Chimeric antigen receptors targeting BCMA and their applications
JP7875609B2Active Publication Date: 2026-06-18SHANGHAI ORIGINCELL MEDICAL TECHNOLOGY CO LTD
Patent Information
- Authority / Receiving Office
- JP · JP
- Patent Type
- Patents
- Current Assignee / Owner
- SHANGHAI ORIGINCELL MEDICAL TECHNOLOGY CO LTD
- Filing Date
- 2022-04-26
- Publication Date
- 2026-06-18
AI Technical Summary
⚠Technical Problem
Current CAR-T therapy products do not effectively target BCMA, limiting their efficacy in treating B-cell malignancies such as multiple myeloma.
⚗Method used
Development of a chimeric antigen receptor (CAR) that specifically binds to BCMA, comprising defined antibody sequences for high toxicity, cytokine secretion, and tumor suppression capabilities, expressed on immune effector cells.
🎯Benefits of technology
The CAR-T cells demonstrate high lethal toxicity to BCMA-positive cells, significant cytokine secretion, enhanced proliferation, and effective tumor suppression, offering a promising therapeutic approach for BCMA-associated diseases.
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Smart Images
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Abstract
An object of the present invention is to provide a high pressure fuel pump roller tappet. The present invention relates to a chimeric antigen receptor (CAR) targeting BCMA and applications thereof, the CAR comprising a BCMA-binding domain, the BCMA-binding domain comprising an antibody or antigen-binding fragment thereof that specifically binds to BCMA, the antibody comprising a light chain complementarity determining region 3 (HCDR3), and the HCDR3 comprising the amino acid sequence shown in SEQ ID NO: 25. Immune effector cells and pharmaceutical compositions comprising the CAR, and methods of treating diseases or disorders associated with BCMA expression.
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