Oral powder for treating allergic asthma, and preparation method therefor

Abstract

An oral powder for treating allergic asthma, and a preparation method therefor. An embodiment comprises: 20-25 g of pig bile powder, 10-15 g of fructus mume flesh, 15-25 g of dried ginger, 35-45 g of alumen, 55-60 g of pheretima, 5-6 g of aminophylline, 35-45 g of pericarpium citri reticulatae, 20-25 g of ammonium chloride, 35-45 g of sinapis semen, 60-80 g of ginsenoside Rg3, 5-10 g of honey, 30-50 g of water and 10-20 g of auxiliary materials; the ginsenoside Rg3 is a ginseng extract, and the auxiliary materials are any one among an aromatic, a coloring agent, and a flavoring agent. By means of the oral powder prepared by preparations processes S1-S6, the added ginsenoside Rg6 has anti-inflammatory and anti-tumor activity, inflammation from acute lung injury is relieved, and AHR, airway inflammation, oxidation, and eosinophil infiltration of the lungs are reduced, thereby allowing the prepared oral powder to regulate the immunity of the human body; and by reducing oxidative stress and inflammation, the pathological characteristics of asthma are improved, and consequently the therapeutic effect on the allergic asthma is improved.

Description

Oral powder for treating allergic asthma and preparation method thereof Technical Field

[0001] The present invention relates to the technical field of asthma therapeutic drugs, in particular to an oral powder for treating allergic asthma and a preparation method thereof. Background Art

[0002] Asthma is a lung disease characterized by reversible airway obstruction, airway inflammation, and increased airway responsiveness to various stimuli. Asthma airway obstruction is caused by a combination of factors, including: airway smooth muscle spasm, airway mucosal edema, increased mucus secretion, infiltration of airway wall cells (especially eosinophils and lymphocytes), airway epithelial damage and desquamation;

[0003] Among them, allergic asthma is a type of asthma that often develops in infancy and can last a lifetime if not treated. Most asthma patients have allergies or allergic rhinitis. Asthma patients with allergic rhinitis may experience symptoms such as sneezing, runny nose, itchy nose, itchy eyes, and tearing before the onset of the disease. Because the symptoms are similar to respiratory infections or inflammations, adults lack relevant knowledge and often neglect treatment in the early stages, which is also very likely to be misdiagnosed.

[0004] However, there are still some problems with the drugs used to treat allergic asthma in the prior art:

[0005] Existing allergic asthma treatment drugs, because most of the drug ingredients do not have anti-inflammatory and anti-tumor activities, fail to improve eosinophil infiltration, oxidative reactions, airway inflammation, and AHR in the lungs after entering the body, resulting in poor therapeutic effects on allergic asthma.

[0006] In response to the above problems, the inventors proposed an oral powder for treating allergic asthma and a preparation method thereof to solve the above problems. Summary of the Invention

[0007] In order to solve the problem that the existing allergic asthma treatment drugs do not have anti-inflammatory and anti-tumor activities and thus have poor treatment effects, the purpose of the present invention is to provide an oral powder for treating allergic asthma and a preparation method thereof.

[0008] To solve the above technical problems, the present invention adopts the following technical solution: an oral powder for treating allergic asthma, the components of which are calculated by weight:

[0009] 20-25g pig bile powder, 10-15g black plum meat, 15-25g dried ginger, 35-45g alum, 55-60g earthworm, 5-6g aminophylline, 35-45g tangerine peel, 20-25g ammonium chloride, 35-45g white mustard, 60-80g ginsenoside Rg3, 5-10g honey, 30-50g water and 10-20g auxiliary materials.

[0010] Preferably, the ginsenoside Rg3 is a ginseng extract.

[0011] Preferably, the auxiliary material is any one of an aromatic, a colorant and a flavoring agent.

[0012] A method for preparing an oral powder for treating allergic asthma comprises the following steps:

[0013] S1, select quantitative raw material pig gall powder, black plum meat, dried ginger, alum, earthworm, aminophylline, tangerine peel, ammonium chloride, white mustard and ginsenosides to add to a grinding device, the raw materials are pulverized and crushed into 150-200 mesh powder, then the powder and honey are added to a mixing device, the powder is mixed uniformly to obtain a mixed medicine;

[0014] S2. Add the mixture obtained in S1 into the extraction equipment, and simultaneously add a certain amount of water, and soak for 3-5 hours;

[0015] S3, decocting the soaked mixture once, and then filtering the decocted mixture once to obtain a filtrate;

[0016] S4, decocting the mixture after the first decoction for a second time, and then filtering the mixture after the second decoction to obtain a filtrate;

[0017] S5, combining the filtrates obtained in S3 and S4 to obtain an active extract, then stirring the active extract evenly and concentrating it to obtain a concentrated material;

[0018] S6. Add the concentrated material obtained in S5 to a drying device, transfer it to a crushing device after drying, and obtain a powder after crushing. Finally, add an appropriate amount of auxiliary materials to the powder to prepare a powder, and obtain an oral powder after packaging.

[0019] Preferably, in S1, the raw material is crushed to a mesh size of 150-200 mesh.

[0020] Preferably, in S3, the time for the first decoction is 2-3 hours, and in S4, the time for the second decoction is 1-2 hours.

[0021] Preferably, in S6, the dried concentrate is crushed to a size of 50-80 mesh.

[0022] Compared with the prior art, the present invention has the following beneficial effects:

[0023] In the present invention, the oral powder prepared by preparation processes S1-S6, the added ginsenoside Rg3 has anti-inflammatory and anti-tumor activities, alleviates the inflammation of acute lung injury, reduces eosinophil infiltration, oxidative reaction, airway inflammation and AHR in the lungs, so that the prepared oral powder can regulate human immunity, improve the pathological characteristics of asthma by reducing oxidative stress and inflammation, and thus improve the therapeutic effect of allergic asthma. BRIEF DESCRIPTION OF THE DRAWINGS

[0024] In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the following briefly introduces the drawings required for use in the embodiments or the description of the prior art. Obviously, the drawings described below are only some embodiments of the present invention. For ordinary technicians in this field, other drawings can be obtained based on these drawings without paying any creative work.

[0025] FIG1 is a flow chart of a method for preparing an oral powder for treating allergic asthma according to the present invention. DETAILED DESCRIPTION

[0026] The following will clearly and completely describe the technical solutions in the embodiments of the present invention in conjunction with the accompanying drawings. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without making creative efforts are within the scope of protection of the present invention.

[0027] Example: As shown in FIG1 , the present invention provides an oral powder for treating allergic asthma, the components of which are, by weight, the following:

[0028] 20-25g pig bile powder, 10-15g black plum meat, 15-25g dried ginger, 35-45g alum, 55-60g earthworm, 5-6g aminophylline, 35-45g tangerine peel, 20-25g ammonium chloride, 35-45g white mustard, 60-80g ginsenoside Rg3, 5-10g honey, 30-50g water and 10-20g auxiliary materials.

[0029] The ginsenoside Rg3 is a ginseng extract.

[0030] The auxiliary material is any one of an aromatic, a colorant and a flavoring agent.

[0031] The present invention also provides a method for preparing an oral powder for treating allergic asthma, comprising the following steps:

[0032] S1, select quantitative raw material pig gall powder, black plum meat, dried ginger, alum, earthworm, aminophylline, tangerine peel, ammonium chloride, white mustard and ginsenosides to add to a grinding device, the raw materials are pulverized and crushed into 150-200 mesh powder, then the powder and honey are added to a mixing device, the powder is mixed uniformly to obtain a mixed medicine;

[0033] S2. Add the mixture obtained in S1 into the extraction equipment, and simultaneously add a certain amount of water, and soak for 3-5 hours;

[0034] S3, decocting the soaked mixture once, and then filtering the decocted mixture once to obtain a filtrate;

[0035] S4, decocting the mixture after the first decoction for a second time, and then filtering the mixture after the second decoction to obtain a filtrate;

[0036] S5, combining the filtrates obtained in S3 and S4 to obtain an active extract, then stirring the active extract evenly and concentrating it to obtain a concentrated material;

[0037] S6. Add the concentrated material obtained in S5 to a drying device, transfer it to a crushing device after drying, and obtain a powder after crushing. Finally, add an appropriate amount of auxiliary materials to the powder to prepare a powder, and obtain an oral powder after packaging.

[0038] In S1, the raw material is crushed to a mesh size of 150-200 mesh.

[0039] In S3, the time for the first decoction is 2-3 hours, and in S4, the time for the second decoction is 1-2 hours.

[0040] In S6, the dried concentrated material is crushed into 50-80 meshes.

[0041] By adopting the above components and preparation process, ginsenoside Rg3 is added. Ginsenoside Rg3 has anti-inflammatory and anti-tumor activities, reduces inflammation of acute lung injury, and reduces eosinophil infiltration, oxidative reaction, airway inflammation and AHR in the lungs;

[0042] Ginsenoside Rg3 reduced the levels of Th2 cytokines and chemokines in bronchoalveolar lavage fluid and lungs. Inflammatory BEAS-2B cells treated with ginsenoside Rg3 reduced the expression of eosinophil chemotactic factor and proinflammatory cytokines. In addition, due to the reduced expression of ICAM-1, the adhesion of monocytes to BEAS-28 cells was significantly reduced. At the same time, the expression of reactive oxygen species in inflammatory BEAS-28 cells was reduced, thereby enabling the prepared oral powder to regulate human immunity, improve the pathological characteristics of asthma by reducing oxidative stress and inflammation, and thus improve the therapeutic effect of allergic asthma.

[0043] Obviously, those skilled in the art may make various changes and modifications to the present invention without departing from the spirit and scope of the present invention. Thus, if such changes and modifications fall within the scope of the claims and their equivalents, the present invention is intended to include such changes and modifications.

Claims

1. An oral powder for treating allergic asthma, characterized in that: The components by weight include: 20-25g pig bile powder, 10-15g black plum meat, 15-25g dried ginger, 35-45g alum, 55-60g earthworm, 5-6g aminophylline, 35-45g tangerine peel, 20-25g ammonium chloride, 35-45g white mustard, 60-80g ginsenoside Rg3, 5-10g honey, 30-50g water and 10-20g auxiliary materials.

2. An oral powder for treating allergic asthma according to claim 1, characterized in that: The ginsenoside Rg3 is a ginseng extract.

3. An oral powder for treating allergic asthma according to claim 1, characterized in that: The auxiliary material is any one of a fragrance, a colorant and a flavoring agent.

4. A method for preparing the oral powder for treating allergic asthma according to any one of claims 1 to 3, characterized in that: The following steps are involved: S1, select quantitative raw material pig gall powder, black plum meat, dried ginger, alum, earthworm, aminophylline, tangerine peel, ammonium chloride, white mustard and ginsenoside and add them into a crushing device, crush the raw materials into 150-200 mesh powder, then add the powder and honey into a mixing device, mix the powder evenly, and obtain a mixed medicine; S2, adding the mixture obtained in S1 into the extraction equipment, and simultaneously adding a certain amount of water, and soaking for 3-5 hours; S3, decocting the soaked mixture once, and then filtering the decocted mixture once to obtain a filtrate; S4, decocting the mixture after the first decoction for a second time, and then filtering the mixture after the second decoction to obtain a filtrate; S5, combining the filtrates obtained in S3 and S4 to obtain an active extract, then stirring the active extract evenly, and concentrating it to obtain a concentrated material; S6. Add the concentrated material obtained in S5 into a drying device, transfer it into a pulverizing device after drying, obtain powder after pulverizing, finally add an appropriate amount of auxiliary materials into the powder to prepare a powder, and obtain an oral powder after packaging.

5. The method for preparing an oral powder for treating allergic asthma according to claim 4, characterized in that: In S1, the raw material is crushed to a mesh size of 150-200 meshes.

6. The method for preparing an oral powder for treating allergic asthma according to claim 4, characterized in that: In S3, the first decoction time is 2-3 hours, and in S4, the second decoction time is 1-2 hours.

7. The method for preparing an oral powder for treating allergic asthma according to claim 4, characterized in that: In S6, the dried concentrated material is crushed into 50-80 meshes.

Images