Disinfectant composition

Abstract

Provided is a disinfectant composition that exhibits excellent long-term benzalkonium chloride stability and excellent adherence to articles.　The present invention relates to a disinfectant composition having a pH from 6.0 to 7.0 and containing the following components (A) to (D). (A) 0.06 mass% to 0.2 mass% of benzalkonium chloride; (B) 0.005 mass% to 0.2 mass% of parabens; (C) 5 mass% to 30 mass% of ethanol; and (D) at least 0.3 mM but less than 10 mM of a pH buffer.

Description

Disinfectant Composition

[0001] The present invention relates to a disinfectant composition that can provide a long-term disinfecting effect to various objects to be disinfected.

[0002] Hygiene consciousness has increased in living environments, business environments, restaurant environments, store environments, etc., and hygiene consciousness is increasing not only for human hands but also for doorknobs, desks, chairs, various tools and instruments, tables, tableware, glasses, mobile phones, kitchens, living rooms, toilets, bathrooms, washrooms, car interiors, textile products, clothing, etc. In addition, the global spread of the new coronavirus and new strains of influenza has become a major factor, and there is a desire to easily inactivate not only bacteria and fungi such as mold, but also various viruses, and to make items surrounding the living environment antibacterial and antiviral, thereby reducing the risk of infection and secondary infection.

[0003] Numerous disinfectants, including liquid, spray, and sheet disinfectants, are commercially available for these items and human hands. Their active ingredients include ethanol, benzalkonium chloride, cetylpyridinium chloride, phenoxyethanol, silver ions, isopropylmethylphenol, and sodium benzoate. Of these, benzalkonium chloride has a high antibacterial effect and is widely used in pharmaceuticals and quasi-drugs (Various Disinfectants and Non-Patent Document 1). Benzalkonium chloride is also used in deodorant compositions (Patent Document 1) and acne treatments (Patent Document 2).

[0004] JP 2015-199712 A JP 2007-308430 A

[0005] Pharmaceutical Interview Form Oronine Topical Solution 10% (2008)

[0006] Unless the active ingredient adheres stably for a long period of time to the surface of an article to which a disinfectant has been applied, the effect of the disinfectant cannot be stably obtained. Therefore, an object of the present invention is to provide a disinfectant composition in which the disinfecting active ingredient, particularly benzalkonium chloride, has good long-term stability and adheres well to the object to be disinfected.

[0007] Therefore, the present inventors mixed various ingredients with benzalkonium chloride and investigated the adhesion of the resulting composition to the object to be disinfected and the long-term stability of its properties. As a result, they found that by mixing specific amounts of benzalkonium chloride, parabens, ethanol, and a pH buffer and adjusting the pH of the composition to 6.0 to 7.0, a disinfectant composition can be obtained that dries quickly and has good long-term stability of benzalkonium chloride and good adhesion to the object to be disinfected, thereby completing the present invention.

[0008] That is, the present invention provides the following inventions [1] to [8]. [1] A disinfectant composition containing the following components (A) to (D) and having a pH of 6.0 to 7.0: (A) benzalkonium chloride 0.06% by mass or more and 0.2% by mass or less, (B) parabens 0.005% by mass or more and 0.2% by mass or less, (C) ethanol 5% by mass or more and 30% by mass or less, and (D) a pH buffer 0.3 mM or more and less than 10 mM. [2] The disinfectant composition according to [1], wherein the parabens are one or more selected from methylparaben, ethylparaben, propylparaben, and butylparaben. [3] The disinfectant composition according to [1] or [2], wherein the pH buffer is one or more selected from citric acid, malic acid, tartaric acid, triethanolamine, diethanolamine, succinic acid, fumaric acid, maleic acid, trishydroxymethylaminomethane, lactic acid, phosphoric acid, boric acid, and salts thereof. [4] The disinfectant composition according to any of [1] to [3], further containing (E) phenoxyethanol. [5] The disinfectant composition according to [4], wherein the content of (E) phenoxyethanol is 0.01% by mass or more and 1% by mass or less. [6] The disinfectant composition according to any of [1] to [5], which is a disinfectant solution composition. [7] The disinfectant composition according to any of [1] to [5], which is a disinfectant composition for use on articles. [8] The disinfectant composition according to any of [1] to [7], which is in the form of a sheet or a spray. [9] The disinfectant composition according to any of [1] to [8], wherein the pH buffer is citric acid or a salt thereof.

[10] The disinfectant composition according to any one of [1] to [9], which is a disinfectant solution-containing spray for use on items.

[0009] According to the present invention, a disinfectant composition can be provided in which benzalkonium chloride has good long-term stability, dries quickly on the items to be disinfected (hereinafter also referred to as items, etc.), has excellent adhesion to the items, and can maintain its disinfecting effect on the items, etc. for a long period of time.

[0010] The disinfectant composition of the present invention contains specific amounts of (A) benzalkonium chloride, (B) parabens, (C) ethanol, and (D) a pH buffer. Component (A) benzalkonium chloride is known to have a bactericidal effect against fungi, gram-positive bacteria, and gram-negative bacteria. Its mechanism of action is to denature proteins on the surface of bacterial cell membranes, thereby inactivating them, and this action functions as the bactericidal and disinfecting effect. Benzalkonium chloride is also known to detoxify viruses by acting on their membranes (Ministry of Health, Labour and Welfare website). The disinfecting effect of benzalkonium chloride is due to its antibacterial and antiviral effects, and the disinfecting effect of the present invention includes antibacterial, disinfecting, antiviral, and viral removal effects. The content of component (A) in the disinfectant composition of the present invention is preferably 0.06% by mass or more and 0.2% by mass or less, from the viewpoints of disinfecting effect, adhesion to objects, etc., and long-term stability. The content of component (A) is more preferably 0.08% by mass or more and 0.2% by mass or less, and even more preferably 0.1% by mass or more and 0.2% by mass or less.

[0011] Component (B) parabens are typically used as preservatives, but in the present invention, they not only contribute to the long-term stability of the composition but also particularly contribute to improving the adhesion of benzalkonium chloride to articles, etc. Among various preservatives, parabens are particularly effective in improving the adhesion of benzalkonium chloride to articles, etc. Examples of parabens include methylparaben (methyl parahydroxybenzoate), ethylparaben (ethyl parahydroxybenzoate), propylparaben (propyl parahydroxybenzoate), and butylparaben (butyl parahydroxybenzoate), and one or more selected from these may be used. The content of component (B) in the disinfectant composition of the present invention is preferably 0.005% by mass or more and 0.2% by mass or less from the viewpoints of disinfecting activity, improved adhesion to articles, etc., and long-term stability. The content of component (B) is more preferably 0.01% by mass or more and 0.2% by mass or less, and even more preferably 0.05% by mass or more and 0.2% by mass or less.

[0012] The mass ratio (A / B) of component (A) to component (B) in the disinfectant composition of the present invention is preferably 0.5 or more and 20 or less, more preferably 0.5 or more and 10 or less, even more preferably 0.5 or more and 5 or less, and even more preferably 0.5 or more and 4 or less, from the viewpoint of excellent effect of improving adhesion to articles, etc.

[0013] Component (C) ethanol not only functions as a solvent for components (A) and (B), but also maintains the long-term stability of the composition and, after application to an article or the like, quickly volatilizes, thereby allowing components (A) and (B) to remain attached to the surface of the article or the like. The content of component (C) in the disinfectant composition of the present invention is preferably 5% by mass or more and 30% by mass or less from the viewpoints of disinfecting action, improved adhesion to articles or the like, no denaturation of the article surface, drying speed, long-term stability of the composition, and irritation. If the content of component (C) exceeds 30% by mass, the quick-drying property of the composition is improved, but the surface of the article to be disinfected may be denatured. Furthermore, the content of component (C) is more preferably 5% by mass or more and 25% by mass or less, and even more preferably 5% by mass or more and 20% by mass or less.

[0014] The pH buffer of component (D) not only adjusts the pH of the composition, but also contributes to the long-term stability of the composition and the improvement of the adhesion of component (A). Specific examples of the pH buffer of component (D) include one or more selected from citric acid, malic acid, tartaric acid, triethanolamine, diethanolamine, succinic acid, fumaric acid, maleic acid, trishydroxymethylaminomethane, lactic acid, phosphoric acid, boric acid, and salts thereof. From the viewpoint of the effect of improving the adhesion of component (A), one or more selected from citric acid, malic acid, tartaric acid, succinic acid, fumaric acid, lactic acid, and salts thereof are preferred, one or more selected from citric acid, malic acid, tartaric acid, lactic acid, and salts thereof are more preferred, and one or more selected from citric acid and salts thereof are even more preferred. Here, the salt is preferably an alkali metal salt, and more preferably a sodium salt. From the viewpoint of improving the long-term stability of the composition and the adhesion of component (A), the content of component (D) in the disinfectant composition of the present invention is preferably 0.3 mM or more and less than 10 mM, more preferably 0.5 mM or more and less than 10 mM, more preferably 1 mM or more and less than 10 mM, and even more preferably 2 mM or more and less than 10 mM.

[0015] The pH of the disinfectant composition of the present invention is preferably 6.0 to 7.0 from the viewpoint of long-term stability of the composition and improving the adhesion of component (A). The pH is more preferably 6.0 to 6.8, and even more preferably greater than 6.0 but not greater than 6.8. The pH is preferably adjusted using component (D).

[0016] In addition to the above components, the disinfectant composition of the present invention can contain antiseptic and bactericidal components such as cetylpyridinium chloride, phenoxyethanol, silver ions, isopropylmethylphenol, and sodium benzoate. Among these antiseptic and bactericidal components, the inclusion of (E) phenoxyethanol is preferred from the viewpoints of maintaining the bactericidal and disinfecting action, ensuring the long-term stability of the composition, and ensuring the adhesion-improving effect of component (A). The content of (E) phenoxyethanol in the disinfectant composition of the present invention is preferably 0.01% by mass or more to 1% by mass, more preferably 0.1% by mass or more to 1% by mass, and even more preferably 0.3% by mass or more to 1% by mass, from the viewpoints of maintaining the bactericidal and disinfecting action, ensuring the long-term stability of the composition, and ensuring the adhesion-improving effect of component (A).

[0017] In addition to the above-mentioned components, the disinfectant composition of the present invention may contain water, a cooling agent such as menthol, a plant extract such as green tea extract or persimmon tannin, etc. Furthermore, from the viewpoint of the adhesion of component (A) to articles and the like, it is preferable that the composition is substantially free of surfactants such as polyhydric alcohols such as glycerin, propylene glycol, 1,3-butylene glycol, pentylene glycol, and sorbitol, anionic polymers such as carboxyvinyl polymers, silicones, glycerin fatty acid esters, polyoxyethylene hydrogenated castor oil, polyoxyethylene isocetyl ether, polyoxyethylene behenyl ether, and N-cocoyl acyl-L-arginine ethyl-DL-pyrrolidone carboxylate. In particular, from the viewpoint of the adhesion of component (A) to articles and the like, it is preferable that the composition is substantially free of surfactants. Here, "substantially free" means that the content is less than 0.1% by mass or that the component is not present at all.

[0018] The disinfectant composition of the present invention is preferably in a non-viscous liquid form, since the effects of the present invention are achieved when the composition is in a uniform liquid form, and the composition remains effectively when sprayed onto an object or the like and dries quickly.

[0019] The disinfectant composition of the present invention contains the disinfecting component benzalkonium chloride, as described above, and is stable for a long period of time and has excellent adhesion to articles, etc., making it useful as a disinfectant for various articles. Here, the disinfecting action includes, as described above, antibacterial action, disinfecting action, antiviral action, and antiviral action. The article may be any article other than the human body that requires disinfection, such as an article present in a living environment, a corporate work environment, a restaurant environment, a store environment, a medical environment, etc. Specific examples of the article include furniture such as doorknobs, desks, chairs, and tables, various tools and instruments, tableware, glasses, mobile phones, kitchens, living rooms, toilets, bathrooms, washrooms, car interiors, textile products, clothing, medical instruments, surgical instruments, etc.

[0020] As described above, the disinfectant composition of the present invention is preferably in a form that can be applied to an article or the like, for example, a sheet or spray impregnated with a liquid composition is preferred, and a spray is more preferred because of the convenience of being able to use the composition without waste. The spray may be either a pump-type spray or an aerosol. The disinfectant composition in these forms can be used to disinfect an article or the like by adhering the composition to the article.

[0021] The present invention will now be described in more detail with reference to examples, but the present invention is not limited to these examples.

[0022] Examples 1 to 22 and Comparative Examples 1 to 18 The components shown in Tables 1 to 4 were mixed to obtain uniform liquid compositions.

[0023] (1) Adhesion test (benzalkonium chloride adhesion to centrifuge tubes) A. Accurately place 2 mL of each sample into a centrifuge tube, and leave it in an 80°C incubator with the tube upright and open to dry completely. B. Slowly add 5 mL of purified water to the dried centrifuge tube from the wall of the tube, then shake for 1 minute on a shaker (shaking speed 100 rpm). C. After shaking on a shaker, accurately place 1 mL of each sample into a measuring flask, and add purified water to dilute 50 times. D. Quantify the amount of benzalkonium chloride in the 50-fold diluted solution using HPLC. Evaluation criteria (benzalkonium chloride residual rate) ◎: Residual rate 90% or more 〇: Residual rate 70% or more but less than 90% △: Residual rate 50% or more but less than 70% ×: Residual rate less than 50%

[0024] (2) Stability test The appearance (presence or absence of precipitates) of the composition was visually evaluated immediately after production and after one week of storage in a cool place (about 5°C). Evaluation criteria: ◯: No precipitates were observed; △: Transparency appears to have decreased slightly, but almost no change was discernible; ×: Precipitates were observed.

[0025] (3) Effect on the surface of the sprayed article 0.75 mL of the liquid composition was sprayed onto the surface of a black resin plate, and it was observed whether crystals of the components were precipitated on the surface of the resin plate.

[0026] (4) Drying speed of liquid composition sprayed on the surface of an article 0.1 mL of the liquid composition was sprayed onto the surface of a grooved resin plate (7.5 cm × 14 cm), spread so as not to form pools, and then left in a thermostatic chamber at 25°C. The drying state was visually confirmed to evaluate the drying speed on the surface. By this method, drying within 5 minutes was evaluated as fast, and drying taking more than 5 minutes was evaluated as slow.

[0027] (5) Antibacterial test 1 mL of the test sample was dropped onto a polyethylene plate and dried, and 0.4 mL of bacterial solution (Staphylococcus aureus, approximately 400,000 cells / mL) was placed on top of it and allowed to come into contact with it for 5 minutes. At the same time, 0.4 mL of bacterial solution was placed on an untreated polyethylene plate. Each bacterial solution was cultured on a medium and the bacterial reduction rate was measured. Bacterial reduction rate ○: 99.9% or more △: 99.0% or more but less than 99.9% ×: Less than 99.0%

[0028] The evaluation results are shown in Tables 1 to 4. Tables 1 to 4 show that disinfectant compositions containing (A) 0.06% by mass or more and 0.2% by mass or less of benzalkonium chloride, (B) 0.005% by mass or more and 0.2% by mass or less of parabens, (C) 5% by mass or more and 30% by mass or less of ethanol, and (D) 0.3 mM or more and less than 10 mM of a pH buffer and having a pH of 6.0 to 7.0 have excellent long-term stability and excellent adhesion to the surface of articles.

[0029]

[0030]

[0031]

[0032]

Claims

1. A disinfectant composition containing the following components (A) to (D) and having a pH of 6.0 to 7.0: (A) benzalkonium chloride 0.06% by mass or more and 0.2% by mass or less, (B) Parabens 0.005% by mass or more and 0.2% by mass or less, (C) ethanol 5% by mass or more and 30% by mass or less, and (D) pH buffer: 0.3 mM or more and less than 10 mM

2. 2. The disinfectant composition according to claim 1, wherein the parabens are one or more selected from the group consisting of methylparaben, ethylparaben, propylparaben and butylparaben.

3. 2. The disinfectant composition according to claim 1, wherein the pH buffer is one or more selected from the group consisting of citric acid, malic acid, tartaric acid, triethanolamine, diethanolamine, succinic acid, fumaric acid, maleic acid, trishydroxymethylaminomethane, lactic acid, phosphoric acid, boric acid, and salts thereof.

4. The disinfectant composition according to claim 1, further comprising (E) phenoxyethanol.

5. The disinfectant composition according to claim 4, wherein the content of (E) phenoxyethanol is 0.01% by mass or more and 1% by mass or less.

6. The disinfectant composition according to any one of claims 1 to 5, which is a disinfectant liquid composition.

7. The disinfectant composition according to any one of claims 1 to 5, which is a disinfectant composition for articles.

8. The disinfectant composition according to any one of claims 1 to 5, which is in the form of a sheet or a spray.

9. The disinfectant composition according to any one of claims 1 to 5, wherein the pH buffer is citric acid or a salt thereof.

10. The disinfectant composition according to any one of claims 1 to 5, which is a spray containing a disinfectant solution for use on articles.