Composition

Abstract

To provide an oral liquid composition which contains collagen abundantly and in which the distinct odor of collagen is decreased.SOLUTION: One aspect of the present invention is an oral liquid composition, comprising: 6 g / 100 ml or more and less than 20 g / 100 ml of collagen; and more than 0.25 g / 100 ml and less than 2.0 g / 100 ml of one or more imidazole dipeptides selected from the group consisting of anserine, carnosine, balenine, homoanserine, and homocarnosine.SELECTED DRAWING: None

Description

Technical Field

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[0001] The present invention relates to an oral liquid composition containing collagen and imidazole dipeptide, a method for producing the same, and a method for improving the taste quality of a collagen-containing oral liquid composition.

Background Art

[0002] Collagen has originally been a raw material widely used in the food field, but has recently attracted attention due to the increasing health consciousness. Collagen is an animal protein and is the main component of the dermis and connective tissues. Therefore, products utilizing collagen have been developed in the medical field, the cosmetic field, and the health food field.

[0003] For example, Japanese Patent No. 6956846 (Patent Document 1) describes a lumbago-improving agent and a trunk muscle strength-improving agent containing type II collagen, proteoglycan, hyaluronic acid, and imidazole dipeptide.

[0004] Moreover, the popularity of chicken extract beverages rich in collagen is increasing, mainly in Asia.

Prior Art Documents

Patent Documents

[0005]

Patent Document 1

Summary of the Invention

Problems to be Solved by the Invention

[0008] The present invention provides the following oral liquid compositions and a method for producing said oral liquid compositions. [1] An oral liquid composition, Collagen that is 6g / 100ml or more and less than 20g / 100ml One or more imidazole dipeptides selected from the group consisting of anserine, carnosine, balenine, homoanserine, and homocarnosine, in amounts exceeding 0.25 g / 100 ml and less than 2.0 g / 100 ml. A composition containing the following: [2] The composition according to [1], wherein the content of one or more imidazole dipeptides is 0.3 to 1.6 g / 100 ml. [3] The composition according to [1], wherein the content of one or more imidazole dipeptides is 0.35 to 1.4 g / 100 ml. [4] The collagen content is 6-11g / 100ml, The composition according to [1], wherein the content of one or more imidazole dipeptides is 0.5 to 1.3 g / 100 ml. [5] The collagen content is 6-10g / 100ml, The composition according to [1], wherein the content of one or more imidazole dipeptides is 0.6 to 1.25 g / 100 ml. [6] Let Y (g / 100ml) be the collagen content, and X (g / 100ml) be the total content of carnosine and anserine. Then, equation (1): Y≧-17.705X+16.705 (1) A composition according to any one of [3] to [5] that satisfies the following conditions. [7] A composition according to any one of [1] to [6], comprising anserine and carnosine. [8] A composition according to any one of [1] to [7], comprising 50 to 200 mg / 100 mL of sodium. [9] A composition according to any one of [1] to [8], containing 300 to 900 mg / 100 mL of BCAAs.

[10] A soup in a pouch, as described in any of [1] to [9].

[11] A method for improving the taste quality of a collagen-containing oral liquid composition, wherein the collagen-containing oral liquid composition contains 6 g / 100 ml or more of collagen, and is adjusted to contain 0.04 to 0.5 g of one or more imidazole dipeptides selected from the group consisting of anserine, carnosine, balenine, homoanserine, and homocarnosine per 1 g of collagen in the collagen-containing oral liquid composition.

[12] The method according to

[11] , wherein the amount of collagen contained in the collagen-containing oral liquid composition is less than 20 g / 100 ml. [Effects of the Invention]

[0009] According to one aspect of the present invention, an oral liquid composition rich in collagen and having a reduced characteristic collagen odor can be provided. According to a preferred aspect of the present invention, an oral liquid composition rich in collagen is provided, having a reduced characteristic collagen odor (fishy smell) and reduced bitterness. [Modes for carrying out the invention]

[0010] Hereinafter, the present invention will be described in detail. The following embodiments are examples for explaining the present invention, and the present invention is not intended to be limited only to these embodiments. The present invention can be implemented in various forms without departing from its gist. All documents, published gazettes, patent gazettes, and other patent documents cited in this specification shall be incorporated herein by reference.

[0011] 1. Oral liquid composition In one aspect, the present invention provides an oral liquid composition containing collagen and imidazole dipeptide (hereinafter also referred to as "the oral liquid composition of the present invention").

[0012] As used herein, the "oral liquid composition" means a liquid composition that can be orally ingested, and includes highly fluid beverages such as soft drinks or ready-to-drink (RTD) beverages, and beverages with relatively low fluidity such as jelly-like beverages. Furthermore, the oral liquid composition also includes compositions that are heated and drunk in a soup-like state, such as soup in a pouch (such as Chicken Essence or Drip Essence of Chicken). The liquid composition in a preferred embodiment of the present invention is soup in a pouch.

[0013] The oral liquid composition according to an embodiment of the present invention contains collagen at 6 g / 100 ml or more and less than 20 g / 100 ml, and one or more imidazole dipeptides selected from the group consisting of anserine, carnosine, balenine, homanserine, and homocarnosine, each of which exceeds 0.25 g / 100 ml and is 2.0 g / 100 ml or less. Hereinafter, the oral liquid composition of the present invention will be described.

[0014] <Collagen> Collagen is a protein that makes up the dermis, ligaments, tendons, bones, and cartilage, and is the main component of the extracellular matrix in multicellular animals. Collagen can be classified into several types depending on the site from which it is obtained, but the collagen used in this invention is not particularly limited.

[0015] In some embodiments of the present invention, collagen may include collagen peptides. Collagen peptides are obtained by breaking down collagen into relatively low molecular weight molecules. Collagen peptides are preferred over ordinary collagen in that they are more readily absorbed into the body when ingested orally. The average molecular weight (Mw) of the collagen peptide is not particularly limited, but for example, one with a molecular weight of 8,000 or less can be used. In the case of commercially available collagen products, the molecular weight can be determined according to the product information provided by the supplier, but if such information is not available, it can be measured by a conventional method using gel permeation chromatography (GPC: polyethylene glycol (PEG) standard). Examples of commercially available collagen peptides include "Peptan F 2000 HD" (average molecular weight (Mw): 2000) manufactured by Rousselot.

[0016] The origin of the collagen is not particularly limited, and any collagen that can be used in food and beverages can be used. In some embodiments, the collagen used is chicken-derived or fish-derived collagen. Purified collagen may be added separately, or it may be included by adjusting the amount of collagen-containing raw materials such as chicken extract. The collagen source may be one type or two or more types.

[0017] In some embodiments of the present invention, the amount of collagen contained in the oral liquid composition is 6 g / 100 ml or more and less than 20 g / 100 ml. By keeping the amount of collagen within this range and combining it with the imidazole dipeptide described later, it is possible to reduce the characteristic fishy odor of collagen while maintaining a high level of collagen content in the oral liquid composition. A higher collagen content is expected to enhance health benefits and is likely to have a strong appeal to consumers. In preferred embodiments of the present invention, the collagen content is 6-19g / 100ml, 6-18g / 100ml, 6-17g / 100ml, 6-16g / 100ml, 6-15g / 100ml, 6-14g / 100ml, 6-13g / 100ml, 6-12g / 100ml, 6-11g / 100ml, 6-10g / 100ml, 6g / 100ml or more and less than 10g / 100ml, 6-9g / 100ml, 6-8g / 10 0ml, 6g-7g / 100ml, over 6g / 100ml and less than 13g / 100ml, over 6g / 100ml and 12g / 100ml or less, over 6g / 100ml and 11g / 100ml or less, over 6g / 100ml and 10g / 100ml or less, over 6g / 100ml and less than 10g / 100ml, over 6g / 100ml and 9g / 100ml or less, over 6g / 100ml and 8g / 100ml or less, 6g Over 100ml and 7g / 100ml or less, 6.1~13g / 100ml, 6.1g / 100ml or more and less than 13g / 100ml, 6.1~12g / 100ml, 6.1~11g / 100ml, 6.1~10g / 100ml, 6.1g / 100ml or more and less than 10g / 100ml, 6.1~9g / 100ml, 6.1~8g / 100ml, 6.1~7g / 100ml, 6.2g / 100ml or more and 13 Less than g / 100ml, 6.2-12g / 100ml, 6.2-11g / 100ml, 6.2-10g / 100ml, 6.2g / 100ml or more and less than 10g / 100ml, 6.2-9g / 100ml, 6.2-8g / 100ml, 6.2-7g / 100ml, 6.5g / 100ml or more and less than 13g / 100ml, 6.5-12g / 100ml, 6.5-11g / 100ml, 6.5-10g / 100ml, 6.It may be 5g / 100ml or more and less than 10g / 100ml, 6.5-9g / 100ml, 6.5-8g / 100ml, 6.5-7g / 100ml, 7g / 100ml or more and less than 13g / 100ml, 7-12g / 100ml, 7-11g / 100ml, 7-10g / 100ml, 7g / 100ml or more and less than 10g / 100ml, 7-9g / 100ml, 7-8g / 100ml, 8g / 100ml or more and less than 13g / 100ml, 8-12g / 100ml, 8-11g / 100ml, 8-10g / 100ml, 8g / 100ml or more and less than 10g / 100ml, or 8-9g / 100ml. The collagen content is more preferably 6-11g / 100ml, 6-10g / 100ml, or 6.1g / 100ml or more, and less than 10g / 100ml.

[0018] The collagen content can be determined by quantifying the hydroxyproline contained in the oral liquid composition using an amino acid analyzer. However, if the content can be calculated from the amount used, it can be determined from that amount. When measuring with an amino acid analyzer, the measurement conditions can be the standard measurement method of the analyzer. As an amino acid analyzer, a fully automated amino acid analyzer (JLC-500 / V2) manufactured by JEOL Corporation can be used. The hydroxyproline coefficient necessary to calculate the collagen content from the hydroxyproline content can be calculated from the amino acid composition data of the collagen in the raw material (e.g., chicken, fish, pork, etc.). For example, if you want to determine the collagen content from the hydroxyproline content derived from chicken or pork, you can calculate it by multiplying the hydroxyproline content by a coefficient of 8.

[0019] <Imidazole dipeptide> The oral liquid compositions in some embodiments of the present invention contain imidazole dipeptides. Imidazole dipeptides are a general term for dipeptides having histidine with an imidazole ring as a component (Nobuya Yanai, Journal of the Japan Society for Food Chemistry and Technology, 2014, Vol. 61, No. 1, p. 45). Here, imidazole is a type of five-membered cyclic aromatic heterocyclic compound, and is a nitrogen-containing aromatic heterocyclic compound having nitrogen atoms at the 1st and 3rd positions.

[0020] The inventors have surprisingly discovered that by using one or more imidazole dipeptides selected from the group consisting of anserine, carnosine, balenine, homoanserine, and homocarnosine together with collagen in an oral liquid composition, the characteristic odor (fishy smell) of collagen can be effectively suppressed. This fishy smell can also be described as a trimethylamine-like odor. In a preferred embodiment, the unique bitterness of the imidazole dipeptide is also reduced when combined with a predetermined amount of collagen.

[0021] There are various types of imidazole dipeptides, and may include imidazole dipeptides other than anserine, carnosine, balenine, homoanserine, and homocarnosine. The oral liquid composition in some embodiments of the present invention contains one or more imidazole dipeptides selected from the group consisting of anserine and carnosine. The oral liquid composition in a preferred embodiment of the present invention contains anserine and carnosine.

[0022] The imidazole dipeptides used in the oral liquid compositions in some embodiments of the present invention may be obtained by extraction from a material containing imidazole dipeptides (e.g., fish meat) with an aqueous solvent, or by chemical synthesis, and their origin and raw materials are not particularly limited. Imidazole dipeptides can be obtained from fish meat such as tuna, bonito, and salmon, as well as beef, pork, and chicken. Mammals such as pigs and cattle contain a lot of carnosine, aquatic mammals have a carnosine to balenine ratio of about 1:2, birds have a carnosine to anserine ratio of 1:3, and large fish are said to contain almost only anserine (Nobuya Yanai, Journal of the Japan Society for Food Chemistry and Technology, 2014, Vol. 61, No. 1, p. 45). In the present invention, the raw materials for imidazole dipeptides can be selected according to the desired efficacy and application.

[0023] In some embodiments of the present invention, the amount of one or more imidazole dipeptides selected from the group consisting of anserine, carnosine, balenine, homoanserine, and homocarnosine contained in the oral liquid composition is greater than 0.25 g / 100 ml and less than 2.0 g / 100 ml. If the oral liquid composition contains two or more imidazole dipeptides selected from the group consisting of anserine, carnosine, balenine, homoanserine, and homocarnosine, the amount described herein refers to the total amount of those imidazole dipeptides. By setting the content of the predetermined imidazole dipeptides within this range, it is possible to reduce the characteristic odor (fishy smell) of collagen while also reducing the bitterness of the imidazole dipeptides, thereby providing a liquid composition with excellent taste quality. Preferably, the content of one or more imidazole dipeptides selected from the group consisting of anserine, carnosine, balenine, homoanserine, and homocarnosine is 0.26-1.9g / 100ml, 0.26-1.8g / 100ml, 0.26-1.7g / 100ml, 0.26-1.6g / 100ml, 0.26-1.5g / 100ml, and 0.26-1.4g. / 100ml, 0.26~1.3g / 100ml, 0.26~1.2g / 100ml, 0.26~1.1g / 100ml, 0.26~1.0g / 100ml, 0.26~0.9g / 100ml, 0.26~0.8g / 100ml, 0.26~0.7g / 100ml, 0.26~0.6g / 100ml, 0.3~1.9g / 100ml, 0.3~1.8g / 100ml , 0.3~1.7g / 100ml, 0.3~1.6g / 100ml, 0.3~1.5g / 100ml, 0.3~1.4g / 100ml, 0.3~1.3g / 100ml, 0.3~1 .2g / 100ml, 0.3~1.1g / 100ml, 0.3~1.0g / 100ml, 0.3~0.9g / 100ml, 0.3~0.8g / 100ml, 0.3~0.7g / 100 ml, 0.3~0.6g / 100ml, 0.35~1.9g / 100ml, 0.35~1.8g / 100ml, 0.35~1.7g / 100ml, 0.35~1.6g / 100ml, 0.35~1.5g / 100ml, 0.35~1.4g / 100ml, 0.35~1.3g / 100ml, 0.35~1.2g / 100ml, 0.35~1.1g / 100ml, 0.35~1.0g / 100ml, 0.35~0.9g / 100ml, 0.35~0.8g / 100ml, 0.35~0.7g / 100ml, 0.35~0.6g / 100ml, 0.45~1.9g / 100 ml, 0.45~1.8g / 100ml, 0.45~1.7g / 100ml, 0.45~1.6g / 100ml, 0.45~1.5g / 100ml, 0.45~1.4g / 100ml, 0.45~1.3g / 100ml, 0.45~1.2g / 100ml, 0.45~1.1g / 100ml, 0.45~1.0g / 100ml, 0.45~0.9g / 100ml, 0.45~0.8g / 100ml, 0.45~0.7g / 100ml, 0.45~0.6g / 100ml, 0.5~1.9g / 100ml, 0.5~1.8g / 100ml, 0.5~1.7g / 100ml, 0.5~1.6g / 100ml, 0.5~ 1.5g / 100ml, 0.5~1.4g / 100ml, 0.5~1.3g / 100ml, 0.5~1.2g / 100ml, 0.5~1.1g / 100ml, 0.5~1.0g / 100ml, 0.5~0 .9g / 100ml, 0.5~0.8g / 100ml, 0.5~0.7g / 100ml, 0.5~0.6g / 100ml, 0.6~1.9g / 100ml, 0.6~1.8g / 100ml, 0.6~1.7 The imidazole dipeptide content may be g / 100ml, 0.6-1.6g / 100ml, 0.6-1.5g / 100ml, 0.6-1.4g / 100ml, 0.6-1.25g / 100ml, 0.6-1.3g / 100ml, 0.6-1.2g / 100ml, 0.6-1.1g / 100ml, 0.6-1.0g / 100ml, 0.6-0.9g / 100ml, 0.6-0.8g / 100ml, or 0.6-0.7g / 100ml. More preferably, the imidazole dipeptide content may be 0.3-1.6g / 100ml or 0.35-1.4g / 100ml. Alternatively, in other embodiments, the imidazole dipeptide content may be 0.5 g / 100 ml or more and less than 1.0 g / 100 ml, 0.5 g / 100 ml or more and 1.0 g / 100 ml or less, 0.6 g / 100 ml or more and 1.3 g / 100 ml or less, or 0.6 g / 100 ml or more and 1.25 g / 100 ml or less.

[0024] In some embodiments of the present invention, the total amount of anserine and carnosine contained in the oral liquid composition is greater than 0.25 g / 100 ml and less than 2.0 g / 100 ml. By keeping the total content of anserine and carnosine within this range, it is possible to reduce the characteristic odor (fishy smell) of collagen while also reducing the bitterness of anserine and carnosine, thereby providing a liquid composition with excellent taste quality. Preferably, the total content of anserine and carnosine is 0.26-1.9g / 100ml, 0.26-1.8g / 100ml, 0.26-1.7g / 100ml, 0.26-1.6g / 100ml, 0.26-1.5g / 100ml, 0.26-1.4g / 100ml, 0.26-1.3g / 100ml, 0.26-1.2g / 100ml, 0.26-1.1g / 100ml, 0.26-1.0g / 100ml, 0.26-0.9g / 100ml, 0.2 6~0.8g / 100ml, 0.26~0.7g / 100ml, 0.26~0.6g / 100ml, 0.3~1.9g / 100ml, 0.3~1.8g / 100ml, 0.3~1.7g / 100ml, 0.3~1.6g / 100 ml, 0.3~1.5g / 100ml, 0.3~1.4g / 100ml, 0.3~1.3g / 100ml, 0.3~1.2g / 100ml, 0.3~1.1g / 100ml, 0.3~1.0g / 100ml, 0.3~0.9g / 1 00ml, 0.3~0.8g / 100ml, 0.3~0.7g / 100ml, 0.3~0.6g / 100ml, 0.35~1.9g / 100ml, 0.35~1.8g / 100ml, 0.35~1.7g / 100ml, 0.35 ~1.6g / 100ml, 0.35~1.5g / 100ml, 0.35~1.4g / 100ml, 0.35~1.3g / 100ml, 0.35~1.2g / 100ml, 0.35~1.1g / 100ml, 0.35~1.0g / 100ml, 0.35~0.9g / 100ml, 0.35~0.8g / 100ml, 0.35~0.7g / 100ml, 0.35~0.6g / 100ml, 0.45~1.9g / 100ml, 0.45~1.8g / 100ml, 0.45~1.7g / 100ml, 0.45~1.6g / 100ml, 0.45~1.5g / 100ml, 0.45~1.4g / 100ml, 0.45~1.3g / 100ml, 0.45~1.2g / 100ml, 0.45~1.1g / 100ml, 0.45~1.0g / 100ml, 0.45~0.9g / 100ml, 0.45~0.8g / 100ml, 0.45~0. 7g / 100ml, 0.45~0.6g / 100ml, 0.5~1.9g / 100ml, 0.5~1.8g / 100ml, 0.5~1.7g / 1 00ml, 0.5~1.6g / 100ml, 0.5~1.5g / 100ml, 0.5~1.4g / 100ml, 0.5~1.3g / 100ml, 0.5~1.2g / 100ml, 0.5~1.1g / 100ml, 0.5~1.0g / 100ml, 0.5~0.9g / 100ml, 0.5~0 It may also be 0.8g / 100ml, 0.5~0.7g / 100ml, 0.5~0.6g / 100ml, 0.6~1.9g / 100ml, 0.6~1.8g / 100ml, 0.6~1.7g / 100ml, 0.6~1.6g / 100ml, 0.6~1.5g / 100ml, 0.6~1.4g / 100ml, 0.6~1.25g / 100ml, 0.6~1.3g / 100ml, 0.6~1.2g / 100ml, 0.6~1.1g / 100ml, 0.6~1.0g / 100ml, 0.6~0.9g / 100ml, 0.6~0.8g / 100ml, or 0.6~0.7g / 100ml. More preferably, the total content of anserine and carnosine may be 0.3 to 1.6 g / 100 ml or 0.35 to 1.4 g / 100 ml. Alternatively, in other embodiments, the total content of anserine and carnosine may be 0.5 g / 100 ml or more and less than 1.0 g / 100 ml, 0.5 g / 100 ml or more and 1.0 g / 100 ml or less, 0.6 g / 100 ml or more and 1.3 g / 100 ml or less, or 0.6 g / 100 ml or more and 1.25 g / 100 ml or less.

[0025] The imidazole dipeptide content can be determined by measuring it using high-performance liquid chromatography (HPLC), but if the content can be calculated from the formulation amount, it can also be determined from that. When measuring by HPLC, the measurement conditions can be determined using the standard measurement method of the analyzer. When measuring by HPLC, an ion exchange column (for example, 300SCX (dimensions: 4.6 × 250 mm, particle size: 5 μm)) can be used.

[0026] In some embodiments of the present invention, the ratio of collagen content to the content of one or more imidazole dipeptides selected from the group consisting of anserine, carnosine, balenine, homoanserine, and homocarnosine (collagen / imidazole dipeptide) is not particularly limited, but may be, for example, 3-50, 3-40, 3-30, 3-25, 3-20, 3-15, 3-10, 4-50, 4-40, 4-30, 4-25, 4-20, 4-15, 4-10, 5-50, 5-40, 5-30, 5-25, 5-20, 5-15, or 5-10.

[0027] In some embodiments of the present invention, the ratio of collagen content to the total content of anserine and carnosine (collagen / [anserine + carnosine]) is not particularly limited, but may be, for example, 3-50, 3-40, 3-30, 3-25, 3-20, 3-15, 3-10, 4-50, 4-40, 4-30, 4-25, 4-20, 4-15, 4-10, 5-50, 5-40, 5-30, 5-25, 5-20, 5-15, or 5-10.

[0028] An oral liquid composition in a preferred embodiment of the present invention is an oral liquid composition having a collagen content of 6 to 11 g / 100 ml and a content of 0.5 to 1.3 g / 100 ml of one or more imidazole dipeptides selected from the group consisting of anserine, carnosine, balenine, homoanserine, and homocarnosine. An oral liquid composition in another preferred embodiment of the present invention is an oral liquid composition having a collagen content of 6 to 10 g / 100 ml and a content of 0.6 to 1.25 g / 100 ml of one or more imidazole dipeptides selected from the group consisting of anserine, carnosine, balenine, homoanserine, and homocarnosine.

[0029] An oral liquid composition in yet another preferred embodiment of the present invention is an oral liquid composition having a collagen content of 6 to 11 g / 100 ml and a total content of anserine and carnosine of 0.5 to 1.3 g / 100 ml. An oral liquid composition in yet another preferred embodiment of the present invention is an oral liquid composition having a collagen content of 6 to 10 g / 100 ml and a total content of anserine and carnosine of 0.6 to 1.25 g / 100 ml.

[0030] In some embodiments of the present invention, the oral liquid composition is given by formula (1) when the collagen content is Y (g / 100ml) and the total content of carnosine and anserine is X (g / 100ml): Y≧-17.705X+16.705 (1) The following conditions are met. Equation (1) is based on the equation of the linear approximation curve obtained from the data of Examples 1-14, 1-33, and 1-35 in Example 1 described later. It is preferable that the range on the graph is above this linear approximation curve because it reduces the collagen-specific odor (fishy smell) and bitterness of the oral liquid composition.

[0031] <Chicken extract> In some embodiments of the present invention, the oral liquid composition may contain chicken extract as a raw material containing collagen and one or more imidazole dipeptides selected from the group consisting of anserine, carnosine, balenine, homoanserine, and homocarnosine. Chicken extract is a component obtained by hot water extraction or the like from parts of chicken such as meat, bones, legs, and skin. Chicken extract generally contains one or more imidazole dipeptides selected from the group consisting of carnosine and anserine.

[0032] In some embodiments of the present invention, when the chicken extract used in the oral liquid composition contains a salt of one or more imidazole dipeptides selected from the group consisting of carnosine and anserine, the imidazole dipeptide content in the chicken extract refers to the total amount of imidazole dipeptides and their salts.

[0033] Examples of imidazole dipeptide salts include, but are not limited to, inorganic salts such as hydroxides, carbonates and bicarbonates of sodium, lithium, calcium, magnesium and aluminum and ammonia; as well as organic salts such as mono-, di- or tri-alkylamine salts, mono-, di- or tri-hydroxyalkylamine salts, guanidine salts and N-methylglucosamine salts, such as salts of methylamine, dimethylamine and trimethylamine.

[0034] In some embodiments of the present invention, when using chicken extract in an oral liquid composition, the extract may be obtained by heating chicken meat or other raw materials in a liquid, or a commercially available chicken extract may be used. The raw materials for the chicken extract may include chicken bones, cartilage, legs, etc.

[0035] Commercially available chicken extracts include "Brand's Essence of Chicken (BEC) (manufactured by Suntory Beverage & Food Asia)", "Scotch® Essence of Chicken (manufactured by Scotch Industrial, Thailand)", "Quaker Essence of Chicken (manufactured by Standard Foods Corporation, Taiwan)", "SWANSON® Chicken stock and broth (manufactured by Campbell Soup Company)", "Drip Chicken Essence (manufactured by Eu Yan Sang International, Singapore)", "Boned Chicken Tonic (manufactured by Eu Yan Sang International, Singapore)", and "Boiled Essence of Chicken (manufactured by Lao Xie Zhen, Taiwan)". Any of these commercially available products can be used, but Brand's Essence of Chicken (BEC) is preferred.

[0036] When producing the chicken extract used in the oral liquid compositions in some embodiments of the present invention by hot water extraction of chicken meat, chicken bones, cartilage, legs, etc. (hereinafter referred to as "chicken meat, etc."), it can be produced by commonly used methods. For example, chicken extract can be produced by treating chicken meat, etc. in a solvent at high temperature under atmospheric pressure or under pressure. When producing chicken extract, the concentration may be increased by removing fat and cholesterol after crude extraction in a solvent, and then removing excess solvent.

[0037] In this specification, chicken extract includes liquid extracts, diluted solutions, concentrates, or dried powders obtained by the above method, and their purified products. Purified products can be obtained, for example, by subjecting chicken extract to ultrafiltration, membrane treatment, liquid separation, or fractionation with resin to achieve high purity.

[0038] The amount of chicken extract (on a solid basis) in the oral liquid composition in some embodiments of the present invention is not particularly limited as long as the amounts of collagen and imidazole dipeptide are within a predetermined range, but it is preferably 5% to 25% by weight. In preferred embodiments of the present invention, the amount of chicken extract (on a solid basis) may be 8% to 16% by weight, 10% to 14% by weight, or 11% to 13% by weight.

[0039] <Other ingredients and properties> Oral liquid compositions according to some embodiments of the present invention contain water. The water is not particularly limited, and any water can be used as long as it does not adversely affect the flavor, but examples include tap water, deionized water, soft water, distilled water, carbonated water, reverse osmosis water (RO water), activated carbon treated water, purified water, and desalinated water.

[0040] Oral liquid compositions according to some embodiments of the present invention may contain branched-chain amino acids (BCAAs). The BCAAs may include one or more of valine, leucine, and isoleucine. The BCAA content is preferably 300-900 mg / 100 mL, more preferably 350-800 mg / 100 mL, even more preferably 400-700 mg / 100 mL, and even more preferably 500-600 mg / 100 mL. In this specification, the BCAA content refers to the total content of valine, leucine, and isoleucine, and the content of any one of these amino acids may be zero. The inclusion of BCAAs is preferable because it can be expected to have an effect on preventing fatigue. The amount of BCAA in the oral liquid composition can be determined by measuring with high-performance liquid chromatography (HPLC), but if the content can be calculated from the blending amount, it may be determined from the blending amount. When measuring with high-performance liquid chromatography (HPLC), the measurement conditions can be measured using the standard measurement method of the analyzer. When measuring using high-performance liquid chromatography (HPLC), a reversed-phase HPLC column (for example, RP-18 (dimensions: 25 × 0.46 cm, particle size: 5 μm)) can be used.

[0041] Oral liquid compositions according to some embodiments of the present invention may contain sodium. The sodium contained in the oral liquid composition may be derived from raw materials such as collagen, or it may be added separately in the form of sodium citrate or the like. The sodium content is preferably 50 to 200 mg / 100 mL, more preferably 70 to 180 mg / 100 mL, even more preferably 100 to 160 mg / 100 mL, and even more preferably 135 to 155 mg / 100 mL. The inclusion of sodium is preferable because it improves the body (mouthfeel). The amount of sodium in the oral liquid composition can be measured by atomic absorption spectrometry. If the amount of sodium-containing compound blended in the oral liquid composition is known, the value calculated from that amount may be used.

[0042] Sodium is not particularly limited in form as long as it is included in an oral liquid composition in an ingestible state, but may be, for example, at least one form selected from the group consisting of sodium chloride, sodium hydroxide, sodium malate, sodium sulfate, sodium citrate (monosodium citrate, disodium citrate, or trisodium citrate), sodium phosphate, sodium carbonate, sodium disulfide, sodium bicarbonate, sodium alginate, sodium arginate, sodium glucoheptanoate, sodium gluconate, sodium glutamate, sodium tartrate, sodium aspartate, sodium lactate, sodium caseinate, sodium ascorbate, and mixtures thereof, or in the form of an ionized product thereof.

[0043] The pH of the oral liquid composition according to some embodiments of the present invention may preferably be 4-7, 4.5-7, 5-7, 5.5-7, 6-7, 4-6.8, 4.5-6.8, 5-6.8, 5.5-6.8, 6-6.8, 4-6.6, 4.5-6.6, 5-6.6, 5.5-6.6, or 6-6.6. By adjusting the pH within this range, a desirable taste with less acidity can be achieved.

[0044] The Brix (soluble solids content) of the oral liquid composition according to some embodiments of the present invention is preferably 5 to 20, more preferably 8 to 16, and even more preferably 10 to 14. The Brix (soluble solids content) of the oral liquid composition can be measured with a sugar refractometer.

[0045] Oral liquid compositions according to some embodiments of the present invention may contain sweeteners. These sweeteners may include low-intensity sweeteners, high-intensity sweeteners, or combinations thereof. Examples of low-intensity sweeteners include glucose, sucrose (such as granulated sugar), fructose, maltose, oligosaccharides, fructose-glucose syrup, lactose, psicose, allose, tagatose, xylose, or ribose. Examples of high-intensity sweeteners include aspartame, neotame, advantame, sucralose, acesulfame potassium (acesulfame K), saccharin, sodium saccharin, sodium cyclamate, dulcin, disodium glycyrrhizinate, trisodium glycyrrhizinate, neohesperidin dihydrochalcone, thaumatin, monellin, curculin, mavinrin, blazein, pentadine, hernandulcin, 4β-hydroxyhernandulcin, miraculin, glycyrrhizin, rubusoside, phyllodulcin, mogroside IV, mogroside V, steviol glycosides (rebaudioside A, rebaudioside D, rebaudioside M), thaumatin, monellin, blazein, monatin, monatin, monk fruit extract, or stevia extract.

[0046] Oral liquid compositions according to some embodiments of the present invention may contain components other than those listed above that can be added to ordinary oral liquid compositions, as long as the effects of the present invention are not impaired. Examples of such components include acidulants, flavorings, vitamins, colorants, antioxidants, emulsifiers, preservatives, seasonings, extracts, pH adjusters, and quality stabilizers.

[0047] The form of the container for the oral liquid composition according to some embodiments of the present invention is not limited, and the oral liquid composition may be in the form of a container sealed in a container such as a can, bottle, PET bottle, pouch, paper carton, or plastic container. According to a preferred embodiment of the present invention, the container for the oral liquid composition is a small pouch from the viewpoint of easy and regular consumption. When heat sterilization is performed after packaging, the type is not particularly limited, and can be carried out using conventional methods such as inversion sterilization, UHT sterilization, and retort sterilization. The temperature of the heat sterilization process is not particularly limited, but for example, it is 65 to 130°C, preferably 80 to 120°C, for 1 to 40 minutes. However, if a sterilization value equivalent to the above conditions can be obtained, sterilization at an appropriate temperature for a few seconds, for example, 5 to 30 seconds, is also acceptable.

[0048] When taking an oral liquid composition according to some embodiments of the present invention, the recommended daily intake may be 100 ml / day, 80 ml / day, 68 ml / day, 50 ml / day, 42 ml / day, or 20 ml / day. Alternatively, if packaged in small bottles or pouches, one bottle or pouch may be taken per day.

[0049] [Embodimentary Embodiments of the Oral Liquid Composition of the Present Invention] The following are exemplary embodiments of the oral liquid composition of the present invention, but the present invention is not limited to the embodiments described below. According to one embodiment of the present invention, an oral liquid composition, Collagen that is 6g / 100ml or more and less than 20g / 100ml One or more imidazole dipeptides selected from the group consisting of anserine, carnosine, balenine, homoanserine, and homocarnosine, in amounts exceeding 0.25 g / 100 ml and less than 2.0 g / 100 ml. Includes, A composition is provided in which the total content of anserine and carnosine is 0.3 to 1.6 g / 100 ml, preferably 0.35 to 1.4 g / 100 ml, more preferably 0.5 to 1.3 g / 100 ml, even more preferably 0.6 to 1.0 g / 100 ml, and even more preferably 0.6 to 0.9 g / 100 ml.

[0050] According to one embodiment of the present invention, an oral liquid composition, 6-13g / 100ml or 6.1-13g / 100ml of collagen and One or more imidazole dipeptides selected from the group consisting of anserine, carnosine, balenine, homoanserine, and homocarnosine, in amounts exceeding 0.25 g / 100 ml and less than 2.0 g / 100 ml. Includes, A composition is provided in which the total content of anserine and carnosine is 0.3 to 1.6 g / 100 ml, preferably 0.35 to 1.4 g / 100 ml, more preferably 0.5 to 1.3 g / 100 ml, even more preferably 0.6 to 1.0 g / 100 ml, and even more preferably 0.6 to 0.9 g / 100 ml.

[0051] According to one embodiment of the present invention, an oral liquid composition, 6-11g / 100ml or 6.1-11g / 100ml of collagen and One or more imidazole dipeptides selected from the group consisting of anserine, carnosine, balenine, homoanserine, and homocarnosine, in amounts exceeding 0.25 g / 100 ml and less than 2.0 g / 100 ml. Includes, A composition is provided in which the total content of anserine and carnosine is 0.3 to 1.6 g / 100 ml, preferably 0.35 to 1.4 g / 100 ml, more preferably 0.5 to 1.3 g / 100 ml, even more preferably 0.6 to 1.0 g / 100 ml, and even more preferably 0.6 to 0.9 g / 100 ml.

[0052] According to one embodiment of the present invention, an oral liquid composition, 6-11g / 100ml or 6.1-11g / 100ml of collagen and 0.3-1.5 g / 100 ml of one or more imidazole dipeptides selected from the group consisting of anserine, carnosine, balenine, homoanserine, and homocarnosine Includes, A composition is provided in which the total content of anserine and carnosine is 0.35 to 1.4 g / 100 ml, preferably 0.5 to 1.3 g / 100 ml, more preferably 0.6 to 1.0 g / 100 ml, and even more preferably 0.6 to 0.9 g / 100 ml.

[0053] According to one embodiment of the present invention, an oral liquid composition, 6-11g / 100ml or 6.1-11g / 100ml of collagen and 0.3-1.5 g / 100 ml of one or more imidazole dipeptides selected from the group consisting of anserine, carnosine, balenine, homoanserine, and homocarnosine Includes, The total content of anserine and carnosine is 0.35 to 1.4 g / 100 ml, preferably 0.5 to 1.3 g / 100 ml, more preferably 0.6 to 1.0 g / 100 ml, and even more preferably 0.6 to 0.9 g / 100 ml. A composition containing 70-180 mg / 100 mL of sodium is provided.

[0054] 2. Method for producing oral liquid compositions In one embodiment, the present invention provides a method for producing the following oral liquid composition (hereinafter also referred to as "the production method of the present invention"). The production method of the present invention is not particularly limited as long as an oral liquid composition is obtained in which the content of collagen and one or more imidazole dipeptides selected from the group consisting of anserine, carnosine, balenine, homoanserine, and homocarnosine is within a predetermined range.

[0055] One embodiment of the present invention is a method of production, for example, as follows: First, chicken meat is finely chopped, and then the proteins contained in the chicken meat are broken down by processing in a solvent at high temperature and atmospheric or pressurized conditions, converting them into relatively low molecular weight peptides that are easily absorbed by humans. Fat and cholesterol are removed from the resulting crude extract, and then excess solvent is removed to increase the concentration of the chicken essence. This operation may be repeated multiple times. After confirming that the density, color, and nutritional value are within the desired range, the extract is filtered, then packaged in containers and vacuum-sealed. After that, it is heat-sterilized. Since the ratio of components contained differs depending on the part of the chicken meat used, an oral liquid composition with the desired amount of collagen and imidazole dipeptide can be obtained by adjusting the parts of the chicken meat used. For example, collagen tends to be found in large quantities in the legs of chickens, and imidazole dipeptide tends to be found in large quantities in the breast meat of chickens. Therefore, by analyzing the amount of components contained in each part and appropriately adjusting the ratio of the parts used, the oral liquid composition of the present invention can be produced without excessive burden.

[0056] Alternatively, the oral liquid composition of the present invention may be prepared by adding predetermined amounts of collagen and imidazole dipeptide to water, respectively. In this case, the amounts of collagen and imidazole dipeptide contained in the oral liquid composition may be adjusted by adding collagen and / or imidazole dipeptide to the chicken extract containing collagen and imidazole dipeptide as needed. The chicken extract may be prepared using chicken meat or the like by the method described above, but a commercially available product may also be used. The timing of adding each component may or may not be simultaneous.

[0057] In a manufacturing method according to one embodiment of the present invention, the definitions of "oral liquid composition," "collagen," "imidazole dipeptide," "chicken extract," and "other components and properties" are the same as those described in the section on oral liquid composition, and the numerical values ​​are the same as those described in the section on oral beverage composition.

[0058] 3. Method for improving the taste quality of collagen-containing oral liquid compositions In one aspect, the present invention provides a method for improving the taste quality of the following collagen-containing oral liquid composition (hereinafter also referred to as "the improvement method of the present invention"). According to the improvement method of the present invention, the characteristic odor (fishy smell) of collagen in the collagen-containing oral liquid composition can be reduced. Specifically, the characteristic odor (fishy smell) of collagen can be reduced by adjusting the oral liquid composition containing collagen to contain one or more imidazole dipeptides selected from the group consisting of anserine, carnosine, balenine, homoanserine, and homocarnosine at a predetermined concentration.

[0059] An improvement method according to one embodiment of the present invention is a method for improving the taste quality of a collagen-containing oral liquid composition, wherein the amount of collagen contained in the collagen-containing oral liquid composition is 6 g / 100 ml or more, and the composition is adjusted to contain 0.04 to 0.5 g of one or more imidazole dipeptides selected from the group consisting of anserine, carnosine, balenine, homoanserine, and homocarnosine per 1 g of collagen contained in the collagen-containing oral liquid composition.

[0060] In the improved method according to some embodiments of the present invention, the content of one or more imidazole dipeptides selected from the group consisting of anserine, carnosine, balenine, homoanserine, and homocarnosine per 1 g of collagen contained in the collagen-containing oral liquid composition is 0.04-0.4 g, 0.04-0.3 g, 0.04-0.25 g, 0.04-0.2 g, 0.04-0.15 g, 0.04-0.1 g, 0.05-0.4 g, 0.05-0.3 g, 0.05-0.25 g, 0.05- It may also be 0.2g, 0.05~0.15g, 0.05~0.1g, 0.06~0.4g, 0.06~0.3g, 0.06~0.25g, 0.06~0.2g, 0.06~0.15g, 0.06~0.1g, 0.07~0.4g, 0.07~0.3g, 0.07~0.25g, 0.07~0.2g, 0.07~0.15g, 0.07~0.1g, 0.08~0.4g, 0.08~0.3g, 0.08~0.25g, 0.08~0.2g, 0.08~0.15g, or 0.08~0.1g.

[0061] In improved methods according to several embodiments of the present invention, the total content of anserine and carnosine per 1g of collagen in the collagen-containing oral liquid composition is 0.04-0.4g, 0.04-0.3g, 0.04-0.25g, 0.04-0.2g, 0.04-0.15g, 0.04-0.1g, 0.05-0.4g, 0.05-0.3g, 0.05-0.25g, 0.05-0.2g, 0.05-0.15g, 0.05-0. It may also be 1g, 0.06~0.4g, 0.06~0.3g, 0.06~0.25g, 0.06~0.2g, 0.06~0.15g, 0.06~0.1g, 0.07~0.4g, 0.07~0.3g, 0.07~0.25g, 0.07~0.2g, 0.07~0.15g, 0.07~0.1g, 0.08~0.4g, 0.08~0.3g, 0.08~0.25g, 0.08~0.2g, 0.08~0.15g, or 0.08~0.1g.

[0062] In this specification, "adjusting the collagen-containing oral liquid composition to contain 0.04 to 0.5 g of imidazole dipeptide per 1 g of collagen" is not particularly limited as long as the amount of imidazole dipeptide in the collagen-containing liquid composition is ultimately 0.04 to 0.5 g per 1 g of collagen. Therefore, the collagen-containing oral liquid composition may be adjusted by separately adding a collagen preparation or an imidazole dipeptide preparation, or the amount of collagen and imidazole dipeptide in the final product may be adjusted by preparing the raw materials used in the production of the collagen-containing oral liquid composition.

[0063] In some embodiments of the present invention, the amount of collagen contained in the collagen-containing oral liquid composition is less than 20 g / 100 ml. In preferred embodiments of the present invention, the collagen content is 6-19 g / 100 ml, 6-18 g / 100 ml, 6-17 g / 100 ml, 6-16 g / 100 ml, 6-15 g / 100 ml, 6-14 g / 100 ml, 6-13 g / 100 ml, 6-12 g / 100 ml, 6-11 g / 100 ml, 6-10 g / 100 ml, 6 g / 100 ml or more and less than 10 g / 100 ml, 6-9 g / 100 ml, 6-8 g / 100 ml, 6-7 g / 100ml, over 6g / 100ml and less than 13g / 100ml, over 6g / 100ml and 12g / 100ml or less, over 6g / 100ml and 11g / 100ml or less, over 6g / 100ml and 10g / 100ml or less, over 6g / 100ml and less than 10g / 100ml, over 6g / 100ml and 9g / 100ml or less, over 6g / 100ml and 8g / 100ml or less, over 6g / 100ml and 7g / 100ml or less Below, 6.1g / 100ml or more and less than 13g / 100ml, 6.1~12g / 100ml, 6.1~11g / 100ml, 6.1~10g / 100ml, 6.1g / 100ml or more and less than 10g / 100ml, 6.1~9g / 100ml, 6.1~8g / 100ml, 6.1~7g / 100ml, 6.2g / 100ml or more and less than 13g / 100ml, 6.2~12g / 100ml, 6.2~11g / 100ml, 6.2~10 g / 100ml, 6.2g / 100ml or more and less than 10g / 100ml, 6.2~9g / 100ml, 6.2~8g / 100ml, 6.2~7g / 100ml, 6.5g / 100ml or more and less than 13g / 100ml, 6.5g~12g / 100ml, 6.5~11g / 100ml, 6.5~10g / 100ml, 6.5g / 100ml or more and less than 10g / 100ml, 6.5~9g / 100ml, 6.5~8g / 100ml, 6.It may be 5-7g / 100ml, 7g / 100ml or more and less than 13g / 100ml, 7-12g / 100ml, 7-11g / 100ml, 7-10g / 100ml, 7g / 100ml or more and less than 10g / 100ml, 7-9g / 100ml, 7-8g / 100ml, 8g / 100ml or more and less than 13g / 100ml, 8-12g / 100ml, 8-11g / 100ml, 8-10g / 100ml, 8g / 100ml or more and less than 10g / 100ml, or 8-9g / 100ml. The collagen content is more preferably 6-11g / 100ml, 6g / 100ml-10g / 100ml, or 6.1g / 100ml or more, and less than 10g / 100ml.

[0064] In one embodiment of the present invention, the definitions of "oral liquid composition," "collagen," "imidazole dipeptide," "chicken extract," and "other components and properties" are the same as those described in the section on oral liquid composition above.

[0065] In this specification, the phrase "at least" means that the number of a particular item may be greater than or equal to the number listed. Furthermore, in this application, the phrase "about" means that the subject lies within ±25%, ±10%, ±5%, ±3%, ±2%, or ±1% of the number following "about". For example, "about 10" means the range from 7.5 to 12.5. [Examples]

[0066] The present invention will be specifically described below with reference to examples, but the present invention is not limited to the following examples.

[0067] [Example 1] <Examples 1-1 to 1-39> An oral liquid composition was obtained by mixing the raw materials shown in Table 1 with water. The raw materials used were as follows: collagen preparation (Rousselot, "Peptan F 2000 HD", collagen purity: 90% or higher, fish-derived collagen peptide), imidazole dipeptide preparation (Lytone Enterprise, "Imida 15", anserine and carnosine purity: 15% or higher (anserine 10% or higher, carnosine 5% or higher)), and water (RO water (reverse osmosis water)). [Table 1]

[0068] The collagen content and the total content of anserine and carnosine in each sample were calculated based on the information in the Certificate of Analysis (COA), which shows the detailed content of each component for each lot of the raw materials.

[0069] The taste quality of the oral liquid compositions obtained using the above procedure was evaluated. Each sample was evaluated by three expert panelists based on the following criteria. [Table 2]

[0070] Before conducting the test, the panelists thoroughly discussed and agreed on the evaluation criteria mentioned above. The results are summarized in Table 3. The results shown in Table 3 are the average scores from the three expert panelists. Furthermore, the overall evaluation was based on the lower of the two scores obtained for "bitterness" and "unpleasant fishy smell." [Table 3]

[0071] [Example 2] <Examples 2-1 to 2-20> An oral liquid composition was obtained by mixing the raw materials shown in Table 4 with water. The raw materials used were as follows: collagen preparation (Rousselot, "Peptan F 2000 HD", collagen purity: 90% or higher, fish-derived collagen peptide), imidazole dipeptide preparation (Lytone Enterprise, "Imida 15", anserine and carnosine purity: 15% or higher (anserine 10% or higher, carnosine 5% or higher)), water (RO water (reverse osmosis water)), and trisodium citrate preparation (Jungbunzlauer Canada Inc., "Trisodium citrate dehydrate fine F60000", purity: 99% or higher). [Table 4]

[0072] The collagen content and the total content of anserine and carnosine in each sample were calculated based on the information in the Certificate of Analysis (COA), which shows the detailed content of each component for each lot of the raw materials. The sodium content in each sample was calculated by determining the amount of sodium originally contained in the collagen preparation and the imidazole dipeptide preparation based on the information in the Certificate of Analysis, and then adding the amount of sodium calculated from the amount of trisodium citrate added. The amount of sodium in the collagen preparation used in this example was 0.24% by weight, and the amount of sodium in the imidazole dipeptide preparation was 0.95% by weight.

[0073] The taste quality of the oral liquid compositions obtained using the above procedure was evaluated. Each sample was evaluated by three expert panelists based on the following criteria. A body (mouthfeel) score of 3 or higher is considered desirable. [Table 5]

[0074] Before conducting the test, the panelists thoroughly discussed and agreed on the evaluation criteria outlined above. The results are summarized in Table 6. The results shown in Table 6 represent the average of the scores given by the three expert panelists. [Table 6]

Claims

1. An oral liquid composition, Collagen that is 6g / 100ml or more and less than 20g / 100ml One or more imidazole dipeptides selected from the group consisting of anserine, carnosine, balenine, homoanserine, and homocarnosine, in a concentration of 0.35 g / 100 ml or more and less than 2.0 g / 100 ml. 50-200 mg / 100 mL of sodium and A composition containing the following:

2. The composition according to claim 1, wherein the content of one or more imidazole dipeptides is 0.35 to 1.6 g / 100 ml.

3. The composition according to claim 1, wherein the content of one or more imidazole dipeptides is 0.35 to 1.4 g / 100 ml.

4. The collagen content is 6 to 11 g / 100 ml. The composition according to claim 1, wherein the content of one or more imidazole dipeptides is 0.5 to 1.3 g / 100 ml.

5. The collagen content is 6 to 10 g / 100 ml. The composition according to claim 1, wherein the content of one or more imidazole dipeptides is 0.6 to 1.25 g / 100 ml.

6. Let Y be the collagen content (g / 100ml) and X be the total content of carnosine and anserine (g / 100ml). Then, equation (1): Y≧-17.705X+16.705 (1) The composition according to claim 3, which satisfies the requirements.

7. The composition according to claim 1, comprising anserine and carnosine.

8. The composition according to claim 1, comprising 300 to 900 mg / 100 mL of BCAA.

9. The composition according to claim 1, which is a soup in a pouch.

10. A method for improving the taste quality of a collagen-containing oral liquid composition, wherein the collagen-containing oral liquid composition contains 50 to 200 mg / 100 mL of sodium, the amount of collagen contained in the collagen-containing oral liquid composition is 6 g / 100 mL or more, and the composition is adjusted to contain 0.06 to 0.5 g of one or more imidazole dipeptides selected from the group consisting of anserine, carnosine, balenine, homoanserine, and homocarnosine per 1 g of collagen contained in the collagen-containing oral liquid composition.

11. The method according to claim 10, wherein the amount of collagen contained in the collagen-containing oral liquid composition is less than 20 g / 100 ml.

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