Fusion proteins for purifying nucleic acids

Fusion proteins combining nucleic acid binding proteins and polypeptides with phase behavior provide an effective solution for purifying nucleic acids by forming separable complexes, addressing the challenges of size and impurity profile in existing methods.

WO2025043174A1PCT designated stage expired Publication Date: 2025-02-27DONALDSON CO INC
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Patent Information

Application Number
PCT/US2024/043621
Authority / Receiving Office
WO · WO
Patent Type
Applications
Current Assignee / Owner
Priority Date
2024-02-16
Filing Date
2024-08-23
Publication Date
2025-02-27

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Abstract

Provided herein are fusion proteins and methods of use thereof to purify nucleic acids from a composition. The disclosed compositions and methods allow for faster, more efficient purification of nucleic acids compared to traditional affinity chromatography.
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Citation Information

Patent Citations

  • Compositions and methods for the site-specific modification of polypeptides

    WO2015130846A2

  • Fusion proteins comprising a protein with phase behavior

    WO2022178537A1

Cited By

  • Purification matrices comprising AAV-binding polypeptides and methods of using the same

    US12637664B2

  • Protein-based purification matrices and methods of using the same

    US12692483B2