System and method for operating an analyte sensor electronic device

Abstract

To provide systems and methods for activating analyte sensor electronics.SOLUTION: Various analyte sensor systems for controlling activation of analyte sensor electronic circuitry and monitoring an analyte in a host are provided. Various circuits for controlling activation of an analyte sensor system are also provided. Analyte sensor systems utilizing a state machine having a plurality of states for collecting a plurality of digital counts and waking a controller in response to a wake-up signal are also provided. Related methods for such analyte sensor systems are also provided. Systems for controlling activation of analyte sensor electronic circuitry utilizing a magnetic sensor are further provided. One or more display devices configured to display one or more analyte concentration values are also provided.SELECTED DRAWING: Figure 1

Description

Technical Field

[0001] Incorporation by reference to related applications All priority claims identified in the application data sheet, or any amendments thereto, are incorporated herein by reference under 37 C.F.R. § 1.57. This application claims the benefit of U.S. Provisional Patent Application No. 62 / 666,554, filed May 3, 2018. The foregoing application is incorporated herein by reference in its entirety and is made expressly a part hereof. This development generally relates to medical devices such as analyte sensors, and more specifically, but not by way of limitation, to systems, devices, and methods for operating an analyte sensor electronics on such medical devices. [[ID=1----17]]

[0002] <00000----24]]

Background Art

[0003] Diabetes mellitus is a disease in which the pancreas cannot produce sufficient insulin (type I or insulin-dependent), and / or insulin is ineffective (type 2 or non-insulin-dependent). In a diabetic state, the victim is troubled by hyperglycemia, which is associated with many physiological disorders associated with microvascular deterioration (renal failure, skin ulcers, or bleeding into the vitreous humor of the eye). A hypoglycemic reaction can be induced by inadvertent overdose of insulin, or by normal administration of insulin or glucose-lowering drugs accompanied by abnormal exercise or insufficient food intake.

[0004] ​​​​​​​​Traditionally, people with diabetes have carried self-monitoring blood glucose (SMBG) monitors, but these have an uncomfortable finger A puncture may be necessary. Because it lacks comfort and convenience, diabetic patients usually... All you have to do is measure your glucose levels 2-4 times a day. Unfortunately, this Because the time intervals between them are very long, diabetic patients are affected by high or low blood sugar levels. The warning may come too late, potentially leading to dangerous side effects. In fact, not only is it unlikely that diabetic patients will obtain SMBG values ​​in a timely manner, but conventional methods... Due to the restriction, is your blood sugar level rising (getting higher) or falling (getting lower)? I don't know if it will happen.

[0005] As a result, a variety of non-invasive methods have been developed to continuously detect and / or quantify blood glucose levels. transdermal (for example, transcutaneous) ) and / or embedded electrochemical sensors have been developed. These devices are one Generally, for subsequent analysis on remote devices that include displays, raw data Transmit data or minimal processing data. Transmission to wireless display devices shall be wireless. This can be done. Next, the remote device provides the user with information about the user's blood glucose level. It can be provided. Systems using such embedded sensors can provide more Because it can provide users with new information, users can adjust their blood glucose levels. In particular, it can reduce the risk of failure. Nevertheless, such systems are usually For example, taking action to regulate the user's blood glucose level by administering an injection. It still relies on the user.

[0006] Such systems typically use a phosphating system to process and communicate glucose-related information. It may include a glucose sensor that can be embedded in the sensor electronic circuit. However, In such systems, sensors and sensor electronic circuits are typically embedded in the user. It is designed to be connected to only after it has been created, by a user or host. The user is involved in deploying the analyte sensor system through a pre-connected system. The amount of interaction can potentially be reduced.

[0007] This background technology is a brief description of the following invention outline and modes for carrying out the invention. Provided for introducing pulses. This background technology determines the scope of the claimed subject matter. It is also intended to assist in the claiming subject matter in the above disadvantages or problems It should not be seen as being limited to implementations that solve every conceivable problem. [Overview of the project] [Problems that the invention aims to solve]

[0008] In light of the above characteristics associated with several systems, the analyte sensor is also used by the user Before being implanted in the host, the analyte sensor and the electronic circuit of the analyte sensor are electrically connected to each other. There is a need for an analyte sensor system that is configured to be mechanically coupled. This disclosure generally relates to wireless analysis of analyte data collected using an analyte sensor system. This disclosure relates to controlling the operation of sensor electronic devices for communication. More specifically, this disclosure relates to Before the analyte sensor is embedded in the host, the analyte sensor electronic circuitry is electrically and mechanically modified. Numerous ways to control such operation in an analyte sensor system connected to both sides Systems, methods, apparatuses, and devices for using the technology of are targeted.

Means for Solving the Problem

[0009] The systems, methods, devices, and other aspects and embodiments of the present disclosure have a number of advantages. For example, an analyte sensor system configured such that the analyte sensor is connected to the analyte sensor electronic circuit before implantation may require little user interaction, be smaller, simpler, more refined, and / or less expensive, and may have fewer problems with sealing, deployment, and connection. For example, problems with connection, alignment, retention, and separation of the analyte sensor related to the connection of the analyte sensor during percutaneous implantation can be avoided. As a further example, in systems that are not designed to be pre-connected, when the analyte sensor and the analyte sensor electronic circuit are joined in the field, it may be necessary to create a seal between the analyte sensor electronic circuit and the analyte sensor and / or their housings. However, in a pre-connected system, this seal can be performed during system manufacture. Therefore, malfunctions that may occur as a result of the insertion of the analyte sensor can be avoided. Another exemplary advantage of a pre-connected system is that it may be advantageous for the analyte sensor system to transition to an active state so that the analyte sensor captures analyte measurements shortly before being implanted by the user. This allows the analyte processing algorithm to more accurately evaluate the sensor implantation time, enabling more accurate processing of the analyte value of the sensor signal. For example, an analyte sensor system configured such that the analyte sensor is connected to the analyte sensor electronic circuit before implantation may require little user interaction, be smaller, simpler, more refined, and / or less expensive, and may have fewer problems with sealing, deployment, and connection. For example, an analyte sensor system configured such that the analyte sensor is connected to the analyte sensor electronic circuit before implantation may require little user interaction, be smaller, simpler, more refined, and / or less expensive, and may have fewer problems with sealing, deployment, and connection. For example, an analyte sensor system configured such that the analyte sensor is connected to the analyte sensor electronic circuit before implantation may require little user interaction, be smaller, simpler, more refined, and / or less expensive, and may have fewer problems with sealing, deployment, and connection. For example, an analyte sensor system configured such that the analyte sensor is connected to the analyte sensor electronic circuit before implantation may require little user interaction, be smaller, simpler, more refined, and / or less expensive, and may have fewer problems with sealing, deployment, and connection. For example, problems with connection, alignment, retention, and separation of the analyte sensor related to the connection of the analyte sensor during percutaneous implantation can be avoided. For example, problems with connection, alignment, retention, and separation of the analyte sensor related to the connection of the analyte sensor during percutaneous implantation can be avoided. For example, problems with connection, alignment, retention, and separation of the analyte sensor related to the connection of the analyte sensor during percutaneous implantation can be avoided. In a system that is not designed to be pre-connected, when the analyte sensor and the analyte sensor electronic circuit are joined in the field, it may be necessary to create a seal between the analyte sensor electronic circuit and the analyte sensor and / or their housings. In a system that is not designed to be pre-connected, when the analyte sensor and the analyte sensor electronic circuit are joined in the field, it may be necessary to create a seal between the analyte sensor electronic circuit and the analyte sensor and / or their housings. However, in a pre-connected system, this seal can be performed during system manufacture. Therefore, malfunctions that may occur as a result of the insertion of the analyte sensor can be avoided. Another exemplary advantage of a pre-connected system is that it may be advantageous for the analyte sensor system to transition to an active state so that the analyte sensor captures analyte measurements shortly before being implanted by the user. Another exemplary advantage of a pre-connected system is that it may be advantageous for the analyte sensor system to transition to an active state so that the analyte sensor captures analyte measurements shortly before being implanted by the user. Another exemplary advantage of a pre-connected system is that it may be advantageous for the analyte sensor system to transition to an active state so that the analyte sensor captures analyte measurements shortly before being implanted by the user. This allows the analyte processing algorithm to more accurately evaluate the sensor implantation time, enabling more accurate processing of the analyte value of the sensor signal.

[0010] Also, several related to implementing a pre-connected analyte sensor system This could also present a challenge. For example, in a system that is not pre-connected, the analyte sensor may be inside the circuit. By monitoring the analyte sensor electronic circuit for electrical signals indicating the presence of the substance, The analyte sensor system may be activated. However, in a pre-connected system, Signals like these can be susceptible to noise, potentially leading to incorrect triggering / operation of the system. It may be possible to connect. In addition, monitoring of the analyte sensor before implantation is desired for the analyte sensor. This could lead to undesirable changes (e.g., deviations from calibration values). Therefore, Monitoring the analyte sensor electronic device for the analyte sensor signal only is in certain cases Therefore, it may not be very suitable as the primary or sole means for the purpose of operation. ru.

[0011] Therefore, alternative and / or additional means are used to operate the analyte sensor system. This is possible. However, such methods are not robust against false wake-up events. It should be done, accurate analyte sensor calibration should be maintained, and it should not consume a large amount of power. Instead, it should allow for a sufficiently rapid wake-up of the analyte sensor system. In addition, pre-connected systems, for example, can handle user steps associated with the connection. Reduce and / or eliminate and / or combine incompatible sensors and electronic devices. By reducing and / or eliminating possibilities, we can improve the user experience. It should be provided. Furthermore, for example, pre-connected systems and solutions are available for analysis. Closed-loop systems that can lead to a reduction in data loss (e.g., automated insulin delivery systems) , and related or similar systems and applications) and connections (e.g., without This can make the initiation of (wire connection) faster and easier. Also, healthcare provider scenarios (examples) For example, doctors or other clinics may need to consider the time required to set up such a system. (For example, for implanting sensors in the user's body, and / or for analyte sensor electronic devices) The time required to activate or establish the operation of the device can be substantially reduced.

[0012] Embodiments of this disclosure detect and confirm the conditions for operating an analyte sensor electronic circuit. By employing a variety of methods, these challenges can be overcome, and the aforementioned advantages can be provided. By using one or more verification methods, embodiments of the present disclosure can prevent false wake-ups. In contrast, it provides a more robust system, thus saving power and resulting in a better overall system. It provides reliability and the other advantages mentioned above. According to embodiments of this disclosure, To implement a robust wake-up or activation procedure, and to prevent incorrect wake-up events To avoid this, use multiple indicators for inserting the analyte sensor. The electronic circuit can be triggered to terminate the lower power state. In many embodiments, The system largely avoids altering the characteristics of the analyte sensor, and the embedded analyte sensor Signal noise that may be experienced beforehand (for example, that may result from humidity, temperature, vibration, etc.) To be robust against and to operate in a manner suitable for low-power battery-powered devices. , designed.

[0013] Regarding numerous techniques that can be used to detect operational events in analyte sensor electronic circuits Generally, such technologies can be divided into those that utilize primary signals and those that utilize secondary signals. They can be separated. As referred to herein, the primary signal is generally obtained using an analyte sensor. Related to the analyte information obtained from the host, correlated with, derived from, and characterizing, and / or may relate to the signal being described. As referred to herein, a secondary signal is Generally, this may relate to information collected using an analyte sensor system, and the collected information is , information other than the primary signal (single or multiple) (for example, collected information is separate from the signal) (This information is not used in the primary signal capacitance to describe the relationship with the precipitate information.) Secondary signal Alternatively, the information can be obtained using an analyte sensor (e.g., one or more electrodes) and / or other means. They may be collected in this manner. Other such means are described in more detail herein. Thus, the circuitry inside or outside the analyte sensor system It may include components. In addition, secondary signals or information may be included in the analyte sensor system. The call and / or use of external components alone or in conjunction with user interaction. It may be collected using this method.

[0014] For example, one technique can be used to control another technique that may be affected by noise or false triggers. It can be checked, for example, using one or more primary signals and one or more secondary signals To check, it is possible to detect the activation event of the electronic circuit of the analyzer sensor. Combining numerous techniques that can be used makes the system robust against false wake-ups. The robustness can be increased. In some cases, the primary signal (e.g., voltage, current, The analyte value or signal (such as a count or other signal, which may be its representative value) is analyzed. Collected using object sensor signals (e.g., impedance, capacitance of the analyte sensor, etc.) / Can be used in combination with a secondary signal that can be derived. In some cases the primary signal is , not derived / collected using means other than the analyte sensor, or means added to the analyte sensor. It can be used in combination with one or more secondary signals. In the embodiment, the primary signal information is secondary The secondary signal information can be combined with signal information, and the secondary signal information can be combined with one or more non-analyzable sensor signals. or may be information or may include such information. In one embodiment, an analyte sensor system This involves the primary signal(s) and / or derived using the analyte sensor. This includes secondary signals (one or more) and means other than the analyte sensor (for example, as specified herein). Information collected / derived using accelerometer signals or other methods, as described above. It can be used and for the purpose of operating the analyte sensor system for one or more periods of time. The aforementioned can be compared. In this way, embodiments of the present disclosure demonstrate battery efficiency It maintains high, lower power modes and robust sensor performance while providing a more accurate operating time. Accurately evaluate and / or prevent false wake-ups in pre-connected analyte sensor systems. This can be better avoided and / or reduced.

[0015] A first aspect of this disclosure includes a system for controlling the operation of an analyte sensor electronic circuit. This system electrically supplies the analyte sensor electronic circuitry before transitioning the system to the operating state. and includes a mechanically coupled analyte sensor. The analyte sensor electronic circuit has several moving It is adapted to perform the operation. One such operation allows the system to operate in a lower power state. The objective is to trigger a display to terminate the process and transition to the operating state. This display indicates the system It is triggered based on a threshold associated with the expansion of the element. Another such behavior is displayed In response, the analyte sensor is instructed to collect information related to the level of the analyte within the host. The goal is to generate control signals that can be operated in a manner that allows for such operation. Another such operation is: The objective is to generate a comparison between information and conditions related to the level of the analyte within the host. The stem is triggered when the display is activated and the level of analytes in the host meets the conditions. The comparison shows that, based on this, the lower power state is terminated and the operating mode is transitioned. ru.

[0016] While generally applicable, it is particularly applicable in relation to any other implementation of the first embodiment. In a specific implementation of the first embodiment, which is also possible, the analyte sensor electronic circuit has a threshold of less The system is also instructed to trigger a display in response to a condition being met for a predetermined amount of time. It is further adapted to this.

[0017] While generally applicable, it is particularly applicable in relation to any other implementation of the first embodiment. In a specific implementation of the first aspect, which is also possible, the display is based on the insertion of the analyte sensor into the host and An action detection circuit and action detection circuit adapted to detect one or more of the system's deployments. It is a signal generated using one or more of the components.

[0018] While generally applicable, it is particularly applicable in relation to any other implementation of the first embodiment. In a specific implementation of the first embodiment, which is also possible, the control signal is a voltage bias to the analyzer sensor. By having a potentiostat apply the solution, the level of the analyte in the host can be measured. This is a signal that can be operated to cause the analyzer sensor to collect information related to the substance.

[0019] While generally applicable, it is particularly applicable in relation to any other implementation of the first embodiment. In a specific implementation of the first aspect, which is also a function, after the system transitions to an operating state, the system The system continues to collect information related to the level of the analytes within the host, and the information is collected one by one. Communicates with the display device above or one or more partner devices.

[0020] While generally applicable, it is particularly applicable in relation to any other implementation of the first embodiment. In a specific implementation of the first aspect, which is also a function, the threshold is typically a known value present in the human host. This relates to the level of the analyte.

[0021] While generally applicable, it is particularly applicable in relation to any other implementation of the first embodiment. In a specific implementation of the first aspect, which is also functional, the display is (1) the analyzer sensor electronic circuit and base (2) the detected proximity to the quasi-object, and (3) the temperature monitored using the analyte sensor electronic circuit. (3) Output of the accelerometer of the analyte sensor electronic circuit, (4) By the analyte sensor electronic device (5) Responses generated using transmitted or received wireless signaling, analyte sensor (6) Changes detected by the electronic circuit of the pressure, measured by the electronic circuit of the analyte sensor (7) Audio information monitored, in response to photons detected by the analyzer sensor electronic circuit (8) Signal generated by the analyte sensor electronic circuit Conductivity measured between the sub-sub A mechanical switch located inside, (10) component, and the movement of the component The analyte sensor electronic circuit is adapted to change the connection between two conductive elements in response to the sensor. (11) components, and (11) generated using one or more of the measured strains It can be done.

[0022] While generally applicable, it is particularly applicable in relation to any other implementation of the first embodiment. In a specific implementation of the first aspect, which is also a function, the system is such that the level of analysis within the host is Based on the determination that the threshold has been exceeded, the lower power state is terminated.

[0023] While generally applicable, it is particularly applicable in relation to any other implementation of the first embodiment. In a specific implementation of the first aspect, which is also possible, the analyte sensor electronic circuit is programmed The system is instructed to trigger a display in response to the fulfillment of a specified period of time. It is further adapted to this.

[0024] While generally applicable, it is particularly applicable in relation to any other implementation of the first embodiment. In a specific implementation of the first aspect, which is also a function, information related to the level of the analyte within the host is available. This is used to generate the detected count. Furthermore, the condition is the threshold for the count. Includes characteristics. If the comparison indicates that the detected count has reached a threshold, the system Then, it exits the lower power state and transitions to the operating mode.

[0025] A second aspect of this disclosure includes a method for controlling an analyte sensor electronic circuit. The analyte sensor electronic circuit uses one or more of the analyte sensor and secondary sensors. This method includes acquiring the first signal that is generated. This method is performed by an analyzer sensor electronic circuit. Based on the first signal obtained, it is determined whether the first condition has been met. This method also includes, in response to the first condition being met, the analyte sensor This includes an electronic circuit activating an analyte measurement circuit. In addition, this method involves an analyte measurement circuit. The process includes using an analyte sensor to collect information related to analyte values ​​within the host. The analyte sensor is connected to the analyte sensor electronic device before the analyte sensor is implanted in the host. Combined. This method also involves the analyte sensor electronic circuit receiving information related to the analyte value in the host. This includes determining whether the report satisfies the second condition.

[0026] In addition, the method according to the second embodiment provides information related to the analyte values ​​in the host that meets the second condition. In response to the analyte sensor electronic circuit determining that it has achieved the objective, the sensor electronic circuit then... This includes terminating the low power consumption mode. Alternatively, the method involves analyzing the host The analyte sensor electronic circuit determines that the information related to the value does not satisfy the second condition. In response, the analyte sensor electronic circuit remains in a lower power consumption mode, and the first condition is This includes obtaining a second electrical signal indicating whether or not it has been achieved.

[0027] While generally applicable, it is particularly applicable in relation to any other implementation of the second embodiment. In a specific implementation of the second aspect, which is also a function, the level of the analyte value in the host meets the threshold. The second condition is met if the information related to the analyte value indicates that this is the case.

[0028] While generally applicable, it is particularly applicable in relation to any other implementation of the second embodiment. In a specific implementation of the second aspect, which is also possible, the first condition is that the analyte electrons relative to the reference point Indicates proximity of circuits.

[0029] While generally applicable, it is particularly applicable in relation to any other implementation of the second embodiment. In a specific implementation of the second aspect, which is also possible, the first condition is detected using an accelerometer. This represents the level of acceleration.

[0030] While generally applicable, it is particularly applicable in relation to any other implementation of the second embodiment. In a specific implementation of the second aspect, which is also possible, the first condition is that the accelerometer measures It relates to one or more electrical characteristics.

[0031] A third aspect of this disclosure includes a system for monitoring analytes within a host. This includes an analyte sensor. The analyte sensor provides information related to the level of analyte within the host. The system includes one or more electrodes adapted for collection. The system also includes an analyte sensor that is phosphating The sensor electronic circuitry, which is mechanically and electrically coupled to the analyte sensor before being embedded in the torch. Includes. The sensor electronic circuit meets the first condition and has at least two of one or more electrodes. The measured values ​​of the electrical signals passing through are used to create a secondary indicator. The sensor electronic circuit is related to the second condition and the level of the analyte in the host. In response to generating confirmation of a secondary indicator using the information, the active state It is further adapted to allow the system to perform the transition to the state.

[0032] While generally applicable, it is particularly applicable in relation to any other implementation of the third aspect. In a specific implementation of the third aspect, which is also possible, the sensor electronic circuit is one of the electrodes Using measurements of the electrical signal passing between at least two of them, associated with one or more electrodes Determine one or more of the impedance, capacitance, voltage, and current. It is further adapted to this.

[0033] A fourth aspect of this disclosure includes a system for monitoring analytes within a host. The system includes an analyte sensor electronic circuit. The system is an analyte sensor, and the analyte sensor The analyte sensor was mechanically and electrically coupled to the electronic circuitry before being implanted in the host. The system further includes an analyte sensor. In addition, the system includes an action detection timer coupled to the analyte sensor. The circuit includes the operation detection circuit to obtain information related to the level of the analyte within the host. It is adapted to generate control signals that can be operated by the analyte sensor. The signal is generated in response to an electrical signal indicating that the first condition is met. The sensor electronic circuit operates when the level of the analyte in the host satisfies the second condition, If an electrical signal indicates that the first condition is met, the system will change its state. It will be adapted so that it is performed by the system.

[0034] While generally applicable, it is particularly applicable in relation to any other implementation of the fourth aspect. In a specific implementation of the fourth aspect, which is also a function, the indication that the first condition is met is: It is generated using one or more of the following: parameters, inputs, and / or variables. For example Any of the following may be used, either alone or in combination, to generate the display. The display is generated using the detected proximity between the analyte sensor electronic circuit and the reference object. It may be done. The display is generated using the temperature monitored by the analyte sensor electronic circuit. This may also be generated using the output of the accelerometer of the analyte sensor electronic circuit. Good. In the embodiment, the display is wirelessly transmitted or received by the analyte sensor electronic device. It may be generated using a response generated using signaling. Furthermore, the display is Even if generated using the detected change in atmospheric pressure measured by the analyte sensor electronic circuit Good. Also, use audio information that can be monitored by the analyte sensor electronic device to generate a display. It may be done. In addition, the display responds to photons detected by the analyte sensor electronic circuit. Furthermore, it may be generated using a signal produced by the analyte sensor electronic circuit. Even if the conductivity measured between two terminals of the analyte sensor electronic circuit is used to generate a display, Good. In some cases, the display is on the housing of the analyte sensor electronic circuit or housing. It may be generated using a mechanical switch located within the ring. In this embodiment, the display is In response to the movement of the component, the connection between two conductive elements of the analyte sensor electronic circuit is It may be generated using components adapted to change. The display is measured It can be generated using the distortion that is applied.

[0035] A fifth aspect of this disclosure includes a system for monitoring analytes within a host. The system includes an analyte sensor electronic circuit. The system has the analyte sensor embedded in the host. The system further includes an analyte sensor adapted to be coupled to the analyte sensor electronic circuit beforehand. In addition, the system includes an action detection circuit coupled to the analyte sensor. The action detection circuit is The analyte sensor is coupled, and the secondary sensor is monitored according to the sampling frequency. Then, the sampling frequency is increased in response to the first event detected using the secondary sensor. The operation detection circuit is adapted to perform the increased sampling frequency. The system monitors secondary sensors according to the number of events and controls them in response to detecting a second event. It is further adapted to generate signals and perform other actions. The control signal is used by the analyzer sensor. When embedded in a device, it performs measurements to obtain information indicating the level of the analyte within the host. It is operable to have the analyte sensor perform this action. The analyte sensor electronic circuit is phosph Information indicating the level of the analyte within the sample responds to the condition being met, and the operation is detected. The system changes its state in response to detecting a second event. It will be further adapted to allow the operation to be performed by M.

[0036] While generally applicable, it is particularly applicable in relation to any other implementation of the fifth aspect. In a specific implementation of the fifth aspect, which is also a function, the sampling frequency is the operation detection component. One or more of the first and second events determined by Nent Therefore, it is set.

[0037] A sixth aspect of this disclosure includes a circuit for controlling the operation of an analyte sensor system. The path is adapted to indicate whether the signal at the input terminal of the detection circuit meets the condition. Includes a detection circuit. The detection circuit indicates that the signal has met the conditions. In addition, further modifications are made to trigger the analyzer system to terminate the lower power state. The circuit also controls the coupling between the input terminal of the detection circuit and the first terminal of the analyte sensor. Includes a first switch element adapted for control. The analyte sensor detects the analyte within the host. The circuit is adapted to collect level-related information. The first end of the analyzer sensor A second saturator adapted to control the coupling between the child and the first terminal of the potentiostat. It further includes an switch element. The potentiostat relates to the level of the analyte within the host. A voltage bias is applied to the analyzer sensor to cause it to collect information. It is suitable. The input terminal of the detection circuit is connected to the second terminal of the analyte sensor, and the potentiometer It is coupled to the second terminal of the iostat. The circuit is connected to the first analyte sensor at the first time point. The second switching element is made to connect the terminal of the first switch to the first terminal of the potentiostat. Furthermore, the input terminal of the detection circuit is separated from the first terminal of the analyte sensor by the first switch. This includes the process of operating the analyzer sensor system by having the element perform the operation. It is adapted to generate additional detectable events. At the second point, the circuit analyzes the analyte. The second switch separates the first terminal of the sensor from the first terminal of the potentiostat. This is done by a chrysocollidant element, and the input terminal of the detection circuit is connected to the first terminal of the analyte sensor. It is adapted to be performed by the first switching element.

[0038] While generally applicable, it is particularly applicable in relation to any other implementation of the sixth aspect. In a specific implementation of the sixth aspect, which is also possible, the circuit also has an input terminal for the detection circuit and a second Includes a capacitive element coupled to a reference voltage.

[0039] While generally applicable, it is particularly applicable in relation to any other implementation of the sixth aspect. In a specific implementation of the sixth aspect, which is also possible, the second switching element is at the input terminal of the detection circuit. The child is adapted to be coupled to the first terminal via a resistive element.

[0040] While generally applicable, it is particularly applicable in relation to any other implementation of the sixth aspect. In a specific implementation of the sixth aspect, which is also possible, the circuit uses the input terminal of the detection circuit as a second reference. The invention further includes a third switching element adapted to couple to a voltage.

[0041] While generally applicable, it is particularly applicable in relation to any other implementation of the sixth aspect. In a specific implementation of the sixth aspect, which is also a function, the third switching element is the input terminal of the detection circuit. When coupled to a second reference voltage, the capacitive element discharges.

[0042] While generally applicable, it is particularly applicable in relation to any other implementation of the sixth aspect. In a specific implementation of the sixth aspect, which is also a capability, the terminals of the third switching element are of the detection circuit The third switching element is used to periodically couple the input terminal to a second reference voltage. It will be joined to the .

[0043] While generally applicable, it is particularly applicable in relation to any other implementation of the sixth aspect. In a specific implementation of the sixth aspect, which is also a function, the first switching element is controlled by a common signal. The first switch element is driven, and the second switch element is driven by an inverted version of the common signal.

[0044] While generally applicable, it is particularly applicable in relation to any other implementation of the sixth aspect. In a specific implementation of the sixth aspect, which is also a function, the first switch element and the second switch The elements are driven by a common signal and have opposite polarity.

[0045] While generally applicable, it is particularly applicable in relation to any other implementation of the sixth aspect. In a specific implementation of the sixth aspect, which is also a function, the voltage at the input terminal of the detection circuit is analyzed. When the object sensor is embedded in the host, the first terminal of the analyte sensor and the analyte sensor This shows the current between the second terminal and the second terminal.

[0046] While generally applicable, it is particularly applicable in relation to any other implementation of the sixth aspect. In a specific implementation of the sixth aspect, which is also possible, the reference terminal of the detection circuit is connected to the first reference voltage. They are coupled. The detection circuit includes a comparator.

[0047] While generally applicable, it is particularly applicable in relation to any other implementation of the sixth aspect. In a specific implementation of the sixth aspect, which is also a function, the second voltage reference is ground.

[0048] In some embodiments, an analyte sensor system is provided. The system includes an analyte sensor. The analyte sensor system performs a first sampling during the first sampling state. The potential is applied between both ends of the analyte sensor, and the second sampling The state is configured such that a second potential is applied between both ends of the analyte sensor during that state. Includes a state machine. The analyzer sensor system applies a first sample based on the application of a first potential. During the state, a first digital count is generated corresponding to the first current flowing through the analyzer sensor. , and based on the application of the second potential, the analyte sensor is subjected to the second sampling state. Analytical sensor measurement configured to generate a second digital count corresponding to 2 currents Includes a constant circuit. The analyte sensor system includes a second digital count and a first digital count. Determine the first difference between and the threshold, and in response to at least the first difference that satisfies the threshold, Includes a detection circuit configured to generate a controller wake-up signal. The system has at least a first sampling state, a second sampling state, and a third During the duration of the difference determination, enter a lower power state, and the controller wave A device configured to transition from a lower power state to an operating state in response to an upgrade signal. The controller includes the first difference, at least partially, of the analyte. It is configured to determine the impedance of the sensor.

[0049] In some embodiments, the state machine is a first delayed state immediately preceding a first sample state. It is configured to trigger the initiation of a first potential applied between both ends of the analyte sensor. Therefore, the analyzer sensor measurement circuit suspends the generation of digital counts during the first delay state. It is configured in such a way.

[0050] In some embodiments, the state machine is a second delayed state immediately preceding a second sample state. It is configured to trigger the initiation of a second potential applied between both ends of the analyte sensor. Therefore, the analyzer sensor circuit will suspend the generation of digital counts during the second delay state. It is composed of sea urchin.

[0051] In some embodiments, the state machine has a third delay that follows the second sampling state. During this state, the sensor is configured to have a zero potential applied between both ends of the analyte sensor. The analyzer sensor measurement circuit then suspends the generation of digital counts during the third delay state. It is configured in this way.

[0052] In some embodiments, the detection circuit is configured to store a first digital count. It includes a first sample buffer. In some embodiments, the detection circuit includes the first sample buffer. The first digital count is received from the sample buffer, and the second digital count is received from the analyzer sensor measurement circuit. Includes a differencer configured to receive two digital counts and determine a first difference. nothing.

[0053] In some embodiments, the detection circuit includes a first difference and at least a third digital cow The product configured to generate the sum of the second difference between the t and the fourth digital count, and Includes a calculator. The third digital count is calculated in minutes during the subsequent stages following the first sampling state. Corresponding to the third current flowing through the precipitate sensor, the fourth digital count corresponds to the second sampler. This corresponds to the fourth current flowing through the analyte sensor during the subsequent stages of the state. In this configuration, the detection circuit checks if the sum of at least the first difference and the second difference satisfies the threshold. It is configured to generate a controller wake-up signal in response to this.

[0054] In some embodiments, the controller transitions to a lower power state before the state machine It is configured to define at least one parameter of the form. In some embodiments, In the first operating mode of the analyte sensor system, the first potential is zero volts, and the second The potential of the first potential is greater by a predetermined amount, and the second operating mode of the analyte sensor system In this case, the first potential is between the ends of the analyte sensor to determine the concentration of the analyte in the host. The applied potential is the same, and the second potential is greater than the first potential by a predetermined amount.

[0055] In some embodiments, methods for controlling an analyte sensor system are provided. This method utilizes a state machine to determine the potential of the analyte sensor during the first sampling state. The second potential is applied between both ends of the voltage, and during the second sampling state, the second potential is analyzed. This method includes applying the sensor between both ends of the object sensor. Using the circuit, the analyzer sensor is subjected to a first sampling state based on the application of a first potential. A first digital count is generated corresponding to the first current flowing, and a second potential is applied. Based on this, during the second sampling state, the second current flowing through the analyte sensor corresponds to the second This method generates a digital count using a detection circuit to generate a second digital count. Determine the first difference between the marker and the first digital count, and at least the first difference This includes generating a controller wake-up signal in response to a threshold being met. This method involves at least a first sampling state, a second sampling state, and a first During the duration of the difference determination, transition to a lower power state and the controller way In response to the quake-up signal, it transitions from a lower power state to an operating state, and the first difference Determining the impedance of the analyte sensor based at least partially on this, and controlling This includes having Laura do it.

[0056] In some embodiments, this method involves a first delayed state immediately preceding the first sample state. Between the application of the first potential to both ends of the analyte sensor and the first delay state This includes interrupting the generation of digital counts by the analyte sensor measurement circuit.

[0057] In some embodiments, this method involves a second delayed state immediately preceding the second sample state. Between the application of a second potential across both ends of the analyte sensor and the second delay state This includes interrupting the generation of digital counts by the analyte sensor measurement circuit.

[0058] In some embodiments, this method utilizes a state machine to perform a second sample state after During the subsequent third delay state, a zero potential is applied between both ends of the analyte sensor. During the third delay state, the generation of digital counts by the analyte sensor measurement circuit is interrupted. This includes the act of doing something.

[0059] In some embodiments, this method determines the first digital difference before determining the first difference. This includes storing the data in a first sample buffer. In some embodiments, this The method involves receiving a first digital count from a first sample buffer using a differencer. This involves receiving a second digital count from the analyte sensor measurement circuit using a differencer. This includes determining the first difference using a differencer.

[0060] In some embodiments, this method utilizes an integrator to calculate the first difference and at least Generate the sum of the second difference between the third digital count and the fourth digital count. This includes the fact that the third digital count is generated during the subsequent stages of the first sampling state. Corresponding to the third current flowing through the precipitate sensor, the fourth digital count corresponds to the second sampler. This corresponds to the fourth current flowing through the analyzer sensor during the subsequent stages of the state.

[0061] In some embodiments, this method is such that the sum of at least the first difference and the second difference is In response to the threshold being met, a controller wake-up signal is generated. include.

[0062] In some embodiments, this method utilizes a controller to lower power states. This includes defining at least one parameter of the state machine before transitioning.

[0063] In some embodiments, in the first operating mode of the analyte sensor system, the first potential However, it is zero volts, and the second potential is a predetermined amount greater than the first potential, and the analyte sensor In the second operating mode of the system, the first potential is used to determine the concentration of the analyte in the host. Therefore, the second potential is the same as the potential applied between both ends of the analyzer sensor, and the second potential is the same as the first potential. It is only slightly larger by a predetermined amount.

[0064] In some embodiments, a system for controlling the operation of the analyte sensor electronic circuit is provided. The system is provided with an analyte sensor and a magnetic sensor, wherein the magnet is sufficient for the magnetic sensor. A magnetic sensor configured to trigger a wake signal in response to being brought close, and In response to the wake signal, it terminates the lower power state and transitions to the operating state, and the operating state In response to the transition, receive a display of one or more analyte concentration values ​​from the analyte sensor. Includes an analyte sensor electronic circuit configured as such.

[0065] In some embodiments, the magnet is configured to display one or more analyte concentration values. It is placed on a display device. In some embodiments, the magnetic sensor is located on the magnetic sensor. In contrast, the magnet is moved in at least one of a predetermined motion and a predetermined spatial orientation. It is configured to respond by triggering a wake signal.

[0066] In some embodiments, a display device configured to show one or more analyte concentration values A vise is provided. The display device is used while deploying the analyte sensor system. A microphone configured to generate one or more audio waveforms of the sound emitted by a microphone. Includes. The display device is applied while the applicator is deploying the analyte sensor system. Includes a processor configured to run an application. Analyzes the above audio waveform and analyzes one or more audio waveforms based on the analysis of the analyzer sensor The system is configured to identify either a successful or failed deployment. The device indicates a successful deployment, responding to the application identifying a successful deployment. The first display and the failed deployment in response to the application identifying the failed deployment A display configured to show at least one of the following: , including.

[0067] In some embodiments, analyzing one or more audio waveforms is a less complex application. At least one or more audio waveforms that indicate performing known movements of a successful deployment This includes identifying at least a part of it.

[0068] This abstract is intended to provide an overview of the subject matter of this patent application. It is not intended to provide a comprehensive description. A detailed description is provided in relation to this patent application. This is included to provide further information. Other aspects of this disclosure are described in detail below. It will be obvious to a person skilled in the art if they read and understand it, and if they look at the drawings that form that part, and each of them is, It should not be interpreted in a limited sense. [Brief explanation of the drawing]

[0069] Further aspects of this disclosure, in conjunction with the attached drawings, are described below in various ways. A detailed description of the embodiments will make it easier to understand.

[0070] [Figure 1] This shows exemplary systems that may be used in relation to several embodiments. [Figure 2] This shows exemplary systems that may be used in relation to several embodiments. [Figure 3A] This is an exemplary analyte sensor system according to several embodiments. [Figure 3B] This is an exemplary analyte sensor system according to several embodiments. [Figure 4] Several embodiments of exemplary analyte sensor systems are shown. [Figure 5] Several embodiments of exemplary analyte sensor systems are shown. [Figure 6A] This document illustrates exemplary application devices according to several embodiments. [Figure 6B] Another diagram of an exemplary application device according to several embodiments is shown. [Figure 6C] The following describes exemplary embodiments of an action detection component according to several embodiments. [Figure 6D] The following are exemplary top views of connectors according to several embodiments. [Figure 6E] The following shows a top view of another exemplary connector according to several embodiments. [Figure 7A] Exemplary circuit diagrams of analyte sensors according to several embodiments are shown. [Figure 7B] Exemplary plots of the analyte sensor impedance as a function of time are shown for several embodiments. [Figure 7C]Exemplary plots of the analyte sensor impedance as a function of time are shown for several embodiments. [Figure 8A] The following describes exemplary operational detection circuits according to several embodiments. [Figure 8B] Exemplary plots of analyte sensor signals from several embodiments are shown. [Figure 8C] This is an operation flow diagram illustrating various operations that can be performed according to several embodiments. [Figure 9] The following are exemplary plots illustrating the operation of exemplary analyte sensor systems according to several embodiments. [Figure 10] This is an operation flow diagram illustrating various operations that can be performed according to several embodiments. [Figure 11] This document illustrates exemplary computing modules in several embodiments. [Figure 12] Timing diagrams related to state machines for ultimately determining the impedance of the analyte sensor are shown in several embodiments. [Figure 13] The diagrams shown are phase diagrams related to a state machine for ultimately determining the impedance of an analyte sensor, according to several embodiments. [Figure 14] The following are functional block diagrams relating to a state machine for ultimately determining the impedance of an analyte sensor, according to several embodiments. [Figure 15] A flowchart illustrating a method for controlling an analyte sensor system according to several embodiments is shown. [Modes for carrying out the invention]

[0071] The drawings are described in more detail in the following description and examples and are provided for illustrative purposes only. The drawings merely illustrate typical or exemplary embodiments of the present disclosure. The drawings are exhaustive. This disclosure is not intended to limit the disclosure to the form in which it is disclosed. This disclosure may be implemented with modifications or changes, and the claims and equivalents thereof are included. It should be understood that this may be limited only by the object itself.

[0072] Embodiments of this disclosure relate to systems, methods, and devices for wireless communication of analyte data. This applies to the following applications. In the various applications described herein, the analyte data is displayed on the display device. , partner devices (e.g., medical devices such as insulin pumps), other remote connections Generated by an analyte sensor system configured to connect to a compatible device, etc. This is glucose data obtained from the components of the analyte sensor system. More specifically, it is obtained from the components of the analyte sensor system. Failure to perform any other unwanted operation, wake-up, and / or related actions The system described herein provides increased robustness against changes in state or other conditions. By implementing aspects of this disclosure, including methods, apparatus, and devices, a display device can be created. Chair, one or more partner devices, and / or other (e.g., electronic) devices and This can improve the accuracy, robustness, and / or power management of linearly communicating analyte sensor systems. Furthermore, by implementing the embodiments of this disclosure, the lifespan and usefulness of the analyte sensor system can be improved. It may also be possible to improve performance in terms of sexual characteristics.

[0073] Details of some exemplary embodiments of the systems, methods, and devices of this disclosure are provided below. In some cases, this is described in other parts of the disclosure. Other features of the disclosure, The purpose and benefits are as described in this disclosure, description, drawings, examples, and claims. This will become clear to those skilled in the art. Such additional systems, methods, and devices All features and benefits are included (expressly or by reference) in this description and in this disclosure. It falls within the scope and is intended to be protected by one or more of the attached claims. It is being done.

[0074] System overview and illustrative configuration Figure 1 shows information regarding the values ​​of analytes present in the user's body, including, for example, the user's blood glucose level. Used in connection with embodiments of this disclosure that involve collecting, monitoring, and / or providing information This depicts a possible system 100. System 100 includes display devices 110, 120, 130, and 140, partner device 136, and / or server system 134 This depicts an embodiment of an analyte sensor system 8 that can be communicatively coupled to a device.

[0075] The analyte sensor system 8 in the shown embodiment includes a sensor electronic module 12 and Includes an analyte sensor 10 associated with a sensor electronic module 12. The electronic module 12 is configured to allow the analyte sensor 10 to be embedded in the user or host for a minute. The analyte sensor 10 can be electrically and mechanically coupled. Therefore, the analyte sensor 10 The user is required to connect the analyte sensor electronic module 12 to the analyte sensor 10. It is not necessary. For example, the analyte sensor electronic module 12 is manufactured with the analyte sensor 10 They may be physically / mechanically and electrically coupled, and this physical / mechanical and electrical coupling The continuation is maintained during the shipment, storage, insertion, use, and removal of the analyte sensor system 8. Good. Therefore, the electromechanically connected components of the analyte sensor system 8 ( For example, the analyte sensor 10 and the analyte sensor electronic module 12 are "pre-connected It can be called a "system". The analyte sensor electronic module 12 is a display device 110, Wireless communication (e.g., directly or indirectly) with one or more of 120, 130, and 140 (Possibly) possible. In addition to display devices 110, 120, 130, and 140, or so Instead, the analyte sensor electronic module 12 is partner device 136 and / or It can communicate wirelessly with the server system 134 (e.g., directly or indirectly). Similarly, In some examples, display devices 110-140 are additional or alternative to partner devices. Wireless communication (e.g., directly or between) with Vice 136 and / or Server System 134 (Indirectly) it is possible. The various couplings illustrated in Figure 1 are, as will be mentioned below, wireless active This can be simplified using Sethpoint 138.

[0076] In certain embodiments, the analyte sensor electronic module 12 provides analyte sensor data / information Analyte sensor data, including predictive algorithms associated with processing and / or calibration. Includes electronic circuits associated with measuring and processing data or information. Analysis The material sensor electronic module 12 can be physically / chemically connected to the analyte sensor 10. The analyte sensor 10 is integrated (non-removable) or removable. It is possible to do so. The analyte sensor electronic module 12 also has components that are electrically connected to each other. The analyte sensor 10 can be electrically coupled in a manner that allows for pneumatic coupling. The Electron Module 12 includes an analyte sensor 10 (which may be, for example, a glucose sensor / includes This enables the measurement and / or estimation of the level of analytes within the host / user via (obtaining). This may include hardware, firmware, and / or software. For example, The analyte sensor electronic module 12 supplies power to the potentiostat and the analyte sensor 10. Power supply for supplying signals, other components useful for signal processing and data storage, and sensors Remote measurement module for transmitting data from an electronic module to one or more display devices. It may contain joules. The electronic device is a printed circuit board in the analyte sensor system 8. It can be fixed to a board (PCB) or platform, and can take on a variety of forms. This is possible. For example, electronic devices include integrated circuits such as application-specific integrated circuits (ASICs). Taking the form of an IC, microcontroller, processor, and / or state machine. It is possible.

[0077] The sensor electronic module 12 processes and converts sensor information such as sensor data. A sensor electronic device configured to generate sensor data and displayable sensor information. This may include placement. Examples of systems and methods for processing sensor analytes are described in this specification. This document and U.S. Patent Nos. 7,310,544 and 6,931,327 and U.S. Patent Nos. 6,931,327 Publication No. 2005 / 0043598, No. 2007 / 0032706, No. 2007 / 0016381, 2008 / 0033254, 2005 / 0203360 No. 2005 / 0154271, No. 2005 / 0192557, No. 2006 Issues / 0222566, 2007 / 0203966, and 2007 / 0208 This is described in more detail in issue 245, and all of these are referenced in this book. It will be included in the specifications.

[0078] Referring further to Figure 1, display devices 110, 120, 130, and / or 14 0 displays displayable sensor information that can be transmitted by the sensor electronic module 12 ( It can be configured (for example, based on their respective preferences) to call and / or warn A customized data package is sent to the display device. Display device 1 Each of 10, 120, 130, or 140 is (each) sensor information and / or A touchscreen that displays analyte data to the user and / or receives input from the user. Includes clean displays such as 112, 122, 132, / or 142 displays. It is possible to do this. For example, a graphical user interface (GUI) can be like this. It may be presented to the user for a specific purpose. In this embodiment, the display device is a display device A touchscreen that transmits sensor information to the user and / or receives user input. Instead of a clean display, or in addition to it, a voice user interface This may include any other type of user interface. In this embodiment, display device 11 One, some, or all of 0, 120, 130, or 140 is the sensor information. When communication is received from the sensor electronic module 12 (for example, when transmitted to each display device) (In the data package provided), additional data required for sensor data calibration and real-time display. To display or otherwise transmit sensor information without any future processing. It can be constructed.

[0079] The multiple display devices 110, 120, 130, and 140 shown in Figure 1 are sensor electronic devices. Analytes received from Joule 12 (for example, numerical values ​​and / or arrows in the embodiment) Designed specifically to display a particular type of visible sensor information associated with the data. This may include a custom-measured display device, such as an analyte display device 110. Embodiment In this, one of the multiple display devices 110, 120, 130, 140 is And Based on Android, iOS, or other operating systems, continuous sensor data ( For example, to display a graphical representation (including current and / or historical data) This includes smartphones such as the configured mobile phone 120.

[0080] As further shown in Figure 1 and described above, system 100 is also an analyte sensor system 8. Multiple display devices 110, 120, 130, 140, etc., server system 134, and wireless A that can be used to connect one or more of the medical devices 136 to each other Access Point (WAP) 138 may be included. For example, WAP 138 is system 100 It may provide WiFi and / or cellular or other wireless connectivity within the system. 100 devices exchange data using Near Field Communication (NFC), Performing specialized functions, such as waking up or powering on a device. Alternatively, exit the lower power mode or change the state in another way, and / Alternatively, the device (e.g., analyte sensor electronic module 12) can switch to an operating mode. This can be done by the and / or transmitter. Using the server system 134, the analyte sensor Collect analyte data from System 8 and / or multiple display devices, for example, minute Perform analysis and generate universal or individualized models of glucose levels and profiles. Services or applications that include individuals or systems remotely monitoring analyte data. We can provide feedback. Overview and examples include partner devices (single or (plural) 136 is a partner device (singular or plural) 136 and / or analyte. In the case of certification of the 8th ANSA system, as well as analyte data, drug data, other data, and / or including replacements such as control signaling, the analyte sensor system 8 and normally Communication can be conducted over a line. In exemplary embodiments of this disclosure, the partner device 136 is It may include passive devices. An example of a partner device 136 is the analyte sensor system 8. In response to and / or in accordance with the user's analyte level measured / approximated using the system. It could be an insulin pump for administering insulin. For various reasons, such The insulin pump receives glucose values ​​transmitted from the analyte sensor system 8 and Tracking may be desirable in some cases (see, for example, Figure 1). One reason for this is... This involves interrupting / activating insulin administration based on whether glucose levels fall below / exceed a threshold. The goal is to provide the insulin pump with the functionality to control it.

[0081] Referring to Figure 2, System 200 is depicted. System 200 is, for example The disclosed systems, methods, apparatus, and / or, including the embodiments described above in relation to Figure 1. This can be used in relation to the implementation of the device embodiment. For example, various examples shown in Figure 2 below Using the mounted components, for example, an analyte sensor system 308, a display device 310, partner device 315, and / or one or more server systems 334, etc. It may be possible to provide wireless communication of analyte (e.g., glucose) data between / between devices.

[0082] As shown in Figure 2, system 200 includes one or more analyte sensor systems 308. This may include a display device 310 and / or one or more partner devices 315. In addition, in the embodiment shown, the system 200 includes a server system 334, The server system 334 is a server system coupled with a processor 334c and a storage device 334b. It may include part 334a. The analyte sensor system 308 communicates via the communication medium 305 and display device 310, partner device 315, and / or server system 334 It can be coupled to the analyte sensor system 308, partner device 315, and / or This involves data processing, collection, exchange, and / or actions by the display device 310, etc. Some details of the implementation (e.g., providing medication or related instructions) are provided below. It can be done.

[0083] Analyte sensor system 308, display device 310, and / or partner device 315 exchanges messages (e.g., control signaling) via the communication medium 305. It may also be done, and the display device 310, partner device 315, and / or service A communication medium 305 may be used to distribute the analysis data to the system 334. As suggested above, the display device 310 is, for example, a smartphone or tablet. , a variety of electronic computing devices such as laptops and wearable devices The display device 310 may also display analyte data and related notifications. It may include an analyte display device 110 that can be customized for transmission. The Vice 315 is a medical device such as insulin pumps or pens, a smart refrigerator, or This may include connectable devices such as mirrors, key fobs, and other devices.

[0084] In this embodiment, the communication medium 305 is, for example, Bluetooth®, Blu etooth(registered trademark) Low Energy (BLE), ZigBee(registered trademark) ), WiFi, IEEE 802.11 protocol, infrared (IR), radio frequency (RF) , 2G, 3G, 4G, 5G, etc., and / or one of the wired protocols and media This can be obtained based on the above wireless communication protocol. Also, considering this disclosure, how many communication media are there? In that case, is such a link explicitly illustrated in Figure 2, or is it related to that? Whether or not they are mentioned in relation to each other, the distinction between the components of System 200 It will be understood that this can be implemented as one or more communication links, including the link. Example As an example, the analyte sensor system 308 uses BLE to communicate with the first RI of the communication medium 305. The display device 310 may be connected via a link, whereas the display device 310 is , using a cellular communication protocol (e.g., 4G LTE / 5G, etc.) as the communication medium 305 The server system 334 may be connected by a second link. In this embodiment, BL The E signal may be temporarily attenuated to minimize data interception. For example, hard Attenuation of BLE signals due to the design of the wearer or firmware can affect data exchange (e.g., BLE This may be done temporarily during a short period of time (such as during an in-person session).

[0085] In the embodiment, the elements of system 200 are used to operate the various processes described herein. It is possible to do and / or relating to one or more disclosed systems and / or methods This disclosure allows for the execution of various operations and / or features described herein. Upon consideration, those skilled in the art will see that system 200 is a single or multiple analyte sensor system 308 It is understood that this may include a communication medium 305 and / or a server system 334. Ro.

[0086] As described above, the communication medium 305 is used to connect the analyte sensor system 308 and the display device. The S310, partner device 315, and / or server system 334 are also connected to each other. It can be connected to or connected to a network in a communicative manner. The communication medium 305 can be implemented in various forms. It can be equipped with a local area network (LAN), for example, a communication medium 305. Wide Area Network (PAN), Wide Area Network (WAN), Fiber Optic Network, powerline internet, hardwired connections (e.g., bus), DSL Internet, etc., or any other type of network connection or communication coupling. It may include one or more of the connections. The communication medium 305 is a router, cable, modem, switch Switches, optical fibers, wires, wireless (e.g., microwave / RF, AM, FM links, etc.) It can be implemented using any combination of such as. Furthermore, the communication medium 305 is Blue tooth(registered trademark), BLE, Wi-Fi, IEEE802.11, 3GPP(registered trademark) Trademarks) Standards (e.g., 2G GSM / GPRS / EDGE, 3G UMTS / CDMA2) 000, or 4G LTE / LTE-A / LTE-U, 5G, or subsequent generations) It can be implemented using various wireless standards. Reading this disclosure, those skilled in the art will recognize other ways to implement the communication medium 305, and also recognize that the communication medium 305 can implement the features of this disclosure using future and undeveloped communication standards. Referring further to FIG. 2, server 334a can receive, collect, and / or monitor information from analyte sensor system 308, partner device 315, and / or display device 310, including analyte data, drug data, and related information, such as an input responsive to analyte data or drug data, or an analyte monitoring application executed on analyte sensor system 308 or display device 310, or an input received in relation to a drug delivery application executed on display device 310 or partner device 315. Thus, server 334a can receive, collect, and / or monitor information from partner device 315, such as information regarding the provision of drugs to a user and / or information regarding the operation of one or more partner devices 315. Server 334a can also receive, collect, and / or monitor information regarding the users of analyte sensor system 308, display device 310, and / or partner device 315. In an embodiment, server 334a can be adapted to receive such information via communication medium 305. This information may be stored in storage device 334b and may be processed by processor 334c. For example, processor 334c can execute an analysis engine that can analyze the information collected, received, etc. by server 334a via communication medium 305.

[0087] Referring further to FIG. 2, server 334a can receive, collect, and / or monitor information from analyte sensor system 308, partner device 315, and / or display device 310, including analyte data, drug data, and related information, such as an input responsive to analyte data or drug data, or an analyte monitoring application executed on analyte sensor system 308 or display device 310, or an input received in relation to a drug delivery application executed on display device 310 or partner device 315. Referring further to FIG. 2, server 334a can receive, collect, and / or monitor information from analyte sensor system 308, partner device 315, and / or display device 310, including analyte data, drug data, and related information, such as an input responsive to analyte data or drug data, or an analyte monitoring application executed on analyte sensor system 308 or display device 310, or an input received in relation to a drug delivery application executed on display device 310 or partner device 315. Referring further to FIG. 2, server 334a can receive, collect, and / or monitor information from analyte sensor system 308, partner device 315, and / or display device 310, including analyte data, drug data, and related information, such as an input responsive to analyte data or drug data, or an analyte monitoring application executed on analyte sensor system 308 or display device 310, or an input received in relation to a drug delivery application executed on display device 310 or partner device 315. [[ID=​​​​​​​​​​​​​​​​​​​​​​​​​​It may include. In an embodiment, the server 334a, the storage device 334b, and / or The processor 334c can be implemented as a distributed computing network such as a Hadoop (registered trademark) network, or as a relational database, etc. Next, the aforementioned information can be processed by the server 334a so as to be provided to the service to the analyte sensor system 308, the display device 310 , the partner device 315, and / or its user(s). For example, such a service may include diabetes management feedback provided to the user. For example, such a service may include diabetes management feedback provided to the user. It may include diabetes management feedback provided to the user.

[0089] In an embodiment, a database may be implemented in the server system 334, and the communication medium 3 05 can be used to pair a user account with one or more analyte sensor systems 308. For example, based on the individual components of the analyte sensor system 308 or one or more groups of components, or the expected lifespan of the analyte sensor system 308 as a whole, and / or based on the diagnostic feedback received by the analyte sensor system 308, the server system 334 can determine whether a given analyte sensor system 308 or its components or a group of components (singular or plural) has reached or passed its useful life. The user can, for example, on the display device 310 and / or via the analyte sensor system 308, from the server system 334, whether its analyte sensor system 308 or components or a group of components (singular or plural) has reached or passed its useful life, or will soon or within a given time whether it has reached or passed its useful life, or will soon or within a given time whether it has reached or passed its useful life, or will soon or within a given time from the server system 334, whether its analyte sensor system 308 or components or a group of components (singular or plural) has reached or passed its useful life, or will soon or within a given time has reached or passed its useful life, or will soon or within a given time The user may receive a display, notification, alert, or warning of a groaning sound. In this embodiment, the user This refers to the analyte sensor system 308 or its components or the group of components. Display, notification, alert, or warning about the expected lifespan of a link(s). This can be received from the server system 334 on the display device 310.

[0090] Server 334a is, for example, an internet server, router, desktop or rack Includes top computers, smartphones, tablets, processors, modules, etc. However, it can be implemented in various forms, including, for example, the following: an integrated circuit or an integrated circuit Assembly, printed circuit board or assembly of printed circuit boards, or individual housing / It may be implemented in various forms, including packages / racks, or a combination of both. In this embodiment, the server 334a performs at least the communication that takes place via the communication medium 305. To partially instruct. Such communication includes analyte data, drug data, and / or it Messaging related to these (e.g., advertisements, authentication, commands, or others) This may include the delivery of messaging. For example, server 334a may have a frequency band, transmission Analysis related to timing, security / encryption, alarms, alerts, notifications, etc. Sensor system 308, display device 310, and / or partner device 315 Messages may be processed and exchanged between and / or between them. Server 334a , analyte sensor system 308, partner device 315, and / or display device The information stored in 310 can be used, for example, to distribute applications to them, or By updating the application and / or system parameters or analysis Object sensor system 308, partner device 315, and / or display device 310 This can be updated by reconfiguring the system parameters or other settings of Server 3. 34a analyzes the analyte in real time, periodically, sporadically, or on an event-driven basis. Sensor system 308, partner device 315, and / or display device 310 Information can be sent and received between them. Furthermore, server 334a can send and receive information between the analyte sensor system 308. Cloud computing for partner device 315 and / or display device 310 A tracking function can be implemented.

[0091] As described above, aspects of the systems and methods of this disclosure for wireless communication of analyte data Herein, we provide examples of some specific features of this disclosure. Those skilled in the art will consider this disclosure. And these features, regardless of whether an explicit reference to these features was made, This can be implemented using the exemplary configurations and / or combinations thereof described above. They will understand.

[0092] Analytical data Referring again to Figure 1, as mentioned above, in the embodiment, within the host or user An analyte sensor system 8 is provided for the measurement of the analyte. Overview and examples of analysis The object sensor system 8 performs sensor measurements and generates analyte data (for example, continuous glucose (By calculating the values ​​of the monitoring data, such data can be used on remote devices (e.g.) For example, display devices 110, 120, 130, 140, partner device 136, and / or a server system 134) for wireless communication (e.g., Bluetooth (registered trademark) and / or other wireless protocols), and can be implemented as an encapsulated micro controller.

[0093] The analyte sensor system 8 may include an analyte sensor 10 configured to measure the concentration or level of an analyte within a host, and an analyte sensor electronic module 12 that is normally physically connected to the analyte sensor 10 before the analyte sensor 10 is implanted in a user. In an implementation form, the analyte sensor electronic module 12 includes, for example, an electronic device configured to process a data stream associated with the analyte concentration measured by the analyte sensor 10 to generate sensor information including raw sensor data, converted sensor data, and / or other sensor data. The analyte sensor electronic module 12 may be further configured to generate sensor information customized for each display device 110, 120, 130, 140, partner device 136, and / or server system 134. The analyte sensor electronic module 12 may be further configured such that different devices can receive different sensor information, and may be further configured to wirelessly transmit the sensor information to such display devices 110, 120, 130, 140, partner device 136, and / or server system 134. As used herein, the term "analyte" is a broad term and is given its ordinary customary meaning to those skilled in the art (limited to a special meaning or customized meaning), and is further configured to receive different sensor information, and may be further configured to wirelessly transmit the sensor information to such display devices 110, 120, 130, 140, partner device 136, and / or server system 134. The term "analyte" as used herein is a broad term and is given its ordinary

[0094] customary meaning to those skilled in the art (limited to a special meaning or customized meaning), and is not limited to a special meaning or customized meaning, (Not fixed), body fluids that can be analyzed (e.g., blood, interstitial fluid, cerebrospinal fluid, lymph) Further refers to, but is not limited to, substances or chemical components in a liquid (or urine). Analyte Examples include naturally occurring substances, artificial substances, metabolites, and / or reaction products. This is possible. In some embodiments, measurement by sensor heads, devices, and methods is possible. The analyte used is glucose. However, acarboxyprothrombin Acylcarnitine, adenine phosphoribosyltransferase, adenosine deaminate -se, albumin, alpha-fetoprotein, amino acid profile (arginine (kleb) (S cycle), histidine / urocanic acid, homocysteine, phenylalanine / tyrosine, Tryptophan, andrenostenidone, antipyrine, arabinitol enantio M, arginase, benzoylecgonin (cocaine), biotinidase, biopter C-reactive protein, carnitine, carnosinase, CD4, ceruloplasmin, Nodeoxycholic acid, chloroquine, cholesterol, cholinesterase, conjugated 1-β-Hydrogen Droxycholic acid, cortisol, creatine kinase, creatine kinase MM iso Zyme, Cyclosporine A, d-Penicillamine, De-ethylchloroquine, Dehydroepi Androsterone sulfate, DNA (acetylation polymorphism, alcohol dehydrogenase, α1 - Antitrypsin, cystic fibrosis, Duchenne / Becker muscular dystrophy, glucoc -6-phosphate dehydrogenase, hemoglobin A, hemoglobin S, hemoglobin C Hemoglobin D, hemoglobin E, hemoglobin F, D Punjab, β-thalassemia, Hepatitis B virus, HCMV, HIV-1, HTLV-1, Leber's hereditary optic neuropathy, M (CAD, RNA, PKU, Plasmodium vivax, sexual differentiation, 21-deoxycortisol) Desbutylhalophanthrin, dihydropteridine reductase, diphtheria / tetanus antivegetation Ingredients, red blood cell arginase, red blood cell protoporphyrin, esterase D, fatty acids / acyl Glycine, free β-human chorionic gonadotropin, free erythrocyte porphyrin, free thyroxine (FT4), free triiodothyronine (FT3), fumarylacetase, galamine Cactose / gal-1-phosphate, galactose-1-phosphate uridyltransferate Ze, gentamicin, glucose-6-phosphate dehydrogenase, glutathione, gluta Thiomyne perioxidase, glycocholic acid, glycosylated hemoglobin, halophanto n, hemoglobin variant, hexosaminidase A, human erythrocyte carbonic anhydrase I, 17-α - Hydroxyprogesterone, hypoxanthine phosphoribosyltransferase, immune Reactive trypsin, lactate, lead, lipoprotein ((a), B / A-1, β), lysozyme Mefloquine, Netylmycin, Phenobarbiton, Phenytoin, Phytanic acid / Prin Stanic acid, progesterone, prolactin, prolidase, purine nucleoside phosphoryl Lase, kinin, inverted triiodothyronine (rT3), selenium, serum pancreatic lipase, cy Somycin, somatomedin C, specific antibodies (adenovirus, antinuclear antibody, anti-zeta antibody, Arbovirus, Aujeszky's disease virus, dengue fever virus, Guinea worm, Tapeworm, Red Entamoeba histolytica, enterovirus, Giardia duodenali sa), Helicobacter pylori, Hepatitis B virus, Herpesvirus, HIV-1, I gE (atopic diseases), influenza virus, Donovan leishmania, leptospermum Pyramid, measles / mumps / rubella, leprosy bacilli, mycoplasma pneumoniae, myoglobin, circumcision Filamentous parasites, parainfluenza virus, Plasmodium falciparum malariae, poliovirus, Pseudomonas aeruginosa, Respiratory rash virus, rickettsia (scrub typhus), schistosomiasis mansoni, toxoplasmosis Protozoa, Treponema pallidium, syphilis treponema, Cruz / Lan Gertrypanosoma, vesicular stomatitis virus Irus), Bancroft's filarial parasite, yellow fever virus), specific antigen (hepatitis B virus, HIV-1), succinylacetone, sulfadoxine, theophylline, tyrotropin ( TSH), thyroxine (T4), thyroxine-binding globulin, trace elements, transfer UDP-galactose-4-epimerase, urea, uroporphyrinogen I-synthesis Other analytes, including -ase, vitamin A, leukocytes, and zinc protoporphyrin, have also been conceived. However, it is not limited to these. Salts, sugars, and proteins that occur naturally in the blood or interstitial fluid. Fats, vitamins, and hormones also constitute the analyte in certain embodiments. To obtain, analytes, such as metabolites, hormones, antigens, and antibodies, are naturally present in body fluids. To obtain. Alternatively, analytes, such as contrast agents for diagnostic imaging, radioisotopes, and chemicals, may be used. A drug, a fluorocarbon-based artificial blood, or a drug or pharmaceutical composition may be introduced into the body. Insulin, glucagon, ethanol, cannabis (marijuana, tetrahydrocannabinol) Hashish), inhalant (nitrous oxide, amyl nitrite, butyl nitrite, chlorohydrocarbons, carbon Hydrogen), cocaine (crack cocaine), stimulants (amphetamine, methamphetamine, Ritalin, Cylert, Preludin, Didrex, PreState, Voranil, Sandrex, Plegine), inhibitors (barbiturates, meta) Charon, tranquilizers, for example, Valium, Librium, Miltown, Ser (ax, Equanil, Tranxene), hallucinogens (phencyclidine, lysergic acid) (Mescaline, peyote, psilocybin), narcotics (heroin, codeine, morphine, aphex) Meperidine, Percocet, Percodan, Tussionex, Fent anyl, Darvon, Talwin, Lomotil), designer drugs (fe Ntanyl, meperidine, amphetamine, methamphetamine, and phencyclidine Examples of analogues include Ecstasy, anabolic steroids, and nicotine. However, this is not limited to these. Metabolites of drugs and pharmaceutical compositions may also be used as analytes. This leads to the idea of: for example, ascorbic acid, uric acid, dopamine, norepinephrine, 3-methyl Toxythiramine (3MT), 3,4-dihydroxyphenylacetic acid (DOPAC), homoba Diphosphate (HVA), 5-hydroxytryptamine (5HT), and 5-hydroxy Neurochemicals and other chemicals produced in the body, such as lendolacetic acid (FHIAA) Any analyte can also be analyzed.

[0095] Pre-connected analyte sensor system As suggested above with reference to Figure 1, in the embodiment, the analyte sensor 10 is, for example If continuous glucose sensors are used, such as subcutaneous, transdermal (e.g., transdermal), or intravascular devices, Includes. In embodiments, such a sensor or device takes multiple intermittent blood samples. It can analyze the following: The analyte sensor 10 can analyze, for example, enzymes, chemicals, physical substances, electrochemistry, Glucose measurement including spectral photonometry, polarization, heat, iontophoresis, radiation, immunochemistry, etc. Any method of precipitation measurement can be used.

[0096] In an embodiment where the analyte sensor 10 is a glucose sensor, the analyte sensor 10 is invasive. Any method including sexual, minimally invasive, and non-invasive detection techniques (e.g., fluorescence monitoring) This can be used to provide a data stream showing glucose concentration within the host. The data stream is typically a raw data signal, and is transmitted to the patient or caregiver (e.g., parent, relative). (Parents, teachers, doctors, nurses, or any other person concerned about the host's health) Calibration and / or other functions that can be used to provide useful glucose values ​​to users. Alternatively, it can be converted into a filtered data stream.

[0097] A glucose sensor is any device that can measure the concentration of glucose. Obtain. According to one exemplary embodiment described below, an embedded glucose sensor is used. It is possible. However, the devices and methods described herein are for analytes, such as glucose. The system detects the concentration and outputs an output signal representing the concentration of the analyte, and similarly the concentration of glucose (e.g., analyte data). It is understood that it can be applied to any device that can provide (in the form of) I want to be understood.

[0098] In this embodiment, the analyte sensor 10 is subject to U.S. Patent No. 6,001,067 and U.S. See Patent Publication US2005 / 0027463-A1 for details on embedded This is a plug-in glucose sensor. In one embodiment, the analyte sensor 10 is a U.S. Patent Publication No. See US2006 / 0020187-A1 for details on transdermal glucans. It is a coarse sensor. In this embodiment, the analyte sensor 10 is U.S. Patent Publication No. US20 U.S. Patent No. 07 / 0027385-A1, filed on October 4, 2006, concurrently pending. Publication No. US2008 / 0119703-A1, filed on March 26, 2007. National Patent Publication No. US2008 / 0108942-A1, and published on February 14, 2007. As stated in the submitted U.S. Patent Application No. US2007 / 0197890-A1 It is configured to be implanted in a host blood vessel or outside the body. In the embodiment, continuous glucose For example, the Scenator is described in U.S. Patent No. 6,565,509 for Say, etc. This includes transdermal sensors such as Bonneca. In this embodiment, the sensor 10 is, for example, Bonneca U.S. Patent No. 6,579,690 for ze, etc., or U.S. Patent No. 6 for Say, etc. Continuous glucose, including subcutaneous sensors as described in publications 484,046. It is a sensor. In the embodiment, the continuous glucose sensor is, for example, Colvin, etc. See U.S. Patent No. 6,512,939 for a refillable Includes subcutaneous sensors. Continuous glucose sensors include, for example, those developed by Schulman et al. in the United States. This may include intravascular sensors, such as those described in Japanese Patent No. 6,477,395. The continuous glucose sensor is, for example, based on U.S. Law 6 for Mastrototaro, etc. This may include intravascular sensors, as described in reference to publications 424 and 847.

[0099] Before system operation, the analyte sensor electronic module 12 typically conserves battery capacity or To manage it, it is maintained in a lower power mode. The analyte sensor electronic module 12 Generally, to start acquiring analyte data in an active power state, it is reliably operated. It should be done. For example, analysis should be performed up to the time before and after the time when the analyte sensor 10 is embedded in the host. It may be preferable not to activate the object sensor electronic module 12. This is because it is more accurate. It can help maintain accurate sensor calibration and reduce power consumption, and It can generally increase the accuracy of analytes, etc. In the implementation configuration, the analyte sensor electronic module 12 and / or the analyte sensor electronic module The operation of the specific circuit of L12 may be performed at least primarily before the implantation of the analyte sensor 10. (For example, 5 minutes, 1 minute, 30 seconds, 10 seconds, 1 second, or less than 1 second before embedding). In some embodiments, the operation of the analyte sensor electronic module 12 is at least primarily embedded During insertion or substantial embedding (for example, when the analyte sensor 10 moves to the deployed position) This can be done (at least partially) while the analyte is being detected. In some embodiments, the analyte sensor electrons The operation of module 12 occurs at least after the implantation of the analyte sensor 10 (for example, 1 second). This can be done at intervals of less than 1 second, 5 seconds, 30 seconds, 1 minute, 3 minutes, 5 minutes, 10 minutes, more than 10 minutes, etc. In this embodiment, the analyte sensor electronic module 12 is installed before the analyte sensor 10 is embedded. It is preferable to terminate the lower power state at a later time or immediately before. This could potentially allow for more accurate recording of the implantation time.

[0100] In systems that are not pre-connected, the analyte sensor 10 and the analyte sensor electronic module 12 is typically the first mechanical and electrical process after the analyte sensor 10 has been implanted in the user. It is connected to the already embedded analyte sensor electronic module 12. When coupled, the electrodes of the analyte sensor electronic module 12 are normally related to the analyte. It is monitored to detect the signal. Then the analyte sensor system 8 detects the user's It can be operated in response to the binding and detection of specific levels or properties of the precipitate. However, In the pre-connected analyte sensor system 8, the analyte sensor system 8 sends to the user Before this, the analyte sensor 10 is electromechanically coupled to the analyte sensor electronic module 12. Therefore, when the sensor is embedded, the analyte sensor electronic module 12 is the analyte sensor It is already joined to 10. As suggested above, this pre-join or pre-connection is For example (e.g., in conditions of high humidity, static electricity, electrical leakage, or noise), before embedding the sensor... The signal generated by the precipitate sensor system 8 may cause a false wake-up or more This could lead to operation from low power states. Furthermore, using a sensor processing algorithm... To improve the accuracy when converting the sensor signal, the analyte sensor 10 is used before implantation. In cases where it is preferable that the analyte sensor electronic module 12 is not voltage-biased, be.

[0101] Actions that may cause changes in the characteristics of the analyte sensor 10 are generally minimized before implantation. It should be kept to a minimum. Therefore, before embedding, the voltage bias analyzer sensor 10 It may be preferable to avoid or at least reduce the occurrence. (For a relatively long period of time) For example, by applying a voltage bias to the analyte sensor 10 (during storage), the analyte sensor The service life of SA10 may be shorter than the intended service life following implantation. For example, due to the consumption of a reference volume or enzyme volume that may be contained on the analyte sensor 10. It is possible. Furthermore, the analyte processing algorithm that can be used by the analyte sensor system 8 The sm may depend on the characterized performance values ​​of the analyte sensor 10. These characterized The performance metrics included baseline signal, analyte sensitivity, signal drift, and lot performance metrics. The curve fitting variables, tabular values, calibration codes, and / or analyte values ​​are determined. Additional factors that can be used as part of a signal processing algorithm in relation to determining these factors include This is possible. Therefore, in some cases, especially the analyte sensor 10 calibrated at the factory In this case, to enable accurate generation of analyte values, the analyte sensor is implanted in the user. It may be important to make relatively accurate estimates of the 10 performance parameters and / or characteristics. A voltage bias is applied across both ends of the analyte sensor 10 for a significant period (e.g., shelf life). During this period, deviations from one or more given performance metrics may occur. This is an analysis. After embedding the material sensor 10, one or more measured analyte sensor 10 signals are converted to analyte values. The accuracy of the analyte values ​​determined using the sensor processing algorithm for conversion is reduced. There is a tendency for this to occur. Furthermore, deviations from the calibrated state of the analyte sensor 10 during storage may occur. Potential for causing algorithms to report less accurate or inaccurate analyte values. There is.

[0102] Furthermore, the circuit and / or other components that control the operation of the analyte sensor system 8 The amount of power used by the sensor (for example, within the analyte sensor electronic module) (for example, mW) is generally related to making system-level performance tradeoffs where possible. It should be minimized, reduced, and / or considered. Analytical Sensor 1 For measurements generated using 0 or other circuits or components, generally, minutes Before operating the precipitate sensor system 8, minimize and reduce power consumption, and / or It should be arranged to control it. The power budget is for the analyte sensor system. The battery capacity of 8 can be limited, at least to some extent. Therefore, the analyte sensor System 8 may remain at a lower power or almost non-operating state before activation, and the system The technology used to control operation and / or terminate lower power states is It can consume only a small portion of the available power.

[0103] In one embodiment, lower power consumption is achieved, for example, during system startup events and / or This reduces or minimizes the viable power consumption and detectability of triggers. This is achieved by selecting a ring or sampling frequency. In some cases This is a sampling or polling method used to monitor operational events / triggers / characteristics. The ringing frequency depends on the type of detection method used (for example, electrostatic, as described below). It may vary based on capacity measurement versus accelerometer input. In relation to reducing power consumption, the main system Measurement to trigger system wake-up without powering on the processor. And lower-power state machines may be used to perform logic functions. For example, reduced Variable and / or variable, adaptable, programmable, and / or configurable By using polling or sampling frequency, lower power states can be effectively detected. It can be maintained. In some cases, this can be achieved by using low-power state machines. The power state can be easily determined. The operation event of the analyte sensor system 8 can be detected. Despite periodic polling / sampling that may be performed in connection with this, power consumption Lower power levels that allow for cost control / reduction are generally maintained in this manner. can.

[0104] In this embodiment, the analyte sensor system 8 is more robust against false wake-ups. If an incorrect wake-up is detected, the system will return to a lower power state. This is possible. For example, at any given time, the analyte sensor system 8 will wake up if a wake-up event occurs. The analyzer sensor 10 generates a signal that does not meet the threshold or one or more characteristics. If this is detected, the analyzer sensor system 8 will return to a lower power state or a lower power state. The power state may remain unchanged. For example, in such a lower power state, the analyzer sensor power There may be cases where data transmission or analyte measurement by sub-module 12 is absent. In many cases, Lower power states and active states can be implemented primarily in firmware, however Some wake-up circuits (for example, as described herein) discharge capacitors It may have hardware integration to enable a more robust operation detection mechanism (such as an electric one). .

[0105] Therefore, embodiments of the present disclosure are lower than the pre-connected analyte sensor system 8. Numerous techniques and / or mechanisms for detecting and confirming that the power state may change. This involves the use of components / circuits. For example, such changes can affect the analysis of analytes. System 8 is activated and terminates the lower power state, and / or This may be accompanied by being moved to an active state. This means that the analyte sensor 10 is used by the user This can occur in response to conditions indicating that it is embedded in an analyte sensor system. 8 applies a voltage bias to the analyte sensor 10 and one or more electrodes of the analyte sensor 10. a potentiostat or other measuring device that measures the amount resulting from the flow of current The analyte can be detected using a vise and / or related currents. The signal may be referred to as the primary signal in this specification.

[0106] In addition, for example, measurements can be taken when the analyte sensor 10 is implanted in the host tissue. There may be characteristic signal profiles. Such characteristic signal profiles are, for example, Changes resulting from membrane hydration and / or analyte and / or ion concentrations From the changes in the analyte sensor 10 when it is first exposed to the tissue environment, This can result in a characteristic signal profile, which in this specification is referred to as a secondary signal. It could be detected. In the embodiment, the secondary signal is the capacitance, impedance of the analyte sensor 10. This may include, or may involve, the use of other electrical measurements.

[0107] The analyte sensor 10, along with its in vivo and / or factory calibration information (for example) For example, the signal characteristics of a primary signal measured using voltage or current are, for example, the primary signal To convert the number to the analyte concentration level, the analyte sensor electronic module 12 is used for implementation. It can be used by the analyte processing algorithm. The signal characteristics of the first-order signal are as follows over time. It may change. Analyte value (for example, can be measured in mg / dL), or analyte sensor 1 Other measurements performed using one or more electrodes of 0 (e.g., voltage, current, digital "cow") Examples of signal profiles (such as "signal") include the following: signal gradient, signal threshold, and time-dependent Other special features that may be used to specifically identify integrals, slopes, balances, ranges, or signals. One example is the signal profile / characteristics of the analyte sensor system 8. It can be defined as follows.

[0108] In the pre-connected analyte sensor system 8, numerous technologies mentioned above and By using other means such as operation / state changes, the analyte sensor 10 can be embedded in the user. It can detect congestion more accurately, which in turn has many advantages. For example, minutes By accurately detecting or estimating the embedding time of the precipitate sensor 10, it is calibrated at the factory. This could be made possible by a better system. For example, (see Figure 5 as an example) The signal processing algorithm implemented using the processor 535 of the analyte sensor system 308 Zoom uses one or more techniques in converting analyte sensor signals into estimated analyte values. This is possible. Various periods in the lifecycle of the analyte sensor 10 (for example, within 1 hour after implantation) During periods such as 4 hours after embedding, 4 hours or more after embedding, these conversion technologies will not change. It may provide different levels of precision regarding the exchange system. In the embodiment, among these techniques Some of these may depend on a given signal profile that is time-dependent. Therefore, Recording and / or estimating the more accurate embedding time of the precipitate sensor 10 is important for signal processing. The selection of a logical algorithm and the handling of variations in processing techniques that can be performed as a function of time. This may be beneficial. Therefore, using such techniques / means in analytes is beneficial. The system 8 offers improved overall accuracy, as well as improved implantation of the analyte sensor 10. It may have the ability to accurately evaluate / detect the time the analyte sensor 10 is embedded (for example, it may have the ability to accurately evaluate / detect the time the analyte sensor 10 is embedded). The performance during embedding is affected, including by errors that may be induced by its absence. (This may be due to the following factors) For example, the gradient of the sensitivity of the analyte sensor 10 after implantation or background signal changes that may occur following the implantation of the analyte sensor 10. Therefore, inaccuracies can be introduced.

[0109] Accurate detection of the embedding time is also important in terms of providing analyte information to the user. This can enable faster starting of the 8th generation system. For example, more precise embedding. The time is determined by the analyte calculation algorithm implemented in the analyte sensor system 8, which uses analyte information. Determining the appropriate point in time to begin displaying information to the user (for example, the confidence level between the signal and the analyte transformation). This may be useful for the first period after the implantation of the analyte sensor 10 (e.g., 2 hours). The embedded timing error is due to the slope of the signal change related to the analyte within the signal response. This can lead to inaccurate predictions regarding the analyte signal. The timing of the characteristic signal decay curve By recognizing, the analyte sensor system 8 and / or the analyte sensor system 8 The linked device failed to accurately determine the implantation time of the analyte sensor 10. It can be done relatively quickly (for example, 2 hours, 1 hour, 30 minutes, 15 minutes, or shorter) than the previous method. Within a certain time, the analyte information can be displayed or provided (for example, Figure 1 as an example). Refer to the server system 134 on display devices 110, 120, 130, and 140. , and / or to partner device(s) 136).

[0110] In addition, accurate detection of the embedding time of the analyte sensor 10 is necessary for the reuse of the analyte sensor 10. This can help prevent the following: Sensor embedding time by electronic module 12 Detection relies more on users providing notifications for insertion / embedding times. This can enable reliability metrics such as disconnection and / or embedding. The function is to replace the newly inserted analyte sensor 10 with the expired analyte sensor 10. This can be distinguished from attempts to initiate it.

[0111] As an additional example, the accurate detection / estimation of the embedding time of the analyte sensor 10 is performed by the analyte sensor Between the analyte sensor module 12 and the device connectable to the analyte sensor module 12 This may enable faster connection establishment (see, for example, Figure 1). Embedding of the analyte sensor 10 With more accurate detection and / or estimation of time, the analyte sensor system 8 is almost buried Multiple devices are established based on the time of insertion or implantation, and a large number of devices It can be put into a state where it communicates with the vice. For example, the analyzer sensor system 8 is a display device (For example, refer to Figure 1 as an example, display devices 110, 120, 130, 140, A toner device (one or more) 136, etc., connects wirelessly to the analyte sensor system 8. To make this possible, the embedding time is relatively short (e.g., less than 10-15 minutes). It may be possible to transition to the pairing state during this time. Also, the analyte sensor 10 Using more accurate detection of embedded time, trigger alternative connection profiles and pairing It can facilitate faster connections through features such as slash, encryption, and advertisement characteristics. That is, for example, using a more definitive wake-up event, the analyte sensor system More proactive connection modes, such as between M8 and devices that can be connected to the analyte sensor system 8. Dell can be made easier (for example, advertising packets at a faster speed) (Such as transmitting). This can enable faster connection establishment, and also for analyte sensor systems. 8 is receiving a signal and is connected to a display device, which is in near real-time. Feedback can be provided to users.

[0112] More robust wake-up technology for analyte sensor 8 may enable analytes An additional example of the benefits associated with accurately estimating the embedding time of sensor 10 is error detection. This improves the ability to know the predicted profile and analyze the analyte from the time of implantation. By monitoring the signal measured using SA10, the embedding in the signal profile can be performed. It is possible to recognize deviations from the expected characteristics of the sample. This is possible with the analyzer sensor 10. Knowledge of implantation time, as well as the ability to analyze the analyte signal at the time of implantation (e.g., implantation The associated signal is not visible because the analyte sensor system 8 is in a lower power state. This can be made possible by (a low probability of being missed). The ability to recognize such deviations is This could be dangerous for the user of the precipitate sensor system 8, potentially affecting the safety or accuracy of the system. This could trigger an error. For example, physical damage (e.g., membrane breakage, (Damage, manufacturing errors, etc.) The analyte sensor 10 may have different characteristic signals after implantation. .

[0113] Another example of the advantages associated with accurately estimating the implantation time of the analyte sensor 10 is This results in a faster wake-up time for the analyte sensor system 8, which also enables error detection. This may enable improved output capacity. User variation during the embedding time of the analyte sensor 10. The ske uses a pre-connected analyte sensor system 8, and the analyte This can be reduced by automatically or semi-automatically detecting the embedding time of the sensor 10. This can result in the wrong tissue location (for example, muscle / muscle instead of subcutaneous tissue or in a tissue layer other than the desired one). The analyte sensor 10 inserted into the membrane exhibited characteristics different from those expected after insertion. It may have a signal. A faster wake-up time follows after embedding such problems. This enables faster detection and is associated with the overall analysis sensor system 8. Error detection performance may improve.

[0114] Figure 3A shows a pre-connected analyte sensor system 8 and its associated components in several embodiments. A perspective view of a skin sensor assembly 360 that can be used as a skin analyte is shown. The sensor assembly 360 may include an analyte sensor system 8, as shown in Figure 1, for example. The skin sensor assembly 360 comprises a first upper portion 392 and a second lower portion 394. It may include an outer housing. In the embodiment, the outer housing has a clamshell design. It may include. The skin sensor assembly 360 is the analyte sensor electron mentioned above in relation to Figure 1. Components similar to those in Module 140, such as potentiostats and analyte sensors. Power supply, signal processing components, and data storage components for supplying power to unit 10. , and communication modules for one-way or two-way data communication (e.g., telemetry module) (Lure), printed circuit board (PCB), integrated circuit (IC), application-specific integrated circuit (ASI) C) may include a microcontroller and / or processor.

[0115] As shown in Figure 3A, the outer housing may generally be characterized by an elliptical shape. The side housing is positioned substantially through the central portion of the outer housing, and sensor 3 38 and the bottom of the skin sensor assembly 360 are fitted with an opening for needle insertion. The part 396 may further include. In this embodiment, the opening 396 is a channel or a long slot It may be. The skin sensor assembly 360 is a skin sensor assembly 360. The embodiment may further include an adhesive patch 326 configured to be fixed to the skin of the person. Adhesive patch 326 is an adhesive suitable for skin adhesion, for example, for attaching to the skin. Carrier base material (e.g., spunlace polyester, polyurethane film, or other preferred material) A pressure-sensitive adhesive (e.g., acrylic, rubber, or other suitable type) bonded to a suitable type of adhesive. This may include (type), but any suitable type of adhesive can also be conceived. As illustrated. The adhesive patch 396 adheres to the bottom of the sensor assembly 360 on the skin, so that the sensor 338 adheres to the bottom of the sensor assembly 360. The system features an opening 398 that is aligned with the opening 396 so that the ch 396 can pass through. obtain.

[0116] Figure 3B shows a bottom perspective view of the skin sensor assembly 360 of Figure 3A. Qualitatively, the opening 396 is located in the central part of the bottom of the skin sensor assembly 360, and The mouth portion 398 and the other portion are further shown, both of which are adapted for the sensor 338 and needle insertion.

[0117] Figure 4 shows a cross-sectional view of the skin sensor assembly 360 shown in Figures 3A and 3B. , the first upper portion 392 and the second lower portion 394 of the outer housing, and the adhesive patch 326 And, the opening 396 in the central part of the skin sensor assembly 360 and the adhesive patch 326 The central opening 398 and the sensor 338 passing through the opening 396 are shown. (See Figure 3A) The aforementioned electronic device unit includes a circuit board 404 and at least one power supply to the circuit board 404. It may further include a battery 402 configured to supply power.

[0118] Referring now to Figure 5, we see a more detailed functional block diagram of the analyte sensor system 308. For example, the figures discussed above in relation to Figures 1 and 2 are provided. As illustrated in Figure 5... The analyte sensor system 308 processes and manages sensor data for analytes. The analyte sensor 530 (for example, indicated by reference numeral 10 in Figure 1) is coupled to the sensor measurement circuit 525. (may include) the sensor measurement circuit 525 is a processor / microprocessor 5 35 (which may be part of item 12 in Figure 1, for example) may be coupled. Several embodiments So, the processor 535 acquires and processes sensor measurements from the sensor 530. This may perform some or all of the functions of the sensor measurement circuit 525.

[0119] The processor 535 transmits sensor and other data, and responds to requests and commands. In addition, it receives other signals from external devices such as the display device 310 (see Figure 2 as an example). To communicate, a wireless unit or transceiver 510 (for example, part of item 12 in Figure 1) The display device 310 can be further coupled with sensor data (or analyte data). The data (or data derived therefrom) is shared with the user, server system 334, and / or Alternatively, it may be used to display or otherwise provide information on the partner device 315. The Tona Device 315 administers drugs (e.g., insulin) and / or sugars to the user. In the guidance for managing urinary tract diseases, sensor data or derived data from sensor data The term "wireless unit" and "transceiver" as used in this specification may be used. The term can be used interchangeably and generally refers to the transmission and reception of data wirelessly. This refers to a device that can do the following. The analyte sensor system 308 collects sensor data and other data. A storage device 515 (for example, part of item 12 in Figure 1) for storing and tracking data. (possibly) and Real-time Clock (RTC) 540 (for example, part of item 12 in Figure 1) It may further include (which is possible).

[0120] The analyte sensor system 308 may also include an action detection circuit 520. 20 may optionally operate in conjunction with the motion detection component 545. The analyte sensor system 545 may be integrated into the analyte sensor system 308. It may be a component that can be attached to the Tem308, and / or an analyte sensor. It may be located outside the system 308. An example of the operation detection circuit 520 is (1) capacitance Or, a measurement that measures electrical characteristics associated with the analyzer sensor 10, such as impedance. (2) A constant circuit, for example, can be used, such as capacitive detection, inductive detection, magnetic detection, sound wave detection, etc. (3) Proximity detection circuit, temperature measurement circuit, (4) Accelerometer circuit, (5) NFC / RFID (6) wire and / or antenna circuitry, (7) barometric pressure detection circuitry, (8) audio circuitry, (9) optical detection Circuits, (9) conductivity measurement circuit, (10) switch detection circuit, (11) strain detection circuit, etc. This may include one or more of the following: Actuation detection circuit 520 and / or actuation detection component. 545 also tracks events / conditions and / or measurements of analytical values / characteristics / profiles. Based on this, the system detects operational events / triggers and analyzes the analyte in other ways. Features such as those described herein that enable the operation of the sensor system 8 To execute, it is adapted to execute stored instructions or computer code. The logic circuit may be used or include. Actuation detection circuit 520 and actuation detection component 5 Further details regarding 45 will be discussed elsewhere in this specification.

[0121] An exemplary implementation of the analyte sensor system 308 uses the sensor 530 to analyze the analyte Data is collected and the analyte data or derivatives of the analyte data are displayed on the device 310, part Transmitted to device 315 and / or server system 334. Regarding analyte values. Data points can be collected and transmitted over the lifetime of the sensor 530. New measurements The values ​​and / or related information are obtained by the remote device / individual from the analyte (e.g., glucose). The signal can be transmitted at a frequency sufficient to adequately monitor the level.

[0122] Analyte sensor system 308, partner device 315, and / or display device Many details of processing, collecting, and exchanging data by 310, etc., are described herein. Please understand that this information may be provided elsewhere. Considering this disclosure, the analyte sensor System 308 is shown in at least some embodiments herein, as shown in Figure 1 or Figure 2. It is understood that this may include several similar components described in relation to this. Therefore, for details and usage of such similar components, please refer to Figure 5. Even if not explicitly stated herein, the analyte sensor system 308 may be used in reference to the analyte sensor system 308. It can be understood.

[0123] End of low power state As discussed above, the embodiments of the present disclosure are particularly characterized in that the analyte sensor system 308 is pre- If it is a connected system, activate the analyte sensor system 308 or more This concerns the timing of causing it to exit low power mode. For example, In a pre-connected system like this, the analyte sensor 10 is hosted by the host Before being embedded, it is mechanically and electrically coupled to the analyte sensor electronic module 12. Obtain. The analyte sensor system 308 may exit in several different lower power modes. There are periods, and each period typically has associated trade-offs.

[0124] One period during which the analyte sensor system 308 may end up in a lower power state is when the user When opening the package containing the analyte sensor system 308, or when the user opens this This is when removing the analyte sensor system 308 from such a package. For example, Honmei Using the switches, magnets, or other means described in the manual, the analyte sensor system 308 In response to the opening of the shipping box or sterile pack for the analyte sensor system 308, In response to the removal of the system cap / lid, and / or the system's foil / tie In response to the delamination of the Beck packaging, the system will terminate the lower power state. This can be done. However, by ending the lower power state during this period, the analytes It is highly likely that this is not immediately before the sensor 10 is inserted into the user, and therefore the analyte sensor The power usage requirements of the sensor system 308 will potentially increase. For example, a large number of analyte sensors When Stem 308 is typically supplied to users in a single package (e.g., 4 packs) In total, it is likely that only one of the analyte sensor systems 308 will be used in the near future. Even if there are exceptions, all supplied analyte sensor systems 308 will operate in this scenario. It is possible. In another example, the user removes the packaging lid of the analyte sensor system 308. After removing it, and thus triggering the biasing of the analyte sensor 10, the analyte sensor 1 Until the bias is 0, or until other secondary verification means are used, the analyte sensor 10 It is possible to delay the embedding of such secondary verification means (for example) As described in detail in this specification, NFC, accelerometer, impedance measurement, etc. This wastes power used to perform the function and results from applying a bias. The resulting calibration drift potentially reduces the accuracy of the analyte sensor 10.

[0125] Another exemplary period during which the analyte sensor system 308 may exit a lower power state is minutes. The precipitate sensor system 308 is inside the applicator but has not yet been deployed. . As will be discussed in more detail, mechanical means (e.g., bridges) and electrical or other means This includes non-mechanical means (e.g., NFC, magnetic, sonic detection, etc.). In certain situations, During this period, it may be easier to detect activation events, for example, during this period Possible normally detectable events (when the analyte sensor system 308 interacts with the applicator) (For example, changing the position) is associated with the deployment of the analyte sensor system 308. Because this can occur over a longer period compared to the detectable events that can be obtained, this period This may be preferable. This period is usually closer in time to the embedding of the analyte sensor 10. Therefore, it may be preferable to detect indicators related to operation, and thus For example, a user unpacks the analyte sensor system 308, but then the analyte sensor 10 User-created errors can occur, such as when choosing not to embed something. This helps reduce wake-up. Therefore, the analyte sensor system 308 Possible events in the precator estimate the embedding time and / or analyzer sensor To activate system 308 or to terminate a lower power state, It can act as a more effective marker for detection.

[0126] The analyte sensor system 308 can be made to terminate the lower power state. Another period involves the deployment of the analyte sensor system 308 (for example, into the host tissue). (The analyte sensor 10 is moving from a proximal position to a distal position.) Here too, electrical means Using either or electromechanical means, or both, the analyzer sensor system 308 It can trigger activation. However, if you use deployment-related events for activation purposes, One potential problem is that deployment is usually associated with an applicator, for example (as mentioned above). For indicators related to operation that occur, this is done over a shorter period of time. Therefore, for a signal or an event associated with the applicator, the signal or event is This can be easily overlooked or difficult to detect.

[0127] Used to cause the analyte sensor system 308 to terminate a lower power state. Another possible period is after the implantation of the analyte sensor 10. Analyte sensor system To trigger the operation of 308, mechanical, electrical, and / or electromechanical (or Other non-mechanical means may be used. In addition to or instead of this, an analyte sensor may be used. To trigger system 308 to wake up or exit a lower power state The analyte sensor 10 itself may be used. For example, the measured data of the analyte sensor 10 Measured values ​​of capacitance and / or sensor film impedance, and / or The measured value of the skin impedance of the skin is compared to a known condition (e.g., a threshold). That comparison can be used to demonstrate the embedding of the analyte sensor 10. It is acceptable to do so. However, after inserting the analyte sensor 10, the insertion of the analyte sensor 10 If there is a delay in detecting the analyte, the analyte processing algorithm used to calculate the analyte value will This could affect the accuracy of the smear. Furthermore, such delays can affect the analyte sensor system. The 308 will pair with the display device 310, the partner device 315, etc. The system performs actions such as transmitting analyte values ​​to the display device 310, partner device 315, etc. This could potentially affect the ability to perform other actions that are possible.

[0128] Using signals from the analyzer sensor to terminate lower power states As mentioned above, embodiments of this disclosure use, for example, an analyte sensor 10 to embed Detecting the implantation of the analyte sensor 10 into the user, including when an implantation is detected. And, to operate and / or terminate lower power states in an accurate and power-efficient manner. This involves having the analyte sensor system 308 perform the analysis. In an exemplary embodiment, the analysis The analysis signal from the object sensor 10 is used for the purpose of operation. For example, operation detection circuit 52 0 uses one or more signals from the potentiostat to generate the analyte signal, and or / or, for example, with analyte sensor 10 (or analyte sensor 530, see Figure 5) However, these components may be called interchangeably in some cases. Flow can be detected / measured over time. Such signals include pA (current flow) and pW ( Power, or count (from analog values ​​such as voltage, current, power, and / or time) It may also be quantified in units such as converted digital values, as in the analyte sensor system 308 These values ​​can be used to trigger an event that ends a lower power state. For example, in order to trigger the wake-up or activation of the analyte sensor system 308, A benchmark threshold for the unit of current may be used. However, such a trigger is a given current. Based on a threshold of units (e.g., counts), false wake-ups or wayouts occur. This can lead to missed detections. For example, if the analyte sensor 10 is properly embedded in the host Even if not mixed (for example, while the analyte sensor 10 is being packaged, before deployment) (Due to the electrostatic discharge that may occur) If a predetermined threshold is met, a lower power state Or, in situations where storage mode should be maintained, transitioning to wake-up or operating mode. This may be performed by the analyte sensor system 308.

[0129] Therefore, embodiments of the analyte sensor system 308 generally use units of seconds or minutes. For example, an analyte sensor 10 that can measure over a specific time period (300 seconds or 5 minutes). A benchmark threshold for current measurements (for example, approximately X counts, where X is X) For example, it may use a benchmark (which could be 9000 counts). In a particular embodiment, a benchmark is used. The threshold, which is considered a benchmark, can be monitored in light of persistent conditions, and the benchmark is The threshold is such that it must be reached or exceeded for a predetermined period of time before the action is triggered. It is configured in such a way that the analyte sensor system 308 should be able to wake up reliably. This can help ensure that the current is measured for the purpose of operation. For example, the continuous conditions are used to measure the current. A consistent frequency current measurement across a subset of durations used (for example, several In some cases, this may include digital counting. For example, this can lead to analyte detection. A period for monitoring the current passing through the analyte sensor 10 in order to activate the system 308. Unwanted anomalies such as short-term spikes in internal current (or, for example, digital counts) Based on this, it can be ensured that the benchmark threshold is not reached.

[0130] The measured current of the analyte sensor 10 (e.g., the number of counts received) is measured by the benchmark. It can be compared to a threshold (for example, X counts, which may be approximately 9000 counts). A set current (e.g., the number of counts received) is used to determine the benchmark threshold (e.g., X counts). If it is determined that the threshold has been reached or exceeded, the operation detection cycle will be triggered. Processor 5 is either part of path 520 or can operate in conjunction with operation detection circuit 520. 35 can start the operating mode of the analyte sensor system 308. For example, minutes The analyte sensor system 308 receives / acquires sensor information from the analyte sensor 530. This can be initiated. In some embodiments, for example, the estimated analyte value data is then 1 It is transmitted to one or more display devices 110, etc. That is, the processor 535 activates It remains in its original state and has one or more display devices 110, partner devices 136, etc. For communication purposes, sensor information (e.g., current, digital count) is sent to the transceiver 510. It can transfer / communicate and / or process the measured current (for example). For example, the number of digital counts received (e.g., X counts) is used to determine the benchmark threshold. If it is determined that the analyte sensor does not reach or exceed the benchmark threshold, System 308 may remain in a lower power state and / or storage mode. In some cases, the measured current (e.g., the number of counts received) , whether the benchmark threshold (e.g., a threshold related to counts) has been reached, or benchmark Following the determination that the mark threshold has been exceeded, the measured value (for example, the received count) The number of (e.g., the number of (t)) is used during the second period (V) to determine the second benchmark (e.g., the count threshold ( To determine whether U)) has been reached or whether the second benchmark has been exceeded. This allows for a different determination of whether the abnormality associated with the analyte sensor signal is A more robust system against the resulting false wake-up This could result in a problem.

[0131] Figure 7A shows a schematic of the equivalent circuit model 700 of the analyte sensor 10 according to an embodiment of the present disclosure. The diagram shows that the sensor circuit model 700 is an embodiment of a continuous glucose sensor, and the analyte The electrical characteristics of sensor 10 can be represented. Circuit 700 has a first terminal 704 (for example) (which may be the working electrode) and a second terminal 702 (which may be, for example, the reference electrode) The first terminal 704 and the second terminal are operably connected in series to the second terminal 702. Rsolution 712 represents the resistance of bulk 706 between terminal 702. Bulk 706 is, for example, in bench laboratory studies, or in subcutaneously placed analytes. In the example of use as SA10, a liquid containing an analyte sensor 10, such as a buffer solution. (For example, interstitial fluid) or other media, bulk 706 is connected to the first terminal 704 and the second terminal 704. This can represent the subcutaneous tissue environment between the terminal 702 and the other terminal.

[0132] The membrane 7 of the analyte sensor 10 is operationally connected to Rsolution712. Cmembrane716 representing capacitance 08, and membrane 708 of analyte sensor 10 This is Rmembrane714, representing resistance. It consists of Cdouble layer 718 and Rpolari The parallel network with zation720 is operationally connected to Rmembrane714. The parallel network consists of Cdouble layer 718 and Rpolarization layer 720. The workpiece represents the reaction occurring on the surface of the platinum interface of the first terminal 704. In particular, Cdoubl The e-layer 718 is where the electricity accumulated when the working electrode (e.g., platinum) is in the bulk 706 is located. Rpolarization 720 represents the electrical charge that can occur at the working electrode interface 710. This is the polarization resistance of a chemical reaction.

[0133] In an exemplary embodiment, a non-analyte signal is generated using the analyte sensor 10, and analysis is performed. To activate the object sensor system 308 and / or exit the lower power mode. It is used for the purpose of having the analyte sensor system 308 perform the analysis. The object signal may represent specific electrical, physical, or other characteristics of the analyte sensor 10. It includes signals. For example, the stimulus signal is used to determine a specific characteristic of the analyte sensor 10. It can be used.

[0134] According to one embodiment, the analyte sensor system 308 is triggered to activate a lower power state. And / or to terminate, the capacitance of the analyte sensor 10 may be detected and used. For example, the capacitance of the analyte sensor 10 is such that the film of the analyte sensor 10 is hydrated or This may change when placed in an environment with higher or lower humidity. Operation detection cycle The path 520 responds to the capacitance of the analyte sensor 10 and time through the analyte sensor 10. It drives fluctuating signals (e.g., square waves, voltage steps, AC signals, etc.) and the signal is divided The circuit may include a circuit to detect how the capacitance of the precipitate sensor 10 affects the result. How the analyte sensor 10 responds to the drive signal is related to the analyte sensor 10. It can show the capacitance. For example, to detect the threshold response to a drive signal, analysis A minimum level of capacitance may be required for the material sensor 10. Therefore, the analyte sensor system TEM 308 uses the operation detection circuit 520 to indicate the capacitance of the analyte sensor 10. The ric can be measured, and based on its capacitance metric, the analyte sensor 10 It is possible to determine whether it is embedded in the host. Measured electrostatic capacitance The quantities are (see Figure 7A as an example) Cmembrane 716, Cdouble layer 71 8, and one or more of the other capacitances associated with the analyte sensor 10 may be included. This should be understood. For example, the drive signal is connected to the first terminal 702 and the second terminal 704. The analyte sensor 10 can pass through there, where the drive signal is transmitted to the membrane. 716, Cdouble layer 718, and other electrostatics that may be associated with the analyte sensor 10 The capacitance affects the load of the capacitance and / or analyte sensor 10. It can be used to estimate the total amount of capacitance to be obtained.

[0135] The impedance triggers the analyte sensor system 308 to create a lower power state. Another characteristic of the analyte sensor 10 that can be detected and used to activate and / or terminate Figure 7B shows the impedance value of the analyte sensor 10 (e.g., in units of ohms). An exemplary plot 726 of time (e.g., in seconds) from 22 pairs of embeddings 724 is shown. As shown in the figure, the impedance value 722 of the analyte sensor 10 follows after implantation. It may begin to decrease after a certain period of time (for example, 30 seconds). Furthermore, as shown in the figure, impedance After the initial decay of the dance value 722, the impedance value 722 is embedded in the analyte sensor 10. After a certain period following the initial implantation, the results stabilize. Possible changes that may occur (for example, a decrease in the impedance value of 722, or a change in the impedance value) Factors such as the conversion rate can be used to detect / trigger operation.

[0136] Figure 7C shows another exemplary plot for an impedance value of 730 (e.g., in ohms). Figure 7C illustrates impedance value 730 versus hydration 732 (for example, % The plot provides (in units of) hydration 732 associated with the membrane of the analyte sensor 10. Hydration may occur. Generally, the humidity outside the human body is such that the analyte sensor 10 is inside the human body. This can result in membrane hydration levels that are lower than those normally associated with the membrane. It is possible. Therefore, the moisture in the environment, and the results (of, for example, the membrane of the analyte sensor 10) Using the resulting hydration level, the analyte sensor 10 is implanted in the host's body. It may indicate that it is either embedded or not embedded. In addition, in some cases the analyte Even if sensor 10 is not inserted into the host's body, certain environmental conditions (e.g., humidity) This may trigger the activation of the analyte sensor system 308.

[0137] In addition, the measurable electrical characteristics associated with the analyte sensor 10 include ambient humidity and moisture. Humidity, moisture, and / or hydration can vary as a function of membrane hydration. Such measurable electrical properties as functions (e.g., impedance, capacitance, etc.) ) Variations in some cases result in measurable electrical characteristics of the analyte sensor system 308 To activate it, or to use humidity, hydration, and / or moisture levels directly, for example Rather than doing so, the analyzer sensor system 308 is instructed to terminate the lower power state. It would be good if it could function as a more reliable indicator for that purpose. For example, several In this case, humidity, moisture, and / or membrane hydration are detected when the analyte sensor 10 is inserted into the host. Other reasons (for example, high moisture content in the packaging of the analyte sensor system 308) The bell may increase, and therefore the analyte sensor system 308 may falsely wake up. It can be triggered. Therefore, the humidity / moisture and specific measurable electrical characteristics of the analyte sensor 10 By utilizing the relationship between properties (e.g., impedance, capacitance, etc.), the analyte sensor 1 To more accurately detect insertion events of 0 and to create the analyte sensor system 308 in response to them It can be moved.

[0138] For example, under lower humidity conditions (e.g., 90%RH), the impedance is relatively It can be high (for example, 10 MΩ). However, the analyte sensor 10 is embedded. And, in some cases, the impedance decreases relatively rapidly (for example, to several hundred kΩ). There is a possibility that the change, rate of change, and / or threshold may be reduced. Therefore, in the embodiment, the change, rate of change, and / or threshold Impedance value (for example, a specific but non-limiting example is approximately 300-500k) Using Ω, on the one hand, high humidity conditions that can occur in a non-insertive environment outside the host body, and on the other hand, The moisture conditions that may occur in relation to the implantation of the precipitate sensor 10 in the host's body, It can be distinguished. This is because environmental conditions trigger the analyte sensor system 308. To activate or deactivate a lower power state, when it is undesirable to do so, It can help to stop (or resist). The desired level of the impedance threshold is Wake-up trigger time of analyte sensor system 308 after insertion of analyte sensor 10 The time that can be allocated to the signal can be based on, for example, noise, signal magnitude, and frequency. The robustness of the state against false wake-ups resulting from inaccuracies in road measurements, etc. It may be disabled. An example of a feasible wake-up trigger time is approximately 30 seconds. Examples include, but are not limited to, times of approximately 60 seconds or more.

[0139] As shown in Figure 7C, the hydrated 736 (e.g., before embedding the analyte sensor system 10) For example, in units of %, point 740 on plot 734 has an impedance value of 738 (for example) In addition, in the hydration 756 that follows the embedding of the analyte sensor 10, Point 760 corresponds to impedance value 758. In this embodiment, impedance value 75 8 may be significantly lower than the impedance value 738, and as a result, plot 73 4. The impedance values ​​744 and impedance corresponding to points 746 and 752 on the above, respectively. The impedance value range between 750 and the embedded analyte sensor 10 detects the presence of the sensor. It can be used as a threshold for, and therefore, to trigger the analyte sensor system 308. It can be used to activate and / or terminate lower power states. Additional or other In this example, the gradient or derivative of the impedance value as a function of hydration is monitored, and the analyte is... The embedding of sensor 10 can be detected. Therefore, for example, the analyte sensor 10 It is possible to monitor impedance, and when the impedance crosses the impedance threshold... (For example, achieving threshold differentiation, gradient, or other conditions) the analyte sensor The activation or change in the state of TEM308 can be triggered. In a specific example, the analyte sensor Before insertion of the analyte sensor 10, the host body is subjected to a relatively low hydration level (for example, the host body). (Within the range of values ​​typical for ambient humidity outside or in a specific environment), and associated with it It may have an impedance of 10 MΩ. Next, the analyte sensor 10 is inserted into the user's body. Afterward, as hydration increases, the impedance value of the analyte sensor 10 is approximately 1 It can drop to 00kΩ.

[0140] The impedance associated with the analyte sensor 10 is, for example, a voltage or current step. Using various methods, including using P or other functions, (for example, those The entirety of U.S. Patent No. 9,801,575 is incorporated herein by reference. (As shown) using electrochemical impedance spectroscopy, or any other known method It may be measured using the following: For example, the operation detection circuit 520 of the analyte sensor 10 Step functions or other functions or signals that can be used to measure impedance This may include the operation of driver circuits (e.g., function generators, oscillators, etc.) for generation. Then, a voltage associated with a step function or other signal is applied to the analyte sensor 10. Therefore, the current resulting from the current between the terminals of the analyte sensor 10 is used by the operation detection circuit 520. This can be detected. Next, in an exemplary implementation, the applied voltage and the resulting current The impedance of the analyte sensor 10 can be calculated using the relationship between the two.

[0141] Generally, the goal is to reduce / minimize battery power consumption and use more power than necessary or appropriate. In order to avoid sending a large amount of current to the analyte sensor 10, the operation is performed in a manner that avoids sending a large amount of current to the sensor. Impedance measurements are also possible with relatively low amplitude waveforms (for example, less than approximately 50mV). Alternatively, use a net current of zero (for example, centered around an electrode voltage bias of 0V). In the embodiment, as described above, the measured value indicating impedance is the analyte. By applying a voltage (for example, a step function) to the sensor 10, the operation detection circuit 520 It can be characterized using the resulting current flow (e.g., including current spikes). The size of the visible part may be inversely proportional to the impedance of the membrane of the analyte sensor 10. Using Ohm's law, for example, impedance is the same as voltage and current, although not limited to impedance. This can be determined by monitoring the digital counts, and / or one or both of them. ru.

[0142] The operation detection circuit 520 detects whether the impedance is above or below a set level. It may include a circuit to detect whether it is. For such a circuit, see at least Figure 8A and Figures 12-14 will be discussed in more detail below. Regarding Figure 8A, high level The circuit then provides a voltage source that can apply, for example, a square wave or other waveform to the analyzer sensor 10. Positive current spikes can be captured using a switch that can be driven by the device. Next, a positive current can be used to charge the capacitor. The voltage that can occur across the capacitor... This can represent the measured impedance of the analyte sensor 10 (for example, analyte sensor 10 Measured based on a voltage divider that can be placed between the impedance and a known impedance. (To enable analysis) By using a voltage comparator circuit set to the desired level, analysis can be performed. The insertion of the object sensor 10 is detected, and the analyzer sensor system 308 is triggered to detect lower power levels. To terminate the process, the insertion of the analyte sensor 10 can be used. Such a circuit It can operate at very low power (for example, less than 1uA during lower power states). It may be designed and integrated into a chip. When the embedding of the analyte sensor 10 is detected, The chip and / or circuitry transmits control signals to the processor 535 to enable lower power operation. The analyzer sensor system 308 can be instructed to terminate the operation.

[0143] In this embodiment, a voltage-current amplifier and an additional switch are used to control the analyte sensor. After the TEM308 exits the lower power state, the analyte sensor 10 is disconnected from the detection circuit. Obtained. Under high humidity conditions (for example, those that may occur during storage), the analyte passes through the analyte sensor 10. It should also be noted that the net current may be limited. This is because the analyte sensor 10 is fixed. The analyte sensor system 308 applies a constant bias (for example, a voltage such as 0.6V). This can offer advantages over methods for dynamics. Under high humidity conditions, the current flowing through the analyte sensor 10 as a result of applying a fixed bias is This could consume an undesirable amount of power and / or affect the performance of the analyzer sensor 10. It could have repercussions.

[0144] Now, moving to Figure 8A, an exemplary operation detection circuit 800 according to an embodiment of the present disclosure is shown. Circuit 800 is used, for example, to operate the analyte sensor system 308. It can be used to detect current in a wake-up circuit with lower power. At a high level, referring to Figure 5 as an example and situation of a specific embodiment, circuit 800 This uses the inrush (e.g., charging) current through the capacitance of the analyte sensor 530 to determine the voltage. A pulse can be generated. The voltage pulse can be monitored by a detection circuit, and if the pulse is 1 If more than one of the above conditions is met, the analyte sensor system 308 is triggered, and the lower The power state may be terminated. For example, in certain embodiments, when the voltage threshold is exceeded. A certain number of pulses can trigger the operation of the analyte sensor system 308. Additional examples include: It is listed below.

[0145] Circuit 800 contains one or more switches and one or more current-limiting resistors and other components. Using the embedded event of the analyte sensor 530, which can detect events more accurately, Then, activate the analyte sensor system 308 or exit the lower power mode. This can provide more robust control for the analyte sensor system 308 to perform this task. For example, at the first point in time, the switch is used to connect the first terminal of the analyte sensor 530 to the potentiometer. It can be coupled to an Ostat or other measuring device or other measuring circuit. Detection In certain examples, the circuit may contain amplifying elements (e.g., comparators, low-noise amplifiers, other amplifiers, etc.). It may include and / or other circuits. The detection circuit is, for example, the capacitance of the analyte sensor 530. Based on the current that can flow through (for example, charging), the electricity generated using circuit 800 The system checks whether the pressure exceeds a threshold or whether one or more other conditions are met. It can be used to output. The voltage exceeds the conditions (singular or plural), or it If any other conditions (one or more) are met, the analyte sensor system 308 will be activated. This can trigger the following: For example, such a voltage can trigger capacitor 834, switch element Child 818 and / or driver circuit 806, etc., included in circuit 800 or circuit It can be generated using the current-voltage conversion action of the component that can be used by the 800. .

[0146] Then, for example, at the second point in time, the first terminal of the analyte sensor 530 is connected to the measuring device (e.g. For example, a switch that can be used to connect to a potentiostat is open, or The first terminal of the analyte sensor 530 is set to a high impedance state and connected to the measuring device / potentiometer. While the osiostat can be disconnected, the second switch is, for example, a current limiting resistor. The first terminal and the second terminal of the analyte sensor 530 are connected to each other via the device, and the analyte The capacitance of sensor 530 can be discharged at least substantially. The potential that may exist between both ends of the analyte sensor 530 is set, reset, and / or zeroed. This allows for a complete reset of the circuit, thus effectively resetting the analyte sensor 5. The inrush event of the charging current through the 30 capacitances is repeated, and therefore another detectable This enables more robust operation detection mechanisms for the analyte sensor system 308. This may become possible. In some cases, this operation detection mechanism is used by the analyte sensor 5 With respect to 30, it is possible to more reliably distinguish between a number of electrical characteristics that can be measured, and several Such electrical characteristics may indicate the hydration state of the analyte sensor 530, and other such characteristics This simply indicates a high humidity environment, and allows the analyte sensor system 308 to be more appropriate and reliable. Or it can be made to work precisely.

[0147] More specifically, Figure 8A shows that circuit 800 connects to the analyte sensor 808 and measuring device 81 The diagram illustrates that it may include 0 (for example, a potentiostat). Furthermore, the analyte sensor 808 is, for example, the analyte sensor 530, which is referenced in relation to Figure 5. It may be similar, substantially similar, or identical to what is described herein, as a person skilled in the art studying this disclosure would know. Therefore, it will be understood. In a particular embodiment, the analyte sensor 808 is an analyte sensor Depending on the circumstances and / or applications in which the 530 and / or 808 may be used, analysis The object sensor 530 may differ at least partially from the measuring device 810, which is an analyte sensor. To apply a bias to 808 and / or to the embedded analyte sensor 808 Analyte sensor 808 can be used to calculate the level of analytes in a sample. It can be used to collect information from.

[0148] In addition, the circuit 800 may include a capacitive element 834, and optionally a resistive element 832. Includes. Circuit 800 may also include detection circuit 802, and detection circuit 802 may include several In this case, for example, an amplifying element (e.g., a comparator) may be used or included. In addition, the circuit 800 is a reference voltage 804, a reference voltage 818, and, for example, a clock-based driver It may include one or more of the driver circuits 806 which may be a reference voltage 804 Please understand that one or more of the 818s can substitute for other reference signals. It should also be understood that path 806 can be driven by signals other than the clock signal.

[0149] In this embodiment, a current-based operating method for the analyte sensor system 308 is shown in Figure 8A. This can be carried out using a circuit similar to the circuit 800 shown in the figure. However, some In relation to such embodiments, certain modifications can be made. For example, the switch element Child 812 may not be present in circuit 800, or it may be bypassed or short-circuited, for example. It may also be the case that the switch element 814 is not present or the circuit 800 is They may be effectively removed and / or in a high impedance state or open circuit state It may be placed there. In such a case, the resistor 832 is also effectively removed from the circuit 800. Other means may be used to effectively remove and / or bypass the resistor element 832. It should be understood that it may be used. In the embodiment, the embedding of the analyte sensor 808 is , a specific (for example,) between the first terminal 828 and the second terminal 830 of the analyte sensor 808. Still determining / monitoring based on detecting sufficient current flow (one or more). It is possible.

[0150] Herein, exemplary features of such a modification or similar version of circuit 800 are as follows: The measuring device 810 is provided as such. The terminals 828 and 83 of the analyte sensor 830 A potential (e.g., a substantially continuous voltage) can be applied between zeros. For example, terminal 82 8 is the current flow through the analyte sensor 808 to the terminal 824 of the measuring device 810 (for example) In some cases, it can be supplied via a potentiostat, terminal 830 It can also be placed in a higher potential. In addition, for example, terminal 826 of measuring device 810 The terminal 830 of the analyte sensor 808 is connected to each other and / or to the current-voltage conversion circuit. They can be combined.

[0151] In this embodiment, the current-voltage conversion circuit is coupled to terminals 826 and 830 at the first end. a capacitive element 83 which can be coupled to a reference voltage 818 (e.g., ground) at its second end. It may include 4. The first end of the capacitive element may also be coupled to the switching element 816. The switching element 816 may be driven by the drive circuit 806, and the drive circuit 806 is It may include and / or use clock-based or other signal type drivers. The switching element 816 thus connects terminals 826 and 830 to the reference voltage 818. They can be coupled and uncoupled alternately. Terminals 826 and 830 are configurable and programmable. According to a flexible, adaptable, and / or variable interval / frequency (e.g., 10Hz), It can be periodically coupled to and disconnected from the reference voltage 818. In some cases, the driver circuit 806 aperiodically couples / disconnects terminals 826 and 830 to / from the reference voltage 818. It can be asynchronous and / or event-driven.

[0152] For example, the switching element 816, for instance, at a first time point, has a higher impedance state When placed in a certain position or opened, terminals 826 and 830 are switched off from the reference voltage 818. They can be separated or detached (for example, they can be floating). The current flowing through the capacitance of the analyzer sensor 808 is used as a charging current to power the capacitive element 834. This can be effectively supplied. This charging current can generate a potential across the capacitive element 834. The switching element 816, for example, at a second time point, has a lower impedance or conductivity state. When placed or closed, terminals 826 and 830 are, in some cases, It can be directly connected to or coupled to the reference voltage 818 (e.g., ground). In this configuration, Any charge that may be stored in the quantitative element 834 is discharged, at least substantially (for example, to ground). Therefore, the potential that can occur across the capacitive element 834 is at least the reference voltage 81 It can be returned / reset to near a potential of 8 (e.g., ground or 0V). Therefore, in this example, the current is switched on the analyzer sensor 808 by the action of the switch element 816. When capacitance flows, the resulting voltage signal may be present at terminals 826 and 830. The waveform is a series of voltage pulses (for example, the voltage between the ends of the capacitive element 834 as a function of time). This can represent pressure, and such pulses represent the magnitude of the current passing through the capacitance of the analyte sensor 808. It can be proportional to.

[0153] Continuing with this example, in circuit 800, the input 822 of the detection circuit 802 (for example, an amplifying element) A voltage detection circuit (which can be implemented as a comparator, other circuits, etc.) is located at terminals 826 and 830. It can be coupled to. In this embodiment, the detection circuit 802 detects the voltage across the capacitive element 834. Compared to a reference voltage 804, which may be configurable, programmable, variable, adaptable, etc. It is capable of operating in this manner. The detection circuit 802 is activated when certain conditions (one or more) are met. If (for example, if the voltage across the capacitive element 834 exceeds the range of the reference voltage 804) If it is, is below, or is within a range, or exhibits a specific trend, (In combination), it produces an output 836 which can be used, for example, to trigger the operation of the analyte sensor 308. It may be further operable to achieve this. The reference voltage 804 may be configured based on calibration. , can be set according to a predetermined value / characteristic, and / or depending on the situation or current It should be noted that the field analyzer sensor system 308 may be configured based on the environmental conditions it experiences. Furthermore, the detection circuit 802 can satisfy the threshold (for example, can reach the threshold). Count several sequential voltage pulses (which may exceed a threshold) and / or otherwise specify A configurable digital logic circuit (not shown in Figure 8A) capable of operating to mark or measure. This includes and / or may include: for example, the number of pulses measured / monitored and / or If the characteristics satisfy the configurable conditions (e.g., number / size of thresholds), output 836 is The analyte sensor system 308 operates to terminate the lower power state, or This indicates that it should cause or trigger to terminate. obtain.

[0154] However, in certain cases, the above example is a specific electrical model of the analyte sensor 808. It may be particularly suitable for use in conjunction with the analyte sample. For example, the example circuit described above is suitable for use with the analyte sample. Sensor 808 substantially or purely resists between terminals 828 and 830 of analyte sensor 808. This may be more suitable for implementations modeled as resistance loads. However, in certain cases, The substantially resistive load may not be an approximate representation of the analyte sensor 808. In the case of a substantially or purely resistive load, the capacitive element 8 is affected as a result of the charging current. The voltage pulses that may occur across both ends of 34 are substantially constant for a given substantially constant current. The amplitude can be constant. Therefore, the amplitude of the voltage pulse can increase in proportion to the increase in current. ru.

[0155] However, as described above in relation to Figure 7A, in this embodiment, the analyte sensor 808 The electrical behavior of is not accurately modeled by a substantially or purely resistive load. There is also the option of including both a capacitor and a resistor, as shown in Figure 7A, for example. Furthermore, using a more complex passive circuit model that may include other elements, the analyte sensor 808 It may be more accurate to model it electrically. For example, the relative of the analyte sensor 808 If a large capacitance Cdouble layer 718 is included in the possible electrical models, When terminals 828 and 830 of the analyte sensor 808 are first connected to the circuit 800, Route 800 can operate in different ways. In some cases, the difference is significant, or It may be recognizable. For example, when a resistance model / load is used, the result is Instead of a constant amplitude voltage pulse sequence or column (for example, related to the above example) As described, the waveform characteristics of the voltage across the capacitive element 834 are as shown in the analyzer sensor 808. The capacitance is substantially affected by the initial inrush of the charging current that can flow through it (and several (In that case it may be dominated) This has a larger amplitude initially, followed by This can result in (e.g., a series of) voltage pulses with decreasing amplitude. The amplitude is several In this case, it can decrease rapidly, for example, the analyte sensor 808 shown in Figure 7A as an example. According to the exponential decay that can be associated with the resistance / capacitance (RC) characteristics of the electrical equivalent model It can be reduced significantly. Here, we refer to Figure 8B as an example, which will be discussed further below. This will be discussed in detail. As shown in Figure 8B, for example, pulses that may be included in waveform 870 The value exhibits exponential decay over a period of 845. However, the resistive model is used for the analyte sensor. When used with the 808, this attenuation may not exist, and instead, the waveform of the 870 It is important to understand that pulses can have a relatively constant amplitude.

[0156] Furthermore, the capacitance of the analyte sensor 808 is charged, and the current flow mainly becomes the steady-state current. If this is the case, the operation of the current-voltage circuit is significantly affected by the presence of a charged capacitor. It may remain affected in some way. For example, when a more complex electrical model is used, Residual voltage pulses that can be measured across the capacitive element 834 for a given steady-state current The amplitude of the signal is equivalent to the steady-state current of the analyte sensor 808 under the resistive load electrical model. It may be significantly lower than the current. Furthermore, the corresponding voltage waves for two different currents. The proportional difference in size of the shape is no longer sufficiently distinguishable by the detection circuit 802 under normal circumstances. There is a possibility that it may not work. For example, the detection circuit 802 is used when the electrical model in Figure 7A is used. The resulting relatively small or reduced difference in steady-state voltage pulse amplitude Therefore, it may not always be possible to accurately detect threshold crossovers and other similar issues.

[0157] Therefore, taking the above into consideration, the exemplary configuration of the circuit 800 described above is the detection circuit 802 This may result in a voltage pulse waveform that is not large enough for detection or distinction. It should be understood that this steady-state current can be generated in circuit 800. The exemplary configuration may not facilitate the accurate and robust operation of the analyte sensor system 308. Yes. For example, sufficient that can be detected more easily / accurately / reliably by the detection circuit 802. There may be only one or a few opportunities to generate a voltage waveform. For example, charging current. The initial relatively large voltage pulse that may result from the initial inrush is a single detection event It may only provide a signal. Also, this initial relatively large pulse or multiple pulses may be detected. If not detected by circuit 802, or as a result of the initial pulse(s) (one or more) If the analyte sensor system 308 does not operate (for example, when connecting to circuit 800), (Because the substance sensor 808 may not be sufficiently hydrated), circuit 800 is used to analyze the substance sensor 8 There may not be another sufficiently detectable opportunity to detect / evaluate the embedding of 08. ru.

[0158] Therefore, embodiments of the present disclosure relate to circuit components such as switches and other elements. This includes the configuration of a circuit 800 that can be reset by [some means]. See, for example, Figure 8A further. The circuit 800 may include switch elements 812 and 814. Switch element 812, 814 and 816 are transistors or other passive / active devices (e.g., FETs). Electrical components including discrete or integrated components such as switches. It can be implemented using a component. As will be discussed in more detail below, the switch component Sub-elements 812 and 814 can be opened when one switch element is closed, and vice versa. Similarly, they can be complementary. Switch elements 812 and 814 are clock Alternatively, it may be controlled using other signal drivers, and in some cases, this clock is The clock or other source / drive signal used in the driver circuit 806 can be derived. In the embodiment, the switch elements 812 and 814 may be used in the driver circuit 806. A clock or other source with a lower frequency than the clock or other source It can be controlled by, for example, the (e.g., clock) frequency of switch elements 812 and 814. The number can be a fraction of the (e.g., clock) frequency of the switching element 816, and is used The resulting fractional value may be configurable, programmable, adaptable, and / or variable. As examples / options of fractions, in some cases 1 / 10, 1 / 20, 1 / 40, 1 / 80 is one example. Therefore, for each of these examples / options, the switch element 812 And 814 controls the clock of the switch element 816 by 10, 20, 40, or 80 cycles. The state can be changed with each step. Driver circuit 806 and switch elements 812 and 814 Other ratios and relationships that can be set with respect to control can be understood by considering this disclosure. It will be understood.

[0159] The output 836 of the detection circuit 802 is, for example, the processor 5 of the analyte sensor system 308. Since it can be coupled to 35, output 836 activates or triggers the analyte sensor system 308. It can be used for [unclear / unclear]. Circuit 800 is implemented within or in conjunction with the operation detection circuit 520. It is possible that circuit 800 is used as an operation detection circuit 520, or as part of the operation detection circuit 520. If implemented as such, output 836 can be coupled to processor 535, so do so. When the signal is transmitted in this way, the processor 535 will tell the analyzer sensor system 308 how This causes it to quench or terminate a lower power state. It can be used to trigger as described above, analyte sensor 808 This may include a first terminal 828 and a second terminal 830. The detection circuit 802 is a reference terminal It may include terminals 820 and input terminal 822. The measuring device 810 has a first terminal 824 and It may include a second terminal 826.

[0160] As stated, the circuit 800 can be used to control the operation of the analyte sensor system 308. The detection circuit 802 checks whether the signal at input terminal 822 meets one or more conditions. It can indicate whether or not. For example, the condition is the reference terminal (one or more) 82 of the detection circuit 802. One or more thresholds that can be set using a reference voltage (one or more) applied to 0 804 The value may be a voltage, or may include one or more threshold voltages. Input terminal (single or The voltage (singular or plural) of 822 is transmitted between the first terminal 828 and the second terminal of the analyte sensor 808. The circuit of the circuit 800 including terminal 830 (for example, the capacitive element 834 as described above) (Using an element, the current passing through the analyzer sensor 808 can be effectively converted into a voltage.) It can indicate the current that can be generated. For example, the conditions (single or multiple) are programmable, adaptable. A threshold that is variable and / or configurable, and this threshold is used and / or This threshold may be included.

[0161] In a specific example, the condition (singular or plural) is one or more signals provided at input terminal 822. The voltage (singular or plural) of the number is when the analyte sensor 808 is embedded in the host. Or under other conditions, between the first terminal 828 and the second terminal 830 of the analyte sensor 808 It can be configured such that the conditions (one or more) can be met when indicating the current that can flow through it. In such cases, the output (single or multiple) 836 of the detection circuit 802 is connected to the input terminal 82. This signal (single or multiple) in 2 is (for example, output signal (single or multiple) 836 (Depending on the level, singular or plural) Indicates that the conditions (singular or plural) are met. This triggers the analyzer sensor system 308 to terminate the lower power state. It can be used for the following purposes. For example, in some cases the output of detection circuit 802 (singular) (or multiple) 836 is one or more trigger states or active states of the analyte sensor system 308. Binary levels, multiple discrete levels, which can be used to trigger operation to a live state. and / or may include continuous or substantially continuous values ​​or analog values. In this case, the state into which the analyte sensor system 308 transitions is the characteristic of output 836 (for example, This may depend on factors such as the bell, trend, etc. In the embodiment, this will be further discussed in relation to Figure 8B. The condition (single or multiple) is that a certain number of voltage pulses satisfy the threshold (single or multiple). When a threshold is reached or exceeded (for example, when a certain number of voltage pulses are used), or when a certain number of voltage pulses are used When the set exceeds a threshold (one or more), the condition (one or more) is met. It can be composed of the following.

[0162] The switch element 812 connects the first terminal 828 of the analyte sensor 808 to the measuring device 810. To connect to / from the first terminal 824 (for example, a potentiostat) It can be used. The switch element 814 detects the first terminal 828 of the analyte sensor 808. Connected to / from input terminal 822 of path 802 (optionally via resistor 832) or disconnected. It can be used for the following purposes. The input terminal 822 of the detection circuit 802 is the first of the analyte sensor 808. The two terminals 830 can be coupled to the second terminal 826 of the measuring device 810.

[0163] At the first point in time, the switch element 812 is either closed or in a conductive state. The first terminal 828 of the analyte sensor 808 is connected to the first terminal 824 of the measuring device 810. It can be coupled. The switch element 814 is open at this point, or high impedance It is in a state where the input terminal 822 of the detection circuit 802 is connected to the first analyte sensor 808. It can be separated from terminal 828. Therefore, at the first point in time, the measuring device 810 is the host Used in connection with collecting information that can be used to calculate the level of the analyte within. It is possible. Furthermore, using circuit 800 (for example, as mentioned above), especially the analytes The voltage waveform generated using the charging current that can flow through the capacitance of sensor 808 is transmitted to terminal 82 Power is supplied to 2 and the detection circuit 802 (e.g., an amplifying element and / or a comparator or other circuit) It is monitored and compared to the reference voltage 804 using (which may or may include) It is possible.

[0164] At the second point in time, the switch element 812 is either open or in a high impedance state. It is configured and therefore the first terminal 828 of the analyte sensor 808 is connected to the measuring device 8 It can be separated from the first terminal 824 of 10. The switch element 814 is closed at this point. It is set to a low impedance or conductive state, and therefore the analyte The second terminal 830 of the sensor 808 can be coupled to the first terminal 828 of the analyte sensor 808. (In some cases, optionally, via the resistive element 832). This is the analyte sensor 80 Reduce or, in some cases eliminate the potential present between the ends of 8, and the driver 806 and S Using the switching action of the switch element 816, the analyte sensor 808 (for example, Figure 7A) Discharge at least substantially the stored charge of the capacitance (see reference) to conduct to the reference voltage 818. A path can be created. As stated, the resistor element 832 is the switch element 814 and / or This is when 816 is closed or in a conductive or low impedance state. Optionally used to limit the current that may flow through the switch elements 814 and / or 816. It can be used.

[0165] The capacitive element 834 is connected to the input terminal 822 of the detection circuit 802 (in this example, the analyte sensor 8 (Illustrated as being coupled to the second terminal 830 of 08) and voltage reference 818 (e.g.) For example, it can be coupled between (ground). The switch element 816 is connected to the driver circuit 806 or Driven by signals (e.g., a clock or other signals) or otherwise connected to inputs Since it can be obtained by using the input terminal 822 of the detection circuit 802 as a reference, the switch element 816 It can be periodically coupled to 818. For example, if the reference voltage 818 is ground, this is: As will be further mentioned / discussed in relation to Figure 8B, the capacitive element 834 is at least substantially It can discharge into the driver circuit 806 and / or It can be used in conjunction with the switch element 816 to implement a current-voltage circuit. The current that can flow through the analyte sensor 808 is determined, as mentioned above, when the threshold / condition is met. In relation to determining whether a threshold / condition is met, or changing the state, Further related to activating and / or triggering the analyte sensor system 308 Then, using the detection circuit 802, the voltage can be measured or otherwise characterized. For example, it may be possible to operate in a way that converts it to a waveform.

[0166] In the embodiment, switch elements 812 and 814 are configured such that switch element 812 or switch It can be driven by a common signal that can be inverted for either of the 814 elements. Alternatively, the switch elements 812 and 814 may be driven by a common signal, The devices used in switches 812 and 814 may have opposite polarity. For example, In the embodiment, switch elements 812 and 814 are Driven to be configured to be in the opposite (e.g., impedance) state at a given time. It is possible. Therefore, the switch elements 812 and 814 are, for the most part, switches. When element 812 is closed, switch element 814 opens, and vice versa. It can be configured in this way. When configured in this way, the switch elements 812 and 814 Use to discharge at least substantially the capacitance associated with the analyte sensor 808. Therefore, it is possible to implant the analyte sensor 808 into the host's body and is usually associated with The initial inrush current passing through the capacitance of the attachable analyte sensor 808 is roughly regenerated and used The analyzer sensor system 308 is then activated to terminate the lower power state. To generate additional voltage pulses that can be monitored for the purpose of causing and / or having it do so This is possible. Therefore, the current lag resulting from the embedding of the analyte sensor 808 In situations where the shuff does not trigger the operation, switch elements 812 and 814 are used to activate circuit 8 Because 00 can be effectively reset, another monitorable current rush occurs, This may trigger the operation of the analyte sensor system 308.

[0167] In addition to this, / instead of this, to enable flexibility, adjustment, configuration, and / or optimization. The timing for controlling switch elements 812 and 814 to be in different states is: Switch elements 812 and / or 814 can be used for various durations / intervals / frequencyes / etc. So that it can be placed in a specific state / mode according to a call / or duty cycle, It is predetermined, programmable, adaptable, variable, and / or configured. This is possible. Such timing control can be implemented using the driver circuit 806. , and / or can be derived from driver circuit 806, for example, driver circuit 80 For every given number of cycles of 6, the states of switch elements 812 and 814 change, and / Alternatively, it may be maintained for a selectable / controllable duration.

[0168] Figure 8B shows the signals of the analyte sensor 808 according to an embodiment of the present disclosure (e.g., voltage, current, etc.). An exemplary plot of ( ) is shown. Waveforms 870 and 880 represent signals (e.g., voltage, current). (For example) 840 can be expressed as a function of time 842 (for example, in seconds), and such a signal is, (See Figure 8A as an example) Located on the input terminal 822 of the detection circuit 802 within the circuit 800. The reference voltage 848 is the same as above. As shown above, the voltage or other signal present on the input terminal 822 of the detection circuit 802 is the reference voltage. If it reaches 848, exceeds the reference voltage of 848, or crosses the reference voltage of 848, the detection The output 836 of the output circuit 802 is used to trigger the operation of the analyte sensor system 308. It can be set so that this is possible. As shown in Figure 8B, the end of waveform 870 and the wave During the time between the start and end of the 880, the signal on the input terminal 822 of the detection circuit 802 (for example) If the voltage is applied, in particular, it closes switch element 814 and / or switch element 816. This may result in at least a substantial discharge or reset. By resetting the voltage across the sensor 808, circuit 800 is activated on input terminal 822. The voltage may cross the reference voltage 848, reach the reference voltage 848, or the reference voltage 848 It may become possible to monitor additional detection events that could exceed 8.

[0169] As shown in Figure 8B, waveform 870 is pulses 844a, 844b, and 844 c may include additional pulses (including pulses not explicitly shown) as illustrated. This may include: a non-limiting example, the driver circuit 806, a switch element 816 A clock (e.g., square wave, sine wave, etc.) or other signal can be provided to drive it. The period of the clock signal is the interval between each of the pulses 844a, 844b, and 844c. It is possible. In a specific example, the driver circuit 806 controls the operation of the switch element 816. It can provide aperiodic, asynchronous, and / or event-driven signals for this purpose.

[0170] As a non-limiting example, waveform 870 is a specific waveform that can be approximately 1 second in some cases. The duration may be 845, and the duration of the clock signal from the driver circuit 806 is approximately This could be 100 milliseconds. Furthermore, as shown, the embedding of the analyte sensor 808 into the host The initial current rush of waveform 870 that may result from the insertion and correspond to (for example) After the voltage pulse 844a, each subsequent pulse 844b, 844c, etc., is analyzed, for example. The effective time constant of the object sensor 808 (for example, the RC time constant as described above) can be associated with it. The amplitude may decrease according to the attenuation profile. Therefore, as mentioned above, the switch Elements 812 and 814 are used to create pulses of a specific size (for example, pulse 84 The initial current rush used to form 4a) can be largely regenerated. This is, for example, , illustrated by waveform 880 which may include pulses 846a, 846b, 846c, etc. ru.

[0171] When switch elements 812 and 814 are set in the manner described above, the waveform 870 is, As shown in the interval 855, it can drop to ground or another reference voltage or close to it. In the embodiment, the period 855 is approximately 1 second (for example, the static period of the analyzer sensor 808). Any duration sufficient and / or long enough to substantially and / or completely discharge the electrical capacity (At other times) it may be, and then waveform 880 and pulse 846a switch element 812 And it can be measured according to the state of 814. Next, the analyte sensor system 308 is activated. To that end, waveform 880 can be monitored in the manner described above.

[0172] 1 which can be used to operate the analyte sensor system 308 in relation to circuit 800 With respect to the above conditions, many variations can be conceived in connection with this disclosure. For example, pulse 84 A single pulse such as 4a has reached the threshold 848, has exceeded the threshold 848, and / or if it intersects with threshold 848 or otherwise satisfies the condition, This can trigger the operation of the precipitate sensor system 308. In this embodiment, a predefined number of Russ 844a, 844b, 844c have reached the threshold 848, or have exceeded the threshold 848. If the condition is met, and / or if it crosses the threshold 848, or otherwise satisfies the condition Being present can trigger the operation. In some cases, a certain number of two or more waveforms can trigger the operation. The pulses (e.g., waveforms 870, 880, etc.), or about each waveform 870, 880 Each of the different numbers of pulses (e.g., 844a, 844b, etc., and 846a, 84) 6b, etc.) can be used to trigger an action. In a specific example, to achieve the condition, If the number of pulses from waveform 870 does not result in operation, then one from waveform 880 The above pulses can be monitored for operational purposes. In some cases, the threshold 848 is set to a specific threshold. A specific number of pulses exceeding a certain quantity can trigger the operation of the analyte sensor system 308. In this embodiment, the first condition is achieved in relation to a detection circuit that measures pulses of waveform 870. If not, a second (e.g., modified) condition monitors the pulse of waveform 880. It can be used for that purpose.

[0173] In this embodiment, the analyte sensor system 308 responds to the waveform 870 with lower power When activated and / or triggered to terminate a state, in certain cases waveform 880 It is not necessary for the following to be generated. In other cases, two or more waveforms 870 are used for the purpose of operation. Waveforms such as 880 may be used, and subsequent waveforms other than waveforms 870 and 880 (as shown in Figure 8B) (Not present) may not need to be generated. In some cases, the analyte sensor 308 If it does not activate in response to at least one of the waveforms 870, 880, etc., additional Waveforms can be continuously generated. In the embodiment, the analyte sensor system 308 is not activated. After a number of configurable waveforms are generated, in some cases a predetermined number of configurable waveforms are generated. Waveform generation may be interrupted, at least temporarily, including during / event-based time. Therefore, in certain embodiments, the ability to essentially reset circuit 800 is as described above / this This enables more robust operation detection schemes, as discussed in the specification.

[0174] In addition, referring further to Figure 8B, in certain embodiments, periods 845, 855, and The durations of each of the 865 can vary collectively or independently. For example, the duration of period 8 45 and 865 can be considered active (e.g., default) states, with a duration of 855. This can be considered a reset or inactive state with respect to pulse generation. For example, A Active state (e.g., during periods 845 and / or 865) and reset state (e.g.) For example, the duration or duty cycle (for a period of 855) may vary depending on the circumstances. For some reason, it may be configurable. In some cases, the duty cycle of circuit 800 It may remain in a reset state longer than it is in an active state, or vice versa. It can be configured to be offset.

[0175] For example, in some situations, the reset cycle duration is increased compared to the active state. Adding this may be beneficial. This is between two consecutive active cycles (for example, (Between the end of period 845 and the beginning of period 865) enough time to discharge more completely. This allows for better capacitance of the analyte sensor 808. This results in greater consistency. Repeatable and / or accurately detectable initial charge current response and corresponding current Pressure pulse waveforms can be easily obtained. Here, referring to Figure 8B, any number of waveforms 870, 8 Note that 80 may be repeated. The length of the reset state between various such waveforms. For example, the waveform fluctuates between two sets of waveforms associated with an active state. Obtain. In some cases, the length of the reset state(s) is configurable, variable. It may be adaptable and / or programmable, for example, the length may vary over a certain period of time. After the period has passed and / or as described herein, the analyte sensor system 30 In the presence of other conditions that can be monitored using 8 (e.g., accelerometer or hydration-related conditions) In response to the detection circuit 802 not triggering the operation of the analysis sensor system 308, It can be transformed. In addition, the length of the active (or reset) state is determined by the time it has been in the active state. Changes between active states (or from reset state to reset state), or by any other criterion. It is possible.

[0176] In one example, when switch element 812 is closed and switch element 814 is open, Circuit 800 can be in an active state, when the switch element 814 is closed, When switch element 812 is open, circuit 800 can be in a reset state. In this example, the analyte sensor 808 can be disconnected / separated from terminal 824. Therefore, there may be no power supplied to the analyte sensor 808. At the same time, the switch Element 814, when closed, can optionally function as a resistive element (for example, as a current limiter). Terminals 828 and 830 can be connected / coupled to each other via 832. In this way, The charge that may be stored in the capacitance of the analyte sensor 808 is transmitted through this path to terminal 828. A switching element that can be used to couple to a quasi-voltage 818 (e.g., ground). In conjunction with the continuous / progressive toggle of 816, the switch element 814 and an optional resistive element It can be discharged at least substantially by the path that can be created by child 832. If terminal 824 of vice 810 is isolated from the rest of the elements of circuit 800, then capacitive element Since there is no new charging current source for child 834, the charge that can be stored in capacitive element 834 is also Under these conditions (for example, during this period), it can be discharged at least substantially.

[0177] Advantageously, circuit 800 can be used in conjunction with the circuit model shown in Figure 7A, etc. In such cases, detection can be made sufficiently, reliably, and / or accurately using the detection circuit 802. Voltage waveforms (one or more) (see, for example, waveforms 870 and 880 in Figure 8B) A repeatable / consistent and / or controllable / configurable machine for generating This can result from the meeting. Due to several possible circumstances (for example, the analyte sensor 80 If 8 is not sufficiently hydrated, etc., the analyte system 308 uses circuit 800. If no initial current rush is detected, the circuit 800 may be affected in the manner described above. Number of detections between subsequent active cycles following a set cycle(s) Route 802 may allow for additional attempts / opportunities for detection by the analyte sensor 808.

[0178] Figure 8C shows the control of the operation of the analyte sensor system 308 according to an embodiment of the present disclosure. This is an operational flowchart illustrating method 850. Method 850 is shown in relation to Figure 8A. Method 850 is described below with reference to specific circuit diagram elements considered, but it is not necessarily It should not be understood that this configuration / element is limited to this type. The operation of Method 850 is It may also be used in connection with a robust operating scheme for the precipitate sensor system 308.

[0179] In operation 852, method 850 is that the detection circuit 802 monitors the analyte sensor 808. For example, this may involve monitoring the voltage present at the input terminal 822 of the detection unit 802. The input terminal 822 can be coupled to the second terminal 830 of the analyte sensor 808. Sensor 808 is used to monitor the electrical characteristics of the analyte sensor 808, and measuring device 810 It can be coupled to (for example, a potentiostat or other measuring circuit). Method 850 is, In operation 854, the switch element 816 is used to input terminal 822 of detection circuit 802. This may include coupling to a reference voltage 818 (e.g., ground). Switch element 816 This is one or more from the driver circuit 806 (e.g., clock or other signal drivers). It can be controlled and / or driven using signals.

[0180] In operation 860, method 850 is when one or more measurements are taken at input terminal 822 of detection circuit 802. This may involve determining whether a condition is met. For example, such a condition may involve checking The input terminal 822 of the output circuit 802 is at the threshold voltage (for example, referring to Figure 8B as an example, the threshold voltage). 848) Whether it has reached, exceeded, or crossed the threshold voltage. , or (for example, as mentioned above in relation to Figure 8B) over a number of different periods, what This may include whether another characteristic is achieved, such as satisfying a threshold of 848, multiple times or more. In this embodiment, the condition / characteristic is that when the input terminal 822 of the detection circuit 802 reaches the threshold voltage... It is either above the threshold voltage, crossing the threshold voltage, or holding a certain value. A consistent frequency of positive determinations that present a voltage that achieves a different condition over a period of time. This includes, and therefore can help ensure that the condition is not reached based on the anomaly.

[0181] For example, operation 860 sets the voltage at the input terminal 822 of the detection circuit to a threshold (for example, Refer to Figure 8A, and it may be accompanied by comparison with a reference voltage 804). For example, detection The voltage at input terminal 822 of circuit 802 is the same as the voltage at the first terminal 828 of the analyzer sensor 808. This can indicate the current that can flow between the second terminal 830 and the other terminal. As discussed above, in a specific example, The detection circuit 802 measures the terminals 828 and 830 at both ends of the analyzer sensor 808. Whether the voltage can achieve the characteristic or satisfy the characteristic (e.g., exceed the threshold) Amplifiers, comparators, etc., which can be used to detect this, and / or This can be detected. In the embodiment, the characteristic (e.g., threshold voltage) is the reference terminal of the detection circuit 802. It can be set using a reference voltage 804 which can be applied to 820.

[0182] If one or more conditions are met, method 850 operates at a lower power level in operation 862. This may further include triggering the analyzer sensor system 308 to terminate the state. For example, the analyte sensor system 308 uses circuit 800 (see Figure 8A as an example). The determination is made, and as indicated by output 836, one or more conditions are met. As a result, it may be triggered to terminate the lower power state. However, one or more If the conditions are not met, method 850 is (for example, in relation to Figures 8A and 8B) As described above, the switch elements 812 and 814 are controlled in relation to the analyte sensor 808. Operation 858 may include an operation 858 that involves discharging, at least substantially, the attached capacitance. Next, method 850 is that the analyte sensor system 308 remains in a lower power state. This may be accompanied by a return to operation 852.

[0183] Therefore, operation 858 periodically controls the capacitance of the analyte sensor 808 to at least a substantial degree. This may involve causing the switch elements 812 and 814 to discharge in a specific manner, and the first At this point, switch 812 is effectively closed or in a low impedance state. Therefore, the first terminal 828 of the analyte sensor 808 is connected to the measuring device 810. It can be used for the following: And at the second point, the switch element 812 is connected to the analyte sensor 80 The first terminal 828 of 8 is effectively opened to isolate it significantly from the measuring device 810. Alternatively, it can be put into a high impedance state, while the switching element 814 can be (for example, i In some cases, the analyte sensor (via the resistor element 834 which can be used as a current limiter) The first terminal 828 and the second terminal 830 of the SA808 are connected to each other, and the analyte sensor 80 The capacitance of circuit 8 and / or circuit 800 can be discharged at least substantially. As discussed above, operation 858 determines that the current that can flow through the capacitance of the analyte sensor 808 is Generally, the circuit 800 can be effectively reset to the measurement state, and therefore another Enables detectable events, and the analyte sensor system 308 provides a robust action detector. It can provide a structure.

[0184] Referring further to Figure 5, it may be used for the purpose of activating the analyte sensor system 308. Another method is voltage generation. In this embodiment, the transcutaneous portion of the analyte sensor 530 is used A small voltage can be electrochemically generated. That is, the analyte sensor 530 is inserted. The host body enables chemical reactions that generate electrical energy, similar to those in a battery. It can be used as an electrolytic medium. For example, it can use electrolytes in the body to transfer electrons in chemical reactions. This generates a detectable voltage, which is then monitored and used to terminate lower power states. The analyte sensor system 308 can be triggered in this manner.

[0185] Use of other signals to terminate lower power states According to embodiments, an additional aspect of the present disclosure is a pre-connected analyte sensor system 30 For the purpose of operation in 8, (see Figure 5 as an example) secondary sensors other than the analyte sensor 530 This involves the use of sensors or means. Various events are analyzed by the analyte sensor system 308. This may be detectable by the embedded analyte sensor 530, and such an event indicates the embedding of the analyte sensor 530. An example is the separation of the analyte sensor system 308 from the applicator, and the analyte sensor System 308 separates from packaging and analyzes the host or user. This includes detecting the proximity of the object sensor system 308. These events or fe Changes in the sensor are detected using multiple different sensor types, as described below. obtain.

[0186] The first category of sensor types that can be used to detect embedded events is The operation detection circuit 520 is used in the analyte sensor system 308 without the use of additional components. This involves using one or more signals generated by the components included in it. Sensors in this category can be integrated into the analyte sensor system 308, thus reducing costs. It has advantages because it is less complex and usually does not require user interaction.

[0187] An example of a technique in the first category of sensor types is the analyte sensor system 308. A proximity sensor is used for the purpose of activation. Such a sensor is the analyte sensor system 3. The distance between 08 and the reference point and / or the change in distance can be detected or estimated. The reference point is the host, the applicator of the analyte sensor system 308, and the analyte sensor system. 308 packaging, or it could be another object. Referring to Figure 5, the proximity sensor is Using one or more of the operation detection circuit 520 and the operation detection component 545, It can be fitted.

[0188] In this embodiment, the proximity sensor may be implemented using capacitive sensing. For example, operation detection cycle The path 520 detects conductive objects, or other objects having a dielectric constant different from air, and / Alternatively, it may include a capacitively coupled circuit that can measure capacitance. In connection with this, two capacitance sensing circuits The type can be used.

[0189] The first type of capacitance detection involves detecting the mutual capacitance between a capacitively coupled circuit and another object. This may involve, for example, the host or user's fingers, the host or user's skin, or the application. The other object, such as the base plate of the unit or any other object, is the actuation detection component. The interaction between electrodes that may be included in component 545 can be modified. Actuation detection component 545 This modification or change in interconnection is transmitted to the operation detection circuit 520, resulting in a lower power state. An operational event can be triggered that causes the analyzer sensor system 308 to terminate the state. In the embodiment, capacitive coupling monitoring is performed when the analyte sensor system 308 is in a lower power state. Please note that this will take place during the period.

[0190] The second type of capacitance detection may involve self-capacitance or absolute capacitance. For example, the user's fingers or skin, or the applicator's base plate (see below for details). Objects such as those shown in Figures 6A and 6B (details below) have capacitance to ground. Increase the parasitic capacitance of the sensor to increase the capacitance of the capacitance sensor of the operation detection component 545. This may increase the capacity load. This capacity load event triggers an operational event. Therefore, it can be transmitted to the operation detection circuit 520.

[0191] In this embodiment, the proximity sensor may be implemented using guided sensing. Using guided sensing, A non-contact electronic proximity sensor can be implemented. The sensor is part of the analyte sensor system 308. Metal parts may be located on one or more parts of the actuation detection component 545 within the applicator. It can be used for positioning and detecting other conductive objects. Here, as an example, Figure 6A and See also Figure 6B. The induction-based proximity sensor of the action detection component 545 is It may include an inductive loop. Current typically generates a magnetic field. When the magnetic field changes, the field changes. This can generate an electric current. The inductance of the loop is such that the proximity of a metal object affects the electric current flowing through the loop. It can be changed by altering the flow. The change in inductance is detected by the operation detection circuit 520. Detection may be performed using a detection circuit that may be included in the operation detection component 545. This can be done, and this change can be used to terminate the lower power state of the analyte sensor system. It can trigger M308.

[0192] Another approach to implementing proximity sensors is to use magnetic detectors and / or sensors. Therefore, the embodiment of the operation detection component 545 is an analyte sensor. Within the packaging of the Tem 308, within the applicator of the analyte sensor system 308 (for example) (See Figures 6A and 6B), or interact with the user's analyte values, and / or Can be placed on or within a display device used to display analyte values Includes a magnet. The proximity sensor detects the magnetic field (e.g., Hall effect sensor, lead switch). Based on the presence or absence of (such as a tweak), the operation of the analyte sensor 308 is triggered. It can be configured. Next, the presence or absence of the detected magnetic field is used to determine a lower power state. The analyte sensor system 308 can be triggered to terminate. More specifically, In some embodiments, magnetic-based sensors utilize the Hall effect and lead generation for operational purposes. A switch or other magnetic means may be used. For example, the analyte sensor system 308 The prepulator, or the user interacts with information related to the analyte sensor system 308. Display devices configured to enable viewing and / or browsing of information The upper component (e.g., needle hub, spring, needle, or applicator body) is magnetized. It may also include a magnet. Deployment of the analyte sensor system 308, applicator Removal of the analyte sensor system 308 from the data, or against the analyte sensor system 308 The movement caused by the movement of such display devices is transmitted by magnetic-based sensors. This can trigger it.

[0193] For example, when the analyte sensor system 308 is deployed, the analyte sensor system 308 A conductive flexible pack may be designed to make contact with the corresponding split connector. When the pack makes contact with the split connector, a short circuit is formed, and through impedance measurement, Alternatively, it activates after detecting a short circuit through the resulting connection to a power source (e.g., a battery). The analyte sensor system 308 can perform this task. For example, using a pack, pull a A pull-down circuit may be triggered. In another example, processor 535 triggers a read switch It can monitor interrupt signals from switches or Hall effect switches, and its interrupt The signal is transmitted within the applicator of the analyte sensor system 308, or through its packaging. This can be generated when the switch is no longer close enough to the magnet that may be placed inside the device.

[0194] Figures 6D and 6E show the analyte sensor electronics that may be included in the operation detection component 545. A top view of each exemplary embodiment of the split connectors 640 and 650 of module 12. Figure 6D shows an exemplary implementation of a split connector 640 having a generally axially symmetrical layout. In its configuration, connector 640 is divided into two semicircular partial contacts 642a and 642b. Figure 6E shows an exemplary split connector 650 having a generally concentric (coaxial) design. The image shows a top view of the configuration, where the first partial contact 652a is connected by the second partial contact 652b. It is surrounded. A space is provided between contacts 652a and 652b, and contacts 652a and 6 52b can be insulated from each other.

[0195] In some embodiments, while in a lower power mode, the analyte sensor system 308 The interrupt signal from the reed switch can be monitored. In this embodiment, the switch is second When the switch is set to a certain state (for example, the open state), an interrupt signal is sent from the reed switch, This occurs when the magnet is no longer close enough to the reed switch, and the reed switch is moved to the second position. It can be maintained in state 1. For example, the magnet is near the operating detection component 545 during manufacturing. The analyte sensor system 308 is positioned in the package of the analyte sensor system 308. Applicator for sizing or in containers, and / or for analyte sensor system 308 While inside, the analyte sensor system 308 can be kept in a lower power mode. Using the analyte sensor system 308 and the analyte sensor 530 to the user / host If embedding is desired, the analyte sensor system 308 can be placed in the container and / or package. The magnet can be removed from the housing, and accordingly, the operating detection component 54 The analyte sensor system 308 moves away from the vicinity of 5 and therefore triggers the operation. This can be done by reed switches, Hall effect switches, etc., for analyte sensors. The analyzer sensor system 308 is inherent in the Tem 308 to terminate lower power states. The actuation detection component 545 can be made to trigger the actuation, for example. For example, the product packaging of the analyte sensor system 308 Once removed from, it can be performed. Also, the analyte sensor system 308 is in the applicator. The switch may be activated if it is moved to a position that avoids close proximity.

[0196] In some embodiments, a magnet is used to cause a magnetic sensor to change its state. When brought close enough, an interrupt signal is generated, and the magnetic sensor, such as a reed switch, It is transmitted from, for example, the display devices 110, 120, 130 and shown in Figure 1. 140 to one of the magnets (for example, a thin 10-30 mil self-adhesive magnet or magnetic stab) A cker may be attached. In some implementations, the user can, for example, add it upon request. To obtain one or more analyte concentration values ​​(e.g., glucose concentration value), an analyte sensor is used. If you want to wake up Stem 308, the user needs to make the magnetic sensor change state. The magnet touches the analyte sensor system 308 attached to the display device, or the magnet It can be brought close enough to the analyte sensor system 308. In some embodiments, A magnetic sensor detects the different relative motions of a magnet and / or the magnetic field of a magnet relative to the magnetic sensor, and the air. They may be configured to distinguish between orientation and / or positional alignment. For example, a magnet may be a multipole magnet. It may contain stones, and / or magnetic sensors may be magnets or magnetic fields and magnetic sensors The specific predetermined relative movement of the sensor and / or display devices 110, 120, 130, 140 Start a wake-up signal or otherwise trigger it in response to motion and / or spatial orientation. It can be configured to respond to a change in the state of the magnetic sensor, from a low power consumption mode. A wake-up device configured to cause the analyte sensor system 308 to wake up The hop signal can be triggered. When waking from a lower power consumption mode, The precipitate sensor system 308 initiates a wireless communication protocol (e.g., BLE), and / or may be configured to power on the associated chip. The transceiver 510 is For example, by transmitting one or more advertisement packets, advertising can be initiated. It can be configured in such a way. In some embodiments, the advertised packet is specific It must contain one or more codes and / or patterns specific to the wake-up protocol. This is possible. Display devices 110, 120, 130, and 140 receive the advertisement packets. The system can transmit the request for analyte concentration values ​​to the transceiver 510. The TEM308 displays one or more analyte concentration values ​​using the display devices 110, 120, 130, and 140. It can be configured to transmit to the analyte sensor. When one or more analyte concentration values ​​are transmitted, the analyte sensor System 308 stops transmitting advertised messages to reduce power consumption. It can be configured to return to mode in response to receiving one or more analyte concentration values. Display devices 110, 120, 130, and 140 show analyte concentration values ​​(single or multiple). Short messages indicating to the user that they were received by display devices 110, 120, 130, and 140. It may be configured to play an audio clip or sound. Such embodiments are implemented Very low cost, minimal impact on battery life, and even those that do not use specific communication protocols. Compatibility with the intended type of display device, display devices 110, 120, 130, 140 This includes, but is not limited to, providing solutions that minimize the impact on aesthetics, several This could be advantageous for that reason.

[0197] In the embodiment, acoustic and / or voice detection is used in the analyte sensor system 308 It is possible to detect proximity between and a reference point. For example, the operation detection circuit 520 and / or Alternatively, the motion detection component 545 may be an ultrasonic or voice-based proximity sensor, for example. Using the Doppler effect, the applicator or packing is used to connect objects and analytes to the sensor. One or more microphones capable of detecting relative movement between them and system 308 It may include a speaker and / or a lower The analyte sensor system 308 can be triggered to terminate the power state. Example In this manner, it indicates that embedding is being performed or is about to be performed. The precipitate sensor system 308 moves away from the applicator or packaging. Using acoustic / speech detection, a frequency shift in an ultrasonic or speech signal can be detected. It may be output. In some embodiments, frequency shift is required for detection / operation purposes. It is not necessary. Rather, the presence or absence of audio / acoustic signal transmission is important for the analyte sensor system. It can be used to trigger the operation of the 308, or for audio / The presence of an acoustic signal can be used for operational purposes.

[0198] Temperature-based detection approaches are a first category of sensor types (e.g., analyte sensors). Another electromechanical method in system 308 (without using external components) For example, it can be used in addition to, or as an alternative to, proximity-based methods. Here, one or more The temperature sensor can be coupled to a printed circuit board, chip, etc. For example, operation detection Output component 545 is a temperature sensor that can use thermistors, thermocouples, etc. It may include. The temperature sensor of the operational detection component 545 is included in the analyte sensor system 308. It can be implemented internally and / or externally to the analyte sensor system 308.

[0199] A temperature sensor can measure temperature changes in a single location (for example, temperature changes, or temperature compared to a threshold), Alternatively, to detect a temperature gradient, multiple locations (for example, multiple temperature sensors, spaced apart) It can be configured to detect temperature (and can be used in different locations that are known to be different). In some cases, temperature is used to infer contact and / or proximity to the user's body. It is possible. For example, when the temperature approaches the normal temperature of the human body, proximity to the user It can be shown. Gradient measurement can be used to estimate heating or cooling from a known direction. Therefore, for example, the analyte sensor system 308 or another object that emits heat (e.g., The direction of movement of the host's body, or the direction of movement towards or away from the human body. It can be used to infer direction. Therefore, the detected temperature or temperature profile Use the trigger to end the lower power state of the analyte sensor system 308. It is possible.

[0200] In this embodiment, the operation detection circuit 520 and / or operation detection component 545 are The movement and orientation of the analyte sensor system 308 are monitored, and the embedded analyte sensor 530 One or more accelerometers may be used to detect one or more events indicating an insertion. This may include a gyroscope. One such event is, for example, the analyzer sensor 5. Resulting from a spring-operated applicator mechanism that can be used in connection with the embedding of 30 The obtained analyte may be accompanied by a relatively sudden increase in the acceleration of the sensor system 308 (here, for example, (See, for example, Figures 6A and 6B). Another such event is analyte sensing. This includes deceleration from stem 308 and may affect the user's skin surface (e.g., embedded (Colliding with the user during the collision). In this embodiment, both acceleration and deceleration events are used. This increases robustness, detects events related to movement, and / or analyzes the sample. This can trigger the operation of system 308.

[0201] One potential concern with accelerometer-based and other deployment-based operating methods is power consumption. It is a quantity. For example, the amount of power used to monitor an accelerometer signal is the amount of power used for monitoring. The sampling frequency may be proportional. Insertion / embedding of the analyte sensor 10 is usually proportional. Because it is performed over a relatively short period (e.g., 30 milliseconds), it ensures reliable detection of the embedding. To achieve this, a relatively high sampling frequency (e.g., 5 milliseconds) may be required. Such relatively high sampling frequencies can accommodate higher power consumption. Therefore, Embodiments of this disclosure use an accelerometer to control acceleration / deceleration and other functions while maintaining power efficiency. The goal is to accurately capture events related to movement.

[0202] In an exemplary embodiment, an accelerometer is used to detect the deployment of the analyte sensor system 308. The sampling frequency used to monitor signals from other means can be varied. This is possible. For example, it is possible to respond to an event that will show the future development of the analyte sensor system 308. In response, to monitor the accelerometer signal in a power-efficient manner, a lower sampling frequency is used. Numbers can be used. Such events include, for example, when a user performs an analyte sensor. Unpacking the Tem 308, the user's package associated with the analyte sensor system 308 To release the casing, and / or (for example, hospitals, clinics, users' homes, etc.) Or other such locations that can be determined using location services such as GPS. By the way, and / or at a particular time and / or by the user, the preferred or analyte sensor Installation / deployment of the analyte sensor system 308 on the day of normal deployment of system 308 This may include the user being present at the location / time typically associated with the embedding.

[0203] Additional events that may be used to indicate future developments of the analyte sensor system 308 are: (1) Applicator safety card (for example, to enable the trigger on the applicator or (Plastic components that are removed) or fragile parts (for example, parts that can trigger) (A fragile part on the applicator trigger that must be removed in order to do so.) (1) Removal of applicator safety mechanisms such as (2) Push / force applied to the applicator (e.g.) The applicator is positioned on the surface (e.g., skin surface) with minimal force to enable triggering. (3) Breakage of fragile components (e.g., plastic carbonated beverages) (Similar to the safety ring on the container), (4) partial rotation of the threaded safety ring, (5) integrated Apply pressure to the side trigger button and / or (6) various other safety locks A mechanism may be, or may include, a sampler that can be used for monitoring accelerometers. Another approach to changing the frequency could be detected using an accelerometer, from the user. This may involve direct or indirect haptic input (for example, the user is sensing the analyte sensor). (By tapping system 308, you can transition to a higher sampling frequency.) Let's examine this in more detail below.

[0204] The safety lock mechanism may be configured to be activated / triggered by the user, but several In that embodiment, the pre-energized system is, for example, the pre-energized spring A safety lock mechanism can also be used to prevent premature triggering or activation.

[0205] These trigger events for the accelerometer or other action detection means are detected by the analyte sensor. This causes a transition in the sampling frequency used by Stem 308, which is relatively more Accelerometers or The output signal of other operating means can be monitored, and one or more higher sampling frequencies can be used to analyze the analyte. Motion triggers or other actions performed over a relatively short period, such as embedding the sensor 530. Events can be detected / captured more reliably. By varying the sampling frequency... This allows for accurate measurement using accelerometers or other methods as described herein. Lower amounts of power may be used while still maintaining event detection.

[0206] The use of events related to positive / affirmative movement has been described above, but the analyte sensor It can be used to trigger the operation of system 308 or to monitor the accelerometer. To change the sampling frequency or frequency, events related to negative motion occur. It should also be understood that it may be used to describe movement, orientation, or a specific place or location. Using the absence of this type of signal, it may be possible to trigger a lower sampling frequency or frequency. For example, if the analyte sensor system 308 was relatively inactive for a long period of time, or compared If the object remains in the same position / orientation for an extended period, a lower sampling frequency may be used. As an additional example, the analyte sensor system 308 uses (e.g., GPS, A-GPS, position detection) (Based on user check-in, or using other location services) storage facilities If it is determined that the location is set, a lower sampling frequency may be used. When the conditions indicate that embedding is less likely to occur, the accuracy of embedding detection is improved. It may be possible to save electricity without making any sacrifices.

[0207] Figure 9 shows how to reduce power consumption and / or accurately detect the embedding of the analyte sensor 530. To obtain this, an accelerometer-type or other detection scheme using a variable sampling frequency is used. This provides an exemplary plot illustrating the operation of the connected analyte sensor system 308, and at the same time, The ability to reliably operate the analyte sensor system 308 and avoid false wake-ups. To maintain (for example, for more reliable calculation of analyte values). For example, accelerometer signals The sampling frequency should be power-efficient (for example, 1 second, 2 seconds, depending on the application). (Used for seconds, 5 seconds, 30 seconds, 1 minute, over 1 minute), and not limited to, the package Unpacking or opening the packaging, locating the installation area, and ensuring the applicator is secure. Detect events such as removal and / or motion associated with the applicator's trigger. It is possible. When detected, such events can be used to sample the accelerometer more frequently. It can be set to (for example, 1000 milliseconds, 500 milliseconds, 250 milliseconds, 100 milliseconds) (e.g., milliseconds, 50 milliseconds, 10 milliseconds), the higher the frequency, the more reliable the motion trigger event. Indeed, it can be captured. In exchange for, or in addition to, the relative motion or orientation. Events with a specific lack may be detected, and in certain cases, such events may be used. Then, a lower sampling frequency may be triggered.

[0208] Plot 900 shows the analyte sensor system plotted against time (e.g., seconds). Represents one or more operating states of the M308. For example, one or more operating states of the analyte sensor This may include the non-triggered and triggered states of stem 308. The non-triggered state may be in various cases. So, inactive or effectively inactive state, lower power state, sleep Modes, and / or similar things may or may be included. Plot 9 At point 902 of 00, the analyte sensor system 308 detects the analyte within the host. A measuring device that may be used in connection with this (e.g., a potentiostat) is a specific input. It can respond to events. For example, when the analyte sensor system 308 is in a non-triggered state. One or more electrodes of the analyte sensor 530 are voltage-biased and / or the analyte is It can be used to measure or collect information related to the analyte. In this configuration, one or more electrodes of the analyte sensor 530 are not biased while in a non-triggered state. It is important to understand that this is not necessary. For example, electrode bias is not necessary in some cases. This can be greatly reduced or avoided during the Riga condition. This is because monitoring as described herein This can be based on the observed environment or other conditions, predetermined variables or settings, etc.

[0209] At point 904, the analyte sensor system 308 is shown in the triggered state. In various cases, the RIGA state is when the analyte sensor system 308 is active or substantial. It can be considered to be in an active state. Trigger state of analyte sensor system 308 In an exemplary implementation, the analyte sensor 530 is voltage-biased using a measuring device. The analyte can be obtained or otherwise measured / characterized. Furthermore, the analyte When the sensor system 308 is in the trigger state, other components of the analyte sensor system 308 The interface may be operated, for example, the connection interface 505 may receive / transmit data. For example, processor 535 may perform various operations. Region 910 of 900 is between the non-triggered state and the triggered state of the analyte sensor system 308. This illustrates an example of a transition.

[0210] As further shown in Figure 9, plot 912 shows the operation of the analyte sensor system 308. Examples of signals that can be used in relation to changing a state / state versus time (e.g., seconds) are shown. It is possible to monitor the signal (e.g., over time) and use it with the analyte sensor system 308. , one or more components of the analyte sensor system 308, and / or analyte sensor Does it change the operating status / state of the circuit in the operation detection circuit 520 of the system 308? or can be controlled in other ways. For example, such components and / Alternatively, using a circuit, acceleration can be used in conjunction with the actuation detection component 545. The output signal from a meter or other operation detection means can be monitored.

[0211] In the time domain 916, for example, the signal is a first value or relatively close to a first value. (For example, although a relatively lower value is shown in Figure 9, the first value is relatively higher) (Please understand that it can be any value). In addition to this, or instead of this, the signal is observed This includes, and may be detected, other different values, trends, frequencies, slopes, gradients, etc. It may be used to be / to transmit. For example, the first value, etc., can be absolute or self. On a relative basis, and / or different time regions such as those illustrated in plot 912. It can be compared / measured against other values / characteristics of the signal that may occur in the region, such as the first value of the signal. Using the analyte sensor system 308, the components of the analyte sensor system 308 This can indicate that the monitoring circuit can be kept in a non-triggered state.

[0212] And, for example, in the time domain 914, the signal is the second value or relatively close to the second value. (For example, in Figure 9, a relatively higher value is shown, but the second value is a ratio) (Please understand that the value may be relatively lower.) In addition to this, or instead, The signal may be observed / detected as having different values, trends, frequencies, slopes, gradients, and in other cases. It may include and / or be used to convey things like / or similar things. For example, the second value, etc., is plotted in Figure 9 on an absolute or self-relative basis. For other values / characteristics of signals that can occur in different time domains, such as those shown in Figure 2 , can be compared / measured. The second value, for example, can be used alone or, for example, with the first value and / or This is used in combination with other variables / conditions, for the analyte sensor system 308, analyte sensor One or more components of system 308, and / or monitoring circuits, for example, analyze Object sensor system 308, components of analyte sensor system 308, and / or The monitoring circuit can be kept in a non-triggered state, but is used in relation to the operation detection component 545 More actively monitoring output signals from accelerometers and / or other actuation detection means that may be used. It is possible.

[0213] Figure 9 also shows plot 912, which represents the sampling period that may be used before the occurrence of trigger 906. The diagram illustrates that it may include interval 918. In response to trigger 906, sampling period 9 It can be shorter than 18 (for example, representing a higher sampling frequency) A pumping period of 920 may be used. For example, the trigger 906 is used in the analyte sensor system. Unpacking M308, or associating it with any other trigger event described herein. This could be an acceleration / deceleration event. Using a shorter sampling period of 920, The monitoring circuit, represented here by trigger 908 as an example, now monitors the analyte sensor 530. Later, currently occurring, or past embeddings associated with motion-based and / or movement-based movements Alternatively, it may become possible to detect other events. In response to trigger 908, the analyte... Sensor system 308, components of analyte sensor system 308, measuring device, The and / or monitoring circuit transitions from the non-trigger state 902 through the transition region 910 to the trigger state 90 It transitioned to 4. Trigger 908 is, for example, a lower power state of the analyte sensor system 308. It may initiate a transition from a state to a more active state.

[0214] In this embodiment, a wireless / antenna type is used to operate the analyte sensor system 308. A method may be used. For example, the action detection component 545 has a part that detects the analyte. It may be located inside the system 308, and / or a part thereof, the analyte sensor system N may be located outside of M 308 and may be positioned in close proximity to the analyte sensor system 308. It may include components such as FC or RFID tags. For example, such a tag is , within the applicator of the analyte sensor system 308, or the analyte sensor system 308 It can be located within the packaging (see, for example, Figures 6A and 6B). Analyte sensor System 308 may query tags at regular intervals to establish proximity relationships. For example, the analyte sensor system 308 pings or other messages to / from the tag. A transmitter, which may be part of the transceiver 510, can be used to transmit / receive signals. The precipitate sensor system 308 receives a response to a ping or other message / signal. In this case, the lack of response indicates the deployment of the analyte sensor system 308 (e.g., analyte sensor 53). (Insertion of 0), and therefore can be used to indicate a trigger to exit a lower power mode. In an embodiment in which the analyte sensor system 308 continues to send ping messages after deployment, The analyte sensor system 308 receives an input (for example, connected) indicating that deployment is taking place. (Received via the GUI of the display device 310) and as a result, send a ping message You can stop believing. In some cases, the tag is the analyte sensor system It may be an active component that pings M308 or the operation detection component. In such cases, the analyte sensor system 308 stops receiving pings from the tag. If stopped, the lack of received ping messages will be used to control the analyte sensor system 30 This could lead to a development of 8.

[0215] In an exemplary embodiment, the deployment or packaging of the analyte sensor system 308 is shown. During the removal of these, the analyte sensor system 308 and NFC or RFID are used. It can detect changes in the proximity relationship between a reference point such as packaging, and use the changes to further... The analyte sensor system 308 may be triggered to terminate the low power state. Modifications may also be made to, for example, RSSI or other channel measurements that can indicate proximity from a reference point. Any of these measurements can be detected using the measurements that can be performed by the transceiver 510. Estimation between the reference location and the analyte sensor system 308 using (for example, RSSI) When the distance satisfies conditions such as a specific threshold distance, the lower power state is terminated. The analyte sensor system 308 can be triggered in this manner. In addition, in certain embodiments, NF Using C, separate wake-up commands (for example, from one or more display devices) Provided to the analyte sensor system 308, to activate the analyte sensor system 308. Yes, it is possible. Alternatively, the lack of NFC ping, or NFC ping requiring a specific power level Using the downward descent indicates a lack of proximity, and therefore, the analyte sensor system This can trigger the operation of unit 308.

[0216] In another example, the analyte sensor system 308 utilizes radio frequency echoes to achieve lower frequencies. The analyte sensor system 308 may be triggered to terminate the power state. For example, the analyte The sensor system 308 intermittently emits an RF signal using the transceiver 510, given The environment (e.g., within the packaging or applicator) is known (e.g., For parameters that can be characterized in a certain way, their echoes can be monitored. The data may include, for example, signal intensity, Doppler, distance, density, and material. When the radiation and the resulting echo change, this is used to trigger the action. This may indicate possible environmental changes. Therefore, embodiments use radio waves to detect environmental changes. The analyte sensor system 308 is then exposed to the bounce back of the transmitted signal around it. Determine the range, angle, or velocity of an object and characterize it (e.g., how it changes) within its surrounding environment. This is accompanied by, for example, the surrounding environment can be characterized by measuring the phase angle, etc. RF emission One example of a ray is one involving BLE (Bluetooth® Low Energy). To obtain. For example, one or more radio sources broadcast radio signals from one or more specific locations. It can be cast. The wireless source (one or more) is the analyte sensor system (one or more). 308 may be stored in one or more facilities or other locations, or in an analyte sensor system ( It may be localized to the manufacturing location associated with (singular or plural) 308. In some cases The wireless source (one or more) is a BLE source or RF source as described herein. This is possible. In the embodiment, the analyte sensor system 308 (for example, located in a storage facility) (The intermediary) monitors or listens to broadcasted wireless signals or signal characteristics and receives If the broadcast signal characteristics (e.g., signal strength or other aspects) exceed a threshold, It can be configured to determine whether it is below or near a threshold. Based on this, the analyte sensor system 308 is activated from a lower power / sleep mode. The system may or may not transition to a submode. For example, the received signal characteristics... If the threshold is exceeded (for example, if the analyte sensor system 308 is still in the storage facility) (This may indicate that) the analyte sensor system 308 is in a lower power mode or three It may remain in push / shelf mode. In another example, the analyte sensor system 308 may be in a different When the analyte is moved to a different location (for example, the patient's home or office, or a distant storage facility), The sensor system 308 can determine that the monitored signal characteristics are below a threshold. Therefore, the analyte sensor system 308 then switches from a lower power mode to an active mode. It may transition to a code or operating mode.

[0217] In this embodiment, the activation detection component 545 activates the analyte sensor system 308. Includes pneumatic sensors that may be used in connection with causing this. For example, an actuation detection component. The T545 may include a barometric pressure sensor that can be configured to detect changes in atmospheric pressure. The analyzer sensor system 308, along with the analyzer sensor system 308, is used under conditions exceeding standard normal atmospheric pressure (for example, 1 Stored in pressurized packaging (higher than atmospheric pressure) or lower than atmospheric pressure (e.g., vacuum). Obtain. Next, the act of breaking the packaging associated with the analyte sensor system 308 ( For example, opening, perforation, etc., can result in changes in pressure. Next, pressure transition events When the packaging is broken and the pressure changes, the analyte sensor system 308 It can be used as a detectable event to trigger operation. Analytical Sensor System 308 is a moisture-proof volume within the analyte sensor system 308 (e.g., sensor measuring electronic device housing). A flexible part (for example) that can enable the detection of pressure changes outside the sing within the moisture-proof volume. The analyte sensor system 308 may be configured to have a diaphragm. When supplied in a pack configuration, each analyte sensor system 308 in the multipack will provide each analysis The object sensor system 308 can individually terminate lower power states based on pressure changes. The packaging may have individual pressurized chambers.

[0218] In this embodiment, the operation detection component 545 is located within the analyte sensor system 308. The system is positioned and detects an audio signal or signature indicating the deployment of the analyte sensor system 308. This includes microphones (e.g., passive or active devices) that may be used for this purpose. Then, the audio signal / signature is used by the applicator to deploy the analyte sensor system 308. This can be associated with (for example, applicator triggers, mechanisms, and user interactions). Such audio signals / signatures may be specific to the deployment event, and using audio signals / signatures This can be used to trigger the analyzer sensor system 308 to terminate the lower power state. It will become like that.

[0219] In some embodiments, the activation or wake-up of the analyte sensor system 308 is performed by the analyte sensor system 308. A display device configured to provide the user with information about the object sensor system 308. Based at least in part on the detection of sound or acoustic signatures indicating a successful deployment by The determination is based at least partially on the successful deployment of the analyte sensor system 308. This can be triggered. Such embodiments include early deployment failure detection and / or successful deployment detection. It can provide open detection. For example, a certain spring-loaded applicator can detect when unfolding. It can produce sound or have an acoustic signature, and then the applicator is opened. Alternatively, the timing of moving parts can be estimated without inspection. Therefore, for example, If the application runs on one of the display devices 110, 120, 130, or 140 When opened and executed, the failed analyte sensor system 308 successfully deployed. To distinguish between open and closed, and in some cases, to distinguish between sounds emitted by the applicator during deployment. By analyzing, it can be constructed to further infer the specific causes of the failed developments. In such an embodiment, the appropriate wake-up of the analyte sensor system 308 This only allows for alternative, supplementary methods to verify successful deployments in some cases. In addition, to investigate the cause of the failure, the defective applicator and / or analyzer sensor Without the need to return the system 308 to the manufacturer, it can be delivered to the site in near real-time. This makes it possible to troubleshoot the cause of specific deployment failures. The information at least allows for a review of the problems mapped to a specific application tarot. This will enable further innovation in the design of future applicators and analyte sensor systems. The costs associated with returning and investigating the faulty applicator. It may be valuable in that it can reduce [the problem].

[0220] In some embodiments, the display devices 110, 120, 130, 140 are microf The ions are emitted by the applicator and / or analyte sensor system 308 during deployment. A system is configured to generate a recording of one or more audio waveforms and / or spectrograms of the sound being produced. This can be achieved. Applications running on display devices 110, 120, 130, and 140 It analyzes one or more recorded waveforms and / or spectrograms, and based on the analysis Therefore, it can be configured to distinguish successful developments from unsuccessful developments. For example, an application The process involves the audio waveform and / or at a predetermined sampling rate (e.g., 96kHz). It may be configured to record a spectrogram, and the desired granularity over time of the development It is now possible to obtain (for example, sound with a range of 1 millisecond ± 0.025 milliseconds) (The ability to distinguish between and / or different forms of voice signatures). In some embodiments, the app The process involves an applicator and / or minute that performs known moves as part of the deployment process. Recorded waveforms and / or spectroscopic images showing specific components of the precipitate sensor system 308. Separate, correlate, and / or identify the parts of the gram, and such specific parts However, one or more factors related to the development that are sufficient to predict whether the development was successful or unsuccessful. Regarding other movements or sounds, at a specific speed and / or at an appropriate time, such Identify whether and / or when a known movement is being performed within the time frame. It can be configured to do so. Examples of such isolated sounds include the latching of parts and / Or one or more clicks indicating release from another part, and / or drive wheels or breeches. One or more percussive sounds or sound peaks indicating the movement, rotation, and / or stopping of the star are included. In some embodiments, when determining a failed deployment, The application then indicates a failed deployment, for example, to the user, "Remove the sensor." One or more notifications, or in lieu thereof, one or more communications to the user indicating a successful deployment. Knowledge can be provided to the user. In some embodiments, the deployment is deemed successful. The application then provides the user with one or more notifications indicating a successful deployment. It is possible.

[0221] The operation detection component 545 terminates the lower power state of the analyte sensor. This may include optical sensors that can be used to perform the operation on stem 308. Therefore, such optical sensors can be photovoltaic. Based on the exposure of the photosensor to photons... Then, a voltage can be generated. Next, the generated voltage can be compared to a threshold, and the result of that comparison is The result can be used to trigger the operation of the analyte sensor system 308. Therefore, the optical beam The sensor may use exposure for operational purposes. The sensor is part of the analyte sensor system 30. It may be located outside of 8, or, for example, within the analyte sensor system 308. How the analyzer sensor system 308 is designed so that light can still reach the optical sensor. The sing may be covered by an optically transparent portion. In this embodiment, the optical sensor is It can be triggered by exposure to normal sunlight conditions, or when light exposure meets a threshold condition. CMOS devices, CCD devices, photodiodes, photoresistors, and / Alternatively, it may include a phototransistor. Such an optical sensor is operated by the operation detection circuit 52 It may be considered part of the operation detection component 545, which is separate from 0, or It may be incorporated within the operation detection circuit 520. For example, a user equipment (UE) device (e.g. The display device 310) may be used to operate the analyte sensor system 308. It can provide an optical signal (for example, an LED light source from a UE device may be used). In the example, the analyte sensor system 308 is the applicator or the analyte sensor system 30 When removed from the packing of the detector, the sticker or other element covering the detector automatically Once removed, exposure may be performed.

[0222] The operation detection circuit 520 and / or operation detection component 545 are lower power state Conductivity which may be used to trigger the analyzer sensor system 308 to terminate the state This may include a base sensor. Such a sensor is deployed when the analyte sensor system 308 is deployed. The resistance measured through the user's skin when applied can be utilized, for example, conductivity-based resistance. The sensor is deployed as the analyte sensor system 308 is deployed and the analyte sensor 10 is embedded in the user. Before it gets mixed in, a large (e.g., open circuit) resistance can be measured. However, the analyte sensor Once system 308 is deployed and the analyte sensor 10 is embedded, the conductivity-based sensor The resistance measured by the conductive path through the user's skin may decrease. The path is between the two electrodes of the actuation detection circuit 520 and / or actuation detection component 545. This can be measured between the following points. For example, the first conductive probe is in contact with the surface of the user's skin during deployment. It is possible that the resistance from the first conductive probe to the electrode of the analyte sensor 10 will be measured. Therefore, the resistance measured during deployment is detectably lower than before deployment. Alternatively, In addition to this, two or more conductive probes are at a certain distance (for example, a few millimeters). There is a possibility of contact with the user's skin surface at different locations, between the probes before deployment. A lower resistance than the resistance measured by the analyte sensor system 308 is obtained after deployment. The resistance measured between these (for example, two) conductive probes before and after deployment is The analyte sensor system 308 uses the change to terminate the lower power state. It is possible.

[0223] In some cases, one or more electromechanical or mechanical switches or sensors are made It can be used for dynamic purposes. In this embodiment, the actuation detection component 545 is a switchable Includes sensors. For example, a mechanical switch may be located on the analyte sensor system 308. The switch allows the outer and inner parts of the analyte sensor system 308 to be separated from each other. It can be sealed (for example, using a gasket). Switch-type sensors are A mental switch or a latching switch can be used, and the circuit wake up To trigger the function (for example, by forming a connection via the wake-up pin) (e.g., power the circuit of the analyte sensor system 308) It can be used to connect to the battery. The switch is analyzed by the applicator during deployment. By unpacking / opening the object sensor system 308 and / or the analyte sensor... This can be triggered when stem 308 collides with / affects the user during deployment. The switch may be mechanically triggered when the analyte sensor system 308 is deployed. And may be released.

[0224] In this embodiment, the operation detection circuit 520 and / or operation detection component 545 are Used to cause the analyte sensor system 308 to terminate a lower power state. It may include two or more exposed contacts that are configured as open circuits. For example, an analyte sensor system The external electrical contacts of the Tem 308 are part of an open circuit inside the analyte sensor system 308. This is possible. Electrical contacts form an electrical connection with each other (for example, by using another conductive material). (to form a bridge) two such electrical contacts (for example, an electrical junction) By bridging (using the P), the operation of the analyte sensor system 308 is triggered. It is possible that two such electrical contacts are already electrically connected to each other. However, the act of disconnecting this connection may trigger the operation of the analyte sensor system 308. Alternatively, the nodes can be bridged or unbridged / disconnected by bridging or not bridging / disconnecting electrical contacts. Pull up or down to trigger the activation of the analyte sensor system 308, and / or A connection to the battery of the analyte sensor system 308 can be formed as a means of triggering the operation. An embodiment of this is further described with reference to Figure 6C.

[0225] The aforementioned bridge activates when the analyte sensor system 308 leaves the applicator. A bridge may be used to rig (for example, if the bridge is broken or formed The analyte sensor may be located within the applicator of the analyte sensor system 308, or in order to obtain the analyte. It may be part of the precurator. The bridge is the base plate of the analyte sensor system 308. It can be positioned to trigger operation during the assembly of the analyte sensor system 308. It can be used for (for example, a bridge may be broken or formed). For example, During the assembly of the previously connected analyte sensor system 308, two mechanically separated / Connectable pieces can be joined by the user or applicator, and this joining is It can form or destroy a block, which can trigger an action.

[0226] Using the bridge described above, (for example, from the battery of the analyte sensor system 308) To connect the power supply, or (for example, using the wake-up pin) to wake the circuit Up can be triggered. Using the bridge, the analyte is pre-connected via the retraction of the needle. The automatic wake-up of the sensor system 308 can be facilitated, and the needle has two conductive layers. A multilayer gasket with an insulating layer in the center is used to separate two sets of contacts on a circuit board. It functions as a bridge (jumper, etc.). While the needle is bridging the gasket, it rotates The paths can be bridged / closed. And (for example, of the analyte sensor system 308) (During deployment) When the needle retracts, the circuit is broken / opened / unbridged, triggering the operation. It is possible. One advantage of using a gasket through the needle path is that the analyte sensor system This involves reducing the size of the opening through the assembly of M308, which prevents the intrusion of debris and the user. This could help address potential concerns regarding the visibility of blood to debris and excess moisture. This can help prevent blood from reaching the wound site and conceal the blood from the user.

[0227] Figure 6A shows the skin sensor analyte of the analyte sensor system 308 according to an embodiment of the present disclosure. This shows the applicator 7100 for the Nburi. Applicator 7100 is the same as applicator 710 Displaced on the side of 0, for example, on the side of the outer housing 7101 of the applicator 7100 It may include a modified actuation element 7104. In some embodiments, the actuation element 7104 is a button Switches, toggles, slides, triggers, knobs, rotating members, deformation and / or bending Insertion of a portion of the applicator 7100, or the analyte sensor 530 and / or Any other suitable mechanism for operating the retraction assembly of applicator 7100 is Obtain. In some embodiments, the actuating element 7104 is positioned at any position, for example, the application. The application may be positioned on the top, upper, lower, or any other location of the TA7100. The TA7100 is held by the host in their hand, for example with their thumb, or their index finger and / or middle finger. It may be large enough to press the actuation element 7104 or to actuate it in any other way. The applicator 7100 is used with the analyte sensor system 308, as well as the aforementioned operation detection. Sized appropriately to accommodate one or more components of Component 545 It is possible.

[0228] The applicator 7100 may be configured to have one or more safety features, and the safety features The applicator 7100 can be prevented from operating until it is deactivated. In one embodiment, one or more safety functions are provided by the applicator 7100. The applicator 7100 will not activate unless it is pressed against the host's skin with sufficient force. Furthermore, the applicator 7100 translates beyond a predetermined static distal position. Rather than based on the components above, it presses against the host's skin with a force exceeding a predetermined threshold. Based at least partially on one or more components, one or more components The toe may be further configured to retract internally. In other words, the applicator 71 00 implements force-based retraction triggers, rather than being limited to displacement-based retraction triggers. You may do so.

[0229] Figure 6B shows an exploded perspective view of the applicator 7100 of Figure 6A, according to several embodiments. As shown, the applicator 7100 may include an outer element 7104. The applicator housing 7101 may include the outer applicator housing 7101. The force applied to the applicator 7100, especially the inner housing 7102, by the strike It then translates distally, causing the applicator 7100 to fire the actuator element 7104. It may be configured to align to a position where it is possible.

[0230] The applicator 7100 connects the analyte sensor assembly 360 (for example, as shown in Figure 3A) (as referenced above) at least one or more used for application to the host's skin It may further include an internal housing 7102 configured to house the mechanism. As described above, the analyte sensor assembly 360 controls the analyte sensor system 308. May include or accommodate. Distal surface 7130 of the bottom opening of the inner housing 7102 This can define the bottom surface of the applicator 7100. In some embodiments, the applicator When 7100 is pressed against the host's skin, the skin becomes substantially convex at the distal surface 7130. It can be deformed. A small portion of the skin surface is located at the bottom opening of the applicator housing 7102. At least a portion of it extends in the proximal direction beyond the plane defined by the distal surface 7130, inside It extends within the bottom opening of the housing 7102. The aforementioned operation detection component 545 One or more components may be, for example, an NFC component, a magnet, or an analyte. Any other component of the above that may be outside the sensor system 308 In some embodiments, this may be contained within or on the internal enclosure 7102. The barrier layer 7194 may be positioned above the bottom opening of the inner housing 7102. .

[0231] The applicator 7100 operates when the actuating element 7104 opens the inner housing 7102. Until 7106 is aligned, the outer housing distal to the inner housing 7102 The host presses the applicator 7100 against the skin with enough force to translate the G7101. This may include the following. Once such positional alignment is achieved, the host moves the actuator 7104 It can be started (for example, by pressing). In some other embodiments, the applicator 7 100 may be actuated first by the actuating element 7104, but the outer housing 7101 is internal Actual insertion is triggered until the side housing 7102 is sufficiently translated distally. It may be configured so as not to. In yet another embodiment, the actuation element 7104 is connected to the host Therefore, the applicator 7100 does not need to explicitly activate the actuation element 7104. The actuation element 7104 may be biased toward the center, but instead, the actuation element 7104 is directed toward the outer housing 7 When 101 is sufficiently translated distally to the inner housing 7102, it automatically inserts. It may be configured to start.

[0232] As an example, Figure 6C shows a bry that may be used in connection with the operation of the analyte sensor system 308. Figure 6C shows a slider-based sensor or switch. The first contact 604 and the second contact Analyte sensor electronic module 6 which can be connected to analyte sensor 602 using point 606 The part labeled 00 is illustrated. For example, the analyte sensor electronic module 600 is an analyte sensor The 602 can be connected to the analyte sensor 602 before it is implanted in the user. The electronic module 600 electrically connects the first contact 604 and the second contact 606 to each other. It may be configured to form a bridge during the deployment / application of the analyte sensor system 308. It may include a conductive bridge 612 (e.g., a jumper). The conductive jumper 612 is divided It is at least partially located between the two electrical connections of the precipitate sensor system 308 Yes, it is possible. The conductive jumper 612 is connected to two springs 6 by a conductive link 616. It may include 08, conductive jumper 612 and spring 608, analyte sensor system Supported by housing 614 of M308. Development of analyte sensor system 308 When open / applied, the springs 608 are electrically connected to each other through physical contact. It flexes, and is therefore used to trigger the operation of the analyte sensor system 308. It is possible to form a bridge.

[0233] Referring again to Figure 5, and as an example to Figure 6C, the operation detection circuit 520 and / or In various embodiments, the operation detection component 545 terminates a lower power state. Non-conductive separation tab type which can be used to cause the analyte sensor system 308 to perform this action. This may include a sensor or switch. For example, a non-conductive material is placed between spring-loaded electrical contacts. It is possible. Next, by removing the non-conductive material, the spring-loaded electrical contacts can be physically / electrically connected. The contacts can be formed and electrically coupled. Using these spring-loaded electrical contacts, ( For example, connect the power supply (from the battery of the analyte sensor system 308) and / or (example) For example, as a wake-up pin, it triggers circuit wake-up and lowers the power state. The analyte sensor system 308 can be instructed to terminate the process.

[0234] In this embodiment, the operation detection circuit 520 and / or operation detection component 545 are Used to cause the analyte sensor system 308 to exit a lower power mode. This may include strain / force-based sensors. Housing of Analytical Sensor System 308 / Detects strain (e.g., total deformation divided by the initial dimensions of the main body) or force placed on the main body. One or more sensors that may be capable of performing this may be included in the analyte sensor system 308. Such strain or force can, for example, affect the app gripping the analyte sensor system 308. It can be added by a caterer. In some examples, strain gauges are used in analyte sensor systems. It can be used inside the housing of the 308, where the strain gauge is, for example, in a printed circuit. It can be electrically coupled to the operation detection circuit 520 via wiring on the circuit board, etc. The bridge may be located on or connected to the Wheatstone Bridge. It can be combined. Strain gauges can monitor the resistance using a Wheatstone bridge. The resistance value can be varied. Various types of strain gauge configurations are associated with the Wheatstone bridge. A quarter can be used, for example, depending on the orientation of the strain gauge and the type of strain to be measured. -Bridge, half-bridge, and full-bridge may be used. Strain / force measurement is also used for analysis. Acceleration force during deployment of the object sensor system 308, and / or analysis of the object sensor on the user's body. It can be used to detect instantaneous effects such as shocks on the system 308. For example, strain. The force measurement is used to bring about triggers 906 and / or 910, as shown in Figure 9. It can be used.

[0235] In certain embodiments, the operation detection circuit 520 and / or operation detection component 54 5, in particular, triggers the operation of the analyte sensor system 308 without user intervention. To create detectable events that can be used for this purpose, the analyte sensor system 308 It may include additional components that can be added internally or externally. For example, the purpose of operation The current generation component can then be used in conjunction with the analyte sensor system 308. For example, a magnetic element can be magnetized or added to an applicator needle or needle hub. It may be used for operational purposes. When the analyte sensor system 308 is deployed, a magnetic needle or The auxiliary magnetic rod can be retracted relative to the analyte sensor system 308. The motion detection component 545, for example, around the analyte sensor system 308, provides electromagnetic response An induction coil can be used to generate an electric current (e.g., or other electrical signals) via it. Or it may include an NFC antenna. Applicator for drawing out a needle, rod, or other magnetic element. The movement creates relative motion between it and the coil / antenna of the analyte sensor system 308. This can be done. Next, this current or other electrical signal is used to perform analyte sensing. The operation of the TEM308 can be triggered. In some cases, the analyte sensor system M308 may already include an NFC antenna, and therefore this function is analyzed. It is not necessary to add any components to the sensor system 308.

[0236] In another example, piezoelectric components can be used, and piezoelectric components can be analyzed. The object sensor system 308 generates a voltage in response to forces (e.g., impact forces) that may occur during its deployment. For example, water is used to supply water to the operation detection circuit 520 and / or operation detection component 545. A crystal oscillator may be included, and when the analyte sensor system 308 is subjected to an impact based on deployment, The voltage generated by the crystal spikes or increases, ending the lower power state. The analyzer sensor system 308 is triggered.

[0237] User-based input-based termination of lower power states. In certain embodiments, a switch / sensor / mechanism / method is used to detect a user step. And using it, the operation of the analyte sensor system 308, either alone or in accordance with this specification It can be triggered in combination with other described operation detection methods / means. The touch / sensor / mechanism / method can usually depend on user intervention / actions. In this example, the detection switch / element / sensor is located on the analyte sensor system 308. It can also be used to trigger an operation or to terminate a lower power state. Example As such, at least a portion of the operation detection component 545 is the analyte sensor system 30 Externally, such as a removable sticker on the surface of 8, the analyte sensor system 308 It may include detection elements / components that allow the user to peel off / remove the sticker. In response, the analyte sensor system 308 may be triggered to exit a lower power state. As another example, the detection element is associated with the feeding of the analyte sensor system 308. This could be a feature of the precautor, packaging, box, or tray. Here, for example... See Figures 6A and 6B. In some cases, the detection element is an analyte sensor. It could be a component located in the packaging near the stem 308.

[0238] The detection element may include a conductive material (e.g., metal, graphite, etc.), and in the embodiment... This includes sensors (for example, capacitive, inductive magnetic, RF, and as described herein). (It uses other types of detection), but if the detection element is removed by the user, the conductive material The removal of the substance can be detected. In certain embodiments, the detection element is the analyte sensor system 308 A tag device (e.g., an RFID sticker) may be placed on the surface during its manufacturing / assembly. - may include etc. Next, the reader (e.g., NFC, RFID, etc.) removes the tag. It can detect and trigger an action. For example, when a tag device is in a predetermined position, the pinmeter The message may be replaced, but if the tag device is removed, the replacement will not occur and the operation will stop. It is possible.

[0239] In some cases, removing the detection element exposes the light sensor, causing it to malfunction. The detection element may be optically opaque so that it can be easily detected. For example, a light sensor is optically opaque. The sensor can be exposed by peeling off the sticker to expose it. Alternatively, the detection element may be optically colored (for example, green or another color). However Therefore, such removal of the detection element results in a wavelength shift that can be detected using an optical sensor. This can result in a change in color. For example, a color shift can occur, such as changing from green to white, and the color change can be used. This can trigger the operation.

[0240] The specific electromechanical detection method described above activates the target or analyte sensor system 308. It may be used in relation to embodiments that utilize user steps in order to do so. For example, the user , such as pressing a button, pulling a tab, or performing steps to form or break a bridge This can trigger the operation of the analyte sensor system 308. The user embeds the analyte sensor 10. Instructions should be given to perform these steps before or after the installation, or within a specific time frame. It is possible.

[0241] In this embodiment, the signal is from an external device or a signal generated based on user input. The operation of the analyte sensor system 308 can be triggered using an electronic device. (For example, see Figure 1, a smartphone, a proprietary analyzer display device, or a smartphone) Using the display of a smartwatch, (for example, as mentioned above, the device's flat screen) Light, sound (e.g., frequency), or vibration (from a shoo or screen) are detected by the analyzer sensor. It can be directed to the system 308. Next, the operation detection circuit 520 and / or The operation detection component 545 is used for, for example, a photodiode, a microphone , or detect such external stimuli via a piezoelectric sensor and operate in response to them It can be triggered. For example, the user can use a microphone and / or accelerometer. On the analyte sensor 308, which is detected using and can be used to trigger an action. The pattern can be tapped. The accelerometer of the analyte sensor system 308 is also the purpose of operation. For example, human gait / walking pattern detection can be used. That is, analysis If the object sensor system 308 detects that a person is moving according to a human gait, It can be inferred that the analyte sensor 530 was embedded.

[0242] Each of the above methods terminates the lower power state of the analyte sensor system 308 It may be used alone or in combination with any of the other methods described above for the purpose of performing the action. Please understand that the methods used (singular or plural) include, for example, power System design including considerations regarding consumption, weight, size, and level of user interactivity. It may depend on the factors considered in the calculation.

[0243] Use of state machines to terminate lower power states One or more embodiments disclosed herein are analyte sensors (e.g., the analyte sensor shown in Figure 5). This utilizes impedance measurement and / or current counting to indicate the current flowing through the impedance (530). And when the analyte sensor is deployed within the host's skin, therefore the sensor electronic circuit At least a portion (for example, the analyte sensor system 30 in Figure 5, not limited to) 8) Ends lower power "storage" or "sleep" mode and "wake-up" To complete, process one or more samples of the sensor signal and / or sensor data. It is possible to determine when to begin. In addition to this, or instead, such analytes The sensor electronic device of sensor system 308 switches to powered "execution" mode, and analyzes the sample. Calibrate or recalibrate the Sensor 530 periodically or randomly, and / or the analyte sensor. When monitoring the sensitivity of the 530, current count and / or impedance measurements such as However, it can be used.

[0244] Some embodiments are clock processor type controllers (for example, the processor in Figure 5) Using the sass / microcontroller 535, one or more terminals of the analyte sensor 530 are connected. The pulse voltage is provided above, and the continuous current of the analyte sensor 530 is determined based on the response to the pulse voltage. Perform impedance and / or current count and / or impedance measurements or determinations. Alternatively, impedance measurements can be averaged and analyzed. Such pulsed voltages The average current and / or the average current flowing through the analyte sensor 530 may have a duration on the order of milliseconds. Alternatively, an accurate estimation of the impedance of the analyte sensor 530 can be performed over a long period (e.g., 10-10 This requires many current count samples (e.g., 125) to be averaged over 2 seconds. It is possible. Although such controller-based solutions are illustrated to work, the sample During the data acquisition process, the clock processor-type controller 535 is not constantly supplied with power. ...which requires a significant amount of power, and the onboard battery does not have sufficient capacity to handle the load. However, it may not be sustainable.

[0245] One solution is described in more detail below, at least in relation to Figures 12-15. The system measures and / or determines a current count indicating the current flowing through the analyte sensor 530. Such controller-based methods for hardware-based state machines (for example, Figure 14) The condition machine (1430) is offloaded, and the hardware-type condition machine is cloaking It consumes considerably less power than the processor-based controller 535. In the solution, the clock processor-type controller 535 controls one or more of the state machines 1430. Set the parameters, and then the controller 535 itself will keep the battery "awake". Rather than performing all actions by unnecessarily consuming power, It transitions to a "sleep" state. In some embodiments, the state machine 1430 has one or more states. The registers (for example, parameter register 1436 in Figure 14), one or more counters (e.g. For example, counter 1434 in Figure 14, and / or one or more memories (for example, in Figure 5) This can be implemented using a portion of the storage device 515.

[0246] While the controller 535 is in a lower power "sleep" state, the state machine 1430 is Controls the application of one or more pulse voltages between the terminals of the analyte sensor 530, and one or more pulses The measurement of the current induced in the analyte sensor 530 by voltage is controlled, and the response of the current is controlled. The task is to store one or more data samples (e.g., digital counts) based on this. It is possible to do so. Next, the controller 535 receives an interrupt from the state machine 1430 or It wakes up in response to a wake signal, and its number is variable depending on the specific implementation. One or more stored data samples can be obtained and processed. Such a solution is clock Compared to the above data acquisition process that uses only the processor-based controller 535, The overall power consumption of the precipitate sensor system 308 was reduced by 50-60% or more in some cases. It can be reduced.

[0247] Using the status machine 1430, the controller is in a "storage" mode where it is mostly in "sleep" mode. Between or consecutive analytes (e.g., glucose), the measured values ​​are measured, determined, estimated, and During "run" mode when being processed by / or other means, the analyte sensor flows through Capture, at least partially process, and / or record the current count corresponding to the current. It is possible to remember.

[0248] During this "storage" mode, the analog front end (A) of the analyte sensor system FE) (for example, at least a portion of the sensor measurement circuit 525 in Figure 5) periodically (for example) (It wakes up every 64 seconds) and switches between "storage" mode and "run" mode or "wake" mode. The analyte sensor 530 is inserted into the host's skin to indicate that the transition to the state is appropriate. To determine whether or not it is present, one or more current indicators showing the current flowing through the analyzer sensor 530 are used. A tum measurement can be performed. Using this process, the analyte sensor 530 can detect skin The current count value indicates that the sensor is inserted correctly, but if the sensor is inserted incorrectly into the host's skin... The analyte sensor 530 is exposed to environmental conditions that may indicate this (e.g., high relative humidity). It can also be distinguished from the current count value that indicates presence. Therefore, this process is as follows: As detailed therein, for example, the controller 535 malfunctions under high relative humidity conditions. This can help avoid quacking. For example, the analyte sensor 530 can detect the host skin. When inserted into the skin, the analyte sensor 530 exhibits a relatively moderate to low impedance (e.g., For example, a specific observed current flow through the analyte sensor 530 (hundreds of kΩ) results in This will result in the analyte being... However, if the relative humidity is sufficiently high (for example, >90%), If the sensor 530 is not inserted into the host's skin, the analyte sensor 530 has a relatively high but The impedance of the non-open circuit (e.g., 1.6 MΩ) 530 is used by the analyte sensor 530. This results in different observed current flows, and the higher the relative humidity, The observed current flow through the analyte sensor 530 increases (see, for example, Figure 7C). The state machine 1430 described herein enables the distinction between these two states. Furthermore, these environmental conditions (e.g., sufficiently high relative humidity) may cause the controller 535 to malfunction. This prevents false wake-ups from being triggered, thereby eliminating the need for controller 535. This further reduces power consumption caused by unnecessary and inappropriate wake-ups.

[0249] Figure 12 shows the current flowing through the analyte sensor 530 in at least one embodiment. For example, regarding the state machine 1430 in Figure 14, to determine one or more current counts indicating The following is a sequence of state diagrams 1200. The state diagram 1200 shows five potential delay states (for example, delayed Delay 1WE_L state 1206, Delay 2WE_L state 1212, Delay 1WE_H state 1216 , delay 2WE_H state 1224, and idle state 1228) and two potential states Sampling state (for example, pre-count sampling state 1208 and pulse count state) It shows seven potential states, known as the pumping state (1220). Operation of state machine 1430. This will be described in more detail below in relation to Figures 13-15, but a brief overview is provided here. This can help in understanding the functions and usefulness of different states.

[0250] To finally determine the impedance of the analyte sensor 530, a known voltage is used to determine the analyte. A voltage may be applied between the terminals of sensor 530, and using Ohm's law, its known voltage The impedance can be determined based on the generated current. However, the voltage is not known. The current generated by this does not necessarily correspond to the membrane impedance of the analyte sensor 530, for example. It may have components that are not directly caused by other environmental factors. Based on a single current or current count measured in response to the application of a known voltage between sensor terminals. The impedance determined thereafter is the actual membrane impedance of the analyte sensor 530. It may not accurately reflect the state of the analyte sensor system 308, for example. To change from "Sleep" or "Storage" state to "Wake" or "Run" state It may not be a reliable indicator. Therefore, when making a determination of such a change in state... Therefore, it may be desirable to use multiple current or current count measurements.

[0251] Therefore, while the working electrode of the analyte sensor 530 is held at the first potential... A first current count value can be determined. This first current count is a baseline value. It can be considered that... Next, the working electrode of the analyte sensor 530 is set to a higher potential than the first potential. It can be held in a second potential, and the second current count value can be determined. The second current count value can be considered as a pulse value. The first current count value and the second current If the interval between the count value and the measurement is sufficiently small, the first current is obtained from the second current count value. By subtracting the count value, we can reliably remove the influence of environmental factors from the measurement. This is possible, and at such a sufficiently small interval between measurements, the influence of such environmental factors is 1 It can be assumed that the effect is similar to that on both the first current count and the second current count. Therefore, with this impedance, the first current count and the second current count Based on the understanding that it is inversely proportional to the difference, the precise film size of the analyte sensor 530 is determined from there. The impedance value can be obtained.

[0252] However, the first potential and the second potential are between the terminals of the analyte sensor 530. When applied, the initial instantaneous current induced via the analyte sensor 530 is, for example, shown in Figure 7. As mentioned above in relation to A, the RC characteristics of the analyte sensor 530 follow Ohm's law. It does not show the steady-state impedance of the sensor, which is determined by this. Therefore, 1 By implementing delay states 1206, 1212, 1216, and 1224, Sun During the pulling states 1208 and 1220, the current count measured by the analyzer sensor 530 It can be ensured that the initial dynamics of the RC characteristics are not substantially affected.

[0253] As shown in Figure 12, states 1206, 1208, 1212, 1216, 1220, The order of 1224 and 1228 is always the same, but the pre-count sampling state 12 All states except 08 are pre-configured by the controller 535 in the state machine 1430. (See Figure 14) and / or associated parameter register 1436 (See Figure 14) It can be bypassed according to the reference. Each state in Figure 12 also has a pre-configured duration. It can have. A counter (for example, counter 1434 in Figure 14) is configurable. The countervalue is continuously counted between each valid state until it is reached, and the change to the next valid state is... Reset counter 1434 to time the next valid state, and trigger the next valid state. This is possible. In some embodiments, this process is performed by a single counter 1430 in the state machine This enables timing of all valid states of the instrument 1430, thereby allowing the analysis sensor to be measured. Simplify system design and reduce associated manufacturing costs.

[0254] The state diagram 1200 starts from the start block 1202, proceeds to block 1204, and then the first Determine whether delay state 1206 (e.g., delay 1WE_L) is valid. If the delay state 1206 is invalid, the state diagram 1200 will proceed directly from block 1204. Proceed to sampling state 1208. If the first delay state 1206 is enabled, state Figure 1200 shows the transition to the first delay state 1206, which is configurable. The duration can be, for example, approximately 1-2 milliseconds or any other suitable duration. At the start of the first delay state 1206, the state machine 1430 controls the operation of the analyzer sensor 530. Apply a first potential to the working electrode, or apply a first potential to the working electrode of the analyte sensor 530. The application of the signal can be controlled. During the first delay state 1206, at least as shown in Figure 14. As such, by the state machine 1430 and / or support hardware or There are no current count measurements captured by the software.

[0255] When the first delay state 1206 expires, the state diagram 1200 returns to the first sampling state 1 Proceed to 208, during which time the first voltage is maintained at the working electrode of the analyte sensor 530, and the first One or more samples (e.g.,) corresponding to the current induced in the analyte sensor 530 by the potential. For example, the digital count is at least as shown in Figure 14, state machine 1430 and / or captured and / or processed by supporting hardware or software The first sampling state 1208 is configured for a configurable period depending on the application, for example. It can last for approximately 2 to 300 seconds.

[0256] When the first sampling state 1208 is completed, state diagram 1200 will show block 1210 Proceed to determine whether the second delay state 1212 (e.g., delay 2 WE_L) is valid. Determine. If the second delay state 1212 is invalid, the state diagram 1200 is block 12 Proceed directly from 10 to block 1214. If the second delayed state 1212 is enabled, state Figure 1200 shows the transition to a second delay state 1212, where the second delay state 1212 is configurable. The duration can be, for example, approximately 1-2 milliseconds or any other suitable period. The state machine 1430 operates the analyzer sensor 530 during the duration of the second delayed state 1212. It is possible to maintain a first potential at the electrode or to control the maintenance of the first potential. During the second delay state 1212, the state machine 14 is at least as shown in Figure 14. Captured by 30, and / or by supporting hardware or software There are no current count measurements available.

[0257] When the second sampling state 1212 is completed, state diagram 1200 will show block 1214 The process then proceeds to determine whether the third delay state 1216 (for example, delay 1WE_H) is valid. Determined. If the third delay state 1216 is invalid, the state diagram 1200 is block 121 Proceed directly from 4 to block 1218. If the third delay state 1216 is enabled, state diagram 1200 proceeds to a third delayed state 1216, and the third delayed state 1216 is configurable The duration can be, for example, approximately 1-2 milliseconds or any other preferred duration. At the start of the third delayed state 1216, the state machine 1430 is at a second potential higher than the first potential. The potential is applied to the working electrode of the analyte sensor 530, or the application of the second potential is controlled. This is possible. Due to the RC characteristics of the analyte sensor 530, the initial sample passing through the analyte sensor 530 The current flow occurs during the third delay state 1216 and can be substantially attenuated. During the third delay state 1216, the state machine 143 is at least as shown in Figure 14. Captured by 0, and / or by supporting hardware or software. There are no current count measurements available.

[0258] When the third delay state 1216 expires, the state diagram 1200 proceeds to block 1218. Determine whether the second sampling state 1220 is valid. If state 1220 is invalid, state diagram 1200 will proceed directly from block 1218 to block Proceed to 1222. If the second sampling state 1220 is active, state diagram 1200 is Then, the process proceeds to the second sampling state 1220, during which the second voltage is measured by the analyte sensor 530. Maintained by the working electrode, and corresponding to the current induced in the analyte sensor 530 by the second potential. One or more samples (e.g., digital counts) related to Figures 13-15 As described in more detail below, the condition is captured and / or processed by machine 1430. The second sampling state 1220 can be configured for a period of time, for example, about 3, depending on the application. It can last for up to 4 seconds.

[0259] When the second sampling state 1220 is completed, state diagram 1200 will show block 1222 Proceed to determine whether the fourth delay state 1224 (for example, delay 2WE_H) is valid. Determined. If the fourth delay state 1224 is invalid, the state diagram 1200 is block 122 Proceed directly from 2 to block 1226. If the fourth delay state 1224 is enabled, state diagram 1200 proceeds to the fourth delayed state 1224, and the fourth delayed state 1224 is configurable The duration can be, for example, approximately 1-2 milliseconds or any other suitable duration. The state machine 1430, during the duration of the fourth delay state 1224, the analyzer sensor 530 It is possible to maintain a second potential at the working electrode or to control the maintenance of the second potential. During the fourth delay state 1224, the state machine 1 is at least as shown in Figure 14. Captured by 430 and / or by supporting hardware or software There are no current count measurements available.

[0260] When the fourth delay state 1224 expires, the state diagram 1200 proceeds to block 1226. Determine whether a fifth delay state 1228 (e.g., extended idle state) is active. If the fifth delay state 1226 is invalid, the state diagram 1200 will be from block 1226. Returning directly to block 1204, state machine 1430 executes the entire state diagram 1200 again. If the fifth delay state 1228 is active, the state diagram 1200 shows the fifth delay state 122 Moving on to 8, the fifth delay state 1228 has a configurable duration, e.g., approximately 1 millisecond to 64 milliseconds. It can last for seconds or any other preferred duration. Fifth delay state 1228 At the start, the state machine 1430 reapplies a first potential to the working electrode of the analyte sensor 530. The analyte sensor 53 can either control the reapplication of the first potential to the working electrode, or control the reapplication of the first potential to the working electrode. It is possible to provide 0V to the working electrode or to control the provision of 0V to the working electrode. or (for example, by opening the switch of the circuit including the analyte sensor 530) analysis To provide an open-circuit voltage (e.g., a high Z state) to the working electrode of the object sensor 530, or to act The provision of an open-circuit voltage to the electrodes can be controlled. This potential corresponds to the fifth delayed state 122 It can be maintained at the working electrode for a duration of 8. During the fifth delayed state 1228, Even if not, as shown in Figure 14, the state machine 1430 and / or support There are no current count measurements captured by hardware or software.

[0261] In some embodiments, the analyte sensor 530 is not actively measuring analyte values. Activation of the fifth delayed state 1228 for the operation of the machine 1430 during storage mode. It can be reserved, during which time it is mainly defined by the duration of the fifth delay state 1228. The first sampling state 1208 and / occurs during a longer period of inactivity. Alternatively, samples may be collected only intermittently during the second sampling state 1220.

[0262] Furthermore, the first and second voltages mentioned above can be fully configurable, and several In this case, they may be able to be configured independently of each other. For example, the first voltage and the second voltage It can be programmed in approximately 16mV steps (for example, 64 steps) from 0V to 1V. In addition, the first voltage and the second voltage are obtained when the analyte sensor system 308 is currently, In either the analyte sensor 530 is in "storage" mode and is not inserted into the host's skin, or During this time, the analyte sensor 530 is inserted into the host's skin, and continuous and / or intermittent grading is performed. "Execution" mode in which a course measurement is taken, determined, and / or captured in other ways. Depending on where it is located, it can have different values. For example, in this "execution" mode. For example, the first voltage could be 0.6V, and the second voltage could be 0.616V (for example, the first voltage... While it can be up to 16mV higher, in this "storage" mode, the first voltage is 0 It can be V, and the second voltage is 0.016V (for example, 16mV greater than the first voltage). could be.

[0263] In some embodiments, the use of 0V for the first voltage during “storage” mode is min Applying a defined non-zero bias voltage between the terminals of the precipitate sensor 530 for an extended period of time can cause acid This could be advantageous as it could cause accelerated transformation and / or damage to the sensor 530. For the reasons stated above, during the fifth delay state 1228, an open-circuit voltage is applied to the working electrode of the analyte sensor 530. For example, applying a high Z state or 0V often results in a fifth delay state 1228. The potential for damage is applied between the terminals of the analyte sensor 530 during the extended duration. This helps ensure that there is no bias voltage, thereby the analyte sensor 53 Oxidation of 0 to the analyte sensor 530 during "storage" mode before deployment within the host skin. Alternatively, it can reduce other types of damage.

[0264] Furthermore, although examples of the duration of each state in the state diagram 1200 are shown above, this disclosure is In some embodiments, Figure 1 Counter 1434 of 4 may include configurable bit counters. For example, counter 14 34 has a maximum value of 1 second, and a first delay state 1206, a second delay state 1212, Third delay state 1216, second sampling state 1220, and fourth delay state 12 Each of the 24 intervals is measured in increments of approximately 976 microseconds (for example, 1 / 1024 of a second). It can be configured as a 10-bit counter that can be configured in some embodiments. The counter 1434 has a maximum value of 8.53 minutes, and the first sample state 1208 And when timing each of the delay states 1228, it takes approximately 976 microseconds (for example, 1 / 2 of a second). It can be configured as a 19-bit counter that can be constructed in increments of / 1024.

[0265] The operation of the analyte sensor system 308 is described in the timing shown in Figure 13, according to several embodiments. In conjunction with the functional block diagrams 1300 and 1400 in Figure 14, further considerations are given below. ru.

[0266] The timing diagram 1300 in Figure 13 relates to the state diagram 1200 in Figure 12, and the states described above. This shows the exemplary timing of several signals related to one or more of them.

[0267] Using the Pulse_Count_Ready signal 1310, the second sampling state During state 1220, the analog front end (AFE) analog-to-digital converter (AD) C) Analyte sensor 53 (for example, sensor measurement circuit 525) determined and integrated The current count corresponding to the current flowing through 0 is directed towards transmission to one or more modules in Figure 14. It can transmit a signal indicating that it is ready.

[0268] Using the Pre_Count_Ready signal 1320, the first sampling state 1 The analyte flowing through the AFE sensor 530 is determined and integrated by the ADC of the AFE over a period of 208. The current count corresponding to the current is ready for transmission to one or more modules in Figure 14. It is possible to transmit signals indicating that something has been accomplished.

[0269] Using the INT_Enable signal 1330, signals 1330 and 1332 and 133 Based on being high at 4, the first sampling state 1208 and the second sampling During one or both of the state 1220, the current flowing through the analyte sensor 530 corresponds to the current charge. The signal can be transmitted to the AFE's ADC by integrating the signal. Timing Diagram 1 300 is in state 1206, 1208, 1212, 1216, 1220, 1224, 1 During one or more of the 228, an exemplary working electrode potentiometer of the analyte sensor 530 is applied. This indicates Char 1340.

[0270] The block diagram 1400 in Figure 14 shows exemplary features of the state machine 1430, and, for example, less In relation to Figure 5, the sensor measurement circuit 525, the operation detection circuit 520, and / or at least some hardware expressions of the actuation detection component 545 and / or it shows the characteristics of a software expression.

[0271] For example, block diagram 1400 is, as previously mentioned in relation to Figure 12, for example, state machine 1 A parameter configured to store one or more parameters of one or more states of 430. A state machine 1430 that can include register 1436 is shown. For example, parameter register Sta 1436 indicates whether each potential state in state diagram 1200 is active and state Table of one or more configurable counter values ​​corresponding to the duration of each potential state in Figure 1200. It can store the indicated and. In some embodiments, parameter register 1436 One or more of the parameters indicate that controller 535 is in sleep mode or lower Before transitioning to power mode, it may be configured by the controller 535.

[0272] The state machine 1430 continues for each active state until it reaches a configurable counter value. It may further include a counter 1434 configured to count in this way. The configurable counter value can be defined by parameter register 1436. When counter 1434 reaches a configurable counter value, state machine 1430 proceeds to the next A state change signal 1438 can be triggered to advance to an active state. Counter 1 434 is reset based on reaching a configurable counter value for a specific state, It can be configured to start counting the timing for the next valid state. Thus, the counter 1434 receives a clock signal 1432 to adjust such counts. It can be trusted. In some embodiments, the clock signal 1432 is used for the AFE's AD It can be derived from the clock signal of C. For example, the ADC clock signal is, for example, It could be a 32kHz clock signal provided by a very accurate crystal. In this embodiment, this ADC clock signal is divided by 32 to obtain a frequency of 1,024 Hz. The clock signal 1432 can be obtained. H...

Claims

1. A system for monitoring analytes within a host, Analytical sample sensor electronic circuit, The analyte sensor is mechanically and electrically coupled to the analyte sensor electronic circuit before the analyte sensor is embedded in the host, An action detection circuit coupled to the analyte sensor and configured to generate an operable control signal to cause the analyte sensor to acquire information relating to the level of the analyte in the host, wherein the control signal is generated in response to an electrical signal indicating that a first condition is met, including a threshold indicating the embedding of the analyte sensor into the host, Includes, The system is configured such that the analyte sensor electronic circuit terminates a low power mode when the level of the analyte in the host satisfies a second condition, which includes the level of the analyte in the host exceeding another threshold, and the electrical signal indicates that the first condition is met.

2. An electrical signal indicating that the first condition is met is, The detected proximity between the analyte sensor electronic circuit and the reference object, The temperature monitored by the aforementioned analyte sensor electronic circuit, The output of the accelerometer of the aforementioned analyte sensor electronic circuit, A response generated using wireless signaling transmitted or received by the aforementioned analyte sensor electronic circuit, The change in atmospheric pressure detected by the aforementioned analyte sensor electronic circuit, The audio information monitored by the aforementioned analyte sensor electronic circuit, A signal generated by the analyte sensor electronic circuit in response to a photon detected by the analyte sensor electronic circuit, The conductivity measured between the two terminals of the aforementioned analyte sensor electronic circuit, A mechanical switch located on or inside the housing of the analyte sensor electronic circuit, A component configured to change the connection between two conductive elements of the analyte sensor electronic circuit in response to the movement of the component, The measured strain and, The system according to claim 1, which is generated using one or more of the following.

3. A system for monitoring analytes within a host, Analytical sample sensor electronic circuit, An analyte sensor configured such that the analyte sensor electronic circuit is coupled before the analyte sensor is embedded in the host, An operation detection circuit coupled to the analyte sensor and configured to monitor a secondary sensor according to the sampling frequency and to increase the sampling frequency in response to a first event detected using the secondary sensor, Includes, The operation detection circuit is further configured to monitor the secondary sensor according to the increased sampling frequency and to generate a control signal in response to detecting a second event, and when the analyte sensor is embedded in the host, the control signal is operable to cause the analyte sensor to measure in order to obtain information indicating the level of the analyte in the host. The system further comprises an analyte sensor electronic circuit configured to terminate a low power mode in response to the information indicating the level of the analyte in the host satisfying a condition, and in response to the operation detection circuit detecting the second event.

4. The system according to claim 1, wherein the control signal is a signal that causes a potentiostat to apply a voltage bias to the analyte sensor, thereby causing the analyte sensor to collect the information relating to the level of the analyte in the host.

5. A circuit for controlling the operation of an analyte sensor system, A detection circuit is configured to indicate whether a signal at the input terminal of the detection circuit satisfies a condition, and if the detection circuit indicates that the signal satisfies the condition, it is further configured to trigger the analyzer sensor system to terminate the lower power state. A first switch element configured to control the coupling between the input terminal of the detection circuit and the first terminal of the analyte sensor, wherein the analyte sensor is configured to collect information related to the analyte level in the host, A second switch element configured to control the coupling between the first terminal of the analyte sensor and the first terminal of the potentiostat, wherein the potentiostat is configured to apply a voltage bias to the analyte sensor to cause the analyte sensor to collect information related to the level of the analyte in the host, Includes, The input terminal of the detection circuit is connected to the second terminal of the analyte sensor and to the second terminal of the potentiostat. The circuit is configured to generate an additional detectable event to activate the analyte sensor system by, at a first time point, coupling the first terminal of the analyte sensor to the second switch element and the input terminal of the detection circuit to the first terminal of the analyte sensor and the first switch element; and at a second time point, disconnecting the first terminal of the analyte sensor to the second switch element and the input terminal of the detection circuit to the first terminal of the analyte sensor and the first switch element.

6. The circuit according to claim 5, further comprising a capacitive element coupled between the input terminal of the detection circuit and a second reference voltage.

7. The circuit according to claim 5, wherein the second switching element is configured to connect the input terminal of the detection circuit to the first terminal of the analyte sensor via a resistive element.

8. The circuit according to claim 6, further comprising a third switch element configured to couple the input terminal of the detection circuit to the second reference voltage.

9. The circuit according to claim 8, wherein the capacitive element discharges when the third switching element couples the input terminal of the detection circuit to the second reference voltage.

10. The circuit according to claim 9, wherein the terminals of the third switching element are coupled to a clock that periodically couples the input terminal of the detection circuit to the second reference voltage and the third switching element.

11. The circuit according to claim 5, wherein the first switching element is driven by a common signal, and the second switching element is driven by an inverted version of the common signal.

12. The circuit according to claim 5, wherein the first switch element and the second switch element are driven by a common signal and have opposite polarities.

13. The circuit according to claim 5, wherein when the analyte sensor is embedded in the host, the voltage at the input terminal of the detection circuit indicates the current between the first terminal and the second terminal of the analyte sensor.

14. The reference terminal of the detection circuit is coupled to a first reference voltage, and the detection circuit compares The circuit according to claim 5, including a device.

15. The circuit according to claim 6, wherein the second reference voltage is ground.

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