Skin disinfectant cleanser composition

Abstract

To provide a skin sterilizing and washing composition that has reduced stimulation to skin, shows good foaming and foam quality (resilience) and does not make the washed skin squeaky, with a moist feel.SOLUTION: A skin sterilizing and washing composition contains (A) fatty acid salt excluding laurate, (B) N-acylaspartic acid salt and (C) N-acyl methyl taurine salt .SELECTED DRAWING: None

Description

[Technical Field]

[0001] The present invention relates to a cleanser composition, and more particularly to a mild skin disinfectant cleanser composition. [Background technology]

[0002] In recent years, the practice of washing hands and the body has been encouraged to prevent the transmission of pathogenic bacteria, and the frequency of using cleansers containing disinfectants has increased. There is a demand for cleansers that have a disinfecting effect and do not cause skin irritation even when washed frequently.

[0003] Patent Document 1 proposes a cleanser composition that combines isopropylmethylphenol or thymol with an amino acid-based surfactant or an amphoteric surfactant that is less irritating to the skin, while Patent Document 2 proposes a cleanser composition that combines glyceryl ether, an anionic surfactant with a sulfate group, and an alkyl glucoside. [Prior art documents] [Patent documents]

[0004] [Patent Document 1] Japanese Patent Application Laid-Open No. 2007-332355 [Patent Document 2] Japanese Patent Publication No. 2020-026407 Summary of the Invention [Problem to be solved by the invention]

[0005] However, these detergent compositions are detergents that combine a bactericide with a mild active agent, and although they are less irritating to the skin, they are not satisfactory in terms of preventing rough skin even after frequent cleansing actions.

[0006] The present invention has been made in view of the above-mentioned problems, and its object is to provide a skin germicidal cleanser composition that combines bactericidal and low-irritation functions. That is, the object is to provide a skin germicidal cleanser composition that contains a bactericidal component but is low-irritation, does not destroy the skin's barrier function, and does not cause irritation to the skin after cleansing. [Means for solving the problem]

[0007] As a result of intensive research to achieve the object of the present invention, the inventors discovered that a mild skin disinfectant cleanser composition can be obtained by combining isopropylmethylphenol, N-acylasparagine salt, and alkyl polyglucoside, and thus completed the present invention.

[0008] The present invention is a skin disinfectant cleanser composition characterized by containing the following components (A), (B), and (C): (A) Isopropylmethylphenol (B) N-acylaspartate (C) Alkyl polyglucoside

[0009] The second invention of the present application is a skin disinfectant cleanser composition characterized by containing the following components (A), (B), and (C): (A) Isopropylmethylphenol 0.05% by mass or more of the total mass (B) N-acylaspartate: 1.0% by mass or more of the total mass (C) Alkyl polyglucoside 2.0% by mass or more of the total mass [Effects of the Invention]

[0010] According to the present invention, it is possible to provide a skin germicidal cleanser composition that is mild while maintaining germicidal properties. DETAILED DESCRIPTION OF THE INVENTION

[0011] The skin disinfectant cleanser composition of the present invention will be described in detail below.

[0012] In the present invention, "low irritation" means that no irritation is felt in a sensory evaluation after a cleansing test, and that the transepidermal water loss (TEWL) value, which indicates the barrier function of the stratum corneum, after cleansing is significantly reduced compared to the control.

[0013] <Component (A)> The component (A) used in the skin germicidal cleanser composition of the present invention is isopropylmethylphenol. By incorporating component (A), a germicidal effect can be imparted.

[0014] In the skin germicidal cleanser composition of the present invention, the blending amount of component (A) is preferably 0.05 to 0.5% by mass. A blending amount of 0.05% by mass or more is preferable because a germicidal effect can be obtained. Furthermore, a blending amount of 0.5% by mass or less is preferable because the raw material odor of isopropyl methylphenol itself is suppressed, increasing palatability during use.

[0015] <(B) component> The component (B) used in the skin germicidal cleanser composition of the present invention is an N-acylaspartate. By incorporating the component (B), a skin germicidal cleanser composition that foams abundantly yet is less irritating can be obtained.

[0016] Such acyl groups are preferably fatty acid residues having 8 to 22 carbon atoms, and examples thereof include single acyl groups such as lauric acid, myristic acid, palmitic acid, stearic acid, isostearic acid, and oleic acid, acyl groups derived from coconut oil fatty acids, beef tallow fatty acids, castor oil fatty acids, olive oil fatty acids, and palm oil fatty acids, and mixtures thereof. Examples of salts of amino acid surfactants include alkali metal salts such as sodium salts and potassium salts, and lower alkanolamine salts, with sodium salts and potassium salts being preferred.

[0017] Specific examples of component (B) used in the skin germicidal cleanser composition of the present invention include sodium lauroyl aspartate, sodium myristoyl aspartate, sodium oleyl aspartate, etc. In the skin germicidal cleanser composition of the present invention, these sodium N-acylaspartates may be used alone or in combination of two or more.

[0018] In the skin disinfectant cleanser composition of the present invention, the blending amount of component (B) is preferably 1.0% by mass or more. 1.0% by mass or more is preferable because it provides good foaming and enhances the palatability during use. When two or more types are used in combination, the blending amount is the sum of the two.

[0019] <(C) component> The component (C) used in the skin germicidal cleanser composition of the present invention is an alkyl polyglucoside. By combining component (C) with component (B), a skin germicidal cleanser composition with low irritation is obtained. Although the mechanism behind this is unclear, it is presumed that the combination with component (B) inhibits the penetration of the active agent into the skin's lamellar layer.

[0020] Specific examples of component (C) include decyl glucoside, lauryl glucoside, myristyl glucoside, cocoyl glucoside, etc. These alkyl polyglucosides are commercially available. Specific examples include Mydol 10 and Mydol 12 (both manufactured by Kao Corporation), and the Plantacare series such as Plantacare 2000UP, Plantacare 1200UP, Plantacare 818UP, and Plantacare 800UP (all manufactured by BASF).These alkyl polyglucosides can be used alone or in combination of two or more types in the skin germicidal cleanser composition of the present invention.

[0021] In the skin germicidal cleanser composition of the present invention, the blending amount of component (C) is preferably 2.0% by mass or more, and more preferably 15% by mass or less. If it is 2.0% by mass or more, irritation can be suppressed. On the other hand, if it is 15% by mass or less, stickiness after cleansing does not occur, and the palatability during use is improved, which is preferable.

[0022] <Other ingredients> In addition to the above-mentioned components, the skin disinfectant cleanser composition of the present invention can contain a cationic derivative as appropriate, provided that the object of the present invention is not impaired. The cationic derivative and component (A) form a coacervation reaction, which reduces the penetration of the surfactant monomer into the skin and makes it possible to further reduce irritation.

[0023] As the cationic cellulose derivative, any cellulose-based compound having a cationic functional group such as quaternary ammonium introduced therein and having cationic properties as a whole can be used, and examples thereof include O-[2-hydroxy-3-(trimethylammonio)propyl]hydroxyethyl cellulose chloride, O-[2-hydroxy-3-(lauryldimethylammonio)propyl]hydroxyethyl cellulose chloride, etc. Specific examples of the cationic cellulose derivative used in the present invention include Polyquaternium-10 (manufactured by Toho Chemical Co., Ltd.), Polymer JR-400 (manufactured by UCC), Leoguard GP (manufactured by Lion Corporation), and Catinal LC-20 (manufactured by Toho Chemical Co., Ltd.).

[0024] In addition to the above-mentioned components, the skin disinfectant cleanser composition of the present invention may contain other components, such as anionic surfactants, amphoteric surfactants, nonionic surfactants, powders (pigments, colorants, resins, etc.), physiologically active ingredients, antioxidants, sequestering agents, preservatives, ultraviolet absorbers, fragrances, moisturizers, salts, solvents, pearlizing agents, neutralizing agents, insect repellents, enzymes, etc., as appropriate, provided that the purpose of the present invention is not impaired.

[0025] The anionic surfactant is not particularly limited, and examples thereof include triethanolamine lauryl sulfate, ammonium lauryl sulfate, sodium lauryl ether sulfate, polyoxyethylene lauryl ether sodium sulfate, polyoxyethylene coconut oil fatty acid amide ether potassium sulfate, sodium lauryl phosphate, polyoxyethylene lauryl ether sodium acetate, and the like, and one or more of these may be selected and used as appropriate.

[0026] The amphoteric surfactant is not particularly limited, but examples thereof include lauric acid amidopropyl betaine, coconut oil fatty acid amidopropyl betaine, lauryl dimethyl amino acetic acid betaine, 2-alkyl-N-carboxymethyl-N-hydroxyethyl imidazolinium betaine, sodium lauryl amino diacetate, sodium β-aminopropionate, and N-lauroyl-N'-carboxymethyl-N'-hydroxyethyl ethylenediamine sodium, and one or more of these may be selected and used as appropriate.

[0027] The nonionic surfactant is not particularly limited, but examples thereof include polyoxyethylene cetyl ether, sorbitan monostearate, polyoxyethylene sorbitan triisostearate, polyoxyethylene hydrogenated castor oil, polyoxyethylene monoisostearate, polyoxyethylene glyceryl dioleate, coconut oil fatty acid diethanolamide, coconut oil fatty acid monoethanolamide, and coconut oil fatty acid N-methylethanolamide. , polyoxyethylene polyoxypropylene glycol, polyethylene glycol monolaurate, etc., and one or more of them may be selected and used as appropriate.

[0028] Examples of the powder include pigments such as Red No. 201, Yellow No. 4, Blue No. 1, and Black No. 401, lake pigments such as Yellow No. 4 Al Lake and Yellow No. 203 Ba Lake, nylon powder, silk powder, silicone powder, cellulose powder, spherical silicone elastomer powder, polymers such as polyethylene powder, colored pigments such as yellow iron oxide, red iron oxide, chromium oxide, carbon black, ultramarine, and Prussian blue, white pigments such as zinc oxide and titanium oxide, extender pigments such as talc, mica, sericite, and kaolin, pearl pigments such as titanium mica, metal salts such as barium sulfate, calcium carbonate, magnesium carbonate, and magnesium silicate, inorganic powders such as silica and alumina, bentonite, smectite, and boron nitride. There are no particular limitations on the shape of these powders (spherical, rod-like, needle-like, plate-like, irregular, flaky, spindle-like, etc.).

[0029] Examples of the physiologically active ingredient include substances that impart some kind of physiological activity to the skin when applied to the skin. Examples include anti-inflammatory agents, anti-aging agents, UV protection agents, tightening agents, antioxidants, moisturizing agents, blood circulation promoters, antibacterial agents, disinfectants, drying agents, cooling agents, warming agents, vitamins, amino acids, wound healing promoters, irritation alleviators, analgesics, cell activators, enzyme components, etc. Examples of the physiologically active ingredient include natural plant extracts, seaweed extracts, herbal ingredients, and compounds, and among these, natural plant extracts, seaweed extracts, and herbal ingredients are particularly preferred in terms of safety.

[0030] Examples of the natural plant extracts, seaweed extracts, and herbal ingredients include angelica tree extract, hydrangea extract, althaea extract, aloe extract, apricot extract, ginkgo extract, fennel extract, oolong tea extract, angelica tree extract, scutellaria root extract, Phellodendron bark extract, St. John's wort extract, watercress extract, orange extract, dried seawater, seaweed extract, hydrolyzed wheat powder, hydrolyzed silk, chamomile extract, carrot extract, artemisia capillaris extract, licorice extract, kakyō extract, kiwi extract, cucumber extract, gardenia extract, kumazasa extract, sophora flavescens extract, walnut extract, grapefruit extract, chlorella extract, mulberry extract, black tea extract, yeast extract, collagen, salvia extract, soapwort extract, hawthorn extract, rehmannia root extract, lithospermum root extract, perilla extract, linden extract, peony extract, white birch extract, and horsetail extract. ivy extract, hawthorn extract, elderberry extract, yarrow extract, peppermint extract, sage extract, cnidium extract, Swertia japonica extract, soybean extract, Chinese laurel extract, thyme extract, tea extract, clove extract, tangerine peel extract, Angelica acutiloba extract, Peach kernel extract, Houttuynia cordata extract, tomato extract, natto extract, carrot extract, garlic extract, wild rose extract, honey, witch hazel extract, Japanese knotweed extract, bisabolol, loquat extract, Poria cocos extract, propolis, loofah extract, peppermint extract, linden extract, hop extract, Madonna lily flower extract, horse chestnut extract, soapberry extract, melissa extract, peach extract, saxifrage extract, yuzu extract, mugwort extract, lavender extract, lemon extract, astragalus extract, rosemary extract, and royal jelly extract.

[0031] In addition to the above-mentioned natural plant extracts, seaweed extracts, and herbal ingredients, other ingredients include, for example, biopolymers such as deoxyribonucleic acid, collagen, elastin, chitin, chitosan, and hydrolyzed eggshell membrane; moisturizing ingredients such as amino acids, sodium lactate, urea, sodium pyrrolidone carboxylate, betaine, and whey; oily ingredients such as sphingolipids, ceramides, cholesterol, cholesterol derivatives, and phospholipids; anti-inflammatory agents such as ε-aminocaproic acid, glycyrrhizic acid, β-glycyrrhetinic acid, lysozyme chloride, guaiazulene, and hydrocortisone; vitamins (A, B2, B6, C, D, and E), calcium pantothenate, biotin, nicotinamide, and vitamin C ester; allantoin; diisopropyl alcohol; Examples of effective active ingredients include mindichloroacetate, 4-aminomethylcyclohexanecarboxylic acid, etc.; antioxidants such as tocopherol, carotenoids, flavonoids, tannins, lignans, saponins, etc.; cell activators such as α-hydroxy acids, β-hydroxy acids, etc.; blood circulation promoters such as γ-oryzanol, vitamin E derivatives, etc.; disinfectants such as hinokitiol, benzalkonium chloride, etc.; cooling agents such as l-menthol, peppermint oil, etc.; and wound healing agents such as retinol, retinol derivatives, etc.

[0032] The skin germicidal cleanser composition of the present invention can be suitably used as a skin cleanser for face washing, cleansing, body shampoo, hand soap, shaving agent, massage agent, etc. Each of these can be used in the form of a viscous liquid, cream, etc., and is particularly suitable for use as a hand soap or liquid body shampoo.

[0033] The present invention will now be described in detail with reference to examples, but the present invention is not limited thereto. Prior to the examples, the test methods and evaluation methods employed in each example will be explained.

[0034] (a-1) Test method for irritation (TEWL) Human cleansing test: A glass cup was attached to the inner part of a human forearm, and the skin disinfectant cleanser composition solutions of each of the Examples and Comparative Examples were applied to recreate the cleansing solution condition. Evaluation was performed based on transepidermal water loss (TEWL), which indicates the barrier function of the stratum corneum. The measurement conditions and evaluation criteria are shown below. TEWL measurement: After collecting the cleansing solution, the sample was thoroughly rinsed, and any remaining water was wiped off. Then, measurements were performed using a Tewameter™ 300 (manufactured by CK Co., Ltd.) according to the prescribed method. The measurements were performed after acclimatizing for 20 minutes in an environment of 22°C and 50% RH. <Evaluation criteria> The TEWL value for each formulation of the Examples and Comparative Examples was based on the value (Comparative Example 1) when components (B) and (C) were not blended, and the amount of change in each formulation of the Examples and Comparative Examples was used as an evaluation index based on the following criteria. Therefore, the evaluation index for the formulation of Comparative Example 1, which does not blend components (B) and (C), was set to "standard." ◎: Great effect in reducing irritation...significantly reduced (P>0.05) 〇: Small irritation alleviation effect... No significant difference, but there is a tendency for it to decrease ×: Irritating...No change or increase

[0035] (a-2) Test method for irritation (sensory test) Irritation Evaluation: A panel of 10 experts with sensitive skin used the antiseptic cleanser compositions of Examples and Comparative Examples five times a day and evaluated the irritation by sensory evaluation. The evaluation criteria were as follows: <Evaluation criteria> ◎: No irritation. Fewer than two subjects answered that there was irritation. ○: Slightly no irritation. The number of subjects who answered that there was irritation was 2 or more but less than 5. △: Slightly irritating. The number of subjects who answered that there was irritation was 5 or more but less than 8. ×: Stimulating. Eight or more subjects answered that there was stimulation.

[0036] (b) Test method for bactericidal activity The antiseptic skin cleanser compositions shown in Tables 1 and 2 were prepared at a concentration of 10% (changed from 1%). A paper disk (ADVANTEC THICK 8 mm) was placed on MSA agar medium smeared with 100 μL of Staphylococcus aureus bacteria solution, and 50 μL of the test substance was soaked in the disk and cultured at 37°C for 48 hours. After culture, the size of the inhibition zone of the test substance was measured using a vernier caliper. <Evaluation criteria> ◎: High bactericidal effect Inhibition zone size: 5mm~15mm 〇: Small bactericidal effect Inhibition zone size: 3mm~5mm ×: No bactericidal effect Inhibition zone size: 0mm-3mm

[0037] (c) Test method for stickiness after washing A panel of 10 experts used the skin disinfectant cleanser compositions of the Examples and Comparative Examples and evaluated stickiness after cleansing by sensory evaluation. The evaluation criteria were as follows: ◎: Not sticky. Fewer than two subjects answered that they felt sticky. ○: Slightly not sticky. The number of subjects who answered that they felt sticky was 2 or more but less than 5. △: Slightly sticky. The number of subjects who answered that it was sticky was 5 or more but less than 8. ×: Sticky and irritating. Eight or more subjects answered that it was irritating.

[0038] The results are shown in Tables 1 and 2. As is clear from Tables 1 and 2, the germicidal skin cleanser compositions of Examples 1 to 8, which used the components of the present invention, all exhibited superior performance compared to the compositions of Comparative Examples 1 to 10.

[0039] [Table 1]

[0040] [Table 2]

[0041] Other formulation examples of the body wash of the present invention are given below as Examples 12 to 14. The antiseptic skin cleanser compositions of these Examples were also examined for irritation and bactericidal activity.

[0042] Example 12 Hand Wash (mass%) (1) Sodium lauroyl aspartate 6.0 (2) Sodium Cocoyl Methyl Taurate 1.0 (3) Lauryl glucoside 3.0 (4) Lauryl hydroxysultaine 3.0 (5) Lauramidopropyl betaine 1.5 (6) Glycosyltrehalose 1.5 (7) Disodium edetate 0.1 (8) Phenoxyethanol 0.5 (9) DPG 2.0 (10) Glycerin 5.0 (11)Fragrance 0.3 (12) Sodium benzoate 0.4 (13) Peach Leaf Extract 0.001 (14) Aloe vera extract 0.001 (15) Sodium carbonate 0.05 (16) Isopropylmethylphenol 0.15 (17) Purified water remainder

[0043] Example 13 Body Wash (mass%) (1) Sodium lauroyl aspartate 5.0 (2) Sodium Cocoyl Methyl Taurate 2.0 (3) Decyl glucoside 7.0 (4) Lauryl hydroxysultaine 3.0 (5) Cocoyl methyl taurine magnesium 2.0 (6) Polyquaternium-10 0.4 (7) Cocamidopropyl betaine 1.5 (8) Sodium cocoamphoacetate 2.5 (9) Dimethyldiallylammonium chloride-acrylamide copolymer 0.5 (10) Hydroxypropyl methylcellulose 0.2 (11) Cocamide MEA 0.5 (12) Glycosyltrehalose 1.5 (13) Disodium edetate 0.2 (14)DPG 2.0 (15) Glycerin 3.0 (16) Lavender oil 0.2 (17) Orange oil 0.05 (18) Bergamot oil 0.01 (19) Myristic acid 1.0 (20) Citric acid 0.5 (21) Sodium benzoate 0.4 (22) Sodium carbonate 0.05 (23) Polysorbate 20 0.5 (24) Glycol distearate 1.0 (25) Isopropylmethylphenol 0.1 (26) Glycyrrhizic acid 2K 0.05 (27) Purified water remainder

[0044] Example 14 Face Wash (mass%) (1) Sodium lauroyl aspartate 8.0 (2) Sodium Cocoyl Methyl Taurate 2.0 (3) Decyl glucoside 5.0 (4) Lauryl hydroxysultaine 3.0 (5) Cocoyl methyl taurine magnesium 3.0 (6) Polyquaternium-10 0.4 (7) Cocamidopropyl Betaine 2.0 (9) Dimethyldiallylammonium chloride-acrylamide copolymer 0.5 (10) Hydroxypropylmethylcellulose 0.9 (12) Glycosyltrehalose 1.0 (13) Disodium edetate 0.2 (14) Phenoxyethanol 0.5 (15)DPG 9.0 (16) Glycerin 7.0 (17) Diglycerin 1.0 (18) Olive Leaf Extract 0.001 (19)Fragrance 0.2 (20) Citric acid 0.5 (21) Polysorbate 20 0.5 (22) Isopropylmethylphenol 0.05 (23) Glycyrrhizic acid 2K 0.05 (24) Purified water remainder

[0045] A skin germicidal cleanser composition having the above composition was prepared by a conventional method, and when its irritation and bactericidal properties were evaluated, both properties were excellent and good results were obtained.

Claims

1. A skin disinfectant cleanser composition comprising the following components (A), (B), and (C), and further comprising a cationic cellulose derivative: (A) Isopropylmethylphenol (B) N-acylaspartate (C) Alkyl polyglucoside 2.0 to 5.0% by mass of the total mass

2. A skin disinfectant cleanser composition comprising the following components (A), (B), and (C), and further comprising a cationic cellulose derivative: (A) Isopropylmethylphenol 0.05% by mass or more of the total mass (B) N-acylaspartate: 1.0% by mass or more of the total mass (C) Alkyl polyglucoside: 2.0 to 5.0% by mass of the total mass

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