Heat stress relief agent

Abstract

To provide a heat stress alleviator.SOLUTION: A heat stress alleviator includes at least one or more types of maltobionic acid selected from the group consisting of maltobionic acid expressed by a general formula of 4-O-α-D-glucopyranosyl-D-gluconic acid and salt thereof. The salt may include at least one or more types selected from maltobionic acid sodium, maltobionic acid calcium, maltobionic acid magnesium, maltobionic acid potassium, maltobionic acid copper, maltobionic acid iron, and maltobionic acid zinc.SELECTED DRAWING: None

Description

【Technical Field】 【0001】 The present invention relates to a heat stress reliever. 【Background Art】 【0002】 In recent years, against the backdrop of global warming due to the increasing emissions of greenhouse gases associated with human life activities, the occurrence of heatstroke during exercise (sports activities), labor, etc. and in daily life has been frequently observed. Heatstroke is defined as "a general term for conditions caused by disorders of physical adaptation in a hot environment", and its symptoms are classified into heat syncope, heat fatigue, heat convulsion, and heatstroke. 【0003】 In particular, the increase in heatstroke among heatstroke vulnerable groups, such as infants and young children whose bodies are small, have a low heat capacity, and are easily affected by the thermal conditions of the environment, and the elderly whose sensitivity to environmental temperature and body temperature regulation function decline due to aging, has become a social problem, and effective and efficient countermeasures against heat stress are required. 【0004】 From these viewpoints, as preventive measures against heatstroke caused by heat stress, efficient water replenishment by frequent water intake and salt intake is recommended, and beverage compositions containing a mixture of glycerin and water, high-concentration sodium, etc. have been proposed (see Patent Documents 1 and 2). In addition, there is a report that a beverage containing egg white peptides obtained by hydrolyzing egg white is effective in suppressing the rise in deep body temperature under heat stress (see Patent Document 3). 【0005】 As described above, although development proposals regarding preventive measures against heatstroke caused by heat stress are being made, the reality is that further development is desired. 【Prior Art Documents】 【Patent Documents】 【0006】 【Patent Document 1】 Japanese Patent Application Laid-Open No. 2004-123686 【Patent Document 2】 Japanese Patent Publication No. 2015-211652 [Patent Document 3] Japanese Patent Publication No. 2008-072968 [Overview of the Initiative] [Problems that the invention aims to solve] 【0007】 This invention has been made in view of the above circumstances, and aims to provide a novel heat stress mitigating agent. [Means for solving the problem] 【0008】 The inventors have surprisingly discovered that maltobionic acid and its salts can promote sweating, suppress the rise in core body temperature, and alleviate heat stress, thus completing the present invention. Specifically, the present invention provides the following: 【0009】 (1) A heat stress reliever comprising at least one maltobionic acid selected from the group consisting of maltobionic acid represented by the general formula 4-O-α-D-glucopyranosyl-D-gluconic acid and its salts. 【0010】 (2) The heat stress reliever according to (1), wherein the salts are at least one selected from calcium maltobionate, magnesium maltobionate, sodium maltobionate, potassium maltobionate, copper maltobionate, iron maltobionate, and zinc maltobionate. 【0011】 (3) A heat stress reliever described in (1) or (2), which is a food or beverage. 【0012】 (4) A heat stress reliever as described in (1) or (2), which is a heat fatigue reducer. [Effects of the Invention] 【0013】 According to the present invention, it is possible to provide a heat stress reliever that can alleviate heat stress. [Modes for carrying out the invention] 【0014】 The heat stress relief method of the present invention comprises at least one maltobionic acid selected from the group consisting of maltobionic acid represented by the general formula 4-O-α-D-glucopyranosyl-D-gluconic acid and its salts. 【0015】 The heat stress mitigating agent of the present invention contains maltobionic acids as an active ingredient, and as shown in the examples described later, it can significantly promote sweating in a heat stress environment and significantly suppress the rise in core body temperature in a heat stress environment. Furthermore, by promoting sweating and suppressing the rise in core body temperature, heat fatigue can be reduced. Therefore, the heat stress mitigating agent of the present invention can be used, for example, as an oral composition in foods, animal feed, pharmaceuticals, etc., for the prevention or improvement of heatstroke and performance decline. The heat stress mitigating agent of the present invention can be used, for example, as an agent to suppress the rise in core body temperature, an agent to promote sweating, or an agent to reduce heat fatigue. In this specification, heat stress refers to the stimuli (load) that exercise, work, and daily life impart to the bodies of humans, livestock, and other animals in high-temperature environments such as summer or factories, and a heat stress environment refers to a situation in which one is exposed to heat stress. 【0016】 The mechanism by which maltobionic acid, represented by the general formula 4-O-α-D-glucopyranosyl-D-gluconic acid, and its salts promote sweating and suppress the rise in core body temperature is thought to be as follows: 【0017】 Generally, frequent hydration is considered an effective way to alleviate heat stress, but it is also recommended to replenish minerals such as sodium, potassium, magnesium, and calcium that are lost along with water during sweating. In particular, among minerals, divalent cations such as calcium and magnesium play a role in thermoregulation in the body, but are known to be difficult to maintain in a soluble state in the intestinal tract and have poor absorption. 【0018】 Maltobionic acid represented by the general formula of 4-O-α-D-glucopyranosyl-D-gluconic acid and its salts have the function of promoting the efficient absorption of divalent cations such as calcium and magnesium into the body by maintaining the solubilized state of minerals in the intestinal tract. Therefore, it is considered that when divalent cations are continuously absorbed into the body, the nerve transmission related to body temperature regulation maintains normal function, sweating is promoted, and the rise in deep body temperature is suppressed. 【0019】 The maltobionic acids contained in the heat stress reliever are maltobionic acid represented by the general formula of 4-O-α-D-glucopyranosyl-D-gluconic acid and its salts. The heat stress reliever may contain both maltobionic acid and its salts. Examples of the salt form include calcium salts, magnesium salts, sodium salts, iron salts, potassium salts, zinc salts, copper salts, etc. There is no limitation on the form of the maltobionic acids contained in the heat stress reliever, and it may be in liquid form, powder form, or even in the form of a solid obtained by powdering liquid maltobionic acids together with an excipient. 【0020】 The content of maltobionic acids can be appropriately set according to the type and form of the heat stress reliever. For example, for the heat stress reliever, it is 0.001% to 100% by mass, preferably 0.01% to 50% by mass, more preferably 0.05% to 30% by mass, and particularly preferably 0.1% to 30% by mass. For example, when the heat stress reliever is a solid such as a tablet, the content of maltobionic acids is preferably 0.01% to 50% by mass, more preferably 5% to 30% by mass, based on the heat stress reliever (solid). Also, when the heat stress reliever is in the form of a beverage such as a soft drink, the content of maltobionic acids is preferably 0.01% to 30% by mass, more preferably 0.1% to 5% by mass, based on the heat stress reliever (beverage). 【0021】 The heat stress reliever of the present invention may contain only maltobionic acids or may contain maltobionic acids and other components. Examples of the other components include functional components, nutritional supplements, saccharides, sweeteners, acidulants, colorants, thickeners, brighteners, and manufacturing agents. In addition to these, various excipients, binders, lubricants, stabilizers, diluents such as water, bulking agents, thickeners, emulsifiers, colorants, fragrances, additives, seasonings, and other components conventionally contained in food and beverages can be used as the other components. The content of the other components can be appropriately selected according to the form of the heat stress reliever of the present invention. When the heat stress reliever further contains other heat stress relieving components different from maltobionic acids, the content of maltobionic acids may be reduced. 【0022】 The form of the heat stress reliever of the present invention (for example, food and beverage products, deep body temperature rise inhibitors, sweating promoters, heat fatigue reducers) is not particularly limited, but for example, it can be an oral heat stress reliever. The form of the oral heat stress reliever is not particularly limited and can be any form. For example, forms suitable for oral intake, specifically, liquid, powder, granular, granule, tablet, bar, plate, block, solid, round, candy, paste, cream, capsule like hard capsule or soft capsule, caplet, tablet, gel, jelly, gummy, wafer, biscuit, cookie, chewable, syrup, stick, and other forms can be mentioned. 【0023】 The method of using the heat stress reliever of the present invention is not particularly limited. For example, in the case of a liquid heat stress reliever, it can be orally ingested by drinking it as it is or diluted with water or the like. In addition, the heat stress reliever is used, for example, by oral administration. The subjects of oral administration are, for example, animals such as humans and livestock. 【0024】 The amount of heat stress mitigating agent to be taken is not particularly limited and can be appropriately set according to the condition of the person taking it (e.g., human or livestock) (e.g., age, degree of heat stress exposure) and the manner of intake. However, the daily intake for adults is, for example, 5 to 400 mg / kg, preferably 10 to 200 mg / kg, and more preferably 20 to 100 mg / kg, based on the weight of the person taking it, in terms of the mass of maltobionic acids. 【0025】 The heat stress mitigating agent of the present invention may be food or beverage (including health-oriented food and beverage, for example, nutritional supplements, health supplements, nutritional adjustment foods, health functional foods, foods for specified health uses, nutrient function foods, foods with functional claims, etc.), animal feed, or pharmaceutical composition (pharmaceuticals, quasi-drugs, etc.). [Examples] 【0026】 The present invention will be described in more detail below with reference to examples, but the present invention is not limited to these examples, and can take various forms as long as it can solve the problems of the present invention. 【0027】 <Example 1 and Comparative Example 1> Heat stress relief agent in the form of a soft drink (1) Verification of the effect of maltobionic acid intake on suppressing the rise in core body temperature and promoting sweating. The effects of maltobionic acid on suppressing core body temperature rise and promoting sweating were investigated by having subjects ingest either a test sample containing maltobionic acid or a placebo sample, and measuring core body temperature and sweat volume under heat stress conditions (room temperature 30°C, humidity 60% and exercise load conditions). 【0028】 (2) Preparation of test samples Samples for Comparative Example 1 (placebo sample) and Example 1 (test sample) were prepared by mixing mineral water (manufactured by Suntory Foods Limited), maltose syrup (manufactured by San-ei Sugar Refining Co., Ltd.), and maltobionic acid (manufactured by San-ei Sugar Refining Co., Ltd.) according to the formulations (amount (g)) shown in Table 1. 【0029】 [Table 1] 【0030】 (3) Verification of the effect of maltobionic acid intake on suppressing the rise in core body temperature Nine healthy adult males (aged 24-51) were used as subjects. They were dressed in commercially available long-sleeved shirts made of the same material (manufactured by Gunze Corporation). They were then given either a placebo or a test sample without being informed whether they were receiving the test sample or a placebo. After resting for 15 minutes following ingestion, they performed a 30-minute exercise load using step-up exercises (stepping up and down a 30cm high step 20 times per minute) in an environment of 30°C and 60% relative humidity. The study was a crossover single-dose blind study, where subjects who first received the placebo sample received the test sample, and subjects who first received the test sample received the placebo sample, and the study was conducted similarly. 【0031】 (4) Evaluation items and evaluation methods The evaluation indicators were changes in core body temperature and sweat volume under heat stress conditions (exercise load from step-up exercise at room temperature of 30°C and relative humidity of 60%). Core body temperature was measured using a wireless tympanic thermometer with a non-contact infrared sensor (TechnoNext Co., Ltd., BL100). Sweat volume was calculated by subtracting the weight of the long-sleeved shirt before exercise from the weight of the long-sleeved shirt after exercise. 【0032】 (5) Statistical processing methods All results are expressed as mean ± standard error. Significant differences between the two groups were determined using Student's t-test at a 5% significance level. 【0033】 (6) Changes in core body temperature rise Table 2 shows the changes in core body temperature after sample intake. Compared to the placebo sample (Comparative Example 1), a significant suppression of the rise in core body temperature was observed in the test sample (Example 1) from 12 minutes after exercise. 【0034】 [Table 2] 【0035】 (6) Comparison of sweat volume Table 3 shows the results of sweat volume after sample ingestion. Compared to Comparative Example 1, a significant increase in sweat volume was observed in Example 1. 【0036】 [Table 3] 【0037】 <Example 2 and Comparative Example 2> Heat stress relief agent in the form of a soft drink (1) Verification of the effect of calcium maltobionate intake on suppressing the rise in core body temperature and promoting sweating. The effects of calcium maltobionate on suppressing core body temperature rise and promoting sweating were verified under the same test conditions as in Example 1 and Comparative Example 1. 【0038】 (2) Preparation of test samples Samples for Comparative Example 2 (placebo sample) and Example 2 (test sample) were prepared by mixing mineral water (manufactured by Suntory Foods Limited), maltose (manufactured by Hayashibara Co., Ltd.), calcium carbonate (manufactured by Sankyo Flour Milling Co., Ltd.), and calcium maltobionate (manufactured by San-ei Sugar Refining Co., Ltd.) according to the formulations (amount (g)) shown in Table 4. 【0039】 [Table 4] 【0040】 (3) Calcium maltobionate intake test Nine healthy adult males (aged 24-51) were used as subjects. They were dressed in commercially available long-sleeved shirts made of the same material (manufactured by Gunze Corporation). They were then given either a placebo or a test sample without being informed whether they were receiving the test sample or a placebo. After resting for 15 minutes following ingestion, they performed a 30-minute exercise load using step-up exercises (stepping up and down a 30cm high step 20 times per minute) in an environment of 30°C and 60% relative humidity. The study was a crossover single-dose blind study, where subjects who first received the placebo sample received the test sample, and subjects who first received the test sample received the placebo sample, and the study was conducted similarly. 【0041】 (4) Evaluation items and evaluation methods The evaluation indicators were changes in core body temperature and sweat volume under heat stress conditions (exercise load from step-up exercise at room temperature of 30°C and relative humidity of 60%). Core body temperature was measured using a wireless tympanic thermometer with a non-contact infrared sensor (TechnoNext Co., Ltd., BL100). Sweat volume was calculated by subtracting the weight of the long-sleeved shirt before exercise from the weight of the long-sleeved shirt after exercise. 【0042】 (5) Statistical processing methods All results are expressed as mean ± standard error. Significant differences between the two groups were determined using Student's t-test at a 5% significance level. 【0043】 (6) Changes in core body temperature rise Table 5 shows the changes in core body temperature after sample ingestion. Compared to Comparative Example 2, a significant suppression of the rise in core body temperature was observed in Example 2 from 13 minutes after exercise load. 【0044】 [Table 5] 【0045】 (6) Comparison of sweat volume Table 6 shows the results of sweat volume after sample ingestion. Compared to Comparative Example 2, a significant increase in sweat volume was observed in Example 2. 【0046】 [Table 6] 【0047】 Furthermore, as shown in Tables 1-6, the samples of Examples 1-2 containing maltobionic acids have the effect of suppressing the rise in core body temperature and promoting sweating, and therefore can be said to reduce heat fatigue. 【0048】 <Example 3> Heat stress relief agent in tablet form 50 parts by mass of calcium maltobionate (manufactured by San-ei Sugar Refining Co., Ltd.), 45 parts by mass of total glucose (manufactured by San-ei Sugar Refining Co., Ltd., a white spherical powder obtained by spray-drying liquid glucose), 3 parts by mass of citric acid, 1.5 parts by mass of calcium stearate, and 0.5 parts by mass of silicon dioxide were uniformly mixed and compressed into tablets according to a standard method to obtain a heat stress reliever in tablet form of 1000 mg per tablet. The obtained tablet form of the heat stress reliever was measured in the same manner as in Example 2, with changes in core body temperature and sweat volume under a heat stress environment (exercise load by step-up exercise at room temperature of 30°C and relative humidity of 60%). The results showed that it exhibited a core body temperature rise suppression effect and a sweat promotion effect, and was also a heat stress reliever with good flavor and taste. Furthermore, the heat stress reliever of Example 3 containing calcium maltobionate has a core body temperature rise suppression effect and a sweat promotion effect, and can be said to reduce heat fatigue. 【0049】 <Example 4> Heat stress relief agent in the form of a soft drink 0.05 parts by mass of calcium maltobionate (manufactured by San-ei Sugar Refining Co., Ltd.), 10 parts by mass of sugar, 0.15 parts by mass of citric acid, and 89.8 parts by mass of mineral water were uniformly dissolved to obtain a 500 mL soft drink-type heat stress reliever. The obtained soft drink-type heat stress reliever was used in the same manner as in Example 2, and the change in core body temperature and the amount of sweat produced were measured under a heat stress environment (exercise load by step-up exercise at room temperature of 30°C and relative humidity of 60%). The results showed that it exhibited a core body temperature rise suppression effect and a sweat promotion effect, and was a heat stress reliever with good flavor and taste. Furthermore, the heat stress reliever of Example 4, which contains calcium maltobionate, has a core body temperature rise suppression effect and a sweat promotion effect, and can be said to reduce heat fatigue. [Industrial applicability] 【0050】 The heat stress mitigating agent of the present invention can promote sweating and suppress the rise in core body temperature, and is useful, for example, in preventing and improving the onset of heatstroke and the decline in performance during work or exercise in a heat stress environment.

Claims

[Claim 1] An agent for mitigating heat stress, comprising at least one maltobionic acid selected from the group consisting of maltobionic acid represented by the general formula 4-O-α-D-glucopyranosyl-D-gluconic acid and its salts. [Claim 2] The agent for mitigating heat stress according to claim 1, wherein the salts are at least one selected from sodium maltobionate, calcium maltobionate, magnesium maltobionate, potassium maltobionate, copper maltobionate, iron maltobionate, and zinc maltobionate. [Claim 3] An agent for suppressing the rise in core body temperature or promoting sweating, comprising at least one maltobionic acid selected from the group consisting of maltobionic acid represented by the general formula 4-O-α-D-glucopyranosyl-D-gluconic acid and its salts. [Claim 4] The agent for suppressing rise in core body temperature or promoting sweating according to claim 3, wherein the salts are at least one selected from sodium maltobionate, calcium maltobionate, magnesium maltobionate, potassium maltobionate, copper maltobionate, iron maltobionate, and zinc maltobionate. [Claim 5] The agent according to any one of claims 1, 2, 3, or 4, which is a food or beverage. [Claim 6] The agent according to any one of claims 1, 2, 3, or 4, which is an agent for reducing heat fatigue that can be reduced by promoting sweating and suppressing the rise in core body temperature.

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