Anticancer derivatives, preparation thereof and therapeutic use thereof

Abstract

The invention relates to a compound of formula (I): in which: represents a single bond or a double bond  U and / or U', which may be identical or different, represent, independently of each other, H:  W and / or W', which may be identical or different, represent, independently of each other: H, OH, -OR, -OCOR, -COOR, -OCOOR, OCONRR', a cyclic carbamate such that N10 and C11 are included in a ring, -NRCONRR', OCSNHR, a cyclic thiocarbamate such that N10 and C11 are included in a ring, -SH, -SR, SOR, -SOOR, SO3, -NRSOOR', -NRR', a cyclic amine such that N10 and C11 are included in a ring, -NROR', -NRCOR', -N3, -CN, Hal, a trialkylphosphonium or triarylphosphonium group;  R1, R2, R1', R2', which may be identical or different, represent, independently of each other: H, Hal or an optionally substituted group (C1-C6)alkyl; or alternatively R1 and R2 and / or R1' and R2' together form, respectively, a double bond =CH2 or =CHCH3;  Y and Y', which may be identical or different, represent, independently of each other, H or -OR;  M represents CH or N;  ALK and ALK' denote a group (C1-C6)alkylene;  R and R' represent, independently of each other, H or an optionally substituted group (C1-C6)alkyl or aryl;  L1 and L2 represent linkers;  Q represents a single bond or the group C(=O);  G represents a group -OR or -NRR';  RCG1 represents the group -SZa or -C(=O)ZbRb;  Za represents Ac, Ra or SRa;  Ra represents H, or an optionally substituted group (C1-C6)alkyl, (C3-C8)cycloalkyl, aryl, heteroaryl or (C4-C10)heterocycloalkyl;  Zb represents a single bond, -O- or -NH- and Rb representing H or a group (C1-C6)alkyl, (C3C8)cycloalkyl, aryl, heteroaryl or (C4C10)heterocycloalkyl or alternatively Zb represents a single bond and Rb represents Hal; with the condition that if L1 represents a single bond, then RCG1 represents —SZa.