Biochemical analyzer

Abstract

The present invention relates to a biochemical analyzer. A base plate is further provided with a sampling pipette, and the sampling pipette has a swing arm which can be retracted for storage. During use, the sampling pipette extends to a sampling position, and returns to a storage position by means of a retraction structure, thereby reducing the overall height of the biochemical analyzer. A reagent tray is provided with a first drive motor, which drives the reagent tray to rotate, is coaxially arranged with the reagent tray, and is fixedly mounted on the base plate. A reaction tray is provided with a second drive motor, which drives a reaction cup holder on the reaction tray to rotate, is coaxially arranged with the reaction tray, and is fixedly mounted at the bottom of an incubation pan of the reaction tray. The reagent tray is configured to be a combined reagent tray on which reagent cells and sample cells are combined, such that during testing for a small number of items in public health examination, one reagent tray is used to achieve the testing placement of both the sample and the reagent. In addition, the reaction tray and the reagent tray are arranged in parallel, thereby reducing the overall structure of the biochemical analyzer to meet the requirement of mobile convenience for public health examination items.

Description

biochemical analyzer

[0001] This application claims priority to the above-mentioned Chinese patent application filed with the China Patent Office on August 28, 2023, with application number 202311091185.7 and invention name “Biochemical Analyzer”, the entire contents of which are incorporated by reference into the above-mentioned application. Technical Field

[0002] The present invention relates to the field of medical testing technology, and more particularly to a biochemical analyzer. Background Art

[0003] Fully automatic biochemical analyzers are often used in hospital laboratories, which include nearly 100 test items. To meet the requirements of a large number of test items, each test reagent corresponds to a different test item and needs to be tested on the fully automatic biochemical analyzer. Different test reagents are stored in different reagent compartments. Existing fully automatic biochemical analyzers use numbers to distinguish different reagent compartment positions. During actual operation, after the operator places a specific reagent into a specific reagent position on the reagent tray, it is necessary to set the parameters for the specific test item for that reagent position, including the added sample volume, reagent volume, detection wavelength, incubation time, reaction time, test type, etc.

[0004] However, due to the large number of test items and the relatively small number of reagent positions on the biochemical analyzer, each reagent position needs to frequently change the test items and temporarily re-set the parameters. Therefore, operating a fully automatic biochemical analyzer requires professional operators to set the parameters.

[0005] Free health checkups for the elderly, especially those in rural areas, involve 10 biochemical tests (12 in a few places). Public health health checkups are conducted regularly and centrally each year, requiring a large number of people to be tested and requiring in-depth visits to the grassroots level. Due to the lack of professionally trained operators at the grassroots level in rural areas, the parameters of biochemical analyzers are complex to set and the operation is cumbersome. Existing small biochemical analyzers suitable for transportation are semi-automatic or manual, which cannot meet the needs of large-scale health checkups. Fully automatic biochemical analyzers are large, heavy, and cumbersome to operate, making them inconvenient for large-scale health checkups in remote villages.

[0006] It should be pointed out here that the technical content provided in this section is intended to help those skilled in the art understand the present invention, and does not necessarily constitute prior art.

[0007] Summary of the Invention

[0008] In view of this, the purpose of the present invention is to provide a biochemical analyzer to meet the needs of public health examinations.

[0009] In order to achieve the above object, the present invention provides the following technical solutions:

[0010] A biochemical analyzer comprises a base plate, a reaction disk and a reagent disk arranged on the base plate along the length direction, a sampling needle is further provided on the base plate, and the sampling needle has a swing arm that can be retracted and stored;

[0011] The reagent disk has a first drive motor that is coaxially arranged to drive the reagent disk to rotate, and the first drive motor is fixed on the base plate;

[0012] The reaction tray has a coaxially arranged second drive motor for driving the reaction cup holder thereon to rotate. The second drive motor is fixedly mounted on the bottom of the incubator of the reaction tray.

[0013] Preferably, in the above-mentioned biochemical analyzer, the reagent disk comprises an inner ring reagent disk and an outer ring reagent disk arranged concentrically, and the inner ring reagent disk is divided into a plurality of evenly arranged sector-shaped areas;

[0014] The outer ring reagent disc includes a plurality of ear areas close to the sector area and evenly arranged around the outer circumference of the inner ring reagent disc;

[0015] The fan-shaped area is equipped with a first reagent box arranged in a conformal manner, and the ear area is equipped with a second reagent box arranged in a conformal manner;

[0016] It also includes a sample tube placement area that is arranged on the outer ring reagent disk and filled between adjacent ear areas.

[0017] Preferably, in the above-mentioned biochemical analyzer, the sector-shaped area is a triangular sector-shaped area having a triangular sector-shaped cross section, and a plurality of the triangular sector-shaped areas form an inner ring structure;

[0018] The inner circle of the ear area and the outer circle of the fan-shaped area share a common arc wall surface, and the ear area has a trapezoidal structure in which both the inner and outer wall surfaces are arc walls;

[0019] The first test kit is a fan-shaped test kit that matches the fan-shaped area, and the second test kit is a curved trapezoidal test kit that matches the ear area.

[0020] Preferably, in the above-mentioned biochemical analyzer, the reagent disc includes a reagent disc bottom plate, and the fan-shaped area and the ear area are surrounded by a thin-walled structure extending from the reagent disc bottom plate;

[0021] The inner side of the thin-wall structure is convexly provided with vertically arranged ribs.

[0022] Preferably, in the above-mentioned biochemical analyzer, the outer periphery of the reagent tray bottom plate is further arranged with an annular reagent tray outer wall plate, and the inner circle of the reagent tray outer wall plate encloses the inner cavity of the reagent tray;

[0023] The outer wall of the reagent disk extends downward to form a lower edge of the reagent disk with an annular structure, and the lower edge of the reagent disk is evenly distributed with a plurality of reagent disk slits running through the thickness direction thereof;

[0024] The substrate is further provided with a first photoelectric sensor that cooperates with the slit of the reagent disc to identify the rotation position of the reagent disc.

[0025] Preferably, in the above-mentioned biochemical analyzer, the reagent tray bottom plate, the fan-shaped area, the ear area and the reagent tray outer wall plate are integrally formed to form the reagent tray made of plastic material.

[0026] Preferably, in the above-mentioned biochemical analyzer, it further comprises a reagent disk housing fixedly mounted on the substrate, the reagent disk is rotatably arranged in the reagent disk housing, a photoelectric collection window is arranged on the outer ring of the reagent disk housing, and the first photoelectric sensor is installed in the photoelectric collection window;

[0027] The first photoelectric sensor has a photoelectric collection portion that cooperates with the lower edge of the reagent disk.

[0028] Preferably, in the above-mentioned biochemical analyzer, the reaction disk comprises an incubation pot fixedly mounted on the base plate, a bracket support seat is coaxially arranged inside the incubation pot, and a cuvette bracket with a disc-shaped structure is arranged on the bracket support seat;

[0029] A second drive motor is coaxially arranged at the bottom of the incubation pot, and a bracket transmission shaft connecting the second drive motor and the reaction cup bracket is arranged in the bracket support seat.

[0030] Preferably, in the above biochemical analyzer, the outer ring of the incubation pot is provided with an annular incubation track;

[0031] A plurality of reaction cup placement holes are evenly distributed on the annular outer ring of the reaction cup bracket, and the reaction cup placement holes and the incubation track are used to incubate the reaction cup.

[0032] Preferably, in the above biochemical analyzer, the middle portion of the reaction cup holder is a rotation driving portion placed on the holder support seat, the rotation driving portion has a plurality of extension portions spaced apart in the radial direction, and the extension ends of the extension portions are connected to the annular outer ring.

[0033] Preferably, in the above-mentioned biochemical analyzer, the inner ring of the reaction cup holder has a holder lower edge portion extending axially, and a plurality of holder slits are spaced apart at the extending end of the holder lower edge portion;

[0034] A second photoelectric sensor is fixedly installed in the incubation pot and matches the slit of the bracket.

[0035] Preferably, in the above-mentioned biochemical analyzer, an inwardly concave mounting groove is provided on the outer periphery of the incubation pot, and an insulating outer layer is fixedly installed on the outer periphery of the incubation pot. Insulating protrusions are arranged on the inner circle of the insulating outer layer, and the insulating outer layer is pressed tightly into the mounting groove by the insulating protrusions.

[0036] The biochemical analyzer provided by the present invention includes a base plate, a reaction tray and a reagent tray arranged on the base plate along the length direction. The base plate is also provided with a sampling needle, and the sampling needle has a swing arm that can be retracted for storage. When in use, the sampling needle extends to a sampling position and returns to a storage position through a retracting structure, thereby reducing the overall height of the biochemical analyzer. The reagent tray has a first drive motor that is coaxially arranged to drive its rotation, and the first drive motor is fixed to the base plate; the reaction tray has a second drive motor that is coaxially arranged to drive the reaction cup holder on it to rotate, and the second drive motor is fixed to the bottom of the incubator of the reaction tray; the reagent tray is a combined reagent tray with a combined reagent position and a sample position arranged in the inner cavity.

[0037] The reagent tray is set as a combined reagent tray that combines reagent positions and sample positions. When used for small-quantity testing in public health examinations, the test positions of samples and reagents can be simultaneously realized through one reagent tray, and the reaction tray and reagent tray are arranged in parallel, which reduces the overall structure of the biochemical analyzer and meets the needs of mobile convenience for public health examination projects. BRIEF DESCRIPTION OF THE DRAWINGS

[0038] The above and other objects, features and advantages of the present invention will become more apparent through the following description of the embodiments of the present invention with reference to the accompanying drawings, in which:

[0039] FIG1 is a schematic diagram of the structural arrangement of a biochemical analyzer provided by the present invention;

[0040] FIG2 is a front view of the structure of the reagent disk in the biochemical analyzer provided by the present invention;

[0041] FIG3 is a schematic diagram of the driving structure of the reagent disk in FIG2 ;

[0042] FIG4 is a schematic diagram of the code disk structure of the reagent disk in FIG2 ;

[0043] FIG5 is a schematic diagram of the structure of the reagent disk housing arranged on the periphery of the reagent disk;

[0044] FIG6 is a schematic diagram of the photoelectric sensor arrangement structure of the reagent disk in FIG2 ;

[0045] FIG7 is a cross-sectional view of the installation structure of the reaction disk in the biochemical analyzer provided by the present invention;

[0046] FIG8 is a schematic structural diagram of the incubation pot of the reaction tray in FIG7 ;

[0047] FIG9 is an exploded view of the driving structure of the reaction disk in FIG7 ;

[0048] FIG10 is a schematic diagram of the front structure of the reaction disk in FIG7;

[0049] FIG11 is a schematic structural diagram of the back side of the reaction disk in FIG7 . DETAILED DESCRIPTION

[0050] The present invention will be described below based on examples, but the present invention is not limited to these examples.

[0051] Public health physical examination items generally include 10 or 12 items. The biochemical items are relatively clear and the number is small. In the use of reagents, 8 items including alanine aminotransferase (ALT), aspartate aminotransferase (AST), low-density lipoprotein cholesterol (LDL), high-density lipoprotein cholesterol (HDL), urea nitrogen (UREA), creatinine (CRE), total bilirubin (TBIL) and direct bilirubin (DBIL) are double-reagent items; glucose (GLU), triglycerides (TG), albumin (ALB) and total cholesterol (THCO4) are single-reagent items.

[0052] Double-reagent detection projects require two reagents to jointly undergo a biochemical reaction with the blood sample (specimen), and the content of the detected substance is calculated based on the optical changes of the reaction system. To avoid the working solution from being unable to guarantee long-term effectiveness after pre-mixing, the two reagents are only temporarily mixed together during the reaction. Single-reagent detection projects only require one reagent to undergo a biochemical reaction with the blood sample (specimen), and the content of the detected substance is calculated based on the optical changes of the reaction system. In biochemical analysis instruments, a single reagent is usually defined as only the R1 reagent, that is, when the sample is added to the R1 reagent, the reaction starts immediately; a double reagent is defined as two reagents, R1 and R2. The sample is first added to the reagent R1 to participate in the reaction, and then the reagent R2 is added after incubation for further reaction to achieve the detection purpose. Usually, R1 reacts with the sample to remove interference or prepare for further reaction after the addition of R2.

[0053] As shown in FIG1 , FIG1 is a schematic diagram of the structural arrangement of the biochemical analyzer provided by the present invention.

[0054] The biochemical analyzer provided in this application is used in public health physical examination projects and can simultaneously perform dual-reagent detection projects and single-reagent detection projects.

[0055] The biochemical analyzer comprises a base plate 1, a reaction tray 2 and a reagent tray 3 arranged lengthwise on the base plate 1. The base plate 1 is also provided with a sampling needle 4 having a retractable swing arm. The reagent tray 3 has a first drive motor 31 coaxially arranged thereon for driving its rotation. The first drive motor 31 is fixedly mounted on the base plate 1. The reaction tray 2 has a second drive motor 22 coaxially arranged thereon for driving the rotation of a reaction cup holder 21 thereon. The second drive motor 22 is fixedly mounted on the bottom of an incubator 23 of the reaction tray 2. The reagent tray 3 is a combined reagent tray with both reagent and sample positions arranged in its inner cavity.

[0056] The biochemical analyzer includes a base plate 1, a reaction disk 2 and a reagent disk 3 arranged on the base plate 1. The reagent disk 3 is a combined reagent disk for storing reagents and samples at the same time. A plurality of cuvettes are arranged in the reaction disk 2. The cuvettes also serve as reaction cups for receiving reagents and samples injected from the reagent disk 3.

[0057] A plurality of reagent compartments are arranged in the reagent tray 3. In order to meet the needs of public health examination items, the reagent compartments are configured to combine reagent positions and sample positions.

[0058] As shown in Figures 2 to 6, Figure 2 is a front view of the structure of the reagent tray in the biochemical analyzer provided by the present invention; Figure 3 is a schematic diagram of the drive structure of the reagent tray in Figure 2; Figure 4 is a schematic diagram of the code disk structure of the reagent tray in Figure 2; Figure 5 is a schematic diagram of the reagent tray shell structure arranged on the periphery of the reagent tray; Figure 6 is a schematic diagram of the photoelectric sensor arrangement structure of the reagent tray in Figure 2.

[0059] In the present application, the reagent disk 3 comprises an inner ring reagent disk and an outer ring reagent disk arranged concentrically, and the inner ring reagent disk is divided into a plurality of evenly arranged sector-shaped areas 32;

[0060] The outer reagent disc includes a plurality of ear regions 33 adjacent to the sector region 32 and evenly arranged around the circumference of the inner reagent disc;

[0061] It also includes a sample tube placement area 34 arranged on the outer ring of the outer ring reagent disk and in front of the adjacent ear area 33.

[0062] In this embodiment, the sector area 32 is a triangular sector area having a triangular sector cross section, and a plurality of triangular sector areas form an inner ring structure;

[0063] The inner circle of the ear region 33 and the outer circle of the sector region 32 share a common arc wall surface, and the ear region 33 has a trapezoidal structure in which both the inner and outer wall surfaces are arc wall surfaces;

[0064] It also includes a fan-shaped reagent kit 301 that matches the fan-shaped area 32 and a curved trapezoidal reagent kit 302 that matches the ear area 33.

[0065] Specifically, according to the usage of sample detection, during a sampling inspection process, it is necessary to carry out the inspection of different biochemical projects for each sample, the reagent disc 3 is provided with an inner ring and an outer ring structure with a concentric arrangement, the inner ring reagent disc is divided into a plurality of evenly arranged fan-shaped areas 32, and each fan-shaped area 32 is set to the first reagent position for placing different detection reagents. Preferably, the fan-shaped area 32 is designed as a triangular fan-shaped area with a triangular fan-shaped cross section, so that a plurality of triangular fan-shaped areas are surrounded by an inner ring structure. When the inner ring reagent disc is 10 or 12 items according to the inspection items, it is preferably arranged as 10 fan-shaped areas or 12 fan-shaped areas to meet the arrangement requirements of 10 or 12 reaction reagents in the public health physical examination items. The inner ring reagent disc is used to store the R1 reagent of the double reagent detection item or the R1 reagent of the single reagent detection item.

[0066] At the same time, since public health testing involves both dual-reagent and single-reagent tests, to facilitate the distinction between different reagents, the outer reagent disc is configured with multiple evenly spaced ear regions 33. The inner side of the ear region 33 has an inner diameter comparable to the outer circumference of the inner reagent disc, and the outer side of the ear region 33 also adopts a curved surface structure. Preferably, the ear region 33 is designed with the inner and outer wall surfaces being circular arc wall surfaces, and the inner and outer wall surfaces are connected by a radially extending side wall surface to form a curved trapezoidal structure.

[0067] To ensure rotational balance of the reagent tray, the outer reagent tray has eight ear regions 33, each consisting of two adjacent ear regions. These four groups of ear regions 33 are evenly distributed around the outer ring of the inner reagent tray. The ear regions 33 of the outer reagent tray are used to hold the R2 reagent for dual-reagent tests. By designating the inner and outer reagent trays with sector-shaped regions 32 and ear regions 33, respectively, the R1 and R2 reagents can be distinguished, improving the accuracy of reagent container identification.

[0068] A sample placement area 34 (sample rack not shown) is reserved between the ear areas 33 and the outer ring of the reagent tray 3. Specifically, the sample placement area 34 is used to place blood collection tubes. Blood collection tubes occupy a small space and adapt to the cylindrical structure. Combined with the outer ring reagent tray and the outer periphery of the reagent tray, the sample tubes and test reagents can be arranged in a combined manner while minimizing the size of the reagent tray, thereby fully utilizing the space.

[0069] In the present application, the reagent disc 3 includes a reagent disc bottom plate 35 , and the sector area 32 and the ear area 33 are surrounded by a thin-walled structure extending from the reagent disc bottom plate 35 ;

[0070] Vertically arranged ribs 37 are protruded from the inner side of the thin-walled structure.

[0071] The outer periphery of the reagent tray bottom plate 35 is further provided with an annular reagent tray outer wall plate 38 , and the inner circle of the reagent tray outer wall plate 38 forms the inner cavity of the reagent tray;

[0072] The outer wall plate 38 of the reagent disk extends downward to form a lower edge portion 39 of the reagent disk with an annular structure. The lower edge portion 39 of the reagent disk is evenly distributed with a plurality of reagent disk slits running through the thickness direction thereof.

[0073] The substrate 1 is further provided with a first photoelectric sensor 5 that cooperates with the slit of the reagent disk and identifies the rotation position of the reagent disk 3 .

[0074] Preferably, the reagent disk slits include a reagent disk zero slit 391 and a reagent disk counting slit 392 , a first reagent disk spacing d1 is provided between the reagent disk zero slit 391 and the reagent disk counting slit 392 , a second reagent disk spacing d2 is provided between adjacent reagent disk counting slits 392 , and the first reagent disk spacing d1 is different from the second reagent disk spacing d2.

[0075] The reagent tray 3 includes a reagent tray base 35, and the fan-shaped area 32 and the ear area 33 are surrounded by a thin-walled structure extending from the reagent tray base 35. The inner wall surfaces of the fan-shaped area 32 and the ear area 33 are provided with a plurality of vertically distributed ribs 37 for positioning and fixing the reagent reagents arranged therein.

[0076] An annular reagent tray outer wall plate 38 is further arranged on the periphery of the reagent tray bottom plate 35 . The reagent tray outer wall plate 38 encloses the inner cavity of the reagent tray and is used to protect the reagent kit and samples placed therein.

[0077] When the biochemical analyzer is sampling reagents and samples, the reagent position or sample position is adjusted by rotating the reagent disc 3, and the reagent or sample is sucked by the sampling needle 4. When the existing reagent disc is rotated and positioned, the position of the reagent disc is identified by providing a code disc on the outer periphery of the reagent disc and a zero position sensor on the inner side of the reagent disc. In order to reduce the space occupied by the outer periphery of the reagent disc due to the arrangement of the code disc, the present application extends the reagent disc outer wall plate 38 downward to form a reagent disc lower edge portion 39 with an annular structure. The reagent disc lower edge portion has a thin-walled structure. At the same time, a plurality of reagent disc slits are evenly distributed on the reagent disc lower edge portion and extend through the thickness direction of the reagent disc.

[0078] A first photoelectric sensor 5 is also disposed and fixed to the substrate 1. The first photoelectric sensor 5 cooperates with the reagent disk slits to identify the rotational position of the reagent disk 3. Specifically, the reagent disk slits include a reagent disk zero position slit 391 and a reagent disk counting slit 392. A first reagent disk spacing d1 is defined between the reagent disk zero position slit 391 and the reagent disk counting slit 392, which is different from a second reagent disk spacing d2 between adjacent reagent disk counting slits 392.

[0079] Preferably, the reagent disk zero position slit 391 is set as the zero position of the reagent disk 3. Three reagent disk zero position slits 391 are provided, with the first reagent disk spacing d1 between adjacent ones. Multiple reagent disk counting slits 392 are provided, evenly spaced along the outer periphery of the reagent disk bottom edge 39. Two adjacent reagent disk counting slits 392 are used to measure the rotation angle of the reagent disk 3. The reagent disk zero position slit 391 and the reagent disk counting slit 392 are used to identify the starting position of the reagent disk 3 and the rotation angle of the reagent disk 3 during the sampling process, thereby achieving accurate measurement of the rotation angle of the reagent disk 3.

[0080] Of course, the first drive motor 31 provided in this application adopts a stepper motor, and the reagent disk slit can be set only on the lower edge 39 of the reagent disk. The first photoelectric sensor 5 cooperates with the reagent disk slit to identify the zero position of the reagent disk 3, and utilizes the coaxial drive structure of the stepper motor and the reagent disk 3. When the first drive motor 31 adopts a stepper motor, the rotation angle of the stepper motor and the position of the fan-shaped reagent kit, the arc trapezoidal reagent kit and the sample tube placement area on the reagent disk are identified, and together with the zero position reagent disk slit of the reagent disk 3, the rotation angle of the reagent disk 3 is recognized and adjusted.

[0081] In the present application, the reagent disc housing 303 is further included, which is fixedly mounted on the substrate 1. The reagent disc 3 is rotatably arranged in the reagent disc housing 303. A photoelectric collection window 306 is arranged on the outer ring of the reagent disc housing 303. The first photoelectric sensor 5 is installed in the photoelectric collection window 306.

[0082] The first photoelectric sensor 5 has a U-shaped photoelectric collection portion that cooperates with the lower edge 39 of the reagent disk.

[0083] Furthermore, a photoelectric sensor support column 51 extends from the substrate 1, and the first photoelectric sensor 5 adopts a U-shaped photoelectric position sensor. The reagent disk slit falls on the groove portion of the U-shaped photoelectric position sensor, and its transmitter and receiver are respectively located on both sides of the U-shaped groove, and form an optical axis. When the reagent disk slit passes through the U-shaped groove, the optical axis is blocked when the reagent disk lower edge 39 passes through the U-shaped groove. When the reagent disk slit on the reagent disk lower edge 39 passes through the U-shaped groove to connect to the optical axis, counting and position recognition are realized. The photoelectric switch is used to generate a switch signal for detecting the rotation position of the reagent disk, thereby identifying the rotation angle of the reagent disk 3.

[0084] Test kit and sample tube are placed in the reagent tray 3. The test kit comprises a fan-shaped test kit 301 arranged in the fan-shaped area 32, and a circular arc trapezoidal test kit 302 arranged in the ear area 33. The test kits of two structures are used to store R1 and R2 reagents respectively. By rotating the reagent tray 3, its sampling position is adjusted. In order to ensure the safety of the reagent tray 3 in the detection process, a reagent tray shell 303 is also fixedly installed on the substrate 1. The reagent tray shell 303 has an inner cavity 304 of a tubular structure, and the reagent tray 3 is arranged in the inner cavity 304 of the reagent tray shell 303. Preferably, the reagent tray shell 303 is a hard metal shell with a thin-walled structure, and the top opening of the reagent tray shell 303 is provided with a flange 305 to improve structural strength. The bottom wall edge of the reagent tray shell 303 is provided with a photoelectric acquisition window 306. The first photoelectric sensor 5 extends into the photoelectric acquisition window 306 and cooperates with the reagent tray lower edge 39 to detect the rotation position of the reagent tray 3.

[0085] In the existing reagent tray driving structure, a driving motor is arranged at the bottom of the reagent tray, and power is output through a pulley, which is connected to a transmission shaft extending from the reagent tray for power transmission.

[0086] The reagent tray 3 provided herein reduces its overall size by integrating the reagent kit and sample tubes into the tray. To reduce the complexity of the drive mechanism for the rotation of the tray 3, the drive shaft and belt drive structure extending from the tray are eliminated. A first drive motor 31 capable of variable frequency rotation is fixed to the base plate 1, and its drive shaft is directly connected to the bottom of the tray 3.

[0087] Further, in the middle part of reagent disc 3, drive connection seat 307 is set, drive connection seat 307 is set, axial hole is set, the drive shaft of the first drive motor 31 is fixed in the axial hole. Directly drive reagent disc 3 by the first drive motor 31 and rotate, reduced the rotation drive structure of reagent disc 3, optimized drive structure, reduced the volume of drive structure.For ensuring the structural stability of reagent disc 3 long-time rotation work. Distribute many reagent disc reinforcement plates 36 that stretch out radially along it on the bottom surface of reagent disc 3, the thickness direction of reagent disc reinforcement plates 36 is along the circumferential arrangement of drive connection seat 307, and length direction stretches out radially, reagent disc reinforcement plates 36 is affixed to the bottom wall surface of reagent disc 3 in height direction, the first drive motor 31 output power, transmit power by drive connection seat 307, and by many reagent disc reinforcement plates 36, drive reagent disc 3 to rotate on the whole, the turning moment that the first drive motor 31 is transmitted is dispersed to the whole bottom wall surface of reagent disc 3, avoid stress concentration, ensure the transmission structure stability of reagent disc 3 long-time work.

[0088] As shown in Figures 7 to 11, Figure 7 is a cross-sectional view of the installation structure of the reaction disk in the biochemical analyzer provided by the present invention; Figure 8 is a schematic diagram of the incubator structure of the reaction disk in Figure 7; Figure 9 is an exploded view of the drive structure of the reaction disk in Figure 7; Figure 10 is a schematic diagram of the front structure of the reaction disk in Figure 7; and Figure 11 is a schematic diagram of the back structure of the reaction disk in Figure 7.

[0089] In the present application, the reaction tray 2 includes an incubation pot 21 fixed on the base plate 1, a bracket support seat 211 is coaxially arranged inside the incubation pot 21, and a reaction cup bracket 23 with a disc-shaped structure is arranged on the bracket support seat 211;

[0090] A second drive motor 24 is coaxially arranged at the bottom of the incubation pot 21 , and a bracket transmission shaft 241 connecting the second drive motor 24 and the cuvette bracket 23 is arranged in the bracket support seat 211 .

[0091] The outer ring of the incubation pot 21 is provided with an annular incubation track 22;

[0092] A plurality of cuvette placement holes 232 are evenly distributed on the annular outer ring 231 of the cuvette holder 23 . The cuvette placement holes 232 and the incubation track 22 incubate the cuvette.

[0093] The biochemical analyzer provided in the present application also has a reaction tray 2 arranged in parallel with the reagent tray 3. The reaction tray 2 includes an incubation pot 21 fixedly mounted on the base 1. A ring-shaped incubation track 22 is arranged in the incubation pot 21. The reaction tray 2 also has a reaction cup holder 23. The annular outer ring 231 of the reaction cup holder 23 is provided with multiple reaction cup placement holes 232. A reaction cup holder is arranged in each reaction cup placement hole 232. After the reaction cups are placed one by one in the reaction cup placement holes 232, the bottom of the reaction cup falls on the incubation track 22. By rotating the reaction cup holder 23, the reaction cups on the reaction cup holder 23 are continuously incubated and switched to different workstations.

[0094] In this embodiment, the middle portion of the cuvette holder 23 is a rotation driving portion that rests on the holder support seat 211. The rotation driving portion is a disc-shaped holder mounting plate 233 having a plurality of extensions 234 distributed radially at intervals. The extension ends of the extensions 234 are connected to an annular outer ring 231.

[0095] A bracket lower edge portion 237 extends axially from the inner ring of the cuvette bracket 23, and a plurality of bracket slits are spaced apart at the extended end of the bracket lower edge portion 237.

[0096] A second photoelectric sensor 25 is fixedly mounted in the incubation pot 21 and matches the slit of the bracket.

[0097] The center of the cuvette holder 23 is a holder mounting plate 233, which transmits the rotational drive force. A holder support 211 is coaxially arranged within the incubation vessel 21, supporting the cuvette holder 23 and transmitting its rotational drive force. Specifically, a second drive motor 24 is disposed at the bottom of the incubation vessel 21. The drive shaft of the second drive motor 24 extends into the holder support 211. A holder transmission shaft 241 is disposed within the holder support 211. This shaft includes a first connection end connected to the drive shaft of the second drive motor 24 and a second connection end connected to the center of the cuvette holder 23.

[0098] A rotating bearing 242 is also disposed within the bracket support seat 211, and the bracket transmission shaft 242 is axially pressed against the rotating bearing 242. A bearing step 212 supporting the rotating bearing 242 is disposed within the bracket support seat 211, with the outer ring of the rotating bearing 242 supported on the bearing step 212, and the inner ring of the rotating bearing 242 is mounted on the bracket transmission shaft 241.

[0099] The second connection end of the bracket transmission shaft 241 connected to the reaction cup bracket 23 is a flange structure. Correspondingly, the middle part of the reaction cup bracket 23 is provided with rotational driving power through the disc-shaped bracket mounting plate 233, and the reaction cup bracket 23 is fixed to the second connection end of the bracket transmission shaft 241 through the bracket mounting plate 233.

[0100] The cuvette holder 23 is driven by a holder mounting plate 233 connected to a holder drive shaft 241. The annular outer ring 231 is provided with multiple cuvette placement holes 232 for receiving cuvettes. Multiple radially extending extensions 234 are spaced apart between the holder mounting plate 233 and the annular outer ring 231. The holder mounting plate 233, the extensions 234, and the annular outer ring 231 form the rotational support structure of the cuvette holder 34, ensuring the stability of the rotational structure.

[0101] Furthermore, the extension portion 234 includes five strips evenly connected between the bracket mounting plate 233 and the annular outer ring 231, and the inner side of each extension portion also extends vertically and connects the bracket reinforcement rib 235 between the bracket mounting plate 233 and the annular outer ring 234, thereby further improving the stability of power transmission during rotation.

[0102] When the reaction tray 2 performs rotation detection on cuvettes, it is necessary to identify the position of each cuvette. A lower bracket portion 236 extends axially from the inner ring of the cuvette holder 23. The lower bracket portion 236 is integrally connected to the annular outer ring 231. Multiple bracket slits 237 are spaced apart at the protruding end of the lower bracket portion 236. Specifically, the bracket slits 237 include a zero-position slit and a counting slit. A first bracket spacing between the zero-position slit and the counting slit is different from a second bracket spacing between adjacent counting slits. This allows the zero position of the cuvette holder to be recorded during rotation, as well as the positions of different cuvettes based on the zero position. Preferably, the lower bracket portion is located on the inner side of the annular outer ring.

[0103] Adapting to the arrangement of the bracket lower edge 237, a second photoelectric sensor 25 is fixedly mounted within the incubation pot 21. The reaction tray 2, adapted to the cuvettes on the outer ring of the cuvette holder 23, cooperates with the incubation track 22 on the outer ring of the incubation pot 21 to incubate the samples within the cuvettes. After the inner ring of the incubation pot 21 accommodates the space for the bracket support seat 211, a large residual cavity remains. The bracket lower edge 237 is positioned inside the annular outer ring 231, and a second photoelectric sensor mounting seat is positioned within the residual cavity. The second photoelectric sensor 25 is a split-type photoelectric sensor, with its transmitting and receiving ends located on either side of the bracket lower edge 237. The cable for the second photoelectric sensor 25 is led out from the bottom of the incubation pot 21.

[0104] By utilizing the internal residual cavity of the incubation pot 21 to monitor the position of the reaction cup holder 23, there is no need to set an independent code disk on the periphery of the incubation pot 21 to monitor the position of the reaction cup holder 23, thereby reducing the monitoring components on the periphery of the incubation pot 21, further reducing the space occupied by the incubation pot, and further reducing the space occupied by the biochemical analyzer.

[0105] Of course, relying on the coaxial drive structure of the second drive motor 22 and the reaction disk 2, the bracket slit 237 can be set as only one on the lower edge 236 of the bracket, or set on a protrusion on the bracket 23 that cooperates with the second photoelectric sensor 25, through the identification structure of the second photoelectric sensor 25 and the lower edge 237 of the bracket below the bracket 3, such as when there is a lower edge 236 of the bracket, a single bracket slit 237 is set to cooperate with the second photoelectric sensor 25 to perform zero position recognition, and the second drive motor 22 adopts a stepping motor, and the rotation position and rotation angle of the reaction disk 2 are identified by the rotation angle of the stepping motor; or the protrusion on the bracket 23 and the second photoelectric sensor 25 are set to perform zero position recognition by blocking, and when not blocked, they cooperate with the second drive motor 22 to perform position recognition of the reaction disk 2.

[0106] In this embodiment, an inwardly concave mounting groove 213 is provided on the outer periphery of the incubation pot 21, and an insulating outer layer 26 is also fixedly installed on the outer periphery of the incubation pot 21. The inner circle of the insulating outer layer 26 is arranged with insulating protrusions, and the insulating outer layer 26 is pressed tightly into the mounting groove 23 by the insulating protrusions.

[0107] An incubation track 22 is provided within the incubation pot 21, which is filled with incubation liquid and uses a water bath to maintain the temperature of the reaction cups. A concave mounting groove 213 is provided on the outer periphery of the incubation pot 21. An insulating outer layer 26 is also fixed to the outer periphery of the incubation pot 21. The inner ring of the insulating outer layer 26 is provided with insulating protrusions, which are pressed tightly into the mounting groove 213. This not only helps to locate the insulating outer layer and the incubation pot 21 in the installation position, but also increases the insulation thickness of the insulating outer layer, thereby improving the heat preservation capacity of the incubation pot.

[0108] Furthermore, the insulating outer layer 26 comprises multiple segments arranged at intervals around the periphery of the incubator. By configuring the insulating outer layer 26 and the incubator 21 as a segmented assembly structure, space is reserved for installing water inlet channels, drainage channels, and thermal protection structures on the incubator 21, thereby improving the convenience of the incubator installation structure.

[0109] The outer ring of the incubator 21 is also provided with multiple mounting ears 27. Multiple support posts extend from the base plate 1. The extended positions of the support posts correspond to the positions of the mounting ears 27 on the incubator. The support posts connect the mounting ears 27, supporting the incubator 21 above the base plate 1. Space for the second drive motor 24 is reserved between the incubator 21 and the base plate 1. Furthermore, after the incubator 21 is raised by the support posts, it is maintained at the same height as the reagent tray 3, facilitating the sampling needle to extract samples from the reagent tray and add them to the reaction cup.

[0110] The reagent tray 3 and reaction tray 2 are positioned adjacent to each other. Two sampling needles 4 are positioned between the two trays, one near each end along the substrate's width. The sampling needles 4 include a drive mechanism, a sampling arm positioned at the drive end of the drive mechanism, and a sample loading needle extending from the sampling arm. With the two sampling needles positioned at opposite ends of the substrate's width, they perform a cross-sampling and loading process, extracting reagents or samples from the reagent tray and loading them into the reaction cup, improving loading efficiency.

[0111] Two rinsing cups 5 are also arranged between the reagent disk 3 and the reaction disk 2. The two rinsing cups 5 are arranged in parallel and correspond to the positions of the two sampling needles 4 respectively. They are used to rinse the sample needles on the sampling needles 4 after the sampling needles 4 take samples, so as to facilitate the retention of liquid in the sample needles between two adjacent samples.

[0112] The sampling needle 4 is a retractable needle capable of lifting and rotating. When extracting liquid between the reagent tray 3 and the reaction tray 2, the swing arm of the sampling needle 4 is higher than both trays. Therefore, when the top cover of the biochemical analyzer is closed, the highest point of the sampling needle limits the overall height of the instrument. By designing the sampling needle to be retractable, the overall height of the instrument is reduced, further minimizing the overall size of the analyzer during transport and improving its ease of transport.

[0113] Furthermore, the sampling needle 4 includes a sampling needle seat. A first motor mounting plate is provided on the first side of the sampling needle seat, on which a rotating motor is arranged. A rotating pulley is provided on the second side of the sampling needle seat. The output shaft of the rotating motor is connected to the rotating pulley via a transmission belt, driving the sampling needle to swing to switch the position between the reaction disk and the reagent disk. A push rod is coaxially arranged on the rotating pulley, and the end of the push rod is connected to a swing arm, and the push rod can move up and down along the axis. When the sampling needle is working, the push rod moves the sampling needle to the working height and drives the sampling needle to move up and down during the cleaning process; when the sampling needle completes the liquid extraction work and the biochemical analyzer is folded up and transferred, the sampling needle is automatically retracted, and the sampling needle tip of the sampling needle is recovered into the rinse cup, thereby achieving a reduction in the height of the biochemical analyzer when it is folded up.

[0114] The base 1 is also provided with a flushing needle assembly 6 and a stirring assembly 7 for cleaning the reaction cups on the reaction disk 2 and stirring after adding reagents and samples.

[0115] The foregoing description is merely a preferred embodiment of the present invention and is not intended to limit the present invention. Those skilled in the art will readily appreciate that various modifications and variations of the present invention are possible. Any modifications, equivalent substitutions, or improvements made within the spirit and principles of the present invention are intended to be within the scope of protection of the present invention.

Claims

1. A biochemical analyzer, characterized in that: It comprises a base plate, a reaction plate and a reagent plate arranged on the base plate along the length direction, and a sampling needle is also arranged on the base plate, and the sampling needle has a swing arm that can be retracted and stored; The reagent disk has a first drive motor which is coaxially arranged and drives the reagent disk to rotate, and the first drive motor is fixedly mounted on the substrate; The reaction tray has a coaxially arranged second driving motor for driving the reaction cup bracket thereon to rotate, and the second driving motor is fixedly mounted on the bottom of the incubator of the reaction tray.

2. The biochemical analyzer according to claim 1, characterized in that: The reagent disk comprises an inner ring reagent disk and an outer ring reagent disk which are arranged concentrically, and the inner ring reagent disk is divided into a plurality of evenly arranged sector-shaped areas; The outer ring reagent disk includes a plurality of ear regions close to the sector-shaped region and evenly arranged around the outer circumference of the inner ring reagent disk; The fan-shaped area has a first reagent kit arranged in a random manner, and the ear area has a second reagent kit arranged in a random manner; It also includes a sample tube placement area which is arranged on the outer ring reagent disk and filled between adjacent ear areas.

3. The biochemical analyzer according to claim 2, characterized in that: The fan-shaped area is a triangular fan-shaped area with a triangular fan-shaped cross section, and a plurality of the triangular fan-shaped areas form an inner ring structure; The inner circle of the ear region and the outer circle of the fan-shaped region share a common arc wall surface, and the ear region has an arc-surface trapezoidal structure in which both the inner wall surface and the outer wall surface are arc wall surfaces; The first test kit is a fan-shaped test kit that matches the fan-shaped area, and the second test kit is a curved trapezoidal test kit that matches the ear area.

4. The biochemical analyzer according to claim 3, characterized in that: The reagent tray comprises a reagent tray bottom plate, and the fan-shaped area and the ear area are surrounded by a thin-walled structure extending from the reagent tray bottom plate; The inner side of the thin-wall structure is convexly provided with vertically arranged ribs.

5. The biochemical analyzer according to claim 4, characterized in that: The outer periphery of the reagent tray bottom plate is also provided with an annular reagent tray outer wall plate, and the inner circle of the reagent tray outer wall plate forms an inner cavity of the reagent tray; The outer wall plate of the reagent disk extends downwardly to form a lower edge of the reagent disk with an annular structure, and the lower edge of the reagent disk is evenly distributed with a plurality of reagent disk slits that penetrate the thickness direction thereof; The substrate is also provided with a first photoelectric sensor which cooperates with the slit of the reagent disk and identifies the rotation position of the reagent disk.

6. The biochemical analyzer according to claim 5, characterized in that: The reagent tray bottom plate, the fan-shaped area, the ear area and the outer wall plate of the reagent tray are made of plastic material and are integrally formed.

7. The biochemical analyzer according to claim 6, characterized in that: It also includes a reagent disk housing fixedly mounted on the substrate, the reagent disk is rotatably arranged in the reagent disk housing, a photoelectric collection window is arranged on the outer ring of the reagent disk housing, and the first photoelectric sensor is installed in the photoelectric collection window; The first photoelectric sensor has a photoelectric collection portion that cooperates with the lower edge of the reagent disk.

8. The biochemical analyzer according to claim 1, characterized in that: The reaction tray comprises an incubation pot fixedly mounted on the base plate, a bracket support seat is coaxially arranged inside the incubation pot, and a reaction cup bracket with a disc-shaped structure is arranged on the bracket support seat; A second drive motor is coaxially arranged at the bottom of the incubation pot, and a bracket transmission shaft connecting the second drive motor and the reaction cup bracket is arranged in the bracket support seat.

9. The biochemical analyzer according to claim 8, characterized in that: The outer ring of the incubation pot is provided with an annularly arranged incubation track; The annular outer ring of the reaction cup bracket is evenly distributed with a plurality of reaction cup placement holes, and the reaction cup placement holes and the incubation track are used to incubate the reaction cup.

10. The biochemical analyzer according to claim 9, characterized in that: The middle part of the reaction cup bracket is a rotation driving part falling on the bracket support seat, and the rotation driving part has a plurality of extension parts distributed at intervals along the radial direction, and the extension ends of the extension parts are connected to the annular outer ring.

11. The biochemical analyzer according to claim 10, characterized in that: The inner ring of the reaction cup bracket is provided with a bracket lower edge portion extending axially, and a plurality of bracket slits are spaced apart at the extending end of the bracket lower edge portion; The incubator is provided with a second photoelectric sensor which matches with the slit of the bracket.

12. The biochemical analyzer according to claim 11, characterized in that: The outer circumference of the incubation pot is provided with an inwardly concave mounting groove, the outer circumference of the incubation pot is also fixed with an insulating outer layer, the inner circle of the insulating outer layer is provided with insulating protrusions, and the insulating outer layer is pressed tightly into the mounting groove by the insulating protrusions.

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