Glycosylated ComP pyrine variant, method of manufacture, and use thereof

JP7892938B2Inactive Publication Date: 2026-07-22VAXNEWMO LLC
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Patent Information

Authority / Receiving Office
JP · JP
Patent Type
Patents
Current Assignee / Owner
VAXNEWMO LLC
Filing Date
2019-06-14
Publication Date
2026-07-22
Estimated Expiration
Not applicable · inactive patent

AI Technical Summary

Technical Problem

Current pneumococcal conjugate vaccines face challenges in chemical synthesis with low yields, batch-to-batch variability, and the need for improved methods to conjugate Streptococcus pneumoniae membrane polysaccharides to proteins efficiently, as existing oligosaccharide transferases (OTases) like PglB and PglL are not effective for glucose-containing CPS serotypes.

Method used

Development of bioconjugates using a ComP protein or its glycosylated tag fragments covalently bound to oligosaccharides or polysaccharides, utilizing PglS OTase for in vivo conjugation in bacterial cells, particularly with PglS ADP1, to efficiently link pneumococcal polysaccharides to carrier proteins.

Benefits of technology

This approach enables efficient and specific conjugation of pneumococcal polysaccharides to carrier proteins, potentially reducing production costs and improving vaccine efficacy by inducing serotype-specific immune responses.

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Abstract

Provided herein are glycosylated ComP proteins, fragments and fusion proteins thereof, and methods of production for use, for example, in the production of conjugate vaccines. Also provided herein are conjugate vaccines against diseases, including bacterial diseases.
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