Iron compound-containing composition

Abstract

To suppress the formation of precipitates as much as possible from the viewpoint of commerciality such as appearance and a good feel on the tongue, since we have found that a precipitate is formed when a plant placenta extract is added to an oral liquid composition.SOLUTION: As a result of diligent studies to solve this problem, the present inventors have found that the formation of precipitates can be suppressed by blending an iron compound of 0.006 w / v% or more in terms of iron, and a collagen peptide, and completed the present invention. That is, it is an oral liquid composition containing a plant placenta extract, an iron compound, and a collagen peptide, and the content of the iron compound is 0.006 to 0.2 w / v% in terms of iron.SELECTED DRAWING: None

Description

[Technical Field]

[0001] The present invention relates to an oral liquid composition containing a plant placenta extract, which can be used in the fields of pharmaceuticals, quasi-drugs, foods, etc. [Background technology]

[0002] Although iron is an essential metal for living organisms, it has been reported that iron intake, especially in women, tends to be insufficient compared to the recommended intake. The Dietary Reference Intakes for Japanese (2020 edition) recommends 10.5 mg of iron for women, but the 2018 National Health and Nutrition Survey found that women's iron intake was 7.5 mg, resulting in a daily iron deficiency of approximately 3 mg (Non-Patent Document 1). Drinks and supplements containing iron compounds are used as an efficient dietary intake method, but iron compounds react with other ingredients, impairing flavor and quality (Patent Documents 1 and 2). In recent years, beauty drinks containing placenta extract have become increasingly popular. Animal placenta extract, made from mammalian placenta, is an extract extracted from the placenta of mammals such as pigs, cows, horses, humans, or sheep. Mammalian placental tissue is rich in amino acids, active peptides, vitamins, minerals, sugars, enzymes, nucleic acids, and other nutrients essential for fetal growth (Patent Document 3). Because animal placenta extract has a unique taste and odor, masking techniques have been reported for its consumption as a beverage (Patent Document 4).

[0003] In recent years, however, the term placenta has come to be used to refer to materials with similar functions and nutrients to the placenta, such as plant placenta extract, which is made from plant placenta, which is rich in nutrients for seed germination, such as amino acids, vitamins, and minerals (Patent Document 5).

[0004] Although there are several oral liquid compositions containing plant placenta on the market, there is still room for development. [Prior art documents] [Patent documents]

[0005] [Non-Patent Document 1] Food and Development Vol.55 No.6 P.41 [Patent Document 1] Japanese Patent Application Laid-Open No. 2017-93397 [Patent Document 2] Japanese Patent Application Laid-Open No. 2000-279143 [Patent Document 3] Japanese Patent Application Laid-Open No. 2011-160742 [Patent Document 4] Japanese Patent Application Publication No. 2018-166443 [Patent Document 5] Japanese Patent Application Laid-Open No. 2014-224081 Summary of the Invention [Problem to be solved by the invention]

[0006] The present inventors have discovered that when a plant placenta extract is incorporated into an oral liquid composition, a precipitate forms. From the viewpoint of commercial viability, such as appearance and texture, the formation of the precipitate should be suppressed as much as possible. However, no method has been reported to date for suppressing the formation of precipitate derived from the plant placenta extract when incorporated into an oral liquid composition.

[0007] An object of the present invention is to provide an oral liquid composition that inhibits the formation of precipitates derived from plant placenta extract. [Means for solving the problem]

[0008] The inventors of the present invention conducted extensive research to solve this problem and unexpectedly discovered that the formation of precipitates can be suppressed by incorporating an iron compound in an amount of 0.006 w / v% or more in terms of iron, and by incorporating collagen peptides, which led to the completion of the present invention.

[0009] The present invention has been made based on these findings and has the following aspects. (1) An oral liquid composition containing a plant placenta extract, an iron compound, and a collagen peptide, wherein the content of the iron compound is 0.006 to 0.2 w / v% in terms of iron; (2) The oral liquid composition according to (1), wherein the iron compound is at least one selected from the group consisting of ferrous fumarate, ferric chloride, iron citrate, ammonium ferrous citrate, sodium ferrous citrate, ferrous gluconate, iron lactate, ferrous pyrophosphate, ferric pyrophosphate, ferrous sulfate, and heme iron. (3) The oral liquid composition according to (1) or (2), wherein the content of the plant placenta extract is 0.001 to 4 w / v%. (4) The oral liquid composition according to any one of (1) to (3), wherein the content of the plant placenta extract is 0.008 to 32 w / v% in terms of placenta. (5) The oral liquid composition according to any one of (1) to (4), wherein the content of collagen peptide is 0.02 to 20 w / v%. (6) The oral liquid composition according to any one of (1) to (5), having a pH of 2.5 to 4.5. (7) The oral liquid composition according to any one of (1) to (6), wherein the oral liquid composition is a liquid beverage. (8) A method of suppressing precipitation caused by incorporating plant placenta extract by incorporating an iron compound and a collagen peptide. is. [Effects of the Invention]

[0010] According to the present invention, it is possible to provide an oral liquid composition which contains a plant placenta extract and in which precipitation is suppressed. DETAILED DESCRIPTION OF THE INVENTION

[0011] The plant placenta of the present invention is the part inside the ovary of a plant that contains ovules, and its origin is not particularly limited, but examples include rose, morning glory, lotus, camellia, soybean, barley, rye, corn, okra, cucumber, tomato, watermelon, acerola, aloe, melon, chili pepper, bitter melon, etc., with melon being preferred. The plant placenta extract of the present invention can be extracted with a solvent such as water, lower aliphatic alcohols (e.g., methanol, ethanol, isopropyl alcohol), polyhydric alcohols (e.g., 1,3-butylene glycol, propylene glycol, dipropylene glycol, glycerin), or lower aliphatic ketones (e.g., acetone), or a mixture of these solvents, and the form of the extract is not particularly limited. Furthermore, commercially available products such as "Rose Placenta" (Ginza Tomato Co., Ltd.) and "Plant Placenta (Melon Placenta)" (Koei Kogyo Co., Ltd.) may also be used as the plant placenta extract.

[0012] The content of the plant placenta extract of the present invention in the oral liquid composition of the present invention is preferably 0.001 to 4 w / v%, more preferably 0.02 to 2 w / v%, and is preferably 0.008 to 32 w / v%, more preferably 0.16 to 16 w / v%, calculated as placenta.

[0013] Furthermore, in terms of the effects of the present invention, the content of the plant placenta extract is preferably 0.1 to 1000 parts by mass, more preferably 2 to 200 parts by mass, per part by mass of iron, calculated as iron.

[0014] In the present invention, examples of the "iron compound" include ferrous fumarate, ferric chloride, iron citrate, ammonium iron citrate, sodium ferrous citrate, ferrous gluconate, iron lactate, ferrous pyrophosphate, ferric pyrophosphate, ferrous sulfate, and heme iron.

[0015] In terms of the effects of the present invention, the content of the iron compound in the oral liquid composition is preferably 0.006 to 0.2 w / v%, more preferably 0.006 to 0.04 w / v%, calculated as iron, and is preferably 0.03 to 2.0 w / v%, more preferably 0.03 to 1.2 w / v%, even more preferably 0.03 to 0.5 w / v%, and most preferably 0.03 to 0.3 w / v%.

[0016] In the present invention, the origin of the "collagen peptide" is not particularly limited, and it may be synthetic, or may be collagen peptide produced by extraction from hides, bones, ligaments, tendons, cartilage, etc., which are by-products produced when processing livestock such as cows and pigs or fish, but collagen peptides derived from pigs are preferred. Collagen peptides obtained by decomposing collagen protein using enzymes or chemical treatments are preferred. The average molecular weight of the collagen peptide is not particularly limited, but is preferably 500 to 50,000, and more preferably 1,000 to 25,000. The collagen peptide of the present invention may be a commercially available product, such as "Nippi Peptide PS-1" (manufactured by Nippi Co., Ltd.), "Nippi Peptide PRA-P" (manufactured by Nippi Co., Ltd.), "Nippi Peptide FCP-EX" (manufactured by Nippi Co., Ltd.), "HACP-CF" (manufactured by Jellice Co., Ltd.), "HACP-TF" (manufactured by Jellice Co., Ltd.), "Collapep PU" (manufactured by Nitta Gelatin Co., Ltd.), "Collapep JB" (manufactured by Nitta Gelatin Co., Ltd.), "HDL-50SP" (manufactured by Nitta Gelatin Co., Ltd.), "SCP-3100" (manufactured by Nitta Gelatin Co., Ltd.), and "peptan P2000HD" (manufactured by Rousselot Co., Ltd.).

[0017] The content of collagen peptide in the oral liquid composition of the present invention is preferably 0.02 to 20 w / v %, more preferably 0.2 to 15 w / v %.

[0018] In terms of the effects of the present invention, the content of collagen peptide, in iron equivalent, is preferably 0.1 to 4000 parts by mass per 1 part by mass of iron, more preferably 0.5 to 4000 parts by mass, even more preferably 5 to 1500 parts by mass, and most preferably 20 to 1500 parts by mass.

[0019] The present invention can suppress the formation of precipitates derived from plant placenta extract by combining an iron compound with a collagen peptide.

[0020] The oral liquid composition of the present invention is not particularly limited as long as it is a liquid that can be taken orally, and examples thereof include pharmaceuticals, quasi-drugs, and foods (including not only general foods but also foods with nutrient functions and foods for specified health uses). Examples of pharmaceuticals and quasi-drugs include oral liquid preparations and energy drinks. Examples of foods include soft drinks, carbonated drinks, sports and functional drinks, non-alcoholic drinks, milk drinks, tea drinks, coffee drinks, fruit and vegetable drinks, jelly drinks, and the like. More preferred pharmaceuticals and quasi-drugs include oral liquid preparations and energy drinks, and more preferred foods include foods with nutrient functions and foods for specified health uses, as well as carbonated drinks and jelly drinks.

[0021] The pH of the oral liquid composition of the present invention is not particularly limited, but is preferably 2.5 to 4.5, more preferably 3.0 to 4.0, from the viewpoint of palatability. In order to maintain the pH within the above range, a pH adjuster such as an organic acid can be added as needed.

[0022] The oral liquid composition of the present invention can be produced by a conventional method, and the method is not particularly limited. Usually, each ingredient is weighed out, dissolved in an appropriate amount of purified water, stirred, and then the pH is adjusted. The volume is adjusted by adding purified water, and filtering and sterilizing the solution as necessary. Obtained.

[0023] The oral liquid composition of the present invention may further contain other ingredients such as vitamins, minerals, amino acids and their salts, herbal medicines, herbal extracts, caffeine, royal jelly, dextrin, etc., as appropriate, provided that the effects of the present invention are not impaired. Furthermore, if necessary, additives such as antioxidants, colorants, flavorings, corrigents, preservatives, sweeteners, and acidulants may also be added as appropriate, provided that the effects of the present invention are not impaired. [Example]

[0024] The present invention will be described in more detail below with reference to examples and comparative examples.

[0025] (Comparative Example 1, Example 1, Comparative Example 2-2, Examples 2-1, 2-2, Comparative Example 3, Example 3, Comparative Example 5, Example 5) First, citric acid and sodium benzoate were dissolved in purified water, and the volume was adjusted to approximately 60% of the total volume with purified water to obtain an acidulant solution. Next, ferrous ammonium citrate was dissolved in purified water, and the volume was adjusted to 0.4% iron to obtain an iron solution. To the acidulant solution, iron solution or an iron compound was added as needed to obtain the formulation shown in the table. Melon placenta-derived plant placenta extract (Plant Placenta (Melon Placenta), Water Extract, manufactured by Koei Kogyo Co., Ltd.) and porcine-derived collagen peptide (Collapep JB, manufactured by Nitta Gelatin Co., Ltd.) were added, and purified water was added to approximately 90% of the total volume and thoroughly stirred. After thorough stirring, the pH was adjusted with hydrochloric acid or sodium hydroxide, and purified water was added to the total volume to obtain an oral liquid composition. 50 ml of these oral liquid compositions were filled into screw tubes No. 7 (manufactured by Maruemu Co., Ltd.) and sterilized at 80°C for 25 minutes. An oral liquid composition without added ferrous ammonium citrate and collagen peptide served as a control.

[0026] (Comparative Example 2-1, Example 2-3, Comparative Example 3, Comparative Example 4, Examples 4-1 to 4-7) First, citric acid and sodium benzoate were dissolved in purified water, and the volume was adjusted to approximately 60% of the total volume with purified water to obtain an acidulant solution. Next, ferric ammonium citrate was dissolved in purified water, and the volume was adjusted to 0.4% iron content to obtain an iron solution. Furthermore, citric acid, sodium benzoate, and porcine collagen peptide (Collapep JB, manufactured by Nitta Gelatin Co., Ltd.) were dissolved in purified water to obtain a collagen solution. Melon placenta-derived plant placenta extract (Plant Placenta (Melon Placenta), Water Extract, manufactured by Koei Kogyo Co., Ltd.) was weighed into a beaker, and acidulant solution, collagen solution, iron solution or iron compound, and collagen peptide were added as needed to obtain the formulation shown in the table. Purified water was added to approximately 90% of the total volume and thoroughly stirred. After thorough stirring, the pH was adjusted using hydrochloric acid or sodium hydroxide, and purified water was added to the total volume to obtain an oral liquid composition. 50 ml of each of these oral liquid compositions was filled into screw tube No. 7 (manufactured by Maruemu Co., Ltd.) and sterilized for 25 minutes at 80° C. An oral liquid composition without added ammonium iron citrate and collagen peptide served as a control. In Example 4-6, sodium ferrous citrate was added instead of ammonium iron citrate, and in Example 4-7, fish-derived collagen peptide (Nippipeptide FCP-EX, manufactured by Nippi Corporation) was added instead of pig-derived collagen peptide (Collapep JB, manufactured by Nitta Gelatin Co., Ltd.). In addition, according to the manufacturer's information (raw material investigation document), the amount of raw placenta in plant placenta extract is 8 times, and this is calculated as 8 mg of placenta per 1 mg of extract, as shown in the table. The oral liquid compositions prepared as described above were stored at 65°C for 7 days, and the degree of precipitation was visually observed. The degree of precipitation was evaluated according to the criteria in Table 3.

[0027] [Table 1]

[0028] [Table 2]

[0029] [Table 3]

[0030] As shown in Table 1, the incorporation of plant placenta extract caused precipitation, and the rate of precipitation increased as the concentration of plant placenta extract increased (Comparative Examples 1, 2-1, and 3). On the other hand, the incorporation of 0.006 w / v% or more of iron compound in terms of iron and the incorporation of collagen peptide suppressed precipitation (Examples 1 to 3). Furthermore, the precipitation suppression effect increased as the amount of iron compound increased (Examples 2-1 to 2-3). As shown in Table 2, even at pH 4.0, precipitation occurred when plant placenta extract was added (Comparative Example 4), and the rate of precipitation increased as the concentration of plant placenta extract increased (Comparative Examples 4 and 5). However, precipitation was suppressed when an iron compound and collagen peptide were added (Examples 4-1 to 4-5). Furthermore, the effect was greater with increasing amounts of iron compound (Examples 4-1 to 4-3). [Industrial Applicability]

[0031] The present invention makes it possible to inhibit precipitation derived from plant placenta extract in oral liquid compositions, and is therefore expected to provide oral liquid compositions containing plant placenta extract that are highly marketable in the fields of pharmaceuticals, quasi-drugs, and foods.

Claims

1. An oral liquid composition comprising a plant placenta extract, an iron compound, and a collagen peptide, wherein the content of the iron compound is 0.006 to 0.2 w / v % in terms of iron.

2. 2. The oral liquid composition according to claim 1, wherein the iron compound is at least one selected from the group consisting of ferrous fumarate, ferric chloride, iron citrate, ammonium ferrous citrate, sodium ferrous citrate, ferrous gluconate, iron lactate, ferrous pyrophosphate, ferric pyrophosphate, ferrous sulfate, and heme iron.

3. 3. The oral liquid composition according to claim 1, wherein the content of the plant placenta extract is 0.001 to 4 w / v %.

4. 4. The oral liquid composition according to claim 1, wherein the content of the plant placenta extract is 0.008 to 32 w / v % in terms of placenta.

5. 5. The oral liquid composition according to claim 1, wherein the collagen peptide content is 0.02 to 20 w / v %.

6. The oral liquid composition according to any one of claims 1 to 5, having a pH of 2.5 to 4.

5.

7. 7. The oral liquid composition according to claim 1, which is a liquid beverage.

8. A method for suppressing precipitation caused by incorporating plant placenta extract by incorporating an iron compound and collagen peptide.

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