Radioactive drug distribution system and radioactive drug distribution method using the same

Abstract

A radioactive drug distribution system and a method for distributing a radioactive drug using the same are provided. A radioactive drug distribution system according to one aspect of the present invention is a radioactive drug distribution system for distributing a solution in which a radioactive drug stored in a source container and a diluent stored in a delusion container are mixed, comprising: a first syringe; a second syringe; a first manifold comprising a source valve for controlling the fluid flow of a source channel communicating with the source container, a delusion valve for controlling the fluid flow of a delusion channel communicating with the delusion container, a first syringe valve for controlling the fluid flow of a first syringe channel communicating with the first syringe, and a second syringe valve for controlling the fluid flow of a second syringe channel communicating with the second syringe; and a second manifold located downstream of the first manifold, comprising a first distribution valve communicating with a first distribution channel for distributing the solution to a first distribution container.

Description

Technology Field

[0001] The present invention relates to a radioactive drug distribution system and a radioactive drug distribution method using the same, and more specifically, provides a radioactive drug distribution system capable of distributing low and high doses of radioactive drugs using a single system and a radioactive drug distribution method using the same. Background Technology

[0003] In the medical field, radioactive drugs play an essential role in diagnosing and treating specific tumors. In particular, Iodine-131 meta-iodobenzylguanidine (hereinafter “mIBG”) is a representative radioactive drug widely used in the diagnosis and treatment of neuroendocrine tumors and has established itself as an effective treatment option for a diverse range of patients, including those with pediatric cancer.

[0004] However, the required amount of radioactivity for I-131 mIBG varies significantly depending on the application (diagnosis or treatment). For diagnostic purposes, a small amount, such as 1 to 3 mCi, is generally used, but for treatment, a high dose of up to 200 mCi is required. Due to this difference in dose, separate distribution processes must be established at production sites for each dose, and the issue of increased radiation exposure to workers during this process has been continuously raised.

[0005] In particular, the risk of radiation exposure increases as the time a worker directly handles the radioactive drug during the distribution process lengthens. Conventionally, attempts were made to reduce radiation exposure by wearing lead gloves and stacking lead bricks (shielding bricks) in front of the chest, but this method had limitations in that it reduced process efficiency and increased the burden on workers.

[0006] For materials with a very wide dosage range, such as I-131 mIBG, from 1 mCi to 200 mCi, productivity was low and the working environment was complex because small-batch and large-batch dispensing were operated as separate devices or processes. This resulted in limitations on mass production, and it became increasingly difficult to ensure worker safety as manual processes increased.

[0007] Furthermore, for patients with neuroendocrine tumors, particularly pediatric cancer patients with limited treatment options, I-131 mIBG must be reliably supplied at appropriate doses at the necessary times. However, scaling up production has been difficult due to the complexity of the dispensing process and concerns regarding worker radiation exposure. Consequently, there is an urgent need for technology that enables mass production while enhancing workplace safety and systematically managing radiation exposure by achieving automation and efficiency in the dispensing process.

[0008] To solve these problems, the present invention proposes a radioactive drug distribution system designed to distribute I-131 mIBG of various doses ranging from 1 mCi to 200 mCi in a single system, and a radioactive drug distribution method using the same.

[0009] Through this, by reducing workers' radiation exposure time throughout the production process and establishing an automated system capable of mass production, it is possible to simultaneously resolve the issues of dose handling limitations and reduced safety inherent in conventional radioactive drug dispensing processes. The problem to be solved

[0011] The present invention is intended to solve the above-mentioned problems, and the objective of the present invention is to provide a radioactive drug distribution system and a radioactive drug distribution method using the same.

[0012] Another objective of the present invention is to provide a radioactive drug distribution system capable of dispensing low and high doses of radioactive drugs in a single system, and a radioactive drug distribution method using the same.

[0013] The problems of the present invention are not limited to those mentioned above, and other unmentioned problems will be clearly understood by a person skilled in the art to which the present invention pertains from the description below. means of solving the problem

[0015] According to one aspect of the present invention, a radioactive drug dispensing system for dispensing a solution in which a radioactive drug stored in a source container and a diluent stored in a delusion container are mixed is provided, comprising: a first syringe; a second syringe; a first manifold comprising a source valve for controlling the fluid flow of a source channel communicating with the source container, a delusion valve for controlling the fluid flow of a delusion channel communicating with the delusion container, a first syringe valve for controlling the fluid flow of a first syringe channel communicating with the first syringe, and a second syringe valve for controlling the fluid flow of a second syringe channel communicating with the second syringe; and a second manifold located downstream of the first manifold, comprising a first distribution valve communicating with a first distribution channel for dispensing the solution to a first distribution container.

[0016] A radioactive drug dispensing system may be provided, wherein the first manifold further comprises a first manifold flow path fluidically connecting the source valve, the delusion valve, the first syringe valve, and the second syringe valve, wherein the source valve controls the connection state between the first manifold flow path and the source flow path while in communication with the first manifold flow path, the delusion valve controls the connection state between the first manifold flow path and the delusion flow path while in communication with the first manifold flow path, the first syringe valve controls the connection state between the first syringe flow path and the source flow path while in communication with the first manifold flow path, and the second syringe valve controls the connection state between the second syringe flow path and the source flow path while in communication with the first manifold flow path.

[0017] At this time, when the first syringe valve opens the first syringe flow path and the source valve opens the source flow path, a radioactive drug dispensing system may be provided in which the first syringe draws the radioactive drug stored in the source container toward the first syringe.

[0018] At this time, when the first syringe valve opens the first syringe path and the dilution valve opens the dilution path, the first syringe draws the diluent stored in the dilution container toward the first syringe, and the radioactive drug and the diluent are mixed within the first syringe, a radioactive drug dispensing system may be provided.

[0019] At this time, when the second syringe valve opens the second syringe flow path and the source valve opens the source flow path, a radioactive drug dispensing system may be provided in which the second syringe draws the radioactive drug stored in the source container into the second syringe side.

[0020] At this time, when the second syringe valve opens the first syringe path and the dilution valve opens the dilution path, the second syringe draws the diluent stored in the dilution container toward the second syringe side, and the radioactive drug and the diluent are mixed within the second syringe, a radioactive drug dispensing system may be provided.

[0021] At this time, a radioactive drug dispensing system may be provided, wherein the radioactive drug and the diluent are mixed in the first syringe and the second syringe, and the radioactive drug and the diluent are mixed at different concentrations in the first syringe and the second syringe.

[0022] At this time, a radioactive drug distribution system may be provided, wherein the second manifold further comprises a second distribution valve communicating with a second distribution channel that distributes the solution to a second distribution container.

[0023] At this time, a radioactive drug distribution system may be provided, wherein the second manifold further comprises a plurality of distribution valves communicating with a plurality of distribution channels that distribute the solution to a plurality of distribution containers, respectively.

[0024] At this time, a radioactive drug distribution system may be provided in which the second manifold is provided in multiple numbers, and each of the second manifolds communicates independently with the first manifold.

[0025] At this time, a radioactive drug distribution system may be provided, wherein a drainage channel is provided downstream of the second manifold to drain the solution that is not distributed but passes through the first manifold and the second manifold.

[0026] At this time, a radioactive drug dispensing system may be provided, further comprising a first pump that applies pressure to one side; wherein the first manifold further comprises a positive pressure valve that controls the fluid flow of a first positive pressure path communicating with the first pump.

[0027] At this time, a radioactive drug distribution system may be provided, further comprising a second pump that communicates with a second positive pressure channel branched from the first positive pressure channel and applies a higher pressure than the first pump to one side.

[0028] At this time, a radioactive drug dispensing system may be provided, further comprising a radioactivity sensor capable of measuring the amount of radioactivity detected from the radioactive drug stored in the source container.

[0029] At this time, a radiation dose sensor capable of confirming whether radioactive drugs remain in the drainage channel may be further included.

[0030] At this time, a distance sensor capable of measuring the change in distance of the first syringe end portion may be further included.

[0031] According to another aspect of the present invention, a method for dispensing a radioactive drug using a radioactive drug dispensing system according to any one of claims 1 to 14 is provided, the method further comprising: a dispensing amount determination step for determining a required amount of radioactive drug; a drug extraction step for extracting the radioactive drug and storing it in the first syringe or the second syringe; a drug dilution step for mixing the radioactive drug with the diluent; and a drug dispensing step for dispensing a solution in which the radioactive drug and the diluent are mixed.

[0032] At this time, a method for dispensing a radioactive drug may be provided, wherein the dispensing amount determination step comprises: a target amount verification step for verifying the required amount of radioactive drug according to the purpose of use; a dilution amount calculation step for calculating the dilution amount according to the required amount of radioactive drug; and a syringe selection step for selecting a first syringe or a second syringe according to the required amount of radioactive drug. Effects of the invention

[0034] According to the above configuration, a radioactive drug distribution system and a radioactive drug distribution method using the same according to one aspect of the present invention can distribute a radioactive drug.

[0035] A radioactive drug distribution system and a radioactive drug distribution method using the same according to another aspect of the present invention can distribute low and high doses of radioactive drugs in a single system.

[0036] The effects of the present invention are not limited to the effects described above, and should be understood to include all effects that can be inferred from the configuration of the invention described in the detailed description or claims of the present invention. Brief explanation of the drawing

[0038] FIG. 1 is a drawing illustrating a radioactive drug distribution system according to one embodiment of the present invention. FIG. 2 is a diagram illustrating the first syringe and the source container communicating in a radioactive drug dispensing system according to one embodiment of the present invention. FIG. 3 is a diagram illustrating the first syringe and the delusion container communicating in a radioactive drug dispensing system according to one embodiment of the present invention. FIG. 4 is a diagram illustrating the state in which the mixing of the radioactive drug and the diluent is completed within the first syringe in a radioactive drug dispensing system according to one embodiment of the present invention. FIG. 5 is a diagram illustrating the distribution of a mixed solution of a radioactive drug and a diluent from a first syringe to a first distribution container in a radioactive drug distribution system according to one embodiment of the present invention. FIG. 6 is a diagram illustrating the completion of distribution of a mixed solution of a radioactive drug and a diluent from a first syringe to a first distribution container in a radioactive drug distribution system according to one embodiment of the present invention. FIG. 7 is a diagram illustrating the filling of a diluent into a first syringe for the recovery of a mixed solution within a radioactive drug distribution system according to one embodiment of the present invention. FIG. 8 is a diagram illustrating the recovery of a mixed solution to a drainage container using a first syringe and a first pump of a radioactive drug distribution system according to one embodiment of the present invention. FIG. 9 is a diagram illustrating the recovery of a mixed solution to a drainage container using a first pump of a radioactive drug distribution system according to one embodiment of the present invention. FIG. 10 is a diagram illustrating the second syringe and the source container communicating in a radioactive drug dispensing system according to one embodiment of the present invention. FIG. 11 is a drawing illustrating the second syringe and the delusion container communicating in a radioactive drug dispensing system according to one embodiment of the present invention. FIG. 12 is a diagram illustrating the state in which the mixing of the radioactive drug and the diluent is completed within the second syringe in a radioactive drug dispensing system according to one embodiment of the present invention. FIG. 13 is a diagram illustrating the distribution of a mixed solution of a radioactive drug and a diluent from a second syringe to a second distribution container in a radioactive drug distribution system according to one embodiment of the present invention. FIG. 14 is a diagram illustrating the completion of distribution of a mixed solution of a radioactive drug and a diluent from a second syringe to a second distribution container in a radioactive drug distribution system according to one embodiment of the present invention. FIG. 15 is a diagram illustrating the filling of a diluent into a second syringe for the recovery of a mixed solution within a radioactive drug distribution system according to one embodiment of the present invention. FIG. 16 is a diagram illustrating the recovery of a mixed solution to a drainage container using a second syringe and a first pump of a radioactive drug distribution system according to one embodiment of the present invention. FIG. 17 is a diagram illustrating the recovery of a mixed solution to a drainage container using a first pump of a radioactive drug distribution system according to one embodiment of the present invention. FIG. 18 is a diagram illustrating the recovery of a mixed solution to a drainage container using a first pump of a radioactive drug distribution system according to one embodiment of the present invention. FIG. 19 is a flowchart illustrating a radioactive drug dispensing method according to one embodiment of the invention. FIG. 20 is a flowchart illustrating in detail the step of determining the distribution amount of a radioactive drug distribution method according to one embodiment of the invention. Specific details for implementing the invention

[0039] Hereinafter, embodiments of the present invention are described in detail with reference to the attached drawings so that those skilled in the art can easily implement the present invention. The present invention may be embodied in various different forms and is not limited to the embodiments described herein. In the drawings, parts unrelated to the explanation have been omitted to clearly explain the present invention, and the same reference numerals have been used for identical or similar components throughout the specification.

[0040] The words and terms used in this specification and claims are not limited to their ordinary or dictionary meanings, but should be interpreted in a meaning and concept consistent with the technical spirit of the invention in accordance with the principles by which the inventor defines terms and concepts to best describe his invention.

[0041] In this specification, terms such as “comprising” or “having” are intended to describe the existence of the features, numbers, steps, actions, components, parts, or combinations thereof described in the specification, and should not be understood as precluding the existence or addition of one or more other features, numbers, steps, actions, components, parts, or combinations thereof.

[0042] Thickness or size has been exaggerated in the drawings to clearly express the characteristics of the configuration, and the thickness or size of the configuration shown in the drawings is not necessarily the same as the actual value.

[0043] Some embodiments of the present disclosure may be represented by functional block configurations and various processing steps. Some or all of these functional blocks may be implemented by various numbers of hardware and / or software configurations that execute specific functions. For example, the functional blocks of the present disclosure may be implemented by one or more microprocessors or by circuit configurations for a specific function. Additionally, for example, the functional blocks of the present disclosure may be implemented in various programming or scripting languages. The functional blocks may be implemented as algorithms executed on one or more processors. Furthermore, the present disclosure may employ prior art for electronic configuration, signal processing, and / or data processing, etc.

[0044] In the following description, descriptions of some components may be omitted to clarify the features of the present invention.

[0045] FIG. 1 is a diagram illustrating a radioactive drug distribution system according to an embodiment of the present invention. FIG. 2 is a diagram illustrating the first syringe and the source container communicating in a radioactive drug distribution system according to an embodiment of the present invention. FIG. 3 is a diagram illustrating the first syringe and the dilution container communicating in a radioactive drug distribution system according to an embodiment of the present invention. FIG. 4 is a diagram illustrating the state in which the mixing of the radioactive drug and the diluent is completed within the first syringe in a radioactive drug distribution system according to an embodiment of the present invention. FIG. 5 is a diagram illustrating the distribution of the mixed solution of the radioactive drug and the diluent from the first syringe to the first distribution container in a radioactive drug distribution system according to an embodiment of the present invention. FIG. 6 is a diagram illustrating the state in which the distribution of the mixed solution of the radioactive drug and the diluent from the first syringe to the first distribution container is completed in a radioactive drug distribution system according to an embodiment of the present invention.

[0046] A radioactive drug distribution system (1) and a radioactive drug distribution method using the same according to one embodiment of the present invention are a radioactive drug distribution system (1) capable of distributing low-dose and high-dose radioactive drugs as a single system and a radioactive drug distribution method using the same.

[0047] A radioactive drug distribution system (1) according to one embodiment of the present invention is a radioactive drug distribution system that distributes a solution in which a radioactive drug stored in a source container (31) and a diluent stored in a dilution container (32) are mixed.

[0048] Referring to FIGS. 1 and 2, a radioactive drug dispensing system (1) according to one embodiment of the present invention may include a first syringe (10) and a second syringe (20) for extracting a radioactive drug from a source container (31) and drawing a diluent from a dilution container (32) to make a mixed solution in which the radioactive drug and the diluent are mixed.

[0049] In addition, a radioactive drug dispensing system (1) according to one embodiment of the present invention may further include a first manifold (50) comprising a plurality of valves that control a flow path connecting a first syringe (10) and a second syringe (20), a source container (31) and a delusion container (32), and a second manifold (60) located downstream of the first manifold (50) and comprising a valve that controls a dispensing flow path through which a mixed solution is dispensed.

[0050] Referring to FIG. 1, a source container (31) of a radioactive drug distribution system (1) according to one embodiment of the present invention may be connected to a source flow path (73). Additionally, a delusion container (32) may be connected to a delusion flow path (74).

[0051] At this time, the source Euro (73) can be connected to a source valve (53) provided in the first manifold (50).

[0052] At this time, the source valve (53) is a valve connected in three directions, and two of the three ends constituting the source valve (53) are each connected to the first manifold path (791) provided within the first manifold (50), and the remaining one end constituting the source valve (53) may be connected to the source path (73) or located in a position not connected to the source path (73).

[0053] At this time, when the source valve (53) is connected to the source flow path (73), the radioactive drug in the source container (31) communicating with the source flow path (73) can flow through the source flow path (73) to the first manifold flow path (791).

[0054] Additionally, if the source valve (53) is located in a position where it is not connected to the source flow path (73), the radioactive drug in the source container (31) may not flow into the first manifold flow path (791) and may be blocked by the source valve (53).

[0055] Likewise, the delusion valve (54) is a valve connected in three directions, and two of the three ends constituting the delusion valve (54) are each connected to the first manifold passage (791) provided within the first manifold (50), and the remaining end constituting the delusion valve (54) may be connected to the delusion passage (74) or located in a position not connected to the delusion passage (74).

[0056] At this time, when the delusion valve (54) is connected to the delusion path (74), the diluted liquid in the delusion container (32) communicating with the delusion path (74) can flow to the first manifold path (791) via the delusion path (74).

[0057] Additionally, if the dilution valve (54) is located in a position not connected to the dilution path (74), the dilution liquid in the dilution container (32) may not flow into the first manifold path (791) and may be blocked by the dilution valve (54).

[0058] Meanwhile, the first syringe (10) can be connected to the first syringe path (71). Additionally, the second syringe (20) can be connected to the second syringe path (72).

[0059] At this time, the first syringe path (71) can be connected to the first syringe valve (51) provided in the first manifold (50).

[0060] At this time, the first syringe valve (51) is a valve connected in three directions, and two of the three ends constituting the first syringe valve (51) are each connected to the first manifold path (791) provided within the first manifold (50), and the remaining one end constituting the first syringe valve (51) may be connected to the first syringe path (71) or positioned in a location not connected to the first syringe path (71).

[0061] At this time, when the first syringe valve (51) is connected to the first syringe path (71), a fluid containing a radioactive drug or a diluent can enter or exit through the first syringe (10) that is in communication with the first syringe path (71).

[0062] Additionally, if the first syringe valve (51) is positioned so as not to be connected to the first syringe path (71), fluid flow between the first syringe (10) and the first manifold path (791) can be blocked by the first syringe valve (51).

[0063] Likewise, the second syringe valve (52) is a valve connected in three directions, wherein two of the three ends constituting the second syringe valve (52) are each connected to the first manifold path (791) provided within the first manifold (50), and the remaining end constituting the second syringe valve (52) may be connected to the second syringe path (72) or positioned in a location not connected to the second syringe path (72).

[0064] At this time, when the second syringe valve (52) is connected to the second syringe path (72), a fluid containing a radioactive drug or a diluent can enter or exit through the second syringe (20) that is in communication with the second syringe path (72).

[0065] Additionally, if the second syringe valve (52) is positioned so as not to be connected to the second syringe path (72), fluid flow between the second syringe (20) and the first manifold path (791) can be blocked by the second syringe valve (52).

[0066] Accordingly, the flow direction of the radioactive drug and the diluent can be controlled according to the connection state of the first syringe valve (51), the second syringe valve (52), the source valve (53), and the dilution valve (54) constituting the first manifold (50).

[0067] Referring to FIG. 1, a radioactive drug dispensing system (1) according to one embodiment of the present invention may include a radioactivity sensor (91) for measuring the amount of radioactivity of a source container (31).

[0068] By measuring the amount of radioactivity of the source container (31) with the radioactivity sensor (91), the amount of radioactivity emitted by the radioactive drug contained in the source container (31) can be determined.

[0069] At this time, when a radioactive drug flows from the source container (31) to the outside of the source container (31) through the source flow path (73), the amount of radioactivity emitted by the source container (31) may be reduced.

[0070] Conversely, if a radioactive drug is introduced into the source container (31) through the source channel (73), the amount of radioactivity emitted by the source container (31) may increase.

[0071] Accordingly, the amount of radioactivity in the source container (31) can be measured in real time using a radioactivity sensor (91), and an accurate amount of radioactive drug can be transported through the flow path.

[0072] As shown in FIG. 2, when the plunger of the first syringe (10) is retracted while the first syringe valve (51) and the source valve (53) are open, radioactive drug can be introduced into the first syringe (10).

[0073] At this time, the amount of radioactivity reduced in the source container (31) can be checked using the radioactivity sensor (91) to transfer an accurate amount of radioactive drug to the first syringe (10).

[0074] At this time, if a larger amount of radioactive drug than the target amount is introduced into the first syringe (10), the plunger of the first syringe (10) can be advanced to allow the radioactive drug introduced into the first syringe (10) to be discharged outside the first syringe (10).

[0075] In this case, the radioactive drug leaked from the first syringe (10) can be recovered into the source container (31). The amount of radioactive drug recovered into the source container (31) can be measured in real time by the radioactivity sensor (91).

[0076] Meanwhile, the first syringe (10) is equipped with a separate distance sensor (92) so that the distance traveled by the plunger of the first syringe (10) can be precisely measured. Accordingly, the amount of radioactive drug introduced into the first syringe (10) can be measured in real time.

[0077] Meanwhile, when a target amount of radioactive drug is introduced into the first syringe (10), the source valve (53) may be closed and the dilation valve (54) may be opened.

[0078] In this case, the first syringe valve (51) and the dilution valve (54) are positioned in an open state so that the dilution solution contained in the dilution container (32) can flow into the first syringe (10) via the dilution path (74) and the first syringe path (71).

[0079] At this time, the plunger of the first syringe (10) can be retracted so that the diluted solution flows into the first syringe (10).

[0080] At this time, a mixed solution can be formed by mixing the radioactive drug previously introduced into the first syringe (10) and the diluent newly introduced into the first syringe (10).

[0081] After the mixed solution is formed in the first syringe (10), the dilation valve (54) can be switched to a closed state as shown in FIG. 4 to distribute the formed mixed solution.

[0082] Accordingly, even if the mixed solution in the first syringe (10) flows out through the first syringe flow path (71), it is possible to prevent the mixed solution from flowing into the delusion container (32).

[0083] Afterwards, some of the multiple distribution valves provided in the second manifold (60) for dispensing the mixed solution can be opened as shown in FIG. 5.

[0084] The second manifold (60) may be located downstream of the first manifold (50). The second manifold (60) may be equipped with a plurality of distribution valves that each control a plurality of distribution paths.

[0085] Referring to FIGS. 1 to 5, as an example, the distribution channel may be composed of six distribution channels, such as a first distribution channel (761), a second distribution channel (762), a third distribution channel (763), a fourth distribution channel (764), a fifth distribution channel (765), and a sixth distribution channel (766).

[0086] This is for illustrative purposes only, and the number of distributed Euros may be increased or decreased depending on the purpose.

[0087] Each distribution euro (761, 762, 763, 764, 765, 766) may have a corresponding distribution container (331, 332, 333, 334, 335, 336) placed therein.

[0088] Meanwhile, the second manifold (60) may be equipped with a distribution valve (61, 62, 63, 64, 65, 66) corresponding to each distribution path (761, 762, 763, 764, 765, 766).

[0089] At this time, the second manifold (60) may be provided as a single unit, and all distribution valves (61, 62, 63, 64, 65, 66) may be provided in a single second manifold (60), and it is not limited to providing multiple second manifolds (60) equipped with multiple distribution valves as in the illustrated embodiment.

[0090] In the case of the illustrated embodiment as an example, two second manifolds (60) may be provided.

[0091] At this time, one of the two second manifolds (60) may be equipped with a first distribution valve (61) that controls a first distribution path (761), a third distribution valve (63) that controls a third distribution path (763), and a fourth distribution valve (64) that controls a fourth distribution path (764).

[0092] Additionally, the remaining second manifold (60) may be equipped with a second distribution valve (62) for controlling the second distribution path (762), a fifth distribution valve (65) for controlling the fifth distribution path (765), and a sixth distribution valve (66) for controlling the sixth distribution path (766).

[0093] At this time, each second manifold (60) can be connected to the first manifold (50) through a connecting channel (78).

[0094] As described, when a radioactive drug distribution system (1) according to one embodiment of the present invention has two second manifolds (60), two connecting channels (78) may be provided.

[0095] At this time, one end of each connecting path (78) can be connected to the first manifold (50), and the other end of each connecting path (78) can be connected to the second manifold (60).

[0096] In the case of a radioactive drug distribution system (1) formed with such a structure, as shown in FIG. 5, the mixed solution in the first syringe (10) can be discharged into the first distribution container (331) when the first syringe valve (51) and the first distribution valve (61) are open.

[0097] This is exemplary, and when the second distribution valve (62) is opened instead of the first distribution valve (61), the mixed solution in the first syringe (10) can be discharged into the second distribution container (332).

[0098] Likewise, if the third distribution valve (63) is opened instead of the first distribution valve (61), the mixed solution in the first syringe (10) can be discharged into the third distribution container (333).

[0099] At this time, the user can adjust the amount of radioactivity of the distributed solution by alternately opening the first syringe valve (51) and the dilation valve (54) according to the purpose of use.

[0100] For example, if the radioactivity concentration of the mixed solution contained in the first syringe valve (51) has a value of 1 per unit volume, in order to distribute the radioactive drug mixed solution with a radioactivity of 1 to the first distribution container (331), a unit volume of the mixed solution can be discharged from the first syringe valve (51) toward the first distribution container (331).

[0101] Afterward, the first syringe valve (51) is closed and the dilution valve (54) is open, allowing the diluted liquid to flow out toward the first distribution container (331).

[0102] In contrast, when the radioactivity concentration of the mixed solution contained in the first syringe valve (51) has a value of 1 per unit volume, in order to distribute a radioactive drug mixed solution with a radioactivity of 3 to the first distribution container (331), three times the unit volume of the mixed solution can be discharged from the first syringe valve (51) toward the first distribution container (331).

[0103] Afterward, the first syringe valve (51) is closed and the dilution valve (54) is open, allowing the diluted liquid to flow out toward the first distribution container (331).

[0104] Accordingly, a radioactive drug mixture solution having various amounts of radioactivity can be distributed using the mixture solution contained in the first syringe (10).

[0105] At this time, the first distribution container (331) is equipped with a separate radiation level sensor (91), so that the radiation level of the radioactive drug mixture solution distributed to the first distribution container (331) can be measured in real time.

[0106] Accordingly, the user can check the amount of radioactivity in real time through the radioactivity sensor (91) and repeatedly dispense a radioactive drug mixture solution that is less than the prescribed amount into the first distribution container (331).

[0107] Accordingly, it is possible to prevent an excessive amount of radioactive drug mixture solution from being distributed to the first distribution container (331).

[0108] Afterward, as shown in FIG. 6, once the distribution of the radioactive drug mixture solution is completed, the first distribution valve (61) can be closed to prevent further distribution to the first distribution container (331).

[0109] FIG. 7 is a diagram illustrating the filling of a diluent into a first syringe for the recovery of a mixed solution within a radioactive drug distribution system according to an embodiment of the present invention. FIG. 8 is a diagram illustrating the recovery of a mixed solution to a drainage container using a first syringe and a first pump of a radioactive drug distribution system according to an embodiment of the present invention. FIG. 9 is a diagram illustrating the recovery of a mixed solution to a drainage container using a first pump of a radioactive drug distribution system according to an embodiment of the present invention.

[0110] Referring to FIGS. 7 to 9, after the distribution of the mixed solution discharged from the first syringe (10) is completed, a washing operation may be performed to remove the radioactive drug remaining in the first manifold (50), the second manifold (60), and the first syringe (10).

[0111] To this end, as shown in FIG. 7, the first syringe valve (51) and the dilation valve (54) can be opened.

[0112] Accordingly, the diluted solution contained in the dilution container (32) can flow toward the first syringe (10).

[0113] Afterwards, as shown in FIG. 8, the plunger of the first syringe (10) can advance to discharge the diluted solution contained in the first syringe (10).

[0114] At this time, the diluted solution can be discharged to the outside through the first manifold (50) and the second manifold (60) via the drainage channel (77) located downstream of the second manifold (60).

[0115] At this time, the diluted liquid discharged through the drainage channel (77) can be contained in a separate drainage container (34).

[0116] In this process, the diluent passes through each flow path of the radioactive drug distribution system (1) according to one embodiment of the present invention, and can wash away the radioactive drug remaining in each flow path.

[0117] Meanwhile, referring to FIG. 9, a radioactive drug distribution system (1) according to one embodiment of the present invention may further include a first pump (82) that applies pressure to one side to form positive pressure within the flow path.

[0118] At this time, the first pump (82) can be connected to the first manifold (50) through the positive pressure path (75).

[0119] Referring to FIG. 1, the first manifold (50) may further include a positive pressure valve (55) that controls the fluid flow of the positive pressure path (75).

[0120] The first pump (82) can be connected to the first positive pressure path (751) connected to the end of the positive pressure path (75).

[0121] At this time, the first pump (82) can form positive pressure by receiving gas and pushing it to one side. The gas supplied to the first pump (82) may be, for example, argon gas.

[0122] When the first pump (82) forms positive pressure and the positive pressure valve (55) is opened, positive pressure is formed in the first manifold (50), and a flow of gas from upstream to downstream may occur.

[0123] The gas pushed out by the first pump (82) can be discharged to the outside of the flow path, thereby washing away foreign substances or radioactive drugs remaining in the flow path.

[0124] Meanwhile, a radioactive drug distribution system (1) according to one embodiment of the present invention may further include a second pump (84) that forms a positive pressure of higher pressure than the first pump (82).

[0125] At this time, the second pump (84) can be connected to the second positive pressure path (752) branched from the positive pressure path (75) and the first positive pressure path (751).

[0126] For example, the first positive pressure channel (751) and the second positive pressure channel (752) may be formed to join at the positive pressure channel (75).

[0127] The second pump (84) can form positive pressure by receiving gas and pushing it to one side. The gas supplied to the second pump (84) may be, for example, argon gas.

[0128] Accordingly, if the radioactive drug distribution system (1) according to one embodiment of the present invention is not cleaned smoothly by the positive pressure of the first pump (82) alone, it is possible to clean the radioactive drug distribution system (1) smoothly by using additional positive pressure using the second pump (84).

[0129] At this time, in order to check the cleaning status of the flow path of the radioactive drug distribution system (1) according to one embodiment of the present invention, a radioactivity sensor (91) may be provided in a section of the flow path of the radioactive drug distribution system (1) according to one embodiment of the present invention.

[0130] For example, referring to FIG. 1, a radiation level sensor (91) can be placed near the drainage channel (77).

[0131] FIG. 10 is a diagram illustrating the second syringe and the source container communicating in a radioactive drug distribution system according to an embodiment of the present invention. FIG. 11 is a diagram illustrating the second syringe and the dilution container communicating in a radioactive drug distribution system according to an embodiment of the present invention. FIG. 12 is a diagram illustrating the state in which the mixing of the radioactive drug and the diluent is completed within the second syringe in a radioactive drug distribution system according to an embodiment of the present invention. FIG. 13 is a diagram illustrating the distribution of the mixed solution of the radioactive drug and the diluent from the second syringe to the second distribution container in a radioactive drug distribution system according to an embodiment of the present invention. FIG. 14 is a diagram illustrating the completion of the distribution of the mixed solution of the radioactive drug and the diluent from the second syringe to the second distribution container in a radioactive drug distribution system according to an embodiment of the present invention.

[0132] As shown in FIG. 10, when the plunger of the second syringe (20) is retracted while the second syringe valve (52) and the source valve (53) are open, radioactive drug can be introduced into the second syringe (20).

[0133] At this time, the amount of radioactivity reduced in the source container (31) can be checked using the radioactivity sensor (91) to transfer an accurate amount of radioactive drug to the second syringe (20).

[0134] At this time, if a larger amount of radioactive drug than the target amount is introduced into the second syringe (20), the plunger of the second syringe (20) can be advanced to allow the radioactive drug introduced into the second syringe (20) to be discharged outside the second syringe (20).

[0135] In this case, the radioactive drug leaked from the second syringe (20) can be recovered into the source container (31). The amount of radioactive drug recovered into the source container (31) can be measured in real time by the radioactivity sensor (91).

[0136] Meanwhile, the second syringe (20) is equipped with a separate distance sensor (92) so that the distance traveled by the plunger of the second syringe (20) can be precisely measured. Accordingly, the amount of radioactive drug introduced into the second syringe (20) can be measured in real time.

[0137] Meanwhile, when a target amount of radioactive drug is introduced into the second syringe (20), the source valve (53) may be closed and the dilation valve (54) may be opened.

[0138] In this case, the second syringe valve (52) and the dilution valve (54) are positioned in an open state so that the dilution solution contained in the dilution container (32) can flow into the second syringe (20) via the dilution path (74) and the second syringe path (72).

[0139] At this time, the plunger of the second syringe (20) can be retracted so that the diluted solution flows into the second syringe (20).

[0140] At this time, the radioactive drug previously introduced into the second syringe (20) and the diluent newly introduced into the second syringe (20) can be mixed to form a mixed solution.

[0141] After the mixed solution is formed in the second syringe (20), the dilation valve (54) can be switched to a closed state as shown in FIG. 12 to distribute the formed mixed solution.

[0142] Accordingly, even if the mixed solution in the second syringe (20) flows out through the second syringe flow path (72), it is possible to prevent the mixed solution from flowing into the delusion container (32).

[0143] Afterwards, some of the multiple distribution valves provided in the second manifold (60) for dispensing the mixed solution can be opened as shown in FIG. 13.

[0144] Accordingly, with the second syringe valve (52) and the second distribution valve (62) open, the mixed solution in the second syringe (20) can be discharged into the second distribution container (332).

[0145] This is exemplary, and when the first distribution valve (61) is opened instead of the second distribution valve (62), the mixed solution in the second syringe (20) can be discharged into the second distribution container (332).

[0146] Likewise, if the third distribution valve (63) is opened instead of the second distribution valve (62), the mixed solution in the second syringe (20) can be discharged into the third distribution container (333).

[0147] At this time, the user can adjust the amount of radioactivity of the distributed solution by alternately opening the second syringe valve (52) and the dilation valve (54) according to the purpose of use.

[0148] For example, if the concentration of radioactivity of the mixed solution contained in the second syringe valve (52) has a value of 50 per unit volume, in order to distribute the radioactive drug mixed solution with a radioactivity of 50 to the second distribution container (332), a unit volume of the mixed solution can be discharged from the second syringe valve (52) toward the second distribution container (332).

[0149] Afterward, the second syringe valve (52) is closed and the dilution valve (54) is open, allowing the diluted liquid to flow out toward the second distribution container (332).

[0150] In contrast, when the radioactivity concentration of the mixed solution contained in the second syringe valve (52) has a value of 50 per unit volume, in order to distribute a radioactive drug mixed solution with a radioactivity of 200 to the second distribution container (332), four times the unit volume of the mixed solution can be discharged from the second syringe valve (52) toward the second distribution container (332).

[0151] Afterward, the second syringe valve (52) is closed and the dilution valve (54) is open, allowing the diluted liquid to flow out toward the second distribution container (332).

[0152] Accordingly, a radioactive drug mixture solution having various amounts of radioactivity can be distributed using the mixed solution contained in the second syringe (20).

[0153] At this time, the second distribution container (332) is equipped with a separate radiation level sensor (91), so that the radiation level of the radioactive drug mixture solution distributed to the second distribution container (332) can be measured in real time.

[0154] Accordingly, the user can check the amount of radioactivity in real time through the radioactivity sensor (91) and repeatedly dispense a radioactive drug mixture solution that is less than the prescribed amount into the second distribution container (332).

[0155] Accordingly, it is possible to prevent an excessive amount of radioactive drug mixture solution from being distributed to the second distribution container (332).

[0156] Afterward, as shown in FIG. 14, once the distribution of the radioactive drug mixture solution is completed, the second distribution valve (62) can be closed to prevent further distribution to the second distribution container (332).

[0157] FIG. 15 is a diagram illustrating the filling of a diluent into a second syringe for the recovery of a mixed solution within a radioactive drug distribution system according to an embodiment of the present invention. FIG. 16 is a diagram illustrating the recovery of a mixed solution to a drainage container using a second syringe and a first pump of a radioactive drug distribution system according to an embodiment of the present invention. FIG. 17 is a diagram illustrating the recovery of a mixed solution to a drainage container using a first pump of a radioactive drug distribution system according to an embodiment of the present invention. FIG. 18 is a diagram illustrating the recovery of a mixed solution to a drainage container using a first pump of a radioactive drug distribution system according to an embodiment of the present invention.

[0158] Referring to FIGS. 15 to 17, after the distribution of the mixed solution discharged from the second syringe (20) is completed, a washing operation may be performed to remove the radioactive drug remaining in the first manifold (50), the second manifold (60), and the second syringe (20).

[0159] To this end, as shown in FIG. 15, the second syringe valve (52) and the dilation valve (54) can be opened.

[0160] Accordingly, the diluted solution contained in the dilution container (32) can flow toward the second syringe (20).

[0161] Afterwards, as shown in FIG. 16, the plunger of the second syringe (20) can advance to discharge the diluted solution contained in the second syringe (20).

[0162] At this time, the diluted solution can be discharged to the outside through the first manifold (50) and the second manifold (60) via the drainage channel (77) located downstream of the second manifold (60).

[0163] At this time, the diluted liquid discharged through the drainage channel (77) can be contained in a separate drainage container (34).

[0164] In this process, the diluent passes through each flow path of the radioactive drug distribution system (1) according to one embodiment of the present invention, and can wash away the radioactive drug remaining in each flow path.

[0165] Meanwhile, referring to FIG. 17, a radioactive drug distribution system (1) according to one embodiment of the present invention may further include a first pump (82) that applies pressure to one side to form positive pressure within the flow path.

[0166] At this time, the first pump (82) can be connected to the first manifold (50) through the positive pressure path (75).

[0167] Referring to FIG. 1, the first manifold (50) may further include a positive pressure valve (55) that controls the fluid flow of the positive pressure path (75).

[0168] The first pump (82) can be connected to the first positive pressure path (751) connected to the end of the positive pressure path (75).

[0169] At this time, the first pump (82) can form positive pressure by receiving gas and pushing it to one side. The gas supplied to the first pump (82) may be, for example, argon gas.

[0170] When the first pump (82) forms positive pressure and the positive pressure valve (55) is opened, positive pressure is formed in the first manifold (50), and a flow of gas from upstream to downstream may occur.

[0171] The gas pushed out by the first pump (82) can be discharged to the outside of the flow path, thereby washing away foreign substances or radioactive drugs remaining in the flow path.

[0172] Meanwhile, a radioactive drug distribution system (1) according to one embodiment of the present invention may further include a second pump (84) that forms a positive pressure of higher pressure than the first pump (82).

[0173] At this time, the second pump (84) can be connected to the second positive pressure path (752) branched from the positive pressure path (75) and the first positive pressure path (751).

[0174] For example, the first positive pressure channel (751) and the second positive pressure channel (752) may be formed to join at the positive pressure channel (75).

[0175] The second pump (84) can form positive pressure by receiving gas and pushing it to one side. The gas supplied to the second pump (84) may be, for example, argon gas.

[0176] Accordingly, if the radioactive drug distribution system (1) according to one embodiment of the present invention is not cleaned smoothly by the positive pressure of the first pump (82) alone, it is possible to clean the radioactive drug distribution system (1) smoothly by using additional positive pressure using the second pump (84).

[0177] At this time, in order to check the cleaning status of the flow path of the radioactive drug distribution system (1) according to one embodiment of the present invention, a radioactivity sensor (91) may be provided in a section of the flow path of the radioactive drug distribution system (1) according to one embodiment of the present invention.

[0178] For example, referring to FIG. 1, a radiation level sensor (91) can be placed near the drainage channel (77).

[0179] A radioactive drug dispensing system (1) according to one embodiment of the present invention, formed with such a structure, can form a mixed solution that emits different amounts of radioactivity to a first syringe (10) and a second syringe (20).

[0180] Using this, it is possible to dispense radioactive drug mixture solutions with varying radioactivity levels, such as diagnostic I-131 mIBG drugs and therapeutic I-131 mIBG drugs, into a single system.

[0181] For example, in the case of a diagnostic I-131 mIBG drug with a dosage range of 1 mCi to 3 mCi, a mixed solution formed by mixing a small amount of I-131 mIBG drug and a diluent can be obtained by dispensing it into a first syringe (10).

[0182] On the other hand, for therapeutic I-131 mIBG drugs in the dosage range of 30 mCi to 200 mCi, a mixed solution formed by mixing a relatively large amount of I-131 mIBG drug and a diluent in a second syringe (20) can be obtained.

[0183] In addition, although not illustrated, it is not limited to dispensing a radioactive drug mixture solution by using the first syringe (10) and the second syringe (20) simultaneously to cross-dispense the mixture solution in the first syringe (10) and the mixture solution in the second syringe (20).

[0184] Meanwhile, referring to FIG. 1, a radioactive drug dispensing system (1) according to one embodiment of the present invention may further include a needle holder (42) equipped with a needle for dispensing a mixed solution into a plurality of dispensing containers (331, 332, 333, 334, 335, 336).

[0185] At this time, the needle mounted on the needle holder (42) can be connected to the end of each distribution channel (761, 762, 763, 764, 765, 766).

[0186] The needle holder (42) may be equipped with an actuator (44) that moves the needle holder (42) in an up-and-down direction and a guide (46) that guides the needle holder (42) to move in an up-and-down direction.

[0187] Accordingly, when the actuator (44) moves the needle holder (42) upward, the needle mounted on the needle holder (42) can be separated from each distribution container (331, 332, 333, 334, 335, 336).

[0188] Conversely, when the actuator (44) moves the needle holder (42) downward, the needle mounted on the needle holder (42) can be inserted into each distribution container (331, 332, 333, 334, 335, 336).

[0189] Accordingly, while the dispensing of the radioactive drug mixture solution is being performed, the actuator (44) can position the needle holder (42) at a predetermined height so that the needle mounted on the needle holder (42) remains inserted in the dispensing container (331, 332, 333, 334, 335, 336). Additionally, after the dispensing of the radioactive drug mixture solution is completed, the actuator (44) can raise the needle holder (42) to separate the needle from the dispensing container (331, 332, 333, 334, 335, 336).

[0190] Hereinafter, a method for dispensing a radioactive drug using a radioactive drug dispensing system (1) according to one embodiment of the present invention will be described.

[0191] FIG. 19 is a flowchart illustrating a radioactive drug dispensing method according to one embodiment of the invention. FIG. 20 is a flowchart illustrating in detail the step of determining the dispensing amount of a radioactive drug dispensing method according to one embodiment of the invention.

[0192] Referring to FIG. 19, a radioactive drug dispensing method according to one embodiment of the present invention may include a dispensing amount determination step (S100) for determining the required amount of radioactive drug, a drug extraction step (S200) for extracting the radioactive drug and storing it in a first syringe (10) or a second syringe (20), a drug dilution step (S300) for mixing the radioactive drug with a diluent, and a drug dispensing step (S400) for dispensing the solution in which the radioactive drug and the diluent are mixed.

[0193] At this time, referring to FIG. 20, the distribution amount determination step (S100) may include a target amount verification step (S110), a dilution amount calculation step (S120), and a syringe selection step (S130).

[0194] More specifically, the distribution amount determination step (S100) includes a step (S110) of confirming the target radioactivity level of the radioactive drug mixture solution according to the purpose of use of the radioactive drug to be used.

[0195] For example, a diagnostic agent using I-131 mIBG used for the diagnosis and treatment of neuroendocrine tumors can have a target radiation dose of 1 mCi to 3 mCi. In addition, a therapeutic agent using I-131 mIBG can have a target radiation dose of 30 mCi to 200 mCi.

[0196] After the target radiation dose is confirmed in this way, a dilution amount calculation step (S120) can be performed to calculate the amount of radioactive drug required for mixing the radioactive drug mixture solution and the amount of the diluent.

[0197] Afterward, after the dilution amount calculation is performed, a syringe selection step (S130) may be performed to select which syringe, the first syringe (10) or the second syringe (20), will be used to form the mixed solution according to the range of the target radiation dose.

[0198] For example, in the case of a diagnostic agent using I-131 mIBG, a first syringe (10) may be selected, and in the case of a therapeutic agent using I-131 mIBG, a second syringe (20) may be selected.

[0199] Subsequently, in the drug extraction step (S200), the radioactive drug contained in the source container (31) can be extracted to the first syringe (10) or the second syringe (20) using the previously selected first syringe (10) or second syringe (20).

[0200] At this time, as described above, the first syringe valve (51) or the second syringe valve (52) and the source valve (53) can be opened.

[0201] Subsequently, in the drug dilution step (S300), the diluted solution contained in the dilution container (32) can be extracted to the first syringe (10) or the second syringe (20) using the previously selected first syringe (10) or second syringe (20).

[0202] At this time, as described above, the first syringe valve (51) or the second syringe valve (52) and the dilation valve (54) can be opened.

[0203] Afterwards, in the drug dispensing step (S400), the mixed solution formed in the first syringe valve (51) or the second syringe valve (52) can be dispensed to the dispensing container.

[0204] Although an embodiment of the present invention has been described above, the concept of the present invention is not limited to the embodiments presented in this specification. Those skilled in the art who understand the concept of the present invention may easily propose other embodiments within the scope of the same concept by adding, changing, deleting, or adding components, and such embodiments shall also be considered to fall within the scope of the concept of the present invention. Explanation of the symbols

[0206] 1 Radioactive drug distribution system 10 First syringe 20 2nd syringe 31 Source Container 32 Delusion Containers 33 Distribution Container 331 1st Distribution Container 332 Second Distribution Container 333 Third Distribution Container 334 4th Distribution Container 335 5th Distribution Container 336 6th Distribution Container 34 drainage containers 40 Needle Movement Module 42 Needle Holder 44 Actuator 46 Guide 50 1st Manifold 51 First syringe valve 52 Second syringe valve 53 Source Valve 54 Delusion Valve 55 Positive pressure valve 60 2nd Manifold 61 First distribution valve 62 Second distribution valve 63 Third distribution valve 64 4th distribution valve 65 5th distribution valve 66 6th distribution valve 71 1st syringe Euro 72 2nd syringe Euro 73 Source Euro 74 Delusion Euro 751 1st Positive Pressure Flow Path 752 Second positive pressure flow path 761 First Distribution Euro 762 Second Distribution Euro 763 Third Distribution Euro 764 4th Distribution Euro 765 5th Distribution Euro 766 Sixth Distribution Euro 77 multiple Euro 78 connection Euro 791 1st Manifold Euro 792 2nd Manifold Euro 82 First Pump 84 Second Pump 91 Radiation level sensor 92 distance sensor

Claims

Claim 1 A radioactive drug distribution system for dispensing a solution in which a radioactive drug stored in a source container and a diluent stored in a delusion container are mixed, comprising: a first syringe; a second syringe; a first manifold comprising a source valve for controlling the fluid flow of a source channel communicating with the source container, a delusion valve for controlling the fluid flow of a delusion channel communicating with the delusion container, a first syringe valve for controlling the fluid flow of a first syringe channel communicating with the first syringe, and a second syringe valve for controlling the fluid flow of a second syringe channel communicating with the second syringe; and a second manifold located downstream of the first manifold, comprising a first distribution valve communicating with a first distribution channel for dispensing the solution to a first distribution container. Claim 2 A radioactive drug dispensing system according to claim 1, wherein the first manifold further comprises a second first manifold flow path fluidically connecting the source valve, the delusion valve, the first syringe valve, and the second syringe valve, wherein the source valve controls the connection state between the first manifold flow path and the source flow path while in communication with the first manifold flow path, the delusion valve controls the connection state between the first manifold flow path and the delusion flow path while in communication with the first manifold flow path, the first syringe valve controls the connection state between the first syringe flow path and the source flow path while in communication with the first manifold flow path, and the second syringe valve controls the connection state between the second syringe flow path and the source flow path while in communication with the first manifold flow path. Claim 3 A radioactive drug dispensing system according to claim 1, wherein when the first syringe valve opens the first syringe flow path and the source valve opens the source flow path, the first syringe draws the radioactive drug stored in the source container toward the first syringe. Claim 4 A radioactive drug dispensing system according to claim 1, wherein when the first syringe valve opens the first syringe flow path and the dilution valve opens the dilution flow path, the first syringe draws the diluent stored in the dilution container toward the first syringe side and the radioactive drug and the diluent are mixed within the first syringe. Claim 5 A radioactive drug dispensing system according to claim 1, wherein when the second syringe valve opens the second syringe flow path and the source valve opens the source flow path, the second syringe draws the radioactive drug stored in the source container toward the second syringe. Claim 6 A radioactive drug dispensing system according to claim 1, wherein when the second syringe valve opens the first syringe flow path and the dilution valve opens the dilution flow path, the second syringe draws the diluent stored in the dilution container toward the second syringe side and the radioactive drug and the diluent are mixed within the second syringe. Claim 7 A radioactive drug dispensing system according to claim 1, wherein the radioactive drug and the diluent are mixed in the first syringe and the second syringe, and the radioactive drug and the diluent are mixed at different concentrations in the first syringe and the second syringe. Claim 8 A radioactive drug distribution system according to claim 1, wherein the second manifold further comprises a second distribution valve communicating with a second distribution channel for distributing the solution to a second distribution container. Claim 9 A radioactive drug distribution system according to claim 8, wherein the second manifold further comprises a plurality of distribution valves communicating with a plurality of distribution channels that distribute the solution to a plurality of distribution containers, respectively. Claim 10 A radioactive drug distribution system according to claim 8, wherein the second manifold is provided in plurality, and each of the second manifolds is independently connected to the first manifold. Claim 11 A radioactive drug distribution system according to claim 1, wherein a drainage channel is provided downstream of the second manifold for draining a solution that is not distributed but passes through the first manifold and the second manifold. Claim 12 A radioactive drug distribution system according to claim 1, further comprising a first pump that applies pressure to one side; wherein the first manifold further comprises a positive pressure valve that controls the fluid flow of a first positive pressure path communicating with the first pump. Claim 13 A radioactive drug distribution system according to claim 12, further comprising a second pump that communicates with a second positive pressure channel branched from the first positive pressure channel and applies a higher pressure than the first pump to one side. Claim 14 A radioactive drug dispensing system according to claim 1, further comprising a radioactivity sensor capable of measuring the amount of radioactivity detected from a radioactive drug stored in the source container. Claim 15 A radioactive drug dispensing system according to claim 1, further comprising a radioactivity sensor capable of confirming whether radioactive drug remains in the drainage channel. Claim 16 A radioactive drug dispensing system according to claim 1, further comprising a distance sensor capable of measuring a change in distance of one end of the first syringe. Claim 17 A method for dispensing a radioactive drug using a radioactive drug dispensing system according to any one of claims 1 to 16, comprising: a dispensing amount determination step for determining a required amount of radioactive drug; a drug extraction step for extracting the radioactive drug and storing it in the first syringe or the second syringe; a drug dilution step for mixing the radioactive drug with the diluent; and a drug dispensing step for dispensing a solution in which the radioactive drug and the diluent are mixed. Claim 18 A method for dispensing a radioactive drug according to claim 17, wherein the dispensing amount determination step comprises: a target amount verification step for verifying the required amount of radioactive drug according to the purpose of use; a dilution amount calculation step for calculating the dilution amount according to the required amount of radioactive drug; and a syringe selection step for selecting a first syringe or a second syringe according to the required amount of radioactive drug.

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