Methods of producing colloidal particles suspension in AQUA of cannabinoids and of tetrahydrocannabinol converted from cannabidiol

Abstract

Methods of creating cannabinoid colloidal particles comprising combining at least a first portion of said CBD in a water-soluble solvent such that a CBD solution is created. Heating a second portion of CBD to convert it to THC. Combining the converted THC in a water-soluble solvent such that a THC solution is created. Mixing said CBD solution or the TCH solution with water, such that the CBD or THC based cannabinoid colloidal particles are created and suspended in the water and such that a CBD or THC based cannabinoid colloidal particles suspension is created.

Description

METHODS OF PRODUCING COLLOIDAL PARTICLES SUSPENSION INAQUA OF CANNABINOIDS AND OF TETRAHYDROCANNABINOL CONVERTED FROM CANNABIDIOLCROSS-REFERENCE TO RELATED APPLICATIONS

[0001] This International Application claims the benefit of and priority to U.S. Provisional Patent Application No. 63 / 583,916, filed on September 20, 2023, the contents of which are expressly incorporated herein by this reference.FIELD OF USE

[0001] The present disclosure relates, in general, to methods of producing colloidal particles suspension in aqueous medium of any cannabinoid or of tetrahydrocannabinol (THC) converted from cannabidiol (CBD).BACKGROUND

[0002] Cannabidiol (CBD) is a phytocannabinoid and is one of 113 identified cannabinoids in cannabis plants, along with tetrahydrocannabinol (THC), and accounts for up to 40% of a cannabis plant's extract. CBD can be converted into THC by several chemical reactions.

[0003] Generally, cannabinoids are chemical compounds found within the cannabis plant. They are soluble in organic solvents such as hexane, petroleum ether, alcohol, chloroform, propylene glycol and more. However, they are insoluble in water, making their incorporation into products based on water (snacks, beverages, gummies, etc.) imposable only by mixing them together, so, in order to incorporate the cannabinoids into aquas medium, current common methods being used are dissolving in solvents with the use of surfactants, emulsifying using emulsifiers, or suspensions using ultrasonic homogenizers. Importantly, these current methods that do not use emulsifiers are unstable beyond a few hours and the emulsifiers are unstable after a few weeks. Essentially, the cannabinoids are quickly separated out in the aqueous medium when using prior methods.

[0004] In order to overcome the solubility problem, cannabinoid manufacturers must use emulsifiers to create oil-in-water emulsions involving cannabinoids. From there, they may form micro-emulsions, nano-emulsions, or liposomes, which may be combinations of hydrophobic and hydrophilic materials. Using emulsions enables temporarily mixing of cannabinoid within an aqua based product, but as mentioned, the emulsion is unstable beyond a few weeks.

[0005] Emulsifiers are additives that help keep substances and / or liquids that do not normally forman incorporated mixture from separating. Emulsifiers are used in many industries including processed foods, including baked goods, to prevent oil and water from separating, and provides a smooth texture. Emulsifiers are also known as surfactants. Emulsifiers typically have one end that is attracted to and / or soluble in water and the other end that is attracted to and / or soluble in oil. Emulsifiers act as stabilizers by lowering the interfacial tensions between water and oil.

[0006] Emulsifiers can also affect the texture and mouthfeel of food and beverage products. For example, emulsifiers may be used to achieve the desired consistency and stability for a smooth sauce, a creamy dessert, or a foamy beverage.

[0007] Therefore, in order to combine the cannabinoids in an aqueous medium for a longer period of time, more than the time the emulsification method can achieve, which would be suitable commercially, what is needed is a method to suspend cannabinoids in a water-soluble solvent and in an aqueous medium without using emulsifiers, to enable stability for several months up to several years.SUMMARY

[0008] To minimize the limitations in the prior art and to minimize other limitations that will become apparent upon reading and understanding the present specification, the present disclosure discloses new and useful cannabinoid colloidal particles and methods of suspending said particle in water and / or an aqueous medium.

[0009] The following presents a simplified overview of the example embodiments in order to provide a basic understanding of some embodiments of the example embodiments. This overview is not an extensive overview of the example embodiments. It is intended to neither identify key or critical elements of the example embodiments nor delineate the scope of the appended claims. Its sole purpose is to present some concepts of the example embodiments in a simplified form as a prelude to the more detailed description that is presented herein below. It is to be understood that both the following general description and the following detailed description are exemplary and explanatory only and are not restrictive.

[0010] The advantages of the cannabinoid colloidal particles of the present disclosure are that they (i) are of a small particle size, which may allow for faster and more efficient absorption than when the cannabinoids are part of an emulsion, (ii) have are less bitter tasting as compared to emulsions, (iii) lack encapsulation by a micelle of an amphipathic substance, allowing for closer contact with tissues and more rapid absorption, and (iii) are stabile much longer than emulsions. In addition,colloidal particles size ranges between 10 nm and several microns, are able to have a higher concentration of the cannabinoid in water compared to an emulsion.

[0011] The cannabinoid colloidal particles of the present disclosure are small particles that may be suspended in a fluid I aqueous phase. Their size range is typically between 10 nm and several microns. Their relatively small size makes them small enough to be suspended in the fluid by thermal motion, because the viscosity of the water overcomes the buoyancy and prevents the movement and separation of the cannabinoid from the aqueous medium.

[0012] The cannabinoid colloidal particles of the present disclosure may comprise particles of a desired substance without emulsifying agents, using a water-soluble solvent and then creating a mixture in an aqueous medium. The cannabinoid colloidal particles of the present disclosure, when suspended in an aqueous medium, allow for fewer substances to be required part of the mixture, which prevent unwanted effects of additional substances in the system and allow greater flexibility to combine desired components in the products tow which the cannabinoids are added. Additionally, long-term stability of the cannabinoids are achieved.

[0013] When a cannabinoid product is consumed as an edible product, the cannabinoid colloidal particles of the present disclosure may reduce the degree of bitterness of the product. Emulsifiers typically have a bitter taste, and in combination with the natural bitterness of cannabinoids, a bitter product is produced. Traditionally, the bitterness is overcome by masking the bitter taste with a significant amount of sugar, flavorings, and / or decreasing the cannabinoid content of the product. The cannabinoid colloidal particles of the present disclosure remove the need to use emulsifiers, so there is a significant decrease in the bitterness of the preparation, and therefore, a greater concentration of cannabinoids may be used in the product.

[0014] The suspension stability of the cannabinoid colloidal particles suspended in an aqueous medium is longer than the stability of cannabinoid emulsions, which require using solvents and / or surfactants known for their ability to dissolve nonpolar compounds.

[0015] Table 1 below is a list of common cannabinoids and their molecular formulas.Usual Molar mass (g MolecularCannabinoid name abbreviation molx) formula(-)-trans- A9-tetrahydrocannabinol A9-THC 314.472 C21H30O2(-)-trans-A8-tetrahydrocannabinol A8-THC 314.472 C21H30O2Usual Molar mass (g MolecularCannabinoid name abbreviation mol ') formula(-)-trans-A9-tetrahydrocannabinolic THCA 358.482 C22H30O4 acid ACannabidiol CBD 314.472 C21H30O2Cannabidiolic acid CBDA 358.482 C22H30O4Cannabinol CBN 310.440 C21H26O2Cannabinolic acid CBNA 354.450 C22H26O4Cannabigerol CBG 316.488 C21H32O2Cannabigerolic acid CBGA 360.498 C22H32O4Table 1[00161 A review of the common cannabinoids in Table 1 shows that they are dominated by carbon and hydrogen, making them generally nonpolar and generally hydrophobic. However, the presence of alcohol and acid groups in the cannabinoids requires extraction solvents and solvents for creating mixtures (which are relevant to the present disclosure), to have some polarity. The presence of alcohol and acid groups in the cannabinoids requires polarity in solvent mixtures because cannabinoids are not completely nonpolar. Examples of the polar- solvents that may be used include, but are not limited to: propylene glycol, butylene glycol, mono-alcohols, di-alcohols (“diols”), tri-alcohols, and / or any water-soluble solvent capable of dissolving cannabinoids. The solvent used in the methods of the present disclosure are not surfactants and do not act as surfactants.

[0017] Furthermore, the presence of alcohol and acid groups in the cannabinoids requires polarity in solvent mixtures because cannabinoids are not completely nonpolar, and emulsifiers are not able to create a stable emulsion over a long period of time. Therefore, when suspending cannabinoid colloidal particles in aqua using the present disclosure, which is without emulsifiers and surfactants, the suspension stability depends on the buoyancy mismatch between the particles. Buoyancy refers to a particle’s density relative to a fluid into which a particle is to be dissolved (or uniformly suspended). A particle that is less dense than the fluid will float and is positivelybuoyant. A particle that is denser than the medium will sink and is negatively buoyant. A particle with the same density will float somewhere in the middle of the fluid, this is called neutral buoyancy. The greater stability of the cannabinoid colloidal particles, while suspended in an aqueous medium, is a significant improvement to using emulsifiers that only keep the cannabinoids stable in the medium for a short period of time.\

[0018] One embodiment may be a method of creating cannabinoid colloidal particles comprising: providing a cannabidiol (CBD); providing a water-soluble solvent; combining at least a first portion of the CBD in the water-soluble solvent such that a CBD solution is created; heating and stirring the first portion of the CBD and the water-soluble solvent, such that the CBD is dissolved in the CBD solution; and mixing the CBD solution with a volume of water, such that a plurality of CBD based cannabinoid colloidal particles are formed and suspended in the volume of water and such that a CBD based cannabinoid colloidal particles suspension is created. The heating of the CBD and the water-soluble solvent may be between 70 to 110°C and the stirring may be at a speed of 120 rpm or greater. The heating and the stirring of the CBD and the water-soluble solvent may be done for at least 10 minutes. The CBD solution may be combined with the volume of water at a rate of 1% by volume every 10 seconds. The CBD solution may be mixed with the volume of water in the range of approximately 5% to 25%. The water-soluble solvent may be selected from the group of solvents consisting of one or more of: propylene glycol; butylene glycol; monoalcohols; di-alcohols (“diols”); and tri-alcohols. The first portion of the CBD that may be combined with the water-soluble solvent may be at a concentration in the range of 10 to 30%. The mixing of the CBD solution with the volume of water may be done at a temperature in the range of 18 to 28°C. The method may further comprise combining a second portion of the CBD with a carboxylic acid and a catalyst, heating and stirring the second portion of the CBD, the carboxylic acid, and the catalyst, such that the CBD is converted into THC (DELTA 8) and THC (DELTA9). Combining the THC (DELTA 8) with a second catalyst, heating and stirring the THC (DELTA 8) with the second catalyst, such that the THC (DELTA 8) is converted into THC (DELTA 9). distilling the THC (DELTA 9), such that a purified THC is created, combining the THC (DELTA 9) in a second water-soluble solvent such that a THC solution is created, heating and stirring the THC (DELTA 9) and the second water-soluble solvent, such that the THC (DELTA 9) may be dissolved in the THC solution, and mixing the THC solution with a second volume of water, such that a plurality of THC based cannabinoid colloidal particles are formed and suspended in thesecond volume of water and such that a THC based cannabinoid colloidal particles suspension is created. The heating of the THC (DELTA 9) and the second water-soluble solvent may be between 70 to 110°C and the stirring may be at a speed of 120 rpm or greater. The heating and the stirring of the THC (DELTA 9) and the second water-soluble solvent may be done for at least 10 minutes. The THC solution may be combined with the second volume of water at a rate of 1% by volume every 10 seconds. The THC solution may be mixed with the second volume of water in the range of approximately 5% to 25%. The water-soluble solvent may be selected from the group of solvents consisting of one or more of: propylene glycol; butylene glycol; mono-alcohols; di-alcohols (“diols”); and tri-alcohols. The THC (DELTA 9) that may be combined with the second water- soluble solvent may be at a concentration in the range of 10 to 30%. The mixing of the THC solution with the second volume of water may be done at a temperature in the range of 18 to 28°C. The method may further comprise: combining the purified THC in a second water-soluble solvent such that a THC solution may be created; heating and stirring the purified THC and the second water-soluble solvent, such that the purified THC may be dissolved in the THC solution; and mixing the THC solution with a second volume of water, such that a plurality of THC based cannabinoid colloidal particles are formed and suspended in the second volume of water and such that a THC based cannabinoid colloidal particles suspension is created. The heating of the purified THC and the second water-soluble solvent may be between 70 to 110°C and the stirring may be at a speed of 120 rpm or greater. The heating and the stirring of the purified THC and the second water-soluble solvent may be done for at least 10 minutes. The THC solution may be combined with the second volume of water at a rate of 1% by volume every 10 seconds. The THC solution may be mixed with the second volume of water in the range of approximately 5% to 25%. The water-soluble solvent may be selected from the group of solvents consisting of one or more of: propylene glycol; butylene glycol; mono-alcohols; di-alcohols (“diols”); and tri-alcohols. The purified THC that may be combined with the second water-soluble solvent may be at a concentration in the range of 10 to 30%. The mixing of the THC solution with the second volume of water may be done at a temperature in the range of 18 to 28°C. The catalyst may be selected from the group of catalysts consisting of sodium thiosulfate; sodium sulfate, potassium sulfate, calcium dichloride, and magnesium dichloride. The second catalyst may be selected from the group of catalysts consisting of sodium thiosulfate; sodium sulfate, potassium sulfate, calcium dichloride, and magnesium dichloride.

[0019] Another embodiment may be a method of creating cannabinoid colloidal particles comprising: providing a cannabidiol (CBD); combining the CBD with a carboxylic acid and a catalyst; heating and stirring the CBD, the carboxylic acid, and the catalyst, such that the CBD may be converted into THC (DELTA 8) and THC (DELTA9); combining the THC (DELTA 8) with a second catalyst; heating and stirring the THC (DELTA 8) with the second catalyst, such that the THC (DELTA 8) may be converted into the THC (DELTA 9); combining the THC (DELTA 9) in a water-soluble solvent such that a THC solution is created; heating and stirring the THC (DELTA 9) and the water-soluble solvent, such that the THC (DELTA 9) may be dissolved in the THC solution; mixing the THC solution with a volume of water, such that a plurality of THC based cannabinoid colloidal particles are formed and suspended in the volume of water and such that a THC based cannabinoid colloidal particles suspension is created. The heating of the THC (DELTA 9) and the water-soluble solvent may be between 70 to 110°C and the stirring may be at a speed of 120 rpm or greater; wherein the heating and the stirring of the THC (DELTA 9) and the second water-soluble solvent may be done for at least 10 minutes. The THC solution may be combined with the volume of water at a rate of 1% by volume every 10 seconds. The THC solution may be mixed with the volume of water in the range of approximately 5% to 25%. The water-soluble solvent may be selected from the group of solvents consisting of one or more of: propylene glycol; butylene glycol; mono-alcohols; di-alcohols (“diols”); and tri-alcohols. The THC (DELTA 9) that may be combined with the second water-soluble solvent may be at a concentration in the range of 10 to 30%. The mixing of the THC solution with the volume of water may be done at a temperature in the range of 18 to 28°C. The method may further comprise distilling the THC (DELTA 9), such that a purified THC may be created. The method may further comprise: combining the purified THC in a second water-soluble solvent such that a purified THC solution is created; heating and stirring the purified THC and the second water-soluble solvent, such that the purified THC may be dissolved in the purified THC solution; mixing the purified THC solution with a second volume of water, such that a plurality of purified THC based cannabinoid colloidal particles are formed and suspended in the second volume of water and such that a purified THC based cannabinoid colloidal particles suspension is created. The heating of the purified THC and the second water-soluble solvent may be between 70 to 110°C and the stirring may be at a speed of 120 rpm or greater. The heating and the stirring of the purified THC and the second water-soluble solvent may be done for at least 10 minutes. The purified THC solution maybe combined with the second volume of water at a rate of 1% by volume every 10 seconds. The purified THC solution may be mixed with the second volume of water in the range of approximately 5% to 25%. The water-soluble solvent may be selected from the group of solvents consisting of one or more of: propylene glycol; butylene glycol; mono-alcohols; di-alcohols (“diols”); and tri-alcohols. The purified THC that may be combined with the second water-soluble solvent may be at a concentration in the range of 10 to 30%. The mixing of the purified THC solution with the second volume of water may be done at a temperature in the range of 18 to 28°C.

[0020] Another embodiment may be a method of creating cannabinoid colloidal particles comprising: providing a cannabidiol (CBD); providing a water-soluble solvent; combining the CBD in the water-soluble solvent such that a CBD solution is created; heating and stirring the CBD and the water-soluble solvent, such that the CBD may be dissolved in the CBD solution; and mixing the CBD solution with a volume of water, such that a plurality of CBD based cannabinoid colloidal particles are formed and suspended in the volume of water and such that a CBD based cannabinoid colloidal particles suspension is created. The heating of the CBD and the water- soluble solvent may be between 70 to 110°C and the stirring may be at a speed of 120 rpm or greater. The heating and the stirring of the CBD and the water-soluble solvent may be done for at least 10 minutes. The CBD solution may be combined with the volume of water at a rate of 1% by volume every 10 seconds; wherein the CBD solution may be mixed with the volume of water in the range of approximately 5% to 25%. The water-soluble solvent may be selected from the group of solvents consisting of one or more of: propylene glycol; butylene glycol; mono-alcohols; dialcohols (“diols”); and tri-alcohols; wherein the CBD that may be combined with the water-soluble solvent may be at a concentration in the range of 10 to 30%. The mixing of the CBD solution with the volume of water may be done at a temperature in the range of 18 to 28°C.

[0021] It is an object to overcome the limitations of the prior art.

[0022] These, as well as other components, steps, features, objects, benefits, and advantages, will now become clear from a review of the following detailed description of illustrative embodiments, the accompanying drawings, and the claims.BRIEF DESCRIPTION OF THE DRAWINGS

[0023] The drawings are of illustrative embodiments. They do not illustrate all embodiments.Other embodiments may be used in addition or instead. Details which may be apparent orunnecessary may be omitted to save space or for more effective illustration. Some embodiments may be practiced with additional components or steps and / or without all of the components or steps which are illustrated. When the same numeral appeal's in different drawings, it refers to the same or like components or steps.

[0024] Fig. 1 is an illustration of encapsulating cannabinoids in lipid-based nanoparticles cannabinoids that are well-known in the prior art.

[0025] Fig. 2 is a process flow diagram for one embodiment for producing cannabinoid colloidal particles that are suspended in an aqueous medium.

[0026] Fig. 3 is a is a process flow diagram for another embodiment for producing cannabinoid colloidal particles that are suspended in an aqueous medium.

[0027] Fig. 4 is a flow block diagram of another embodiment for producing both CBD colloidal particles that are suspended in an aqueous medium and THC colloidal particles that are suspended in an aqueous medium.DETAILED DESCRIPTION OF THE ILLUSTRATIVE EMBODIMENTS

[0028] In the following detailed description of various embodiments of the present disclosure, numerous specific details are set forth in order to provide a thorough understanding of various aspects of one or more embodiments of the present disclosure. However, one or more embodiments of the present disclosure may be practiced without some or all of these specific details. In other instances, well-known methods, procedures, and / or components have not been described in detail so as not to unnecessarily obscure aspects of embodiments of the present disclosure.

[0029] While multiple embodiments are disclosed, still other embodiments of the devices, systems, and methods of the present disclosure will become apparent to those skilled in the art from the following detailed description, which shows and describes illustrative embodiments of the devices, systems, and methods of the present disclosure. As will be realized, the devices, systems, and methods of the present disclosure are capable of modifications in various obvious aspects, all without departing from the spirit and scope of the present disclosure. Accordingly, the screenshot figures, and the detailed descriptions thereof, are to be regarded as illustrative in nature and not restrictive. Also, the reference or non-reference to a particular embodiment of the devices, systems, and methods of the present disclosure shall not be interpreted to limit the scope of the present disclosure.

[0030] Before the present methods and systems are disclosed and described, it is to be understood that the methods and systems arc not limited to specific methods, specific components, or to particular implementations. It is also to be understood that the terminology used herein is for the purpose of describing particular embodiments only and is not intended to be limiting.

[0031] As used in the specification and the appended claims, the singular forms “a,” “an,” and “the” include plural referents unless the context clearly dictates otherwise. Ranges may be expressed herein as from “about” one particular value, and / or to “about” another particular value. When such a range is expressed, another embodiment includes from the one particular value and / or to the other particular value. Similarly, when values are expressed as approximations, by use of the antecedent “about,” it will be understood that the particular value forms another embodiment. It will be further understood that the endpoints of each of the ranges are significant both in relation to the other endpoint, and independently of the other endpoint.

[0032] “Optional” or “optionally” means that the subsequently described event or circumstance may or may not occur, and that the description includes instances where said event or circumstance occurs and instances where it does not.

[0033] Throughout the description and claims of this specification, the word “comprise” and variations of the word, such as “comprising” and “comprises,” means “including but not limited to,” and is not intended to exclude, for example, other components, integers or steps. “Exemplary” means “an example of’ and is not intended to convey an indication of a preferred or ideal embodiment. “Such as” is not used in a restrictive sense, but for explanatory purposes.

[0034] Disclosed are components that may be used to perform the disclosed methods and systems. These and other components are disclosed herein, and it is understood that when combinations, subsets, interactions, groups, etc. of these components are disclosed that while specific reference of each various individual and collective combinations and permutation of these may not be explicitly disclosed, each is specifically contemplated and described herein, for all methods and systems. This applies to all embodiments of this application including, but not limited to, steps in disclosed methods. Thus, if there are a variety of additional steps that may be performed it is understood that each of these additional steps may be performed with any specific embodiment or combination of embodiments of the disclosed methods.

[0035] The present methods and systems may be understood more readily by reference to the following detailed description of preferred embodiments and the examples included therein and tothe Figures and their previous and following description.

[0036] In the following description, certain terminology is used to describe certain features of one or more embodiments. For purposes of the specification, unless otherwise specified, the term “substantially” refers to the complete or nearly complete extent or degree of an action, characteristic, property, state, structure, item, or result. For example, in one embodiment, an object that is “substantially” located within a housing would mean that the object is either completely within a housing or nearly completely within a housing. The exact allowable degree of deviation from absolute completeness may in some cases depend on the specific context. However, generally speaking, the nearness of completion will be so as to have the same overall result as if absolute and total completion were obtained. The use of “substantially” is also equally applicable when used in a negative connotation to refer to the complete or near complete lack of an action, characteristic, property, state, structure, item, or result.

[0037] As used herein, the terms “approximately” and “about” generally refer to a deviance of within 5% of the indicated number or range of numbers. In one embodiment, the term “approximately” and “about”, may refer to a deviance of between 0.001-40% from the indicated number or range of numbers.

[0038] Various embodiments are now described with reference to the drawings. In the following description, for purposes of explanation, numerous specific details are set forth in order to provide a thorough understanding of one or more embodiments. It may be evident, however, that the various embodiments may be practiced without these specific details. In other instances, well- known structures and devices are shown in block diagram form to facilitate describing these embodiments.

[0039] As used herein, the term “cannabidiol” or “CBD” refers to a compound found in marijuana I cannabis sativa. It is the second most prevalent active ingredient in cannabis. CBD is a popular natural remedy for many ailments, including pain relief and relaxation.

[0040] As used herein, the term "colloidal" refers to a mixture of an aqueous medium, in which particles with a diameter of between 1 and 1000 nm are suspended and may preferably be evenly dispersed in the medium.

[0041] As used herein, the term "cannabinoid colloidal particles" refers to particles of cannabinoids, without surfactant that are colloidally suspended in an aqueous medium. The cannabinoids may be primarily THC and / or CBD, but may also include cannabinol (CBN),cannabigerol (CBG) and / or cannabichromene (CBC) or any other cannabinoid.

[0042] As used herein, the term "cannabinoid colloidal particles suspension" refers to an aqueous medium suspension of cannabinoid colloidal particles.

[0043] As used herein, the term “decarboxylation” refers to a chemical reaction that removes a carboxyl group and releases carbon dioxide (CO2).

[0044] As used herein, the term “dissolved” refers to incorporating an element or compound into a liquid to form a solution, which is preferably homogenous.

[0045] As used herein, the term “tetrahydrocannabinol” or “THC” is the major psychoactive component and one of the 113 cannabinoids known to be found in cannabis.

[0046] As used herein, the term “weight by weight” percent or “w / w” %, refers to a method of expressing the mass percentage of a solute in a solution.

[0047] The solubility of a material may be the concentration of the solute in a steady state, saturated solution at any given temperature. The solubility of a solid typically increases with increasing temperature and may often (but not always) be greater when the melting point is lower, and the latent heat of melting is less.

[0048] Water solubility is the amount of a chemical substance that may be dissolved in water at a specific temperature. It is measured in mass per volume, usually milligrams per liter (mg / L) or parts per million (ppm). Water solubility is sometimes a result of the compound’s stability. Unstable compounds are more likely to react with water and become soluble in water. Water solubility may be low: less than 10 ppm or 10 mg / L, moderate: 10 to 1 ,000 ppm or 10 to 1 ,000 mg / L, and high: more than 1,000 ppm or 1,000 mg / L. Three factors may affect the rate of dissolution: (1) the surface area of the solute, (2) the temperature of the solvent, and (3) the amount of agitation that occurs when the solute and the solvent are mixed. When the total surface area of the solute particles is increased, the solute dissolves more rapidly. Increasing the temperature of a solvent gives the molecules more kinetic energy. The increased rapid motion means that the solvent molecules collide with the solute more frequently, and the collisions occur with more force. Both factors increase the rate at which the solute dissolves. Agitation, such as stirring, increases the dissolution rate because it continually allows fresh solvent molecules to contact the solute. Without stirring, the solute saturates the surrounding solvent, making it more difficult to dissolve the solute. Although specific Stirling revolutions per minute (rpm) are provided herein, it should be understood that the rpm may be greater than or less than the preferred rpm.

[0049] Water is a polar molecule, so it only dissolves polar solids and many ionic compounds. Water docs not dissolve nonpolar molecular compounds and docs not dissolve all ionic compounds.

[0050] Stability is the extent to which the composition of a compound stays the same under nonextreme conditions (e.g., room temperature, atmospheric pressure, and open air). Reactivity is the extent to which a compound is favored to react in certain conditions, especially when mixed with certain specific chemicals. Thus, stability usually pertains to storage conditions and shelf-life, whereas reactivity pertains to actual experimental results and safety.

[0051] One embodiment of the present disclosure may provide a method of producing cannabinoid colloidal particles that are suspended in an aqueous medium that may comprise microscopically dispersed particles suspended throughout the aqueous medium.

[0052] The cannabinoid colloidal particles of the present disclosure may comprise a small particle size, which may offer faster and more efficient absorption into the user than emulsions, a less bitter taste compared to emulsions, lack of encapsulation by a micelle of an amphipathic substance, allowing for closer contact with tissues and more rapid absorption, and significantly longer stability. From three weeks for an emulsion and from one to three years in a suspension. Cannabinoid colloidal particles may be small solid particles that may be suspended in a fluid phase. The smaller the particle, the viscosity of the water limits its ability to move according to its buoyancy, making a smaller particle more stable, while a large particle will be affected by the buoyancy significantly more than smaller particles. The size range of a cannabinoid colloidal is typically between 10 nm and several microns. This makes them small enough to be suspended in the fluid by thermal motion, provided the buoyancy mismatch between the particles and the fluid is not too large.

[0053] The cannabinoid colloidal particles and cannabinoid colloidal particles suspension of the present disclosure may comprise cannabinoid colloidal particles of a desired substance (THC, CBD, and / or other cannabinoids) without the need for emulsifying agents, using water or aqueous mixture as a solvent. The cannabinoid colloidal particles of the present disclosure allow for fewer substances to be part of the mixture. The substances not put in may negatively affect the stability of the solution or mixture by reacting with other substances that may then be incorporated into the preparation in an unwanted manner. By not having those substances and emulsifiers in the mixture, the stability of the mixture is benefited.

[0054] When a product containing the cannabinoid colloidal particles or cannabinoid colloidal particles suspension of the present disclosure is consumed, the product is less bitter than a product made with emulsified cannabinoids. Emulsifiers are typically bitter, and in combination with the natural bitterness of the cannabinoids, a bitter product is produced. Traditionally, the bitterness is overcome by masking the bitter taste with a significant amount of sugar or flavorings, and / or decreasing the potency of the cannabinoid ingredient. The cannabinoid colloidal particles of the present disclosure eliminate the need to use emulsifiers, so there is a significant decrease in the bitterness of the preparation, and therefore, a higher dose or concentration can be used.

[0055] The suspension stability of the cannabinoid colloidal particles suspension of the present disclosure is longer compared to cannabinoid emulsions using solvents known for their ability to dissolve nonpolar compounds. The presence of alcohol and acid groups requires some polarity in extraction solvents and solvent mixtures because cannabinoids are not completely nonpolar, and emulsifiers cannot create a stable emulsion with them over a long time. Therefore, when suspending cannabinoid colloidal particles in water using the present disclosure, without emulsifiers, the suspension stability depends not on the emulsifiers but on the buoyancy mismatch between the particles. This increase in suspension stability of the cannabinoid colloidal particles in water achieves better results than using an emulsion.

[0056] Fig. 1 is an illustration of encapsulating cannabinoids in lipid-based nanoparticles cannabinoids that are well-known in the prior art. As shown in Fig. 1, current and inferior methods of delivering cannabinoids may involve encapsulating the cannabinoid in lipid-based nanoparticles. Fig. 1 shows the cannabinoids encapsulated via emulsion 2, liposome 4, and solid- lipid nanoparticle 6. Each of these lipid-based nanoparticles has significant deficiencies in providing a stable, non-bitter, delivery structure for the desired cannabinoids.

[0057] Fig. 2 is a process flow diagram for one embodiment for producing cannabinoid colloidal particles that are suspended in an aqueous medium. Fig. 1 shows method 100 of creating THC based colloidal particles suspended in an aqueous medium 130. CBD 105 extract is provided or obtained. CBD 105 is converted into THC (DEETA 8) 110 and / or THC (DELTA 9) 135. The conversion may be done via heating 150 of CBD 105 in the presence of carboxylic acid 145 and one or more catalysts 140. Preferably, CBD 105 may be heated to about 70 to 155 degrees Celsius (“°C”). Applying excessive heating to CBD or other cannabinoid oils may cause it to oxidize quickly, which may affect its taste. Excessive heat may also cause cannabinoid oil to lose itsbeneficial properties and other cannabinoid features. Cannabinoids typically boil between approximately 160°C and 180°C, and care must be taken not to exceed 160°C. When cooking or baking with edible cannabinoids, it is recommended to avoid putting them on direct heat as this may remove critical beneficial compounds and terpenes that elicit the synergistic effects of cannabinoids.

[0058] The carboxylic acid 145 may be added in weight by weight (“w / w”) of approximately 30% to 50%. Carboxylic acid 145 may be selected from a group of compounds, such as, but not limited to, citric acid, malic acid, tartaric acid, formic acid, acetic acid, propionic acid, caproic acid, enanthic acid, and oxalic acid. Carboxylic acid 145 may be a chemical group that oxidizes to create the final form of cannabinoids. When heated to over 60°C, cannabinoid carboxylic acids are decarboxylated, which means they lose carbon dioxide and arc converted into neutral cannabinoids. The decarboxylation process converts tetrahydrocannabinolic acid (THCA) into THC. Decarboxylation, sometimes called “decarbing” is essential to making cannabinoid edibles. Cannabidiol acid (CBDA) is the carboxylic acid-bearing precursor to cannabinoids. During decarboxylation, the bond between the carbon from the carboxyl group and the alpha carbon cleaves, carbon dioxide (“CO2”) is released, and the desired cannabinoid is formed.

[0059] Catalyst 140 may be selected from the group of catalysts comprising sodium sulfate, potassium sulfate, calcium dichloride, magnesium dichloride, or any sodium, potassium, magnesium, or calcium salt, with elemental nonmetal substances, such as sulfur, chlorine, and oxygen.

[0060] The heating 150 of CBD 105 may be done in a container on a magnetic stirrer hot plate, stirring at approximately 120 revolutions per minute (“RPM”) or higher to increase contact between the materials. CBD 105 may be heated and stirred for approximately four (4) hours to allow all of CBD 105 material to react and be converted. Using a pressure-resistant lid may prevent the evaporation of cannabinoids.

[0061] After CBD 105 extract has been converted to THC (DELTA 8) 110 and THC (DELTA 9) 135, The next step is to convert 165 the THC (DELTA 8) 110 to THC (DELTA 9) 135. THC (DELTA 8) 110 may be heated 170 to approximately 150°C and added to catalyst 171, which may be sodium thiosulfate. Sodium thiosulfate may be substituted with another mineral salt containing thiosulfate anion, cation of sodium, potassium, or magnesium, and / or combined with an organic acid. Any substitute salt used as catalyst 171 should be added at approximately 1.0 to 5.0% w / wand stirred at a speed of approximately 120 rpm or higher. Using a pressure-resistant vessel with a lid may help prevent the evaporation of the cannabinoids. Preferably, the solution is heated and stirred for approximately 3 to 4 hours.

[0062] In one embodiment, the THC (DELTA 9) 135 mixture created may be distilled 112 to further isolate the THC cannabinoids. Specifically, THC (DELTA 9) 135 may be heated to the temperature of the desired cannabinoid’s boiling point, which in this case would be about 104°C. This allows the THC DELTA 9 component to vaporize. The vaporized THC DELTA 9 steam or vapor may be collected via condensation, and the collected condensation contains purified THC DELTA 9 cannabinoids.

[0063] THC (DELTA 9) 135 and / or the distilled THC DELTA 9 collected liquid 113 may now be dissolved 185 in a water-soluble solvent 180. Water-soluble solvent 180 may be, but is not limited to, propylene glycol, butylene glycol, mono-alcohols, di-alcohols (“diols”), tri-alcohols, and / or any water-soluble solvent capable of dissolving cannabinoids, at a preferred concentration of approximately 0.1% to 50%. A more preferred concentration is between approximately 10% to 30%. Preferably, the water-soluble solvent 180 is added to THC (DELTA 9) 135 and / or the distilled THC DELTA 9 collected liquid 113 while heating to about a temperature of approximately 70 to 110°C and while Stirling at a speed of 120 rpm or greater. The heating and stirring may preferably be done for about ten minutes or longer. Next, the resulting THC based solution 115 may be cooled to room temperature. Once cooled, THC based solution 115 may be mixed 120 with water to create THC based cannabinoid colloidal particles that are suspended in an aqueous suspension 130. Mixing 120 may be completed at room temperature, preferably without heating or cooling (temperature may preferably be in the range of approximately 18 to 28°C). Mixing 120 may be accomplished while stirring at a speed of approximately 120 rpm or greater. THC based solution 115 may preferably be added at a rate of approximately 1% every 10 seconds to the swirling water. THC solution 115 may be mixed with aqua in the range of approximately 5% (one (1) part CBD based solution 115 to nineteen (19) parts aqua) to 25% (one (1) pail CBD based solution 115 to three (3) parts aqua).

[0064] Once THC based cannabinoid colloidal particles that are suspended in an aqueous suspension 130 is formed, it may be stored or used. The THC colloidal particles of suspension 130 are very small and are, thus, reactive to radiation and oxidizing substances such as light and oxygen. Aqueous suspension 130 should be transferred to an opaque sealed container to avoiddegradation. Although an add rate of approximately 1 % is preferred, greater or lesser rates may be used without deviating from the scope of the present disclosure.

[0065] Fig. 3 is a is a process flow diagram for another embodiment for producing cannabinoid colloidal particles that are suspended in an aqueous medium. Fig. 2 shows method 200 of creating CBD based colloidal particles suspended in an aqueous medium 220. CBD 205 extract is provided or obtained. CBD 205 may be dissolved 210 in water-soluble solvent 211. Water-soluble solvent 211 may be, but is not limited to, propylene glycol, butylene glycol, mono-alcohols, di-alcohols (“diols”), tri-alcohols, and / or any water-soluble solvent capable of dissolving cannabinoids, at a preferred concentration of approximately 0.1% to 50%. A more preferred concentration is between approximately 10% to 30%. Preferably, water-soluble solvent 211 is added to CBD 205 while heating to about a temperature of approximately 70 to 110°C and while stirring at a speed of 120 rpm or greater. The heating and stirring may preferably be done for about ten minutes or longer. Next, the resulting CBD based solution 215 may be cooled to room temperature. Once cooled, CBD based solution 215 may be mixed 221 with water to create the CBD based cannabinoid colloidal particles that are suspended in an aqueous medium 220. Mixing 221 may be completed at room temperature, preferably without heating or cooling (temperature may be in the range of approximately 18 to 28°C). Mixing 221 may be accomplished while stirring at a speed of approximately 120 rpm or greater. CBD based solution 215 may preferably be added at a rate of approximately 1% every 10 seconds to the swirling water. CBD solution 215 may be mixed with aqua in the range of approximately 5% (one (1 ) part CBD based solution 215 to nineteen (19) parts aqua) to 25% (one (1) part CBD based solution 215 to three (3) parts aqua)

[0066] Once CBD based cannabinoid colloidal particles that are suspended in an aqueous medium 220 is formed, it may be stored or used. The CBD colloidal particles are very small and are, thus, reactive to radiation and oxidizing substances such as light and oxygen. Aqueous medium 220 should be transferred to an opaque sealed container to avoid degradation.

[0067] Fig. 4 is a flow block diagram of another embodiment for producing both CBD colloidal particles that are suspended in an aqueous medium and THC colloidal particles that are suspended in an aqueous medium or aqua. As shown in Fig. 4, one embodiment may be a method of creating both CBD colloidal particles that are suspended in an aqueous medium and THC colloidal particles that are suspended in an aqueous medium. The method 400 may comprise the steps: providing a cannabidiol (CBD) and a water-soluble solvent, which may be, for example, propylene glycol, orother suitable polar and / or alcohol solvent 402; combining at least a first portion of the CBD in the water-soluble solvent such that a CBD solution is created 404; Heating and stirring the first portion of the CBD and the water-soluble solvent, such that the CBD is dissolved in the CBD solution 406; and mixing the CBD solution with a volume of water or other aqueous medium, such that a plurality of CBD based cannabinoid colloidal particles are formed and suspended in the aqua and such that a CBD based cannabinoid colloidal particles suspension is created 408.

[0068] The method may further comprise the steps: combining a second portion of the CBD with a carboxylic acid and a catalyst, heating and stirring the second portion of the CBD, the carboxylic acid, and the catalyst, such that the CBD is converted into THC (DELTA 8) and THC (DELTA9) 420; and combining the THC (DELTA 8) with a second catalyst, heating and stirring the THC (DELTA 8) with the second catalyst, such that the THC (DELTA 8) is converted into THC (DELTA 9) 422. Optionally, some portion of the THC (DELTA 9) may be distilled via step: Distilling the THC (DELTA 9), such that a purified THC is created 424. Finally, the THC (DELTA 9), from the original conversion, the THC (DELTA 8) conversion, and / or the distilled THC, is processed to create the colloidal via the steps: combining the THC (DELTA 9) in a second water-soluble solvent (which may be the same as the first), such that a THC solution is created, heating and stirring the THC (DELTA 9) and the second water-soluble solvent, such that the THC (DELTA 9) may be dissolved in the THC solution, and mixing the THC solution with a second volume of water or other aqueous medium, such that a plurality of THC based cannabinoid colloidal particles are formed and suspended in the aqua, and such that a THC based cannabinoid colloidal particles suspension is created 426.

[0069] Unless otherwise stated, all measurements, values, ratings, positions, magnitudes, sizes, locations, and other specifications that are set forth in this specification, including in the claims that follow, are approximate, not exact. They are intended to have a reasonable range that is consistent with the functions to which they relate and with what is customary in the art to which they pertain.

[0070] The foregoing description of the preferred embodiment has been presented for the purposes of illustration and description. While multiple embodiments are disclosed, still other embodiments will become apparent to those skilled in the art from the above detailed description. These embodiments are capable of modifications in various obvious aspects, all without departing from the spirit and scope of protection. Accordingly, the detailed description is to be regarded asillustrative in nature and not restrictive. Also, although not explicitly recited, one or more embodiments may be practiced in combination or conjunction with one another. Furthermore, the reference or non-reference to a particular embodiment shall not be interpreted to limit the scope of protection. It is intended that the scope of protection not be limited by this detailed description, but by the claims and the equivalents to the claims that are appended hereto.

[0071] Except as stated immediately above, nothing that has been stated or illustrated is intended or should be interpreted to cause a dedication of any component, step, feature, object, benefit, advantage, or equivalent, to the public, regardless of whether it is or is not recited in the claims.

Claims

CLAIMSWhat is claimed is:

1. A method of creating cannabinoid colloidal particles comprising: providing a cannabidiol (CBD); providing a water-soluble solvent; combining at least a first portion of said CBD in said water-soluble solvent such that a CBD solution is created; heating and stirring said first portion of said CBD and said water-soluble solvent, such that said CBD is dissolved in said CBD solution;2. The method of claim 1, further comprising: mixing said CBD solution with a volume of water, such that a plurality of CBD based cannabinoid colloidal particles are formed and suspended in said volume of water and such that a CBD based cannabinoid colloidal particles suspension is created.

3. The method of claim 2, wherein said heating of said CBD and said water-soluble solvent is between 70 to 110°C and said stirring is at a speed of 120 rpm or greater.

4. The method of claim 3, wherein said heating and said stirring of said CBD and said water-soluble solvent is done for at least 10 minutes.

5. The method of claim 2, wherein said CBD solution is combined with said volume of water at a rate of 1 % by volume every 10 seconds.

6. The method of claim 2, wherein said CBD solution is mixed with said volume of water in the range of approximately 5% to 25%.

7. The method of claim 2, wherein said water-soluble solvent is selected from the group of solvents consisting of one or more of: propylene glycol; butylene glycol; monoalcohols; di-alcohols (“diols”); and tri-alcohols.

8. The method of claim 2, wherein said first portion of said CBD that is combined with said water-soluble solvent is at a concentration in the range of 10 to 30%.

9. The method of claim 2, wherein said mixing of said CBD solution with said volume of water is done at a temperature in the range of 18 to 28°C.

10. The method of claim 1, further comprising: combining a second portion of said CBD with a carboxylic acid and a catalyst;heating and stirring said second portion of said CBD, said carboxylic acid, and said catalyst, such that said CBD is converted into THC (DELTA 8) and THC (DELTA9).

11. The method of claim 10, further comprising: combining said THC (DELTA 8) with a second catalyst; heating and stirring said THC (DELTA 8) with said second catalyst, such that said THC (DELTA 8) is converted into said THC (DELTA 9).

12. The method of claim 11, further comprising: distilling said THC (DELTA 9), such that a purified THC is created.

13. The method of claim 11, further comprising: combining said THC (DELTA 9) in a second water-soluble solvent such that a THC solution is created; and heating and stirring said THC (DELTA 9) and said second water-soluble solvent, such that said THC (DELTA 9) is dissolved in said THC solution.

14. The method of claim 13, further comprising: mixing said THC solution with a second volume of water, such that a plurality of THC based cannabinoid colloidal particles are formed and suspended in said second volume of water and such that a THC based cannabinoid colloidal particles suspension is created; wherein said heating of said THC (DELTA 9) and said second water-soluble solvent is between 70 to 110°C and said stirring is at a speed of 120 rpm or greater; wherein said heating and said stirring of said THC (DELTA 9) and said second water- soluble solvent is done for at least 10 minutes; wherein said THC solution is combined with said second volume of water at a rate of1% by volume every 10 seconds; wherein said THC solution is mixed with said second volume of water in the range of approximately 5% to 25%; wherein said water-soluble solvent is selected from the group of solvents consisting of one or more of: propylene glycol; butylene glycol; mono-alcohols; di-alcohols (“diols”); and tri-alcohols; wherein said THC (DELTA 9) that is combined with said second water-soluble solventis at a concentration in the range of 10 to 30%; wherein said mixing of said THC solution with said second volume of water is done at a temperature in the range of 18 to 28°C.

15. The method of claim 12, further comprising: combining said purified THC in a second water-soluble solvent such that a THC solution is created; heating and stirring said purified THC and said second water-soluble solvent, such that said purified THC is dissolved in said THC solution; mixing said THC solution with a second volume of water, such that a plurality of THC based cannabinoid colloidal particles are formed and suspended in said second volume of water and such that a THC based cannabinoid colloidal particles suspension is created; wherein said heating of said purified THC and said second water-soluble solvent is between 70 to 110°C and said stirring is at a speed of 120 rpm or greater; wherein said heating and said stirring of said purified THC and said second water- soluble solvent is done for at least 10 minutes; wherein said THC solution is combined with said second volume of water at a rate of 1% by volume every 10 seconds.

16. The method of claim 15, wherein said THC solution is mixed with said second volume of water in the range of approximately 5% to 25%. wherein said water-soluble solvent is selected from the group of solvents consisting of one or more of: propylene glycol; butylene glycol; mono-alcohols; di-alcohols (“diols”); and tri-alcohols; wherein said purified THC that is combined with said second water-soluble solvent is at a concentration in the range of 10 to 30%; wherein said mixing of said THC solution with said second volume of water is done at a temperature in the range of 18 to 28°C.

17. The method of Claim 14, wherein said catalyst is selected from the group of catalysts consisting of sodium thiosulfate; sodium sulfate, potassium sulfate, calcium dichloride, and magnesium dichloride.

18. The method of Claim 16, wherein said second catalyst is selected from the group ofcatalysts consisting of sodium thiosulfate; sodium sulfate, potassium sulfate, calcium dichloridc, and magnesium dichloridc.

19. A method of creating cannabinoid colloidal particles comprising: providing a cannabidiol (CBD); combining said CBD with a carboxylic acid and a catalyst; heating and stirring said CBD, said carboxylic acid, and said catalyst, such that said CBD is converted into THC (DELTA 8) and THC (DELTA9); combining said THC (DELTA 8) with a second catalyst; heating and stirring said THC (DELTA 8) with said second catalyst, such that said THC (DELTA 8) is converted into said THC (DELTA 9); combining said THC (DELTA 9) in a water-soluble solvent such that a THC solution is created; heating and stirring said THC (DELTA 9) and said water-soluble solvent, such that said THC (DELTA 9) is dissolved in said THC solution; mixing said THC solution with a volume of water, such that a plurality of THC based cannabinoid colloidal particles are formed and suspended in said volume of water and such that a THC based cannabinoid colloidal particles suspension is created. wherein said heating of said THC (DELTA 9) and said water-soluble solvent is between 70 to 1 10°C and said stirring is at a speed of 120 rpm or greater; wherein said heating and said stirring of said THC (DELTA 9) and said second water- soluble solvent is done for at least 10 minutes; wherein said THC solution is combined with said volume of water at a rate of 1 % by volume every 10 seconds; wherein said THC solution is mixed with said volume of water in the range of approximately 5% to 25%; wherein said water-soluble solvent is selected from the group of solvents consisting of one or more of: propylene glycol; butylene glycol; mono-alcohols; di-alcohols (“diols”); and tri-alcohols; wherein said THC (DELTA 9) that is combined with said second water-soluble solvent is at a concentration in the range of 10 to 30%;wherein said mixing of said THC solution with said volume of water is done at a temperature in the range of 18 to 28°C.

20. The method of claim 19, further comprising: distilling said THC (DELTA 9), such that a purified THC is created.

21. The method of claim 20, further comprising: combining said purified THC in a second water-soluble solvent such that a purified THC solution is created; heating and stirring said purified THC and said second water-soluble solvent, such that said purified THC is dissolved in said purified THC solution; mixing said purified THC solution with a second volume of water, such that a plurality of purified THC based cannabinoid colloidal particles are formed and suspended in said second volume of water and such that a purified THC based cannabinoid colloidal particles suspension is created; wherein said heating of said purified THC and said second water-soluble solvent is between 70 to 110°C and said stirring is at a speed of 120 rpm or greater; wherein said heating and said stirring of said purified THC and said second water- soluble solvent is done for at least 10 minutes; wherein said purified THC solution is combined with said second volume of water at a rate of 1% by volume every 10 seconds; wherein said purified THC solution is mixed with said second volume of water in the range of approximately 5% to 25%; wherein said water-soluble solvent is selected from the group of solvents consisting of one or more of: propylene glycol; butylene glycol; mono-alcohols; di-alcohols (“diols”); and tri-alcohols; wherein said purified THC that is combined with said second water-soluble solvent is at a concentration in the range of 10 to 30%; wherein said mixing of said purified THC solution with said second volume of water is done at a temperature in the range of 18 to 28°C.

22. A method of creating cannabinoid colloidal particles comprising: providing a cannabidiol (CBD); providing a water-soluble solvent;combining said CBD in said water-soluble solvent such that a CBD solution is created; heating and stirring said CBD and said water-soluble solvent, such that said CBD is dissolved in said CBD solution; mixing said CBD solution with a volume of water, such that a plurality of CBD based cannabinoid colloidal particles are formed and suspended in said volume of water and such that a CBD based cannabinoid colloidal particles suspension is created; wherein said heating of said CBD and said water-soluble solvent is between 70 to 110°C and said stirring is at a speed of 120 rpm or greater; wherein said heating and said stirring of said CBD and said water-soluble solvent is done for at least 10 minutes; wherein said CBD solution is combined with said volume of water at a rate of 1% by volume every 10 seconds; wherein said CBD solution is mixed with said volume of water in the range of approximately 5% to 25%; wherein said water-soluble solvent is selected from the group of solvents consisting of one or more of: propylene glycol; butylene glycol; mono-alcohols; di-alcohols (“diols”); and tri-alcohols; wherein said CBD that is combined with said water-soluble solvent is at a concentration in the range of 10 to 30%; wherein said mixing of said CBD solution with said volume of water is done at a temperature in the range of 18 to 28°C.

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