Radiopharmaceuticals targeting the somatostatin receptor 2 and their uses

Abstract

This document provides peptides and conjugates (e.g., radiopharmaceutical conjugates) that have avidity for a somatostatin receptor and their uses. The conjugate may comprise a 6-residue peptide, such as a 6-residue monocyclic peptide, a metal chelating agent, and optionally, a linker connecting the peptide to the chelating agent. The radiopharmaceutical conjugate may further comprise a radionuclide attached to the metal chelating agent.This document also provides methods for preparing the conjugates and methods for treating cancer by administering the described conjugates to a subject in need. The radiopharmaceutical conjugate may further comprise a radionuclide bound to the metal chelating agent. This document also provides methods for preparing the conjugates and methods for treating cancer by administering the described conjugates to a subject in need.