Methods for controlling creeping pests

Abstract

The present invention relates to a crawling pest control method that involves volatilization of a control composition that contains a pyrethroid compound. The crawling pest control method is characterized in that the control composition is volatilized within a space to keep the in-air concentration of the pyrethroid compound within the space at 1–100 μg / m3 and prevent establishment of crawling pests within the space.

Description

Technical Field

[0001] The present invention relates to a method for controlling crawling pests.

Background Art

[0002] Conventionally, various formulations such as aerosol agents, fumigants, and bait agents have been used for the purpose of controlling crawling pests such as cockroaches.

[0003] For example, aerosol agents that are generally used to control crawling pests by directly spraying the active ingredient onto them are widely used. In addition, fumigants are known to control crawling pests by the active ingredient diffused into the space by heating coming into contact with the crawling pests or the crawling pests inhaling the active ingredient.

[0004] However, the above-mentioned agents may cause the dead bodies of the crawling pests to come into view when they are controlled, which may give discomfort to the user. In addition, control with aerosol agents or fumigants may cause the crawling pests to become excited or flash out (the phenomenon of jumping out from hiding places) due to the active ingredient causing nerve excitation in the crawling pests, which may give discomfort to the user. Furthermore, since fumigants diffuse the active ingredient into the indoor space, there is a need for the user to leave the space during treatment or to cover fire alarms, etc. Excessive use of the above-mentioned agents to control crawling pests may also contribute to the development of drug resistance.

[0005] On the other hand, cockroach repellents for repelling cockroaches, which are one type of crawling pests, have been studied. For example, in Patent Document 1, a cockroach repellent, which is an extract obtained by immersing at least one plant piece selected from the group consisting of dill, celery, caraway, cumin, cinnamon, mace, and pepper in a solvent, is disclosed.

Prior Art Documents

Patent Documents

[0006]

Patent Document 1

Summary of the Invention

Problems to be Solved by the Invention

[0007] The cockroach repellent described in the above Patent Document 1 is used by spraying or applying it to the drawers or cupboards in the kitchen where cockroaches appear. Thus, many of the conventional repellents directly treat relatively narrow spaces or enclosed spaces without human access, and there is not much known about means that can stably show the control effect of crawling pests for a long time in a wide space such as the entire indoor space or a space with human access.

[0008] Therefore, an object of the present invention is to provide a method for controlling crawling pests that can stably provide a comfortable space without crawling pests for a long time, without causing nerve excitation or leaving carcasses in the space. Another object of the present invention is to provide a method for suppressing the activity of crawling pests in a space.

Means for Solving the Problems

[0009] As a result of intensive research to solve the above problems, the present inventor has come to the idea that if crawling pests can be moved from inside the space to the outside when they are lurking and breeding inside the space or invading from the outside, their establishment inside the space can be prevented and a comfortable space can be realized. And as a result of further examination, it has been found that by using a specific active ingredient and maintaining the airborne concentration of the above active ingredient within a certain range in the space, the establishment of the above crawling pests inside the space can be prevented, and the present invention has been completed.

[0010] That is, the present invention relates to the following [1] and [2]. [1] A method for controlling crawling pests by volatilizing a control composition containing a pyrethroid compound, The volatilization of the aforementioned pest control composition into the space reduces the airborne concentration of the pyrethroid compound in the space to 1-100 μg / m³. 3 A method for controlling crawling insects, characterized by maintaining them within a certain range and preventing the crawling insects from settling into the space. [2] A method for controlling creeping insects, comprising heating and vaporizing a control composition containing a pyrethroid compound, By heating and evaporating the aforementioned pest control composition into the space, the airborne concentration of the pyrethroid compound in the space is reduced to 1 to 100 μg / m³. 3 A method for controlling crawling insects, characterized by maintaining them within a certain range and preventing the crawling insects from settling into the space. [Effects of the Invention]

[0011] The crawling insect control method according to the present invention prevents crawling insects from settling into a space, thus providing a comfortable environment for a long period of time without causing nervous excitement in the crawling insects or leaving their carcasses in the space. Furthermore, even if crawling insects enter the space from the outside, it is possible to encourage them to move back outside, thereby preventing them from settling into the space. Furthermore, by treating a closed space with the control composition in the crawling insect control method according to the present invention, the activity of crawling insects within the closed space can also be suppressed. [Brief explanation of the drawing]

[0012] [Figure 1] Figure 1 is a schematic diagram illustrating the test method for inhibiting the establishment of creeping insect pests. [Figure 2] Figure 2 is a schematic diagram illustrating the test methods for inhibiting the activity, feeding, and reproduction of cockroaches. [Figure 3] Figure 3 is a graph showing the change in the number of survivors over time in the evaluation of growth inhibition. [Figure 4] Figure 4 is a graph showing the change in the egg-laying rate over time in the evaluation of proliferation inhibition. [Figure 5]Figure 5 is a graph showing the change in the number of eggs laid over time in the evaluation of proliferation suppression. [Modes for carrying out the invention]

[0013] <How to control creeping pests> The crawling insect control method according to this embodiment (hereinafter sometimes simply referred to as the "control method") involves volatilizing a control composition containing a pyrethroid compound. By volatilizing the control composition into the air, the airborne concentration of the pyrethroid compound in the air is increased to 1 to 100 μg / m³. 3 Maintain the area within this range. This prevents crawling insects from settling into the space and allows for control of crawling insects.

[0014] The control method according to this embodiment can prevent crawling insects from settling into a space. Preventing settlement in a space is different from repellents that suppress entry into the space; it means encouraging crawling insects to move to the outside, even if they are lurking and breeding in the space or have entered from the outside.

[0015] In the pest control method according to this embodiment, a pyrethroid compound is used as the active ingredient, and the airborne concentration of the pyrethroid compound in the space is set to 1 to 100 μg / m³. 3 By maintaining it within this range, the above-mentioned inhibitory effect on establishment can be achieved.

[0016] The airborne concentration of pyrethroid compounds in a space can be adjusted by the material and size of the carrier, such as the absorbent wick or mat described later, the heating temperature, the composition of the pest control composition, and the concentration of the pyrethroid compound, which is the active ingredient in the pest control composition.

[0017] The airborne concentration of pyrethroid compounds in the space is 1 μg / m³. 3 Maintaining the above level prevents crawling insects from settling into the air. The above airborne concentration is 1.5 μg / m³. 3 The above is preferable, 3 μg / m² 3 The above is preferable. On the one hand, from the perspective of the safety for the human body, and from the perspectives of preventing the death or knockdown of crawling pests that cause discomfort to users and preventing flushing out due to nerve excitation, the airborne concentration of the pyrethroid compound in the space should be 100 μg / m 3 or less, preferably 90 μg / m 3 or less, and more preferably 80 μg / m 3 or less.

[0018] It is preferable that the above airborne concentration is constant throughout the space where the control composition volatilizes. Thereby, no matter where the crawling pests are in the space, they dislike the space itself, and the effect of preventing settlement is more exerted. According to the size of the space, the volatilization mode, temperature, time, composition of the control composition, concentration, etc. are appropriately adjusted. In addition, the fact that the airborne concentration is constant throughout the space means that when the airborne concentration is measured at any height from 10 to 150 cm at the measurement position in the space, the difference in the airborne concentration is ±10 μg / m 3 or less.

[0019] The volatilization of the control composition into the space includes dosage forms such as natural evaporation agents, fan-type formulations, piezo-type automatic spraying formulations, heating evaporation agents, etc. Among them, from the perspective of making the airborne concentration of the pyrethroid compound constant throughout the space regardless of the evaporation property of the pyrethroid compound contained in the volatilizing control composition, natural evaporation agents, fan-type formulations, and heating evaporation agents are preferable, and from the perspective of making the influence by the environment of the space where the control composition volatilizes smaller, heating evaporation agents are more preferable. In addition, the above environment means temperature, ventilation conditions, presence or absence and intensity of wind inflow, etc. That is, for the method for controlling crawling pests according to this embodiment, it is more preferable to maintain the airborne concentration of the pyrethroid compound in the space within a predetermined range by heating and evaporating the control composition into the space.

[0020] A naturally evaporating agent refers to a pest control composition that is supported on a carrier and allowed to evaporate naturally without the use of artificial means such as blowing air or heating. Examples of carriers include paper, yarn (twisted yarn, etc.), nonwoven fabric, wood, pulp, inorganic polymers, inorganic porous materials (silicates, silica, zeolite, etc.), organic polymers (cellulose, polyethylene, polypropylene, polyvinyl alcohol, etc.), sublimable materials (adamantane, cyclododecane, paradichlorobenzene, naphthalene, camphor, etc.), resin plates, evaporative sheets, and oil-absorbing polymers. One or more of these can be used in combination. The method of support is not particularly limited and can include dropping, immersion, kneading, etc.

[0021] A fan-type formulation refers to a method in which a pest control composition is supported on a carrier and evaporated by airflow using a fan. The carrier is made of a material that does not hinder the diffusion of the liquid pest control composition, and is designed to impregnate and support the composition. Examples of carriers include permeable porous materials such as organic polymers, nonwoven fabrics, cotton, sponges, and open-cell foams. The method of support is not particularly limited and can include dropping, immersion, kneading, etc.

[0022] A piezoelectric automatic spray formulation refers to a system in which a carrier attached to a bottle filled with a pest control composition is brought into contact with a metal plate from the back side to supply the pest control composition, and the composition is vaporized by ultrasonic vibration of a piezoelectric element (piezo). When an absorbent core is used as the carrier, for example, a core material formed into a rod shape from felt, sponge, cotton, or porous material can be used.

[0023] A heat-activated vaporizing agent refers to a substance that allows a pest control composition supported on a carrier to be stably vaporized by applying heat.

[0024] The heating temperature during heat evaporation varies depending on the type of pyrethroid compound used, but is preferably 120 to 160°C. From the viewpoint of sufficiently evaporating the pyrethroid compound, the heating temperature is preferably 120°C or higher, more preferably 125°C or higher, and even more preferably 130°C or higher. On the other hand, from the viewpoint of preventing thermal decomposition of the pyrethroid compound, the heating temperature is preferably 160°C or lower, more preferably 155°C or lower, and even more preferably 150°C or lower. In this specification, the heating temperature refers to the surface temperature of the heater in the heat evaporation device, and this surface temperature is measured by a temperature sensor (503E-TC1-ASP, manufactured by Anritsu Keiki Co., Ltd.).

[0025] In the pest control method according to this embodiment, the airborne concentration of the pyrethroid compound is set to 1 to 100 μg / m³. 3 The duration for maintaining the treatment within this range is preferably 2 to 24 hours per day, but may also be 2 to 12 hours. Here, the above daily maintenance duration is preferably 2 hours or more, more preferably 4 hours or more, and even more preferably 6 hours or more. As described above, by maintaining the treatment for a certain duration or longer, the movement of crawling insects from the treated space treated with the control composition to the untreated space is further promoted, and an even better inhibitory effect on establishment can be obtained. On the other hand, the above daily maintenance duration may be 24 hours, i.e., all day, but since a sufficient inhibitory effect on establishment can be obtained by maintaining the treatment for 12 hours per day, the maintenance duration may be 12 hours or less. The above-mentioned maintenance time range may be met by continuously volatilizing the pest control composition, or by intermittently volatilizing the pest control composition, with the sum of these actions meeting the above-mentioned maintenance time range.

[0026] In this embodiment, from the viewpoint of continuously obtaining the effect of preventing crawling insects from settling in the space, for example, if the maintenance time is 24 hours per day, it is preferable to apply it for one day or more, more preferably for three consecutive days or more, and particularly preferable for seven consecutive days or more. If the maintenance time is 12 hours per day, it is preferable to apply it for one day or more, more preferably for three consecutive days or more, and particularly preferable for seven consecutive days or more.

[0027] In the pest control method according to this embodiment, the ventilation conditions of the space in which the pest control composition is volatilized are preferably 0.1 to 20 times / hour. Here, from the viewpoint of safety to the human body and the airtightness of the building, the ventilation conditions of the above space are preferably 0.1 times / hour or more, more preferably 0.2 times / hour or more, and even more preferably 0.3 times / hour or more. Furthermore, from the viewpoint of suitably obtaining the effect of preventing crawling insects from settling in the space, the ventilation conditions of the space are preferably 20 times / hour or less, more preferably 15 times / hour or less, and even more preferably 12 times / hour or less. In this specification, the ventilation conditions of a space are a technical term meaning how many times the air in the space is replaced in one hour, and can be calculated by supplying carbon dioxide to the indoor space and measuring the decrease in its concentration due to ventilation.

[0028] Specifically, the test method, which conforms to "Hygienic Testing Methods and Commentary 2000," edited by the Pharmaceutical Society of Japan and published in 2000, will be explained below. The indoor space to be measured (V R : Volume of interior space m 3 After supplying an appropriate amount of carbon dioxide to the room, the room air is stirred to equalize the carbon dioxide concentration distribution, and the average carbon dioxide concentration C1 in the room space is measured. Then, after a certain time t has elapsed, the air is stirred thoroughly again and the average carbon dioxide concentration C1 in the room is measured. t It measures the following: It also measures the carbon dioxide concentration (C0) in the air entering the indoor space from outside. Ventilation rate V(m 3 The ventilation condition E (per hour) can be calculated using the following formula. [Calculation formula] V = 2.303 × (VR ÷t)×log{(C1-C0)÷(C t -C0)} E = V ÷ V R In this embodiment, the ventilation conditions refer to the ventilation conditions E calculated by the above test method.

[0029] In the pest control method according to this embodiment, under the ventilation conditions described above, people may enter and exit the treatment space, windows and doors may be opened, and air conditioners may be running. There are no particular restrictions on the temperature and humidity of the treatment space, as long as they are within the range expected for a typical indoor environment in a home.

[0030] The pest control method according to this embodiment can be suitably used indoors or in a space of a certain size within a room. The volume of the space used is, for example, 1 to 93.3 m³. 3 This is preferable. Here, the volume of the above space is, for example, 1 m³ 3 The above is preferable, 15.6m 3 (Equivalent to 4 tatami mats: 6.5m²) 2 (×Height 2.4m) or more is preferable, and 23.3m 3 (Equivalent to 6 tatami mats: 9.7m²) 2 A height of 2.4 m or more is even more preferable. Furthermore, from the viewpoint of keeping the airborne concentration of pyrethroid compounds constant within the space, the volume of the space used should be 93.3 m³. 3 (Equivalent to 24 tatami mats: area 38.9m²) 2 (× height 2.4m or less is preferable.) The dimensions of the space to be used are preferably such that the length of one side is 0.5m or more, more preferably 1.8m or more, even more preferably 2.5m or more, and preferably 8m or less. The height of the space to be used may be, for example, 1.8m or more, 2m or more, 10m or less, or 6m or less. Even in enclosed spaces within a treatment area, such as closets and wardrobes, opening the doors prevents the establishment of crawling insects in these spaces as well. Similarly, in bathrooms and toilets, opening the doors separating them from adjacent spaces prevents the establishment of crawling insects in both the treatment area and the adjacent spaces.

[0031] The crawling pests targeted by the control method according to this embodiment include cockroaches, bed bugs, centipedes, millipedes, pill bugs, ants, spiders, stink bugs, mites, and the like. Among these, it is preferable to target cockroaches, ants, centipedes, and mites, with cockroaches being more preferable. Examples of cockroaches include the German cockroach, American cockroach, European cockroach, Japanese cockroach, and brown cockroach. Examples of mites include house dust mites, Dermatophagoides pteronyssinus, Dermatophagoides farinae, flour mites, and predatory mites.

[0032] Examples of pyrethroid compounds include metofluthrin, transfluthrin, empenthrin, profluthrin, dimefluthrin, prallethrin, allethrin, mepafluthrin, phenothrin, permethrin, resmethrin, imiprothrin, cyphenothrin, pyrethrin, bifenthrin, fenpropathrin, cyfluthrin, monfluorothrin, etofenprox, etc. Among these, those with a vapor pressure of 1.0 × 10⁻⁶ at 25°C are particularly noteworthy. -4 It is preferable to include a room-temperature volatile pyrethroid compound with a Pa or higher energy content, and more preferably to include, for example, metofluthrin, transfluthrin, empenthrin, profluthrin, dimefluthrin, prallethrin, allethrin, mepafluthrin, etc., and even more preferably to include metofluthrin and transfluthrin from the viewpoint of diffusivity and more effective adhesion inhibition. These pyrethroid compounds may be used individually or in combination of two or more.

[0033] The amount of pyrethroid compound in the pest control composition or the amount retained on the carrier is not particularly limited as long as the airborne concentration of the pyrethroid compound in the space after volatilization is maintained within the above range. However, if the volatilization method is heat evaporation, for example, 0.2 to 16 w / v% (mass volume percent) is preferred. Here, the airborne concentration of the pyrethroid compound during heat evaporation is 1 μg / m³. 3From the viewpoint of making adjustments quicker, the above content is preferably 0.2 w / v% (mass volume percent) or more, more preferably 0.4 w / v% or more, and even more preferably 0.8 w / v% or more. Furthermore, the airborne concentration of pyrethroid compounds during heating and evaporation is 100 μg / m³. 3 From the standpoint of making adjustments easier, preventing clogging of the wick, and ensuring excellent stability of the formulation, the above content is preferably 16 w / v% or less, more preferably 14 w / v% or less, and even more preferably 12 w / v% or less. Furthermore, if the product contains two or more pyrethroid compounds, it is preferable that their total content be within the above range.

[0034] Furthermore, when the volatilization method is a natural evaporation agent or a fan-type formulation, the above content or retention amount is preferably, for example, 0.01 to 1 g / g.

[0035] The particle size of the pest control composition is not particularly limited as long as the airborne concentration of pyrethroid compounds in the space when the pest control composition is volatilized can be maintained within the above range, but for example, it may be 0.01 to 15 μm. Here, from the viewpoint of increasing diffusibility into the space, the particle size is preferably 15 μm or less, more preferably 13 μm or less, and even more preferably 11 μm or less. The lower limit of the particle size is not particularly limited, but for example, it is 0.01 μm or more. In this specification, the particle size of the pest control composition refers to the median diameter of the pest control composition when volatilized into a space. Specifically, in a sealed 6-tatami mat space (area 9.7 m²) at approximately 25°C. 2 The pest control composition is volatilized within a space (2.4 m high), and particles are collected for 6 hours using a particle size analyzer (Andersen type low-pressure cascade impactor) installed in the space. The mass distribution for each particle size can then be measured, and the median diameter can be calculated.

[0036] The pest control composition only needs to contain a pyrethroid compound; other components are optional. Other components include, for example, solvents, as well as additives such as emulsifiers, binders, dispersants, stabilizers, volatilization regulators, antioxidants, disinfectants, fungicides, deodorizers, fragrances, and colorants, and conventionally known additives can be used.

[0037] The solvent is not particularly limited, but examples include water; aliphatic hydrocarbons (paraffinic hydrocarbons and unsaturated aliphatic hydrocarbons) with boiling points of 150 to 350°C such as hexane, kerosene, lamp oil, n-paraffin, isoparaffin, and cycloparaffin; aromatic hydrocarbons such as benzene, toluene, and xylene; halogenated hydrocarbons such as dichloroethane and carbon tetrachloride; alcohols such as ethanol, isopropyl alcohol, ethylene glycol, and hexylene glycol; ketones such as acetone, methyl ethyl ketone, and cyclohexanone; ethers such as tetrahydrofuran, dimethoxyethane, and diethyl ether; esters such as ethyl acetate and hexyl laurate; nitriles such as acetonitrile; and acid amides such as dimethylformamide. From the viewpoint of stably and continuously volatilizing the pest control composition over a long period of time, aliphatic hydrocarbons (paraffinic hydrocarbons and unsaturated aliphatic hydrocarbons) are preferred as the solvent. Note that one solvent may be used alone, or two or more solvents may be used in combination.

[0038] Emulsifiers, binders, and dispersants are not particularly limited, but examples include surfactants such as soaps, polyoxyethylene alkyl allyl ethers, polyoxyethylene fatty acid esters, glycerin fatty acid esters, sorbitan fatty acid esters, sulfate esters of higher alcohols, and alkyl allyl sulfonates.

[0039] Stabilizers, not particularly limited, include, for example, dibutylhydroxytoluene (BHT), butylhydroxyanisole (BHA), 3,5-di-t-butyl-4-hydroxyanisole, mercaptobenzimidazole, dilauryl-thio-dipropionate, 2,2'-methylenebis-(6-t-butyl-4-methylphenol), 2,2'-methylenebis-(6-t-butyl-4-ethylphenol), 4,4'-methylenebis-(2,6-di-t-butylphenol), and 4,4'-butyllidenebis-(6-t-butyl-3-methylphenol). Examples include trimethylphenol, 4,4'-thiobis-(6-t-butyl-3-methylphenol), 1,1-bis-(4-hydroxyphenyl)cyclohexane, 1,3,5-trimethyl-2,4,6-tris(3,5-di-t-butyl-4-hydroxybenzyl)benzene, tris(2-methyl-4-hydroxy-5-t-butylphenyl)butane, tetrakis[methylene(3,5-di-t-butyl-4-hydroxyhydrocinnamate)]methane, octadecyl-3,5-di-t-butyl-4-hydroxyhydrocinnamate, etc.

[0040] The volatilization regulator is not particularly limited, but examples include tricyclodecane, cyclododecane, 2,4,6-triisopropyl-1,3,5-trioxane, trimethylenenorbornene, and the like.

[0041] Antioxidants are not particularly limited, but examples include dibutylhydroxytoluene (BHT), butylhydroxyanisole (BHA), ascorbic acid, diethyl (3,5-di-t-butyl-4-hydroxybenzyl)phosphonate, and vitamins.

[0042] The fungicides and antifungal agents are not particularly limited, but examples include isopropylmethylphenol, parachlorometaxylenol, triclosan, 3-iodomethyl-2-propenylbutylcarbamate, 2-(4-thiazolyl)benzimidazole, cetylpyridium chloride, 4,4-dimethyl-1,3-oxazolidine, polyhexamethylene biguanide hydrochloride, hinokitiol, and essential oils such as origanum oil, cinnamon oil, lemongrass oil, peppermint oil, and eucalyptus oil.

[0043] Deodorizers and odor removers are not particularly limited, but examples include lauryl methacrylate, geranyl crotonate, catechin, and polyphenols.

[0044] Air fresheners can use either natural or synthetic fragrances, and blended fragrances are also acceptable. Furthermore, the type of fragrance can be either animal-derived or plant-derived.

[0045] Natural fragrances are not limited to animal-derived fragrances such as musk, citrine, ambergris; rose oil, lavender oil, rosemary oil, peppermint oil, lemon oil, abies oil, ajwain oil, almond oil, angelica root oil, basil oil, bergamot oil, birch oil, bois de rose oil, cajeput oil, cananga oil, capsicum oil, caraway oil, cardamom oil, cassia oil, celery oil, cinnamon oil, citronella oil, Examples of plant-based fragrances include cognac oil, coriander oil, cubeb oil, garlic oil, ginger oil, grapefruit oil, hop oil, juniper berry oil, laurel leaf oil, lemongrass oil, lovage oil, mace oil, nutmeg oil, mandarin oil, tangerine oil, mustard oil, orange blossom oil, onion oil, pepper oil, orange oil, sage oil, star anise oil, turpentine oil, wormwood oil, and vanilla oil.

[0046] Synthetic fragrances or blended fragrances are not particularly limited, but examples include hydrocarbons such as pinene and limonene; alcohols such as linalool, geraniol, citronellol, menthol, borneol, benzyl alcohol, and anise alcohol; phenols such as anethole and eugenol; aldehydes such as n-butyraldehyde, isobutyraldehyde, citral, citronellal, benzaldehyde, cinnamic aldehyde, and vanillin; ketones such as carvone, menthone, and camphor; lactones or oxides such as amyl butyrolactone, ethyl methylphenylglycidate, γ-nonyl lactone, coumarin, and cineole; and esters such as isopropyl isobutyrate, geranyl isovalerate, ethyl myristate, ethyl benzoate, benzyl benzoate, cinnamyl cinnamate, and methyl salicylate.

[0047] The colorants are not particularly limited, but examples include Red No. 213, Red No. 214, Red No. 215, Red No. 218, Red No. 223, Red No. 225, Orange No. 201, Orange No. 206, Yellow No. 204, Green No. 202, Red No. 505, Orange No. 401, Orange No. 403, Yellow No. 401, Yellow No. 402, Yellow No. 404, Yellow No. 405, Blue No. 403, and Violet No. 201.

[0048] The pest control composition in this embodiment is used by allowing it to be absorbed by a carrier such as an absorbent core or mat, so it is preferably a liquid, and preferably has a boiling point in the range of 130°C to 350°C. In this specification, "liquid" refers to a substance that is fluid and can change shape according to the shape of the container.

[0049] The material of the carrier is not particularly limited, but various materials such as inorganic and organic materials can be used.

[0050] When using an absorbent wick as a carrier, examples of inorganic materials include clay, talc, kaolin, acid clay, diatomaceous earth, activated clay, gypsum, perlite, bentonite, alumina, silica, titanium, asbestos, and ceramics. When an absorbent core is used as a carrier, examples of organic materials include wood powder, cellulose, pulp, polyester resin, acrylic resin, and other polymer resins. Among these, at least one selected from polyester resin, acrylic resin, etc., is preferred, and when used as an absorbent core, a synthetic fiber core made by solidifying fibers of these materials is more preferred, and furthermore, a porosity of 20 to 80% is preferred.

[0051] When using a mat as a carrier, examples of inorganic materials include glass, paper obtained from inorganic fibers such as asbestos, nonwoven fabrics, inorganic powders such as graphite, CaCO3, SiO2, Al2O3, perlite, white clay, talc, sepiolite, and bentonite; and sintered metals. When using mats as carriers, examples of organic materials include natural fibers such as linters and pulp; animal and plant fibers such as wool, cotton, and silk; regenerated fibers such as rayon; synthetic fibers such as acrylic and polyester; and plastic foams such as polyethylene and polyvinylidene fluoride.

[0052] The form of the carrier is not particularly limited; for example, in the case of an absorbent core, examples include strip-shaped, cylindrical, or rod-shaped.

[0053] Volatilization in this embodiment can be carried out by conventionally known methods. For example, when using the product by absorbing liquid into an absorbent wick, the absorbent wick is attached to a bottle filled with the pest control composition of this embodiment, and the absorbent wick is brought into contact with the pest control composition to create an absorbent wick containing the pest control composition. Alternatively, when using the product by absorbing liquid into a mat, the pest control composition of this embodiment is impregnated into the mat. The absorbent wick or mat containing the pest control composition is then set in a device for volatilization and volatilized in a manner appropriate to the formulation. For example, when volatilization is performed by heating and vaporization, heating by applying electricity can be used.

[0054] When using an absorbent wick for volatilization, the pest control composition absorbed by the wick is volatilized, releasing pyrethroid compounds into the air. In this process, the airborne concentration of pyrethroid compounds in the space is 1 to 100 μg / m³.3 By maintaining the area within this range, it is possible to prevent crawling insects from establishing themselves in the space.

[0055] The present invention also relates to a crawling insect control agent comprising the above-mentioned control composition. The crawling insect control agent is used to prevent crawling insects from settling into a space and includes a control composition containing a pyrethroid compound as an active ingredient. The crawling insect control agent releases the active ingredient into the air, resulting in an airborne concentration of 1-100 μg / m³ of the active ingredient. 3 This can be done within a certain range. This prevents crawling insects from settling into the space. One embodiment of the above-mentioned crawling insect control agent is one in which heat vaporization is used as the volatilization method, that is, a heat vaporizing agent including a heat vaporization device. However, it is not limited to the above embodiment. For example, natural vaporizing agents, fan-type formulations, piezo-type automatic spray formulations, etc. may also be used.

[0056] In addition to preventing crawling insects from settling into the space, the control method according to this embodiment also has the effect of suppressing the activity, feeding, and reproduction of crawling insects. By exerting activity-inhibiting and consumption-inhibiting effects, the opportunities for contact between crawling insects and residents or food stored by residents are reduced, thereby suppressing the transmission of pathogens. By exerting a growth-inhibiting effect, it is possible to suppress the reproduction of pests within the treated area, thereby achieving long-term pest control within the treated area.

[0057] In other words, the present invention is a method for suppressing the activity of creeping insects by volatilizing a control composition containing a pyrethroid compound, wherein the volatilization of the control composition into the space reduces the airborne concentration of the pyrethroid compound in the space to 1 to 100 μg / m³. 3 This also relates to methods for suppressing the activity of creeping insects, keeping them within a certain range.

[0058] The method for suppressing the activity of crawling insects according to this embodiment involves, for example, if the crawling insect is a cockroach, increasing the airborne concentration of pyrethroid compounds in the space to 1 to 100 μg / m³. 3By maintaining this range, it is possible to suppress wandering behavior and reproductive behavior without causing an increase in activity rate associated with neural excitation. The maintenance time mentioned above is preferably 2 hours or more, more preferably 4 hours or more, and even more preferably 6 hours or more.

[0059] The method for suppressing the activity of crawling insects according to this embodiment, for example, when the crawling insect is a mite, involves increasing the airborne concentration of pyrethroid compounds in the space to 1 to 100 μg / m³. 3 By maintaining this range, it is possible to suppress wandering behavior and reproductive behavior without causing an increase in activity rate associated with neural excitation. The maintenance period described above is preferably 3 days or more, more preferably 5 days or more, and even more preferably 7 days or more.

[0060] Furthermore, the present invention relates to a method for suppressing the consumption of crawling insects by volatilizing a control composition containing a pyrethroid compound, wherein the volatilization of the control composition into the space reduces the airborne concentration of the pyrethroid compound in the space to 1 to 100 μg / m³. 3 This also relates to methods for suppressing feeding by creeping insects, which are kept within a certain range.

[0061] The method for suppressing the consumption of crawling insects according to this embodiment involves, for example, if the crawling insect is a cockroach, increasing the airborne concentration of pyrethroid compounds in the space to 1 to 100 μg / m³. 3 By maintaining the temperature within a certain range, it is possible to reduce the cockroach's appetite and suppress its consumption. The maintenance time mentioned above is preferably 2 hours or more, more preferably 4 hours or more, and even more preferably 6 hours or more.

[0062] The method for suppressing the consumption of crawling insects according to this embodiment, for example, when the crawling insect is a mite, involves increasing the airborne concentration of pyrethroid compounds in the space to 1 to 100 μg / m³. 3 Maintaining the mites within this range can reduce their appetite and suppress their feeding. The maintenance period described above is preferably 3 days or more, more preferably 5 days or more, and even more preferably 7 days or more.

[0063] Furthermore, the present invention relates to a method for suppressing the proliferation of creeping insects by volatilizing a control composition containing a pyrethroid compound, wherein the volatilization of the control composition into the space reduces the airborne concentration of the pyrethroid compound in the space to 1 to 100 μg / m³. 3 This also relates to methods for suppressing the proliferation of creeping insects, maintaining them within a certain range.

[0064] In the method for suppressing the proliferation of creeping insects according to this embodiment, the maintenance period of the above-mentioned airborne concentration is appropriately set according to the oviposition method of the creeping insects. For example, if the crawling pest is the German cockroach, it begins incubating eggs about 1-2 weeks after emerging from its pupa. Therefore, the airborne concentration of pyrethroid compounds in the space should be 1-100 μg / m³. 3 By maintaining the concentration within this range for a period of preferably one week or more, more preferably two weeks or more, the proliferation of cockroaches such as German cockroaches can be effectively suppressed. Furthermore, even when the crawling pest is a mite, the airborne concentration of pyrethroid compounds in the space should be kept between 1 and 100 μg / m³. 3 It is preferable to maintain the concentration within this range for at least one week, and more preferably for at least two weeks. For other creeping insects, considering each period from emergence or hatching to egg incubation, the airborne concentration of pyrethroid compounds in the space should be 1 to 100 μg / m³. 3 The period for maintaining this range can be set as appropriate. Furthermore, the inhibitory effect on reproduction refers to the effect of suppressing at least one selected from the group consisting of female oviposition, female incubation, and emergence or hatching of larvae from eggs or oothecae. It is preferable to suppress two or more of the above group, and more preferable to suppress all of them.

[0065] In the above methods for suppressing activity, suppressing consumption, and suppressing proliferation, the method of volatilizing the control composition is not particularly limited, and for example, natural vaporizing agents, fan-type formulations, piezo-type automatic spray formulations, heat vaporizing agents, etc., can be used as appropriate. When these methods are used together with the above methods for controlling crawling insects, a heat vaporizing agent is preferred as the formulation from the viewpoint of keeping the airborne concentration constant throughout the space. [Examples]

[0066] The present invention will be described in more detail below with reference to examples, but the present invention is not limited in any way by these examples.

[0067] 《Prevention of Retention Evaluation 1》 [Preparation of Samples 1-7] Samples 1 to 7, which are pest control compositions, were prepared by mixing each component according to the formulations shown in Table 1.

[0068] [Table 1]

[0069] [Manufacturing of heat-dispersing agents] 45 mL of each of the samples 1-7 was filled into 50 mL capacity PET (polyethylene terephthalate) containers, and the containers were sealed using an inner stopper with an absorbent wick (approximately 7.2 mm in diameter x approximately 73.5 mm in length). The above containers were attached to a heating vaporization device (Earth No-Mat: manufactured by Earth Pharmaceutical Co., Ltd.) to produce a heating vaporization agent. The heating temperature of the heating vaporization device was set to 140°C.

[0070] [Examples 1-4 and Comparative Examples 1-3] Using samples 1-7, efficacy tests for inhibiting the establishment of creeping insects and knockdown tests were conducted using heat-evaporating agents according to the methods described in (1)-(7) below. The results are shown in Table 2. In Table 2, "-" indicates that the test was not performed. (1) A partition plate 10 was installed in a 12-tatami mat test room (3.6m long x 5.4m wide x 2.4m high), dividing it into a 4-tatami mat test space A and an 8-tatami mat test space B, as shown in Figure 1. An opening 20 with a height of 1.5 cm was provided in the lower center of the partition plate 10 to allow the test insects to move between test space A and test space B. The test room was maintained at a temperature of 25±5℃, a humidity of 50~70%RH, and a ventilation condition of 0.5 times / hour. (2) A shelter 12, water 13, and solid food 14 were placed in test space B. (3) Twenty male and twenty female adult Oriental cockroaches, or twenty-five male and twenty-five adult German cockroaches, were released into test space A as test insects and allowed to acclimate. During the acclimatization period, the opening 20 of the partition plate 10 was closed to prevent the test insects from moving from test space A to test space B. (4) In test space B, each of the heat vaporizers 11, which uses samples 1 to 7 obtained above, was placed as a heat vaporizer. (5) The previously closed opening 20 was opened to allow the test insects to move freely. Simultaneously with opening the opening, electricity was started to be supplied to the heating vaporizer, and the electricity was kept on for 12 hours. The number of test insects present in test space A and test space B 12 hours after the start of electricity supply was measured as the colonization number. Test insects that were dead or knocked down were measured as the knockdown number and were not included in the colonization number. (6) As a control, the number of fixed samples in test space B was measured when no heat vaporizing agent using the sample was installed. This corresponds to "when the sample is not processed" in formula (I) below. (7) The implantation inhibition rate (%) was calculated from the number of implants and the knockdown rate (%) was calculated from the number of knockdowns using the following formulas (I) and (I)'. The test was performed twice, and the average value was used as the implantation inhibition rate. Formula (I): Retention Inhibition Rate (%) = {1 - (Number of fixations in test space B when the sample is treated / Number of fixations in test space B when the sample is not treated)} × 100 Formula (I)': Knockdown rate (%) = (Number of knockdowns) / (Number of test insects) × 100

[0071] [Measurement of airborne concentration] For the adhesion inhibition efficacy tests of Examples 1-4 and Comparative Examples 1-3 using the above samples 1-7, the airborne concentration of metofluthrin in test space B was measured by the following methods (1)-(3). The results are shown in Table 2. (1) Each of the heated vaporizers 11, using samples 1 to 7, was placed in test space B as a heated vaporizer. (2) After energizing the heated vaporizers 11 for more than 4 hours to stabilize the airborne concentration of metofluthrin in test space B, the air in test space B was drawn in at a rate of 10 L per minute for 2 hours, and metofluthrin was collected using the silica gel trap shown below. The drawing was performed with the silica gel trap fixed so that its open end was positioned 100 cm from the wall opposite the partition plate 10 of test space B and 20 cm from the floor. • Silica gel trap A glass tube (18 mm inner diameter, 100 mm length) was fitted with cotton wool at one end and filled with approximately 4 g of silica gel (Wako Gel C-100; manufactured by Wako Pure Chemical Industries, Ltd.). A silica gel trap was obtained by inserting new cotton wool at the other end and sealing it. (3) Metofluthrin was washed off with acetone, and quantitative analysis of metofluthrin was performed by gas chromatography (Shimadzu Corporation, model GC-2014). The airborne concentration of metofluthrin in test space B (μg / m³) was calculated using the following formula (II). 3 The following was calculated: The test was conducted twice, and the average value was used as the airborne concentration of metofluthrin in test space B. Formula (II): Air concentration (μg / m 3 ) = R(μg) × 1000(L / m 3 ) / S(L) In equation (II) above, R is the quantitative value of metofluthrin (μg), and S is the amount of air drawn in (L).

[0072] [Table 2]

[0073] As shown in the results in Table 2, the airborne concentration of metofluthrin, the active ingredient of the pest control composition, was 1 to 100 μg / m³. 3 In Examples 1-4, which used samples 1-4, the test insects temporarily entered test space B containing shelter 12, water 13, and solid bait 14, but no colonization was observed. On the other hand, when the airborne concentration of metofluthrin was 1 μg / m³,3 In Comparative Examples 1 and 2, which used samples 5 and 6 with concentrations below 100 μg / m³, the phenomenon of the test insects settling in test space B was observed. Furthermore, when the airborne concentration of metofluthrin was 100 μg / m³, 3 In Comparative Example 3, which used sample 7 exceeding 7, nerve excitation was observed in the test insects, resulting in their inability to perform normal behavior and thus their inability to move outside test space B, confirming a decrease in the colonization inhibitory effect. Furthermore, in Comparative Example 3, a large number of test insects were observed to be lethal or knocked down, resulting in the remains of crawling insects remaining in both test spaces A and B. Based on these results, the airborne concentration of pyrethroid compounds, which are the active ingredients of the pest control composition, is 1 to 100 μg / m³. 3 By maintaining a space in this manner, it was shown that a high level of inhibition against the establishment of German cockroaches and Oriental cockroaches in such spaces can be achieved without causing nervous excitation in crawling insects or leaving carcasses within the space. Furthermore, while the above tests were conducted using the common German cockroach, known as the susceptible German cockroach, a similar evaluation was performed using the drug-resistant German cockroach instead, and a comparable inhibitory effect on establishment was confirmed.

[0074] [Evaluation of preventing establishment (on-site)] Restaurant (floor area 45m²) 2 The effectiveness of preventing cockroach colonization in a kitchen (2.7m high) was evaluated. Specifically, a heat-dispersing agent using sample 2 and a cockroach sticky trap were placed in the kitchen. The heat-dispersing agent was energized for 12 hours, allowing the control composition of sample 2 to be heated and vaporized into the kitchen. The effectiveness of preventing cockroach colonization was evaluated using the number of German cockroaches captured in the sticky trap as an indicator. The evaluation was based on the number of German cockroaches captured in the sticky trap when only the sticky trap was installed (without the heat-dispersing agent), and the level of effectiveness was judged accordingly.

[0075] As a result, using the heat-evaporating agent from sample 2 significantly reduced the number of German cockroaches captured. Furthermore, no lethality or knockdown of German cockroaches was observed during the use of the heat-evaporating agent. Therefore, it is thought that the German cockroaches moved from inside the kitchen to the outside, preventing them from establishing themselves in the kitchen. These results demonstrate that the product exhibits a high level of effectiveness in preventing cockroach colonization, even in real-world environments where many cockroaches live and obstacles such as sinks and refrigerators are present.

[0076] 《Evaluation of preventing establishment 2》 [Preparation of samples 8 and 9] Samples 8 and 9, which are control compositions, were prepared by mixing each component according to the formulations shown in Table 3. Note that Sample 5 in Table 3 is the same as Sample 5 in "Inhibition of Establishment Evaluation 1".

[0077] [Table 3]

[0078] [Manufacturing of heat-dispersing agents] 45 mL each of samples 8 and 9 were filled into 50 mL capacity PET (polyethylene terephthalate) containers, and sealed using an inner stopper with an absorbent wick (approximately 7.2 mm in diameter x approximately 73.5 mm in length). The above containers were attached to a heating vaporization device (Earth No-Mat: manufactured by Earth Pharmaceutical Co., Ltd.) to produce a heating vaporization agent. The heating temperature of the heating vaporization device was set to 140°C.

[0079] [Examples 5, 6 and Comparative Example 1] Using the heat-evaporating agents from samples 8 and 9, efficacy tests for inhibiting the establishment of crawling insects and knockdown tests were conducted in the same manner as in [Examples 1-4 and Comparative Examples 1-3] above. However, only 20 adult males and 20 adult females of the Oriental cockroach were used as test insects. The results are shown in Table 4. For comparison, the results of Comparative Example 1, which used the heat-evaporating agent from sample 5, are also shown.

[0080] For the fixation inhibition efficacy tests of Examples 5 and 6 using the above samples 8 and 9, the airborne concentration of transfluthrin in test space B was measured using the same method as in [Measurement of Airborne Concentration] above, except that metofluthrin was replaced with transfluthrin. The results are shown in Table 4. For comparison, the results of Comparative Example 1, which used a heat-evaporating agent consisting of sample 5, are also shown.

[0081] [Table 4]

[0082] As shown in the results in Table 4, it was demonstrated that not only metofluthrin, but also transfluthrin, as the active ingredient in the control composition, exhibits a high inhibitory effect on the establishment of Oriental cockroaches in a space where the airborne concentration is maintained within a specific range.

[0083] 《Prevention of Retention Evaluation 3》 [Preparation of sample 10] Sample 10, a pest control composition, was prepared by mixing each component according to the formulation shown in Table 5. Note that Samples 5 and 7 in Table 5 are the same as Samples 5 and 7 in "Inhibition of Establishment Evaluation 1," respectively.

[0084] [Table 5]

[0085] [Manufacturing of heat-dispersing agents] Each 50 mL PET (polyethylene terephthalate) container was filled with 45 mL of sample 10 and sealed with a stopper fitted with an absorbent wick (approximately 7.2 mm in diameter and 73.5 mm in length). The above containers were attached to a heating vaporization device (Earth No-Mat: manufactured by Earth Pharmaceutical Co., Ltd.) to produce a heating vaporization agent. The heating temperature of the heating vaporization device was set to 140°C. Furthermore, the heating vaporization agent used with sample 5 or sample 7 was the same as the heating vaporization agent used with sample 5 or sample 7 in "Settlement Inhibition Evaluation 1".

[0086] [Example 7 and Comparative Examples 4 and 5] Using heat-evaporating agents prepared with samples 10, 5, and 7, respectively, efficacy tests for inhibiting the establishment of creeping insects and knockdown tests were conducted in the same manner as in [Examples 1-4 and Comparative Examples 1-3] above. However, 20 reticulated ants were used as test insects. The results are shown in Table 6.

[0087] For the adhesion inhibition efficacy tests of Example 7, Comparative Example 4, and Comparative Example 5 using the above samples 10, 5, and 7, the airborne concentration of metofluthrin in test space B was measured using the same method as described in [Measurement of Airborne Concentration] above. The results are shown in Table 6.

[0088] [Table 6]

[0089] As shown in the results in Table 6, it was demonstrated that even against creeping ants, the reticulated ant, maintaining the airborne concentration of the active ingredient of the control composition within a specific range in the space resulted in a high inhibitory effect on its establishment without causing nerve excitation or leaving dead ants in the space. On the other hand, when the airborne concentration of metofluthrin was 100 μg / m³ 3 In Comparative Example 5, which used sample 7 exceeding a certain value, lethality or knockdown was frequently observed, resulting in a large amount of dead insects, such as the creeping ant, remaining in the space.

[0090] 《Prevention of Retention Evaluation 4》 [Example 8 and Comparative Example 6] Using the heat-evaporating agent obtained from sample 2 in Example 2 and sample 7 in Comparative Example 3, an efficacy test was conducted to inhibit the establishment of the creeping insect, Scolopendra subspinipes. The establishment inhibition efficacy test was performed by the following methods (1) to (7). (1) A 12-tatami mat test room (3.6m long x 5.4m wide x 2.4m high) was divided into two test spaces, a 4-tatami mat space A and an 8-tatami mat space B, by installing a partition board. A 1.5cm high opening was made in the lower center of the partition board to allow the test insects to move between test space A and test space B. The test room was maintained at a temperature of 25±5℃, a humidity of 50~70%RH, and a ventilation rate of 0.5 air changes per hour. (2) A shelter was set up in test space B. The shelter was moistened with water to make it easier for the test insect, Scolopendra subspinipes, to settle in. (3) One centipede, Scolopendra subspinipes, was released into test space A as a test insect and allowed to acclimate. During the acclimatization period, the opening of the partition plate was closed to prevent the test insect from moving from test space A to test space B. (4) In test space B, a heat-evaporating agent using either sample 2 or sample 7 obtained above was placed. (5) After applying power to the heating vaporizer and confirming that the airborne concentration of metofluthrin in test space B had stabilized, the closed opening was opened to allow the test insects to move freely. The test was considered to have started when the test insects first entered test space B. The average time spent inside the shelter in test space B was measured by visual observation for 3 minutes after the start of the test, and the location where the insects settled was observed 12 hours after the start of the test. (6) As a control, test space B was set to an untreated state without the installation of a heat vaporizing agent using the sample. Similarly, the test was started when the test insect first entered test space B, and the average time spent inside the shelter in test space B was measured by visual observation for 3 minutes after the start of the test. In addition, the settlement location of the test insect was observed 12 hours after the start of the test. (7) Each of the above tests was performed twice. The reason for using one specimen of Scolopendra subspinipes in each of the two tests was to prevent cannibalism among the Scolopendra subspinipes, which can occur when multiple specimens are used in the test at once. The results are shown in Table 7.

[0091] [Table 7]

[0092] As shown in the results in Table 7, the centipede *Scolopendra subspinipes* prefers to stay in humid, dark places such as shelters due to its habits. However, in the above test, in Example 8, the average time spent inside the shelter in test space B by the test insects during the first 3 minutes after the start of the test was 0.4 minutes. In contrast, in the control group, which was untreated without the installation of a heat vaporizing agent using the specimens, the average time spent inside the shelter in test space B by the test insects was 3 minutes. Furthermore, 12 hours after the start of the experiment, in Example 8, the test insects were in test space A on both occasions, whereas in the control group, they were in the shelter within test space B on both occasions.

[0093] On the other hand, as shown in Comparative Example 6, the airborne concentration was 100 μg / m³. 3 Despite the extremely high temperature, the results showed that the organism settled in test space B, which had the heating vaporizer installed, rather than in test space A, which did not have the heating vaporizer installed. In Comparative Example 6, approximately one hour after the start of the test, the test insects were observed moving back and forth between test space A and test space B, and grooming themselves in the corners of test space B. Furthermore, 12 hours after the start of the test, the test insects were observed to have been knocked down in test space B. This is thought to be because exposure to the control composition in test space B increased the time the test insects spent grooming themselves in the corners of test space B, thereby increasing the probability of being knocked down in test space B. In addition, prior to the knockdown, the test insects, Scolopendra subspinipes, were observed to be experiencing nerve excitation. Thus, the airborne concentration is 100 μg / m³. 3 When the number of centipedes exceeds a certain level, it has been confirmed that the nervous system excitation of the centipedes can cause discomfort and fear in residents, increasing the risk of bites and the likelihood of dead centipedes remaining in the space.

[0094] As shown in the results above, it has been demonstrated that even against creeping insects like the giant centipede (Scolopendra subspinipes), maintaining the airborne concentration of the active ingredient of the control composition within a specific range in a space exhibits a high inhibitory effect on their establishment within that space, without causing nerve excitation or leaving carcasses behind.

[0095] 《Prevention of Retention Rating: 5》 [Preparation of samples 11 and 12] Samples 11 and 12, which are pest control compositions, were prepared by mixing each component according to the formulations shown in Table 8.

[0096] [Table 8]

[0097] [Manufacturing of naturally evaporating agents] A PET (polyethylene terephthalate) net-like carrier (14 cm long x 27 cm wide, with an open area of ​​15%) was fixed to a plastic frame (17.5 cm long x 31.5 cm wide), and a naturally evaporating agent was produced by infusing 1500 mg of sample 11 or sample 12 into the net-like carrier.

[0098] [Example 9 and Comparative Example 7] Using naturally evaporating agents with samples 11 and 12, efficacy tests for inhibiting the establishment of creeping insects and knockdown tests were conducted. Specifically, the experiment was conducted under the same conditions as the adhesion inhibition efficacy test and knockdown test in "Adhesion Inhibition Evaluation 1," except that the above-mentioned naturally evaporating agent was used instead of the heated evaporating agent, and the location of the naturally evaporating agent was set in a well-ventilated area with a wind speed of approximately 0.1 m / s, near the center of test space B, at a height of 120 cm from the floor. The results are shown in Table 9.

[0099] [Table 9]

[0100] As shown in the results in Table 9, even when using a naturally evaporating agent, the airborne concentration of metofluthrin was 1 to 100 μg / m³. 3 In Example 9, which used sample 11, although the test insects temporarily entered test space B, no phenomenon of colonization was observed. Based on these results, the airborne concentration of pyrethroid compounds, the active ingredients of the control composition, when using a naturally evaporating agent was 1 to 100 μg / m³. 3By maintaining a space in this manner, it was shown that a high level of inhibition of colonization by creeping insects can be achieved without causing nervous excitation in them or leaving their carcasses within the space.

[0101] 《Inhibition of Retention Evaluation 6》 [Preparation of samples 13 and 14] Samples 13 and 14, which are pest control compositions, were prepared by mixing each component according to the formulations shown in Table 10.

[0102] [Table 10]

[0103] [Manufacturing of fan-type formulations] PET (polyethylene terephthalate) net-like carrier (14cm 2 A fan-type formulation was manufactured by applying 150 mg of sample 13 or sample 14 to the sample and fixing it to a drug volatilization device (Osoto de No-Mat, manufactured by Earth Pharmaceutical Co., Ltd.). The fan diameter of the fan-type formulation was 6 cm and the wind speed was 0.5 m / s.

[0104] [Example 10 and Comparative Example 8] Using fan-type formulations with samples 13 and 14, efficacy tests for inhibiting the establishment of creeping insects and knockdown tests were conducted. Specifically, the test was conducted under the same conditions as the fixation inhibition efficacy test and knockdown test in "Fixation Inhibition Evaluation 1," except that the fan of the fan-type formulation was used instead of the heat vaporizing agent. The fan of the fan-type formulation was positioned so that the airflow was directed towards the opening 20 of the partition plate 10 in the test chamber. The results are shown in Table 11.

[0105] [Table 11]

[0106] As shown in the results in Table 11, even when using a fan-type formulation, the airborne concentration of transfluthrin was 1 to 100 μg / m³. 3In Example 10, which used sample 13, although the test insects temporarily entered test space B, no phenomenon of colonization was observed. Based on these results, the airborne concentration of pyrethroid compounds, which are the active ingredients of the pest control composition, was determined to be 1 to 100 μg / m³ when using a fan-type formulation. 3 It has been shown that maintaining a space in this manner is highly effective in preventing the establishment of crawling insects within that space. Furthermore, the airborne concentration of transfluthrin is 0 μg / m³. 3 In Comparative Example 8, the colonization inhibition rate was 10.7%. This is thought to be due to the fact that the airflow from the fan-type formulation hit the vicinity of the opening 20 between test space A and test space B, which hindered the movement of the test insects into test space B.

[0107] Activity suppression assessment 1 The activity-inhibiting effect against cockroaches was evaluated using the following methods (1) to (3). The results are shown in Table 12. (1) For samples 2 and 5 shown in Table 12, heat-evaporated agents were prepared using samples 2 and 5 in the same manner as described above. (2) In an 8-tatami mat test room (3.6m long x 3.6m wide x 2.4m high), the heat vaporizing agents using samples 2 and 5 were set up as shown in Figure 2, and 5 adult male and female Oriental cockroaches were released as test insects. (3) Each heat-evaporating agent was energized for 4 hours to allow the control composition to be heated and vaporized into the test chamber. After energization, the presence or absence of insects wandering was visually confirmed for 1 minute, and the activity rate (%) was calculated using the following formula (III). Note that when the heat-evaporating agent using sample 2 was heated and vaporized, the airborne concentration of metofluthrin was 10 μg / m³ 3 That was the case. In this specification, wandering of test insects refers to the behavior of moving a certain distance in search of food or water. Furthermore, in equation (III) below, "number of test insects observed to be wandering in one minute" refers to the number of test insects that moved 10 cm or more during one minute of visual observation. Equation (III): Activity rate (%) = (Number of test insects observed exhibiting wandering behavior per minute / Number of survivors) × 100

[0108] [Table 12]

[0109] The results above confirm that using the heat-evaporating agent from sample 2 significantly reduced cockroach activity. Furthermore, no cockroach death or knockdown was observed. In this way, by maintaining the airborne concentration of pyrethroid compounds within a specific range, it was possible to reduce the activity of crawling insects without causing neuronal excitation, knockdown, or death due to the pyrethroid compounds.

[0110] Activity suppression assessment 2 The activity-inhibiting efficacy against mites was evaluated using the following methods (1) to (6). The results are shown in Table 14. (1) Each component was mixed according to the formulation shown in Table 13 to prepare samples 15 and 5, which are pest control compositions. For samples 15 and 5, heat-dispersible agents using samples 15 and 5 were prepared in the same manner as described above. (2) A humidity control tray (43.4 cm long x 31 cm wide x 14.3 cm high) was placed approximately 40 cm diagonally from the corner of a 4-tatami mat test room (1.8 m long x 3.6 m wide x 2.4 m high), and a 4 cm diameter petri dish containing approximately 500 house dust mites was placed inside the humidity control tray. The temperature and humidity of the test room were set to 26 ± 2°C and 60-80% RH, and the temperature and humidity inside the humidity control tray were set to 25°C and 75% RH. (3) Electricity was applied to each heat vaporizer to begin the heat vaporization of the control composition into the test chamber, and the petri dishes were collected after 7 days. The ventilation rate was 0.5 times / hour. In addition, the airborne concentration of transfluthrin when the heat vaporizer using sample 15 was heated vaporized was 14 μg / m³ 3 That was the case. (4) As a control, a 4 cm diameter petri dish containing approximately 500 house dust mites was placed in a humidity-controlled tray in the laboratory without the use of a heat vaporizer containing the sample, i.e., as an untreated group, and the petri dish was collected after 7 days in the same manner. The ventilation rate was set to 0.5 times / hour. (5) Ten house dust mites were placed in a 1 cm square enclosure from the collected petri dish, and a 30-second video was recorded using a microscope (Keyence Corporation). The enclosure was made using petroleum jelly. The recorded video was analyzed using tracking software (TPro, Pudith Sirigrivatanawong et al. Sensors 2017, 17(1), 96). (6) The above (5) was repeated three times, and the activity of 18 to 30 house dust mites that could be tracked was evaluated. The average mobility was then calculated from the mobility per minute of each house dust mite. The ratio (mobility ratio) of the average mobility when treated with the heat-evaporating agent using samples 15 and 5 to the average mobility of the untreated control group was also calculated.

[0111] [Table 13]

[0112] [Table 14]

[0113] The results above confirm that using the heat-evaporating agent from sample 15 significantly reduced mite activity. Furthermore, no mite death or knockdown was observed. In this way, by maintaining the airborne concentration of pyrethroid compounds within a space within a specific range, it was possible to reduce the movement, and therefore the activity, of crawling insects without causing neuronal excitation, knockdown, or death by pyrethroid compounds.

[0114] 《Evaluation of food consumption reduction 1》 The effectiveness of the food-inhibiting agent against cockroaches was evaluated using the following methods (1) to (3). The results are shown in Table 15. (1) Fifty adult male German cockroaches were released as test insects into an 8-tatami mat test room (3.6m long x 3.6m wide x 2.4m high). In addition, as shown in Figure 2, a heat vaporizing agent using sample 2 was placed in the test room. The test room with the heat vaporizing agent was designated as the treatment group, and for comparison, a test room without the heat vaporizing agent was also prepared as the untreated group. (2) In both the treated and untreated groups, German cockroaches were allowed to acclimate overnight in a fasting state, and then water 13 and solid food 14 were placed in the test chamber. In order to calibrate for weight changes due to moisture absorption, etc., a blank solid food (hereinafter referred to as blank, not shown) was placed in a location where the test insects could not eat it. (3) For the treated group, the control composition was heated and vaporized by applying an electric current to the heat vaporizing agent for 12 hours, and the weight of the solid feed 14 was measured after 12 hours, and the amount consumed (g) was calculated using the following formula (IV). The airborne concentration of metofluthrin in the treated group was 10 μg / m³ 3 The results were as follows. For the untreated group, the weight of solid feed 14 was measured 12 hours after the start of the experiment, and the amount consumed was calculated using the following formula (IV). Each experiment was conducted twice, and the average value was used as the amount consumed. Formula (IV): Amount consumed (g) = (Weight of blank after 12 hours / Initial weight of blank) × Initial weight of solid food - Weight of solid food after 12 hours

[0115] [Table 15]

[0116] From the results above, it was found that using the heat-evaporating agent from sample 2 reduced the amount consumed to approximately half of the amount consumed in the untreated area, demonstrating an inhibitory effect on cockroach consumption.

[0117] 《Evaluation of food consumption reduction 2》 The efficacy of the bait suppression agent against mites was evaluated using the following methods (1) to (6). The results are shown in Table 16. (1) Similar to (1) in "Activity Suppression Evaluation 2," each component was mixed according to the formulation shown in Table 13 to prepare control compositions, samples 15 and 5. For samples 15 and 5, heat-dispersible agents using samples 15 and 5 were prepared in the same manner as described above. (2) A humidity control tray was placed approximately 40 cm diagonally from the corner of a 4-tatami mat test room (1.8 m long x 3.6 m wide x 2.4 m high), and a 4 cm diameter petri dish containing approximately 500 house dust mites was placed inside the humidity control tray. (3) Each heat vaporizer was energized to begin the heat vaporization of the control composition into the test chamber, and the petri dishes were collected after 5 days. The ventilation rate was 0.5 times / hour. In addition, the airborne concentration of transfluthrin when the heat vaporizer using sample 15 was heated vaporized was 14 μg / m³ 3 That was the case. (4) As a control, a 4 cm diameter petri dish containing approximately 500 house dust mites was placed in a humidity-controlled tray in the laboratory without the use of a heat vaporizer containing the sample, i.e., as an untreated group, and the petri dish was collected after 5 days in the same manner. The ventilation rate was set to 0.5 times / hour. (5) The amount of allergen was quantified using a high-sensitivity ELISA kit for dust mite allergen (Derf1) (manufactured by ITEA Corporation). Derf1 is an allergen derived from the feces of the house dust mite. First, the inner wall of the petri dish was washed with 3 mL of phosphate buffer provided in the kit. The washing solution was filtered using gauze to remove impurities such as dust mite body fragments, and this was used as the test stock solution. ELISA was performed using this test stock solution to quantify the amount of allergen. (6) The total amount of allergen obtained (ng / mL) and the total number of mites tested were used to calculate the amount of allergen per 100 mites (ng / mL). In the calculation, it was assumed that the amount of food consumed and the amount of excreted by the mites tested were equal, and that all mites tested excreted equally. The consumption suppression rate was calculated from the allergen amount per 100 mites using the following formula (V). Formula (V): Feeding suppression rate (%) = {1 - (Excretion amount after 5 days / Excretion amount after 5 days in the control study)} × 100 ={1-(Increase in allergens after 5 days / Increase in allergens after 5 days in the control study)}×100

[0118] In determining the consumption suppression rate (%), it is ideal to directly measure the amount consumed. However, the amount consumed by mites is small, and directly measuring this amount is extremely difficult. Therefore, we decided to consider the amount of excretion as the amount consumed, but the amount of excretion is also small, and directly measuring this amount is extremely difficult. For this reason, as an alternative, we decided to measure the amount of allergen using an antigen-antibody reaction and indirectly evaluate the consumption suppression rate.

[0119] [Table 16]

[0120] 《Proliferation Inhibition Evaluation 1》 The efficacy in inhibiting the proliferation of cockroaches was evaluated using the following methods (1) to (3). (1) Similar to the evaluation of food consumption inhibition, 40 final-instar nymphs of German cockroaches were released as test insects into an 8-tatami mat test room (3.6m long x 3.6m wide x 2.4m high). The ratio of males to females among the adult cockroaches that emerged was similar in the untreated and treated groups. In addition, as shown in Figure 2, a heat vaporizing agent using sample 2 was placed in the test room. The test room with this heat vaporizing agent was designated as the treated group, and for comparison, a test room without the heat vaporizing agent was also prepared as the untreated group. (2) After allowing the German cockroaches to acclimate overnight, water 13 and solid food 14 were placed in the test room. (3) In the treated areas, the heat vaporizing agent was applied for 24 hours a day for 47 consecutive days, and the number of surviving insects was measured over time. In addition, the egg-carrying rate and number of eggs laid by the insects were measured up to 20 days after the application of the power. The airborne concentration of metofluthrin in the treated areas was 10 μg / m³ 3 In the untreated group, the number of surviving insects was measured over time for 47 days from the start of the experiment, and the egg-laying rate and number of eggs laid were measured up to day 20. The egg-carrying rate is the percentage of adult females carrying eggs out of the total number of surviving adult females. The number of eggs laid is the number of egg cases laid in the laboratory.

[0121] Figure 3 shows the change in the number of survivors over time, Figure 4 shows the change in the incubation rate over time, and Figure 5 shows the change in the number of eggs laid over time. Figures 4 and 5 show that the egg-laying rate was lower in the treated area compared to the untreated area, and no egg-laying was observed. In Figure 5, although the results for the treated area are difficult to see, it indicates that the number of eggs laid was 0 for all 20 days of the experiment. Therefore, as shown in Figure 3, in the untreated area, larvae hatched from laid eggs and the number of survivors increased, while in the treated area, the number of individuals for the next generation did not increase. As a result, it was confirmed that using the heat-evaporating agent from sample 2 suppressed the proliferation of cockroaches. This is thought to be because the activity level of the cockroaches was suppressed, resulting in decreased appetite and an increase in natural deaths, as well as a lack of energy for egg-laying and incubation. Furthermore, the decrease in the incubation rate suggests that not only was energy for incubation unavailable, but the reproductive activities of the cockroaches (mating behavior, courtship behavior, etc.) were also suppressed.

[0122] 《Proliferation Inhibition Evaluation 2》 The inhibitory effect on mite proliferation was evaluated using the following methods (1) to (6). The results are shown in Table 17. (1) Each component was mixed according to the formulation shown in Table 13 to prepare samples 15 and 5, which are pest control compositions. For samples 15 and 5, heat-dispersible agents using samples 15 and 5 were prepared in the same manner as described above. (2) A humidity control tray was placed approximately 40 cm diagonally from the corner of a 4-tatami mat test room (1.8 m long x 3.6 m wide x 2.4 m high), and a 4 cm diameter petri dish containing 30 adult female house dust mites was placed inside the humidity control tray. (3) Electricity was applied to each heat vaporizer to begin the heat vaporization of the control composition into the test chamber, and the petri dishes were collected after 14 days. The ventilation rate was 0.5 times / hour. In addition, the airborne concentration of transfluthrin when the heat vaporizer using sample 15 was heated vaporized was 14 μg / m³3 That was the case. (4) As a control, a 4 cm diameter petri dish containing 30 adult female house dust mites was placed in a humidity-controlled tray in a laboratory without the use of a heat vaporizer containing the sample, i.e., an untreated group. The petri dish was collected after 14 days. The ventilation rate was set to 0.5 times / hour. (5) The collected petri dishes were washed, and the number of house dust mite larvae and eggs was counted using a stereomicroscope (manufactured by Olympus Corporation), and the total number was taken as the total number of eggs laid. (6) The above steps (2) to (5) were repeated twice, and the average total number of eggs laid was calculated. The average total number of eggs laid after 14 days in the control group (untreated group) was also calculated, and the spawning suppression rate was calculated using the following formula (VI). Equation (VI): Spawn suppression rate (%) = [{(Average total number of eggs laid in the untreated area) - (Average total number of eggs laid when the heat vaporizer was installed)} / (Average total number of eggs laid in the untreated area)] × 100

[0123] [Table 17]

[0124] The results above confirm that using the heat-evaporating agent from sample 15 significantly suppressed mite oviposition, i.e., proliferation. Thus, by maintaining the airborne concentration of pyrethroid compounds within a specific range, it was possible to suppress the proliferation of crawling insects.

[0125] In addition to the above, the same establishment inhibition evaluation as for cockroaches was conducted on the creeping insect house dust mite, and it was confirmed that the treatment effectively inhibits establishment.

[0126] Although the present invention has been described in detail and with reference to specific embodiments, it will be apparent to those skilled in the art that various changes and modifications can be made without departing from the spirit and scope of the invention. This application is based on Japanese Patent Application No. 2023-013304 filed on 31 January 2023 and Japanese Patent Application No. 2023-078173 filed on 10 May 2023, the contents of which are incorporated herein by reference. [Explanation of Symbols]

[0127] 10 partition plates 11 Heat-dispersing agent 12 Shelters 13 water 14. Solid feed 20 openings

Claims

1. A method for controlling creeping insects, comprising heating and vaporizing a control composition containing a pyrethroid compound, The pyrethroid compound includes at least one of metofluthrin and transfluthrin. By heating and evaporating the aforementioned pest control composition into the space, the airborne concentration of the pyrethroid compound in the space is reduced to 1 to 100 μg / m³. ３ A method for controlling crawling insects, characterized by maintaining them within a certain range and preventing the crawling insects from settling into the space.

2. The method for controlling creeping insects according to Claim 1, wherein the content of the pyrethroid compound in the control composition is 0.2 to 16 w / v%.

3. The method for controlling creeping insects according to claim 1 or 2, wherein the ventilation conditions of the space in which the pest control composition is heated and vaporized are 0.1 to 20 times / hour.

4. The method for controlling creeping insects according to claim 1 or 2, wherein the airborne concentration of the pyrethroid compound in the space is maintained within the range of 1 to 80 μg / m³ by heating and vaporizing the control composition into the space.

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