Multipolar magnetic pulse therapy for autism and other neurological disorders

Abstract

This invention discloses a system, method, and device that provides magnetic transcranial stimulation to establish new or adjust existing neuron activities in targeted zones within the brain. This invention corrects neurological pathways that have been damaged, or have dysfunctional neurological systems such as autism, delayed development, and brain trauma, etc. The therapies available using this invention This improved therapy consists primarily of transcranial stimulation (TCS) with precisely targeted magnetic waves rapidly rotating to establish the desired paths of activation. The devices and methods disclosed herein rapidly and painlessly deliver magnetic pulses through the skull to electrically stimulate nerve cells in one or more targeted regions in the brain. The induced electrical activities cause the brain to respond and activate selected cellular pathways in regions of the brain.

Description

MULTIPOLAR MAGNETIC PULSE THERAPY FOR AUTISM AND OTHER NEUROLOGICAL DISORDERS CROSS-REFERENCE TO RELATED APPLICATIONS

[0001] This applica on claims priority to provisional applica ons 63455971 and 63455972 filed March 30, 2023 and 63463542filed May 2, 2023, the contents of which are each incorporated herein in their en re es. INTRODUCTION

[0002] This inven on discloses a system, method, and device which allows for variable magne cflux switching to establish new interneuronal connec ons or to adjust exis ng neuronal ac vi es. The device enables precise targe ng of selected zones within the brain. An exemplary method employing devices of this inven on restores, corrects, replaces, reconfigures, revitalizes, and / or s mulates one or more neurological pathways that have been de-emphasized, damaged, hyperac vated, or present dysfunc onal neurological systems such as au sm, delayed development, and brain trauma, etc. The therapy disclosed herein leads to expected, normal, reinvigorated, or enhanced brain func on(s). The current inven on provides significant improvements over current devices and therapies.

[0003] This improved therapy consists primarily of transcranial s mula on (TCS) with precisely targeted magne c waves rapidly rota ng to establish the desired paths of ac va on. The device features one or more sets of paired electromagnet circuits which rapidly and painlessly deliver magne c pulses through the skull thereby electrically s mula ng nerve or suppor ve cells in one or more targeted regions in the brain. One set or mul ple sets of paired electromagnet circuits may be disposed on or around the scalp under direc on manually or automa cally in accordance with real- me algorithmic messaging or as predetermined based on the subject’s criteria. The pulsing magne cfluxes reorient or drive electrons in thefield to electrically s mulate nerve cells in one or more of targeted regions in the brain. The induced electrical ac vi es cause the brain to respond and ac vate or deac vate selected cellular pathways in regions of the brain that may have become distressed because of, or resul ng from, decreased or abnormal ac vity.

[0004] S mula ng glia, non-neuronal cells, can reconfigure neuronal connec ons and responses and can normalize neuronal responses in the targeted region(s) selected. Different glial cell types characteris cally maximally respond to different s muli (frequency, dura on, flux strength, etc) than the neuronal cells or other glial cell types as they alter their ac vi es to reconfigure neuronal (synap c) connec ons to normalize the neuronal synapse responses inthe targeted region(s). Targeted repe ve magne c s mula on produces electrical ac vity in the targeted cells to alter or induce intercellular signaling. The electrical pulse ac va on at synapses s mulates metabolism, such as ionflux and transport which draws healthful aDen ons, e.g., bloodflow, cell divisions, etc., in the affected region. This induced ion movement and other responses to the targeted s mulus provokes correc ve reorganiza on of neuronal connec ons within the targeted region. The present inven on features therapies for mi ga ng inapt brain ac vi es. The therapies are mul -component including a collec on of monitoring brain func ons(and op onally addi onal organ ac vi es as indicators of brain signaling), and non-invasive cerebral (or cerebellar) s mula on. BACKGROUND OF THE INVENTION

[0005] Current therapies that employ TCS have been shown to be effec ve over a variety of syndromes, condi ons, diseases, etc.; using various applica on protocols, devices, frequencies, frequency of sessions and number of repe ons,field strengths, etc. See, e.g., Wieczorek et al 1021 [doi.org / 10.12740 / PP / OnlineFirst / 115556]. O’Connell et al, 20181, provided the art with a detailed review studying Repe ve Transcranial Magne c S mula on (rTMS) for pain reduc on (258 pp.). However, the current inven on significantly improves pa ent outcomes through the use offinely targeted rapid switching (on-off) of opposing magne c poles s mula ng the development of desired healthy pathways.

[0006] Magne c s mula on that is focused or targeted to induce electric currents and cause cells to respond comprise the physical influences that drive the beneficial outcomes from prac cing this inven on. The delivery of various TCS protocols as thefield has developed varied therapies which have produced varied results. The early crude experiments have led to improved and improving devices for genera ng the electric current inducing magne cfields that have been applied around and to varied areas of the human skull. While the art has benefited from over a century of experiments and varying therapeu c trials none of these have used rapid switching with rota onal s mula on.

[0007] In a 2018 review ar cle, O’Connell et al concluded: “There is very low-quality evidence that single doses of high-frequency rTMS of the motor cortex and tDCS2may have been short-term effects on chronic pain and quality of life but mul ple sources of bias exist that may have influenced the observed effects. We did notfind evidence of low-frequency rTMS,1[doi: 10.1002 / 14651858.CD008208.pub5.]2transcranial Direct Current Stimulation (tDCS)rTMS applied to the dorsolateral prefrontal cortex and CES are effec ve for reducing pain intensity in chronic pain. The broad conclusions of this review have not changed substan ally for this update. There remains a need for substan ally larger, rigorously designed studies, par cularly of longer courses of s mula on. Future evidence may substan ally impact upon the presented results.”

[0008] Although several peer reviewed reports have demonstrated benefits of magne c s mula on in trea ng brain anomalies, there is no consensus on effec veness. One feature of interest is that treatments described in the art lack provisions for a proper magnet return path. Reports of magne c s mulus for brain therapies encompass varied strategies. While some therapies have featured sta c magne cfields wherein a target is moved or manipulated through thefield, many recent therapies have used pulsed electromagne sm to induce an electric current within the pulsedfield zone that may include varied por ons of the brain ssues. The present inven on recognizes these varied strategies and improves on these and other therapeu c strategies to provide novel and effec ve ameliora ve therapies to specifically targeted regions of the brain and thereby to enhance a subject’s health and wellness. SUMMARY OF THE INVENTION

[0009] Generally, the present inven on features transcranial s mula on device with at least one pair of magne cflux generators as a circuit for inducing magne cfluxes within the brain. Such pair may be focused across a desired path in the brain that includes the area of interest. The pair may be movable to concentrate effect where thefluxes before and aNer movement intersect. Theflux genera on is supported by a data processor interface that outputs controlling instruc ons to one ore moreflux genera on circuits. Control is facilitated by data from an imaging tool that reports loca on of induced and responsive ac vity within the brain.Upon receiving instruc ve input from the interfaced data processor theflux genera on circuit(s) are ac vated to pulsate magne c s mula on ton one or more targeted areas or zones in the brain. The data processor works with experience based arficial intelligence (AI) that may access and use data from previous pa ents or subjects with similar diagnoses or issues, data from earlier sessions of the subject presently undergoing treatment, and instantaneous data from the current treatment session. The AI produces instruc on or algorithm to control each pulsa on session. The ini al frequency within a pulse cluster will generally be instructed in accordance with feedback data from subjects with similar diagnoses or issues. The strength (amplitude) of the pulse spike ini ally will consider the geometry of the subjects head, theloca on of the target to be s mulated, and experience data from previous subjects. The pulses within a cluster may present consistent amplitudes through the cluster, may start strong and ramp down, may ramp up, may have a paDern of increasing then decreasing amplitude, and may of course be interrupted if the data processor detects error or unintended neurological response. The AI in each session thus relies on data learned from earlier sessions of several individuals and / or data from the present individual from previous or instantaneous experience. The AI incorporates data indica ng what is happening and where the ac vi es are emana ng from, e.g., from an imaging device. The instruc ve algorithms controllingflux genera on thus are updated as the AI obtains addi onal learning and present inputs. Algorithms may be constructed for various effects, including, but not restricted to: determining the next pulse cluster instruc on, determining op mal loca on for aflux genera ng coil, determining a recovery interpulse interval, changing other inputs to a subject, e.g., when a sound or aroma is used to elicit brain ac vity. Data processing need not be consigned to a single chip. It may be dispersed, e.g., a coil may feature a dedicated processor ac vely monitoring and modifying its func ons; machinery for posi oning a coil may be augmented by a dedicated processor that may include its posi onal feedback; accessory components, such as Virtual Reality features may include accessory processors. Components that posi on one or more coils can be present with a track or arm that is interfaced with one or more conduc ve coils to move or retract each independently.

[0010] Repe ve Transcranial Magne c S mula on (rTMS) devices of the present inven on may incorporate sta c coils, not moved during t therapeu c session. However, a plurality of coils disposed orthogonally to define individual s mula on signal pathways., Switching s mula on for one pair to a second or third can be prac cally instantaneous, e.g., on the order of microseconds. By rapidly switching between coil pairs the s mulus can be concentrated at loca on(s) where paths intersect with lesser s mulus applied to paths leading to or from the specific target. Switching may be predetermined or may be con nuously updated from data processing and / or imaging devices serving as accessory components to the coils. Instruc on signals to the various device components are selected to avoid interference with data collec on and / orflux genera on. Imaging data inputs are protected by electronic signal screening that may include ac ve noise cancella on similar to processes used in audio devices , here applied to the electronic sinals with no sound waves being outpuDed. Screening / filtering may be physical and / or electronic. During s mula ons the response dataemana ng from adjacent ssue electrical ac vity is thus independently sensed from data relevant to s mulus strength from a coil pair. The data emana ng from brain ssue electrical ac vity indica ve of strength, frequency and / or source of response is thus separately processable from data rela ng to theflux genera on processes. All data may be incorporated into a machine learning process to contribute to the AI algorithm outputs.

[0011] A method to improve pa ent well-being though adjus ng their neurocircuitry is accomplished using a device of the present inven on. The subjects status is determined by analyzing signals from a subject’s brain to iden fy one or more ones or areas of abnormal func on. The area is inpuDed into a device of the present inven on, e.g., using coordinates obtained from an imaging device. These data are combined in a data processor to create a pa ent specific algorithm or to access a relevant AI algorithm rela ng to the individual subject’s brain and condi on(s) idenfied. These data and algorithms are compiled to instruct the data processor(s) signalflux genera on in accord with the algorithm(s). Following s mula on, response data are collected and outpuDed into the data processor(s) to op mally adjust the algorithm(s) subjects’ con nuing therapy.

[0012] In one example, a magne c circuit comprising two magne cflux inducing coils is situated over the head. The loca on of each has been predetermined using imaging methods, including, but not limited to: quan ta ve electroencephalogram MRI, CT, DTI, 3d-EEG, PET, etc. The imaging results for the subject are inpuDed into a processor that applies AI to instruct coil placement. Once the coils are placed current is applied to induce the desired magne cflux paDerns. The paDerns are con nuously upgraded or modified in accordance with algorithms produced with AI using real- me imaging feedback obtained during or immediately aNer each s mulus shot or me defined parameter.

[0013] Another preferred embodiment of this inven on features a magne c circuitry with at least 6 electromagne c coils to provide directed magne c induced s mula on to precisely targeted points-areas-zones of the brain. Conven onal therapies u lize mul -second on-off switching, a rather slow process that does not provide efficient 3-D targe ng. The present inven on features a device that provides effec ve 3-D targe ng by near instantaneous switching between orthogonally arranged magne c circuits. The preferred circuitry features a highly specialized conductors andflux generators that allow for rapid switching of the s muli with low heat genera on. Cycling between coil pairs can thus be accomplished on a microsecond scale to allow precise 3-D targe ng.

[0014] During therapy, real- me monitoring of the brain’s electrochemical responses to the therapeu c s mula ons provides feedback into the arficially intelligence enhanced control module direc ng repe ve or modified s mula ons. The feedback circuitry and resultant data is processed into and by a machine learning protocol using arficial intelligence (AI) that con nuously directs switching between each coil pair, while controlling amplitude, pulsing dura on, pulse frequency, interpulse interval, etc., based on the monitored (in real- me) electrical (transmembrane poten al) changes at the target.

[0015] The s mula ons are adjusted according to the ability of the cells at the targeted zone e.g., to release and recycle neurotransmiDers, maintain ion gradients, etc. The arficial intelligence algorithms are constructed through mul ple session on each individual where the AI incorporates each individual’s session into a learned base for guiding subsequent sessions. A library or collec on of learned experiences across a popula on of similarly affected pa ents is used for early treatments for each pa ent with the pa ent's individual responses to each treatment session gradually increasing in dominance. As the library grows, “similarly” will be refined to more closely match an individual’s demographics and neurologic manifesta ons. The con nuous monitoring provides important inputs to enable the AI algorithms to process, in real- me, feedback data for controlling the subsequent s muli. Each algorithm is designed to con nue machine learning during each session for each individual. This preferred capacity focuses the therapy to each individual’s present needs, i.e., taking into account the current state of the individual’s neurometabolisms, including, but not limited to: sleepiness, hormonal influences, general health, hydra on, fa gue, distrac ons, responsiveness of the targeted cells, excita on, etc. The in-session feedback and con nuous machine learning allows for shorter, more precisely targeted, and when desired, more frequent session scheduling.

[0016] A device / session using individual coils, groups of coils, expanding / contrac ng s mulus zones, banded zones, dynamic zones, coil pairs, etc. receives contemporary, preferably real me, feedback, applies the developed / selected AI protocols, and reconfigures algorithms for the current and / or a subsequent session to op mize desired / targeted effect. Op miza on includes, but is not limited to: pulse amplitude, pulsing dura ons, pulse frequency, rest mes, interpulse intervals, me of day (sleep schedule), distrac ng or focusing media (VR), shorter sessions, more frequent sessions, improved session effect, improved mul -session effect, an altered or different target zone, etc. Alternate or less op mized embodiments are also useful, for example, especially when an off site or delayed clinical review is desired the updatedalgorithms may be laterfinalized or quaran ned according to plan. Devices and their opera on protocols may thus operate in real me, near real me, or delivered at select delayed intervals. The device may be selected and / or programmed to update algorithms aNer a number of pulse sessions, therapeu c sessions, or at a specified interval. For example, a device may be set to update algorithms on scales as short as msec, but also over longer spans, e.g., sec, min, hour, day, week, month, season, year. AI producing the algorithms may incorporate learning rela ng to geo- and / or bio- rhythms, including, but not limited to: sleep schedule, last waking, last feeding, individual circadian rhythm, affect – such as MS, ADD, or ADHD, menstrual cycle, me zone travels, daylight, nighRme, me of day, menstrual cycle, pharmaceu cal type and schedule, hormonal – e.g. thyroid assay, even dal, lunar, seasons, sunspot paDerns. The AI is preferably enabled to access many databases in addi on to the individual brain ac vity.

[0017] Thus, this disclosure teaches improved therapeu c involvement in reforming brain func ons to ameliorate possible degrada ons, injuries, misdirected signalings, etc.

[0018] BACKGROUND DEVELOPMENT

[0019] Several early successes of magne sm in medicine were evident from trea ng, e.g., shrapnel wounds. In World War I prevalent in the Korean War. Electromagnets might be used to confirm shrapnel loca on as currentfluctuated in response to the shrapnel altering the induced magne cfield. Providing powerful at the me 4kilowaD magnets were used to treat soldiers who had been injured with steel or iron coated projec les or splinter fragments and shells or shell casings made with iron or ferro magne c alloys. The high high currents in these magnets produced a force strength sufficient to extract the foreign material(s). Less powerful magnets are useful for extrac ng metallic materials from eyes and skin. The directed magne c forces were less damaging that directed incisions (with a scalpel). And for non-ferrous metals, e.g., brasses and coppers, the shrapnel could oNen be removed with induced eddy currents in the materials.

[0020] Guillaume Duchenne is credited with the recogni on of electrophysiology in the 1800s. His electropuncture of muscles and connec ons to the central nervous system recognized the involvement of electrical currents in controlling many cell func ons. Nerves release neurotransmiDer chemicals into a synapse to induce an electrical current in the recep ve membrane and to ac vate the receptor cell’s ac ons. The common EKG test that many pa ents have received is a well-known example where ionic movements in the heart produce an electrical signal that controls the bea ng heart. Assessing electrical ac vi es innervous and muscular ssues is used in this and many other diagnos cs to this day.

[0021] Using magne sm to induce electrical currents and resultant electrophysiological responses soon followed Duchenne’s discoveries. An early example of a physiological effect due to a me-varying magne cfield was reported by d'Arsonval in 1896, phosphenes were produced when a volunteer's head was placed inside a coil driven at 42 Hz. Thus, techniques, methods and s mulatory devices have been progressing for more than a century.

[0022] At present, TMS apparatus are available in the art. For example, MagS m high- speed s mulator (MagS m Company Limited, Wales, UK)fiDed with a round coil (about 60 mm radius) has been proven in several trials.

[0023] At present, TMS apparatus are available in the art. For example, MagS m high- speed s mulator (MagS m Company Limited, Wales, UK)fiDed with a round coil (about 60 mm radius) has been proven in several trials.

[0024] As seen in one published example from the web as observed in January, 2023, Brainsway is one provider of Repe ve Transcranial Magne c S mula on Treatment (rTMST), for example for obsessive compulsive disorder, Parkinson’s Disease, Major Depression Disorder, and Anxious Depression. See e.g., www.brainsway.com / knowledge-center / safety-of-deep- repe ve-transcranial-magne c-s mula on-drtms-against-medical-refractory-symptoms-in- parkinson-syndromes-first-german-real-world-data-with-a-specific-h5-coil / .

[0025] “A 2017 review3found evidence that an unusual balance between excitatory and inhibitory neurotransmiDers may occur during depression, and that the imbalance can be reversed upon depression recovery. The imbalance between excitatory and inhibitory neurotransmiDers may be responsible for the reduc on in brain volume that occurs in depression according to a 2015 review4.

[0026] “In recent years, there’s been an interest in iden fying brain circuits involved in depression. A brain circuit is essen ally a network of neurons. Too much or too liDle ac vity in a given circuit may play a role in the onset of depression and other mental3Citation from Wilson: Lener MS, Niciu MJ, Ballard ED, Park M, Park LT, Nugent AC, Zarate CA Jr. Glutamate and Gamma-Aminobutyric Acid Systems in the Pathophysiology of Major Depression and Antidepressant Response to Ketamine. Biol Psychiatry.2017 May 15;81(10):886-897. doi: 10.1016 / j.biopsych.2016.05.005. Epub 2016 May 12. PMID: 27449797; PMCID: PMC5107161.4Citation from Wilson: Lener MS, Iosifescu DV. In pursuit of neuroimaging biomarkers to guide treatment selection in major depressive disorder: a review of the literature. Ann N Y Acad Sci.2015 May;1344:50-65. doi: 10.1111 / nyas.12759. Epub 2015 Apr 8. PMID: 25854817.health symptoms, according to 2021 research.5”

[0027] Sarah Wilson, PhD, Molly Burford: How Does Depression Affect the Brain? www.healthline.com / health / depression-physical-effects-on-the-brain (ci ng several review ar cles 2015-2021) Feb 22, 2022 version accessed Feb 2, 2023.

[0028] rTMS is applicable over a number of diagnosed dysfunc ons, including, but not limited to: Post-Trauma c Stress Disorder (PTSD), addic on and dependence syndromes, obsessive-compulsive disorders (OCD), cogni ve impairment (including Alzheimer’s Disease (AD), Mild Cogni ve Impairment (MCI), Lewy bodies demen a, cogni ve impairment in the course of Parkinson’s Disease (PD)), speech disorder(s) or delay(s), acute phase of both depressive and manic episodes in bipolar disorder type I and poten ally type II, schizophrenia, depressions, diabe c neuropathy, chronic central neuropathic pain, facial neuropathic pain, limb neuropathic pain,fibromyalgia, major depressive disorder, trauma c brain injury, prolonged coma, etc. The devices and associated methods provide improved therapeu c systems, for these and other dysfunc ons, over those previously applied.

[0029] ADHD and au sm are just two examples of diseases well-known in the art of diseases to which one or more parts grossly or more subtly have been tagged. Though each afflic on / disease may correlate to a par cular part, it will manifest in different specific groups of cells in different persons. Accordingly devices, systems and methods of this inven on include means for specifically targe ng the more dysfunc onal groups of cells. Addi onal applica ons of AI can be applied to further iden fy regions that might be expected to contribute to or suffer from the physically idenfied dysfunc ons.

[0030] Symptoms of post trauma c stress disorder (PTSD) have been aDributed to several key brain regions where altered func on is observed in PTSD. The amygdala, the ventromedial prefrontal cortex (vmPFC), and the hippocampus appear to have special involvements. The amygdala is an almond-shaped region centrally located in the brain that appears integral to the normal expression of emo ons, especially fear, and reac ons to aggressive behaviors, stresses, phobic encounters, and anxiety. The vmPFC appears to be involved in ac vi es such as "emo onal processing" and "decision making". The hippocampus is a large region that coordinates with other parts of the brain to process and retain memories.5Citation from Wilson:nLv, QY, Chen, MM, Li, Y, Yu, Y, Liao, H. Brain circuit dysfunc on in specific symptoms of depression. Eur J Neurosci.2022; 55( 9): 2393– 2403. hDps: / / doi.org / 10.1111 / ejn.15221

[0031] Askham, on the Spectrum News website, teaches:

[0032] “Children and adolescents with au sm oNen have an enlarged hippocampus, the area of the brain responsible for forming and storing memories, several studies suggest, but it is unclear if that difference persists into adolescence and adulthood.

[0033] “The size of the amygdala also seems to differ between people with and without au sm, although researchers from different labs have turned up conflic ng results. Somefind that people with au sm have smaller amygdalae than people without au sm, or that their amygdalae are only smaller if they also have anxiety. Others have found that au s c children have enlarged amygdalae early in development and that the difference levels off over me.

[0034] “Au s c people have decreased amounts of brain ssue in parts of the cerebellum, the brain structure at the base of the skull, according to a meta-analysis of 17 imaging studies. Scien sts long thought the cerebellum mostly coordinates movements, but they now understand it plays a role in cogni on and social interac on as well.

[0035] “Compared with their non-au s c peers, au s c children have significantly faster expansion of the surface area of their cortex from 6 to 12 months of age. In the second year of life, brain volume increases much faster in au s c children than in their non-au s c peers.

[0036] “People who lack all or part of one white maDer tract called the corpus callosum, which connects the brain’s two hemispheres, have an increased likelihood of being au s c or having traits of the condi on. The corpus callosum contains many of the long-range connec ons that extend throughout the brain; the fact that disrup ng those connec ons may lead to au sm traits supports the connec vity theory of au sm.

[0037] “Preschoolers with au sm show significant differences in the structure of mul ple white-maDer tracts, according to a 2020 study. Au s c toddlers and adolescents, too, show altera ons in white maDer throughout the brain.”

[0038] The amygdala is an important structure in the brain’s limbic system involved in how animals assess and respond to environmental threats. It appears to have a major role in evalua ng the importance of sensory informa on and promp ng an appropriate response. The amygdala is notably involved in regula ng emo ons, such as fear and aggression. Baseline responses to various inputs vary immensely between individuals. A Feb 2, 2023 ar cle in the Economist reported studies that recorded ac vity levels in response to various sensoryemo onal inputs. The amygdala, striatum, and parts of the cortex dealing with vision, hearing and movement were assessed using func onal magne c-resonance imaging. Different responses to different poli cally charged inputs were correlated with poli cal leanings. This provides clear evidence that tools are available to monitor both high and deep por ons of the central nervous system.

[0039] “Conversa ons” between nerves are mediated through chemical neurotransmiDers that are released by a sender neuron to one or more recipient (receptor cell(s)). The communica on interface between the neurons is called a synapse. An electrochemical signal, aka, an ac on poten al, is mediated by ions (charge carrying atoms). The movement of electrical charges carried by these atoms produces an electric current. At the synapse, the electrical s mulus ini ates release of the pre-synap c (sending) cell’s neurotransmiDer. As mul ple synapses are ac vated, a stronger signal can be observed. The present inven on monitors the ac vity, ionic poten als, bloodflow support, local metabolism, NMR changes observed, etc. to target and monitor zones within the brain as therapeu c targets. Within a specific brain ac vity center, different neurotransmiDers are oNen ac ve. The present inven on does not directly assess specific neurotransmiDer release, but may dis nguish between one or more based on the observable ac va ons at the ac vity center. ANer synap c ac va on, metabolism con nues. One well-known func on comprises removal / recycling of the neurotransmiDer chemical. Serotonin transporter (SERT) is highly conserved across species and is a prime target for SSRI drugs. Several dopamine re-uptake inhibitors are pharmacologically u lized to modulate dopamine ac vity, dopamine being involved in one’s ability to stay focused and controlling behaviors especially compulsive ac vi es. Star ng or stopping neuro-effec ve drugs or changes in dose may be useful for mapping target loca ons for further monitoring and treatments.

[0040] Mul ple communica on systems have developed as life has evolved. The number of neurotransmiDers used to communicate between brain cells comprises several score. For example, amino acids (building blocks of proteins) act as simple neurotransmiDers between cells, e.g. aspartate, glutamate, glycine, and γ-aminobutyric acid (GABA); simple molecules, e.g. NO, CO, CO2, H2S, etc., can act as neurotransmiDers or hormones; dopamine, epinephrine, norepinephrine, melatonin, serotonin, histamine, tryptamine, phynylethylamine, tyramine, octopamine, 3-iodothyronamine, and N-methylphenethylamine are several well-known compounds in a class of neurotransmiDer amines; endogenous cannabinoids such asanandamide exert some ac vi es as neurotransmiDers, but also as hormones; ATP and adenosine act as neurotransmiDers in some parts of the brain; several pep des including, but not limited to: oxytocin, somatosta n, substance P, and endogenous opioids have both hormonal and neurotransmiDer func ons. Two of the brain’s most common neurotransmiDers are glutamate and GABA. These appear to regulate how the brain changes and develops over a life me.

[0041] For example, when a person experiences chronic stress and anxiety, some of these connec ons between nerve cells break apart. As a result, communica on between the affected cells becomes “noisy,” according to Dr. Krystal. And it’s this noise, along with the overall loss of connec ons, that many believe contribute to the biology of depression.

[0042] A person with bipolar disorder experiences manic episodes, or unusually elevated moods in which the individual might feel very happy, irritable, or “up,” with a marked increase in ac vity level. DETAILED DESCRIPTION OF THE INVENTION

[0043] Numeric values are approximate, decimal or frac onal values are included in approximate expression unless context suggests otherwise. Counts of items are generally exemplary and not intended to exclude values not men oned. Ranges expressed include the stated limits (minimum and maximum) and all values between “<” and “>” have the mathema cal meanings of “less than” and “greater respec vely.

[0044] The devices and methods of this inven on is not restricted to just the conven onal applica ons of rTMS used in brain s mula on. RTMS may be combined with accessory s muli such as transcranial ultrasound, including Doppler ultrasound. Ultrasound can be applied as a targeted s mulus and may be used tofind or pinpoint therapeu c targets, to monitor effects of targe ng, to redirect targe ng, etc. The ultrasound monitoring and / or s mula on can be used concurrent with rTMS and provide real- me feedback. Transcranial pulsed s mula on featuring ultrasound in a neural s mula on technique can be applied as therapy used to non-invasively target and ac vate deep brain regions and op onally apply concomitant rTMS / TCS treatment.6

[0045] The applica on of rTMS does not involve electroconvulsive therapy (ECT). Seizures, a primary feature involved in the use of ECT to reset brain miscommunica ons, are avoided.6“The new treatment is an ongoing scientific development and requires clinicians to have specific neurological and methodological expertise, as well as knowledge of brain function,” explains Beisteiner. February 6, 2021 / / neurosciencenews.com / ultrasound-tps-neurology-17695 / .The devices, systems, and methods described herein result in reworking brain connec ons and structure for longterm benefit.

[0046] An early phase of the inven on involves tools and methods that iden fy targets for improved brain func ons. Normal brain func on involves communica on networks of many interac ng cells. Improved brain func on involve modifying the neurocircuitry by altering or changing connec ons in neuronetworks, improving communica on between cells, dele ng or adding synapses, changing modifying inputs at synapses, etc.

[0047] The subject may arrive with a diagnosis that can suggest loca ons in the brain that historically are associated with the diagnosis, for example a speech defect that historically has been associated with Broca’s area (frontal por on of leN (dominant) hemisphere, Brodmann areas 44 and 45). Many other cogni ve and motor dysfunc ons have been associated with specific zones or areas, However, human brains are adaptable to the extreme sugges ng that associa ons between dysfunc on and precise anomaly in the brain be confirmed for each subject individual. Though historical teachings can serve as a base for the machine learning and AI algorithms that suggest targets for therapy, the AI parameters are notfixed and precise suggested loca ons will be overridden when an individual subject provides different data.

[0048] A 2021 study of au sm spectrum disorder7looking at Brodmann areas 9, 46 and 47 “found that the number of neurons was increased and the number of astrocytes was decreased in layer II of all three prefrontal areas.” The authors noted this was “consistent with a failure of radial glial cells to shiN daughter cell produc on from neurons to astrocytes during prenatal cor cal development in au sm spectrum disorder.“ These recognized anatomical and developmental abnormali es are not targets when simply s mula ng or suppressing neuronal ac vity. Neuronal cells and such support cells can be addressed in accordance with the systems of the present inven on to ameliorate a large number of recognized dysfunc ons and detectable abnormal ac vi es.

[0049] Accordingly, brain scans of each subject are performed to specifically locate therapeu c target(s) for that individual. Scans and results from subsequent subject therapeu c events. A therapeu c event may be an individual treatment session or may comprise mul ple sessions on a single day, or repeated sessions over a longer period. The algorithm is updated7Carmen Falcone, et al. Neuronal and glial cell number is altered in a cortical layer-specific manner in autism. Autism: The International Journal of Research and Practice, 25:82238-2253, 2021. Abstract. doi.org / 10.1177 / 13623613211014408.specific to the individual, preferably prior to each cluster of magne c pulses, but may be updated in accordance with a session that includes several groups of pulses administered in a session. Algorithms will be improved for each individual as treatment “learning sessions” are compiled with associate results. Algorithms specific to an individual may take account of general learning from a group of individuals, but the individual learning sessions are weighted more strongly than average results.

[0050] For each poten al treatment plan, the brain is assessed prior to any pa ent’s therapeu c treatments preferably prior to each treatment a subject may receive. Brain “visualiza on” techniques such as, quan ta ve electroencephalogram, EEGs. MRIs, PET, Doppler ultrasound, etc., are examples of such imaging protocols known in the art that can provide results to guide targeted applica on of magne c pulses in rTMS. Addi onal s muli (excitatory or calming), such as sound, odors, images, moving visual images, tac le sensa ons (e.g., hap c clothing), may be used to morefinely target the primary therapeu c zone. ANer assessing an individual’s specific area(s) of dysfunc onal ac vi es, applying rTMS to the idenfied areas(s) may provide s mulus to induce improved ac vity or may be allied for calming influence. The amplitudes, frequencies, and pulse number are adjustable to concentrate therapy on the idenfied area, the intended effect, the targeted cells (e.g., astrocyte, neuron) to effect improved func on. In preferred embodiments, each s mulus session includes as series of s mulus clusters separated by “rest” intervals with no s mulus or s mulus in another zone or area. The S mulated por on thus reacts to the cluster both during the stmulus and a recovery period. The recovery period is preferably monitored, e,g., by EEG or cranial ac vity imaging, allowing automated / algorithmic determina on to ini ate each cluster.

[0051] For example, the pulse frequency is varied according to required effect. S mulatory rTMS (e.g., between about 5 and 20 Hz), induces increased cor cal ac vity. Where hyperac vity in a por on of the brain requires calming, rTMS is effec ve when set at a low frequency (generally < 1, e.g., 0.25 Hz ,but in some individuals in some brain loca ons up to about 10 Hz). The observed overlap mandates that frequency be adjusted in accord with the individual’s responses. Such treatment has been shown to induce a decrease of cor cal excitability in most trial subjects. Of course the therapeu c effect on each individual will be observed to confirm intended result. The AI algorithm will adjust one or more, preferably all of frequency, pulsing dura on, targeted zone size and shape, rest intervals between pulsing, number of total session, frequency of sessions, etc., to achieve the desired outcomes for each subject individual.Unconsciousness and seizure (according to literature, observed in less than 1 in a thousand subjects) are to be avoided. Parameters that appear to approach or induce either are to be avoided. Induced muscle contrac on when a relevant area of the brain is receiving s mulus is managed to avoid physical damage. Dura ons of pulsa ons can be varied, e.g, pulses may be applied 1 sec (at 20 Hz – 20 pulses), but oNen for longer periods, e.g., about 2, 3, 5, 7, 10, 12, 15, 20 seconds etc. Rest periods between pulsa on sessions can be varied for individual comfort and effect. For example, in some applica ons the rTMS may induce auditory, visual, olfactory, motor, etc. percep ons. Individual comfort should be taken into account. The interpulse individual allows the synapses at the targeted are to recover, e.g., clear or recycle neurotransmiDer, re-energize, re-establish ion gradients, etc. As an example, a series of 3 seconds of pulsa ons may be separated by recovery periods of about e.g., 10, 15, 20, 30 seconds before a subsequent pulsa on session. The rTMS sessions may each con nue for several minutes, e.g., about 5, 10, 12, minutes, etc. as tolerated by the subject. For example, an individual expressing symptoms of ADHD may tolerate shorter sessions than an individual exhibi ng symptoms of depression. A 12 minute session with pulsa on dura ons of 15 seconds interspersed with 25 second rests would feature 18 pulsa on sessions including a terminal rest session that might be include non-magnet energy such as ultrasound used to image changes in structure, circula on, etc. Amplitude is adjusted across the low T range, e.g., single digit, 2, 3, 5, 7, etc., T and, modified in accord with subject response. Peak amplitudes between about 2 and 5T are readily achievable. Magne cflux densi es canfluctuate rapidly. About 1T / µsec can be achieved with preferred devices. Thefields may reverse polari es, e.g., +yT to -zT as desired. In many instances z=y, but this may be varied. For convenient expression both z and y represent non- numeric values.

[0052] One preferredflux configura on has z or y = 0; The magne cfield is simply turned off and on. The magne c pulse from the electromagnet corresponds in shape to the charge change in the electromagne c coil. For example, theflux density absolute value may ramp up instantaneously,flaDen and ramp down instantaneously to form a square shape pulse. The flaDened zone may be varied in me as desired. Other shapes are available in accordance in the programming of the electric pulsing. A sinusoidal wave is a common example. Other examples include shapes that may approximate a child’s slide -with a steep ramp up and a relaxed down slope. The ramp and slope are not necessarily linear. The deriva ve of their shapes need not be constant. Thus pulse shapes can be of any shape for example those including, but not limited tocommon wave shapes such as: square, triangular, sawtooth, sinusoidal, but any varia on programmed into the wave generator. The base need not be zero; thefield can be biased, e.g., from a weak basefield, e.g., 0.2T with a pulse wave riding over it; perhaps symmetrically from - 2.3T to 2.7T. Thefield strengths and varia ons are at the discre on of the operator or programmer. The pulses may be unidirec onal in s mulus, e.g., only north or south magne c orienta on with a simple off mode subs tu ng for the minus or opposite s mula on in for example a sinusoidal or square shape paDerning.

[0053] The induced currents physically will originate normal to the magne cfield. Since the conductors, nervefibers, will receive the induced current to cause ionfluxes across the cell membranes and propaga on along an axon or other conduc ve path. The paDern of s mula ons can be unidirec onal pulsing where opposing coil pairs pulse with the same current direc ons. Pulses can be all posi ve - the poles do not reverse; can alternate (with a programmed waveform); can alternate between coils – in the alterna on paDern of choice as discussed later; can follow a paDerned pulsing, e.g., paradiddle, or other rudiment paDern. The nerve may respond to the alterna ng simple paDerns: 1:1, 2:1, 3:1, etc. ABABABAB, AABAABAAB, AAABAAABAAAB, a rudiment paradiddle: ABAA BABB, or other rudiment – for example – ABAAABAABABBBABB ABAAABAABABBBABB, The paDern is not limited to any simple or more complex rudiment.

[0054] The AI is empowered to op mize the algorithmic instruc on as learned from previous experien al teachings on similar subjects and / or the current subject and modified by the real- me feedback available during each therapeu c session. The reversingfields have a vibratory effect on the membranes seRng up a dynamic poten al across membranes that facilitates ion channel opening. The paDern may repeat in an alterna ng paDern with one or more sets or orthogonal coils. The alterna ng need not follow a balance with each coil set similarly ac vated. For example Coil set Z may receive pulsing (including any interpulse intervals) for me Tx; coil set Y may receive pulsing (including any interpulse intervals) for me Ty; coil set W may receive pulsing (including any interpulse intervals) for me Tw; etc.; where Ty and Tz may be equal or not equal; and Tw may or may not equal Ty and / or Tz, etc.

[0055] The skin, cutaneous fat, and skull vary immensely between individuals. Accordingly, it is advised that the effect of rTMS be used to calibrate intensity of the pulse. Evoked poten als are oNen used to monitor effect, especially for motor neurons. Magne c intensity is adjusted to evoke a poten al in a threshold frac on of pulses, for examples 50% to 90% at thediscre on of the therapist. A higher % threshold is assumed to affect a greater number of cells in the target zone. During repe ve therapy, the threshold % may be increased or decreased to op mize treatment as therapeu c effects are observed.

[0056] As an example, a 20 sec session may include a number of clusters, e.g., 3 clusters 4.5 sec each with afirst interpulse interval between clusters 1 and 2 of 2.5 sec, and a second interpulse interval of 4 sec. To further describe the varia ons the con nuous AI contributes to the subject’s treatment, an intercluster rest period may extend 10 seconds; the targe ng may be recalibrated taking into account data showing a less responsive zone. A second session Seconds, minutes, hours, days, weeks later) may feature afirst cluster of 7 sec, an interpulse interval of 3 sec, a second cluster of 3 sec, an interpulse interval of 3 sec, a third cluster of 5.5 sec, an interpulse interval of 7 sec, and a fourth andfinal session cluster of 11 seconds. The real- me data feedback and con nuously updated algorithmic controls of therapy will determine each, the frequency and numbers of each session.

[0057] Coincident with the s mula on, the device senses the electro-chemical-biological responses of the brain ssue. The frequencies of the s mula on and of the sensors are selected at different bands to permitfiltra on / resolu on of the electrical responses detected by sensor electrodes to ignore the s mula on frequencies. Such algorithm can include external factors, such as me available, insurance coverage, doctor's orders, etc.

[0058] Each session will be of length determined by the individual’s algorithm that may include considera on of external factors. One or more pre-session visualiza ons may be repeated as desired. For example, a PET and or MRI scan may be observed at the outset but only repeated on a periodic schedule or not repeated if therapeu c goals are achieved. The electronic feedback (e.g. EEG like data) provides intersession, intercluster and real- me data controlling each session and contribu ng to controlling subsequent sessions. Bulk data from a collec ve of pa ents can also be used to advise the session AI algorithm.

[0059] The AI session algorithms are individualized for each subject and session and cumula vely managed. The session algorithm is the product of several AI itera ons. Afirst level review and analysis is established in accordance with accepted protocols as applied to other pa ents.

[0060] Afirst level reviews literature, including raw data when available, to construct an atlas of the relevant brain. Thefirst level review will ini ate from the several atlases present in the literature for compila on and assimila on. Clinical reports highlight regions of the brainassociated with dysfunc ons or deficits can direct specific focus to subtle brain zones associated with deficits and compensa ons. The base atlas includes sub-atlases that use the raw materials to modify the skeleton atlas with characteris cs relevant to the intended subject. Thefirst level data include all types including, but not limited to: observa on, animal research, organoid, clinical, cell, pharmacological, abla on, etc.

[0061] Subject details including, but not limited to: age, skull shape, head size, handedness, previous imaging (MRI, CT, DTI, 3d-EEG, PET, etc.), neurologic symptoms, etc. The AI preferable creates a subject specific sub-atlas as a preliminary working model for each subject.

[0062] A second level of AI involvement applies therapeu c data from electrophysiology, TMS, and other interven ons. Some of these data were accessed for thefirst level AI review with weights adjusted accordingly by the AI during its learning phase. The second level AI is instruc ve in preliminary setup. Coil placement to best access the targeted zone(s), the repe ve intervals for that region and that subject, charge on the coils to induce the magne c fluxes, the wave shapes and paDerns, pulse dura ons, interpulse paDerns, session scheduling, and the like are suggested at this second level. The second level includes subject data from normal volunteers and clinical candidates as well as the level one AI product to formalize an original protocol for the intended subject.

[0063] A third level operates individually on each subject and subject session. The preliminary / original protocol is applied. Feedback from the imaging or subject reported result is processed to modulate the s muli, change the paDern(s), suggest electrode reposi oning, etc. Modula on of wave strength, pulse dura ons, and other s mulus feature are controlled by an AI produced algorithm in rel- me. Algorithms may be mul -component, i.e., comprised of sub- algorithms. A sub-algorithm may determine a signaling paDern to be applied to the subject in a therapy session. It may interface with a second sub algorithm that translates the intended signaling paDern inot machine codes appropriate for relevant components of the magne c circuits. The machine codes are distributed appropriately to the circuits to be ac vated at mes that may have been arrived at in conjunc on with another sub-algorithm. The magne c circuitry incorporates interface modules or connec ons to permit manual or AI developed algorithms to instruct ac va ons and func ons of components of the intended magne c circuit in the device. Magne c circuitry may include a feedback sensor that measures magne cflux delivered by a circuit and serves to modulate outputs in accordance with intended therapeu cor measuring s mulus.

[0064] A fourth level monitors the feedback from the improving s muli to suggest pausing orfinalizing treatment at thefirst zone, perhaps in favor of a second, third, fourth, etc. zone to treat region(s) that interact with the original target. In some instances the original target will receive subsequent sessions of s mulus.

[0065] During therapy, a pulse or series of pulses is administered through afirst magne c circuit. A pulse or series of pulses is administered through a second magne c circuit. A pulse or series of pulses is administered through a third magne c circuit. The signals to the three circuits are rapidly interplexed across the three dimensions rapidly switching amongst the pairs with the result that the s mula on from thefirst circuit is coincident with the other circuit’s s muli on the scale of biologic response. i.e., a cell’s depolariza on or other membrane response is ini ated across thefirst beam, the second beam intersects with this beam con nuing s mula on only at the intersec on The third beam reinforces this s mula on. Zones receiving only one circuit’s s mula on are only slightly perturbed at a level well below the threshold for response. The system can func on with two circuits when desired. However, the three circuit embodiment is preferred because thefirst and second circuits can therefore be less energized decreasing the risk of s mula on in unintended zones.

[0066] In common prac ce according to the FDA example8, the motor threshold level is the minimum s mulator seRng, in Standard Motor Threshold pulse or series of pulses is administered through afirst magne c circuit (SMT) units, that induces an observable motor response by the pa ent in 50% of the applied pulses, usually as observed by movement of the thumb. “MT level” is determined with the rTMS treatment coil posi oned over a specific loca on within the motor strip, called the motor threshold loca on (MT loca on). The MT loca on may be used as an anatomic reference point for naviga ng the coil to the rTMS treatment loca on. The MT level is used as a reference point for seRng the rTMS treatment intensity, usually expressed as a percent mul ple of the MT level, e.g.120% MT. According to the FDA, rTMS is reasonably safe with mild side effects when performed in compliance with the recommended safety guidelines. The devices, processes, systems and methods of the present invent increase safety and reduce side effects (off target effects) in comparison to conven onal8Guidance for Industry and Food and Drug Administra on Staff | Class II Special Controls Guidance Document: Repe ve Transcranial Magne c S mula on (rTMS) Systems. Document issued on July 26, 2011.technologies.

[0067] As a base example, in a 2010 J.Clin. Psychiatry paper, Boggio, et al reference a 1998 Grisuru, et al report that used 0.3 Hz s mula on “in lowering the core PTSD symptom of avoidance as well as soma za on and symptoms of anxiety and depression.” Boggio also cites addi onal references as demonstra ng effec ve treatments at 1 and 10Hz for repe ve TMS is an effec ve treatment tool. The 2010 Boggio paper reported an apparatus using afigure 8 shaped coil with each wing having a 7cm diameter.

[0068] The present inven on expands upon teachings, e.g., of Boggio, by incorpora ng mul ple coils for magne c induc on in a device configured tofit over a subject head. Coils may be of a size much less than the 7cm of Boggio allowing the device to incorporate mul ple coils spread over the dimensions of the head encasing device. Such device may be of any configura on that places the coils in proximity to the cranium. The plurality of coils are used to provide a triangula on effect to effec vely and specifically target the regions idenfied for therapeu c interven on with minimal effect in non-intended areas. Smaller coil sizes can concentrateflux density since the generators are more compact. Coil diameters of about 100mm produce acceptable concentrated output. Height (thickness of the coil) between about 20mm and 100mm, preferably of an amorphous metal for maximizedfiled strength, produce a strong concentratedflux density.

[0069] The coil ac vi es are directed by a power supply providing the electric power (pulses). The output of the power supply to the magne cflux genera ng circuit components is controlled in accordance with a session specific algorithm generated by AI in real me from base data and instruc ons from previous “learning” sessions and modified from the real- me sensor feedback in an ongoing session. Accordingly a data processor operates to combine AI or raw or processed data with real- me output from current session feedback sensors to formulate a session and / or a s mulus ac vity within a session algorithm. This algorithm is inpuDed into the module controllingflux genera on.

[0070] A data processor may comprise installed protocols for AI and data for reprocessing or may receive such inputs from an accessory device or channel. Mul ple rou nes or subrou nes may be incorporated within or available to the algorithm outpuRng processor. The processor has in input for obtaining the real- me progress data of response in or from the brain. Op onally addi onal data, e.g., subject restlessness, breathing, breath or skin temperature, cardiac data, perspira on, sleepiness, etc. can be available to the AI protocol(s) asthe processor formulates and outputs ac vity and / or session algorithms.

[0071] The inven ve device that sports the coils may also incorporate components for imaging the brain in the same unit in order to precisely map coil target zones. The coil containing headpiece might be ghtfiRng headgear or, for example, a frame, pod or cone that fits over the head and from which s mulators - which h may be for imaging, sensors that may receive imaging signal and / or therapeu c coils are dispatched. The live imaging apparatus may be available as an accessory inclusion or device. The coil containing headpiece might be ght fiRng headgear, or, for example, a frame, pod or cone, thatfits over the head and from which s mulators - which may be for imaging, sensors that may receive imaging signal and / or therapeu c coils are dispatched to approximate the skull.

[0072] The term “image” does not require a visual representa on. In this context it is simply meant to be a recording of the brain ac vi es or structures mapped in a format that permits accurate reading and targe ng. The image can be purely mathema cal. The image may deviate from strict 3-D representa on, e.g., mapping the brain por ons by strength and direc on (source) of signal to target the therapeu c zone(s). The brain is imaged, e.g., using electronic, sonic, electromagne c waves (visual on non-visual spectrum), atomic resonance, etc. to reveal structure and ac vity zones. Several imaging tools may be coordinated to produce the therapeu c target map, for example, x-ray and EEG may be used to coordinate a physical structure with ac vity emana ng therefrom.

[0073] The imaging may result in areas of the brain that appear hyperac ve or hypoac ve in comparison to normal. The imaging may be used to monitor therapeu c progress when images are compared over a therapeu c me course. To aid the imaging process, s mulants, such as tones, cries,flashing lights, visual images, music of various formats, smells, tac le s mula on (touch, wind, hap c garment, etc), foods, select me of day (e.g., for sleepiness), etc. can be used for circumstan al dysfunc ons (e.g., PTSD). The subject is preferably adequately hydrated (for repeatability) and reduced random variance of results from session to session.

[0074] The systems and methods described herein relate to related inven ons for improving central nervous ac vity, brain ac vi es. The brain is a complex structure comprising mul ple interac ng substructures.

[0075] For example, the frontal lobe (frontal cortex) plays a significant role managing planning, organizing, strategizing, paying aDen on to, remembering details, etc. Our frontalcortex is recently evolved and cons tutes a compara vely large frac on of our whole brain. The leN and right lobes make up a significant por on of what we know as our “thinking” brain, where logical reasoning skills are located, among other ac vi es such as motor sensa on, planning, etc. In the frontal lobe, about 30 % of the brain is characterized as the prefrontal cortex. This structure has been determined to be involved in important life balancing func ons, including, but not limited to: delaying instant grafica on, modula ng emo ons, problem solving, future plans, aDen on, choosing focus, adap ng to present and expected situa ons, etc. Behind the prefrontal cortex, the frontal cortex harbors the motor cortex including regions dedicated tofine skills, coordinated movements, wriDen word, adversive, aversive, ac vi es, etc.

[0076] ADHD exhibits several problems including, but not limited to: inaDen veness, impulsivity, and hyperac vity, that are associated with ac vi es of the prefrontal cortex. Other areas may also be associated. But simply recognizing the precor cal involvement would include probably 80% or more of the prefrontal cortex that may not lead to ADHD. And different persons exhibit different ADHD traits to various degrees. Those whose manifesta ons favored one or more of impulsiveness, forgeaulness, inaDen veness, hyperac vity, ease of distrac on, etc. will involve different degrees of dysfunc on is different specific parts of the prefrontal cortex and / or other areas in the brain. What sets this general area apart from most others in terms of ADHD research is that it has been shown to be rela vely smaller in those with ADHD compared to people without the disorder. The re cular ac va ng system (RAS) has been indicated as affec ng or being affected by ADHD. The limbic system and basal ganglia may also be involved in many ADHD incidents. Major Depression Disorder (MDD) is also oNen associated with por ons of the Prefrontal Cortex as well as the amygdala, thalamus, and hippocampus, por ons of the brain whose shrinkage correlates with MDD. Higher glucose metabolic ac vity in the anterior insula as measured using PET was associated with successful pharmacologic interven on while successful behavior therapy was associated with decreased glucose metabolic ac vity. Ac vity measurement using an imaging tool is thus recognized to be an important tool for assessing brain dysfunc on.

[0077] In general historical development of the understanding of our brains, many parts have been given names associated with their loca ons and structures. Important cultural ac vi es have been associated with some well-idenfied structures. Accordingly, prime or preferred therapeu c targets may be selected from the hippocampus, the amygdala, thethalamus, the re cular ac va ng system, the frontal cortex including prefrontal cor ces, and cerebellum. The hippocampus has been idenfied in support of memory, learning, naviga on, and spacial percep on. The thalamus carries coordina ng signals from the cerebral cortex, the brain’s outer layer, to the brain stem at the brain’s center. The amygdala has been associated with memories and emo ons. The prefrontal cortex interacts on an emo onal level with the amygdala and is involved in cogni ve func oning, and impulse control. The re cular ac va ng system (RAS) interplays with the cogni ve func oning and impulse in control of obsessive compulsive behavior. Accordingly, this inven on recognizes that mul ple therapeu c zones may be targeted in a single session or in series across mul ple sessions. ADHD in many subjects shows abnormal movements or “motor ac vi es”. The cerebellum is the sec on of our brain integrately involved in coordinated motor func on. It is located some distance from the prefrontal cortex in an area located roughly behind and below the ears.

[0078] Cerebellar involvement in ADHD may be as its role as a regulator or “governor” for beDer control over motor movements, balance, coordina on, etc. Not every ADHD subject will express obvious coordina on issues. Accordingly, each prospec ve pa ent should receive screening involving mul ple brain regions.

[0079] The precise anatomical regions vary from person to person and ac vi es oNen overlap across regions. ANer all the brain organ comprises between 50 and 100 billion interconnec ng neurons and their associa ons with about the same number of glial cells (microglia, astrocytes, oligodendrocytes, and ependymal cells) that support and modify neuronal ac vi es in mul ple ways. Altered ac vi es (including, but not limited to: ion balance, neurotransmiDer scavenging and recycling, blood supply, hydra on, ATP and Ca++release, synthesis of cerebral spinalfluid, mechanical structure, neuronal repair and removal, signal modula on, axon culling, etc.) of glial cells and abnormali es in their numbers have been correlated with several diagnosed brain dysfunc ons.

[0080] The present inven on does not depend on iden fying the neurotransmiDers involved in the targeted dysfunc on. It is brain ac vi es at idenfied zones that are targeted and monitored. However, although prac cing the inven on does not require iden ty of the one or more neurotransmiDers party to the targeted dysfunc on, when a specific region is targeted or a subject has been shown to be reac ve (posi vely or nega vely) to a neurotransmiDer, hormone or compounds known the affect such, pharmaceu cal interven on modifying the idenfied compound may be employed to aid targe ng or to augment therapy.

[0081] To proceed with remedia on therapy in an individual, a targeted func on is selected. For example, for post-stroke therapy, the stricken zone and / or its remaining func oning neuro-connected centers may be mul ple targets. MRI, PET, 3D-EEG, or other imaging protocols are useful for selec ng targets. S mula ng the stricken zone enhances nerve repair processes. S mula ng centers that normally transmit signal to the stricken zone can induce recipient nerves present there (even if efferent pathways are not apparent) to ini ate or enhance repair processes. S mula ng centers that receive nerve impulses from the stricken zone can ac vate loops feeding back to the stricken zone.

[0082] Illustra ve Example

[0083] A targeted func on or diagnosis is selected. For example, for post-stroke therapy, the stricken zone and / or its remaining func oning neuro-connected centers may be mul ple targets. MRI, PET, 3D-EEG, CT, PET-CT, Doppler, or other imaging protocols are useful for selec ng targets with or without contrast. S mula ng the stricken zone enhances nerve repair processes. S mula ng centers that normally transmit signal to the stricken zone can induce recipient nerves present there (even if efferent pathways are not apparent) to ini ate or enhance repair processes. S mula ng centers that receive nerve impulses from the stricken zone can ac vate loops feeding back to the stricken zone.

[0084] Eltagy, et al provides one exemplary teaching demonstra ng the availability of aspects of TCS treatments in conjunc on with imaging to accurately target zones for remedia on. Positron Emission Tomography (PET) is a precise method for mapping brain ac vi es. Posi onal electroencephalography is adequate for direc ng the zones and intensi es of magne c bursts used for TMST.

[0085] Applica on of soundwaves, ultrasound, has two applica ons in the present inven on. The ultrasound itself can be applied as an augmen ng s mulus, i.e., a s mulus applied concurrent with the TMST, in the interburst interval, and / or ion a separate session. Ultrasound is also available for imaging, e.g., to monitor and confirm progress in the applied therapy. Where specific func ons are targeted for remedia on, such as hand, the relevant homunculus hand would be the selected target. Confirma on of the cor cal target can be achieved by monitoring hand s mula on or motor func on while recording and iden fying the cor cal zone responsible for the sensa on or ac vity. Similar prac ce can be performed over the cerebellum when the subject would benefit. Where centers may be changed by accident and recovery or from a congenital condi on, the compensatory loca on of the center might beconfirmed by elici ng ac on by the subject. For example, where a subject may have compensated for a congenital defect, e.g., with dysphasia or dyslexia, the compensa ng zones are confirmed by, e.g., asking the subject to read and / or speak.

[0086] ANer iden fying the target zone and result, e.g., ac va on or calming, the rTMS commences.

[0087] Delivering the magne c pulses can be through a coil or coils strategically posi oned over the scalp to magne cally target the selected zone(s). Such coils may reside over and / or around the head where the head is sta onarily placed in proximity to a frame suppor ng coils. Coils may be in aflexible cap or other covering thatfits over the subject’s head. A mask or container surrounding the head may hold the coils for therapy. Mul ple coils may be incorporated into a device, with specific coils being selected for a specific subject or specific subject session.

[0088] VR programming is selected to augment the desired effect of the TMS. For example, when a calming rTMS is used, calming sounds and scenes are featured in the VR outputs. The panop c device is preferably configured to provide an aroma therapeu c oil e.g., an oil selected selected from essen al oils including, but not limited to: rose, lavender, ve ver, basil, sage, frankincense, geranium, lemon grass, lemon balm, chamomile, ylang ylang, patchouli, marjoram, melissa, rosemary, bergamot, etc. The prac oner is advised to test each subject’s response to one or more candidate oils because individual’s experiences may have associated specific events, stressful or relaxing with an oil or combina on. Aroma therapy may be enhanced by or replaced with one or more other calming or excitatory influences, e.g., music, visual scenes or paDerns, masking such as a white noise, etc. As with the oils, such therapeu c contributors should be confirmed for intended effect with each subject.

[0089] The format of the device is notfixed. For example, a par al or full body massage chairfiDed with a VR display is one embodiment, e.g., a Virtually Reality (VR) mask or egg, structure may be used. The massage may be coincident with the pulse therapies, may be constant during and between pulsed therapy bursts, may turn on or increase between bursts, etc. Massage may involve human interac on, for example with a masseuse whose presence may provide physical and / or emo onal s mula on to assist in therapeu c screening and / or effect. Massage may be by human or mechanical means. It may comprise skin on skin; glove on skin, liquid or gas on skin, etc. For example, a pneuma c tube or sleeve may be disposed on a body part, e.g., a limb – arm or leg, an extremity, e.g., foot, hand,finger(s), toe(s). Thepneuma c accessory may simply pulse its en re massage zone or may be programmed to pulse along its length. The cap or head covering may incorporate physical simula on as well as provide the magne cflux s mula on. The “massage” may be intertwined with VR or ER to enhance therapy.

[0090] Hyperoxygena on, e.g., using a hyperbaric chamber, a mask delivering enhanced O2concentra ons in concert with aromatherapeu c delivery, an enclosed VR module ouaiDed to control O2concentra on, etc. In place of on in concert with a massaging module, embodiments may include apparel such as gloves, vests, leggings that provide augmen ng sensa ons, e.g., during a VR adventure, as addi onal s mulus to synergize with the TMS bursts, etc. For example, sensory (hap c) gloves may coordinate with the VR adventure for increased reality, may augment the TMS bursts to coordinate physically s mula on with the magne c. VR outputs, auditory, visual, olfactory, etc., can be integral with sensing and / or s mulus devices, systems, or components. For example, a helmet can cover the head, provide sound and visual outputs prior to and / or during sensing (imaging), which may be coincident with, interspersed between and / or pre- or post- therapeu c session(s). A preferred sensing device is a device that func ons in real- me during or in close me proximity to s mulus. A 3d-EEG system is one well-known such device that is capable of providing feedback during a s mulus session at mes between s mulus ac vi es and during ac vity where frequencies are selected to permit differen alfiltering. The in session feedback is considered by the AI, especially at the third level to adjust the algorithm for subsequent s muli.

[0091] One embodiment incorporates a massage chair inside an egg shaped pod that uses its walls as a screen for VR projec on while the pod delivers g forces that are associated with the projected images. VR may befiDed in a module separate from the electromagne c coil pods.. A device sta on, when desired, may include back-up health features such as humidity control, an iv drip, HR and / or BP monitoring, etc. Accordingly, devices of this inven on may be incorporated into or associated with larger or accessory structures or features. For example VR or ER (Enhanced Reality) may feture components reminiscent of the subject’s past experiences. For example, one or more sensa ons, cogni ve or physical environments, stress condi ons, etc., may be suggested or duplicated to mimic a calm or stress as determined by the prac oner to guide the brain towards achieving desired therapeu c effect.

[0092] The present inven on provides improvements over previous therapies that have incorporated magne sm in aDempts to correct or ameliorate undesirable altera ons orabnormali es in brain func ons. Early aDempts to correct brain anomalies used sta c DC magne cfields. The surface s mula ons common to the art while directed at a par cular por on of the head of brain were not focused through a magne c return path. The incorpora on of at least two interplexed magne c s mula on pathways provides accurate targe ng specific to the intended zone / area. Three interplexed circuits provides an extra margin of safety with regard to off-target s mula on. If desired, addi onal circuits can be included in the device. Some mes not all the circuits will be ac ve in a given session. In situa on with dormant circuits, the ac ve circuits would be those posi oned with op mal pathways to the targeted zone(s) are selected for ac va on in a par cular session. Rather than an cipate providing hardware that allows for posi oning by selec ng specific pairs, the device can be configured with movable coils that may be set prior to a session or might be tracked for movement during a session. Mul plexing becomes more difficult with each addi onal channel requiring shorter bursts from each channel. In some cases, one or two circuits may be favored with a third , fourth,fiNh, etc., channel being ac vated fewer mes than the preferred channel(s). For example, an ac va on order may be: 1, 2, 3, 2, 5, 1, 2, 7, 6, 2, 1, 2, 3 or any varia on as determined by the AI algorithm using feedback for the par cular subject session and device.

[0093] Coils may be refined by inser on of a ferro-ac ve pin or plug projec on in the center of the coil. In one example, a quadrupole is situated to provide a magne c beam. The projec on outcrops the magne cfield to a pinpoint dimension. The projec ons, rather than the coils contact or are made closely proximate to the scalp for a more reliable focused stronger signal.

[0094] Example

[0095] A subject presents with a behavioral abnormality or func onal deficit rela ng to nervous func on origina ng in the brain. A brief medical and / or experien al history is referenced or obtained. The subject’s head is brought into an analysis zone either by moving the subject or by moving an imaging device or system to surround the head in a manner to provide 3-D func onal imaging of brain ac vity. The history may be instruc ve in efficient placement of imaging tools. An image is obtained to indicate zones or areas of the brain where cellular ac vity is abnormal. An outside s mulus may be applied to poten ally ac vate or amplify the historical disorder. For example, visual images may be used to create percep ons that might alter brain ac vity to emphasize or increase the abnormal ac vity. For example, aninstance (visual, sound, olfactory, etc.) shown in the subject’s history to predispose a panic aDack may be presented to iden fy the areas ac vated and thus to be targeted for desensi za on. Conversely, a calming, e.g.,flowing image or calming sound may be used to strengthen the subject’s capacity to remain sedentary for the therapy.

[0096] The imaging device can also incorporate the magne c coils used to deliver therapy. A different imaging system may be used during the therapeu c sessions. Preferably, the session feedback imagers are equipped withfiltering hardware or soNware to separate the magne c therapy from the brain ac vity signals. Feedback may be coincident with the therapeu c signals and con nue during breaks such as interpulse intervals. When feedback is desired during the pulse phase, not the interpulse phase, the frequencies of the therapeu c pulsing should be outside those of brainwaves. For example, some epilepsies feature a 3Hz neuronal ac vity as monitored on EEG. When feedback is to be collected during pulsing sessions, all the relevant frequencies of the ac ve device must be selected to avoid interference.

[0097] The orthogonally situated coils that may feature accessory hardware to focus or concentrate a magne c beam are not universally ac vated. The system comprises at lease two sets of coils so that the signals can be made to cross at the targeted zone. Three pairs of coils can be used to more robustly concentrate therapeu c s mulus on the zone coordinates determined by the algorithm developed by the embedded AI from the subject histories, imaging and coil characteris cs.

[0098] A preferred AI con nuously adapts with each subject session. Early applica ons with devices of the inven on use Ai based on data available, including contemporary and historical literature to iden fy trgeted areas and s mulus formats. Data from subject sessions are periodically added into the learning set(s). Sets may comprise subsets with weigh ngs of data results specific to, e.g., to age, diagnosis, handedness, etc. The AI operates in accord with conven onal machine learning paradigms like LLM where paDerns are learned to predict subsequent items. The electronic signals from the brain act as words in do on the LLM models. The models predict the next word (data block or signal) based on previous paDerns. Simply described, the AI looks at its learning library, idenfies features relevant to current signal inputs from the subject, e.g., EEG readings, medical history, historical data from that subject and similar subjects, diagnoses, etc., then queries the AI system with suggested algorithm steps and analyzes predicted outcomes. In preferred prac ce mul ple ini al steps are proposed to the AI system which deselects ini al steps with less advantageous outcomes. The AI proceeds step-by-step to form the algorithm that ac vates the s mulus coils. Where coincident feedback is available, the AI con nuously adapts or updates the algorithm output to op mize subject treatment outcome. The AI operates for each subject session and when a subject is slated for mul ple therapeu c sessions is beDer enabled as experiences are incorporated into the AI protocol. The AI thereby incorporates past results to indicate expecta ons in sessions to come. Past and con nuing results are considered as the current session therapeu c algorithmic protocol is delivered to the s mulus coils. In a preferred prac ce, feedback signals repor ng neurologic response to the s muli are compared with content in a learned database relevant to the instant subject, with individual subject historical progression, and with in session feedback. Such broad considera ons by the AI for the instant algorithms op mizes each session for the subject. For example, the AI may produce algorithms during a session that might skip or repeat s mula ng a zone or ac va ng a coil pair in session when feedback determines the op mal s mula on paDern8ng in the me alloDed for the session and planned future sessions.

[0099] Some embodiments may comprise at least two sets of coils so that the signals can be made to cross at the targeted zone without refiRng the device on the scalp or moving coils to focus through different cranial angles. E.g., three pairs of coils might be used to more robustly concentrate therapeu c s mulus on the zone coordinates determined by the algorithm developed by the embedded AI from the subject histories, imaging and coil charac- teris cs while feeding lessflux in in undesired paths than would occur if a singleflux pathway were repe vely ac vated. Other formats for employing mul ple paths to focus on a target are available. For example, a helmet or structure covering or surrounding the skill can be ouaiDed with a system to allow reposi oning of coils or coil pairs around brain. The movement may be controlled as desired by the prac oner, e.g., gear-like tracks inside a cap or frame, cables to move coils along tracks, magne c or electromagne c pulses to arithme cally drive a coil to its new desired loca on over a targeted zone on the skull. Coils can also be ouaiDed on robo c arm-like structures. The controlling algorithm liNs the coil(s) off the head, transfers the coil(s) to a zone above the new desired path site, and lowers the coil(s) to the skull prior to ac va ng the coils. Addi onal embodiments may feature orthogonally situated coils that may feature acces- sory hardware to focus or concentrate a magne c beam to ensure other unintended coils are not uninten onally ac vated. The system comprises at lease two sets of coils so that the signals can be made to cross at the targeted zone. Three pairs of coils can be used to more robustly concentrate therapeu c s mulus on the zone coordinates determined by the algorithmdeveloped by the embedded AI from the subject histories, imaging and coil characteris cs.

[0100] The algorithm adjusts the ming - length of pulsing for each pair, the switching bet- ween pairs, the intensi es of each pair, frequencies of pulses within a cluster of pulses, recov- ery intervals, the pulse amplitudes and shape e.g., just posi ve at a given coil and nega ve at the other - sinusoidal, ramped, squared, etc., frequency of pulsing, number of pulses for each pulse session for each pair, ac va on – length of me each packet of pulses is delivered from each coil, the amplitude of each s mulus signal within a pulsing cluster, the switch rate between coil pairs, etc. Each pair may be separately and dynamically controlled, For example pair x may deliver pulses at an amplitude a for ~20msec, before switching to pair y that may deliver pulses at an amplitude b for 3msec, followed by switching to pair z that may deliver pulses at an amplitude c for ~12msec, before switching to pair y at amplitude b’ for 11msec. The s mula ng paradigm comprises rapid switching between orthogonally arranged magne c circuits, where each pair undergoes of magne c circuits undergoes on-off cycling in concert with other orthogonally arranged pair(s) at a rate where the targeted area receives the signals from a second pair while the ssue is responding to the signal from thefirst pair. The switching of the physical signal can be more rapid than the biologic signal response. A second cycling and subsequent cyclings amongst the pairs oNen immediately follows. Rapid switching between coil pairs allows con nuous delivery of s mulus to the target while delivering below threshold energies to the non-targeted zones that may be in the path of a single pair. Pulsing me or cluster me length for each pair ac vated is set by the AI in adjus ng the algorithm. For example, afirst pulse dura on may be 400msec, a second 300msec, a third 122msec. An interpulse or cluster recovery interval may be called for aNer a preprogrammed period of me or a max dura on determined in the algorithm based on previous experiences, pa ent comfort or safety concerns. For example, an interpulse / intercluster interval may be mandated to occur aNer 3sec, 2sec, 1sec, 800msec, 736msec, 660msec, 500msec, 400msec, 370msec, 333msec, 300msec, 250msec, 220msec, 200msec, 100msec, 50msec, 30msec, 20msec, 18msec, 15msec, 12msec, 10msec, 8msec, 5msec, 3msec, etc. These expressed numbers are arbitrarily selected as examples; the algorithm will instruct he device with specific melengths, frequencies, amplitudes, etc. The arbitrariness of the specific instruc ons, of course, is not restricted to integer numbers. The algorithm instruc ons may include or be overridden by safety criteria, e.g., length of a pulsing session, temperature measured on the subject, noise or movement made by the subject, amplitudes of a signal, temperature in the circuitry, etc. Control circuitry isavailable that can deliver pulses with µsec up to several second dura ons. Pulse frequencies of any frac on of the dura on are therefore available in a range from the µsec to several seconds. Frequencies in a midrange of these extremes more closely match observed biological frequencies at the cellular level. The Litz conductors minimize hea ng for longer s mulus sessions. Interpulse intervals therefore can be selected by the AI to op mize therapeu c effect for the subject without significant restric ons rela ng to heat discomfort or to damage to ssue or equipment of concern when using conven onal TCS and / or rTMS circuitry. The therapeu c methods of the present inven on feature a diagnos c pre-screen. The pre-screen may be mul - dimensional, I.e, involving one or more targe ng diagnos cs such as MRI, PET, 3D-EEG, or other imaging protocols as well as the pre-screen for poten ally problema c material. The pre-screen may involve a rest state and / or may involve s muli to assist diagnos cs.9

[0101] The AI is configured to adjust the algorithms as suggested by the feedback data. For example, an intensity / amplitude may be adjusted to improve balance of signals at the target; the pulse frequency can be adjusted to beDer ac vate or suppress cellular ac vity at the target and may be configured to target specific cell types at the target; the number of pulses from each node and in some cases pulse frequency or shape may be varied during a session. The dura on of a pulse session as controlled by the algorithm may involve ac va ng a pair a single me, two mes, 3, 4, 56, 7, 8, etc., mes in a session. Pulse sessions are separated in me by interpulse intervals, also adjusted in real- me by the AI as it con nuously updates the algorithm based on the feedback data. The sessions are interrupted by interpulse intervals that allow the ssues to reset, e.g., strengthen or reestablish ion gradients, turnover receptors, recycle neurotransmiDers, etc. Interpulse. A dis nct series of coil pairs may be ac vated at different cycles and / or selected in session to more efficiently align with axonal direc on.

[0102] A preferred device configura on features mul ple pairs, e.g., 3 pairs of orthogonal coils with Litz wiring to reduce hea ng from proximity effect and skin effect that increase with higher frequencies. An alterna ve configura on can use hollow, e.g., square, conduc ve, e.g., silver, copper, etc., windings to reduce proximity / skin effects to reduce need for cooling. Cooling with purified, deionized water, e.g., RO18 water with an -leach addi ve to protect 9. The present inven on employs a varia on on these methods but must be cognizant of poten al unknown, implanted, or unrecovered metal substances that might be moved or drawn by the magne c forces. Before applica on of the therapeu cfields a scan is advised to iden fy foreign or magne cally influen al materials that may affect or be affected by the therapeu c applica ons of s mula ng magne c currents.conductor and avoid ions escaping into the low conductance – high resistance water. An amorphous metal band / ribbon is the preferred conductor for connec ng the coils of each pair. Several cobalt based amorphous metallic alloys are available for this job and can be formed formflaDened conduc ve low reluctance connectors and coils. Ribbons may be stacked for higher effect. The current transmits between the coils to produce currents in the opposing coils and induce intracranial currents. The orthogonally arranged coil pairs are used to target the magne cfluxes and induced currents to specific zones in the brain. Aflux concentrator is useful for concentra ng and focusing the magne c forces. High frequency switching and rela vely high powers for deeper penetra ons is me culously controlled using algorithms that incorporate frequency, distance and transmission mes such that the signals are construc ve rather than destruc ve at the target. Lengthy pulsa on streams are enabled by the low resistance in the energizing connec ons in the circuits. Preferably, cabling uses mul ple thin wire strands individually insulated and twisted or woven together in a Litz Wire format to distribute the electric current equally across the wire strands. This minimizes skin effect resistance and reduces heat genera on in the cabling. Pulsa on clusters of msec up to several seconds in length, e.g., 20msec to 20sec are alternated with rest periods where the cells’ interfaces recover. These limits can be surpassed under direc on of the AI directed algorithm, but preferably extremes in these and other parameters under control of the opera ng algorithm areflagged for operator aDen on and opportunity to override. Membrane receptors are internalized and / or recycled, TransmiDer chemicals are cleared. The releasing termini are resupplied with vesicles for the next round. The rest periods are adjusted to concentrate effects on the desired cell type, e.g., astrocytes, ependymal cells, and microglial cells. Microglial cells are rapidly fa gued, that is once ac vated return to the original state is more lengthy than that of neurons. Astrocytes tend to show a recovery me in between. Short rests concentrate on neuronal; ac vity. Microglial recovery can stretch to hours; and astrocyte excitement may be op mized by interpulse intervals of several minutes. For each individual and each therapy for each individual the pulse frequency, interpulsing dura ons and intersession ming should be confirmed with one or more of the imaging techniques. General acceptance of the subject to length of treatment sessions, me between treatments and ability to aDend the treatments should also be considered in therapy.

Claims

Claims 1. A transcranial s mula on device comprising: a magne cflux genera on circuit comprising at least two (one pair of) conduc ve coils; a data processor interface for supplying output to input to saidflux genera on circuit, an imaging tool that reports loca on of ac vity within the brain said input comprising instruc on to control ac va on of saidflux genera on circuit; said data processor comprising capacity to harbor at least one AI rou ne that incorporates loca on informa on of saidflux genera on circuit, report from said imaging tool, experiences from at least one subject reac ng to s mula on from said magne cflux genera on circuit; said AI rou ne instruc ng at least a por on of said transcranial s mula on device to generate at least one algorithm to process said output; an input to said data processor, said input configured for receipt of data associated with brain ac vity.

2. The transcranial s mula on device of claim 1 wherein said data associated with brain ac vity comprises data outpuDed by said imaging tool.

3. The transcranial s mula on device of claim 1 wherein said imaging tool comprises three dimensional EEG.

4. The transcranial s mula on device of claim 1 wherein said at least one pair of conduc ve coils are connected with Litz wire.

5. The transcranial s mula on device of claim 1 comprising at least a second pair of conduc ve coils.

6. The transcranial s mula on device of claim 5, wherein at least one member of at least one said pair of conduc ve coils is movable or retractable.

7. The transcranial s mula on device of claim 1 configured in a support in a head covering or cap format.

8. The transcranial s mula on device of claim 7, further comprising a track or arm that is interfaced with said at least one pair of conduc ve coils to move or retract said at least one pair of conduc ve coils.

9. The transcranial s mula on device of claim 1 further comprising a virtual reality (VR) s mulatory component, said VR component elici ng neuro ac vity in at least one zone of s mulatory interest.

10. A Repe ve Transcranial Magne c S mula on (rTMS) device comprising:a plurality of orthogonally arranged magne c circuits, said circuits each comprising a pair of electromagne c coils; a sensing apparatus to detect electrical ac vity, wherein said sensing apparatus is provided with screening hardware or soNware tofilter out or ignore outputs from said orthogonally arranged magne c circuits to provide data of signals emana ng from adjacent ssue electrical ac vity, wherein said data emana ng from adjacent ssue electrical ac vity comprises indica ons of strength, frequency and source of said signals; a processor that receives said data for incorpora on into a machine learning process to develop an Arficial Intelligence (AI) algorithm output, said AI algorithm output capable of adjus ng the ac va on of each of said plurality of orthogonally arranged magne c circuits to focus signal from each of said ac vated magne c circuits to concentrate on a targeted zone within a void between opposing poles of said magne c circuits.

11. The device of claim 10 comprising at least three orthogonally arranged magne c circuits.

12. The device of claim 10 wherein at least afirst of said plurality of orthogonally arranged magne c circuits is posi onally adjustable with respect to a second of said plurality of orthogonally arranged magne c circuits.

13. The device of claim 10 wherein electrical circuitry of said plurality of orthogonally arranged magne c circuits comprises Litz wire.

14. The device of claim 10 comprising a ferro ac ve projec on from a pole of at least one said orthogonally arranged magne c circuit, said projec on concentra ng magne sm effect from said pole.

15. The device of claim 10 further comprising aflux concentrator associated with at least one pole of said orthogonally arranged magne c circuits.

16. The device of claim 10 further comprising a hood encompassing said plurality of orthogonally arranged magne c circuits.

17. The device of claim 16 further wherein afirst pair of said plurality of orthogonally arranged magne c circuits is adjustable in space with respect to a second pair of said plurality of orthogonally arranged magne c circuits.

18. The device of claim 10 further comprising a second sensor, said second sensor capable of measuring magne cflux produced by at least one of said orthogonally arranged magne ccircuits, said second sensor interfaced with said AI algorithm capable of adjus ng the ac va on to control delivery of said magne cflux in accordance with algorithmic direc on.

19. The device of claim 10 further comprising a sound generates that feeds ultrasonic energy into said targeted zone.

20. A hyperbaric chamber comprising a device of claim 10.

21. A method for inducing modifica on in neurocircuitry, said method comprising: analyzing a subject brain to iden fy a zone or area of abnormal func on; introducing coordinates of said zone or area into said processor of claim 9; instruc ng said processor to create or access an AI algorithm specific to said subject brain; s mula ng said subject brain in accord with said algorithm; collec ng response data from said zone or area; adjus ng said algorithm based on said response data; and s mula ng said subject brain in accord with said adjusted algorithm.

22. The method of claim 21 wherein said analyzing comprises imaging brain func on using a method selected from the group consis ng of: MRI, PET, 3D-EEG, CT, PET-CT, and Doppler.

23. The method of claim 21 wherein said s mula ng comprises rapid switching between at least two of said plurality of said orthogonally arranged magne c circuits, said rapid switching comprising on-off cycling of said magne c circuits at a rate <20msec.

24. The method of claim 21 wherein said algorithm ac vated less than a totality of said plurality of orthogonally arranged magne c circuits.

25. The method of claim 21 wherein said s mula ng comprises rapid switching of said s mula ng between said plurality of orthogonally arranged magne c circuits on a me scale resul ng in a zone at the intersec on of the intracranial s mula ng from at least two of said plurality of orthogonally arranged magne c circuits receiving a signal post said rapid switching before a response at said zone to a signal prior to said rapid switching terminates.