Magnesium ion-containing materials as white pigments in oral care compositions

Abstract

The present invention relates to oral care compositions comprising a magnesium ion-containing material in an amount of 0.1 to 40% by weight, based on the total weight of the composition, and to the use of the magnesium ion-containing material as an opacifying agent and / or whitening pigment in oral care compositions.

Description

[Technical Field]

[0001] The present invention relates to oral care compositions comprising a magnesium ion-containing material in an amount of 0.1 to 40% by weight, based on the total weight of the composition, and to the use of the magnesium ion-containing material as an opacifying agent and / or whitening pigment in oral care compositions. [Background technology]

[0002] A wide variety of oral care products are used to clean, protect, and maintain teeth and their structure. For example, International Publication No. 2000 / 010520A1 refers to a toothpaste containing particulate calcium carbonate as the main abrasive cleaning agent in a liquid or paste medium, characterized in that the particulate calcium carbonate comprises a mixture of 75 to 92.5% by weight of mixed fine particles of calcium carbonate having a weight-average particle size of 1 to 15 μm and 7.5 to 25% by weight of coarse particulate calcium carbonate having a weight-average particle size of 30 to 120 μm. European Patent Application Publication No. 2461794A2 refers to a toothpaste composition containing a binder, an abrasive, a foaming agent, water, and polyethylene glycol, the binder comprising semi-refined iota-carrageenan. U.S. Patent Application Publication No. 2009 / 0117058A1 refers to a whitening toothpaste composition having improved shelf life and sustained tooth whitening effect, characterized in that the toothpaste composition contains peroxide and purified silica. International Publication No. 2014 / 059678A1 refers to a toothpaste composition comprising an orally acceptable vehicle; an abrasive containing calcium carbonate; and a binder system containing guar gum and at least one cellulose polymer, wherein the binder system is substantially free of magnesium aluminum silicate. U.S. Pat. No. 4,254,101A refers to a toothpaste composition comprising: (A) about 6% to 45% silica dental abrasive; (B) about 30% to 70% humectant; (C) about 0.03% to 1.0% carboxyvinyl polymer; and (D) about 10% to 45% water, which provides a pH of about 4.0 to 8.0 when slurried with water in a water / composition weight ratio of 3:1.WO 2013 / 007571A2 refers to a toothpaste composition comprising (i) a calcium-based abrasive; (ii) a copolymer of vinyl methyl ether and maleic acid; and (iii) clay, wherein the ratio of calcium-based abrasive to the copolymer of vinyl methyl ether and maleic anhydride is at least 1:0.0075 and the ratio of calcium-based abrasive to the clay is at least 1:0.02. WO 2012 / 143220A1 describes a composition suitable for tooth remineralization and whitening, comprising a calcium source and a calcium salt of a regenerating source. WO 2013 / 034421A2 describes a dentifrice composition comprising a water-insoluble and / or slightly water-soluble calcium source and an organic acid or a physiologically acceptable salt thereof. WO 2012 / 031786A2 relates to an oral care composition comprising a composite particulate active agent having a core and a coating, wherein the coating interacts with phosphate ions to produce a reaction product of calcium and phosphate, which is suitable for adhering to tooth enamel and / or dentin to improve tooth properties.

[0003] Usually, these products have their appearance modified to meet consumer expectations. For example, from the consumer's point of view, white and opaque products are desired. Currently, titanium dioxide is widely applied as a white pigment in oral care products. For example, U.S. Pat. No. 3,935,304 A refers to a toothpaste containing an abrasive system comprising at least about 25% by weight of dispersed sodium bicarbonate particles and titanium dioxide powder having a particle size of less than about 2 μm, wherein the amount of titanium dioxide particles is greater than about 0.1% by weight of the toothpaste; the particles dispersed in the vehicle contain sufficient liquid; the vehicle consists essentially of about 5-35% water and a water-miscible polyol humectant or mixture thereof of sufficient viscosity, and a sufficient amount of gelling agent or thickener to impart to the toothpaste the paste consistency, body, and non-stickiness characteristic of conventional toothpastes or toothpastes; the sodium bicarbonate is primarily in an undissolved solid state; and the toothpaste has a granular textured appearance, comprising amorphous-appearing grains of fine crystalline bicarbonate granules substantially dispersed in an otherwise smooth, continuous matrix.

[0004] However, due to the possible health risks of titanium dioxide in these products, and especially of such nanoparticles, there are strong concerns about the use of titanium dioxide in such compositions.Calcium carbonate is also known as a white pigment in a wide range of products.Calcium carbonate, such as ground calcium carbonate, precipitated calcium carbonate, and their mixtures, has significant disadvantages compared to titanium dioxide, and therefore is not considered as a material choice in oral care products.In particular, oral care products typically contain fluoride ions to prevent tooth decay and caries.This fluoride can be provided as sodium fluoride.However, fluoride ions are strongly adsorbed on the surface of calcium carbonate as calcium fluoride, and therefore, this makes fluoride ions unavailable for interaction with teeth.

[0005] However, providing oral care compositions that do not contain titanium dioxide remains of interest to those skilled in the art. Furthermore, it is desirable to provide oral care compositions that provide sufficient whiteness and / or opacity. Furthermore, it is desirable to provide oral care compositions that provide high availability of fluoride ions in the compositions. Summary of the Invention [Problem to be solved by the invention]

[0006] Accordingly, it is an object of the present invention to provide an oral care composition that is preferably free of titanium dioxide. A further object of the present invention is to provide an oral care composition that provides sufficient whiteness and / or opacity. A further object of the present invention is to provide an oral care composition that provides a high availability of fluoride ions in the composition, particularly compared to compositions containing calcium carbonate. [Means for solving the problem]

[0007] These and other objects are solved by the subject matter defined herein in the independent claims.

[0008] According to one aspect of the present invention, there is provided an oral care composition comprising a magnesium ion-containing material in an amount of 0.1 to 40 wt % based on the total weight of the composition.

[0009] According to another aspect of the present invention there is provided the use of a magnesium ion-containing material as an opacifying and / or whitening pigment in an oral care composition.

[0010] The inventors have surprisingly found that the oral care compositions described above, while free of titanium dioxide, provide sufficient whiteness and / or opacity, as well as high availability of fluoride ions. More precisely, the inventors have found that when an amount of 0.1 to 40% by weight of a magnesium ion-containing material is used in the composition, the oral care composition provides sufficient whiteness and / or opacity, and also high availability of fluoride ions.

[0011] Advantageous embodiments of the oral care compositions and uses according to the invention are defined in the corresponding dependent claims.

[0012] According to one embodiment, the magnesium ion containing material is anhydrous magnesium carbonate or magnesite (MgCO3), hydromagnesite (Mg5(CO3)4(OH)2·4H2O), artinite (Mg2(CO3)(OH)2·3H2O), diepingite (Mg5(CO3)4(OH)2·5H2O), georgiosite (Mg5(CO3)4(OH)2·5H2O), pokrovskite (Mg2(CO3)(OH)2·0.5H2O), barlintonite (MgCO3·2H2O), It is selected from the group consisting of lansfordite (MgCO3·5H2O), nesquehonite (MgCO3·3H2O), brucite (Mg(OH)2), dolomite (CaMg(CO3)2), hydrocarbonate, and mixtures thereof, and is preferably selected from anhydrous magnesium carbonate or magnesite (MgCO3), dolomite (CaMg(CO3)2), hydromagnesite (Mg5(CO3)4(OH)2·4H2O), brucite (Mg(OH)2), and mixtures thereof.

[0013] According to another embodiment, the magnesium ion-containing material is in the form of particles having: (a) A volume median particle size (d) determined by laser diffraction of ≥ 150 nm, preferably 150 nm to 20 μm, more preferably 0.2 to 15 μm, even more preferably 0.5 to 10 μm, and most preferably 1 to 5 μm. 50 ), and / or (b) a volume-determined top-cut particle size (d) of 30 μm or less, preferably 2 to 30 μm, more preferably 5 to 20 μm, and most preferably 8 to 18 μm, as determined by laser diffraction 98 ).

[0014] According to yet another embodiment, the magnesium ion-containing material has a CIELAB L solubility of >90%, preferably >95%, more preferably >98%, most preferably >98.5%, measured dry according to EN ISO 11664 4:2010. * The whiteness is determined as follows:

[0015] According to one embodiment, the magnesium ion-containing material has a magnesium ion content of 2 to 200 m as measured using nitrogen and the BET method according to ISO 9277:2010. 2 / g, preferably 10 to 100m 2 / g, most preferably 12 to 75 m 2 The powder is in the form of particles having a BET specific surface area of ​​1 / g.

[0016] According to yet another embodiment, the oral care composition further comprises a fluoride compound, preferably the fluoride compound is selected from the group consisting of sodium fluoride, stannous fluoride, sodium monofluorophosphate, potassium fluoride, potassium stannous fluoride, sodium fluorostannate, stannous chloride fluoride, amine fluorides, and mixtures thereof, more preferably the fluoride compound is sodium monofluorophosphate and / or sodium fluoride.

[0017] According to one embodiment, the oral care composition further comprises a remineralizing and / or whitening agent, preferably selected from the group consisting of silica; hydroxylapatite, such as nanohydroxylapatite; calcium carbonate, such as amorphous calcium carbonate, ground calcium carbonate, precipitated calcium carbonate, surface-reacted calcium carbonate, and combinations thereof; calcium silicate; and mixtures thereof.

[0018] According to another embodiment, the oral care composition is a toothpaste, tooth gel, tooth powder, varnish, adhesive gel, cement, resin, spray, foam, balm, a composition embodied in a mouth strip or buccal adhesive patch, chewable tablet, chewable troche, chewable gum, lozenge, beverage, or mouthwash, preferably a chewable gum, lozenge, toothpaste, tooth powder, or mouthwash, most preferably a toothpaste.

[0019] According to yet another embodiment, the oral care composition has a pH of 6.8-10, preferably 7.5-9, and most preferably 8-9.

[0020] According to one embodiment, the oral care composition comprises the magnesium ion-containing material in an amount of 0.5 to 10% by weight, based on the total weight of the composition.

[0021] Where an indefinite or definite article is used when referring to a singular noun e.g. "a", "an" or "the", this includes the plural of that noun unless otherwise stated.

[0022] Where the term "comprising" is used in the present description and claims, it does not exclude other elements. For the purposes of the present invention, the term "consisting of" is considered to be a preferred embodiment of the term "comprising". Hereinafter, when a group is defined to include at least a certain number of embodiments, this should also be understood to disclose a group that preferably consists only of these embodiments.

[0023] "Obtainable" or "definable" and "obtained" or "defined" are used interchangeably. This means, for example, that unless the context clearly dictates otherwise, the term "obtained" does not imply that an embodiment must be obtained by, for example, the sequence of steps following the term "obtained," but that such a limited understanding is always included as a preferred embodiment by the term "obtained" or "defined."

[0024] Whenever the terms "including" or "having" are used, these terms are intended to be equivalent to "comprising" as defined above. DETAILED DESCRIPTION OF THE INVENTION

[0025] In the following, preferred embodiments of the oral care composition according to the invention are described in more detail, it being understood that these embodiments and details also apply to the uses according to the invention, where applicable.

[0026] Oral care composition According to the present invention, there is provided an oral care composition, which comprises a magnesium ion-containing material in an amount of 0.1 to 40% by weight, based on the total weight of the composition.

[0027] The term "magnesium ion-containing material" is understood to refer to a material containing at least 38% by weight of magnesium compounds. In one embodiment, the magnesium ion-containing material contains at least 38% by weight, preferably 38-100% by weight, more preferably 38-99.95% by weight, e.g., 38-55% by weight, of magnesium compounds, based on the total dry weight of the material. In another embodiment, the magnesium ion-containing material contains at least 85% by weight, preferably 85-100% by weight, more preferably 90-99.95% by weight, of magnesium compounds, based on the total dry weight of the material. It should be noted, therefore, that the magnesium ion-containing material may further contain impurities typically associated with the type of material used. For example, the magnesium ion-containing material may further contain impurities, such as calcium ion-containing materials, such as calcium hydroxide, calcium carbonate, and mixtures thereof.

[0028] For example, when the magnesium ion-containing material contains magnesium compounds in an amount of at least 38 wt%, preferably 38-100 wt%, more preferably 38-99.95 wt%, e.g., 38-45 wt%, based on the total dry weight of the material, impurities such as calcium ion-containing materials, such as calcium hydroxide, calcium carbonate, and mixtures thereof, are present in an amount of less than 62 wt%, preferably 0-62 wt%, more preferably 0.05-62 wt%, e.g., 45-62 wt%, based on the total dry weight of the material. When the magnesium ion-containing material contains magnesium compounds in an amount of at least 85 wt%, preferably 85-100 wt%, more preferably 90-99.95 wt%, based on the total dry weight of the material, impurities such as calcium ion-containing materials, such as calcium hydroxide, calcium carbonate, and mixtures thereof, are present in an amount of less than 15 wt%, most preferably 0.05-10 wt%, based on the total dry weight of the material. It is further understood that the magnesium ion-containing material may be a mineral phase containing calcium and magnesium ions, for example, dolomite (MgCa(CO3)2).

[0029] The magnesium ion-containing material may be a naturally occurring or synthetic magnesium ion-containing material.

[0030] According to one embodiment of the invention, the naturally occurring magnesium ion-containing material may be obtained by dry grinding. According to another embodiment of the invention, the naturally occurring magnesium ion-containing material may be obtained by wet grinding and optionally subsequent drying.

[0031] Generally, the crushing step can be carried out using conventional crushing equipment, for example, under conditions where crushing occurs primarily as a result of impact with secondary objects, i.e., in one or more of the following devices: ball mills, rod mills, vibratory mills, roll crushers, centrifugal impact mills, vertical bead mills, attrition crushers, pin mills, hammer mills, pulverizers, shredders, declampers, knife cutters, or other such equipment known to those skilled in the art. If the magnesium ion-containing material is obtained by wet crushing, the crushing step can be carried out under conditions where autogenous crushing occurs, and / or by horizontal ball milling and / or other such processes known to those skilled in the art. The wet-processed crushed magnesium ion-containing material thus obtained can be washed and dewatered by well-known processes, for example, by flocculation, filtration, or forced evaporation before drying. The subsequent drying step can be carried out in a single step, such as spray drying, or in at least two steps. It is also common for such mineral materials to undergo beneficiation steps (e.g., flotation, bleaching, or magnetic separation steps) to remove impurities.

[0032] Within the meaning of the present invention, synthetic magnesium ion-containing materials can be obtained by processes well known in the art. For example, U.S. Pat. No. 1,361,324, U.S. Pat. No. 935,418, British Patent No. 548,197, and British Patent No. 544,907 generally describe the formation of an aqueous solution of magnesium bicarbonate (typically described as "Mg(HCO3)2"), which is then converted by the action of a base, e.g., magnesium hydroxide, to form hydromagnesite. Other processes described in the art suggest preparing a composition containing both hydromagnesite and magnesium hydroxide, in which the magnesium hydroxide is mixed with water to form a suspension, which is further contacted with carbon dioxide and an aqueous basic solution to form a corresponding mixture. See, for example, U.S. Pat. No. 5,979,461. European Patent No. 0,526,121 describes a calcium-magnesium carbonate complex consisting of calcium carbonate and magnesium carbonate hydroxide, as well as a method for its preparation. Furthermore, GB Patent No. 594262 relates to a method and apparatus for processing magnesia-containing materials, such as magnesium carbonate and calcium carbonate materials, to obtain different and distinct forms of each carbonate, wherein controlled carbonation allows the magnesium carbonate and calcium carbonate to be separated by mechanical means and achieves particular utility in the separated products. US Patent Application Publication No. 2007 / 194276 describes a method for reductively bleaching a mineral slurry, the method comprising adding to the mineral slurry an effective amount of formamidine sulfinic acid (FAS) and an effective amount of borohydride to reductively bleach the mineral slurry.

[0033] For example, magnesium ion-containing materials include anhydrous magnesium carbonate or magnesite (MgCO3), hydromagnesite (Mg5(CO3)4(OH)2·4H2O), artinite (Mg2(CO3)(OH)2·3H2O), daipingite (Mg5(CO3)4(OH)2·5H2O), georgiosite (Mg5(CO3)4(OH)2·5H2O), pokrovskite (Mg2(CO3)(OH)2·0.5H2O), barlintonite (MgCO3·2H2O), lansfordite (MgCO3·5H2O), and tetramethylammonium carbonate (MgCO3·5H2O). 2O), nesquehonite (MgCO3 3H2O), brucite (Mg(OH)2), dolomite (CaMg(CO3)2), dolocarbonate, and mixtures thereof, preferably anhydrous magnesium carbonate or naturally occurring or synthetic magnesium ion-containing material selected from magnesite (MgCO3), dolomite (CaMg(CO3)2), hydromagnesite (Mg5(CO3)4(OH)2 4H2O), brucite (Mg(OH)2), and mixtures thereof.

[0034] In the sense of the present invention, the term "dorocarbonate" refers to a composite material comprising a magnesium mineral, preferably hydromagnesite (Mg5(CO3)4(OH)2·4H2O), and calcium carbonate, aggregated at the primary particle level. Such dorocarbonates are described, for example, in WO 2013 / 139957 A1 and WO 2015 / 039994 A1, which are hereby incorporated by reference.

[0035] Preferably, the magnesium ion-containing material comprises anhydrous magnesium carbonate or a naturally occurring or synthetic magnesium ion-containing material selected from the group consisting of magnesite (MgCO), hydromagnesite (Mg(CO)(OH)·4H0), nesquehonite (MgCO·3H0), brucite (Mg(OH)), dolomite (CaMg(CO)), dolocarbonate, and mixtures thereof. For example, the magnesium ion-containing material comprises anhydrous magnesium carbonate or a naturally occurring or synthetic magnesium carbonate selected from the group consisting of magnesite (MgCO), hydromagnesite (Mg(CO)(OH)·4H0), nesquehonite (MgCO·3H0), brucite (Mg(OH)), dolomite (CaMg(CO)), dolocarbonate, and mixtures thereof, in an amount of at least 80 wt.%, more preferably at least 85 wt.%, even more preferably 85-100 wt.%, and most preferably 90-99.95 wt.%, based on the total dry weight of the material.

[0036] In one embodiment, the magnesium ion-containing material comprises anhydrous magnesium carbonate or magnesite (MgCO) and / or dolomite (CaMg(CO)) and / or hydromagnesite (Mg(CO)(OH)·4H0) and / or brucite (Mg(OH)), preferably synthetic hydromagnesite (Mg(CO)(OH)·4H0) and / or brucite (Mg(OH)) and / or naturally occurring anhydrous magnesium carbonate or magnesite (MgCO) and / or dolomite (CaMg(CO)). Preferably, the magnesium ion-containing material comprises anhydrous magnesium carbonate or magnesite (MgCO3) and / or dolomite (CaMg(CO3)2) and / or hydromagnesite (Mg5(CO3)4(OH)2 4H2O) and / or brucite (Mg(OH)2), preferably synthetic hydromagnesite (Mg5(CO3)4(OH)2 4H2O) and / or brucite (Mg(OH)2) and / or naturally occurring anhydrous magnesium carbonate or magnesite (MgCO3) and / or dolomite (CaMg(CO3)2), in an amount of at least 80 wt.%, more preferably at least 85 wt.%, even more preferably 85-100 wt.%, and most preferably 90-99.95 wt.%, based on the total dry weight of the material.

[0037] For example, the magnesium ion-containing material includes anhydrous magnesium carbonate or magnesite (MgCO) or dolomite (CaMg(CO)) or hydromagnesite (Mg(CO)(OH)·4H0) or brucite (Mg(OH)), e.g., synthetic hydromagnesite (Mg(CO)(OH)·4H0) or brucite (Mg(OH)), preferably hydromagnesite (Mg(CO)(OH)·4H0), e.g., synthetic hydromagnesite (Mg(CO)(OH)·4H0), or naturally occurring anhydrous magnesium carbonate or magnesite (MgCO) or dolomite (CaMg(CO)). For example, the magnesium ion-containing material includes anhydrous magnesium carbonate or magnesite (MgCO), e.g., naturally occurring anhydrous magnesium carbonate or magnesite (MgCO). Alternatively, the magnesium ion-containing material comprises dolomite (CaMg(CO3)2), for example, naturally occurring dolomite (CaMg(CO3)2). In one embodiment, the magnesium ion-containing material comprises anhydrous magnesium carbonate or magnesite (MgCO3) or dolomite (CaMg(CO3)2) or hydromagnesite (Mg5(CO3)4(OH)2 4H2O) or brucite (Mg(OH)2), for example, synthetic hydromagnesite (Mg5(CO3)4(OH)2 4H2O) or brucite (Mg(OH)2) or naturally occurring anhydrous magnesium carbonate or magnesite (MgCO3) or dolomite (CaMg(CO3)2), in an amount of at least 80 wt.%, more preferably at least 85 wt.%, even more preferably 85-100 wt.%, and most preferably 90-99.95 wt.%, based on the total dry weight of the material.

[0038] In one embodiment, the magnesium ion-containing material comprises anhydrous magnesium carbonate or magnesite (MgCO) and / or dolomite (CaMg(CO)), such as naturally occurring anhydrous magnesium carbonate or magnesite (MgCO) or dolomite (CaMg(CO)).

[0039] In an alternative embodiment, the magnesium ion-containing material comprises hydromagnesite (Mg5(CO3)4(OH)2·4H2O) or brucite (Mg(OH)2), for example, synthetic hydromagnesite (Mg5(CO3)4(OH)2·4H2O) or brucite (Mg(OH)2), preferably hydromagnesite (Mg5(CO3)4(OH)2·4H2O), for example, synthetic hydromagnesite (Mg5(CO3)4(OH)2·4H2O).

[0040] The oral care composition preferably does not contain nano-sized (white) pigment particles, such as nano-sized titanium dioxide, and therefore the magnesium ion-containing material preferably does not contain particles having a primary particle size of <100 nm.

[0041] According to one embodiment of the present invention, the magnesium ion-containing material has a volume median particle size (d ) determined by laser diffraction of ≥ 150 nm, preferably 150 nm to 20 μm, more preferably 0.2 to 15 μm, even more preferably 0.5 to 10 μm, and most preferably 1 to 5 μm. 50 According to a further embodiment of the present invention, the magnesium ion-containing material is in the form of particles having a volume-determined top cut particle size (d ) of 30 μm or less, preferably 2 to 30 μm, more preferably 5 to 20 μm, and most preferably 8 to 18 μm, as determined by laser diffraction. 98 ) in the form of particles.

[0042] Thus, the magnesium ion-containing material is in the form of particles that preferably have: (a) A volume median particle size (d) determined by laser diffraction of ≥ 150 nm, preferably 150 nm to 20 μm, more preferably 0.2 to 15 μm, even more preferably 0.5 to 10 μm, and most preferably 1 to 5 μm. 50 ), and (b) a volume-determined top-cut particle size (d) of 30 μm or less, preferably 2 to 30 μm, more preferably 5 to 20 μm, and most preferably 8 to 18 μm, as determined by laser diffraction 98 ).

[0043] In one embodiment of the present invention, the magnesium ion-containing material has a volume median particle size (d 50 ), and the volume-determined top-cut particle size (d 98 ) in the form of particles.

[0044] For example, the magnesium ion-containing material may include anhydrous magnesium carbonate or magnesite (MgCO3) or dolomite (CaMg(CO3)2) or hydromagnesite (Mg5(CO3)4(OH)2 4H2O) or brucite (Mg(OH)2), such as synthetic hydromagnesite (Mg5(CO3)4(OH)2 4H2O) or brucite (Mg(OH)2), or naturally occurring anhydrous magnesium carbonate or magnesite (MgCO3) or dolomite (CaMg(CO3)2), and have a volume median particle size (d) of 1 to 5 μm, as determined by laser diffraction. 50 ), and the volume-determined top-cut particle size (d 98 )

[0045] In one embodiment, the magnesium ion-containing material comprises anhydrous magnesium carbonate or magnesite (MgCO3) or dolomite (CaMg(CO3)2) or hydromagnesite (Mg5(CO3)4(OH)2 4H2O) or brucite (Mg(OH)2), for example, synthetic hydromagnesite (Mg5(CO3)4(OH)2 4H2O) or brucite (Mg(OH)2), or naturally occurring anhydrous magnesium carbonate or magnesite (MgCO3) or dolomite (CaMg(CO3)2), in an amount of at least 80 wt. %, more preferably at least 85 wt. %, even more preferably 85-100 wt. %, and most preferably 90-99.95 wt. %, based on the total dry weight of the material, and has a volume median particle size (d) of 1-5 μm, as determined by laser diffraction. 50 ), and the volume-determined top-cut particle size (d 98 )

[0046] Volume-determined median particle size d 50 (or d 50 (vol)) and volume-determined top cut particle size d 98 (or d 98 (vol)) was assessed using a Malvern Mastersizer 3000 Laser Diffraction System equipped with a Hydro LV system (Malvern Instruments Plc., Great Britain). 50 (vol) or d 98 The (vol) values ​​indicate the diameter values ​​where 50% or 98% by volume of the particles, respectively, have a diameter less than this value. The powder was suspended in a 0.1 wt% Na4O7P2 solution. 10 mL of 0.1 wt% Na4O7P2 was added to the Hydro LV tank, and then the sample slurry was introduced until 10-20% darkening was achieved. Measurements were taken with red and blue light for 10 seconds each. For analysis of the raw data, a model for non-spherical particle size using Mie theory was used, with a particle refractive index of 1.57 and a density of 2.70 g / cm3. 3 The absorption coefficient was taken to be 0.005. This method and instrument are known to those skilled in the art and are commonly used to determine particle size distributions of fillers and pigments.

[0047] Additionally or alternatively, the magnesium ion-containing material has a CIELAB L solubility of >90%, preferably >95%, more preferably >98%, and most preferably >98.5%, measured dry according to EN ISO 11664 4:2010. * The whiteness is determined as follows:

[0048] In one embodiment, the magnesium ion-containing material has a magnesium ion content of 2 to 200 m as measured using nitrogen and the BET method according to ISO 9277:2010. 2 / g, preferably 10 to 100m 2 / g, most preferably 12 to 75 m 2 The powder is in the form of particles having a BET specific surface area of ​​1 / g.

[0049] The "specific surface area" (m 2 The solubility (expressed in saturates / g) can be determined by the Brunauer-Emmett-Teller (BET) method using nitrogen as the adsorption gas and by using an ASAP 2460 instrument from Micromeritics. This method is well known to those skilled in the art and is defined in ISO 9277:2010. The sample is conditioned under vacuum at 150°C for 60 minutes before measurement.

[0050] In one embodiment, the magnesium ion-containing material contains up to 25000 ppm of Ca 2+ For example, the magnesium ion-containing material may contain up to 20,000 ppm of Ca, more preferably up to 15,000 ppm, and most preferably up to 5,000 ppm. 2+ Contains ions.

[0051] The magnesium ion-containing material according to the present invention is preferably not obtained by treating the surface of a magnesium ion-containing material with a surface treatment agent, and therefore is preferably not surface-treated.

[0052] According to the present invention, the oral care composition comprises the magnesium ion-containing material in an amount of 0.1 to 40% by weight, based on the total weight of the composition.

[0053] According to one embodiment of the present invention, the magnesium ion-containing material is present in an amount of 0.1 to 30 wt %, preferably 0.1 to 20 wt %, more preferably 0.5 to 15 wt %, and most preferably 0.5 to 10 wt %, based on the total weight of the composition.

[0054] According to another embodiment, the oral care composition may include at least one whitening and / or remineralizing agent, it being understood that such whitening agents are typically added to whiten teeth rather than to whiten the oral care composition (such as magnesium ion-containing materials).

[0055] The whitening agent may be a bleaching agent, an abrasive, or a remineralizing agent, and is preferably selected from the group consisting of hydrogen peroxide, carbamide peroxide, hydroxylapatite, calcium carbonate, and mixtures thereof.

[0056] According to one embodiment of the present invention, the at least one remineralizing and / or whitening agent is selected from the group consisting of silica; hydroxylapatite, e.g., nanohydroxylapatite; calcium carbonate, e.g., amorphous calcium carbonate, ground calcium carbonate, precipitated calcium carbonate, surface-reacted calcium carbonate, and combinations thereof; calcium silicate; and mixtures thereof.

[0057] According to one embodiment, the remineralizing and / or whitening agent has a weight median particle size d of 10 nm to 100 μm, preferably 0.1 to 50 μm, more preferably 1 to 20 μm, most preferably 2 to 10 μm. 50 Preferably,

[0058] If present, the at least one remineralizing and / or whitening agent may be present in the oral care composition in an amount of 1 to 20% by weight, preferably 1.5 to 15% by weight, more preferably 2 to 10% by weight, based on the total weight of the composition.

[0059] According to one embodiment, the oral care composition of the present invention comprises 0.1 to 40% by weight of a magnesium ion-containing material and 1 to 20% by weight of a remineralizing and / or whitening agent, based on the total weight of the composition.

[0060] The oral care composition of the present invention may be, for example, a toothpaste, tooth gel, tooth powder, varnish, adhesive gel, cement, resin, spray, foam, balm, a composition embodied in a mouth strip or buccal adhesive patch, a chewable tablet, a chewable troche, a chewable gum, a lozenge, a beverage, or a mouthwash.

[0061] According to one embodiment of the present invention, the oral care composition is a chewable gum, lozenge, toothpaste, tooth powder, or mouthwash, preferably a toothpaste.

[0062] According to another preferred embodiment, the oral care composition is a toothpaste, tooth powder, or mouthwash, and the magnesium ion-containing material has a volume median particle size (d), as determined by laser diffraction, of ≥ 150 nm, preferably 150 nm to 20 μm, more preferably 0.2 to 15 μm, even more preferably 0.5 to 10 μm, and most preferably 1 to 5 μm. 50 ), and a volume-determined top-cut particle size (d ) of 30 μm or less, preferably 2 to 30 μm, more preferably 5 to 20 μm, and most preferably 8 to 18 μm, as determined by laser diffraction. 98 ) in the form of particles.

[0063] Preferably, the oral care composition is a toothpaste, tooth powder, or mouthwash, and the magnesium ion-containing material has a volume median particle size (d) of 1 to 5 μm, as determined by laser diffraction. 50 ), and the volume-determined top-cut particle size (d 98 ) in the form of particles.

[0064] According to one embodiment of the present invention, the oral care composition has a pH of 6.8-10, preferably 7.5-9, most preferably 8-9.

[0065] The oral care composition of the present invention can be used in combination with fluoride compounds.The inventor has surprisingly found that the presence of magnesium ion-containing material in the oral care composition of the present invention makes the composition highly available for fluoride ions.Therefore, the actual amount of fluoride compounds in the composition can be reduced, especially compared with compositions containing calcium carbonate.

[0066] According to a preferred embodiment, the oral care composition further comprises a fluoride compound selected from the group consisting of sodium fluoride, stannous fluoride, sodium monofluorophosphate, potassium fluoride, potassium stannous fluoride, sodium fluorostannate, stannous chloride fluoride, amine fluorides, and mixtures thereof. Preferably, the fluoride compound is sodium monofluorophosphate and / or sodium fluoride.

[0067] Good results can be achieved by using an amount of fluoride compound in an amount that provides available fluoride ions in the oral care composition in the range of 300 to 2000 ppm, preferably about 1450 ppm.

[0068] In addition to the magnesium ion-containing material, the optional remineralizing and / or whitening agent, and the optional fluoride compound, the oral care composition may further include additives typically used in the compositions to be prepared, such as bioadhesive polymers, surfactants, binders, humectants, desensitizing agents, flavoring agents, sweetening agents, and / or water. Such compounds are well known to those skilled in the art.

[0069] According to one embodiment of the present invention, the oral care composition comprises a bioadhesive polymer. The bioadhesive polymer may include any polymer that promotes adhesion of any of the components of the oral care composition to the tooth or tooth surface and remains on the tooth or tooth surface for an extended period of time, for example, 1 hour, 3 hours, 5 hours, 10 hours, or 24 hours. In certain embodiments, the bioadhesive polymer may become more adhesive when the oral care composition is moistened, for example, with water or saliva. In other embodiments, the bioadhesive polymer is a material or combination of materials that improves retention of the active ingredient on the tooth or tooth surface to which the composition is applied. Such bioadhesive polymers include, for example, hydrophilic organic polymers, hydrophobic organic polymers, silicone rubber, silica, and combinations thereof. According to one embodiment, the bioadhesive polymer is selected from the group consisting of hydroxyethyl methacrylate, PEG / PPG copolymer, polyvinyl methyl ether / maleic anhydride copolymer, polyvinylpyrrolidone (PVP), cross-linked PVP, shellac, polyethylene oxide, methacrylate, acrylate copolymer, methacrylic acid copolymer, vinylpyrrolidone / vinyl acetate copolymer, polyvinylcaprolactam, polylactide, silicone resin, silicone adhesive, chitosan, milk protein (casein), amelogenin, ester gum, and combinations thereof.

[0070] Suitable surfactants are generally anionic organic synthetic surfactants over a wide pH range. Representative of such surfactants, used at about 0.5 to 5% by weight based on the total weight of the oral care composition, are C 10 -C 18 Water-soluble salts of alkyl sulfates, such as sodium lauryl sulfate, water-soluble salts of sulfonated monoglycerides of fatty acids, such as sodium monoglyceride sulfonate, water-soluble salts of fatty acid amides of taurine, such as sodium N-methyl-N-palmitoyl tauride, fatty acid esters of isethionic acid, and water-soluble salts of fatty acrylamides, such as sodium N-lauroyl sarcosinate. However, surfactants obtained from natural sources, such as cocamidopropyl betaine, may also be used.

[0071] Suitable binders or thickeners to impart the desired consistency are, for example, hydroxyethyl cellulose, sodium carboxymethyl cellulose, natural gums such as karaya gum, gum arabic, tragacanth gum, xanthan gum, or cellulose gum. Roughly speaking, 0.5 to 5% by weight, based on the total weight of the oral care composition, can be used.

[0072] The desensitizing agent may be selected from the group consisting of potassium nitrate, glutaraldehyde, silver nitrate, zinc chloride, strontium chloride hexahydrate, sodium fluoride, stannous fluoride, strontium chloride, strontium acetate, arginine, hydroxylapatite, sodium calcium phosphosilicate, potassium oxalate, calcium phosphate, calcium carbonate, bioactive glass, and mixtures thereof.

[0073] Various humectants known to those skilled in the art, such as glycerin, sorbitol, and other polyhydric alcohols, can be used, for example, in amounts of 20 to 40% by weight based on the total weight of the oral care composition. Examples of suitable flavoring agents include wintergreen oil, spearmint oil, peppermint oil, clove oil, sassafras oil, and the like. Saccharin, aspartame, glucose, or fructose can be used as sweeteners, for example, in amounts of 0.01 to 1% by weight based on the total weight of the oral care composition. Preservatives, such as sodium benzoate, can be present in amounts of 0.01 to 1% by weight based on the total weight of the oral care composition. Colorants can also be added to the oral care composition in amounts of 0.01 to 1.5% by weight based on the total weight of the oral care composition.

[0074] According to one embodiment of the present invention, the oral care composition is a toothpaste. The toothpaste may be prepared by a process comprising the steps of: (I) providing a mixture of water and one or more humectants, and optionally at least one of a thickening agent, a preservative, a fluoride compound, and a sweetening agent; (II) adding a magnesium ion-containing material in an amount of 0.1 to 40 wt % based on the total weight of the composition, and optionally a colorant, to the mixture of step (I); (III) adding a surfactant to the mixture of step (II); and (IV) optionally adding a flavoring agent to the mixture of step (III).

[0075] However, the toothpaste of the present invention may be prepared by any other method known to those skilled in the art.

[0076] The oral care compositions of the present invention can be used professionally, in office treatments, or in home treatments.

[0077] According to one embodiment, the oral care composition is used in a method comprising administering a therapeutically effective amount of the oral care composition to at least one tooth of a patient at least once daily, preferably twice daily, and more preferably three times daily. A "therapeutically effective" amount of an oral care composition is an amount that, when used in the methods of the invention, is sufficient to exert a desired therapeutic or prophylactic effect in a human subject to which the composition is administered, without undue side effects (e.g., toxicity, irritation, or allergic response), commensurate with a reasonable benefit / risk ratio. The specific effective amount will vary depending on factors such as the specific condition being treated, the physical condition of the subject, the nature of concomitant therapy (if any), the specific dosage form, and the specific oral care composition used.

[0078] According to one embodiment, the oral care composition of the present invention is used in a method comprising applying the composition to at least one tooth of a patient for an amount of time effective to leave the composition on the at least one tooth, preferably for at least 1 minute, at least 15 minutes, at least 30 minutes, at least 1 hour, at least 2 hours, at least 12 hours, or at least 24 hours.

[0079] According to a preferred embodiment of the present invention, the oral care composition does not contain an oxidative whitening compound.

[0080] use It has been found that magnesium ion-containing materials according to the present invention can be used as opacifying and / or whitening pigments in oral care compositions.

[0081] In accordance with one embodiment of the present invention, there is provided a magnesium ion-containing material that can be used as an opacifying agent in oral care compositions.

[0082] In accordance with another embodiment of the present invention, there is provided a magnesium ion-containing material that can be used as a whitening agent in oral care compositions.

[0083] In accordance with another embodiment of the present invention, there is provided a magnesium ion-containing material that can be used as an opacifying and whitening agent in oral care compositions.

[0084] With regard to the definitions of magnesium ion-containing material, oral care composition, and preferably preferred embodiments thereof, reference is made to what has been said above when discussing the technical details of the oral care composition of the present invention.

[0085] It is recognized that magnesium ion-containing materials can be used as whitening pigments and are therefore intended to impart whiteness to oral care compositions, i.e., they do not whiten teeth.

[0086] It has surprisingly been found by the inventors that magnesium ion-containing materials also provide a high availability of fluoride ions in oral care compositions, particularly compared to compositions containing calcium carbonate.

[0087] The scope and benefits of this invention will be better understood based on the following examples, which are intended to illustrate certain specific embodiments of the invention and are non-limiting. [Example]

[0088] 1.Measurement method The measurement methods used in the examples are explained below.

[0089] Particle size distribution Volume-determined median particle size d 50 (vol) and volume-determined top cut particle size d 98 (vol) was assessed using a Malvern Mastersizer 3000 Laser Diffraction System equipped with a Hydro LV system (Malvern Instruments Plc., Great Britain). 50 (vol) or d 98 The (vol) values ​​indicate the diameter values ​​where 50% or 98% by volume of the particles, respectively, have a diameter less than this value. The powder was suspended in a 0.1 wt% Na4O7P2 solution. 10 mL of 0.1 wt% Na4O7P2 was added to the Hydro LV tank, and then the sample slurry was introduced until 10-20% darkening was achieved. Measurements were taken with red and blue light for 10 seconds each. For analysis of the raw data, a model for non-spherical particle size using Mie theory was used, with a particle refractive index of 1.57 and a density of 2.70 g / cm3. 3 The absorption coefficient was taken to be 0.005. This method and instrument are known to those skilled in the art and are commonly used to determine particle size distributions of fillers and pigments.

[0090] Specific surface area (SSA) The specific surface area was measured via the BET method according to ISO 9277:2010 using nitrogen as the adsorption gas on a Micromeritics ASAP 2460 instrument from Micromeritics. The samples were vacuum (10°C) by heating at 150°C for 60 minutes before the measurement. -5 It was pretreated with bar.

[0091] CIELAB L for particulate materials * CIELAB L for magnesium ion-containing materials and other particulate materials *was measured dry according to EN ISO 11664 4:2010.

[0092] Fluoride Availability Toothpastes were freshly prepared as oral care compositions and aged overnight (14 hours) to establish a short-term equilibrium of fluoride concentration (i.e., fluoride availability) for each composition. Extraction was performed by diluting the toothpaste with 10 volumes of demineralized water in a glass beaker (typically 3-5 g of toothpaste diluted with 30-50 g of water), followed by vigorous stirring at 800 rpm for 1 hour and filtering through a syringe filter (Chromafil Xtra, RC-20 / 25 0.2 μm). Fluoride availability was determined after a 100-fold volumetric dilution (with an Eppendorf Research Plus micropipette) using a cuvette test (Hach-Lange LCK 323, 0.1-2.5 ppm fluoride) in a Hach-Lange DR6000 spectrophotometer. Weighted amounts were recorded for all dilutions, and these values ​​were used to calculate the effective (free) fluoride concentration (i.e., fluoride availability) in the original formula. The percentage of extractable fluoride was reported relative to a benchmark test using untreated (base formula) toothpaste, which was performed for each series of experiments. The results obtained with untreated toothpaste were multiplied by 0.98 to account for the dilution of the toothpaste due to the addition of the corresponding particulate material (substrate). Some samples were added as filter cakes with solids contents ranging from 10 to 85% by weight, and the resulting dilution was taken into account in calculating fluoride availability.

[0093] Whiteness of Oral Care Compositions / CIELAB L * The corresponding toothpaste was transferred to a PTFE sample holder and subsequently covered with a glass plate to obtain a reproducible flat surface. The samples were evaluated in a Datacolor ELREPHO spectrophotometer using barium sulfate as a reference material. The reported values ​​for whiteness are based on the L of the CIELAB color space according to EN ISO 11664 4:2010. * The brightness value.

[0094] Opacity of Oral Care Compositions The corresponding toothpaste was diluted with 15% by weight of demineralized water and mixed for 20 seconds at 2760 rpm in a speed mixer (Hauschild DAC 150.1 FVZ). A 300 μm layer was then spread onto a Leneta Opacity Chart (Form 3B-H) using a TQC AFA Compact automatic film applicator at 23 mm / s. The film was immediately covered with a transparent plastic sheet to prevent drying. The R per area was measured on a Datacolor 800V spectrophotometer using barium sulfate as a reference. y The contrast value (R y,黒 / R y,白 * 100) was calculated.

[0095] 2. Materials used The particulate materials shown in Table 1 were used as substrates for the present invention.

[0096] [Table 1]

[0097] The characteristics of the substrate are shown in Table 2 below. [Table 2]

[0098] An IKA ULTRA TURRAX® disperser was used to prepare the toothpaste base formulation. The ingredients in the toothpaste base formulation are listed in Table 3 below. The formulation was prepared at a total mass of 1 kg. In a beaker, sorbitol, sodium fluoride, sodium saccharin, sodium benzoate, propylene glycol, glycerin, and cellulose gum were vigorously mixed. Following this, water was added, and the mixture was further stirred until a uniform texture was obtained. Sorbosil AC35 was then added stepwise with vigorous stirring, and further stirred until a uniform texture was obtained. Sorbosil TC15 was then added stepwise with vigorous stirring, and further stirred until a uniform texture was obtained, thereby obtaining the toothpaste base formulation. Two masterbatches of toothpaste were prepared based on different batches of raw materials. To compensate for the resulting differences (especially in optical properties), these are identified as Batch 1 (#B1) and Batch 2 (#B2).

[0099] [Table 3]

[0100] The final toothpaste was prepared in a plastic container by adding the desired amount of the corresponding base material (0.25-2 g) to 25-30 g of toothpaste base formula. The formulation was manually mixed using a spatula, followed by homogenization using a speed mixer (Hauschild DAC 150.1 FVZ) at 2760 rpm for 20 seconds or a Polytron GT 10-35 PT disperser equipped with a PT-DA 30 / 2EC-F250 to disperse aggregates. The desired amount of surfactant (I11, according to the formulation of the base formula in Table 3) was then added using an Eppendorf Research Plus micropipette, and the formulation was manually mixed using a spatula. Finally, the desired amount of flavor (I12, according to the formulation of the base formula in Table 3) was added using an Eppendorf Research Plus micropipette, and the formulation was manually mixed using a spatula.

[0101] 3.Results The prepared toothpastes were evaluated for fluoride availability, whiteness, and opacity, and the results are shown in Table 4 below.

[0102] [Table 4]

[0103] These results show that the material according to the invention provides high fluoride availability in combination with high whiteness and opacity. The following are examples of embodiments of the present invention. <Aspect 1> 1. An oral care composition comprising a magnesium ion-containing material in an amount of 0.1 to 40 wt. %, based on the total weight of the composition, The magnesium ion-containing material has a volume median particle size (d 50 ) and anhydrous magnesium carbonate or magnesite (MgCO 3 ), hydromagnesite (Mg 5 (CO 3 ) 4 (OH) 2 ·4H 2 O), Artinite (Mg 2 (CO 3 )(OH) 2 ·3H 2 O), Dipingite (Mg 5 (CO 3 ) 4 (OH) 2 ·5H 2 O), georgiosite (Mg 5 (CO 3 ) 4 (OH) 2 ·5H 2 O), Pokrovskite (Mg 2 (CO 3 )(OH) 2 ·0.5H 2 O), barlintonite (MgCO 3 ·2H 2 O), Lansfordite (MgCO 3 ·5H 2 O), nesquehonite (MgCO 3 ·3H 2 O), brucite (Mg(OH) 2 ), dolomite (CaMg(CO 3 ) 2 ), diisopropyl alcohol, ... Oral care compositions. <Aspect 2> The magnesium ion-containing material is anhydrous magnesium carbonate or magnesite (MgCO 3 ), dolomite (CaMg(CO 3 ) 2 ), hydromagnesite (Mg 5 (CO 3 ) 4 (OH) 2 ·4H 2 O), brucite (Mg(OH) 2 2. The oral care composition of claim 1, wherein the oral care composition is selected from the group consisting of: <Aspect 3> 3. The oral care composition of any one of the preceding claims, wherein the magnesium ion-containing material is in the form of particles having: (a) A volume median particle size (d) of 0.2 to 15 μm, more preferably 0.5 to 10 μm, and most preferably 1 to 5 μm, as determined by laser diffraction 50 ), and / or (b) a volume-determined top-cut particle size (d) of 30 μm or less, preferably 2 to 30 μm, more preferably 5 to 20 μm, and most preferably 8 to 18 μm, as determined by laser diffraction 98 )。 <Aspect 4> The magnesium ion-containing material has a CIELAB L of >90%, preferably >95%, more preferably >98%, and most preferably >98.5%, measured dry according to EN ISO 11664 4:2010. * The oral care composition according to any one of aspects 1 to 3, having a whiteness determined as follows: <Aspect 5> The magnesium ion-containing material has a viscosity of 2 to 200 m as measured using nitrogen and the BET method according to ISO 9277:2010. 2 / g, preferably 10 to 100m 2 / g, most preferably 12 to 75 m 2 5. The oral care composition of any one of aspects 1 to 4, in the form of particles having a BET specific surface area of ​​1 / g. <Aspect 6> 6. The oral care composition of any one of Aspects 1-5, wherein the oral care composition further comprises a fluoride compound, preferably the fluoride compound is selected from the group consisting of sodium fluoride, stannous fluoride, sodium monofluorophosphate, potassium fluoride, potassium stannous fluoride, sodium fluorostannate, stannous chloride fluoride, amine fluorides, and mixtures thereof, more preferably the fluoride compound is sodium monofluorophosphate and / or sodium fluoride. <Aspect 7> 7. The oral care composition of any one of aspects 1 to 6, wherein the oral care composition further comprises a remineralizing and / or whitening agent, preferably selected from the group consisting of silica; hydroxylapatite, such as nanohydroxylapatite; calcium carbonate, such as amorphous calcium carbonate, ground calcium carbonate, precipitated calcium carbonate, surface-reacted calcium carbonate, and combinations thereof; calcium silicate; and mixtures thereof. <Aspect 8> 8. The oral care composition according to any one of the preceding aspects, wherein the oral care composition is a toothpaste, tooth gel, tooth powder, varnish, adhesive gel, cement, resin, spray, foam, balm, a composition embodied in a mouth strip or buccal adhesive patch, a chewable tablet, a chewable troche, a chewable gum, a lozenge, a beverage, or a mouthwash, preferably a chewable gum, lozenge, toothpaste, tooth powder, or mouthwash, and most preferably a toothpaste. <Aspect 9> 9. The oral care composition of any one of aspects 1 to 8, having a pH of 6.8 to 10, preferably 7.5 to 9, most preferably 8 to 9. <Aspect 10> 10. The oral care composition of any one of Aspects 1 to 9, comprising the magnesium ion-containing material in an amount of 0.5 to 10% by weight, based on the total weight of the composition. <Aspect 11> 1. Use of a magnesium ion-containing material as an opacifying agent and / or whitening pigment in an oral care composition, comprising: The magnesium ion-containing material has a volume median particle size (d 50 ) and anhydrous magnesium carbonate or magnesite (MgCO 3 ), hydromagnesite (Mg 5 (CO 3 ) 4 (OH) 2 ·4H 2 O), Artinite (Mg 2 (CO 3 )(OH) 2 ·3H 2 O), Dipingite (Mg 5 (CO 3 ) 4 (OH) 2 ·5H 2 O), georgiosite (Mg 5 (CO 3 ) 4 (OH) 2 ·5H 2 O), Pokrovskite (Mg 2 (CO 3 )(OH) 2 ·0.5H 2 O), barlintonite (MgCO 3 ·2H 2 O), Lansfordite (MgCO 3 ·5H 2 O), nesquehonite (MgCO 3 ·3H 2 O), brucite (Mg(OH) 2 ), dolomite (CaMg(CO 3 ) 2 ), diisopropyl alcohol, ... use. <Aspect 12> The magnesium ion-containing material is anhydrous magnesium carbonate or magnesite (MgCO 3 ), dolomite (CaMg(CO 3 ) 2 ), hydromagnesite (Mg 5 (CO 3 ) 4 (OH) 2 ·4H 2 O), brucite (Mg(OH) 2 12. The use according to embodiment 11, wherein the hydroxybenzoate is selected from the group consisting of hydroxybenzoates, ... <Aspect 13> Use according to aspect 11 or 12, wherein the magnesium ion-containing material is in the form of particles having: (a) A volume median particle size (d) of 0.2 to 15 μm, more preferably 0.5 to 10 μm, and most preferably 1 to 5 μm, as determined by laser diffraction 50 ), and / or (b) a volume-determined top-cut particle size (d) of 30 μm or less, preferably 2 to 30 μm, more preferably 5 to 20 μm, and most preferably 8 to 18 μm, as determined by laser diffraction 98 ), and / or (c) Nitrogen and 2-200 m measured using the BET method according to ISO 9277:2010 2 / g, preferably 10 to 100m 2 / g, most preferably 12 to 75 m 2 / g BET specific surface area.

Claims

1. 1. An oral care composition comprising a magnesium ion-containing material in an amount of 0.1 to 40 wt. %, based on the total weight of the composition, The magnesium ion-containing material has a volume median particle size (d ５０ ) and anhydrous magnesium carbonate or magnesite (MgCO ３ ), hydromagnesite (Mg ５ (CO ３ ) ４ (OH) ２ ・4H ２ O), Artinite (Mg ２ (CO ３ ) (OH) ２ ・3H ２ O), daipingite (Mg ５ (CO ３ ) ４ (OH) ２ ・5H ２ O), georgiosite (Mg ５ (CO ３ ) ４ (OH) ２ ・5H ２ O), Pokrovskite (Mg ２ (CO ３ ) (OH) ２ ・0.5H ２ O), barlintonite (MgCO ３ ・2H ２ O), Lansfordite (MgCO ３ ・5H ２ O), nesquehonite (MgCO ３ ・3H ２ O), brucite (Mg(OH) ２ ), dolomite (CaMg(CO ３ ) ２ ), dihydrocarbonate, and mixtures thereof; the oral care composition further comprises a fluoride compound; and The dorocarbonate is a composite material comprising magnesium mineral and calcium carbonate aggregated at the primary particle level. Oral care compositions.

2. The magnesium ion-containing material is anhydrous magnesium carbonate or magnesite (MgCO ３ ), dolomite (CaMg(CO ３ ) ２ ), hydromagnesite (Mg ５ (CO ３ ) ４ (OH) ２ ・4H ２ O), brucite (Mg(OH) ２ 10. The oral care composition of claim 1, wherein the oral care composition is selected from the group consisting of benzoyl perfluorooctanoate, ...

3. 3. The oral care composition of claim 1 or 2, wherein the magnesium ion-containing material is in the form of particles having: (a) Median particle size by volume (d) of 0.2 to 15 μm determined by laser diffraction ５０ ), and / or (b) Volume-determined top-cut particle size (d ９８ ).

4. The magnesium ion-containing material has a CIELAB L of >90%, measured dry according to EN ISO 11664 4:2010 ＊ The oral care composition according to any one of claims 1 to 3, having a whiteness determined as follows:

5. The magnesium ion-containing material has a viscosity of 2 to 200 m as measured using nitrogen and the BET method according to ISO 9277:2010. ２ 5. The oral care composition according to claim 1, in the form of particles having a BET specific surface area of ​​1 / g.

6. An oral care composition described in any one of claims 1 to 5, wherein the fluoride compound is selected from the group consisting of sodium fluoride, stannous fluoride, sodium monofluorophosphate, potassium fluoride, potassium stannous fluoride, sodium fluorostannate, stannous chloride fluoride, amine fluoride, and mixtures thereof.

7. An oral care composition according to any one of claims 1 to 6, wherein the oral care composition further comprises a remineralising agent and / or a whitening agent.

8. 8. The oral care composition of any one of claims 1 to 7, wherein the oral care composition is a toothpaste, tooth gel, tooth powder, varnish, adhesive gel, cement, resin, spray, foam, balm, a composition embodied in a mouth strip or buccal adhesive patch, a chewable tablet, a chewable troche, a chewable gum, a lozenge, a beverage, or a mouthwash.

9. 9. The oral care composition of any one of claims 1 to 8, having a pH of 6.8 to 10.

10. 10. An oral care composition according to any one of claims 1 to 9, comprising the magnesium ion-containing material in an amount of 0.5 to 10% by weight, based on the total weight of the composition.

11. 1. Use of a magnesium ion-containing material as an opacifying agent and / or whitening pigment in an oral care composition, comprising: The magnesium ion-containing material has a volume median particle size (d ５０ ) and anhydrous magnesium carbonate or magnesite (MgCO ３ ), hydromagnesite (Mg ５ (CO ３ ) ４ (OH) ２ ・4H ２ O), Artinite (Mg ２ (CO ３ ) (OH) ２ ・3H ２ O), daipingite (Mg ５ (CO ３ ) ４ (OH) ２ ・5H ２ O), georgiosite (Mg ５ (CO ３ ) ４ (OH) ２ ・5H ２ O), Pokrovskite (Mg ２ (CO ３ ) (OH) ２ ・0.5H ２ O), barlintonite (MgCO ３ ・2H ２ O), Lansfordite (MgCO ３ ・5H ２ O), nesquehonite (MgCO ３ ・3H ２ O), brucite (Mg(OH) ２ ), dolomite (CaMg(CO ３ ) ２ ), dihydrocarbonate, and mixtures thereof; the oral care composition further comprises a fluoride compound; and The dorocarbonate is a composite material comprising magnesium mineral and calcium carbonate aggregated at the primary particle level. use.

12. The magnesium ion-containing material is anhydrous magnesium carbonate or magnesite (MgCO ３ ), dolomite (CaMg(CO ３ ) ２ ), hydromagnesite (Mg ５ (CO ３ ) ４ (OH) ２ ・4H ２ O), brucite (Mg(OH) ２ 12. The use according to claim 11, wherein the compound is selected from the group consisting of benzophenone, benzophen

13. 13. The use according to claim 11 or 12, wherein the magnesium ion-containing material is in the form of particles having: (a) Median particle size by volume (d) of 0.2 to 15 μm determined by laser diffraction ５０ ), and / or (b) Volume-determined top-cut particle size (d ９８ ), and / or (c) 2-200 m measured using nitrogen and the BET method according to ISO 9277:2010 ２ / g BET specific surface area.

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