Method for producing non-human primate model of cerebral infarction and pharmaceutical composition for treating cerebral infarction
Patent Information
- Authority / Receiving Office
- JP · JP
- Patent Type
- Applications
- Filing Date
- 2023-06-29
- Publication Date
- 2026-07-06
AI Technical Summary
Current cerebral infarction models, particularly in non-human primates, are inadequate for evaluating therapeutic agents in subacute to chronic stages due to limited durability of motor dysfunction and difficulty in inducing consistent damage in perforator-innervated regions, leading to a lack of effective treatments for these stages.
A non-human primate animal model is created by administering endothelin to the basal ganglia and thalamic regions to induce basal ganglia, thalamic, and internal capsule damage, which is maintained over a long period, and NeuroD1 is used as a therapeutic agent to promote nerve regeneration.
The model allows for the evaluation of therapeutic agents in subacute to chronic cerebral infarction and perforator infarction, demonstrating prolonged motor dysfunction and potential for functional recovery through NeuroD1-induced nerve regeneration.