Medicines for the prevention or treatment of kidney damage, non-infectious inflammation, and vascular disease.

A pharmaceutical product using blood coagulation factor Xa inhibitors and bisphosphonate preparations addresses the formation of calciprotein particles, reducing inflammation and fibrosis in the kidneys and suppressing vascular calcification, providing effective treatment for chronic kidney disease and vascular diseases.

JP7874348B2Active Publication Date: 2026-06-16JICHI MEDICAL UNIVERSITY
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Patent Information

Authority / Receiving Office
JP · JP
Patent Type
Patents
Current Assignee / Owner
JICHI MEDICAL UNIVERSITY
Filing Date
2025-01-08
Publication Date
2026-06-16

AI Technical Summary

Technical Problem

Current treatments are inadequate for preventing or treating diseases, symptoms, or disorders related to the formation of calciprotein particles, which contribute to chronic kidney disease, non-infectious inflammation, and vascular diseases.

Method used

A pharmaceutical product containing blood coagulation factor Xa inhibitors and bisphosphonate preparations, or their pharmaceutically acceptable salts or solvates, is administered to inhibit the binding of Toll-like receptors to calciprotein particles, thereby reducing inflammation and fibrosis in the kidneys and suppressing vascular calcification.

Benefits of technology

The product effectively prevents or treats renal impairment, non-infectious inflammation, and vascular diseases by suppressing the pathogenic activity of calciprotein particles, as demonstrated by reduced markers of inflammation and fibrosis in animal models and patient samples.

✦ Generated by Eureka AI based on patent content.

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Abstract

To provide means that can prevent or treat a disease, symptom or disorder involved in the formation of calciprotein particles.SOLUTION: One embodiment of the present invention relates to a pharmaceutical for preventing or treating nephropathy, noninfective inflammation and vascular disease, comprising a bisphosphonate preparation or a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable solvate thereof, as an active ingredient.SELECTED DRAWING: None
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