A composition containing two types of polyglycerin fatty acid esters and skincare active ingredients.

Abstract

To provide a composition containing at least two kinds of different types of polyglyceryl fatty acid ester, which is in the form of nano or microemulsion even in the case of containing skin-care active ingredient.SOLUTION: A composition in the form of nano or microemulsion contains: (a) at least one kind of optionally selected oil; (b) at least one kind of first polyglyceryl fatty acid ester having an HLB value of 13.0 or more, preferably 13.5 or more, more preferably 14.0 or more; (c) at least one kind of second polyglyceryl fatty acid ester having an HLB value of 10.0 or less, preferably 9.0 or less, more preferably 8.0 or less; (d) at least one kind of skin-care active ingredient; and (e) water, where the mass ratio of (b) the amount of first polyglyceryl fatty acid ester / (c) the amount of second polyglyceryl fatty acid ester is 3.0 or more, preferably 4.0 or more, even more preferably 5.0 or more, the mass ratio of (a) the amount of oil / the total amount of (b) the first polyglyceryl fatty acid ester and (c) the second polyglyceryl fatty acid ester is 0.5 or less, and the composition includes 0.1 mass% or less of anionic surfactant, preferably 0.01 mass% or less of anionic surfactant, more preferably does not include anionic surfactant. The composition according to the present invention can be in the form of nano or microemulsion despite that it includes at least two kinds of different types of polyglyceryl fatty acid ester and at least one kind of skin-care active ingredient.SELECTED DRAWING: None

Description

[Technical Field]

[0001] The present invention relates to a composition comprising at least two polyglycerin fatty acid esters and at least one skincare active ingredient, preferably a cosmetic composition or a dermatological composition. [Background technology]

[0002] Oil-in-water (O / W) emulsions and water-in-oil (W / O) emulsions are well known in the fields of cosmetics and dermatology, particularly for the preparation of cosmetic products such as lotions, creams, tonics, serums, and lotions.

[0003] In particular, fine emulsions such as O / W type nano or microemulsions are especially attractive in cosmetics due to their transparent or slightly translucent appearance.

[0004] On the other hand, compositions containing polyglycerol fatty acid esters are well known in the fields of cosmetics and dermatology. Polyglycerol fatty acid esters can function as surfactants and are therefore typically used to prepare emulsions such as oil-in-water (O / W) or water-in-oil (W / O) emulsions. Compared to polyoxyethylene-based surfactants, polyglycerol fatty acid esters are preferred for environmental reasons, such as their lower environmental impact.

[0005] WO 2020 / 110716 discloses compositions in the form of nano or microemulsions comprising at least two different types of polyglycerol fatty acid esters. [Prior art documents] [Patent Documents]

[0006] [Patent Document 1] WO 2020 / 110716 [Patent Document 2] EP-A-0 487 404 [Patent Document 3] EP-A-0 425 066 [Patent Document 4] Japanese Unexamined Patent Application Publication No. 05-213736 [Patent Document 5] EP 0 667 145 [Patent Document 6] EP 1 430 883 [Patent Document 7] WO 02 / 051 828 [Non-Patent Document]

[0007] [Non-Patent Document 1] Written by Walter Noll, Chemistry and Technology of Silicones (1968), Academic Press [Non-Patent Document 2] Cosmetics and Toiletries, Vol. 91, Jan. 76, pp. 27 - 32, Todd & Byers, Volatile Silicone Fluids for Cosmetics [Non-Patent Document 3] Article by Meylan and Howard: Atom / Fragment contribution method for estimating octanol - water partition coefficients, J. Pharm. Sci., 84: pp. 83 - 92, 1995 [Non-Patent Document 4] Exploring QSAR: hydrophobic, electronic and steric constants (ACS professional reference book, 1995) [Non-Patent Document 5] http: / / esc.syrres.com / interkow / kowdemo.htm [Non-Patent Document 6] Satoshi Tomomasa et al., Oil Chemistry, Vol. 37, No. 11 (1988), pp. 48 - 53 [Summary of the Invention]

Problems to be Solved by the Invention

[0008] However, the compositions disclosed in WO 2020 / 110716 are unstable, and it has been found that when skin care active ingredients such as lactic acid and niacinamide are added to the composition, they can no longer be in the form of nano- or micro-emulsions.

[0009] An object of the present invention is to provide a composition containing at least two different types of polyglycerol fatty acid esters, which is in the form of nano- or micro-emulsion even when it also contains skin care active ingredients.

Means for Solving the Problems

[0010] The above object of the present invention is (a) at least one optional oil, and (b) at least one first polyglycerol fatty acid ester having an HLB value of 13.0 or more, preferably 13.5 or more, more preferably 14.0 or more, (c) at least one second polyglycerol fatty acid ester having an HLB value of 10.0 or less, preferably 9.0 or less, more preferably 8.0 or less, (d) at least one skin care active ingredient, and (e) water to form a composition in the form of nano- or micro-emulsion, where the mass ratio of the amount of (b) the first polyglycerol fatty acid ester / the amount of (c) the second polyglycerol fatty acid ester is 3.0 or more, preferably 4.0 or more, even more preferably 5.0 or more, and the mass ratio of the amount of (a) oil / the total amount of (b) the first polyglycerol fatty acid ester and (c) the second polyglycerol fatty acid ester is 0.5 or less, the composition contains an anionic surfactant of 0.1% by mass or less, preferably an anionic surfactant of 0.01% by mass or less, more preferably does not contain an anionic surfactant, This can be achieved by composition.

[0011] The composition according to the present invention may have a turbidity of 300 NTU or less, preferably 200 NTU or less, and more preferably 100 NTU or less.

[0012] (a) The oil may be selected from polar oils.

[0013] The amount of oil (a) in the composition according to the present invention may be in the range of 10% by mass or less, preferably 5% by mass or less, and more preferably 1% by mass or less, based on the total mass of the composition.

[0014] (b) The first polyglycerol fatty acid ester may contain 2 to 4 glycerol units, preferably 3 or 4 glycerol units, more preferably 4 glycerol units.

[0015] (b) The fatty acid portion of the first polyglycerol fatty acid ester may contain 12 or fewer carbon atoms, preferably 11 or fewer carbon atoms, and more preferably 10 or fewer carbon atoms.

[0016] (c) The second polyglycerol fatty acid ester may contain 2 to 4 glycerol units, preferably 2 or 3 glycerol units, more preferably 2 glycerol units.

[0017] (c) The fatty acid portion of the second polyglycerol fatty acid ester may contain 14 or more carbon atoms, preferably 16 or more carbon atoms, and more preferably 18 or more carbon atoms.

[0018] (b) The total amount of the first polyglycerol fatty acid ester and (c) the second polyglycerol fatty acid ester may be 0.05% by mass or more, preferably 0.1% by mass or more, and more preferably 1% by mass or more of the composition.

[0019] (d) The active ingredients for skincare may be selected from the group consisting of lactic acid, niacinamide, and mixtures thereof.

[0020] (d) The amount of skincare active ingredients may be 0.01% to 25% by mass, preferably 0.05% to 20% by mass, and more preferably 0.1% to 15% by mass, relative to the total mass of the composition.

[0021] The pH of the composition may be 3.5 to 9.0, preferably 4.0 to 8.0, more preferably 4.5 to 7.0, and even more preferably 4.0 to 6.0.

[0022] The composition according to the present invention may be in the form of a nano or micro oil-wheat emulsion. (a) The particle size of the oil may be 300 nm or less, preferably 200 nm or less, and more preferably 100 nm or less.

[0023] The present invention also relates to a cosmetic method for treating keratinous substances, comprising the step of applying a composition according to the present invention. [Modes for carrying out the invention]

[0024] As a result of diligent research, the inventors have discovered that it is possible to provide a composition comprising at least two different types of polyglycerin fatty acid esters, which may also contain skincare active ingredients, and which is in the form of nano or microemulsions.

[0025] The composition according to the present invention may be in the form of a nano or microemulsion, even though it contains at least two polyglycerin fatty acid esters and at least one skincare active ingredient.

[0026] One of the properties of the composition according to the present invention is, A first polyglycerol fatty acid ester having a higher HLB value, A second polyglycerol fatty acid ester having a lower HLB value and This is the combination.

[0027] The HLB value of the first polyglycerol fatty acid ester may fall into a higher HLB range, and the HLB value of the second polyglycerol fatty acid ester may fall into a lower HLB range, but the higher HLB range and the lower HLB range do not overlap with each other.

[0028] Another characteristic of the composition according to the present invention is that it contains at least one skincare active ingredient along with the above-mentioned combination of the first and second polyglycerin fatty acid esters. The composition according to the present invention contains a skincare active ingredient, but can be stable and maintain the form of a nano or microemulsion.

[0029] One aspect of the present invention is (a) at least one optional oil, (b) At least one first polyglycerol fatty acid ester having an HLB value of 13.0 or higher, preferably 13.5 or higher, and more preferably 14.0 or higher, (c) At least one second polyglycerol fatty acid ester having an HLB value of 10.0 or less, preferably 9.0 or less, and more preferably 8.0 or less, (d) at least one active ingredient for skincare, (e) water and A composition in the form of a nano or microemulsion containing, (b) The mass ratio of the amount of the first polyglycerol fatty acid ester to (c) the amount of the second polyglycerol fatty acid ester is 3.0 or more, preferably 4.0 or more, and more preferably 5.0 or more. (a) The mass ratio of the amount of oil to (b) the total amount of the first polyglycerol fatty acid ester and (c) the second polyglycerol fatty acid ester is 0.5 or less. The present invention relates to a composition that contains 0.1% by mass or less of an anionic surfactant, preferably 0.01% by mass or less of an anionic surfactant, and more preferably does not contain an anionic surfactant.

[0030] The composition according to the present invention can have a turbidity of 300 NTU or less, preferably 200 NTU or less, and more preferably 100 NTU or less, and therefore can be transparent or translucent.

[0031] The compositions according to the present invention can be prepared without using the large amount of energy required by a homogenizer. Therefore, the compositions according to the present invention can be prepared using a small amount of energy, for example, by gently stirring the components of the composition. Thus, the compositions according to the present invention are environmentally friendly in terms of their preparation method.

[0032] The compositions according to the present invention will be described in more detail below.

[0033] [oil] The composition of the present invention comprises (a) at least one optional oil. If two or more oils are used, they may be the same or different.

[0034] Here, "oil" refers to fatty compounds or fatty substances in liquid or paste (non-solid) form at atmospheric pressure (760 mmHg) and room temperature (25°C). Oils commonly used in cosmetics can be used alone or in combination. These oils may be volatile or non-volatile.

[0035] (a) The oil may be a non-polar oil such as hydrocarbon oil or silicone oil; a vegetable oil or animal oil, and a polar oil such as ester oil or ether oil; or a mixture thereof.

[0036] (a) The oil may be selected from the group consisting of plant or animal oils, synthetic oils, silicone oils, hydrocarbon oils, and aliphatic alcohols.

[0037] Examples of vegetable oils include, for instance, linseed oil, camellia oil, macadamia nut oil, corn oil, mink oil, olive oil, avocado oil, camellia oil, castor oil, safflower oil, jojoba oil, sunflower oil, almond oil, rapeseed oil, sesame oil, soybean oil, peanut oil, and mixtures thereof.

[0038] Examples of animal oils include, for instance, squalene and squalane.

[0039] Examples of synthetic oils include alkane oils, such as isododecane and isohexadecane, ester oils, ether oils, and artificial triglycerides.

[0040] Ester oils are preferably saturated or unsaturated linear or branched C1-C12 26 Aliphatic monoacid or polyacid and saturated or unsaturated linear or branched C1-C123 26 It is a liquid ester of an aliphatic monohydric alcohol or a polyhydric alcohol, and the total number of carbon atoms in the ester is 10 or more.

[0041] Preferably, in the case of a monohydric alcohol ester, at least one of the alcohol and acid from which the ester of the present invention is derived is branched.

[0042] Among monoesters of monoacids and monohydric alcohols, examples include ethyl palmitate, ethylhexyl palmitate, isopropyl palmitate, dicaprylyl carbonate, alkyl myristate, for example isopropyl myristate or ethyl myristate, isocetyl stearate, 2-ethylhexyl isononanoate, isononyl isononanoate, isodecyl neopentanoate, and isostearyl neopentanoate.

[0043] C4~C 22 Dicarboxylic acid or tricarboxylic acid and C1-C 22 Esters with alcohols, as well as monocarboxylic acids, dicarboxylic acids, or tricarboxylic acids, and nonsugars C4-C 26Esters with dihydroxy, trihydroxy, tetrahydroxy, or pentahydroxy alcohols can also be used.

[0044] In particular, the following can be mentioned: diethyl sebacate, isopropyl lauroyl sarcosine, diisopropyl sebacate, bis(2-ethylhexyl) sebacate, diisopropyl adipate, di-n-propyl adipate, dioctyl adipate, bis(2-ethylhexyl) adipate, diisostearyl adipate, bis(2-ethylhexyl) maleate, triisopropyl citrate, triisocetyl citrate, triisostearyl citrate, glyceryl trilactate, glyceryl trioctanoate, trioctyldodecyl citrate, trioleyl citrate, neopentyl glycol diheptanoate, diethylene glycol diisononanoate.

[0045] As the ester oil, sugar esters and diesters of C6-C 30 , preferably C 12 -C 22 fatty acids can be used. It should be recalled that the term "sugar" means a hydrocarbon compound containing several alcohol functional groups, having or not having an aldehyde or ketone functional group, and containing at least 4 carbon atoms and retaining oxygen. These sugars may be monosaccharides, oligosaccharides, or polysaccharides.

[0046] Examples of suitable sugars that can be mentioned include sucrose (or cane sugar), glucose, galactose, ribose, fucose, maltose, fructose, mannose, arabinose, xylose, and lactose, and derivatives thereof, especially alkyl derivatives, such as methyl derivatives, for example methyl glucose.

[0047] The sugar esters of fatty acids are, in particular, the aforementioned sugars and linear or branched saturated or unsaturated C6-C 30 , preferably C 12 -C 22The group may be selected from those comprising esters with fatty acids or mixtures of esters. When unsaturated, these compounds may have 1 to 3 conjugated or unconjugated carbon-carbon double bonds.

[0048] Esters in this modified form can also be selected from monoesters, diesters, triesters, tetraesters, and polyesters, as well as mixtures thereof.

[0049] These esters may be, for example, oleic acid esters, lauric acid esters, palmitic acid esters, myristic acid esters, behenic acid esters, coconut fatty acid esters, stearic acid esters, linoleic acid esters, linolenic acid esters, capric acid esters, and arachidonic acid esters, or mixtures thereof, for example, mixed esters of oleopalmitic acid, oleostearic acid, and palmitostearic acid, and pentaerythrityl tetraethylhexanoate.

[0050] More specifically, monoesters and diesters, particularly monooleates or dioleates, stearates, behenates, oleopalmitates, linoleates, linolenicates, and oleostearates of sucrose, glucose, or methyl glucose, are used.

[0051] One example that can be cited is methyl glucose dioleate, a product sold by Amerchol under the name Glucate(registered trademark) DO.

[0052] Examples of preferred ester oils include, for example, diisopropyl adipate, dioctyl adipate, 2-ethylhexyl hexanoate, ethyl laurate, cetyl octanoate, octyldodecyl octanoate, isodecyl neopentanoate, myristyl propionate, 2-ethylhexyl 2-ethylhexanoate, 2-ethylhexyl octanoate, 2-ethylhexyl caprylic / capric acid, methyl palmitate, ethyl palmitate, isopropyl palmitate, and dicaprate. Examples include lylyl, isopropyl lauroyl sarcosinate, isononyl isononanoate, ethylhexyl palmitate, isohexyl laurate, hexyl laurate, isocetyl stearate, isopropyl isostearate, isopropyl myristate, isodecyl oleate, glyceryl tri(2-ethylhexanoate), pentaerythrityl tetra(2-ethylhexanoate), ethylhexyl succinate, diethyl sebacate, and mixtures thereof.

[0053] Examples of artificial triglycerides include caprylcaprylyl glyceride, glyceryl trimyristicate, glyceryl tripalmitate, glyceryl trilinolenate, glyceryl trilaurate, glyceryl tricaprate, glyceryl tricaprylate, tri(caprate / caprylic acid)glyceryl, and tri(caprate / caprylic acid / linolenic acid)glyceryl.

[0054] Examples of silicone oils include, for example, linear organopolysiloxanes such as dimethylpolysiloxane, methylphenylpolysiloxane, and methylhydrogenpolysiloxane, cyclic organopolysiloxanes such as cyclohexasiloxane, octamethylcyclotetrasiloxane, decamethylcyclopentasiloxane, and dodecamethylcyclohexasiloxane, and mixtures thereof.

[0055] Preferably, the silicone oil is selected from liquid polydialkylsiloxanes, particularly liquid polydimethylsiloxane (PDMS), and liquid polyorganosiloxanes containing at least one aryl group.

[0056] These silicone oils may also be organically modified. Organically modified silicones that can be used according to the present invention are the silicone oils defined above, which contain one or more organic functional groups linked in their structure via hydrocarbon groups.

[0057] Organopolysiloxanes are defined in more detail in Walter Noll's *Chemistry and Technology of Silicones* (1968), Academic Press. They may be volatile or non-volatile.

[0058] If volatile, the silicone is selected more specifically from those having a boiling point between 60°C and 260°C, and even more specifically from the following: (i) Cyclic polydialkylsiloxanes containing 3 to 7, preferably 4 to 5, silicon atoms. These include, for example, octamethylcyclotetrasiloxane, sold by Union Carbide under the name Volatile Silicone® 7207, or by Rhodia under the name Silbione® 70045 V2; decamethylcyclopentasiloxane, sold by Union Carbide under the name Volatile Silicone® 7158 and by Rhodia under the name Silbione® 70045 V5; and dodecamethylcyclopentasiloxane, sold by Momentive Performance Materials under the name Silsoft 1217, as well as mixtures thereof. Formula:

[0059] [ka]

[0060] Examples of cyclocopolymers such as dimethylsiloxane / methylalkylsiloxane can also be cited.

[0061] Examples include mixtures of cyclic polydialkylsiloxanes and organosilicon compounds, such as a mixture of octamethylcyclotetrasiloxane and tetratrimethylsilylpentaerythritol (50 / 50), and a mixture of octamethylcyclotetrasiloxane and oxy-1,1'-bis(2,2,2',2',3,3'-hexatrimethylsilyloxy)neopentane.

[0062] (ii) Contains 2 to 9 silicon atoms and has a temperature of 5 × 10 at 25°C -6 m 2 Linear volatile polydialkylsiloxanes with a viscosity of less than / s. An example is decamethyltetrasiloxane, sold by Toray Silicone under the name SH 200. Silicones belonging to this category are also described in the article published in Cosmetics and Toiletries, Vol. 91, Jan. 76, pp. 27-32, Todd & Byers, Volatile Silicone Fluids for Cosmetics. The viscosity of silicones is measured at 25°C according to ASTM standard 445 Annex C.

[0063] Non-volatile polydialkylsiloxanes may be used. These non-volatile silicones are selected more specifically from polydialkylsiloxanes, among which polydimethylsiloxanes mainly containing trimethylsilyl terminal groups can be mentioned.

[0064] Among these polydialkylsiloxanes, the following commercially available products can be listed without limitation: - Silbione® oils 47 and 70 047 series or Mirasil® oils sold by Rhodia, for example, 70 047 V 500 000 oil. - Mirasil® series oils sold by Rhodia, - Dow Corning's 200 series oil, for example, 60,000 ml 2 DC200 having a viscosity of / s, and - Viscasil® oil manufactured by General Electric and certain oils in the SF series manufactured by General Electric (SF 96, SF 18).

[0065] Polydimethylsiloxanes containing dimethylsilanol terminal groups, known by the name dimethiconol (CTFA), such as the 48 series oils from Rhodia, can also be cited.

[0066] Among silicones containing aryl groups, polydiarylsiloxanes, particularly polydiphenylsiloxanes and polyalkylarylsiloxanes, such as phenyl silicone oil, can be cited.

[0067] Phenylsilicone oil is given by the following formula:

[0068] [ka]

[0069] (In the formula, R1~R 10 These are, independently of each other, saturated or unsaturated, linear, cyclic or branched C1-C12 30 Hydrocarbon groups, preferably C1-C 12 A hydrocarbon group, more preferably a C1-C6 hydrocarbon group, particularly a methyl, ethyl, propyl, or butyl group. m, n, p, and q are integers independently of each other, ranging from 0 to 900, preferably from 0 to 500, and more preferably from 0 to 100, including both ends. (However, the sum of n+m+q is non-zero.) It can be selected from phenyl silicones.

[0070] Examples that can be given include products sold under the following names: - Silbione® oil 70 641 series manufactured by Rhodia, - Rhodorsil® 70 633 and 763 series oils manufactured by Rhodia, - Dow Corning 556 Cosmetic Grade Fluid, manufactured by Dow Corning. - Bayer's PK series silicones, for example, product PK20, - Certain oils from General Electric's SF series, such as SF 1023, SF 1154, SF 1250, and SF 1265.

[0071] As phenyl silicone oil, phenyl trimethicone (in the above formula, R1 to R 10 (where is methyl, and p, q, and n = 0, and m = 1) is preferred.

[0072] Organically modified liquid silicones may, in particular, contain polyethylene oxy and / or polypropylene oxy groups. Examples include silicone KF-6017 proposed by Shin-Etsu Chemical Co., Ltd., and Silwet® L722 and L77, oils manufactured by Union Carbide.

[0073] Hydrocarbon oils can be selected from the following: - Linear or branched, optionally cyclic C6-C 16 Lower alkanes. Examples include hexane, undecane, dodecane, tridecane, and isoparaffins, such as isohexadecane, isododecane, and isodecane. - Linear or branched hydrocarbons containing more than 16 carbon atoms, such as liquid paraffin, liquid petroleum jelly, polydecene, and hydrogenated polyisobutene, such as Parleam®, and squalane.

[0074] Preferred examples of hydrocarbon oils include, for example, linear or branched hydrocarbons such as isohexadecane, isododecane, squalane, mineral oil (e.g., liquid paraffin), paraffin, petrolatum or petrolatum, and naphthalene; hydrogenated polyisobutene, isoeicosane, and decene / butene copolymers; and mixtures thereof.

[0075] In the context of aliphatic alcohols, the term "aliphatic" refers to the inclusion of a relatively large number of carbon atoms. Therefore, alcohols having four or more, preferably six or more, and more preferably twelve or more carbon atoms are included within the range of aliphatic alcohols. Aliphatic alcohols may be saturated or unsaturated. Aliphatic alcohols may be linear or branched.

[0076] Aliphatic alcohols may have the structure R-OH (wherein R is selected from saturated and unsaturated, linear and branched groups containing 4 to 40 carbon atoms, preferably 6 to 30 carbon atoms, more preferably 12 to 20 carbon atoms). In at least one embodiment, R is C 12 ~C 20 Alkyl and C 12 ~C 20 It can be selected from alkenyl groups. R may or may not be substituted with at least one hydroxyl group.

[0077] Examples of aliphatic alcohols include lauryl alcohol, cetyl alcohol, stearyl alcohol, isostearyl alcohol, behenyl alcohol, undecylenyl alcohol, myristyl alcohol, octyldodecanol, hexyldecanol, oleyl alcohol, linoleyl alcohol, palmitrail alcohol, arachidonyl alcohol, erucyl alcohol, and mixtures thereof.

[0078] The aliphatic alcohol is preferably a saturated aliphatic alcohol.

[0079] Therefore, aliphatic alcohols are linear or branched saturated or unsaturated C6-C6 alcohols. 30 Alcohols, preferably linear or branched saturated C6-C6 compounds. 30 Alcohol, more preferably linear or branched saturated carbon 12 ~C 20 Alcohol can be selected.

[0080] The term "saturated aliphatic alcohol" here refers to an alcohol having a long chain of aliphatic saturated carbon atoms. Saturated aliphatic alcohols are any linear or branched, saturated C6-C6 alcohols. 30 Preferably selected from aliphatic alcohols. Linear or branched saturated C6-C6 30 Among aliphatic alcohols, linear or branched saturated carbon 12 ~C 20 Aliphatic alcohols may be preferably used. Any linear or branched saturated C 16 ~C 20 Aliphatic alcohols may be more preferably used. Branched C 16 ~C 20 Aliphatic alcohols may be used more preferably.

[0081] Examples of saturated aliphatic alcohols include lauryl alcohol, cetyl alcohol, stearyl alcohol, isostearyl alcohol, behenyl alcohol, undecylenyl alcohol, myristyl alcohol, octyldodecanol, hexyldecanol, and mixtures thereof. In one embodiment, cetyl alcohol, stearyl alcohol, octyldodecanol, hexyldecanol, or mixtures thereof (e.g., cetearyl alcohol), and behenyl alcohol can be used as saturated aliphatic alcohols.

[0082] According to at least one embodiment, the aliphatic alcohol used in the composition according to the present invention is preferably selected from cetyl alcohol, octyldodecanol, hexyldecanol, and mixtures thereof.

[0083] (a) The oil may also be selected from oils having a molecular weight of less than 600 g / mol.

[0084] Preferably, (a) the oil has a low molecular weight such as less than 600 g / mol and contains short-chain hydrocarbons (C1-C1). 12 Ester oils having (e.g., isopropyl lauroyl sarcosinate, isopropyl myristate, isopropyl palmitate, isononyl isononanoate and ethylhexyl palmitate), silicone oils (e.g., volatile silicones such as cyclohexasiloxane), hydrocarbon oils (e.g., isododecane, isohexadecane and squalane), branched and / or unsaturated aliphatic alcohols (C 12 ~C 30 The oils are selected from among types such as octyldodecanol and oleyl alcohol, and ether oils such as dicaprylyl ether.

[0085] (a) The oil is preferably selected from polar oils, and more preferably from ester oils.

[0086] (a) The oil may constitute the dispersed phase of the composition according to the present invention, with or without any other possible hydrophobic components in the composition.

[0087] (a) Oil is optional. Therefore, the composition according to the present invention may or may not contain (a) oil. If the composition according to the present invention does not contain (a) oil, the dispersed phase of the composition according to the present invention may be formed by at least (b) a first polyglycerol fatty acid ester and (c) a second polyglycerol fatty acid ester, as described below.

[0088] The composition according to the present invention preferably contains (a) oil. If the composition according to the present invention contains (a) oil, it may be possible to provide a skin moisturizing effect due to (a) oil and / or enhance the penetration of (d) skincare active ingredients as described below.

[0089] The amount of (a) oil in the composition according to the present invention may be 0.001% by mass or more, preferably 0.005% by mass or more, and more preferably 0.01% by mass or more, based on the total mass of the composition.

[0090] The amount of (a) oil in the composition according to the present invention may be 10% by mass or less, preferably 5% by mass or less, and more preferably 1% by mass or less, based on the total mass of the composition.

[0091] The amount of (a) oil in the composition according to the present invention may be 0.001% to 10% by mass, preferably 0.005% to 5% by mass, and more preferably 0.01% to 1% by mass, based on the total mass of the composition.

[0092] [First polyglycerol fatty acid ester] The composition according to the present invention comprises (b) at least one first polyglycerol fatty acid ester having an HLB value of 13.0 or higher, preferably 13.5 or higher, and more preferably 14.0 or higher. A single type of (b) first polyglycerol fatty acid ester may be used, or two or more different types of (b) first polyglycerol fatty acid esters may be used in combination.

[0093] (b) The first polyglycerol fatty acid ester can function as a surfactant, in particular as a nonionic surfactant.

[0094] (b) The first polyglycerol fatty acid ester may have an HLB value of 13.0 to 17.0, preferably 13.5 to 16.0, and more preferably 14.0 to 15.0.

[0095] The term HLB ("hydrophilic-lipophilic balance") is well known to those skilled in the art and represents the ratio of hydrophilic to lipophilic parts in a molecule.

[0096] If two or more (b) first polyglycerol fatty acid esters are used, the HLB value is determined by the weighted average of the HLB values ​​of all (b) first polyglycerol fatty acid esters.

[0097] (b) The first polyglycerol fatty acid ester may be selected from mono, di, tri and more esters of saturated or unsaturated fatty acids.

[0098] (b) The first polyglycerol fatty acid ester preferably contains 2 to 4 glycerol units, preferably 3 or 4 glycerol units, more preferably 4 glycerol units.

[0099] (b) The fatty acid or fatty acid portion for the fatty acid portion of the first polyglycerol fatty acid ester may contain 12 or fewer carbon atoms, preferably 11 or fewer carbon atoms, more preferably 10 or fewer carbon atoms. (b) The fatty acid or fatty acid portion for the fatty acid portion of the first polyglycerol fatty acid ester may contain 4 or more carbon atoms, preferably 6 or more carbon atoms, more preferably 8 or more carbon atoms. (b) The fatty acid or fatty acid portion for the fatty acid portion of the first polyglycerol fatty acid ester may have 4 to 12 carbon atoms, preferably 6 to 11, more preferably 8 to 10 carbon atoms.

[0100] (b) The fatty acid for the fatty acid portion of the first polyglycerol fatty acid ester may be saturated or unsaturated and may be selected from caprylic acid, capric acid, and lauric acid.

[0101] (b) The first polyglycerin fatty acid ester is PG3 caprate (HLB: approx. 14), PG4 caprylate (HLB: 14), PG4 laurate (HLB: approx. 14), PG4 caprate (HLB: 14), PG5 myristate (HLB: 15.4), PG5 stearate (HLB: 15), PG6 caprylate (HLB: 14.6), PG6 caprate (HLB: 13.1) ), PG6 laurate (HLB: 14.1), PG10 laurate (HLB: 15.2), PG10 myristic acid (HLB: 14.9), PG10 stearate (HLB: 14.1), PG10 isostearate (HLB: 13.7), PG10 oleate (HLB: 13.0), PG10 coconut fatty acid (HLB: 16), and mixtures thereof may be selected from the group.

[0102] (b) The first polyglycerol fatty acid ester may preferably be selected from the group consisting of PG3 caprate (HLB: about 14), PG4 caprylate (HLB: 14), PG4 laurate (HLB: about 14), PG4 caprate (HLB: 14), and mixtures thereof.

[0103] The amount of (b) the first polyglycerol fatty acid ester in the composition according to the present invention may be 0.01% by mass or more, preferably 0.05% by mass or more, and more preferably 0.1% by mass or more, based on the total mass of the composition.

[0104] On the other hand, the amount of (b) the first polyglycerol fatty acid ester in the composition according to the present invention may be 15% by mass or less, preferably 10% by mass or less, and more preferably 5% by mass or less, based on the total mass of the composition.

[0105] The amount of (b) the first polyglycerol fatty acid ester in the composition according to the present invention may be in the range of 0.01% to 15% by mass, preferably 0.05% to 10% by mass, and more preferably 0.1% to 5% by mass, based on the total mass of the composition.

[0106] The mass ratio of (b) the amount of the first polyglycerin fatty acid ester to (a) the amount of oil in the composition according to the present invention may be 1 or more, preferably 1.5 or more, and more preferably 2 or more.

[0107] The mass ratio of (b) the amount of the first polyglycerin fatty acid ester / (a) the amount of oil in the composition according to the present invention may be 10 or less, preferably 9.5 or less, and more preferably 9 or less.

[0108] The mass ratio of (b) the amount of the first polyglycerin fatty acid ester to (a) the amount of oil in the composition according to the present invention may be in the range of 1 to 10, preferably 1.5 to 9.5, and more preferably 2 to 9.

[0109] [Second type of polyglycerin fatty acid ester] The composition according to the present invention comprises (c) at least one second polyglycerol fatty acid ester having an HLB value of 10.0 or less, preferably 9.0 or less, and more preferably 8.0 or less. A single type of (c) second polyglycerol fatty acid ester may be used, or two or more different types of (c) second polyglycerol fatty acid esters may be used in combination.

[0110] (c) The second polyglycerol fatty acid ester can function as a surfactant, particularly a nonionic surfactant.

[0111] The second polyglycerol fatty acid ester may have an HLB value of 5.0 to 10.0, preferably 6.0 to 9.0, and more preferably 7.0 to 8.0.

[0112] If two or more (c) second polyglycerol fatty acid esters are used, the HLB value is determined by the weighted average of the HLB values ​​of all (c) second polyglycerol fatty acid esters.

[0113] (c) The second polyglycerol fatty acid ester may be selected from mono, di, tri and more esters of saturated or unsaturated fatty acids.

[0114] (c) The second polyglycerol fatty acid ester preferably contains 2 to 4 glycerol units, preferably 2 or 3 glycerol units, and more preferably 2 glycerol units.

[0115] (c) The fatty acid or fatty acid portion for the fatty acid portion of the second polyglycerol fatty acid ester may contain 14 or more carbon atoms, preferably 16 or more carbon atoms, more preferably 18 or more carbon atoms. (c) The fatty acid or fatty acid portion for the fatty acid portion of the second polyglycerol fatty acid ester may contain 30 or fewer carbon atoms, preferably 24 or fewer carbon atoms, more preferably 20 or fewer carbon atoms. (c) The fatty acid or fatty acid portion for the fatty acid portion of the second polyglycerol fatty acid ester may have 14 to 30 carbon atoms, preferably 16 to 24, more preferably 18 to 20 carbon atoms.

[0116] (c) The fatty acid for the fatty acid portion of the second polyglycerol fatty acid ester may be saturated or unsaturated and may be selected from myristic acid, stearic acid, isostearic acid, and oleic acid.

[0117] (c) The second polyglycerin fatty acid ester is PG2 stearate (HLB: 5.0), PG2 distearate (HLB: 4), PG2 isostearate (HLB: 8), PG2 diisostearate (HLB: 3.2), PG2 triisostearate (HLB: 3), PG2 sesquiisostearate (HLB: approximately 4), PG2 oleate (HLB: 8), PG2 sesquioleate (HLB: 5.3), PG3 distearate (HLB: 5), PG3 diisostearate (HLB: 5), PG3 coconut fatty acid (HLB: 7), PG5 hexastearate (HLB: 4.0), PG5 trioleate (HLB: 7.0), PG10 pentaoleate (HLB: 6 4) The following can be selected from the group consisting of PG2 sesquicaprylate (HLB: approximately 8), PG2 caprate (HLB: 9.5), PG2 laurate (HLB: 8.5), PG2 myristate (HLB: 10), PG2 isopalmitate (HLB: 9), PG4 oleate (HLB: 10), PG4 stearate (HLB: 9), PG4 isostearate (HLB: 8.2), PG6 distearate (HLB: 8), PG10 distearate (HLB: approximately 9), PG10 tristearate (HLB: 8), PG10 diisostearate (HLB: 10), PG10 triisostearate (HLB: 8), PG10 coconut fatty acid (HLB: 9), and mixtures thereof.

[0118] (c) The second polyglycerin fatty acid ester is PG2 stearate (HLB: 5.0), PG2 distearate (HLB: 4), PG2 isostearate (HLB: 8), PG2 diisostearate (HLB: 3.2), PG2 triisostearate (HLB: 3), PG2 sesquiisostearate (HLB: approximately 4), PG2 oleate (HLB: 8), PG2 sesquioleate (HLB: 5.3), PG3 distearate (HLB: 5), P2 diisostearate It may also be preferable to select from the group consisting of G3 (HLB: 5), coconut fatty acid PG3 (HLB: 7), sesquicaprylic acid PG2 (HLB: approximately 8), capric acid PG2 (HLB: 9.5), laurate PG2 (HLB: 8.5), myristic acid PG2 (HLB: 10), isopalmitic acid PG2 (HLB: 9), oleic acid PG4 (HLB: 10), stearate PG4 (HLB: 9), isostearate PG4 (HLB: 8.2), and mixtures thereof.

[0119] The amount of (c) the second polyglycerol fatty acid ester in the composition according to the present invention may be 0.01% by mass or more, preferably 0.05% by mass or more, and more preferably 0.1% by mass or more, based on the total mass of the composition.

[0120] On the other hand, the amount of (c) second polyglycerol fatty acid ester in the composition according to the present invention may be 10% by mass or less, preferably 5% by mass or less, and more preferably 1% by mass or less, based on the total mass of the composition.

[0121] The amount of (c) second polyglycerol fatty acid ester in the composition according to the present invention may be in the range of 0.01% to 10% by mass, preferably 0.05% to 5% by mass, and more preferably 0.1% to 1% by mass, based on the total mass of the composition.

[0122] The mass ratio of (c) the amount of the second polyglycerin fatty acid ester to (a) the amount of oil in the composition according to the present invention may be 0.1 or more, preferably 0.2 or more, and more preferably 0.25 or more.

[0123] The mass ratio of (c) the amount of the second polyglycerin fatty acid ester to (a) the amount of oil in the composition according to the present invention may be 4 or less, preferably 3 or less, and more preferably 2 or less.

[0124] The mass ratio of (c) the amount of the second polyglycerin fatty acid ester to (a) the amount of oil in the composition according to the present invention may be in the range of 0.1 to 4, preferably 0.2 to 3, and more preferably 0.25 to 2.

[0125] [Mass ratio of oil / first and second polyglycerin fatty acid esters] According to the present invention, the mass ratio of (a) amount of oil / ((b) total amount of the first polyglycerin fatty acid ester and (c) second polyglycerin fatty acid ester) is 0.5 or less, preferably 0.45 or less, and more preferably 0.4 or less.

[0126] The mass ratio of (a) amount of oil / ((b) total amount of the first polyglycerol fatty acid ester and (c) second polyglycerol fatty acid ester) may be 0.01 or more, preferably 0.03 or more, and more preferably 0.05 or more.

[0127] The mass ratio of (a) amount of oil / ((b) total amount of the first polyglycerol fatty acid ester and (c) second polyglycerol fatty acid ester) may be 0.01 to 0.5, preferably 0.03 to 0.45, and more preferably 0.05 to 0.4.

[0128] [Mass ratio of the first polyglycerol fatty acid ester / the second polyglycerol fatty acid ester] (b) The mass ratio of the amount of the first polyglycerol fatty acid ester to (c) the amount of the second polyglycerol fatty acid ester is 3.0 or more, preferably 4.0 or more, and more preferably 5.0 or more.

[0129] (b) The mass ratio of the amount of the first polyglycerol fatty acid ester to (c) the amount of the second polyglycerol fatty acid ester may be 20 or less, preferably 19 or less, and more preferably 18 or less.

[0130] (b) The mass ratio of the amount of the first polyglycerol fatty acid ester to (c) the amount of the second polyglycerol fatty acid ester may be 3.0 to 20, preferably 4.0 to 19, and more preferably 5.0 to 18.

[0131] [Skincare active ingredients] The composition according to the present invention comprises (d) at least one skincare active ingredient. If two or more skincare active ingredients are used, they may be the same or different.

[0132] (d) The skincare active ingredient preferably has a logP value in the range of -4.5 to 4.5, preferably -4.0 to 4.0, and more preferably -3.5 to 3.5.

[0133] The log P value is the base-10 logarithm of the apparent partition coefficient of octanol-1-ol / water. The log P value is publicly known and determined by standard tests that determine the concentration of the compound in octanol-1-ol and water. log P can be calculated using the method described in the article by Meylan and Howard: Atom / Fragment contribution method for estimating octanol-water partition coefficients, J. Pharm. Sci., 84: 83-92, 1995. This value can also be calculated using numerous commercially available software packages, which determine log P as a function of the molecular structure. An example is the Epiwin software from the U.S. Environmental Protection Agency.

[0134] This value can be calculated, in particular, using the ACD (Advanced Chemistry Development) Solaris software V4.67, or it can be obtained from Exploring QSAR: hydrophobic, electronic, and steric constants (ACS professional reference book, 1995). There are also websites that provide approximate values ​​(address: http: / / esc.syrres.com / interkow / kowdemo.htm).

[0135] (d) The active ingredient in skincare may be in the form of a salt. (d) Examples of salts of the active ingredient in skincare include conventional non-toxic salts of the compound, for example, those formed from an acid or a base.

[0136] (d) The skincare active ingredient is preferably a skincare beauty active ingredient, more preferably a skin peeling agent, a skin whitening agent, or a skin anti-aging agent, such as an anti-wrinkle agent.

[0137] (d) Vitamin B3 and its derivatives can be cited as active ingredients for skincare.

[0138] Vitamin B3, also known as vitamin PP, is expressed by the following formula:

[0139] [ka]

[0140] (In the formula, R may be -CONH2 (niacinamide), -COOH (nicotinic acid or niacin), CH2OH (nicotinyl alcohol), -CO-NH-CH2-COOH (nicotinuric acid), or -CO-NH-OH (nicotinylhydroxamic acid)) It is a compound of [substance name]. Niacinamide is preferred.

[0141] Examples of vitamin B3 derivatives include nicotinic acid SL such as tocopherol nicotinate, amides derived from niacinamide by substitution of the hydrogen group of -CONH2, products from reactions with carboxylic acids and amino acids, and esters of nicotinyl alcohol with carboxylic acids, such as acetic acid, salicylic acid, glycolic acid, or palmitic acid.

[0142] The following derivatives may also be listed: 2-chloronicotinamide, 6-methylnicotinamide, 6-aminonicotinamide, N-methylnicotinamide, N,N-dimethylnicotinamide, N-(hydroxymethyl)nicotinamide, quinolinimide, nicotinanilide, N-benzylnicotinamide, N-ethylnicotinamide, nifenazone, nicotinaldehyde, isonicotinic acid, methylisonicotinic acid, thionicotinamide, niaramide, 2-mercaptonicotinic acid, nicomole and niaprazine, methyl nicotinate, and sodium nicotinate.

[0143] Other vitamin B3 derivatives that can be mentioned include their inorganic salts, such as chlorides, bromides, iodides, or carbonates, and their organic salts, such as those obtained by reaction with carboxylic acids, such as acetates, salicylates, glycolates, lactates, malates, citrates, mandelates, and tartrates.

[0144] (d) As skincare active ingredients, ascorbic acid and its derivatives can be cited.

[0145] Ascorbic acid is generally in its L-form because it is usually extracted from natural products.

[0146] Due to its chemical structure (α-ketractone), which makes it highly sensitive to certain environmental parameters, such as light, heat, and aqueous media, ascorbic acid may be advantageous to use in the form of, for example, sugar esters of ascorbic acid, or derivatives or analogs selected from metal salts, alkali metal salts, esters, and sugars of phosphoryl ascorbic acid.

[0147] The sugar esters of ascorbic acid that can be used in the present invention include, in particular, glycosyl, mannosyl, fructosyl, fucosyl, galactosyl, N-acetylglucosamine and N-acetylmuramic acid derivatives of ascorbic acid, and mixtures thereof, more specifically, ascorbyl glucosides, such as ascorbyl-2-glucoside, 2-O-α-D-glucopyranosyl L-ascorbic acid, or 6-O-β-D-galactopyranosyl L-ascorbic acid. The latter compounds and methods for preparing them are described in particular in references EP-A-0 487 404, EP-A-0 425 066, and Japanese Patent Publication No. 05-213736.

[0148] Regarding the metal salts of phosphoryl ascorbic acid, they can be selected from alkali metal salts of ascorbyl phosphate, particularly sodium ascorbyl phosphate, alkaline earth metal salts of ascorbyl phosphate, and transition metal salts of ascorbyl phosphate.

[0149] Ascorbic acid precursors such as activator amide derivatives and activator sugar derivatives can also be used, each requiring a protease or peptidase and a glycosidase, respectively, as enzymes for the in situ release of ascorbic acid. Such compounds are described in Japanese Patent EP 0 667 145.

[0150] The activating sugar derivatives are selected from C3-C6 sugar derivatives in particular. These are selected from glucosyl, mannosyl, fructosyl, fucosyl, N-acetylglucosamine, galactosyl, and N-acetylgalactosamine derivatives, N-acetylmuramic acid derivatives, and sialic acid derivatives, as well as mixtures thereof.

[0151] The second ascorbic acid precursor may be selected from derivatives that are hydrolyzed by other enzymes, such as esterases, phosphatases, sulfatases, etc. According to the present invention, the second activator precursor may be selected from, for example, phosphate esters, sulfate esters, palmitate esters, acetate esters, propionic acid esters, ferulic acid esters, and generally alkyl or acyl esters, acyl or alkyl ethers of the activator. Acyls and alkyl groups particularly contain 1 to 30 carbon atoms. 3-O-ethyl ascorbic acid can be cited as an active ingredient in skincare.

[0152] In particular, the second precursor may be an ester derived from a reaction with a mineral acid, such as a sulfuric acid ester or phosphate ester, which reacts with a sulfatase or phosphatase when it comes into contact with the skin, or the second precursor may be an acyl or alkyl ester derived from a reaction with an organic acid, such as palmitic acid, acetic acid, propionic acid, nicotinic acid, 1,2,3-propanetricarboxylic acid, or ferulic acid, which reacts with a specific skin esterase.

[0153] Other derivatives are described, for example, in Japanese Patent EP 1 430 883.

[0154] Ascorbic acid analogs, more specifically, are salts thereof, in particular alkali metal salts such as sodium ascorbate, esters thereof, in particular acetate esters, propionic acid esters, or palmitic acid esters, etc., or sugars thereof, in particular glycosyl ascorbic acid, etc.

[0155] (d) Resorcinol derivatives can be cited as active ingredients in skincare.

[0156] Resorcinol derivatives are preferably derivatives substituted at the 4-position, such as 4-alkylresorcinol, more preferably phenylethyl resorcinol, 4-n-butylresorcinol, and 4-(tetrahydro-2H-pyran-4-yl)benzene-1,3-diol, and in particular phenylethyl resorcinol may be used for its whitening effect. Phenylethyl resorcinol is also called 4-(1-phenylethyl)-1,3-benzenediol and is represented by the following chemical formula. Phenylethyl resorcinol can be obtained, for example, from Symrise Corp. (product name: Symwhite 377(registered trademark)).

[0157] [ka]

[0158] Other examples of resorcinol derivatives include: 2-methylresorcinol, 5-methylresorcinol, 4-methylresorcinol, 4-ethylresorcinol, 2,5-dimethylresorcinol, 4,5-dimethylresorcinol, 2,4-dimethyl-1,3-benzenediol, 3,5-dihydroxybenzylamine, 5-methoxyresorcinol, 3,5-dihydroxybenzyl alcohol, 2-methoxyresorcinol, 4-methoxyresorcinol, 3,5-dihydroxytoluene monohydrate, 4-chlororesorcinol, 2-chlororesorcinol, 2',4'-dihydro Xyacetophenone, 3',5'-dihydroxyacetophenone, 2,6-dihydroxy-4-methylbenzaldehyde, 4-propylresorcinol, 2,4-dihydroxy-1,3,5-trimethylbenzene, 3,5-dihydroxybenzamide, 2,6-dihydroxybenzamide, 2,4-dihydroxybenzamide, 2,4-dihydroxybenzoic acid, 2,6-dihydroxybenzoic acid, 3,5-dihydroxybenzoic acid, 2,6-dihydroxy-4-methylbenzyl alcohol, 3,5-dihydroxyanisole hydrate, 4-Ami Noresorcinol hydrochloride, 2-aminoresorcinol hydrochloride, 5-aminobenzene-1,3-diol hydrochloride, 2',4'-dihydroxypropiophenone, 2',4'-dihydroxy-3'-methylacetophenone, (2,4-dihydroxyphenyl)acetone, (3,5-dihydroxyphenyl)acetone, 2,6-dihydroxy-4'-methylacetophenone, 4-n-butylresorcinol, 2,4-diethyl-1,3-benzenediol, 3,5-dihydroxy-4-methylbenzoic acid, 2,6-dihydroxy-4-methylbenzoic acid Fragrant acid, 2,4-dihydroxy-6-methylbenzoic acid, 3,5-dihydroxyphenylacetic acid, 2-ethyl-5-methoxybenzene-1,3-diol, 4-amino-3,5-dihydroxybenzoic acid, 3,5-dihydroxyacetophenone monohydrate, 3,5-dihydroxybenzylamine hydrochloride, 4,6-dichlororesorcinol, 2',4'-dihydroxy-3'-methylpropiophenone, 1-(3-ethyl-2,6-dihydroxyphenyl)ethane-1-one, 2',6'-dihydroxy-4'-methoxyacetophenone, 1-(2,6-Dihydroxy-3-methoxyphenyl)ethane-1-one, 3(2,4-dihydroxyphenylpropionic acid, and 2,4-dihydroxy-3,6-dimethylbenzoic acid.

[0159] (d) C-glycoside derivatives can be cited as active ingredients in skincare.

[0160] The C-glycoside derivatives that may be present in the composition according to the present invention are given by the following general formula (II):

[0161] [ka]

[0162] (In the formula, R represents an unsubstituted linear C1-C4, particularly a C1-C2 alkyl group, especially a methyl group. S represents a monosaccharide selected from D-glucose, D-xylose, N-acetyl-D-glucosamine, and L-fucose, particularly D-xylose. X represents a group selected from -CO-, -CH(OH)-, and -CH(NH2)-, preferably from the -CH(OH)- group. The compounds, as well as their salts, solvates, such as hydrates, and optical isomers, which are also acceptable as cosmetics, can be selected.

[0163] Non-limiting examples of C-glycoside derivatives more specifically suited for use in the present invention include, in particular, the following derivatives: C-Beta-D-xylopyranoside-n-propan-2-one, C-alpha-D-xylopyranoside-n-propan-2-one, C-Beta-D-xylopyranoside-2-hydroxypropane, C-alpha-D-xylopyranoside-2-hydroxypropane, 1-(C-beta-D-glucopyranosyl)-2-hydroxypropane, 1-(C-alpha-D-glucopyranosyl)-2-hydroxypropane, 1-(C-beta-D-glucopyranosyl)-2-aminopropane, 1-(C-alpha-D-glucopyranosyl)-2-aminopropane, 3'-(acetamido-C-beta-D-glucopyranosyl)propan-2'-one, 3'-(acetamido-C-alpha-D-glucopyranosyl)propan-2'-one, 1-(acetamide-C-beta-D-glucopyranosyl)-2-hydroxypropane, 1-(acetamide-C-beta-D-glucopyranosyl)-2-aminopropane, Also permitted as cosmetic products are these salts, these solvates, e.g., hydrates, and their optical isomers.

[0164] According to detailed embodiments, C-beta-D-xylopyranoside-2-hydroxypropane or C-alpha-D-xylopyranoside-2-hydroxypropane, and more preferably C-beta-D-xylopyranoside-2-hydroxypropane, may be used to prepare the compositions according to the present invention.

[0165] According to detailed embodiments, a C-glycoside derivative suitable for use in the present invention is, advantageously, also known as C-beta-D-xylopyranoside-2-hydroxypropane, and in particular, hydroxypropyltetrahydropyranotriol, which is sold by Chimex under the name Mexoryl SBB® as a 30% by mass solution in a water / propylene glycol mixture (60 / 40). According to one embodiment, the C-glycoside derivative is in solution form, in which the C-glycoside derivative is present in an amount of 30% by mass of the total mass of the solution, with the remainder being a mixture of water and propylene glycol.

[0166] Salts of C-glycoside derivatives suitable for use in the present invention may include conventional physiologically acceptable salts of these compounds, such as salts formed from organic acids or mineral acids. Examples include salts of mineral acids such as sulfuric acid, hydrochloric acid, hydrobromic acid, hydroiodic acid, phosphoric acid, and boric acid. Salts of organic acids may also be included, which may contain one or more carboxylic acid groups, sulfonic acid groups, or phosphonic acid groups. These may be linear, branched, or cyclic aliphatic acids, or aromatic acids. These acids may also contain one or more heteroatoms selected from O and N, for example, in the form of a hydroxyl group. In particular, propionic acid, acetic acid, terephthalic acid, citric acid, and tartaric acid can be mentioned.

[0167] The solvates acceptable for the above compounds include conventional solvates, for example, those formed during the final step of the preparation of the compound due to the presence of a solvent. Examples include solvates resulting from the presence of water or linear or branched alcohols, such as ethanol or isopropanol.

[0168] Suitable C-glycoside derivatives for use in the present invention can be obtained, in particular, by the synthesis method described in reference WO 02 / 051 828, the contents of which are incorporated herein by reference.

[0169] (d) Salicylic acid and its derivatives can be cited as active ingredients in skincare. Derivatives of salicylic acid are given by formula (III):

[0170] [ka]

[0171] (In the formula, The R group represents a linear, branched, or cyclic saturated aliphatic chain containing 2 to 22 carbon atoms; an unsaturated chain containing 2 to 22 carbon atoms and possibly one or more conjugated double bonds; an aromatic nucleus linked to a carbonyl group directly or via a saturated or unsaturated aliphatic chain containing 2 to 7 carbon atoms, wherein the groups may be the same or different, and may be optionally substituted by one or more substituents selected from (a) a halogen atom, (b) a trifluoromethyl group, (c) a hydroxyl group in its free form or esterified with an acid containing 1 to 6 carbon atoms, or (d) a carboxyl functional group in its free form or esterified with a lower alcohol containing 1 to 6 carbon atoms. (R' is a hydroxyl group) It can be represented by [formula]. Salicylic acid derivatives may also be in the form of salts derived from inorganic or organic bases.

[0172] (d) The active ingredient in the skincare may be selected from alpha-hydroxy acids.

[0173] The term "α-hydroxy acid" or "AHA" here refers to a carboxylic acid having at least one hydroxyl group on an adjacent (alpha) carbon atom.

[0174] Alpha-hydroxy acids can function as skin peeling agents. It may also be preferable to use alpha-hydroxy acids that can function as soft skin peeling agents.

[0175] The α-hydroxy acid can be selected from, for example, glycolic acid, lactic acid, malic acid, citric acid, tartaric acid, mandelic acid, and gluconic acid, as well as mixtures thereof, preferably from lactic acid, glycolic acid, and citric acid, as well as mixtures thereof, and more preferably from lactic acid.

[0176] (d) The active ingredient for skincare is preferably selected from the group consisting of lactic acid, niacinamide, and mixtures thereof.

[0177] The amount of (d) skincare active ingredient in the composition according to the present invention may be 0.01% by mass or more, preferably 0.05% by mass or more, and more preferably 0.1% by mass or more, based on the total mass of the composition.

[0178] On the other hand, the amount of (d) skincare active ingredient in the composition according to the present invention may be 25% by mass or less, preferably 20% by mass or less, and more preferably 15% by mass or less, based on the total mass of the composition.

[0179] The amount of (d) skincare active ingredient in the composition according to the present invention may be in the range of 0.01% to 25% by mass, preferably 0.05% to 20% by mass, and more preferably 0.1% to 15% by mass, relative to the total mass of the composition.

[0180] (d) If the active ingredient in skincare is lactic acid, the amount may be 0.1% to 10% by mass, preferably 0.2% to 9.5% by mass, and more preferably 0.3% to 9% by mass, relative to the total mass of the composition.

[0181] (d) If the active ingredient in skincare is niacinamide, the amount may be 0.1% to 20% by mass, preferably 0.3% to 18% by mass, and more preferably 0.5% to 15% by mass, based on the total mass of the composition.

[0182] [water] The composition according to the present invention comprises (e) water.

[0183] (e) Water may, with or without any other possible hydrophilic components in the composition, form an aqueous phase which is a continuous phase of the composition according to the present invention.

[0184] The amount of (e) water in the composition according to the present invention may be 60% by mass or more, preferably 65% ​​by mass or more, and more preferably 70% by mass or more, based on the total mass of the composition.

[0185] On the other hand, the amount of (e) water in the composition according to the present invention may be 95% by mass or less, preferably 90% by mass or less, and more preferably 85% by mass or less, based on the total mass of the composition.

[0186] The amount of water (e) in the composition according to the present invention may be in the range of 60% to 95% by mass, preferably 65% ​​to 90% by mass, and more preferably 70% to 85% by mass, based on the total mass of the composition.

[0187] [Polyol] The composition according to the present invention may further contain at least one polyol. A single type of polyol may be used, or two or more different types of polyols may be used in combination.

[0188] The term "polyol" here refers to an alcohol having two or more hydroxyl groups and does not include sugars or their derivatives. Examples of sugar derivatives include sugar alcohols obtained by reducing one or more carbonyl groups of a sugar, and sugars or sugar alcohols in which one or more hydrogen atoms in the hydroxyl groups are replaced by at least one substituent such as an alkyl group, hydroxyalkyl group, alkoxy group, acyl group, or carbonyl group.

[0189] Polyols contain at least two hydroxyl groups, preferably two to five hydroxyl groups, C2-C 12 The polyol, preferably a C2-C9 polyol, may be used.

[0190] The polyol may be a natural polyol or a synthetic polyol. The polyol may have a linear, branched, or cyclic molecular structure.

[0191] Polyols can be selected from glycerols and their derivatives, and glycols and their derivatives. Polyols can be selected from the group consisting of glycerol, diglycerol, polyglycerol, ethylene glycol, diethylene glycol, propylene glycol, dipropylene glycol, butylene glycol, pentylene glycol, hexylene glycol, 1,3-propanediol, 1,5-pentanediol, polyethylene glycol (5 to 50 ethylene oxide groups), and sugars such as sorbitol.

[0192] The amount of polyol in the composition according to the present invention may be 0.01% by mass or more, preferably 0.05% by mass or more, and more preferably 0.1% by mass or more, based on the total mass of the composition.

[0193] On the other hand, the amount of polyol in the composition according to the present invention may be 25% by mass or less, preferably 20% by mass or less, and more preferably 15% by mass or less, based on the total mass of the composition.

[0194] Therefore, the polyol may be present in the composition according to the present invention in an amount ranging from 0.01% to 25% by mass, preferably 0.05% to 20% by mass, for example, 0.1% to 15% by mass, relative to the total mass of the composition.

[0195] [Other ingredients] The composition according to the present invention may contain one or more monohydric alcohols that are in liquid form at room temperature (25°C), such as linear or branched monohydric alcohols containing 1 to 6 carbon atoms, for example, ethanol, propanol, butanol, isopropanol, isobutanol, pentanol, and hexanol.

[0196] The amount of monohydric alcohol in the composition according to the present invention may be 0.01% by mass or more, preferably 0.1% by mass or more, and more preferably 1% by mass or more, based on the total mass of the composition.

[0197] On the other hand, the amount of monohydric alcohol in the composition according to the present invention may be 15% by mass or less, preferably 10% by mass or less, and more preferably 5% by mass or less, based on the total mass of the composition.

[0198] Therefore, the amount of monohydric alcohol in the composition according to the present invention may be in the range of 0.01% to 15% by mass, preferably 0.1% to 10% by mass, and more preferably 1% to 5% by mass, relative to the total mass of the composition.

[0199] The compositions according to the present invention may also contain, in addition to the components described above, various adjuvants conventionally used in cosmetic and dermatological compositions, such as anionic, nonionic, cationic, and amphoteric or zwitterionic polymers, anionic, nonionic, cationic, and amphoteric surfactants, thickeners, antioxidants, colorants, chelating agents, metal ion sequestering agents, fragrances, dispersants, conditioning agents, film-forming agents, preservatives, co-preservatives, and mixtures thereof.

[0200] The composition according to the present invention is anionic surfactant-free. The term "anionic surfactant-free" here means that the composition according to the present invention may contain anionic surfactant, but the amount of anionic surfactant is very limited, being 0.1% by mass or less, preferably 0.01% by mass or less, and more preferably 0.001% by mass or less, based on the total mass of the composition. It is most preferable that the composition according to the present invention is anionic surfactant-free.

[0201] In one embodiment, the composition according to the present invention may be free of polyoxyethylene-based nonionic surfactants. The term "free of" here means that the composition according to the present invention may contain polyoxyethylene-based nonionic surfactants, but the amount of polyoxyethylene-based nonionic surfactants is very limited, being 1% by mass or less, preferably 0.1% by mass or less, and more preferably 0.01% by mass or less, based on the total mass of the composition. It is most preferable that the composition according to the present invention is free of polyoxyethylene-based nonionic surfactants.

[0202] (preparation) The compositions according to the present invention can be prepared by mixing the essential components described above and, if necessary, the optional components described above.

[0203] The methods and means for mixing the above-mentioned essential and optional components are not limited. Any conventional methods and means can be used to mix the above-mentioned essential and optional components to prepare the compositions according to the present invention.

[0204] The compositions according to the present invention can be prepared without using the large amount of energy required by a homogenizer. Therefore, the compositions according to the present invention can be prepared using a small amount of energy, for example, by gently stirring the components of the composition. Thus, the compositions according to the present invention are environmentally friendly in terms of their preparation method.

[0205] [form] The composition according to the present invention is in the form of a nano or microemulsion.

[0206] The term "microemulsion" can be defined in two ways, namely in a broad sense and a narrow sense. Firstly, a microemulsion may refer to a thermodynamically stable, isotropic single liquid phase containing a three-component system having an oily component, an aqueous component, and a surfactant ("microemulsion in the narrow sense"). Secondly, among typical thermodynamically unstable emulsion systems, a microemulsion may further include emulsions that exhibit a transparent or translucent appearance due to their smaller particle size ("microemulsion in the broad sense") (Satoshi Tomomasa et al., Oil Chemistry, Vol. 37, No. 11 (1988), pp. 48-53). As used herein, "microemulsion" refers to a "microemulsion in the narrow sense," that is, a thermodynamically stable, isotropic single liquid phase.

[0207] A microemulsion refers to one of the following states: an O / W (oil-in-water) type microemulsion in which oil is solubilized by micelles, a W / O (water-in-oil) type microemulsion in which water is solubilized by reverse micelles, or a bicontinuous microemulsion in which the number of surfactant molecules that can aggregate becomes infinite, resulting in both the aqueous and oily phases having a continuous structure.

[0208] The microemulsion may have a dispersed phase with a particle size of 100 nm or less, preferably 50 nm or less, and more preferably 20 nm or less, as measured by laser particle size analysis.

[0209] Here, "nanoemulsion" refers to an emulsion characterized by a dispersed phase having a size of less than 350 nm, which is stabilized by a crown of nonionic surfactants (b)-(d) that can optionally form a lamellar-type liquid crystal phase at the dispersed phase / continuous phase interface. In the absence of certain opacifiers, the transparency of the nanoemulsion arises from the small size of the dispersed phase, which is achieved by the use of mechanical energy.

[0210] Nanoemulsions can be distinguished from microemulsions by their structure. Specifically, microemulsions are thermodynamically stable dispersions formed from micelles formed by components (b) and (c) and expanded with component (a). Furthermore, microemulsions require virtually no mechanical energy to prepare.

[0211] The nanoemulsion may have a dispersed phase having a particle size of 300 nm or less, preferably 200 nm or less, and more preferably 100 nm or less, as measured by laser particle size analysis.

[0212] The composition according to the present invention is preferably in the form of an O / W type emulsion containing an oil phase dispersed in a continuous aqueous phase. The dispersed oil phase may be oil droplets in the aqueous phase.

[0213] The O / W type composition or structure consists of an oil phase dispersed in an aqueous phase, with the aqueous phase on the outside. Therefore, when the composition according to the present invention has an O / W type composition or structure, it can provide a pleasant feeling of use due to the immediate freshness that the aqueous phase can provide.

[0214] (a) The particle size of the oil is preferably 300 nm or less, more preferably 200 nm or less, more preferably 100 nm or less, and even more preferably 50 nm or less. The particle size can be measured by dynamic light scattering. Particle size measurement can be performed, for example, by the ELSZ-2000 series particle size analyzer, which is commercially available from Otsuka Electronics Co., Ltd.

[0215] The particle size may be the volume-average particle diameter or the number-average particle diameter, preferably the volume-average particle diameter.

[0216] The composition according to the present invention may be transparent or slightly translucent.

[0217] Transparency can be measured by measuring turbidity (for example, turbidity can be measured using a 2100Q (commercially available from Hach Company) which has a round cell (25 mm in diameter and 60 mm in height) and a tungsten filament bulb capable of emitting visible light (between 400 nm and 800 nm, preferably 400-500 nm)). The measurement can be performed in an undiluted composition. A blank can be determined using distilled water.

[0218] The composition according to the present invention has a turbidity of 300 NTU or less, preferably 200 NTU or less, more preferably 100 NTU or less, and even more preferably 50 NTU or less.

[0219] [Usage and Instructions] The composition according to the present invention is preferably a cosmetic composition or a dermatological composition, preferably a cosmetic composition, and more preferably a cosmetic composition for keratinous substances such as skin.

[0220] The compositions according to the present invention can be used in non-therapeutic methods such as cosmetic methods for treating keratinous substances such as skin, hair, mucous membranes, nails, eyelashes, eyebrows, and / or scalp by applying them to keratinous substances.

[0221] Therefore, the present invention also relates to a cosmetic method for treating a keratinous substance, comprising the step of applying a composition according to the present invention to a keratinous substance.

[0222] The present invention may also relate to the use of compositions according to the present invention as or in cosmetics, such as care products for the skin of the body and / or face, and / or mucous membranes, and / or scalp, and / or hair, and / or nails, and / or eyelashes, and / or eyebrows.

[0223] In other words, the composition according to the present invention can be used as a cosmetic as is. Alternatively, the composition according to the present invention can be used as an element of a cosmetic. For example, the composition according to the present invention can be added to or combined with any other element to form a cosmetic.

[0224] Care products may include lotions and serums. [Examples]

[0225] The present invention will be described in more detail by reference to examples, but this should not be construed as limiting the scope of the invention.

[0226] (Example 1 and Comparative Examples 1 and 2) The following compositions, based on Example 1 and Comparative Examples 1-2 shown in Table 1, were prepared by mixing the components shown in Table 1 as follows.

[0227] The compositions of Example 1 and Comparative Examples 1-2 were in the form of O / W type emulsions.

[0228] The numerical values ​​for the amounts of the components shown in Table 1 are all based on the "mass %" of the raw materials.

[0229] [Table 1]

[0230] [evaluation] (Turbidity) The turbidity of the compositions from Example 1 and Comparative Examples 1-2 was measured at room temperature using a turbidimeter (2100Q portable, Hach Company).

[0231] The results are shown in Table 1 as "NTU". The smaller the NTU value, the more transparent the composition.

[0232] (particle size) The particle size (nm) of oil droplets in the compositions of Example 1 and Comparative Example 2 was measured using a particle size analyzer ELSZ-2000ZS (Otsuka Electronics Co., Ltd.).

[0233] The results are shown in Table 1.

[0234] The particle size of the oil droplets in the composition of Comparative Example 1 was not measured because the composition was opaque and clearly not in the form of nano or microemulsions.

[0235] Comparative Example 2 corresponds to Example 1 of WO 2020 / 110716.

[0236] Comparative Example 1 demonstrates that the formation of nano or microemulsions is inhibited by adding lactic acid and niacinamide to the composition according to Comparative Example 2.

[0237] Example 1 shows that when a combination of two different types of polyglycerol fatty acid esters is used at a mass ratio of "high HLB PG surfactant / low HLB PG surfactant" in the presence of a nonionic surfactant, where the amount of the polyglycerol fatty acid ester having a higher HLB value (the first polyglycerol fatty acid ester) / the amount of the polyglycerol fatty acid ester having a lower HLB value (the second polyglycerol fatty acid ester) (see reference in Table 1) is 3.0 or more, a nano or microemulsion can be formed.

[0238] (Examples 2-1 to 2-7) The following compositions according to Examples 2-1 to 2-7 shown in Table 2 were prepared by mixing the components shown in Table 2 as follows.

[0239] The compositions according to Examples 2-1 to 2-7 were in the form of O / W emulsions.

[0240] All numerical values of the amounts of the components shown in Table 2 are based on "mass %" of the raw materials.

[0241]

Table 2

[0242] [Evaluation] (Turbidity) The turbidity of the compositions according to Examples 2-1 to 2-7 was measured at room temperature using a turbidimeter (2100Q portable, Hach Company).

[0243] The results are shown in Table 2 as "NTU". The smaller the NTU value, the more transparent the composition.

[0244] (Particle size) The particle size (nm) of the oil droplets in the compositions according to Examples 2-1 to 2-7 was measured using a particle size analyzer ELSZ-2000ZS (Otsuka Electronics Co., Ltd.).

[0245] The results are shown in Table 2.

[0246] Examples 2-1 to 2-7 demonstrate that using the first and second polyglycerol fatty acid esters in a total amount of at least 0.05% by mass (see "Surfactant (%)" in Table 2) relative to the total mass of the composition can be effective in preparing nano or microemulsions.

[0247] (Examples 3-1 to 3-5 and Comparative Examples 3-1 to 3-6) The following compositions, based on Examples 3-1 to 3-5 and Comparative Examples 3-1 to 3-6 shown in Table 3, were prepared by mixing the components shown in Table 3 as follows.

[0248] The compositions from Examples 3-1 to 3-5 and Comparative Examples 3-1 to 3-6 were in the form of O / W type emulsions.

[0249] The numerical values ​​for the amounts of the components shown in Table 3 are all based on the "mass %" of the raw materials.

[0250] [Table 3A]

[0251] [Table 3B]

[0252] [evaluation] (Turbidity) The turbidity of the compositions prepared in Examples 3-1 to 3-5 and Comparative Examples 3-1 to 3-6 was measured at room temperature using a turbidimeter (2100Q portable, Hach Company).

[0253] The results are shown in Table 3 as "NTU". The smaller the NTU value, the more transparent the composition.

[0254] (particle size) The particle sizes (nm) of the oil droplets in the compositions according to Examples 3-1 to 3-5 were measured using a particle size analyzer ELSZ-2000ZS (Otsuka Electronics Co., Ltd.).

[0255] The results are shown in Table 3.

[0256] The particle sizes of the oil droplets in the compositions according to Comparative Examples 3-1 to 3-6 were not measured because the compositions were opaque and clearly not in the form of nano- or micro-emulsions.

[0257] Examples 3-1 to 3-5 show that when the mass ratio of the amount of oil / the total amount of the first and second polyglycerol fatty acid esters (see "oil / surfactant mass ratio" in Table 3) is 0.5 or less, nano- or micro-emulsions can be prepared.

[0258] Comparative Examples 3-1 to 3-6 show that when the mass ratio of the amount of oil / the total amount of the first and second polyglycerol fatty acid esters (see "oil / surfactant mass ratio" in Table 3) is 0.5 or more, nano- or micro-emulsions cannot be prepared.

[0259] (Examples 4-1 to 4-4 and Comparative Examples 4-1 to 4-6) The following compositions according to Examples 4-1 to 4-4 and Comparative Examples 4-1 to 4-6 shown in Table 4 were prepared by mixing the components shown in Table 4 as follows.

[0260] The compositions according to Examples 4-1 to 4-4 and Comparative Examples 4-1 to 4-6 were in the form of O / W type emulsions.

[0261] The numerical values of the amounts of the components shown in Table 4 are all based on "mass %" of the raw materials.

[0262]

Table 4A

[0263] [[ID=4l]]

Table 4B

[0264] [evaluation] (Turbidity) The turbidity of the compositions prepared in Examples 4-1 to 4-4 and Comparative Examples 4-1 to 4-6 was measured at room temperature using a turbidimeter (2100Q portable, Hach Company).

[0265] The results are shown in Table 4 as "NTU". The smaller the NTU value, the more transparent the composition.

[0266] (particle size) The particle size (nm) of oil droplets in the compositions prepared in Examples 4-1 to 4-4 was measured using a particle size analyzer ELSZ-2000ZS (Otsuka Electronics Co., Ltd.).

[0267] The results are shown in Table 4.

[0268] The particle size of oil droplets in the compositions of Comparative Examples 4-1 to 4-6 was not measured because the compositions were opaque and clearly not in the form of nano or microemulsions.

[0269] Examples 4-1 to 4-4 demonstrate that nano or microemulsions can be prepared when the mass ratio of the amount of the first polyglycerin fatty acid ester to the amount of the second polyglycerin fatty acid ester (see "high HLB PG surfactant / low HLB PG surfactant" in Table 4) is 3.0 or higher.

[0270] Comparative Examples 4-1 to 4-4 demonstrate that nano or microemulsions cannot be prepared when the mass ratio of the amount of the first polyglycerin fatty acid ester to the amount of the second polyglycerin fatty acid ester (see "high HLB PG surfactant / low HLB PG surfactant" in Table 4) is less than 3.0.

[0271] (Examples 5-1 to 5-11) The following compositions, according to Examples 5-1 to 5-11 shown in Table 5, were prepared by mixing the components shown in Table 5 as follows.

[0272] The compositions according to Examples 5-1 to 5-11 were in the form of O / W type emulsions.

[0273] The numerical values ​​for the amounts of the components shown in Table 5 are all based on the "mass %" of the raw materials.

[0274] [Table 5A]

[0275] [Table 5B]

[0276] [evaluation] (Turbidity) The turbidity of the compositions prepared in Examples 5-1 to 5-11 was measured at room temperature using a turbidimeter (2100Q portable, Hach Company).

[0277] The results are shown in Table 5 as "NTU". The smaller the NTU value, the more transparent the composition.

[0278] (particle size) The particle size (nm) of oil droplets in the compositions prepared in Examples 5-1 to 5-11 was measured using a particle size analyzer ELSZ-2000ZS (Otsuka Electronics Co., Ltd.).

[0279] The results are shown in Table 5.

[0280] Examples 5-1 to 5-9 demonstrate that the use of lactic acid in an amount of at least 0.1% to 10% by mass, and the use of niacinamide in an amount of 0.1% to 20% by mass, can be effective in preparing nano or microemulsions.

[0281] Examples 5-10 and 5-11 demonstrate that lactic acid and niacinamide can be used individually.

[0282] (Examples 6-1 to 6-10) The following compositions, according to Examples 6-1 to 6-10 shown in Table 6, were prepared by mixing the components shown in Table 6 as follows.

[0283] The compositions according to Examples 6-1 to 6-10 were in the form of O / W type emulsions.

[0284] The numerical values ​​for the amounts of the components shown in Table 6 are all based on the "mass %" of the raw materials.

[0285] [Table 6A]

[0286] [Table 6B]

[0287] [evaluation] (Turbidity) The turbidity of the compositions prepared in Examples 6-1 to 6-11 was measured at room temperature using a turbidimeter (2100Q portable, Hach Company).

[0288] The results are shown in Table 6 as "NTU". The smaller the NTU value, the more transparent the composition.

[0289] (particle size) The particle size (nm) of oil droplets in the compositions prepared in Examples 6-1 to 6-10 was measured using a particle size analyzer ELSZ-2000ZS (Otsuka Electronics Co., Ltd.).

[0290] The results are shown in Table 6.

[0291] Examples 6-1 to 6-10 demonstrate that nano or microemulsions can be prepared at a pH of at least 3.5 to 9.0.

Claims

1. (a) at least one type of oil, (b) Polyglyceryl-4 caprate, (c) Polyglyceryl-2 oleate, (d) at least one active ingredient for skin care selected from vitamin B3, alpha-hydroxy acids and mixtures thereof, (e) water and A composition in the form of a nano or microemulsion containing, (b) The mass ratio of polyglyceryl-4 caprate to (c) polyglyceryl-2 oleate is 3.0 or greater. (a) The mass ratio of the amount of oil to the total amount of (b) polyglyceryl-4 caprate and (c) polyglyceryl-2 oleate is 0.5 or less. The composition contains 0.1% by mass or less of an anionic surfactant. composition.

2. The composition according to claim 1, having a turbidity of 300 NTU or less.

3. (a) The composition according to claim 1 or 2, wherein the oil is selected from polar oils.

4. The composition according to any one of claims 1 to 3, wherein the amount of (a) oil in the composition is in the range of 10% by mass or less with respect to the total mass of the composition.

5. The composition according to any one of claims 1 to 4, wherein the amount of (b) polyglyceryl-4 caprate in the composition is in the range of 0.01% by mass to 15% by mass or less, relative to the total mass of the composition.

6. The composition according to any one of claims 1 to 5, wherein the amount of (c) polyglyceryl-2 oleate in the composition is in the range of 0.01% by mass to 10% by mass or less, relative to the total mass of the composition.

7. The composition according to any one of claims 1 to 6, wherein the total amount of (b) polyglyceryl-4 caprate and (c) polyglyceryl-2 oleate is 0.05% by mass or more with respect to the total mass of the composition.

8. (d) The composition according to any one of claims 1 to 7, wherein the skincare active ingredient is selected from the group consisting of lactic acid, niacinamide, and mixtures thereof.

9. (d) The composition according to any one of claims 1 to 8, wherein the amount of the skincare active ingredient is 0.01% by mass to 25% by mass with respect to the total mass of the composition.

10. The composition according to any one of claims 1 to 9, wherein the pH of the composition is 3.5 to 9.

0.

11. The composition according to any one of claims 1 to 10, in the form of a nano or micro O / W emulsion.

12. (a) The composition according to claim 11, wherein the particle size of the oil is 300 nm or less.

13. A cosmetic method for treating a keratin substance, comprising the step of applying a composition according to any one of claims 1 to 12 to the keratin substance.

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