Medical devices

Abstract

To provide a medical device capable of maintaining an appropriate irradiation state to an affected area.SOLUTION: A medical device 10 for applying excitation light to a photosensitive substance accumulated in a tumor to destroy the tumor cell, comprises a light irradiation part 40 for applying the excitation light of the photosensitive substance, a body part 20 for holding the light irradiation part 40 so as to face a fixed direction, and a support part 30 extending from the body part 20 to a side where the light irradiation part 40 faces. The support part 30 includes a contact end face 32 on an opposite side of a body part 20, for keeping a distance between a light irradiation part 40 and an irradiation surface constant. Further, the medical device 10 comprises a space part S formed between the light irradiation part 40 and the irradiation surface P.SELECTED DRAWING: Figure 2

Description

Technical Field

[0001] The present invention relates to a medical device used for treating a lesion by irradiating light thereon.

Background Art

[0002] As local treatments for cancer, photodynamic therapy and photoimmunotherapy using a photoreactive substance having tumor cell selectivity are known (see, for example, Patent Document 1). Among these, a treatment method using a photosensitive substance (hydrophilic phthalocyanine) can specifically destroy target cells without destroying non-target cells such as normal cells by irradiating the photosensitive substance accumulated in a tumor with excitation light (for example, near-infrared light), and it is expected to obtain a high therapeutic effect while reducing side effects (see Patent Document 2).

Prior Art Documents

Patent Documents

[0003]

Patent Document 1

Patent Document 2

Summary of the Invention

Problems to be Solved by the Invention

[0004] When irradiating light on a lesion during treatment, the irradiation state of the light is closely related to the treatment range and the treatment effect. Therefore, in order to perform the treatment reliably, it is necessary to maintain an appropriate irradiation state of the light. However, in actual treatment, it is assumed that it may be difficult to maintain the state where the light is irradiated in an appropriate state for a certain period of time due to spatial constraints, constraints due to body posture, constraints on the irradiation range due to the light irradiation method, etc. For this reason, a technique or device capable of maintaining an appropriate light irradiation state is required.

[0005] This invention was made to solve the above-mentioned problems and aims to provide a medical device that can maintain an appropriate irradiation state for the lesion. [Means for solving the problem]

[0006] A medical device according to the present invention that achieves the above objective is a medical device that destroys tumor cells by irradiating a photosensitive substance accumulated in a tumor with excitation light, and comprises a light irradiation unit that irradiates the photosensitive substance with excitation light, a main body unit that holds the light irradiation unit so that it faces in a certain direction, and a support unit that extends from the main body unit toward the side toward the light irradiation unit, wherein the support unit has a contact end surface on the side opposite to the main body unit that maintains a constant distance between the light irradiation unit and the irradiation surface, and forms a space between the light irradiation unit and the irradiation surface. [Effects of the Invention]

[0007] In the medical device configured as described above, the contact end surface of the support part is brought into contact with the living body, thereby maintaining a constant distance and angle between the light irradiation part and the irradiation surface, and enabling stable irradiation of the lesion.

[0008] Furthermore, the support portion may be made translucent. This allows the irradiation state from the light irradiation area and the fluorescence of the lesion to be observed visually or through imaging devices such as an endoscope or surgical field camera.

[0009] Furthermore, the support portion may have an opening in a part of its circumferential direction, allowing the space to be directly viewed through the opening. This improves the visibility or observation of the irradiation state from the light irradiation portion and the fluorescence of the lesion. Moreover, it becomes possible to ensure visibility regardless of the material of the support portion.

[0010] Furthermore, the support portion may be formed such that its diameter expands from the main body toward the irradiation surface at an angle equivalent to the angle that the excitation light from the light irradiation portion makes with respect to the irradiation surface. This ensures that the space within the support portion is of sufficient size.

[0011] Furthermore, the main body may have an adjustment mechanism for adjusting and fixing the position of the light irradiation unit in the direction of the optical axis. This allows for appropriate adjustment of the optical axis position of the light irradiation unit. In addition, it is possible to adjust the range over which excitation light is irradiated when the contact end surface of the support unit comes into contact with a living body.

[0013] Furthermore, the support portion may have a marking portion that marks the biological surface in contact with the contact end surface. This allows the area treated with light irradiation to be visually identified, enabling efficient and reliable light irradiation.

[0014] Furthermore, the support portion may be formed in an expanding shape from the main body portion toward the irradiation surface, and a diameter-expanding adapter, which is continuous with the support portion and extends from the main body portion toward the irradiation surface, may be detachably attached to the contact end surface. This makes it possible to change the range to which the excitation light is irradiated, or to change the distance between the light irradiation portion and the irradiation surface, as needed.

[0015] Furthermore, the support portion may be formed from a self-expanding wire having a plurality of circumferential support wire portions extending from the main body portion toward the irradiation surface in an expanding diameter direction, and a tangent wire portion connecting the plurality of support wire portions at the end on the irradiation surface side. This allows the support portion to be housed in a storage sheath or the like to reduce its diameter and facilitate insertion into a living body.

[0016] Furthermore, the main body may be configured to hold a camera so as to be positioned alongside the light irradiation unit. This allows for direct observation of the irradiation state from the light irradiation unit and the fluorescence of the lesion. [Brief explanation of the drawing]

[0017] [Figure 1] It is a perspective view showing a medical device according to the first embodiment. [Figure 2] It is a cross-sectional view of the medical device. [Figure 3] It is a perspective view of the medical device when an opening is provided in the support portion. [Figure 4] It is an end view of the support portion according to the modified example. [Figure 5] It is a view of the holding portion seen from the bottom side when the camera is juxtaposed with the light irradiation portion. [Figure 6] It is a perspective view showing a medical device according to the second embodiment. [Figure 7] It is an enlarged perspective view of the vicinity of the support portion. [Figure 8] It is an enlarged cross-sectional view of the vicinity of the support portion. [Figure 9] It is an enlarged perspective view of the vicinity of the support portion when an opening is provided in the support portion. [Figure 10] It is an enlarged perspective view of the vicinity of the support portion and the applied marking when the support portion has a marking application portion. [Figure 11] It is an exploded perspective view of the diameter-expanding adapter and the support portion. [Figure 12] It is an enlarged perspective view of the vicinity of the support portion when the support portion is formed of a self-expanding wire. [Figure 13] It is a cross-sectional view showing a state where the support portion is housed in the housing sheath.

Mode for Carrying Out the Invention

[0018] Hereinafter, embodiments of the present invention will be described with reference to the drawings. Note that the dimensions in the drawings may be exaggerated for convenience of explanation and may be different from the actual dimensions. Also, in this specification and the drawings, components having substantially the same functional configuration are denoted by the same reference numerals, and redundant description is omitted. In this specification, the side of the device that contacts the living body is referred to as the "tip side", and the side that is operated is referred to as the "base end side".

[0019] The medical device 10 according to this embodiment is used for the treatment of tumors. The type of tumor is not particularly limited, but it can be applied to gynecological cancers such as endometrial cancer and ovarian cancer. The medical device 10 is used in photoimmunotherapy, which destroys target cells by irradiating a photosensitive substance accumulated on the cell membrane of target cells with near-infrared light, which is the excitation light for the photosensitive substance. Target cells are tumor cells such as cancer cells and cells of precancerous lesions. In this treatment method, a photosensitive substance is used as a drug, which is obtained by adsorbing an antibody that specifically binds only to a specific antigen on the surface of tumor cells and a photosensitive substance that is paired with that antibody. The antibody is not particularly limited, but examples include panitumubab, trastuzumab, HuJ591, pertuzumab, lapatinib, palbociclib, and olaparib. The photosensitive substance is, for example, a hydrophilic phthalocyanine, which is a substance that reacts to near-infrared light with a wavelength of approximately 700 nm (IR700), but is not limited to this. When IR700 is exposed to near-infrared light with a wavelength of approximately 660-740 nm, the ligand of the functional group that ensures its water solubility is cleaved, causing a structural change from water-soluble to hydrophobic. This structural change allows membrane proteins to be extracted, creating holes in the cell membrane and allowing water to enter the cell, thus rupturing and destroying tumor cells. In addition, IR700 is excited by near-infrared light and emits fluorescence at a wavelength different from the excitation wavelength. For example, when IR700 is excited by near-infrared light with a wavelength of 689 nm, it emits fluorescence at a wavelength of 704 nm. IR700 undergoes a structural change while emitting fluorescence through a photoreaction, and once it has destroyed tumor cells and fulfilled its role as a drug, it ceases to emit fluorescence.

[0020] The medical device 10 of the first embodiment is configured to be suitable for treatments that approach tumor cells via open surgery. As shown in Figures 1 and 2, the medical device 10 includes a light irradiation unit 40 that irradiates a photosensitive substance with excitation light, a main body 20 that holds the light irradiation unit 40 so that it faces in a certain direction, and a support unit 30 that extends from the main body 20 toward the side toward which the light irradiation unit 40 faces.

[0021] The light irradiation unit 40 has a long irradiation optical waveguide 41 and a light-emitting unit 42 located at the tip of the irradiation optical waveguide 41. The irradiation optical waveguide 41 is a long wire that propagates light. The irradiation optical waveguide 41 is formed by, for example, a single optical fiber. However, the irradiation optical waveguide 41 may be formed by multiple optical fibers. The base end of the irradiation optical waveguide 41 can be connected to an optical output device (not shown) that outputs light. The irradiation optical waveguide 41 can receive near-infrared light from the optical output device and propagate the near-infrared light to the light-emitting unit 42. The irradiation optical waveguide 41 is covered by a cable 43. However, the irradiation optical waveguide 41 may be formed by an optical waveguide other than an optical fiber.

[0022] The light-emitting unit 42 is a cylindrical diffuser connected to the end of the optical fiber, which amplifies the light received from the optical fiber with a uniform intensity distribution. The light-emitting unit 42 may be formed integrally with the optical fiber that forms the irradiation optical waveguide 41 by processing the surface or interior of the optical fiber. Alternatively, the light-emitting unit 42 may be the cut end of the optical fiber. The light-emitting unit 42 may be formed by a mirror and / or lens placed at the end of the optical fiber. The light-emitting unit 42 may be an LED or the like that emits light when powered. The light from the light-emitting unit 42 is emitted as diffused light with an angle α with respect to the irradiation surface P.

[0023] The main body 20 is the part that the operator grasps and has a gripping portion 22 with irregularities formed on its circumferential surface for easy gripping. A cable 43 is inserted through the main body 20 and a holding portion 24 for holding the light irradiation unit 40 is formed inside. The light irradiation unit 40 held by the holding portion 24 is exposed to the irradiation surface P and can irradiate the irradiation surface P with excitation light. The holding portion 24 has an adjustment mechanism 25 for adjusting and fixing the position of the light irradiation unit 40 in the direction of the optical axis. The adjustment mechanism 25 has a fastening portion 25a for tightening and fixing the light irradiation unit 40 and an adjustment screw 25b for adjusting the tightening state of the fastening portion 25a. When adjusting the position of the light irradiation unit 40, the adjustment screw 25b is loosened so that the fastening portion 25a does not restrain the light irradiation unit 40, and once the position of the light irradiation unit 40 is determined, the adjustment screw 25b is tightened to restrain the light irradiation unit 40 with the fastening portion 25a.

[0024] The adjustment mechanism may be a mechanism other than that of this embodiment. For example, instead of the adjustment screw 25b, an operating button may be provided so that the fixing of the light irradiation unit 40 by the fastening part 25a is loosened by operating the operating button. Alternatively, the outer surface of the light irradiation unit 40 or the inner surface of the holding part 24 may be formed of an elastically deformable material such as silicone rubber so that the light irradiation unit 40 can be fixed at a certain position in the optical axis direction.

[0025] The support portion 30 extends from the end of the main body portion 20 on the side facing the irradiation surface P toward the irradiation surface P. The support portion 30 has a substantially frustoconical shape that widens in diameter toward the irradiation surface P toward the main body portion 20, and has a contact end surface 32 on the opposite side of the main body portion 20 that maintains a constant distance between the light irradiation portion 40 and the irradiation surface P. The angle β that the support portion 30 makes with the irradiation surface P is set to be equal to the angle α that the excitation light from the light irradiation portion 42 makes with the irradiation surface P. When the contact end surface 32 contacts the surface of the living body, a space S is formed between the light irradiation portion 40 and the irradiation surface P that does not obstruct the excitation light. When the contact end surface 32 contacts the living body, the distance and angle between the light irradiation portion 40 and the irradiation surface P are kept constant, and uniform light with a constant intensity can be stably irradiated onto the irradiation surface P.

[0026] The support portion 30 is made of a translucent material such as glass or resin. This allows the surgeon to visually observe the irradiation state of the excitation light from the light irradiation portion 40 and the fluorescence emitted by the lesion, or to observe it through an imaging device such as an endoscope or surgical field camera (not shown). The endoscope includes flexible endoscopes and rigid endoscopes. Therefore, the surgeon can easily maintain and confirm the irradiation position of the excitation light from the light irradiation portion 40 by bringing the contact end surface 32 of the support portion 30 into contact with the living body and irradiating it with excitation light from the light irradiation portion 40. The medical device 10 of this embodiment is suitable for application to elevated lesions or invasive lesions exposed during laparotomy because the support portion 30 is brought into contact with the living body and excitation light is irradiated.

[0027] A contact detection unit 34 is provided at the lower end of the support unit 30 to detect the contact state of the contact end surface 32 with a living organism. The contact detection unit 34 can be composed of a sensor that detects the presence or absence of electrical resistance or conductivity at the contact end surface 32. The contact state of the contact end surface 32 detected by the contact detection unit 34 can be communicated to the operator by a notification unit (not shown) or the like.

[0028] The contact detection unit 34 may be a switch provided on the surface of the contact end face 32. In this case, the switch is turned on when the contact end face 32 comes into contact with a living body, and contact can be detected. Alternatively, the contact detection unit 34 may be a light-based sensor. In this case, light is guided to the light-transmitting support part 30, and the contact state can be detected by the change in reflected light at the contact end face 32. Or, the contact state may be detected by the change in ambient light incident from the contact end face 32 and propagating through the support part 30, which is attenuated due to contact. By providing the contact detection unit 34 on the support part 30, the operator can easily determine the contact state of the support part 30 with a living body, and more reliable irradiation of excitation light can be performed.

[0029] As shown in Figure 3, the support portion 30 may have an opening 36 in a part of its circumferential direction. Having an opening 36 in the support portion 30 allows the operator to directly observe the irradiation position of the excitation light without obstruction, or to observe it through an imaging device (not shown), thereby more reliably confirming the irradiation state and fluorescence from the lesion.

[0030] As shown in Figure 4, the cross-sectional shape of the support portion 30 may be made U-shaped to form the opening 37. This increases the width of the opening 37 and further improves the visibility of the illuminated surface P.

[0031] As shown in Figure 5, the main body 20 may be configured to hold the light irradiation unit 40 and the camera 47 side by side in the holding unit 24. By placing the camera 47 side by side with the light irradiation unit 40, the irradiation state of the excitation light can be confirmed and changes in fluorescence of the lesion can be detected.

[0032] Next, a treatment method using the medical device 10 according to the first embodiment will be described.

[0033] First, a photosensitive substance is administered into the body. The method of administering the photosensitive substance into the body is not particularly limited as long as the photosensitive substance can reach the tumor cells, but for example, it is administered intravascularly, and in this embodiment, it is administered intravenously. Approximately 12 to 36 hours after intravenous administration, the photoirradiation treatment is performed using the medical device 10 of this embodiment.

[0034] In this embodiment, the surgeon approaches the lesion by making an incision, as described above. The surgeon holds the main body 20 in their hand and brings the contact end surface 32 of the support part 30 into contact with the area around the lesion, positioning the light irradiation part 40 facing the lesion. By maintaining the support part 30 in contact with the living body, the distance between the lesion and the light irradiation part 40 can be kept constant. In this state, the surgeon operates the light output device to supply excitation light to the light irradiation part 40. This allows the light irradiation part 40 to irradiate the lesion with excitation light.

[0035] When excitation light is irradiated, it reaches photosensitive substances accumulated in tumor cells. This causes a chemical change in the photosensitive substances excited by the excitation light, and further structural changes in the photosensitive substances create holes in the cell membrane. As a result, the tumor cells irradiated with excitation light are destroyed.

[0036] The surgeon irradiates excitation light from the light irradiation unit 40 and observes the fluorescence emitted by the photosensitive substance excited by the excitation light, either visually or through an imaging device such as an endoscope or surgical field camera (not shown). The irradiation state of the excitation light and the fluorescence can be confirmed through the light-transmitting support unit 30. Alternatively, if the support unit 30 has openings 36 and 37, they can be visually observed through the openings 36 and 37. Furthermore, if the main unit 20 holds the camera 47, detection can also be performed using the camera 47.

[0037] The surgeon determines that sufficient destruction of tumor cells has been achieved in the area irradiated with excitation light when they determine that the fluorescence has disappeared by visual inspection or that a predetermined time has elapsed. If other tumor cells are present, the surgeon brings the contact end surface 32 of the support part 30 into contact with the surrounding area of ​​the other lesion and irradiates with excitation light.

[0038] Next, a second embodiment of the present invention will be described. The medical device 12 of this embodiment is configured to be suitable for treatments that approach tumor cells laparoscopically. As shown in Figure 6, the medical device 12 of this embodiment has a tubular portion 56 extending from a housing 50 and a main body portion 57 protruding from the tip of the tubular portion 56. The tip of the main body portion 57 is provided with a light irradiation portion 58 and a support portion 60. A rotation operation portion 55 is provided at the base of the tubular portion 56, allowing the main body portion 57 to be rotated about the axial direction.

[0039] The housing 50 includes a gripping section 52 for the operator to grasp, an in / out operation section 53 for the operator to operate the protruding state from the tubular section 56 of the main body 57, and an irradiation operation section 54 for the operator to operate the emission of excitation light from the light irradiation section 58.

[0040] By operating the irradiation control unit 54, the light irradiation unit 58 receives excitation light from the light output unit (not shown) inside the housing 50, and the light irradiation unit 58 can emit the excitation light as divergent light along the axial direction of the main body 57. The light output unit may be located outside the housing.

[0041] The main body portion 57, which protrudes from the tubular portion 56, has a shape that is curved in one direction. This allows the light irradiation portion 58 to be directed in various directions by rotating the main body portion 57 around the axial direction. The main body portion 57 is made of a deformable material and can take on a straight shape when housed in the tubular portion 56.

[0042] As shown in Figures 7 and 8, the support portion 60 has a conical shape that extends from the main body portion 57 toward the irradiation surface, and forms a space S inside. The support portion 60 is made of a translucent material such as glass or resin. The material forming the support portion 60 may be hard or soft, but using a soft material can reduce the risk of damaging the biological surface.

[0043] A contact end surface 62 is formed on the side of the support portion 60 opposite to the main body portion 57. By bringing the contact end surface 62 into contact with the living body, a space is formed between the light irradiation portion 58 and the irradiation surface, and the distance between the light irradiation portion 58 and the irradiation surface is maintained at a constant level. As shown in Figure 8, if the support portion 60 is made of a soft material, an elastic member 64 that maintains its shape is provided at the tip of the support portion 60. Alternatively, if the support portion 60 is made of a hard material, a flexible member may be provided at the tip of the support portion 60.

[0044] The medical device 12 of this embodiment is also suitable for application to elevated lesions or invasive lesions because it irradiates excitation light by bringing the support portion 60 into contact with the living body.

[0045] As shown in Figure 8, the main unit 57 also holds a camera 59 positioned next to the light irradiation unit 58. The camera 59 allows for confirmation of the irradiation status from the light irradiation unit 58 and detection of fluorescence in the lesion.

[0046] As shown in Figure 9, the support portion 60 may have an opening 66 in a part of its circumferential direction. This allows the irradiation state of the excitation light from the light irradiation portion 58 to be directly observed by a camera or the like inserted into the body separately.

[0047] As shown in Figure 10, the contact end surface 62 of the support portion 60 may be provided with a marking portion 68 that marks the biological surface that the contact end surface 62 comes into contact with. The marking portion 68 can be configured, for example, as a discharge structure that discharges ink made of a material that does not affect biological tissue when in contact, or as a groove structure that can be pre-applied with the ink. By forming a marking 69 on the biological surface with the marking portion 68, the operator can visually confirm the area irradiated with excitation light, preventing overlapping irradiation and missed irradiation, and enabling efficient light irradiation.

[0048] The marking portion 68 may be a suction portion that generates negative pressure on the surface of the contact end face 62. This allows the negative pressure generated by the marking portion 68 to cause congestion in the body when the contact end face 62 comes into contact with the body, thereby forming a mark 69. In this case, since the contact end face 62 is adsorbed to the surface of the body, it can also function as a fixing portion that fixes the support portion 60 to the body.

[0049] As shown in Figure 11, the support portion 60 may be configured to accommodate an expanding adapter 70 attached to the contact end surface 62. The expanding adapter 70 may be attached using a well-known fitting structure, or it may be attached using an adhesive that does not affect biological tissue. When attached to the contact end surface 62, the expanding adapter 70 is formed to expand in diameter from the main body portion 57 toward the irradiation surface, continuous with the support portion 60. By providing the expanding adapter 70, the irradiation range can be changed according to the size of the lesion. The expanding adapter 70 can also be used to change the distance between the light irradiation portion 58 and the irradiation surface.

[0050] As shown in Figure 12, the support portion 80 may be formed from a self-expanding wire. The support portion 80 has a plurality of circumferential support wire portions 81 that extend from the main body portion 57 so as to expand in diameter toward the irradiation surface, and a tangent wire portion 82 that connects the plurality of support wire portions 81 along the circumferential direction at the end on the irradiation surface side. The tangent wire portion 82 has a contact end surface 82a. The tangent wire portion 82 also has a plurality of inflection portions 83 along the circumferential direction. The tangent wire portion 82 can be bent starting from the inflection portions 83.

[0051] As shown in Figure 13, the support portion 80 is in a contracted state when housed in the storage sheath 85. The support portion 80 is folded into a contracted state in the circumferential direction by bending at each inflection portion 83. By moving the support portion 80 axially and exposing it to the outside of the storage sheath 85, the support portion 80 self-expands and can take on an expanding diameter shape extending from the main body portion 57 toward the irradiation surface, as shown in Figure 12. In this way, by forming the support portion 80 with a self-expanding wire, the diameter can be reduced to make it easier to insert when delivering the support portion 80 to the vicinity of the lesion. In addition, since there is space between adjacent tangent portions 82 in the circumferential direction, the irradiation state and fluorescence can be easily confirmed.

[0052] The treatment method using the medical device 12 of this embodiment is the same as the treatment method using the medical device 10 of the first embodiment in the steps prior to performing the light irradiation procedure. In this embodiment, the operator approaches the lesion under endoscopy. The operator inserts the tubular body 56 containing the support part 60 into the body, and when the tip reaches the vicinity of the lesion, operates the retractable operation part 53 to extend the main body 57 and the support part 60 from the tubular body 56, and while changing the orientation of the support part 60 by operating the rotation operation part 55, the contact end surface 62 of the support part 60 is brought into contact with the periphery of the lesion, and the light irradiation part 58 is positioned opposite the lesion. By maintaining the state in which the support part 60 is in contact with the body, the distance between the lesion and the light irradiation part 58 can be kept constant. In this state, the operator operates the irradiation operation part 54 of the housing 50 to supply excitation light to the light irradiation part 58. This allows excitation light to be irradiated from the light irradiation part 58 to the lesion. The subsequent steps are the same as the treatment method of the first embodiment.

[0053] As described above, the medical device 10 according to this embodiment is a medical device 10 that destroys tumor cells by irradiating photosensitive substances accumulated in a tumor with excitation light, and comprises a light irradiation unit 40 that irradiates the photosensitive substances with excitation light, a main body 20 that holds the light irradiation unit 40 so that it faces in a certain direction, and a support unit 30 that extends from the main body 20 toward the side toward which the light irradiation unit 40 faces, and the support unit 30 has a contact end surface 32 on the opposite side from the main body 20 that maintains a constant distance between the light irradiation unit 40 and the irradiation surface P, and also forms a space S between the light irradiation unit 40 and the irradiation surface P. With the medical device 10 configured in this way, by bringing the contact end surface 32 of the support unit 30 into contact with the living body, the distance and angle between the light irradiation unit 40 and the irradiation surface P are maintained at a constant level, and the irradiation state toward the lesion can be stably maintained.

[0054] Furthermore, the support portion 30 may be made translucent. This allows the irradiation state from the light irradiation portion 40 and the fluorescence of the lesion to be observed visually or through imaging devices such as an endoscope or surgical field camera.

[0055] Furthermore, the support portion 30 may have an opening 36 in a part of its circumferential direction, allowing the space S to be directly viewed through the opening 36. This makes it possible to improve the visibility or observation of the irradiation state from the light irradiation portion 40 and the fluorescence of the lesion. Moreover, it becomes possible to ensure visibility regardless of the material of the support portion 30.

[0056] Furthermore, the support portion 30 may be formed so that its diameter expands from the main body portion 20 toward the irradiation surface P at an angle equivalent to the angle that the excitation light from the light irradiation portion 40 makes with respect to the irradiation surface P. This ensures that the space S within the support portion 30 is of sufficient size.

[0057] Furthermore, the main body 20 may have an adjustment mechanism 25 for adjusting and fixing the position of the light irradiation unit 40 in the direction of the optical axis. This allows for appropriate adjustment of the optical axis position of the light irradiation unit 40. In addition, the range over which excitation light is irradiated can be adjusted when the contact end surface 32 of the support unit 30 comes into contact with a living organism.

[0058] Furthermore, the support portion 30 may have a contact detection unit 34 that detects the contact state of the abutment end surface 32 with the living body. This allows the contact state of the support portion 30 with the living body to be recognized, and ensures reliable light irradiation.

[0059] Furthermore, the support portion 30 may have a marking portion 68 that marks the biological surface in contact with the contact end surface 32. This allows the area treated with light irradiation to be visually identified, enabling efficient and reliable light irradiation.

[0060] Furthermore, the support portion 30 is formed in an expanding shape from the main body portion 20 toward the irradiation surface P, and a diameter-expanding adapter 70, which is continuous with the support portion 30 and extends toward the irradiation surface P toward the main body portion 20, may be detachably attached to the contact end surface 32. This makes it possible to change the range to which the excitation light is irradiated, or to change the distance between the light irradiation portion 40 and the irradiation surface P, as needed.

[0061] Furthermore, the support portion 30 may be formed from a self-expanding wire having a plurality of circumferential support wire portions 81 that extend from the main body portion 20 so as to expand in diameter toward the irradiation surface P, and a tangent wire portion 82 that connects the plurality of support wire portions 81 at the end on the irradiation surface P side. This allows the support portion 30 to be housed in a storage sheath 85 or the like to reduce its diameter and facilitate insertion into a living body.

[0062] Alternatively, the main unit 20 may be configured to hold the camera 59 in a position adjacent to the light irradiation unit 40. This allows for direct observation of the irradiation state from the light irradiation unit 40 and the fluorescence of the lesion.

[0063] It should be noted that the present invention is not limited to the embodiments described above, and various modifications can be made by those skilled in the art within the technical framework of the present invention. [Explanation of Symbols]

[0064] 10 Medical Devices 12 Medical Devices 20 Main body 22 Gripping part 24 Holding part 25 Adjustment mechanism 25a Fastening section 25b Adjustment screw 30 Support part 32 Contact end surface 34 Contact detection unit 36 Opening 37 Opening 40 Light-irradiating section 41 Optical waveguide for irradiation 42 Light-emitting part 43 Cables 45 Cables 46 Light-irradiating section 47 Cameras 50 cabinets 52 Gripping part 53 Appearance control section 54 Irradiation operation section 55 Rotary operation section 56 Tubular part 57 Main body 58 Light-irradiating section 59 Cameras 60 Support part 62 Contact end surface 64 Elastic members 66 openings 68 Marking application section 69 Marking 70 Diameter expansion adapter 80 Support part 81 Support line section 82 Contact line part 82a Contact end surface 83 Inflection 85 Storage Sheath P Irradiation surface S space

Claims

1. A medical device that destroys tumor cells by irradiating photosensitive substances accumulated in tumors with excitation light, A light irradiation unit that irradiates the aforementioned photosensitive material with excitation light, A main body that holds the light-emitting part so that it faces in a certain direction, It has a support portion extending from the main body portion toward the light irradiation portion, The support portion has a contact end surface on the opposite side of the main body that maintains a constant distance between the light irradiation portion and the irradiation surface when in contact with a living body, and forms a space between the light irradiation portion and the irradiation surface, and the support portion has a contact detection portion that detects the contact state of the contact end surface with the living body. A medical device further comprising a notification unit that notifies the contact state of the contact end surface with respect to a living organism, as detected by the contact detection unit.

2. The medical device according to claim 1, wherein the support portion is translucent.

3. The medical device according to claim 1 or 2, wherein the support portion has an opening in a part in the circumferential direction, and the space portion can be directly viewed through the opening.

4. The medical device according to any one of claims 1 to 3, wherein the support portion is formed such that it expands in diameter from the main body portion toward the irradiation surface at an angle equivalent to the angle that the spread of the excitation light from the light irradiation portion makes with respect to the irradiation surface.

5. The medical device according to any one of claims 1 to 4, wherein the main body portion has an adjustment mechanism for adjusting and fixing the position of the light irradiation portion in the direction of the optical axis.

6. The medical device according to any one of claims 1 to 5, wherein the support portion has a marking portion that marks the biological surface in contact with the contact end surface.

7. The support portion is formed in an expanding diameter shape from the main body portion toward the irradiation surface, The medical device according to any one of claims 1 to 6, wherein a diameter-expanding adapter, which is continuous with the support portion and extends from the main body portion toward the irradiation surface, is detachably attached to the contact end surface.

8. The medical device according to claim 1, wherein the support portion is formed of a self-expanding wire having a plurality of circumferential support wire portions extending from the main body portion toward the irradiation surface in an expanding diameter direction, and a tangent wire portion connecting the plurality of support wire portions at the end on the irradiation surface side.

9. The medical device according to any one of claims 1 to 8, wherein the main body holds a camera so as to be placed alongside the light irradiation unit.

Images