as to bypass a portion of the main pipe L4. For example, each pipe is made of a flexible material such as polyvinyl chloride tubing or silicone tubing. That is, the main pipe L3, the main pipe L4, the bypass pipe L31, and the bypass pipe L41 constitute the dialysate pipe L50 through which the dialysate flows, and serve as a flexible fluid line for fluid flow.

[0040] As can be seen from FIG. 3 , each pipe is provided with a pump, a valve, a sensor, and the like. Specifically, in the main pipe L3, a degassing pump P11, which is one of the dialysis fluid pumps, a duplex pump P12, which is one of the dialysis pumps, a pressure sensor S11, and a valve V11 are arranged in this order from the fluid supply terminal side of the internal pipe section 7 toward the dialysate inlet 5c of the blood purifier 5. Here, some of the components and devices arranged in the main pipe L3 are omitted for the convenience of explanation of this disclosure, and various components, devices, and apparatuses necessary for blood purification are arranged as appropriate. For example, depending on the specifications of the blood purification device 1a and the dialysate pipe L50, other valves (pressure reducing valves, solenoid valves, back pressure valves), chambers, filters, temperature sensors, and the like may be arranged in the main pipe L3.

[0041] In addition, in the main pipe L4, a valve V12, a pressure sensor S12, a pressure pump P13 which is one of the dialysate pumps, and a duplex pump P12 are arranged in this order from the dialysate outlet 5d of the blood purifier 5 toward the drain terminal side of the internal pipe section 7. Here, some of the components and devices arranged in the main pipe L4 are omitted for the convenience of explanation in this disclosure, and various components, equipment, and devices necessary for blood purification are arranged as appropriate. For example, depending on the specifications of the blood purification device 1a and the dialysate pipe L50, other valves (solenoid valves, back pressure valves), a degassing chamber, a flow rate detector, etc. may be arranged in the main pipe L4.

[0042] Furthermore, a valve V13 is provided in the bypass pipe L31. A water removal pump P14, which is one of the dialysis fluid pumps, is provided in the bypass pipe L41. The water removal pump P14 applies negative pressure to remove only excess water from the blood through the membrane of the blood purifier 5. That is, by controlling the operation of the water removal pump P14, the water removal process described below is performed according to a desired profile.

[0043] For the sake of convenience, some of the components and devices provided in the bypass piping L31 and the bypass piping L41 are omitted from the description of this disclosure, and various components, devices, and equipment required for blood purification are provided as appropriate. For example, depending on the specifications of the blood purification device 1a and the dialysate piping L50, other valves (solenoid valves) and the like may be provided in the bypass piping L41.

[0044] The operations of the various pumps and valves V11 to V13 described above are controlled based on control signals supplied from the information processing unit 6. In particular, in this embodiment, the operation of the water removal pump P14 is controlled based on a water removal profile set in the information processing unit 6, and a water removal speed corresponding to the water removal profile is achieved. Furthermore, these various pumps and valves V11 to V13 are capable of transmitting data indicating their operating states to the information processing unit 6. Similarly, the pressure sensors S11 and S12 are also capable of transmitting pressure values, which are measured values, to the information processing unit 6. This allows the information processing unit 6 to control the operations of the components of the internal piping unit 7 and to grasp various states of the internal piping unit 7.

[0045] As described above, the internal piping section 7 is assembled by appropriately selecting the above-mentioned parts and devices according to the piping configuration and model, and has a structure that enables the circulation and cleaning of the dialysate. The internal piping section 7 also has a structure that enables the introduction and discharge of the dialysate to and from the blood purifier 5.

[0046] [Information Processing Section] Next, the information processing unit 6 according to this embodiment is composed of a processor 6a and a memory 6b, as shown in FIG.

[0047] The processor 6a is composed of a GPU (Graphics Processing Unit) or a CPU (Central Processing Unit), and functions as a calculation unit (described later) for controlling the components of the blood purification unit 1 (particularly the blood purification device 1a) based on various processing programs stored in the memory 6b. Specifically, the processor 6a reads and executes a processing program for performing treatment to purify the patient's blood or a processing program for running the OS from the memory 6b.

[0048] The processor 6a controls the operation of various component devices, etc., from the setup to the end of blood purification therapy, performs predetermined calculations using signals received from each component device, and re-controls the operation of various component devices, etc. In particular, in this embodiment, the processor 6a performs calculation processing (described later) based on the treatment time (T), target water removal volume (Q), predetermined elapsed time (Tucr), target water removal achievement rate (UCR) at the predetermined elapsed time (Tucr), and time to reach uniform water removal rate (Ta) input via the input interface 4a, and sets a water removal profile suitable for patient H and his / her condition. More specifically, the processor 6a executes a processing program that performs setup processing for blood purification therapy for patient H. Here, the processing program receives input of the treatment time (T) of blood purification treatment, the target water removal volume (Q) in blood purification treatment, a predetermined elapsed time (Tucr) since the start of blood purification treatment, the target water removal achievement rate (UCR) at the predetermined elapsed time (Tucr), and the uniform water removal rate arrival time (Ta) required to reach the uniform water removal rate (Va) in blood purification treatment, calculates the uniform water removal rate (Va) from the treatment time (T) and the target water removal volume (Q), and multiplies the uniform water removal rate (Va) by a predetermined constant to calculate the uniform water removal rate (Va) at the predetermined elapsed time. This program calculates the predetermined time water removal rate (Vucr) during the treatment time (Tucr), divides the treatment time (T) into sections based on the predetermined elapsed time (Tucr) and the time to reach the uniform water removal rate (Ta), calculates the initial water removal rate (V0) and the final water removal rate (Ve) based on the water removal achievement rate for each section, and sets a water removal profile from the treatment time (T), the predetermined elapsed time (Tucr), the uniform water removal rate (Va), the predetermined time water removal rate (Vucr), the initial water removal rate (V0), and the final water removal rate (Ve). The details of the content and flow of this process will be described later.

[0049] The processor 6a may also continuously receive pressure values ​​from the pressure sensors S1, S11, and S12 and measure the status of the blood purification treatment initiated by the operation of the blood purification device 1a. The processor 6a may be configured with a single GPU or CPU, or may be configured with a combination of multiple CPUs or GPUs.

[0050] The memory 6b is composed of ROM, RAM, non-volatile memory, HDD, etc., and functions as a storage unit (described later). The ROM stores instructions and commands for carrying out treatment to purify the patient's blood as a processing program. The RAM is used to write and read data while the processing program stored in the ROM is being processed by the processor 6a. The non-volatile memory is a storage device into which data is written and read by the execution of the processing program, and the data written therein is retained even after the execution of the processing program has ended.

[0051] In particular, in this embodiment, the memory 6b stores a processing program for executing the calculation process described below based on the treatment time (T), target water removal volume (Q), specified elapsed time (Tucr), target water removal achievement rate (UCR) at the specified elapsed time (Tucr), and time to reach uniform water removal speed (Ta) input via the input interface 4a, and for setting a water removal profile suitable for the patient H and his / her condition.

[0052] Furthermore, memory 6b stores water removal profiles and associated setting item information for blood purification treatments previously performed by the blood purification unit 1. Specifically, a data table such as that shown in FIG. 4 is stored in memory 6b. As shown in FIG. 4, the data table stored in memory 6b contains the following items: "Unique ID," "Name," "Treatment Date and Time," "Water Removal Profile," "Treatment Time," "Target Water Removal Volume," "Specified Elapsed Time," "Target Water Removal Achievement Rate," and "Time to Reach Equal Water Removal Speed." Here, the information for the items in each row of the data table is stored in association with each other. Furthermore, "Treatment Time," "Target Water Removal Volume," "Specified Elapsed Time," "Target Water Removal Achievement Rate," and "Time to Reach Equal Water Removal Speed" are setting item information (parameters) that are set at an initial stage to determine the "water removal profile."

[0053] "Unique ID" is an identifier assigned to each patient H. "Name" is the name of patient H. "Treatment date and time" is the date and time when the previous blood purification treatment was performed. "Water removal profile" is the water removal profile set in the previous blood purification treatment, and is the graph shown in Figure 5 or Figure 6 or the numerical data of the graph. In this embodiment, the water removal profile differs depending on whether the uniform water removal rate arrival time (Ta) or the specified elapsed time (Tucr) is reached first; in the case shown in Figure 5, the uniform water removal rate arrival time (Ta) is reached first, and in the case shown in Figure 6, the specified elapsed time (Tucr) is reached first.

[0054] 5 and 6, the horizontal axis of the graph of the water removal profile is time (H) and the vertical axis is the water removal rate. In this embodiment, the water removal profile is determined by connecting the initial water removal rate (V0), the final water removal rate (Ve), the uniform water removal rate (Va), and the predetermined time water removal rate (Vucr) with straight lines. That is, to determine the water removal profile, the initial water removal rate (V0) at the start of treatment, the treatment time (T) and the final water removal rate (Ve) at the end of treatment (i.e., the treatment time (T)), the time to reach the uniform water removal rate (Ta) and the uniform water removal rate (Va) at that time, and the predetermined elapsed time (Tucr) and the predetermined time water removal rate (Vucr) at that time are required.

[0055] "Treatment time" is the period from the start of treatment to the end of treatment. The unit of treatment time is hours (H). The treatment time is divided into a first half and a second half based on T / 2, which is half of that time. In particular, in the first half of the treatment time, the burden on patient H is not large, so the water removal speed can be set high, and in the second half of the treatment, the burden on patient H due to treatment gradually accumulates, so the water removal speed is set low.

[0056] The "target volume of water removal" is the target value for the total amount of water to be removed from patient H during blood purification treatment. The unit of the target volume of water removal is liters (L). The target volume of water removal is set appropriately depending on the gender, age, weight, etc. of patient H.

[0057] The "predetermined elapsed time" is an arbitrarily set time from the start of treatment to the end of treatment, and is the time elapsed since the start of treatment. The unit of the predetermined elapsed time is hours (H), the same as the treatment time. The "target water removal achievement rate" is a numerical value indicating the extent to which water removal has been completed relative to the total amount of water removal within the predetermined elapsed time. The unit of the target water removal achievement rate is percent (%). In other words, the target water removal achievement rate is a numerical value obtained by multiplying the value obtained by dividing the amount of water removed from the start of blood purification treatment until the predetermined elapsed time (Tucr) has elapsed by the target amount of water removal.

[0058] The "uniform water removal rate arrival time" is an arbitrarily set time from the start of treatment to the end of treatment, and is the time until the water removal rate reaches the uniform water removal rate when the water removal rate decreases steadily from the start of treatment to the end of treatment. Here, the uniform water removal rate is a water removal rate that enables the removal of the target water removal volume (Q) during the treatment time (T), and is a water removal rate that is assumed to be maintained constant during the treatment time. In other words, the uniform water removal rate is the value obtained by dividing the target water removal volume (Q) by the treatment time (T).

[0059] (Setting the water removal profile) Next, with reference to Figs. 7 to 16, the configuration and method for setting a water removal profile in the blood purification unit 1 according to this embodiment will be described. Fig. 7 is a functional block diagram of the blood purification unit 1 according to this embodiment. In particular, Fig. 7 shows the electrical connections of the components constituting the blood purification unit 1. Figs. 8 and 10 are flow charts showing the process flow for setting a water removal profile in the blood purification unit 1 according to this embodiment. In particular, Fig. 8 shows various processes in the information processing unit 6. In addition, Fig. 10 shows the process for calculating the initial water removal rate (V0) and the final water removal rate (Ve) in the information processing unit 6, and shows detailed processing content of S104 in Fig. 8. Fig. 9 is an input screen for setting the water removal profile displayed in the blood purification unit 1 according to this embodiment. Figs. 11 to 16 are graphs showing an overview of the calculation process for setting a water removal profile in the blood purification unit 1 according to this embodiment. In particular, Figures 11 to 13 show the calculation process when the uniform water removal rate arrival time (Ta) arrives before the specified elapsed time (Tucr), and Figures 14 to 16 show the calculation process when the specified elapsed time (Tucr) arrives before the uniform water removal rate arrival time (Ta).

[0060] 7, in the blood purification unit 1 according to this embodiment, the information processing unit 6 includes an arithmetic unit 61 that functions when the processor 6a executes a predetermined processing program, and a storage unit 62 that functions when the memory 6b stores the processing program, processing conditions, and processing results. That is, the information processing unit 6 includes the arithmetic unit 61 that performs a predetermined process among the many processes executed by the processor 6a, and the storage unit 62 that stores a predetermined processing program, data, information, etc. among the information stored in the memory 6b. In particular, in this embodiment, the arithmetic unit 61 performs processes related to setting and executing a water removal profile.

[0061] The blood purification unit 1 according to this embodiment also has, as its functions, an input section 63 and an output section 64. Here, the input section 63 functions when the processor 6a executes a predetermined processing program to operate the input interface 4a. That is, the input section 63 functions to input various settings in advance for the blood purification unit 1. Similarly, the output section 64 functions when the processor 6a executes a predetermined processing program to operate the output interface 4b. That is, the output section 64 functions to output various settings and states for the blood purification unit 1.

[0062] 7, the calculation unit 61 includes an equal water removal rate calculation unit 61a, which is an example of a set water removal rate acquisition unit, a predetermined time water removal rate calculation unit 61b, which is an example of a predetermined time water removal rate acquisition unit, and a start / finish water removal rate calculation unit 61c, in order to execute various processes related to the water removal profile. As a result, the calculation unit 61 compiles the processing results of each unit and controls the water removal process in the blood purification therapy overall.

[0063] As shown in FIG. 7, the calculation unit 61 receives the treatment time (T), the target water removal volume (Q), the predetermined elapsed time (Tucr), the target water removal achievement rate (UCR) at the predetermined elapsed time (Tucr), and the time to reach the uniform water removal rate (Ta) from the input unit 63. Each component of the calculation unit 61 uses this information and calculation results using this information to calculate the water removal rate at each time to construct a water removal profile. Specifically, the uniform water removal rate calculation unit 61a calculates the uniform water removal rate (Va) using the treatment time (T) and the target water removal volume (Q). The predetermined time water removal rate calculation unit 61b calculates the predetermined time water removal rate (Vucr) using the uniform water removal rate (Va) and a predetermined constant. Furthermore, the initial and final water removal speed calculation unit 61c calculates the initial water removal speed (V0) and the final water removal speed (Ve) using the target water removal amount (Q), the target water removal achievement rate (UCR), the uniform water removal speed (Va), and the predetermined time water removal speed (Vucr). Details of these calculation methods will be explained together with the explanation of the processing flow related to setting the water removal profile.

[0064] The calculation unit 61 then sets a water removal profile based on the calculated water removal rate for a predetermined time (Vucr), the water removal rate for a predetermined time (Vucr), the initial water removal rate (V0), and the final water removal rate (Ve). For example, the water removal profile that is set has a gradual decrease in the water removal rate from the start to the end of blood purification treatment. Here, the gradual decrease in the water removal rate means that the water removal rate gradually decreases over time, and decreases in a downward slope over the entire treatment time.

[0065] The calculation unit 61 also stores the set water removal profile and the setting item information input from the input unit 63 in the memory unit 62. The calculation unit 61 also outputs the set water removal profile and the setting item information from the output unit 64. Furthermore, the calculation unit 61 controls the water removal pump P14 so as to correspond to the set water removal profile. Specifically, the calculation unit 61 generates a control signal for controlling the operation of the water removal pump P14 so as to realize the set water removal profile, and transmits the control signal to the water removal pump P14.

[0066] The storage unit 62 stores a processing program for executing the processing by the calculation unit 61 described above, conditions required for setting a water removal profile, and the set water removal profile. The conditions required for setting a water removal profile may include the treatment time (T), the target water removal volume (Q), a predetermined elapsed time (Tucr), the target water removal achievement rate (UCR) at the predetermined elapsed time (Tucr), and the time to reach an equal water removal rate (Ta), as well as constants used in the calculation processing described below.

[0067] As shown in FIG. 8 , in a specific flow of the method for setting a water removal profile, the calculation unit 61 determines whether or not the treatment time (T), the target water removal volume (Q), the predetermined elapsed time (Tucr), the target water removal achievement rate (UCR) at the predetermined elapsed time (Tucr), and the time to reach the uniform water removal rate (Ta) have been received (S101). Input of these setting item information is performed, for example, on an input screen 70 as shown in FIG. 9 . The input screen 70 is a screen displayed on the display 4 and includes multiple display units. Specifically, the input screen 70 displays, from top to bottom, a display unit 71 displaying basic information about the patient H, a display unit 72 for setting the treatment time (T), a display unit 73 for setting the target water removal volume (Q), a display unit 74 for setting the target water removal achievement rate (UCR) at the predetermined elapsed time (Tucr), a display unit 75 for setting the time to reach the uniform water removal rate (Ta), and a display unit 76 as a confirmation button when the settings are complete. The operator of the blood purification unit 1 can operate each display unit to input necessary information. For example, by touching each display unit, an input screen may pop up or the screen may transition to an input screen. Then, when the operator touches the decision button on the display unit 76, each setting item information is sent from the input unit 63 to the calculation unit 61 (input step). Note that each setting item information may not be input from the input unit 63 but may be read from the storage unit 62, in which case the input step becomes an acquisition step. In other words, the input step is an example of the acquisition step.

[0068] When the calculation unit 61 receives these setting item information via the input unit 63 (S101: Yes), it starts the processing from S102 onwards for setting the water removal profile. On the other hand, when the calculation unit 61 does not receive these setting item information via the input unit 63 (S101: No), it waits for input information without proceeding with the processing for setting the water removal profile.

[0069] Next, the uniform water removal rate calculation unit 61a of the calculation unit 61 calculates the uniform water removal rate (Va) for the current blood purification treatment (S102: uniform water removal rate calculation step). Specifically, the uniform water removal rate calculation unit 61a of the calculation unit 61 calculates the uniform water removal rate (Va) by dividing the received target water removal volume (Q) by the received treatment time (T). That is, the uniform water removal rate (Va) is expressed by the following mathematical formula (1). Va=Q / T (1)

[0070] Next, the predetermined time water removal rate calculation unit 61b of the calculation unit 61 calculates the predetermined time water removal rate (Vucr), which is the water removal rate at the input predetermined elapsed time (Tucr) (S103: predetermined time water removal rate calculation step). Specifically, the predetermined time water removal rate calculation unit 61b calculates the predetermined time water removal rate (Vucr) by multiplying the calculated uniform water removal rate (Va) by a preset constant. That is, the predetermined time water removal rate (Vucr) is expressed by the following mathematical formula (2). Vucr=p×Va (2) Here, the constant p may be a fixed value such as 1.5, or may be determined from the ratio of the treatment time (T) to the predetermined elapsed time (Tucr).

[0071] Next, the initial and final water removal speed calculation unit 61c of the calculation unit 61 calculates the initial water removal speed (V0) and the final water removal speed (Ve) (S104: initial and final water removal speed calculation step). Here, the initial and final water removal speed calculation step is divided into two cases as shown in Figure 10, and the initial water removal speed (V0) and the final water removal speed (Ve) are calculated by different calculation methods.

[0072] Specifically, first, the start / finish water removal rate calculation unit 61c determines whether the uniform water removal rate arrival time (Ta) arrives before the predetermined elapsed time (Tucr) (S111). Specifically, the start / finish water removal rate calculation unit 61c compares the received uniform water removal rate arrival time (Ta) with the predetermined elapsed time (Tucr), and if the value of the uniform water removal rate arrival time (Ta) is smaller than the value of the predetermined elapsed time (Tucr), it determines that the uniform water removal rate arrival time (Ta) arrives first. On the other hand, if the value of the uniform water removal rate arrival time (Ta) is greater than the value of the predetermined elapsed time (Tucr), it determines that the predetermined elapsed time (Tucr) arrives first. Then, if the uniform water removal rate arrival time (Ta) arrives first from the start of treatment, the process proceeds to S112 and subsequent steps, and if the predetermined elapsed time (Tucr) arrives first from the start of treatment, the process proceeds to S118 and subsequent steps.

[0073] If the uniform water removal rate arrival time (Ta) arrives before the predetermined elapsed time (Tucr) (S111: Yes), the start-and-finish water removal rate calculation unit 61c sets three sections in the period from the start of treatment to the end of treatment (i.e., the treatment time (T)) (S112). Specifically, as shown in the upper graph of Fig. 11, the start-and-finish water removal rate calculation unit 61c sets the first section from the start of treatment to the uniform water removal rate arrival time (Ta), the second section from the uniform water removal rate arrival time (Ta) to the predetermined elapsed time (Tucr), and the third section from the predetermined elapsed time (Tucr) to the end of treatment.

[0074] Next, the initial and final phase water removal rate calculation unit 61c calculates the second interval water removal amount (S2) (S113). Here, as shown in the lower graph of Fig. 11, the second interval water removal amount (S2) is a region surrounded by the water removal profile (shown by the dashed line), the horizontal axis, and the vertical axis, and corresponds to the area from the uniform water removal rate arrival time (Ta) to the predetermined elapsed time (Tucr). That is, since the shape of the second interval water removal amount (S2) in the lower graph of Fig. 11 is a trapezoid, the second interval water removal amount (S2) is expressed by the following mathematical formula (3). S2={(Vucr+Va)×(Tucr-Ta)} / 2 ···(3)

[0075] Therefore, the start / finish water removal rate calculation unit 61c inputs the received predetermined elapsed time (Tucr) and uniform water removal rate arrival time (Ta), and the calculated predetermined time water removal rate (Vucr) and uniform water removal rate (Va) into the formula (3). This allows the start / finish water removal rate calculation unit 61c to calculate the second section water removal amount (S2).

[0076] Next, the initial and final water removal rate calculation unit 61c calculates the first-section water removal amount (S1) (S114). Here, as shown in the upper graph of Fig. 12, the first-section water removal amount (S1) is the region surrounded by the water removal profile (shown by the dashed line), the horizontal axis, and the vertical axis, and corresponds to the area from the start of treatment to the time to reach the uniform water removal rate (Ta). Furthermore, the sum of the first-section water removal amount (S1) and the second-section water removal amount (S2) is the water removal amount up to a predetermined elapsed time (Tucr), and is therefore expressed by the following mathematical formula (4). S1 + S2 = Q × UCR (4)

[0077] Then, the formula (4) can be transformed into the following formula (5). S1 = Q × UCR - S2 (5)

[0078] Therefore, the initial and final stage water removal rate calculation unit 61c inputs the received target water removal amount (Q) and target water removal achievement rate (UCR), and the calculated second section water removal amount (S2) into formula (5). This allows the initial and final stage water removal rate calculation unit 61c to calculate the first section water removal amount (S1).

[0079] Next, the initial / final water removal rate calculation unit 61c calculates the initial water removal rate (V0) (S115). Here, as shown in the lower graph of Fig. 12, the first-section water removal rate (S1) is the region surrounded by the water removal profile (shown by the dashed line), the horizontal axis, and the vertical axis, and corresponds to the area from the start of treatment to the time to reach the uniform water removal rate (Ta). That is, since the shape of the first-section water removal rate (S1) in the lower graph of Fig. 11 is a trapezoid, the first-section water removal rate (S1) is expressed by the following mathematical formula (6). S1={(Va+V0)×Ta} / 2 (6)

[0080] Then, the formula (6) can be transformed into the following formula (7). V0=S1×(2 / Ta)-Va (7)

[0081] Therefore, the initial and final stage water removal rate calculation unit 61c inputs the received uniform water removal rate arrival time (Ta), the calculated first section water removal amount (S1), and the uniform water removal rate (Va) into the formula (7). As a result, the initial and final stage water removal rate calculation unit 61c can calculate the initial stage water removal rate (V0).

[0082] Next, the initial and final water removal rate calculation unit 61c calculates the third-section water removal amount (S3) (S116). Here, as shown in the upper graph of Fig. 13, the third-section water removal amount (S3) is the region surrounded by the water removal profile (shown by the dashed line), the horizontal axis, and the vertical axis, and corresponds to the area from the predetermined elapsed time (Tucr) to the end of treatment. The sum of the first-section water removal amount (S1), the second-section water removal amount (S2), and the third-section water removal amount (S3) is the target water removal amount (Q), which is the water removal amount up to the treatment time (T), and is expressed by the following formula (8). S1+S2+S3=Q (8)

[0083] Then, the formula (8) can be transformed into the following formula (9). S3=Q-(S1+S2) (9)

[0084] Therefore, the start / finish water removal rate calculation unit 61c inputs the calculated first interval water removal amount (S1) and second interval water removal amount (S2) into the formula (9), thereby allowing the start / finish water removal rate calculation unit 61c to calculate the third interval water removal amount (S3).

[0085] Next, the initial and final water removal rate calculation unit 61c calculates the final water removal rate (Ve) (S117). Here, as shown in the lower graph of Fig. 13, the third-section water removal rate (S3) is the region surrounded by the water removal profile (shown by the dashed line), the horizontal axis, and the vertical axis, and corresponds to the area from the predetermined elapsed time (Tucr) to the end of treatment. That is, since the shape of the third-section water removal rate (S3) in the lower graph of Fig. 13 is a trapezoid, the third-section water removal rate (S3) is expressed by the following formula (10). S3={(Ve+Vucr)×(T-Tucr)} / 2 ···(10)

[0086] Then, the formula (10) can be transformed into the following formula (11). Ve=S3×2 / (T-Tucr)-Vucr (11)

[0087] Therefore, the initial and final water removal rate calculation unit 61c inputs the received treatment time (T) and the predetermined elapsed time (Tucr), as well as the calculated predetermined time water removal rate (Vucr) and the third section water removal volume (S3) into the formula (11). This allows the initial and final water removal rate calculation unit 61c to calculate the final water removal rate (Ve).

[0088] On the other hand, if the predetermined elapsed time (Tucr) arrives before the uniform water removal rate arrival time (Ta) (S111: No), the start-and-finish water removal rate calculation unit 61c sets three intervals in the period from the start of treatment to the end of treatment (i.e., the treatment time (T)) (S118). Specifically, as shown in the upper graph of Fig. 14, the start-and-finish water removal rate calculation unit 61c sets the first interval from the start of treatment to the predetermined elapsed time (Tucr), the second interval from the predetermined elapsed time (Tucr) to the uniform water removal rate arrival time (Ta), and the third interval from the uniform water removal rate arrival time (Ta) to the end of treatment.

[0089] Next, the initial and final phase water removal rate calculation unit 61c calculates the first-section water removal amount (S1) (S119). Here, as shown in the lower graph of Fig. 14, the first-section water removal amount (S1) is the region surrounded by the water removal profile (shown by the dashed line), the horizontal axis, and the vertical axis, and corresponds to the area from the start of treatment to a predetermined elapsed time (Tucr). On the other hand, the first-section water removal amount (S1) is the amount of water removed up to the predetermined elapsed time (Tucr), and is therefore expressed by the following mathematical formula (12). S1 = Q × UCR (12)

[0090] Therefore, the initial and final stage water removal rate calculation unit 61c inputs the received target water removal amount (Q) and target water removal achievement rate (UCR) into the formula (12). As a result, the initial and final stage water removal rate calculation unit 61c can calculate the first section water removal amount (S1).

[0091] Next, the initial / final water removal rate calculation unit 61c calculates the initial water removal rate (V0) (S120). Here, as shown in the upper graph of Fig. 15, the first-section water removal rate (S1) is the region surrounded by the water removal profile (shown by the dashed line), the horizontal axis, and the vertical axis, and corresponds to the area from the start of treatment to a predetermined elapsed time (Tucr). That is, since the shape of the first-section water removal rate (S1) in the lower graph of Fig. 15 is a trapezoid, the first-section water removal rate (S1) is expressed by the following mathematical formula (13). S1={(Vucr+V0)×Tucr} / 2 ···(13)

[0092] Then, the formula (13) can be transformed into the following formula (14). V0=S1×(2 / Tucr)-Vucr (14)

[0093] Therefore, the initial and final stage water removal rate calculation unit 61c inputs the received uniform water removal rate arrival time (Tucr), the calculated first section water removal amount (S1), and the uniform water removal rate (Vucr) into the formula (14). As a result, the initial and final stage water removal rate calculation unit 61c can calculate the initial stage water removal rate (V0).

[0094] Next, the initial and final phase water removal rate calculation unit 61c calculates the second interval water removal amount (S2) (S121). Here, as shown in the lower graph of Fig. 15, the second interval water removal amount (S2) is a region surrounded by the water removal profile (shown by the dashed line), the horizontal axis, and the vertical axis, and corresponds to the area from the predetermined elapsed time (Tucr) to the time to reach the uniform water removal rate (Ta). That is, since the shape of the second interval water removal amount (S2) in the lower graph of Fig. 15 is a trapezoid, the second interval water removal amount (S2) is expressed by the following mathematical formula (15). S2={(Va+Vucr)×(Ta-Tcur)} / 2 ···(15)

[0095] Therefore, the start / finish water removal rate calculation unit 61c inputs the received predetermined elapsed time (Tucr) and uniform water removal rate arrival time (Ta), and the calculated predetermined time water removal rate (Vucr) and uniform water removal rate (Va) into the formula (15). This allows the start / finish water removal rate calculation unit 61c to calculate the second section water removal amount (S2).

[0096] Next, the initial and final phase water removal rate calculation unit 61c calculates the third-section water removal amount (S3) (S122). Here, as shown in the upper graph of FIG. 16, the third-section water removal amount (S3) is the region surrounded by the water removal profile (shown by the dashed line), the horizontal axis, and the vertical axis, and corresponds to the area from the uniform water removal rate arrival time (Ta) to the end of treatment. The third-section water removal amount (S3) is expressed by the above-mentioned formula (9). Therefore, the initial and final phase water removal rate calculation unit 61c inputs the calculated first-section water removal amount (S1) and second-section water removal amount (S2) into formula (9). This allows the initial and final phase water removal rate calculation unit 61c to calculate the third-section water removal amount (S3).

[0097] Next, the initial and final water removal rate calculation unit 61c calculates the final water removal rate (Ve) (S123). Here, as shown in the lower graph of Fig. 16, the third-section water removal rate (S3) is the region surrounded by the water removal profile (shown by the dashed line), the horizontal axis, and the vertical axis, and corresponds to the area from the time to reach the uniform water removal rate (Ta) to the end of treatment. That is, since the shape of the third-section water removal rate (S3) in the lower graph of Fig. 16 is a trapezoid, the third-section water removal rate (S3) is expressed by the following mathematical formula (16). S3={(Ve+Va)×(T-Ta)} / 2 ···(16)

[0098] Then, the formula (16) can be transformed into the following formula (17). Ve = S3 × 2 / (T - Ta) - Va (17)

[0099] Therefore, the initial and final water removal rate calculation unit 61c inputs the received treatment time (T) and uniform water removal rate arrival time (Ta), as well as the calculated uniform water removal rate (Va) and the third section water removal amount (S3) into the formula (17). As a result, the initial and final water removal rate calculation unit 61c can calculate the final water removal rate (Ve).

[0100] 8, the calculation unit 61 sets a water removal profile based on the received treatment time (T), predetermined elapsed time (Tucr), and uniform water removal rate arrival time (Ta), as well as the calculated uniform water removal rate (Va), uniform water removal rate (Vucr), initial water removal rate (V0), and final water removal rate (Ve) (S105: setting step). Specifically, the calculation unit 61 uses the above information to set a water removal profile in which the water removal rate gradually decreases from the start to the end of blood purification treatment.

[0101] For example, the calculation unit 61 sets a water removal profile that slopes downward to the right, with the slope changing in three stages from the start of treatment to the end of treatment, as shown in Figure 5 or Figure 6. As described above, the water removal profile is divided into two types shown in Figure 5 and Figure 6, depending on whether the predetermined elapsed time (Tucr) or the time to reach the uniform water removal speed (Ta) is reached first.

[0102] Next, the calculation unit 61 outputs and stores the set water removal profile (S106). Specifically, the calculation unit 61 outputs the set water removal profile from the output unit 64. That is, the water removal profile is displayed on the display 4, allowing the operator of the blood purification unit 1 to visually confirm it. Here, in addition to the water removal profile including each calculated water removal rate, the calculation unit 61 may also display the received setting item information, such as the treatment time (T), target water removal volume (Q), predetermined elapsed time (Tucr), target water removal achievement rate (UCR) at the predetermined elapsed time (Tucr), and time to reach the uniform water removal rate (Ta). This allows the operator to confirm each water removal rate and modify the setting item information in whole or in part, thereby enabling a more optimal water removal profile to be reset. The calculation unit 61 also stores the set water removal profile in the memory unit 62. This allows the calculation unit 61 to read and reset a previously set water removal profile, and may even allow a new water removal profile to be set using a previously set water removal profile.

[0103] Next, the calculation unit 61 determines whether or not treatment is to be initiated in the blood purification unit 1 (S107). For example, when the operator of the blood purification unit 1 presses the treatment start button displayed on the display 4, the calculation unit 61 receives an instruction to start blood purification treatment and determines that the blood purification unit 1 is in a treatment start state (S107: Yes). On the other hand, if the treatment start button is not pressed and an instruction to start blood purification treatment is not received, the calculation unit 61 enters a state of waiting for an instruction to start treatment (S107: No).

[0104] Next, when the blood purification unit 1 enters a treatment start state, the calculation unit 61 executes control to start blood purification treatment. In particular, in this embodiment, the calculation unit 61 controls the water removal pump P14 based on the set water removal profile (S108). Specifically, the calculation unit 61 generates and supplies a control signal for controlling the rotation speed of the water removal pump P14, driving the water removal pump P14 at the desired rotation speed. This achieves the water removal profile shown in FIG. 5 or 6, and blood purification treatment, including the water removal process, for patient H proceeds.

[0105] (Operation and effect of the first embodiment) In this embodiment, the water removal rate is calculated based on the setting item information of the treatment time (T), the target water removal volume (Q), the predetermined elapsed time (Tucr), the target water removal achievement rate (UCR) at the predetermined elapsed time (Tucr), and the time to reach the uniform water removal rate (Ta), and the water removal profile is automatically set based on the calculation results. Therefore, the water removal profile is automatically set by the operator of the blood purification unit 1 simply by inputting items, thereby reducing the burden on the operator and the number of work steps. In particular, because the target water removal achievement rate (UCR) and the time to reach the uniform water removal rate (Ta) are directly input by the operator, an intuitive water removal profile is set.

[0106] Furthermore, in this embodiment, the period from the start of treatment to the end of treatment is divided into multiple sections based on the input setting item information, and the water removal rate and the rate of decrease in the water removal rate are set for each section. Therefore, compared to conventional water removal profiles, it is possible to improve the blood pressure stability of patient H and optimize water removal efficiency.

[0107] As described above, this embodiment simplifies the process of setting the water removal profile, while enabling a water removal process that can accommodate a variety of patients and reduces the burden on the patient.

[0108] (Modification of the first embodiment) In the above embodiment, it was assumed that one predetermined elapsed time (Tucr) and one target water removal rate (Q) at that time were set, but two or more may be set. An example of a water removal profile set in such a case is shown in Fig. 17 and Fig. 18. Fig. 17 and Fig. 18 are graphs showing modified water removal profiles of the blood purification unit 1 according to this embodiment. In particular, in Fig. 17 and Fig. 18, the horizontal axis represents time and the vertical axis represents the water removal rate.

[0109] 17 is set, a first predetermined elapsed time (Tucr1) that is reached before the uniform water removal rate arrival time (Ta) and the first target water removal rate (Q1) at that time, and a second predetermined elapsed time (Tucr2) and the second target water removal rate (Q2) at that time are input as the predetermined elapsed time and the target water removal rate from the input unit 63. For this reason, the calculation unit 61 divides the period from the start to the end of treatment into four sections and sets the sections. Specifically, a first section from the start of treatment to the first predetermined elapsed time (Tucr1), a second section from the first predetermined elapsed time (Tucr1) to the second predetermined elapsed time (Tucr2), a third section from the second predetermined elapsed time (Tucr2) to the uniform water removal rate arrival time (Ta), and a fourth section from the uniform water removal rate arrival time (Ta) to the end of treatment are set.

[0110] Furthermore, the predetermined time water removal rate calculation unit 61b calculates the water removal rates (first water removal rate Vucr1, second water removal rate Vucr2) at the first predetermined elapsed time (Tucr1) and the second predetermined elapsed time (Tucr2). This calculation method is performed in the same manner as in the embodiment described above. Furthermore, the start and end water removal rate calculation unit 61c calculates the start water removal rate (V0) based on the amount of water removed in the first section from the start of treatment to the first predetermined elapsed time (Tucr1), and calculates the end water removal rate (Ve) based on the amount of water removed in the fourth section from the time to reach the uniform water removal rate (Ta) to the end of treatment. This calculation method is performed in the same manner as in the embodiment described above.

[0111] As a result, the calculation unit 61 sets a water removal profile in which the water removal speed gradually decreases, with a downward slope, as shown in Fig. 17. In particular, in Fig. 17, four straight lines with different slopes are set in each section from the start of treatment to the end of treatment, and the water removal profile is formed by these four straight lines.

[0112] On the other hand, when the water removal profile shown in Fig. 18 is set, a first predetermined elapsed time (Tucr1') that is reached before the uniform water removal rate arrival time (Ta) and the first target water removal rate (Q1') at that time, and a second predetermined elapsed time (Tucr2') that is reached after the uniform water removal rate arrival time (Ta) and the second target water removal rate (Q2') at that time are input from the input unit 63 as the predetermined elapsed time and the target water removal rate. As in the case of Fig. 17, the calculation unit 61 divides the period from the start to the end of treatment into four sections and sets the sections. Specifically, a first section from the start of treatment to the first predetermined elapsed time (Tucr1'), a second section from the first predetermined elapsed time (Tucr1') to the uniform water removal rate arrival time (Ta), a third section from the uniform water removal rate arrival time (Ta) to the second predetermined elapsed time (Tucr2'), and a fourth section from the second predetermined elapsed time (Tucr2') to the end of treatment are set.

[0113] Furthermore, the predetermined time water removal rate calculation unit 61b calculates the water removal rates (first water removal rate Vucr1', second water removal rate Vucr2') at a first predetermined elapsed time (Tucr1') and a second predetermined elapsed time (Tucr2'). This calculation method is performed in the same manner as in the embodiment described above. Furthermore, the start-end water removal rate calculation unit 61c calculates the start-end water removal rate (V0) based on the amount of water removed in the first section from the start of treatment to the first predetermined elapsed time (Tucr1'), and calculates the end-end water removal rate (Ve) based on the amount of water removed in the fourth section from the time to reach the uniform water removal rate (Ta) to the end of treatment. This calculation method is performed in the same manner as in the embodiment described above.

[0114] As a result, the calculation unit 61 sets a water removal profile in which the water removal speed gradually decreases, as shown in Fig. 18. In particular, in Fig. 18 as well, four straight lines with different slopes are set in each section from the start of treatment to the end of treatment, and the water removal profile is formed by these four straight lines.

[0115] As described above, even if the number of set predetermined elapsed times and their target water removal rates increases to two or more, the water removal profile is finally set by sequentially setting the sections and calculating each water removal rate. As the set predetermined elapsed times and their target water removal rates increase, the number of water removal rate settings within the treatment time increases, making it possible to set a more precise water removal profile.

[0116] In the above-described embodiment, it is assumed that the predetermined elapsed time (Tucr) is input. However, the predetermined elapsed time (Tucr) may be preset by the operator and stored in the memory unit 62. In such a case, the predetermined elapsed time (Tucr) may be read from the memory unit 62, and the target water removal achievement rate (UCR) may be input each time by the operator. Furthermore, not only the predetermined elapsed time (Tucr), but also the treatment time (T), the target water removal volume (Q), the target water removal achievement rate (UCR) at the predetermined elapsed time (Tucr), and the time to reach the uniform water removal rate (Ta) may be preset by the operator and stored in the memory unit 62. In such a case, input of setting item information from the input unit 63 is not necessary, but the calculation unit 61 reads and acquires this setting item information from the memory unit 62. In other words, the calculation unit may function as an acquisition unit for setting item information.

[0117] In the above-described embodiment, the uniform water removal rate arrival time (Ta) was input to calculate the uniform water removal rate (Va). However, instead of the uniform water removal rate (Va), a set water removal rate set by the operator may be calculated or read from the memory unit 62. In this case, instead of the uniform water removal rate arrival time (Ta), the set water removal rate arrival time may be input or read from the memory unit 62. In other words, the set water removal rate and the set water removal rate arrival time may be acquired. Therefore, the uniform water removal rate arrival time (Ta) is an example of the set water removal rate arrival time, and the uniform water removal rate (Va) is also an example of the set water removal rate. Furthermore, a set water removal rate acquisition unit functions instead of the uniform water removal rate calculation unit 61a. Therefore, the uniform water removal rate calculation unit 61a is an example of a set water removal rate acquisition unit. In such a case, the predetermined time water removal rate may not be calculated but may be read from the memory unit 62. That is, the predetermined time water removal speed acquisition unit functions in place of the predetermined time water removal speed calculation unit 61b. Therefore, the predetermined time water removal speed calculation unit 61b is an example of the predetermined time water removal speed acquisition unit.

[0118] In addition, the set water removal rate arrival time (including the uniform water removal rate arrival time) may be equal to the predetermined elapsed time (Tucr). In this case, the treatment time (T) is divided into two sections instead of three. Even in such a case, the water removal profile is finally set by sequentially setting the sections and calculating each water removal rate. By reducing the set predetermined elapsed time and its target water removal rate, the number of water removal rate settings within the treatment time also decreases, making it possible to reduce the burden and time required for setting the water removal profile.

[0119] In the above-described embodiment, the initial water removal rate (V0) is the water removal rate at the start of treatment, and the final water removal rate (Ve) is the water removal rate at the end of treatment, but this is not limited to this. That is, the initial water removal rate (V0) may be calculated as the water removal rate at a predetermined time after the start of treatment (e.g., 10 minutes after the start of treatment), and the final water removal rate (Ve) may be calculated as the water removal rate at a time point before a predetermined time after the end of treatment (e.g., 10 minutes before the end of treatment). In other words, a water removal profile within a certain period from the start of treatment to the end of treatment may be set based on the above-described processing flow. In such a case, the water removal rate at the start of treatment and the water removal rate at the end of treatment may be set separately in advance or may even be calculated separately.

[0120] Second Embodiment In the first embodiment, when the blood purification unit 1 sets a water removal profile, calculations are performed based on newly entered setting item information. However, previous setting item information may be displayed and the operator may select from the displayed information. This configuration will be described as the second embodiment with reference to FIGS. 19 to 22. FIG. 19 is a flow chart showing the process flow for setting a water removal profile in the blood purification unit according to this embodiment. FIGS. 20 to 22 are input screens for setting water removal profile items displayed in the blood purification unit according to this embodiment. Note that the basic configuration of this embodiment is the same as that of the first embodiment, but the process for setting the water removal profile is different. Therefore, the differences will be basically described, and the same content will not be described again, and the same reference numerals will be used in the drawings.

[0121] 19, in the processing flow of this embodiment, first, the calculation unit 61 determines whether or not the treatment time (T), the target water removal volume (Q), the predetermined elapsed time (Tucr), the target water removal achievement rate (UCR) at the predetermined elapsed time (Tucr), and the time to reach the uniform water removal speed (Ta) have been received (S201). S201 is the same as S101 in the first embodiment, and therefore a detailed description thereof will be omitted.

[0122] When the calculation unit 61 receives the setting item information via the input unit 63 (S201: Yes), it performs a calculation process for setting a water removal profile, a setting process for the water removal profile, and a control process (S202). Since S202 is the same as the process from S102 onwards in the first embodiment, a detailed description thereof will be omitted.

[0123] On the other hand, if the calculation unit 61 does not receive this setting item information (S201: No), it determines whether or not there is an instruction to read out past setting item information (S203). For example, as shown in FIG. 20, the input screen 70 is provided with a display unit 77 that is a button for reading out past setting item information. When the operator of the blood purification unit 1 touches the display unit 77, an instruction to read out past setting item information is transmitted from the input unit 63 to the calculation unit 61. Therefore, the calculation unit 61 determines whether or not there is an instruction to read out past setting item information in response to the operator's touch operation on the display unit 77.

[0124] If there is no instruction to read out past setting item information (S203: Yes), the calculation unit 61 determines whether or not there is a decision instruction (S204). For example, as shown in FIG. 20, the input screen 70 is provided with a display unit 76 that is a decision button. When the operator of the blood purification unit 1 touches the display unit 76, an instruction to start calculation based on the setting item information of the water removal profile is transmitted from the input unit 63 to the calculation unit 61. Therefore, the calculation unit 61 determines whether or not there is a decision instruction in response to the operator's touch operation on the display unit 76.

[0125] If there is no decision instruction (S204: No), the process returns to S201, and the calculation unit 61 determines again whether or not it has received setting item information via the input unit 63. On the other hand, if there is a decision instruction (S204: Yes) or if there is an instruction to read out past setting item information (S203: No), the calculation unit 61 determines whether or not past setting item information is stored in the storage unit 62 (S205). Specifically, the calculation unit 61 checks the data table shown in Fig. 4 and reads out the past treatment results of the current patient H.

[0126] If the past setting item information is stored in the storage unit 62 (S205: Yes), the calculation unit 61 displays the past setting item information from the output unit 64 (S206). For example, as shown in FIG. 21 , an additional display unit 72a displaying the past setting item information is displayed as a pop-up on the side of the display unit 72. The additional display unit 72a displays the past setting item information in a selectable manner, and the operator can select it by touching it. Note that additional display units may also be displayed on the side of other display units at the same time, or when predetermined information is selected from the additional display unit 72a, the additional display unit of the next display unit may be displayed. Then, after the past setting item information is displayed on the output unit 64, the process returns to S201, and the calculation unit 61 again determines whether or not setting item information has been received via the input unit 63.

[0127] On the other hand, if past setting item information is not stored in the storage unit 62 (S205: No), the calculation unit 61 displays a warning from the output unit 64 that setting item information has not been input (S207). For example, as shown in FIG. 22, the colors of the display units 72 to 75 corresponding to the items that have not been input are changed so that the operator can understand that the information has not been input. Note that, as shown in FIG. 21, a warning message that the information has not been input may be displayed as a pop-up as an additional display unit. Then, after the warning that the information has not been input is displayed from the output unit 64, the process returns to S201, and the calculation unit 61 again determines whether setting item information has been received via the input unit 63.

[0128] (Operation and effect of the second embodiment) As described above, this embodiment can also achieve the same effects as the first embodiment. Furthermore, in this embodiment, past setting item information is displayed in a selectable manner, which can assist the operator of the blood purification unit 1 in inputting information. Furthermore, since setting item information that has not been input can be visually confirmed, forgetting to input information can be prevented.

[0129] <Third embodiment> In the second embodiment, if past setting item information is stored, the past setting item information is displayed in a predetermined state and the operator can select it. However, if past setting item information is not stored, other information may be displayed instead of the past setting item information. This embodiment will be described as a third embodiment with reference to FIGS. 23 and 24. FIG. 23 is a flow chart showing the process flow for setting a water removal profile in a blood purification unit according to this embodiment. FIG. 24 is an input screen for setting water removal profile items displayed in a blood purification unit according to this embodiment. The basic configuration of this embodiment is the same as that of the first and second embodiments, but some of the process for setting the water removal profile is different. Therefore, the differences will be described in principle, and explanations of the same content will be omitted, and the same reference numerals will be used in the drawings. In particular, steps S301 to S305 in FIG. 23 are the same as steps S201 to S205 in the second embodiment, and therefore explanations thereof will be omitted.

[0130] 23, if past setting item information is stored in the storage unit 62 (S305: Yes), the calculation unit 61 displays a warning from the output unit 64 that the setting item information has not been input (S306). As in FIG. 22 of the second embodiment, the warning is displayed by changing the color of the display units 72 to 75 corresponding to the items that have not been input, so that the operator can understand that the information has not been input. After the warning that the information has not been input is displayed from the output unit 64, the process returns to S301, and the calculation unit 61 again determines whether the setting item information has been received via the input unit 63.

[0131] On the other hand, if the past setting item information is not stored in the storage unit 62 (S305: No), the calculation unit 61 displays the setting item information for diversion settings from the output unit 64 (S307). The setting item information for diversion settings is stored in the storage unit 62 and can be read and additionally written by the calculation unit 61. Here, the setting item information for diversion settings may be general setting item information that is set for patients similar to patient H (patients with similar gender, weight, and medical condition). In addition, the setting item information for diversion settings may be setting item information for other patients similar to patient H.

[0132] For example, as shown in FIG. 24, an additional display section 72b that displays setting item information for diversion settings is displayed as a pop-up on the side of the display section 72. The setting item information for diversion settings is displayed selectably on the additional display section 72b, and can be selected by the operator by touching it. Note that additional display sections may also be displayed simultaneously on the side of other display sections, or when predetermined information is selected from the additional display section 72b, the additional display section of the next display section may be displayed. Then, after the setting item information for diversion settings is displayed from the output section 64, the process returns to S301, and the calculation section 61 again determines whether setting item information has been received via the input section 63.

[0133] (Operation and effect of the third embodiment) As described above, this embodiment can also achieve the same effects as the first embodiment. Furthermore, in this embodiment, the setting item information for diversion setting is displayed in a selectable manner, which can assist the operator of the blood purification unit 1 in inputting information. Furthermore, since unentered setting item information can be visually confirmed, forgetting to enter information can be prevented.

[0134] <Fourth embodiment> In the first embodiment, the blood purification unit 1 had a calculation unit 61 that performs processing to set the water removal profile and a memory unit 62 that stores the processing program and setting information required for the setting. However, an information processing device communicably connected to the blood purification unit 1 may have functions in place of the calculation unit 61 and the memory unit 62. This embodiment will be described as the fourth embodiment with reference to FIGS. 25 and 26. FIG. 25 is a schematic diagram showing the mechanical configuration of the blood purification system according to this embodiment. FIG. 26 is a functional block diagram of the blood purification system according to this embodiment. In this embodiment, differences from the first embodiment will be basically described, and descriptions of the same contents will be omitted, and the same reference numerals will be used in the drawings.

[0135] 25 and 26, the blood purification system 300 according to this embodiment is made up of a blood purification unit 101 that performs blood purification treatment on patient H, and a terminal device 201, which is an information processing device that is communicatively connected to the blood purification unit 101. The blood purification unit 101 and terminal device 201 may be installed in the same building, i.e., a hospital, but the terminal device 201 may also be installed in a different building, or may be installed as a server device on the cloud.

[0136] As shown in FIGS. 25 and 26 , the blood purification unit 101 has the same basic configuration for blood purification therapy as the blood purification unit 1 of the first embodiment. Unlike the blood purification unit 1 of the first embodiment, the blood purification unit 101 does not have functions for calculating and setting the water removal profile. That is, although the information processing unit 106 of the blood purification unit 101 includes a calculation unit 161 and a memory unit 162, the calculation unit 161 and the memory unit 162 execute various processes related to blood purification therapy other than the processes related to the water removal profile. Therefore, the setting item information related to the water removal profile settings, i.e., the treatment time (T), target water removal volume (Q), predetermined elapsed time (Tucr), target water removal achievement rate (UCR), and uniform water removal rate arrival time (Ta), input from the input unit 63, is not processed by the calculation unit 161 or the memory unit 162 but is transmitted from the calculation unit 161 to the terminal device 201 via the communication unit 165.

[0137] 26, the terminal device 201 has a calculation unit 261, a storage unit 262, and a communication unit 265. The calculation unit 261 has the same configuration as the calculation unit 61 of the first embodiment and performs the same processing. The storage unit 262 has the same configuration as the storage unit 62 of the first embodiment and performs the same processing. Therefore, the terminal device 201 performs various processes related to setting the water removal profile in the blood purification unit 101, in place of the blood purification unit 101. The processing performed by the calculation unit 261 may be processing that uses past setting item information, etc., described in the second or third embodiment.

[0138] Furthermore, the water removal profile calculated in the terminal device 201 is transmitted to the blood purification unit 101 via the communication unit 265. In the blood purification unit 101, the calculation unit 161 transmits the received water removal profile to the output unit 64, and the water removal profile is displayed so that it can be visually confirmed by the operator of the blood purification unit 101. The calculation unit 161 also controls the water removal pump P14 in accordance with the water removal profile.

[0139] (Operation and effect of the fourth embodiment) As described above, this embodiment can also achieve the same effects as the first embodiment. Furthermore, in this embodiment, the part that sets the water removal profile is separated from the blood purification unit 101, which reduces the processing load on the blood purification unit 101 and further reduces the cost of the blood purification unit 101. Furthermore, multiple water removal profiles can be managed collectively, which makes it easier to set, manage, and operate the water removal profiles.

[0140] <Embodiments of the present disclosure> A first embodiment of the present disclosure is a blood purification device that performs blood purification treatment on a patient, and has a calculation unit that sets a water removal profile based on the treatment time of the blood purification treatment, the target water removal amount in the blood purification treatment, the target water removal achievement rate in a specified elapsed time after the start of the blood purification treatment, and the set water removal rate arrival time until the set water removal rate in the blood purification treatment is reached, and the calculation unit is equipped with a set water removal rate acquisition unit that acquires the set water removal rate, a specified time water removal rate acquisition unit that acquires the specified time water removal rate in the specified elapsed time, and an initial and final water removal rate calculation unit that divides the treatment time into sections based on the specified elapsed time and the set water removal rate arrival time, and calculates the initial water removal rate and final water removal rate based on the section-specific water removal rate for each section.

[0141] In this way, the water removal rate is calculated based on the setting item information of the treatment time, the target water removal volume, the predetermined elapsed time, the target water removal achievement rate at the predetermined elapsed time, and the set water removal rate arrival time, and the water removal profile is automatically set based on the calculation results. Therefore, the water removal profile is automatically set by the operator simply setting items, thereby reducing the burden on the operator and the work hours. In particular, when the target water removal achievement rate and the set water removal rate arrival time are directly input by the operator, an intuitive water removal profile is set. Furthermore, the period from the start to the end of treatment is divided into multiple sections, and the water removal rate and the water removal rate reduction rate are set for each section. Therefore, compared to conventional water removal profiles, the patient's blood pressure stability can be improved and the water removal efficiency can be optimized. For these reasons, this embodiment simplifies the water removal profile setting process while enabling a water removal process that can be adapted to various patients and reduces the burden on the patient.

[0142] A second embodiment of the present disclosure is the first embodiment, wherein the set water removal rate is a uniform water removal rate, the set water removal rate arrival time is a uniform water removal rate arrival time required to reach the uniform water removal rate, and the calculation unit includes an uniform water removal rate calculation unit that calculates the uniform water removal rate from the treatment time and the target water removal rate, and a predetermined time water removal rate calculation unit that calculates the predetermined time water removal rate at the predetermined elapsed time by multiplying the uniform water removal rate by a predetermined constant. In this way, the water removal rate is calculated based on the setting item information of the treatment time, the target water removal rate, the predetermined elapsed time, the target water removal achievement rate at the predetermined elapsed time, and the uniform water removal rate arrival time, and the water removal profile is automatically set based on the calculation result. Therefore, the water removal profile is automatically set by simply setting the items, thereby reducing the burden on the operator and reducing the work hours. In particular, when the target water removal achievement rate and the uniform water removal rate arrival time are directly input by the operator, an intuitive water removal profile is set.

[0143] In a third embodiment of the present disclosure, in the second embodiment, when the uniform water removal rate arrival time is reached before the predetermined elapsed time, the start / end water removal rate calculation unit calculates a first section water removal amount from the start of treatment to the uniform water removal rate arrival time, a second section water removal amount from the uniform water removal rate arrival time to the predetermined elapsed time, and a third section water removal amount from the predetermined elapsed time to the end of treatment. This allows the water removal rate to be controlled in stages in the three sections, allowing the water removal profile to be set with higher accuracy, enabling water removal control that can respond to the patient and each patient's condition and performs efficient water removal treatment while reducing the burden on the patient.

[0144] A fourth embodiment of the present disclosure is the third embodiment, wherein the initial and final water removal rate calculation unit calculates the second interval water removal amount from the uniform water removal rate arrival time, the uniform water removal rate, the predetermined elapsed time, and the predetermined time water removal rate, calculates the first interval water removal amount from the target water removal amount, the target water removal achievement rate, and the second interval water removal amount, calculates the initial water removal rate from the first interval water removal amount, the uniform water removal rate arrival time, and the uniform water removal rate, calculates the third interval water removal amount from the target water removal amount, the first interval water removal amount, and the second interval water removal amount, and calculates the final water removal rate based on the third interval water removal amount, the treatment time, the predetermined elapsed time, and the predetermined time water removal rate. This makes it possible to easily calculate and uniquely determine each water removal rate, improving the accuracy of setting the water removal profile.

[0145] In a fifth embodiment of the present disclosure, in the second embodiment, when the uniform water removal rate arrival time arrives after the predetermined elapsed time, the start / end water removal rate calculation unit calculates a first section water removal amount from the start of treatment to the predetermined elapsed time, a second section water removal amount from the predetermined elapsed time to the uniform water removal rate arrival time, and a third section water removal amount from the uniform water removal rate arrival time to the end of treatment. This allows the water removal rate to be controlled in stages in the three sections, so that the water removal profile can be set with higher accuracy, can respond to the patient and each patient's condition, and enables water removal control for efficient water removal treatment while reducing the burden on the patient.

[0146] A sixth embodiment of the present disclosure is the fifth embodiment, wherein the initial and final water removal rate calculation unit calculates the first interval water removal rate from the target water removal rate and the target water removal achievement rate, calculates the initial water removal rate from the first interval water removal rate, the uniform water removal rate arrival time, and the uniform water removal rate, calculates the second interval water removal rate from the uniform water removal rate arrival time, the uniform water removal rate, the specified elapsed time, and the specified time water removal rate, calculates the third interval water removal rate from the target water removal rate, the first interval water removal rate, and the second interval water removal rate, and calculates the final water removal rate based on the third interval water removal rate, the treatment time, the specified elapsed time, and the specified time water removal rate. This makes it possible to easily calculate and uniquely determine each water removal rate, improving the accuracy of setting the water removal profile.

[0147] A seventh embodiment of the present disclosure is the second embodiment, further comprising an input unit for inputting the treatment time, the target water removal volume, the target water removal achievement rate, and the time to reach the uniform water removal rate. This allows various calculations to be performed based on two pieces of information directly input by the operator, making it possible to intuitively set a water removal profile.

[0148] An eighth embodiment of the present disclosure is the seventh embodiment, further comprising a storage unit for storing past water removal profiles and an output unit for outputting the past water removal profiles, and when setting item information related to the past water removal profiles is selected via the input unit, the calculation unit sets the water removal profile based on the setting item information. This further reduces the burden on the operator and the number of work steps. Furthermore, using past setting item information can also reduce input errors.

[0149] A ninth embodiment of the present disclosure is the eighth embodiment, wherein the calculation unit, when any of the treatment time, the target water removal volume, the predetermined elapsed time, the target water removal achievement rate, and the time to reach the uniform water removal speed is not input via the input unit, causes the output unit to selectably display setting item information related to the past water removal profile. This further reduces the burden on the operator and the number of work steps. Furthermore, using past setting item information can also reduce input errors.

[0150] In a tenth embodiment of the present disclosure, in the eighth embodiment, when the treatment time, the target water removal volume, the predetermined elapsed time, the target water removal achievement rate, and the uniform water removal speed arrival time were input via the input unit during the setting of the previous water removal profile, and when any of the treatment time, the target water removal volume, the predetermined elapsed time, the target water removal achievement rate, and the uniform water removal speed arrival time (Ta) is not input via the input unit during the setting of a new water removal profile, the calculation unit displays a message indicating that there are uninputted items via the output unit. This further reduces the burden on the operator and the number of work steps. Furthermore, by issuing a warning for uninputted items, forgetting to input data can be reduced.

[0151] In an eleventh embodiment of the present disclosure, in the eighth embodiment, if the treatment time, the target water removal volume, the predetermined elapsed time, the target water removal achievement rate, and the uniform water removal speed arrival time were not input via the input unit when the previous water removal profile was set, and if any of the treatment time, the target water removal volume, the predetermined elapsed time, the target water removal achievement rate, and the uniform water removal speed arrival time are not input via the input unit when a new water removal profile is set, the calculation unit selectably displays setting item information related to a water removal profile for conversion setting via the output unit. This further reduces the burden on the operator and the number of work steps.

[0152] A twelfth embodiment of the present disclosure is an information processing device that performs setting processing for blood purification treatment for a patient, and has a calculation unit that sets a water removal profile based on the treatment time of the blood purification treatment, the target water removal amount in the blood purification treatment, the target water removal achievement rate in a specified elapsed time after the start of the blood purification treatment, and the set water removal speed arrival time until the set water removal speed in the blood purification treatment is reached, and the calculation unit is equipped with an equal water removal speed acquisition unit that acquires the set water removal speed, a specified time water removal speed acquisition unit that acquires the specified time water removal speed in the specified elapsed time, and an initial and final water removal speed calculation unit that divides the treatment time into sections based on the specified elapsed time and the set water removal speed arrival time, and calculates the initial water removal speed and final water removal speed based on the section-specific water removal achievement rate of each section.

[0153] In this way, the water removal rate is calculated based on the setting item information of the treatment time, the target water removal volume, the predetermined elapsed time, the target water removal achievement rate at the predetermined elapsed time, and the set water removal rate arrival time, and the water removal profile is automatically set based on the calculation results. Therefore, the water removal profile is automatically set by the operator simply setting items, thereby reducing the burden on the operator and the work hours. In particular, when the target water removal achievement rate and the set water removal rate arrival time are directly input by the operator, an intuitive water removal profile is set. Furthermore, the period from the start to the end of treatment is divided into multiple sections, and the water removal rate and the water removal rate reduction rate are set for each section. Therefore, compared to conventional water removal profiles, the patient's blood pressure stability can be improved and the water removal efficiency can be optimized. For these reasons, this embodiment simplifies the water removal profile setting process while enabling a water removal process that can be adapted to various patients and reduces the burden on the patient.

[0154] A thirteenth embodiment of the present disclosure is a method for setting a water removal profile using a calculation unit to control a water removal pump in blood purification treatment for a patient, the method comprising the steps of: acquiring the treatment time of the blood purification treatment, the target water removal amount in the blood purification treatment, the target water removal achievement rate in a predetermined elapsed time after the start of the blood purification treatment, and the set water removal rate arrival time until the set water removal rate in the blood purification treatment is reached; acquiring the set water removal rate; acquiring the set water removal rate; acquiring the predetermined time water removal rate in the predetermined elapsed time; calculating the start and end water removal rates by dividing the treatment time into sections based on the predetermined elapsed time and the set water removal rate arrival time, and calculating the start and end water removal rates based on the section-specific water removal achievement rate for each section; and setting the water removal profile from the treatment time, the predetermined elapsed time, the set water removal rate, the predetermined time water removal rate, the start and end water removal rate.

[0155] In this way, the water removal rate is calculated based on the setting item information of the treatment time, the target water removal volume, the predetermined elapsed time, the target water removal achievement rate at the predetermined elapsed time, and the set water removal rate arrival time, and the water removal profile is automatically set based on the calculation results. Therefore, the water removal profile is automatically set by the operator simply setting items, thereby reducing the burden on the operator and the work hours. In particular, when the target water removal achievement rate and the set water removal rate arrival time are directly input by the operator, an intuitive water removal profile is set. Furthermore, the period from the start to the end of treatment is divided into multiple sections, and the water removal rate and the water removal rate reduction rate are set for each section. Therefore, compared to conventional water removal profiles, the patient's blood pressure stability can be improved and the water removal efficiency can be optimized. For these reasons, this embodiment simplifies the water removal profile setting process while enabling a water removal process that can be adapted to various patients and reduces the burden on the patient.

[0156] A fourteenth embodiment of the present disclosure is a processing program for setting blood purification treatment for a patient, which acquires the treatment time of the blood purification treatment, the target water removal amount in the blood purification treatment, the target water removal achievement rate at a predetermined elapsed time after the start of the blood purification treatment, and the set water removal rate arrival time until the set water removal rate is reached in the blood purification treatment, acquires the set water removal rate, acquires the predetermined time water removal rate at the predetermined elapsed time, divides the treatment time into sections based on the predetermined elapsed time and the time to reach the set water removal rate, calculates the initial water removal rate and the final water removal rate based on the section-specific water removal achievement rate for each section, and causes a calculation unit to execute a process for setting a water removal profile from the treatment time, the predetermined elapsed time, the set water removal rate, the predetermined time water removal rate, the initial water removal rate, and the final water removal rate.

[0157] In this way, the water removal rate is calculated based on the setting item information of the treatment time, the target water removal volume, the predetermined elapsed time, the target water removal achievement rate at the predetermined elapsed time, and the set water removal rate arrival time, and the water removal profile is automatically set based on the calculation results. Therefore, the water removal profile is automatically set by the operator simply setting items, thereby reducing the burden on the operator and the work hours. In particular, when the target water removal achievement rate and the set water removal rate arrival time are directly input by the operator, an intuitive water removal profile is set. Furthermore, the period from the start to the end of treatment is divided into multiple sections, and the water removal rate and the water removal rate reduction rate are set for each section. Therefore, compared to conventional water removal profiles, the patient's blood pressure stability can be improved and the water removal efficiency can be optimized. For these reasons, this embodiment simplifies the water removal profile setting process while enabling a water removal process that can be adapted to various patients and reduces the burden on the patient. [Explanation of symbols]

[0158] 1. Blood purification unit 1a Blood purification device 1b Consumables section 2 base units 3 Main unit 4. Display 5. Blood Purifier 6. Information Processing Section 7 Internal piping section 8 Extracorporeal Circulation Department 61 Arithmetic unit (acquisition unit) 61a Equal water removal speed calculation section (set water removal speed acquisition section) 61b Predetermined time water removal speed calculation section (predetermined time water removal speed acquisition section) 61c Water removal speed calculation section from beginning to end 62 Storage section 63 Input section 64 Output section L0 blood circuit L1 arterial blood circuit L2 venous blood circuit L3 Dialysis fluid supply pipe (medicinal fluid supply pipe) L4 Dialysis fluid drainage pipe (medication solution drainage pipe) P14 Water removal pump H patient

Claims

1. A blood purification device that administers blood purification therapy to a patient, a calculation unit that sets a water removal profile based on the treatment time of the blood purification treatment, the target water removal amount in the blood purification treatment, the target water removal achievement rate in a predetermined time elapsed since the start of the blood purification treatment, and the set water removal speed reaching time required to reach the set water removal speed in the blood purification treatment, The calculation unit A set water removal rate acquisition unit that acquires the set water removal rate; A predetermined time water removal rate acquisition unit that acquires a predetermined time water removal rate at the predetermined elapsed time; A blood purification device comprising an initial and final water removal rate calculation unit that divides the treatment time into sections based on the specified elapsed time and the time to reach the set water removal rate, and calculates the initial water removal rate and final water removal rate based on the water removal amount for each section.

2. The set water removal speed is a uniform water removal speed, The set water removal speed reaching time is an equal water removal speed reaching time until the equal water removal speed is reached, The blood purification device of claim 1, wherein the calculation unit includes an equal water removal rate calculation unit that calculates the equal water removal rate from the treatment time and the target water removal volume, and a predetermined time water removal rate calculation unit that calculates the predetermined time water removal rate at the predetermined elapsed time by multiplying the equal water removal rate by a predetermined constant.

3. The blood purification device of claim 2, wherein the start / end water removal rate calculation unit calculates, when the uniform water removal rate arrival time is reached before the predetermined elapsed time, a first section water removal amount from the start of treatment to the uniform water removal rate arrival time, a second section water removal amount from the uniform water removal rate arrival time to the predetermined elapsed time, and a third section water removal amount from the predetermined elapsed time to the end of treatment.

4. The start and end water removal rate calculation unit The second section water removal amount is calculated from the uniform water removal rate arrival time, the uniform water removal rate, the predetermined elapsed time, and the predetermined time water removal rate, Calculating the first section water removal amount from the target water removal amount, the target water removal achievement rate, and the second section water removal amount; The initial water removal rate is calculated from the first section water removal amount, the uniform water removal rate arrival time, and the uniform water removal rate; The third section water removal amount is calculated from the target water removal amount, the first section water removal amount, and the second section water removal amount; The blood purification apparatus according to claim 3 , wherein the terminal water removal rate is calculated based on the third interval water removal amount, the treatment time, the predetermined elapsed time, and the predetermined time water removal rate.

5. The blood purification device of claim 2, wherein the start / end water removal rate calculation unit calculates, when the uniform water removal rate arrival time is reached after the predetermined elapsed time, a first section water removal amount from the start of treatment to the predetermined elapsed time, a second section water removal amount from the predetermined elapsed time to the uniform water removal rate arrival time, and a third section water removal amount from the uniform water removal rate arrival time to the end of treatment.

6. The start and end water removal rate calculation unit The first section water removal amount is calculated from the target water removal amount and the target water removal achievement rate, The initial water removal rate is calculated from the first section water removal amount, the uniform water removal rate arrival time, and the uniform water removal rate; The second section water removal amount is calculated from the uniform water removal rate arrival time, the uniform water removal rate, the predetermined elapsed time, and the predetermined time water removal rate, The third section water removal amount is calculated from the target water removal amount, the first section water removal amount, and the second section water removal amount; The blood purification apparatus according to claim 5, wherein the terminal water removal rate is calculated based on the third interval water removal amount, the treatment time, the predetermined elapsed time, and the predetermined time water removal rate.

7. The blood purification apparatus according to claim 2, further comprising an input unit for inputting the treatment time, the target water removal amount, the target water removal achievement rate, and the time to reach the uniform water removal rate.

8. a storage unit that stores past water removal profiles; An output unit that outputs the past water removal profile, The blood purification apparatus according to claim 7 , wherein when setting item information relating to the past water removal profile is selected via the input unit, the calculation unit sets the water removal profile based on the setting item information.

9. The blood purification device of claim 8, wherein the calculation unit, when no input is made via the input unit for the treatment time, the target water removal volume, the specified elapsed time, the target water removal achievement rate, or the time to reach the uniform water removal speed, selectably displays setting item information relating to the past water removal profile via the output unit.

10. The blood purification device of claim 8, wherein the calculation unit displays via the output unit that there are items that have not been input when the treatment time, the target water removal volume, the specified elapsed time, the target water removal achievement rate, and the uniform water removal speed arrival time were input via the input unit when the previous water removal profile was set, and when a new water removal profile is set, if any of the treatment time, the target water removal volume, the specified elapsed time, the target water removal achievement rate, and the uniform water removal speed arrival time is not input via the input unit.

11. The blood purification device of claim 8, wherein the calculation unit selectably displays setting item information related to a water removal profile for conversion setting via the output unit if the treatment time, the target water removal volume, the specified elapsed time, the target water removal achievement rate, and the uniform water removal speed arrival time were not input via the input unit when the previous water removal profile was set, and if the treatment time, the target water removal volume, the specified elapsed time, the target water removal achievement rate, and the uniform water removal speed arrival time are not input via the input unit when a new water removal profile is set.

12. An information processing device that performs setting processing for blood purification treatment for a patient, a calculation unit that sets a water removal profile based on the treatment time of the blood purification treatment, the target water removal amount in the blood purification treatment, the target water removal achievement rate in a predetermined time elapsed since the start of the blood purification treatment, and the set water removal speed reaching time required to reach the set water removal speed in the blood purification treatment, The calculation unit An equal water removal speed acquisition unit that acquires the set water removal speed; A predetermined time water removal rate acquisition unit that acquires a predetermined time water removal rate at the predetermined elapsed time; An information processing device comprising: an initial and final water removal rate calculation unit that divides the treatment time into sections based on the specified elapsed time and the time to reach the set water removal rate, and calculates the initial water removal rate and final water removal rate based on the section-specific water removal achievement rate of each section.

13. A method for setting a water removal profile for controlling a water removal pump in blood purification therapy for a patient, the method comprising: an acquiring step of acquiring the treatment time of the blood purification treatment, the target water removal amount in the blood purification treatment, the target water removal achievement rate in a predetermined time elapsed since the start of the blood purification treatment, and the set water removal rate attainment time required to reach the set water removal rate in the blood purification treatment; A set water removal rate acquisition step of acquiring the set water removal rate; A predetermined time water removal rate acquisition step of acquiring a predetermined time water removal rate at the predetermined elapsed time; A step of calculating an initial and final water removal rate by dividing the treatment time into sections based on the predetermined elapsed time and the set water removal rate arrival time, and calculating an initial water removal rate and a final water removal rate based on the water removal achievement rate for each section; A method for setting a water removal profile, comprising a setting step of setting a water removal profile from the treatment time, the specified elapsed time, the set water removal rate, the specified time water removal rate, the initial water removal rate, and the final water removal rate.

14. A processing program for performing setting processing for blood purification treatment for a patient, Acquire the treatment time of the blood purification treatment, the target water removal amount in the blood purification treatment, the target water removal achievement rate in a predetermined elapsed time after the start of the blood purification treatment, and the set water removal speed reaching time until the set water removal speed in the blood purification treatment is reached, The set water removal speed is acquired, A predetermined time water removal rate is obtained at the predetermined elapsed time, The treatment time is divided into sections based on the predetermined elapsed time and the set water removal rate arrival time, and the initial water removal rate and the final water removal rate are calculated based on the water removal achievement rate for each section, A processing program that causes a calculation unit to execute a process for setting a water removal profile from the treatment time, the specified elapsed time, the set water removal rate, the specified time water removal rate, the initial water removal rate, and the final water removal rate.

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