Lip product adhesion inhibitor

Abstract

To provide a labial agent attachment inhibitor that inhibits the release of a labial agent from lips and its attachment to a tooth surface or the like.SOLUTION: A labial agent attachment inhibitor contains a component (A) quaternary ammonium salt and / or a component (B) glycyrrhizinic acid or a salt thereof.SELECTED DRAWING: None

Description

[Technical Field]

[0001] The present invention relates to an agent for inhibiting adhesion of lip preparations. [Background technology]

[0002] Lipstick has traditionally been a widely used makeup product, with products available in a variety of colors and glosses. However, when eating or drinking, lipstick can easily adhere to tableware and other surfaces, and can also easily come off the lips, diminishing the cosmetic effect of the lips. It is also known that misaligned teeth or the way lipstick is applied, such as by applying multiple layers, can easily result in lipstick adhering to the teeth, a condition known as "tooth rouge." Similar problems can occur not only with lipstick, but with any product used on the lips (lip products) in general.

[0003] When lipstick adheres to tableware and other surfaces, removing it requires a lot of effort. Furthermore, tooth rouge impairs aesthetics and ruins the overall impression of the face. Therefore, technology to prevent lipstick from adhering or peeling is desired, and products such as lipstick holders and lipstick overcoats that prevent lipstick from peeling from the lips have been developed and sold. For example, Patent Document 1 discloses a lipstick holder sheet that has a sheet body that absorbs lipstick oil and is coated with powder such as mica that adsorbs to the lipstick and prevents it from peeling. Patent Document 2 also discloses a non-emulsified lip overcoat containing a metal soap and / or an acylated amino acid, a polyhydric alcohol, and water. [Prior art documents] [Patent documents]

[0004] [Patent Document 1] Publication number 7-10672 [Patent Document 2] Japanese Patent Application Publication No. 8-183714 Summary of the Invention [Problem to be solved by the invention]

[0005] However, the above-mentioned lipstick holding sheets, lipstick overcoats, and other technologies require the application of a specific agent to the lipstick itself, and their usage patterns are limited. For example, there is no known technology that can prevent lipstick from coming off or from adhering to teeth, dishes, or the like by applying the agent to the object itself where lipstick is expected to adhere, such as the oral cavity or dishes.

[0006] Therefore, an object of the present invention is to provide a new agent for inhibiting adhesion of lip preparations, such as lipstick, which can inhibit the separation of lip preparations such as lipstick and adhesion to tooth surfaces, etc. [Means for solving the problem]

[0007] As a result of extensive research, the present inventors have discovered that by applying at least one of (A) a quaternary ammonium salt and (B) glycyrrhizinic acid or a salt thereof to an object to which adhesion of a lip preparation such as lipstick to the object is to be inhibited, it is possible to inhibit the removal of the lip preparation and the adhesion of the lip preparation to the object, and have thus completed the present invention.

[0008] Therefore, the present invention is based on the discovery of a new use of (A) a quaternary ammonium salt and (B) glycyrrhizinic acid or a salt thereof, namely, inhibiting adhesion of lip preparations, and is achieved by the following (1) and (2). (1) A lip preparation adhesion inhibitor containing at least one of the following components (A) and (B): (A) Quaternary ammonium salt (B) Glycyrrhizic acid or its salt (2) A method for suppressing adhesion of a lip preparation to a target, comprising applying at least one of the following components (A) and (B) to the target: (A) Quaternary ammonium salt (B) Glycyrrhizic acid or its salt [Effects of the Invention]

[0009] The lip preparation adhesion inhibitor of the present invention contains at least one of the components (A) a quaternary ammonium salt and (B) glycyrrhizinic acid or a salt thereof, and is therefore able to inhibit adhesion of the lip preparation to an object to which the inhibitor is applied. [Brief explanation of the drawings]

[0010] [Figure 1] 1 shows the rate of lipstick adhesion to the HA plate when each sample of Examples 1 to 5 and Reference Example 1 was applied in Test Example 1. [Figure 2] 1 shows the rate of lipstick adhesion to the outer bottom of the bottle cap when each sample of Examples 1 to 5 and Reference Example 1 was applied in Test Example 2-1. [Figure 3] 1 is a photograph showing the outside of a bottle cap when each sample of Example 1 and Reference Example 1 is applied in Test Example 2-2. DETAILED DESCRIPTION OF THE INVENTION

[0011] The present invention will now be described in further detail. As used herein, the term "lip preparation" refers to a general agent used on the lips, and includes cosmetics (lip cosmetics) and pharmaceuticals (lip pharmaceuticals) used on the lips. Lip cosmetics include lipstick and gloss, and may be composed of an oily base such as fats, oils, waxes, and waxes, and coloring materials such as dyes and pigments. Lip pharmaceuticals include lip medications for cheilitis, angular cheilitis, herpes labialis, and the like. Lip preparations include, for example, those in the form of sticks, pencils, and ointments.

[0012] The lip preparation adhesion inhibitor of the present invention (hereinafter sometimes referred to as the agent of the present invention) contains at least one of the following components: (A) a quaternary ammonium salt, and (B) glycyrrhizinic acid or a salt thereof. The present invention is based on the discovery that (A) a quaternary ammonium salt, and (B) glycyrrhizinic acid or a salt thereof, can inhibit the adhesion of lip preparations to a target. This is presumably because, by applying a quaternary ammonium salt and glycyrrhizinic acid or a salt thereof to a target to which lip preparation adhesion is to be inhibited, a phase of the above components is formed on the target's surface, inhibiting direct contact with the lip preparation. However, the present invention is not limited to those having the above-mentioned mechanism of action.

[0013] The agent of the present invention can be applied to an object to which adhesion of the lip agent is desired to be inhibited, thereby inhibiting adhesion of the lip agent to the object. For example, when applied to the oral cavity, adhesion of the lip agent to the tooth surface, such as the generation of rouge, can be inhibited. Therefore, the effect of the lip agent can be sustained, and in the case of lip cosmetics such as lipstick, a good impression can be maintained not only around the mouth but also across the face. Furthermore, by applying the agent to an object, such as tableware to which lip agents are likely to adhere, adhesion of the lip agent to the object itself can also be inhibited.

[0014] <Component (A): Quaternary ammonium salt> The (A) quaternary ammonium salt of the present invention refers to a salt of a quaternary ammonium cation and another anion. It is presumed that the quaternary ammonium cation in the (A) quaternary ammonium salt of the present invention is primarily responsible for the function of inhibiting adhesion of lip preparations. Therefore, the type of quaternary ammonium salt is not particularly limited and can be appropriately selected depending on the purpose. Preferred examples include cetylpyridinium chloride, benzethonium chloride, benzalkonium chloride, and hexadecyltrimethylammonium bromide. These may be used alone or in combination of two or more. Among these, cetylpyridinium chloride and benzethonium chloride are particularly preferred due to their high effect of inhibiting adhesion of lip preparations.

[0015] When the agent of the present invention contains a quaternary ammonium salt, the quaternary ammonium salt is contained in an amount of, for example, 0.001% by mass or more, preferably 0.01% by mass or more, and more preferably 0.04% by mass or more, based on the total amount of the agent of the present invention. By containing 0.001% by mass or more of the quaternary ammonium salt, the effect of inhibiting adhesion of the lip agent can be fully exerted. Furthermore, the quaternary ammonium salt is contained in an amount of, for example, 0.5% by mass or less, preferably 0.1% by mass or less, and more preferably 0.06% by mass or less, based on the total amount of the agent of the present invention. By containing 0.5% by mass or less of the quaternary ammonium salt, irritation to the oral mucosa can be suppressed.

[0016] <Component (B): Glycyrrhizic acid or its salt> The (B) glycyrrhizinic acid or its salt in the present invention is a component contained in the roots and stems of licorice, a type of herbal medicine. The type of glycyrrhizinic acid or its salt used in the present invention is not particularly limited and can be appropriately selected depending on the purpose. Examples include glycyrrhizinic acid, dipotassium glycyrrhizinate (GK2), trisodium glycyrrhizinate, monoammonium glycyrrhizinate, diammonium glycyrrhizinate, and disodium glycyrrhizinate. These may be used alone or in combination of two or more. Among these, dipotassium glycyrrhizinate is particularly preferred because of its excellent formulation stability.

[0017] Glycyrrhizic acid or a salt thereof can be obtained by extraction from licorice using a conventionally known method, or commercially available products such as dipotassium glycyrrhizinate and monoammonium glycyrrhizinate manufactured by Alps Pharmaceutical Co., Ltd. or Maruzen Pharmaceutical Co., Ltd. can be used.

[0018] When the agent of the present invention contains glycyrrhizinic acid or a salt thereof, the amount of glycyrrhizinic acid or a salt thereof is, for example, 0.001% by mass or more, preferably 0.005% by mass or more, and more preferably 0.01% by mass or more, based on the total amount of the agent of the present invention. By containing glycyrrhizinic acid or a salt thereof at 0.001% by mass or more, the effect of inhibiting adhesion of lip preparations can be fully exerted. Furthermore, the amount of glycyrrhizinic acid or a salt thereof is, for example, 0.1% by mass or less, preferably 0.05% by mass or less, and more preferably 0.02% by mass or less, based on the total amount of the agent of the present invention. By containing glycyrrhizinic acid or a salt thereof at 0.1% by mass or less, the effect can be exerted without impairing the palatability of the preparation.

[0019] The agent of the present invention contains at least one of (A) a quaternary ammonium salt and (B) glycyrrhizinic acid or a salt thereof, but it preferably contains both components (A) and (B) in order to fully exert the effect of inhibiting adhesion of the lip agent. In this case, the content ratio (by mass) of components (A) and (B) is, for example, 100:1 to 1:10, preferably 50:1 to 1:5, and more preferably 20:1 to 1:1. By keeping the content within the above range, the effect of inhibiting adhesion of the lip agent can be more strongly exerted.

[0020] The agent of the present invention can be in any dosage form depending on its intended use, and examples thereof include liquid, solid, gel, and semi-solid forms such as paste.

[0021] The agent of the present invention can be applied to any object to which adhesion of a lip agent is desired to be inhibited. Examples of targets to which the agent of the present invention is applied include target sites such as oral tissue and skin, as well as objects such as tableware, clothing, and masks. It is particularly preferable to apply the agent to targets to which lip preparations are likely to adhere, such as oral tissue and tableware. When the agent of the present invention is applied to oral tissue, it can, for example, inhibit the adhesion of the lip preparation to tooth surfaces. Furthermore, by applying the agent to targets such as tableware to which lip preparations are likely to adhere, it is possible to inhibit the adhesion of the lip preparation to the target.

[0022] When the agent of the present invention is applied to the oral cavity, it can be made into an oral composition (a composition for inhibiting adhesion of a lip agent to the oral cavity) containing predetermined components other than the above-mentioned components (A) and (B). Specifically, the oral composition can contain various components that can be applied to the oral cavity, as long as they do not deteriorate the feeling of use or impair the effects of the present invention, such as solvents, bactericides, substances with tooth surface strengthening effects, humectants, foaming agents, sweeteners, preservatives, and other components.

[0023] Examples of the solvent include water such as purified water and ionized water, and polyhydric alcohols such as ethanol, propylene glycol, butylene glycol, and polyethylene glycol. From the viewpoint of application to the oral cavity, it is preferable to use a solvent mainly composed of water, and other solvents such as the above-mentioned alcohols may be contained in amounts less than water. For example, the amount of alcohol contained in the solvent is usually 0 to 30% by mass. Furthermore, the amount of water contained in the solvent is, for example, 50 to 98% by mass.

[0024] Examples of disinfectants include triclosan, isopropylmethylphenol, protease, and alkyldiaminoethylglycine hydrochloride.

[0025] Examples of substances that have a tooth surface strengthening effect include fluoride ion sources such as sodium fluoride, fluorophosphates, and fluoroborates, and phosphate ion sources such as calcium phosphate and hydroxyapatite.

[0026] Further examples include humectants such as glycerin and sorbitol, foaming agents such as sodium lauryl sulfate, sweeteners such as stevioside, xylitol, erythritol, sorbitol, sodium saccharin, and sucralose, preservatives such as parahydroxybenzoic acid esters and sodium benzoate, etc. Among these, humectants such as glycerin are effective in promoting the adhesion-inhibiting effect of lip preparations.

[0027] Other examples of surfactants include nonionic surfactants such as polyoxyethylene hydrogenated castor oil, polyoxyethylene-polyoxypropylene block polymers, polyoxyethylene-polyoxypropylene alkyl ethers, polyoxyethylene alkyl ethers, polyoxyethylene alkylphenyl ethers, polyoxyethylene fatty acid esters, polyoxyethylene higher alcohol ethers, polyoxyethylene-polyoxypropylene fatty acid esters, polyoxyethylene sorbitan fatty acid esters, polyoxyethylene sorbitan fatty acid esters, sorbitan fatty acid esters, polyoxyethylene sorbitan monolaurate, glycerin fatty acid esters, polyglycerin fatty acid esters, propylene glycol fatty acid esters, polyoxyethylene cholesteryl ether, and polyoxyethylene phytosterol ether; sodium lauryl sulfate, sodium myristyl sulfate, polyoxyethylene alkyl ether sulfates, sodium lauroyl sarcosinate, sodium myristoyl sarcosinate, alkyl ether carbohydrates; anionic surfactants such as phosphates, alkyl phosphates, polyoxyethylene alkyl ether phosphates, N-acyltaurine salts, polyoxyethylene alkyl ether phosphoric acid / phosphate salts, and sulfonates; pH adjusters such as sodium dihydrogen phosphate, sodium hydrogen phosphate, citric acid, and sodium citrate; fragrances such as peppermint oil, peppermint oil, menthol, carvacrol, eucalyptus oil, eugenol, anethole, and cineole; and Blue No. 1, Yellow No. 4, Red No. 102, and Green No. 201. It may contain pigments such as fixed pigments, lysozyme chloride, dextranase, mutanase, azulene, azulene sulfonate, dihydrocholesterol, epidihydrocholesterol, Phellodendron Bark extract, Angelica acutiloba soft extract, hinokitiol, allantoin, allantoin chlorohydroxyaluminum, sodium chloride, dl-α-tocopherol acetate, dl-α-tocopherol nicotinate, epsilon aminocaproic acid, tranexamic acid, polyphosphates, thymol, copper chlorophyllin sodium, and wax.

[0028] The oral composition can be in the form of mouthwash, liquid toothpaste, mouth freshener, gargle (gargle), toothpaste such as liquid toothpaste and toothpaste, lozenge, chewing gum, and the like. In particular, the composition is preferably used as a mouthwash, in which an appropriate amount is placed in the oral cavity so that the components (A) and (B) are sufficiently distributed throughout the oral cavity. To prepare a mouthwash, for example, water, ethanol, or the like may be used as a solvent, and the mouthwash may be prepared by a conventional method. Furthermore, for example, liquid dentifrices may be used that contain abrasives such as calcium hydrogen phosphate, aluminum hydroxide, silicic anhydride, calcium carbonate, etc., as needed.

[0029] When the agent of the present invention is used as an oral composition, particularly as a mouthwash, it can be used by rinsing the oral cavity for 20 to 30 seconds, allowing the agent of the present invention to be thoroughly distributed throughout the oral cavity and fully exerting the effect of inhibiting adhesion of the lip agent.

[0030] Furthermore, even when the agent of the present invention is applied to any target other than the oral cavity, it can be blended with any other ingredients or prepared into any dosage form according to the characteristics of the target. For example, when the agent of the present invention is a liquid, the target can be immersed in the agent, or the agent can be applied or sprayed. When the agent of the present invention is a semi-solid such as a solid, gel, or paste, the agent can be applied to the target. [Example]

[0031] The present invention will be further described below with reference to examples, but the present invention is not limited to the following examples.

[0032] (Test Example 1) In order to confirm the effect of the agent of the present invention in inhibiting adhesion of lipstick to tooth surfaces, the following test was carried out using a hydroxyapatite plate (hereinafter referred to as HA plate) as a tooth surface model.

[0033] [Sample preparation] Various components were mixed according to the formulations in Table 1 below to prepare the samples of Examples 1 to 5 and Reference Example 1. In Table 1, "-" means that the component in question was not contained.

[0034] [Table 1]

[0035] The various components are described in detail below. Component (A) Cetylpyridinium chloride: Trade name RonaCare® CPC, manufactured by Merck Benzethonium chloride: Trade name Lonzagard Benzethonium Chloride-M (registered trademark), manufactured by Lonza Pharmaceuticals Ingredient (B) Dipotassium glycyrrhizinate: Product name: Dipotassium glycyrrhizinate, manufactured by Alps Pharmaceutical Co., Ltd. Glycerin: Product name: Concentrated Glycerin, manufactured by Sakamoto Pharmaceutical Co., Ltd.

[0036] [Test method] 1. Lipstick (product name: Reddit Creamy Balm Rouge 01 Terracotta Red, manufactured by StylingLife Holdings, Inc.) was applied to the surface of the sponge. 2. An HA plate (10 mm x 10 mm) was fixed to the bottom of the outside of the polypropylene resin cap, and then the HA plate was immersed in each of the above samples for 30 seconds. 3. After immersion in each sample, the HA plate fixed to the bottom of the outside of the cap was pressed against the lipstick-applied area on the sponge with a pressure of about 1N. 4. The lipstick adhesion rate to the HA plate was calculated using the following formula. Lipstick adhesion rate (%) = (lipstick adhesion area value / contact area value) x 100 The lipstick adhesion area value and contact area value were determined as follows. First, the main surface of the HA plate pressed against the lipstick application area on the sponge was photographed. Next, the main surface of the HA plate with an area of ​​100 mm 2The number of pixels (px) in the image (10 mm x 10 mm) was measured using the image processing software "ImageJ." Furthermore, the area (px) of the lipstick attached to the main surface of the HA plate was calculated using the image processing software "ImageJ." The obtained area (px) of the main surface of the HA was designated as the "contact area value" (a), and the lipstick-attached area (px) was designated as the "lipstick-attached area value" (b). "ImageJ" is open source, public domain image processing software developed by the National Institutes of Health (NIH).

[0037] Table 2 and FIG. 1 show the lipstick adhesion rates when each sample of Examples 1 to 5 and Reference Example 1 was used.

[0038] [Table 2]

[0039] In the case of the specimens of Examples 1 to 5 in which the agent of the present invention was used, the lipstick adhesion rate to the HA plate was significantly lower than in Reference Example 1 in which water was used. The reason why a large amount of lipstick adhered in Reference Example 1, which used water, is thought to be that when the HA plate was pressed against the area on the sponge where the lipstick was to be applied, the water droplets adhering to the HA plate were repelled by the oil-soluble lipstick, resulting in direct contact between the HA plate and the lipstick. On the other hand, the reason why the lipstick adhesion rate was low when treated with the samples of Examples 1 to 5 using the agent of the present invention is thought to be that the sample adhered and remained on the HA plate, and when the HA plate was pressed against the area on the sponge where the lipstick had been applied, a layer of the sample was formed between the HA plate and the lipstick, thereby suppressing direct contact between the HA plate and the lipstick. The above results indicate that quaternary ammonium salts and glycyrrhizinic acid or its salts inhibit the adhesion of lipstick to tooth surfaces.

[0040] (Test Example 2) In order to confirm the effect of the agent of the present invention in inhibiting adhesion of lipstick to resin, the following test was carried out using a bottle cap made of polypropylene resin. The same specimen as in Test Example 1 was used.

[0041] (Test Example 2-1) [Test method] 1. Lipstick (product name: Reddit Creamy Balm Rouge 01 Terracotta Red, manufactured by StylingLife Holdings, Inc.) was applied to the surface of the sponge. 2. The outside bottom of the polypropylene resin bottle cap was immersed in each sample for 30 seconds. 3. The bottom of the outside of the bottle cap, which had been immersed in each sample, was pressed against the lipstick-applied area on the sponge with a pressure of about 1N. 4. The rate of lipstick adhesion to the bottom of the outside of the bottle cap was calculated using the following formula. Lipstick adhesion rate (%) = (lipstick adhesion area value / contact area value) x 100 The lipstick adhesion area value and contact area value were determined as follows. First, the main surface of the outer bottom of the bottle cap pressed against the lipstick application area on the sponge was photographed. Next, the number of pixels (px) in the image of the main surface of the outer bottom of the bottle cap was measured using the image processing software "ImageJ." Furthermore, the area (px) of the lipstick attached to the main surface of the outer bottom of the bottle cap was calculated using the same image processing software "ImageJ." The obtained area (px) of the main surface of the HA was designated the "contact area value" (a), and the lipstick-adhered area (px) was designated the "lipstick-adhered area value" (b).

[0042] Table 3 and FIG. 2 show the lipstick adhesion rates when each sample of Examples 1 to 5 and Reference Example 1 was used.

[0043] [Table 3]

[0044] In the cases of the specimens of Examples 1 to 5, which used the agent of the present invention, the rate of lipstick adhesion to the resin bottle cap was significantly lower than in Reference Example 1, which used water. This is thought to be because, as in Test Example 1, the specimen adhered and remained on the bottom of the resin bottle cap, and when the bottle cap was pressed against the lipstick application part on the sponge, a layer of the specimen was formed between the bottle cap and the lipstick, thereby suppressing direct contact between the bottle cap and the lipstick. The above results indicate that quaternary ammonium salts and glycyrrhizinic acid or its salts inhibit adhesion of lipstick to resin.

[0045] (Test Example 2-2) [Test method] 1. Each sample was poured into the polypropylene resin bottle cap used in Test Example 2-1. 2. With lipstick (product name: Reddit Creamy Balm Rouge 01 Terracotta Red, manufactured by StylingLife Holdings, Inc.) applied in excess to the lips, each sample was placed in the mouth using the bottle cap. 3. Observe the lipstick on the bottle cap.

[0046] FIG. 3 shows photographs of the outside of the bottle cap when the samples of Example 1 and Reference Example 1 were applied. 3, when the sample of Example 1 was used, adhesion of lipstick to the bottle cap was inhibited in the areas indicated by the arrows, and it was confirmed that lipstick adhered to the bottle cap tended to be easily removed. On the other hand, when the water of Reference Example 1 was used, lipstick adhered to the circled areas, etc., and the effect of inhibiting lipstick adhesion was not sufficient. These results demonstrate that quaternary ammonium salts and glycyrrhizinic acid or its salts inhibit lipstick adhesion to polypropylene resin bottle caps. This effect may contribute to maintaining the hygiene of products used by multiple people by reducing the risk of lip product components being mixed into the product via the bottle cap and of lip product components being attached to or ingested by others.

Claims

1. A lip preparation adhesion inhibitor containing at least one of the following components (A) and (B), which is to be applied to at least one target selected from oral tissue and skin to inhibit adhesion of a lip preparation to the target: (A) at least one quaternary ammonium salt selected from cetylpyridinium chloride, benzethonium chloride, benzalkonium chloride, and hexadecyltrimethylammonium bromide (B) Glycyrrhizic acid or its salt

2. A method for inhibiting adhesion of a lip preparation to at least one target selected from oral tissue and skin, comprising applying at least one of the following components (A) and (B) to the target: (A) at least one quaternary ammonium salt selected from cetylpyridinium chloride, benzethonium chloride, benzalkonium chloride, and hexadecyltrimethylammonium bromide (B) Glycyrrhizic acid or its salt

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