A pharmaceutical composition comprising a mutein of human interieukin-2

Abstract

The present invention relates to a pharmaceutical composition comprising a mutein of human interleukin-2 (hIL-2 mutein) or of a fragment thereof, which is numbered correspondingly to the hIL-2 wild type and has an amino acid substitution in at least one of the positions 20, 88 or 126, to be used for the preparation of an agent for the treatment and / or prophylaxis of an autoimmune disease an agent for the treatment and / or prophylaxis of an autoimmune disease, wherein through the substitution at position 88 an asparagine is exchanged for an arginine (hIL-2-N88R), or for a glycine (hIL-2-N88G), or for an isoleucine (hIL-2-N88I), wherein through the substitution at position 20 an aspartic acid is exchanged for a histidine (hIL-2-D20H), or for an isoleucine (hIL-2-D20I), or for a tyrosine (hIL-2-D20Y), wherein through the substitution at position 126, a glutamine is exchanged for a leucine (hIL-2-Q126L).