Polyalkylene alkyl compounds for defoaming fermentation broth

JP7874721B2Active Publication Date: 2026-06-16DOW GLOBAL TECHNOLOGIES LLC
View PDF 9 Cites 0 Cited by

Patent Information

Authority / Receiving Office
JP · JP
Patent Type
Patents
Current Assignee / Owner
DOW GLOBAL TECHNOLOGIES LLC
Filing Date
2021-09-29
Publication Date
2026-06-16

Smart Images

  • Figure 0007874721000001
    Figure 0007874721000001
  • Figure 0007874721000002
    Figure 0007874721000002
  • Figure 0007874721000003
    Figure 0007874721000003
Patent Text Reader

Abstract

The present invention relates to a method for inhibiting foam formation in a process comprising the step of adding to the process mixture an effective amount of a foam control agent, the foam control agent having the formula RO(EO) n (PO) m H, where R is a straight chain hydrocarbon radical having 12 to 18 carbon atoms, EO is ethylene oxide, PO is propylene oxide, n can be any integer from 2 to 9, and m can be any integer from 8 to 19. The compounds may further be characterized in that the molecular weight of R is 8 to 29 percent by weight of the compound. These compositions have been found to be superior in controlling foam formation over conventional defoamers in fermentations, preferably amino acid fermentations and enzymatic fermentations, more preferably lysine, MSG, and glucose oxidase fermentations.
Need to check novelty before this filing date? Find Prior Art

Claims

1. A method for inhibiting foam formation in a process comprising the step of adding an effective amount of foam control agent to a fermentation broth, wherein the foam control agent is of the formula 2) ｎ ( ) ｍ H The compound includes compounds that can be represented by the formula (wherein R is a linear hydrocarbon radical having 12 to 18 carbon atoms, EO is ethylene oxide, PO is propylene oxide, n is any integer from 2 to 9, and m is any integer from 8 to 19), A method characterized in that the compound further has a molecular weight of R of 8 to 29 weight percent of the compound.

2. The method according to claim 1, wherein R has 16 to 18 carbon atoms.

3. The method according to claim 1, wherein the foam control agent has a molecular weight of 712 to 1800.

4. The method according to claim 1, wherein the foam control agent has a cloud point of 10 to 30°C.

5. The method according to claim 1, wherein the process includes fermentation.

6. The method according to claim 1, wherein the fermented broth contains one or more of lysine, MSG, and glucose oxidase.

7. The method according to claim 1, wherein the foam control agent is added to the fermentation broth in an amount of 1 to 5,000 ppm by weight.

8. The method according to claim 1, wherein n is 4 to 7.

9. The method according to claim 1, wherein m is 12 to 15.

10. The method according to claim 1, wherein the molecular weight of R is 18 to 23 weight percent of the foam control agent.

11. A defoaming agent formulation for fermentation broth comprising a foam control agent, water, and one or more of seed oil, mineral oil, wax, surfactant, and silicone, wherein the foam control agent is of the formula 2) ｎ ( ) ｍ H The compound comprises (wherein R is a linear hydrocarbon radical having 12 to 18 carbon atoms, EO is ethylene oxide, PO is propylene oxide, n is any integer from 2 to 9, and m is any integer from 8 to 19), The aforementioned compound is further characterized in that the molecular weight of R is 8 to 29 weight percent of the aforementioned compound, wherein the antifoaming agent formulation for fermentation broth.