Mitotic cell phase enrichment and ionizing radiation

Abstract

A B S T R A C T The invention relates to a combination therapy comprising administering a mitotic- phase (M-phase) cell cycle arresting compound and a modulator of an interphase cell cycle checkpoint to a subject and delivering ionizing radiation to the same subject for the treatment of a tumor. Provided is for (M-phase) cell cycle arresting compounds, modulators of an interphase cell cycle checkpoint and ionizing radiation for use in such treatments, as well as methods of the treatment involving the use of (M-phase) cell cycle arresting compounds and modulators of an interphase cell cycle checkpoint and ionizing radiation.