Method of obtaining a transdermal sleeping patch

Abstract

The subject of the application is a method for obtaining a transdermal melatonin-saturated sleep patch, consisting in applying a layer of melatonin with a layer thickness of 5 to 50 micrometers to the patch matrix, wherein a solution of melatonin in ethyl alcohol at a solution concentration of 0.1 to 8.0 mg / ml or a solution of melatonin in water at a solution concentration of 0.1 to 1.0 mg / ml is applied to the patch matrix using an ultrasonic application device with a precision nozzle, equipped with technology ensuring the stability and uniformity of the sprayed solution application process, wherein the parameters of this process are as follows: the frequency of the ultrasonic spray head is used in the range of 100 to 150 kHz, the ultrasound power is used in the range of 0.1 to 20 W, the application process is carried out at a flow rate of the melatonin solution through the nozzle of 0.05 to 0.6 cm3 / min,During application, the ultrasonic head is positioned at a distance of 30 to 50 mm from the matrix surface, then the transdermal patch with the applied melatonin layer is dried in a controlled atmosphere at humidity <10% and temperature from 10°C to 50°C for at least 5 minutes.,