Apparatus, system and method for automated execution of bubble test

Abstract

An apparatus (100), system and method for automated execution of a bubble test. The apparatus (100) comprises a container (110) for accommodating normal saline, a pipeline (120), a first syringe (160), a second syringe (170), a first valve (130), a second valve (140), and a third valve (100). By using the apparatus (100) to perform the bubble test, the accuracy of the results of the bubble test can be improved while the time for the bubble test is shortened. When the apparatus (100) is used to perform a right heart contrast test, the apparatus (100) can automatically draw normal saline, blood, and air, and the preparation and injection of a contrast agent are automatically carried out by means of the repeated pushing and pulling of the first syringe (160) and the second syringe (170). When the apparatus (100) is used to perform a left heart contrast test, normal saline and a left heart contrast agent can be manually or automatically mixed, then the contrast agent is uniformly mixed by using a uniform mixing apparatus or the left heart contrast agent is uniformly mixed by means of the repeated pushing and pulling of the first syringe (160) and the second syringe (170), so as to form microbubbles, and finally, the microbubble contrast agent is injected into a human body. The apparatus (100) can be used to perform not only the right heart contrast test but also the left heart contrast test, thereby greatly improving the utilization rate of the apparatus.

Description

Device, system and method for automating foaming test

[0001] CROSS-REFERENCE TO RELATED APPLICATIONS

[0002] This application claims priority to Chinese patent application No. 202311720518.8, filed with the Chinese Patent Office on December 14, 2023, and entitled “Device and method for automatically performing foaming tests”, and Chinese patent application No. 202422939725.9, filed with the Chinese Patent Office on November 28, 2024, and entitled “Device for automatically performing foaming tests”, the entire contents of which are incorporated by reference into this application. Technical Field

[0003] The present application relates to the field of medical device technology, and in particular to a device, system and method for automatically performing a foaming test. Background Art

[0004] The 2022 "Chinese Expert Consensus on Right Heart Echocardiography in Patent Foramen Ovale" states that the indications for the bubble test include: 1) screening for suspected left-to-right or right-to-left shunts, such as patent foramen ovale (PFO); 2) diagnosis of congenital vascular malformations, such as persistent left superior vena cava and pulmonary arteriovenous fistula; 3) assessment of right cardiac cavity diameter, endocardial border contour, ventricular wall thickness, presence of mass and valvular regurgitation; and 4) identification of the cause of hypoxemia. In other words, the bubble test can be used for screening tests for a variety of diseases.

[0005] In the foaming test, it is necessary to extract physiological saline, blood and air for mixing to obtain a microbubble contrast agent, and then inject the microbubble contrast agent into the human body for subsequent tests. Among them, the extraction of physiological saline is usually done manually, and each test requires manual extraction of physiological saline, which is cumbersome. And if multiple foaming tests are required for the same person, the same set of consumables (including syringes, injection pipes and valves) are usually used. It is inconvenient to clean the consumables between each foaming test, and the residual liquid in the pipeline will affect the accuracy of the next foaming test. In addition, in each foaming test, the microbubble contrast agent remaining in the pipeline cannot be completely injected into the human body, and the insufficient amount of microbubble contrast agent entering the human body will also affect the accuracy of the subsequent foaming test results.

[0006] Application Contents

[0007] The present application mainly provides a device, system and method for automatically performing a foaming test. The device can automatically extract physiological saline, and when performing a foaming test, the microbubble contrast agent can be injected into the human body as much as possible. The pipeline can also be cleaned after a foaming test, shortening the foaming test time while improving the accuracy of the foaming test results.

[0008] According to the first aspect of the present application, an embodiment provides a device for automatically performing a foaming test, comprising: a container configured to contain physiological saline; a pipeline having a first end and a second end arranged opposite to each other, the first end being configured to be connected to the container, and the second end being configured to be connected to an external indwelling needle; a first syringe and a second syringe being configured to perform push injection and / or extraction actions; a first valve being arranged on the pipeline, which has at least three interfaces, two of which are configured to connect to the pipeline, and at least one other interface being configured to connect to the outside world; a second valve being arranged on the pipeline, which has at least three interfaces, two of which are configured to connect to the pipeline, and at least one other interface being configured to connect to the first syringe; a third valve being arranged on the pipeline, which has at least three interfaces, two of which are configured to connect to the pipeline, and at least one other interface being configured to connect to the second syringe; the first valve, the second valve, and the third valve are connected along a line from The direction from the first end to the second end is set in sequence; the device configured to automatically perform the foaming test can switch to different working modes. When switched to the first pipeline mode, the first valve and the second valve are set to connect the liquid path between the container and the first syringe; when switched to the second pipeline mode, the first valve, the second valve and the third valve are set to connect the liquid path between the container and the second syringe; when switched to the third pipeline mode, the first valve, the second valve and the third valve are set to connect the liquid path between the outside and the second syringe; when switched to the fourth pipeline mode, the third valve is set to connect the liquid path between the second syringe and the external indwelling needle; when switched to the fifth pipeline mode, the second valve and the third valve are set to connect the liquid path between the first syringe and the external indwelling needle; when switched to the sixth pipeline mode, the second valve and the third valve are set to connect the liquid path between the first syringe and the second syringe.

[0009] The present application provides a device for automatically performing a foaming test. The first end of the device's pipeline is connected to a container containing physiological saline. Due to the automated configuration of the entire system, the device can automatically draw physiological saline. Furthermore, because the container, a first syringe, and a second syringe are arranged sequentially from the first end to the second end of the pipeline, after the second syringe draws blood, the first syringe can push the previously drawn physiological saline into the human body to clean the blood in the pipeline. Furthermore, after the foaming liquid is injected into the human body, since foaming liquid still remains in the pipeline, the second syringe, after drawing the physiological saline and pushing the physiological saline into the human body, can also push the foaming liquid in the pipeline into the human body. At this point, the remaining liquid in the pipeline is a combination of foaming liquid and physiological saline. Then, the first syringe can push the physiological saline into the human body again, further pushing the foaming liquid in the pipeline into the human body, making the pipeline cleaner. If the foaming test fails in the control group or the experimental group, the next experiment can be performed directly without replacing the pipeline, the first syringe, or the second syringe. This improves the accuracy of the foaming test and saves time.

[0010] According to the second aspect of the present application, an embodiment provides a system for automatically performing a foaming test, comprising any of the aforementioned devices for automatically performing a foaming test, and further comprising a mixing device, and a third container contained in the mixing device, the mixing device being configured to drive the third container to move so that the contrast agent contained in the third container is fully dissolved in the physiological saline to form a uniform contrast mixture, and to cause the contrast mixture to foam; wherein the mixing device is integrated into the foaming test device, or the mixing device is independent of the foaming test device.

[0011] According to a third aspect of the present application, an embodiment provides a method for automatically performing a foaming test, which is performed using the apparatus for automatically performing a foaming test as described above. The method comprises the following steps:

[0012] The preparation step includes: switching the device to the first pipeline mode, controlling the first syringe to extract physiological saline from the container; then switching the device to the second pipeline mode, controlling the second syringe to extract physiological saline from the container; then switching the device to the fourth pipeline mode, controlling the second syringe to discharge the physiological saline from the indwelling needle; then switching the device to the fifth pipeline mode, controlling the first syringe to discharge the physiological saline from the indwelling needle; wherein, when the first syringe and the second syringe discharge the physiological saline from the indwelling needle, the first syringe and the second syringe are both pushed to the bottom to remove the air in the first syringe and the second syringe. The mixed liquid extraction step includes: switching the device to the first pipeline mode, controlling the first syringe to extract physiological saline from the container; then switching the device to the second pipeline mode, controlling the second syringe to extract physiological saline from the container; then switching the device to the third pipeline mode, controlling the second syringe to extract air from the outside; then switching the device to the fourth pipeline mode, controlling the second syringe to extract blood from the human body through the indwelling needle to obtain a mixed liquid; then switching the device to the fifth pipeline mode, controlling the first syringe to inject physiological saline into the human body; the foaming liquid preparation step includes: switching the device to the sixth pipeline mode, controlling the second syringe to extract blood from the human body through the indwelling needle to obtain a mixed liquid. The pipeline mode controls the first syringe and the second syringe to push the mixed liquid back and forth, and the sum of the number of pushes by the first syringe and the second syringe is an even number to obtain a foaming liquid; the first foaming liquid injection step comprises: after obtaining the foaming liquid, switching the device to the fourth pipeline mode, controlling the second syringe to inject the foaming liquid into the human body; the first tube sealing step comprises: after the first foaming liquid injection step, switching the device to the second pipeline mode, controlling the second syringe to extract physiological saline from the container; then switching the device to the first pipeline mode, controlling the first syringe to extract physiological saline from the container; and then switching the device to the first pipeline mode. Switching to the fourth pipeline mode, controlling the second syringe to inject physiological saline into the human body; then switching the device to the fifth pipeline mode, controlling the first syringe to inject physiological saline into the human body, thereby completing the foaming test of the control group; the second foaming liquid injection step, which includes: repeating the mixed liquid extraction step and the foaming liquid preparation step once, after obtaining the foaming liquid, when the patient's blowing or Eustachian tube inflation test action meets the standard, switching the device to the fourth pipeline mode, controlling the second syringe to inject the foaming liquid into the human body; the second tube sealing step includes: repeating the first tube sealing step, thereby completing the foaming test of the test group.

[0013] According to a fourth aspect of the present application, an embodiment provides a device for automatically performing a foaming test, comprising: a pipeline having a first end and a second end arranged opposite to each other, the first end being configured to be connected to a first container, the first container being configured to accommodate a contrast mixture, and the second end being configured to be connected to an external indwelling needle; a first syringe and a second syringe being configured to perform push injection and / or extraction actions, respectively; a second valve being arranged on the pipeline, having at least three interfaces, two of which are configured to connect to the pipeline, and at least one other interface being configured to connect to the first syringe; a third valve being arranged on the pipeline, having at least three interfaces, two of which are configured to connect to the pipeline, and at least one other interface being configured to connect to the first syringe. The apparatus comprises a first port, a second port, a second port, and a second port. The second port comprises a first port, a second port, and a second port. The second port comprises a first port, a second port, and a second port. The second port comprises a first port, a second port, and a second port. The second port comprises a first port, a second port, and a second port. The second port comprises a first port, a second port, and a second port. The second port comprises a first port, a second port, and a second port. The second port comprises a first port, a second port, and a second port.

[0014] When left atrial angiography is required, first, a contrast mixture prepared by mixing physiological saline and powdered contrast agent is contained in a first container, and then the device is switched to the left atrial angiography working mode. At this time, the device will automatically perform a foaming experiment. When the device switches to the first pipeline state, the second valve is connected between the first container and the first syringe, and the second valve closes the pipeline between the first syringe and the third valve. At this time, the first syringe will extract the contrast mixture from the first container. After the first syringe completes the extraction of the contrast mixture, the device switches to the second pipeline state, the second valve and the third valve connect the pipeline between the first syringe and the second syringe, and the second valve closes the pipeline between the first syringe and the first container, and the third valve closes the pipeline between the second syringe and the second end. At this time, the first syringe and the second syringe cooperate with each other to reciprocally inject the contrast mixture until bubble liquid is formed, thereby improving the efficiency of injecting the contrast mixture and shortening the time for the contrast mixture to form bubble liquid, so that the contrast mixture can quickly form bubble liquid in the second pipeline state, completing the automatic preparation of left atrial contrast bubble liquid, and thereby improving the quality, preparation efficiency and consistency of the bubble liquid. BRIEF DESCRIPTION OF THE DRAWINGS

[0015] FIG1 is a schematic diagram of a structure of a device for automatically performing a foaming test according to the present application;

[0016] FIG2 is a schematic diagram of a partial structure of a device for automatically performing a foaming test according to the present application;

[0017] FIG3 is a schematic diagram of a dust cover opening of a device for automatically performing a foaming test according to the present application;

[0018] FIG4 is another schematic diagram of a partial structure of a device for automatically performing a foaming test according to the present application;

[0019] FIG5 is a schematic structural diagram of a device for automatically performing a foaming test in accordance with the present application, in combination with an air blowing device;

[0020] FIG6 is a schematic diagram of a structure of a system for automatically performing a foaming test according to the present application;

[0021] FIG7 is a second structural schematic diagram of a system for automatically performing a foaming test according to the present application;

[0022] FIG8 is a schematic diagram of another overall device for automatically performing a foaming test according to the present application;

[0023] FIG9 is a schematic diagram of the pipeline connection state in FIG8;

[0024] FIG10 is a schematic diagram of FIG9 from another perspective;

[0025] FIG11 is a second overall schematic diagram of another device for automatically performing a foaming test according to the present application;

[0026] FIG12 is a third overall schematic diagram of another device for automatically performing a foaming test according to the present application;

[0027] FIG13 is a schematic diagram of the pipeline connection state in FIG12;

[0028] FIG14 is a fourth overall schematic diagram of another device for automatically performing a foaming test according to the present application.

[0029] Figure 1: Device for automating the foaming test 100, container 110, third container 101, pipeline 120, first end 121, second end 122, first valve 130, second valve 140, third valve 150, first syringe 160, second syringe 170, first syringe driver 180, first syringe driver output 181, second syringe driver 190, second syringe driver output 191, air filter 200, first ultrasonic bubble sensor 210, second ultrasonic bubble sensor 220, blood oxygen detection sensor 230, micro camera 240, first thrust Sensor-250, second thrust sensor-260, dust cover device-270, blowing device-300, mixing device-400, device 100′, first container 101′, second container 110′, pipeline 120′, first end 121′, second end 122′, first sub-pipeline 123′, second sub-pipeline 124′, third end 125′, fourth end 126′, first valve 130′, second valve 140′, third valve 150′, first syringe 160′, second syringe 170′, air filter 200′, hanger 280′, support arm 281′, first hanging arm 282′, second hanging arm 283′, blowing device 300′. DETAILED DESCRIPTION

[0030] The present application is further described in detail below by means of specific embodiments in conjunction with the accompanying drawings. Similar elements in different embodiments are numbered with associated similar elements. In the following embodiments, many detailed descriptions are provided to enable the present application to be better understood. Those skilled in the art will readily appreciate that some of the features may be omitted in different circumstances, or may be replaced by other elements, materials, or methods. In some cases, some operations related to the present application are not shown or described in the specification. This is to avoid the core portion of the present application being overwhelmed by excessive descriptions. For those skilled in the art, it is not necessary to describe these related operations in detail. They can fully understand the related operations based on the description in the specification and the general technical knowledge in the art.

[0031] The features, operations, or characteristics described in this specification may be combined in any appropriate manner to form various embodiments. Furthermore, the steps or actions in the method description may be reordered or adjusted in a manner readily apparent to those skilled in the art. Therefore, the various sequences in the specification and drawings are provided solely for the purpose of describing a particular embodiment and are not intended to be mandatory, unless otherwise specified.

[0032] The serial numbers assigned to components herein, such as "first," "second," etc., are used solely to distinguish the objects being described and do not convey any sequential or technical meaning. References to "connection" and "coupling" herein, unless otherwise specified, include both direct and indirect connections (couplings).

[0033] This embodiment provides a device 100 for automatically performing a foaming test, hereinafter referred to as a foaming test device. Please refer to Figures 1 to 5. The foaming test device 100 includes a container 110, a pipeline 120, a first valve 130, a second valve 140, a third valve 150, a first syringe 160 and a second syringe 170.

[0034] Referring to Figures 1 and 2, container 110 is filled with physiological saline. Pipeline 120 has a first end 121 and a second end 122, which are arranged opposite each other. First end 121 is in communication with container 110, and second end 122 is configured to communicate with an indwelling needle. A first valve 130 is disposed on pipeline 120. First valve 130 has multiple ports, two of which are connected to pipeline 120 and configured to communicate with pipeline 120, and another port is configured to communicate with the outside world. A second valve 140 is disposed on pipeline 120. Second valve 140 has multiple ports, two of which are connected to pipeline 120 and configured to communicate with pipeline 120. A third valve 150 is disposed on pipeline 120. Third valve 150 has multiple ports, two of which are connected to pipeline 120 and configured to communicate with pipeline 120. First valve 130, second valve 140, and third valve 150 are arranged in order from first end 121 toward second end 122. The first syringe 160 is connected to one of the interfaces of the second valve 140. The second syringe 170 is connected to one of the interfaces of the third valve 150. Furthermore, the foaming test device 100 further includes a first valve driver, a second valve driver, and a third valve driver. Each of the first, second, and third valve drivers is a motor. The first valve driver is connected to the first valve 130 and configured to switch the operating state of the first valve 130. The second valve driver is connected to the second valve 140 and configured to switch the operating state of the second valve 140. The third valve driver is connected to the third valve 150 and configured to switch the operating state of the third valve 150. Furthermore, the first, second, and third valve drivers are all electrically connected to a control system, which is configured to control the operating modes of the first, second, and third valve drivers.

[0035] The foaming test device 100 can be switched between different operating modes. When the foaming test device 100 is switched to the first pipeline mode, the first valve 130 and the second valve 140 connect the fluid path between the container 110 and the first syringe 160. When the foaming test device 100 is switched to the second pipeline mode, the first valve 130, the second valve 140, and the third valve 150 connect the fluid path between the container 110 and the second syringe 170. When the foaming test device 100 is switched to the third pipeline mode, the first valve 130, the second valve 140, and the third valve 150 connect the fluid path between the outside world and the second syringe 170. When the foaming test device 100 is switched to the fourth pipeline mode, the third valve 150 connects the fluid path between the second syringe 170 and the indwelling needle. When the foaming test device 100 is switched to the fifth pipeline mode, the second valve 140 and the third valve 150 connect the fluid path between the first syringe 160 and the indwelling needle. When the foaming test device 100 is switched to the sixth pipeline mode, the second valve 140 and the third valve 150 connect the fluid path between the first syringe 160 and the second syringe 170. It should be noted that in the present application, for example, when the foaming test device 100 is switched to the first pipeline mode, the first valve 130 and the second valve 140 connect the fluid path between the container 110 and the first syringe 160, and the second valve 140 closes the interface connected to the indwelling needle. For example, when the foaming test device 100 is switched to the second pipeline mode, the first valve 130, the second valve 140, and the third valve 150 connect the fluid path between the container 110 and the second syringe 170, and the third valve 150 closes the interface connected to the indwelling needle. For another example, when the foaming test device 100 is switched to the fifth pipeline mode, the second valve 140 and the third valve 150 connect the fluid path between the first syringe 160 and the indwelling needle, and the second valve 140 closes the interface connected to the container 110. That is to say, when one section of the pipeline is connected, the interface of the valve connecting the remaining pipelines is closed.

[0036] The first end 121 of the tubing 120 in the foaming test device 100 of the present application is connected to a container 110 containing physiological saline. Because the entire device is automated, the device automatically extracts physiological saline during the foaming test. Furthermore, the container 110, the first valve 130, the first syringe 160, and the second syringe 170 are sequentially arranged along the first end 121 toward the second end 122 of the tubing 120. The second syringe 170 is configured to inject the obtained foaming liquid (microbubble embolic contrast agent) into the human body. Based on the foaming test device 100's ability to automatically extract physiological saline, after the second syringe 170 extracts blood, the first syringe 160 can push the extracted physiological saline into the human body to clean the tubing and prevent blood from clotting and blocking the tubing. In addition, after the foaming liquid in the second syringe 170 is injected into the human body, the second syringe 170 and the first syringe 160 sequentially inject physiological saline into the human body, which can push the microbubble contrast agent into the human body as much as possible and also clean the pipeline. If the foaming test fails, it will not affect the next foaming test.

[0037] In one embodiment, referring to Figure 1 , the pipeline 120 is arranged along a straight line. In this application, the pipeline 120 is arranged along a straight line, and the first syringe 160 and the second syringe 170 are arranged side by side, which can minimize the device and facilitate use.

[0038] In addition, the foaming test device 100 of the present application includes a first syringe driver 180 and a second syringe driver 190. The first syringe driver 180 includes a first syringe driver body and a first syringe driver output 181 connected to each other. The first syringe driver output 181 is connected to the piston of the first syringe. The first syringe driver body can drive the first syringe driver output 181 to move, thereby driving the piston of the first syringe 160. The second syringe driver 190 includes a second syringe body and a second syringe driver output 191 connected to each other. The second syringe driver output 191 is connected to the piston of the second syringe 170. The second syringe driver body can drive the second syringe driver output 191 to move, thereby driving the piston of the second syringe. Specifically, the first syringe driver 180 and the second syringe driver 190 are both screw modules. Position sensors are correspondingly provided at the first syringe driver output end 181 and the second syringe driver output end 191, and are configured to sense the movement positions of the first syringe driver output end 181 and the second syringe driver output end 191 to prevent over-movement and safety problems.

[0039] In one embodiment, the foaming test device 100 further includes an air filter 200 , which is connected to one of the interfaces of the first valve 130 and is configured to purify the air entering from the outside to ensure that the foaming test is performed more safely.

[0040] 1 , the foaming test apparatus 100 further includes a first ultrasonic bubble sensor 210 . The first ultrasonic bubble sensor 210 is disposed on the pipeline 120 between the container 110 and the first valve 130 , and is configured to monitor whether there are bubbles when the saline solution passes through the pipeline 120 to confirm whether the pipeline 120 is leaking.

[0041] Specifically, when the first syringe 160 and the second syringe 170 extract normal saline, normal saline is extracted under normal circumstances. When an abnormal situation occurs, such as poor sealing of the joint and leakage, some air may be extracted. When air passes through the pipe corresponding to the first ultrasonic bubble sensor 210, the first ultrasonic bubble sensor 210 outputs a high level. When the pipe contains normal saline, it outputs a low level. The control system determines whether the passing object is air bubbles through the high and low level signals. When there are bubbles, the system will alarm and stop the next operation, thereby ensuring that the foaming injection device can extract normal saline.

[0042] Please refer to Figure 1. The foaming test device 100 also includes a second ultrasonic bubble sensor 220. The second ultrasonic bubble sensor 220 is correspondingly arranged at a position between the second syringe 170 and the indwelling needle on the pipeline 120, and is configured to monitor whether there is air or large bubbles passing through during the injection of the foaming liquid or the injection of normal saline to ensure the safety of the injection. Specifically, when the foaming liquid is injected into the human body, the foaming liquid will flow through the position of the pipeline 120 corresponding to the second ultrasonic bubble sensor 220. At this time, if air or large bubbles pass through, the second ultrasonic bubble sensor 220 will sense it and output a low-level signal to the control system. The control system will alarm and take corresponding measures to ensure that the foaming liquid injected into the human vein is safe and reliable. In this application, the first ultrasonic bubble sensor 210 and the second ultrasonic bubble sensor 220 can also be replaced with other types of sensors such as vision and blood oxygen.

[0043] Referring to Figure 2 , the foaming test device 100 also includes a blood oxygen sensor 230 . This sensor is positioned between the second syringe 170 and the indwelling needle on the pipeline 120 . It is configured to monitor whether blood is drawn within a specified timeframe to ensure safe blood drawing. This prevents the second syringe 170 from failing to draw blood, which could lead to negative pressure within the syringe 170 and potentially damage the device or the user. The blood oxygen sensor 230 in this application can also be replaced with other types of sensors, such as infrared sensors or visual sensors.

[0044] Referring to FIG. 2 , the foaming test apparatus 100 further includes a micro-camera 240, which is positioned relative to the second syringe 170 and configured to capture images of the foaming liquid to confirm the blood content and the number and size of microbubbles in the foaming liquid. Specifically, the micro-camera 240 transmits the captured images to a control system. The control system determines whether the second syringe 170 has drawn a sufficient amount of blood based on the color and level of the foaming liquid within the second syringe 170. If no blood is drawn, the liquid within the second syringe 170 is a mixture of saline and air, which is relatively colorless. This means that the micro-camera 240 is configured to provide a secondary confirmation of whether the second syringe 170 has drawn blood. If no blood is drawn or the amount of blood is insufficient, the number of microbubble plugs in the foaming liquid will be very small and easily break, resulting in large bubbles that are difficult to detect. On the other hand, the control system calculates the number and size of the microbubble emboli in the second syringe 170 shown in the image (it should be noted that a large number of large images need to be provided to the control system in the early stage for training. The control system continuously learns and can eventually feedback the number and size of the microbubbles based on the images sent by the micro camera 240). This serves as a reference for the final inspection result. If the number of microbubble emboli is too small, the final inspection result may be inaccurate. If the microbubble emboli are too large, the final inspection result may also be inaccurate.

[0045] Please refer to Figure 4. The foaming test device 100 also includes a thrust sensor, which includes at least a first thrust sensor 250 and a second thrust sensor 260. The first thrust sensor 250 is set corresponding to the output end 181 of the first syringe driver. When the foaming liquid is mixed or the first syringe 160 injects physiological saline into the human body, the first thrust sensor 250 is configured to sense the injection thrust of the output end 181 of the first syringe driver to ensure injection safety; the second thrust sensor 260 is set corresponding to the output end 191 of the second syringe driver. When the foaming liquid is mixed or the second syringe 170 injects physiological saline into the human body, the second thrust sensor 260 is configured to sense the injection thrust of the output end 191 of the second syringe driver to ensure injection safety. Specifically, during an injection, the catheter may collide with the patient's blood vessel wall, causing the needle port to become blocked or the needle to move. This can cause a sharp increase in injection pressure. Continuing the injection in this situation could damage the patient's blood vessel wall or cause a bulge in the elbow vein. Therefore, when the force sensor detects that the injection force exceeds a certain range and continues to rise, the system issues an alarm and stops the injection to avoid harming the patient. The position of the catheter will then need to be manually adjusted.

[0046] 2 and 3 , the foaming test device 100 of the present application further includes a dust cover device 270 , which includes a dust cover and a dust cover drive member. The dust cover drive member is connected to the dust cover and is configured to drive the dust cover to cover the portion where components such as the air filter 200 , the first syringe 160 , the second syringe 170 , the first valve 130 , the second valve 140 , and the third valve 150 are located.

[0047] The foaming test device 100 also has a boss, with a valve motor installed at the lower end of the boss, and a first syringe 160, a second syringe 170, an air filter 200, a first valve 130, a second valve 140, a third valve 150 and part of the pipeline installed at the upper end, which saves space and facilitates the installation and operation of the dust cover, which is conducive to the miniaturization of the foaming test device 100.

[0048] A variety of monitoring devices are provided in the foaming test device 100 of the present application to maximize the safety of the foaming test. Doctors do not need to pay attention to the operation of the equipment all the time and can use it with confidence. At the same time, it also reduces the operating burden of doctors. There is no need to manually extract physiological saline, air and blood. The device operates in a highly automated manner, which is safe and efficient.

[0049] The present application also provides a system for automatically performing a foaming test, as shown in Figures 6 and 7, comprising any of the foaming test devices 100 described above, a mixing device 400, and a third container 101 contained in the mixing device 400. The mixing device 400 is configured to drive the third container 101 to move so that the contrast agent contained in the third container 101 is fully dissolved in the physiological saline to form a uniform left atrial contrast mixture, and to cause the left atrial contrast mixture to foam. Specifically, the mixing device 400 is configured to drive the third container 101 to move after the first syringe 160 or the second syringe 170 injects the physiological saline from the container 110 into the third container 101, so that the contrast agent in the third container 101 can be quickly and fully dissolved in the physiological saline to form a left atrial contrast mixture, and to shake the left atrial contrast mixture so that the left atrial contrast mixture can be evenly mixed and a large number of high-quality and stable microbubbles can be generated.

[0050] Optionally, referring to FIG6 , in one embodiment, the mixing device 400 is integrated on the foaming test device 100 , thereby integrating the foaming test device 100 with the mixing device 400 , so as to facilitate carrying the mixing device 400 and the foaming test device 100 .

[0051] Please refer to Figure 7. In another embodiment, the mixing device 400 is independent of the foaming test device 100, that is, the mixing device 400 is not integrated on the foaming test device 100, thereby making the system more flexible, so that medical personnel do not need to carry the mixing device 400 when performing the right atrial angiography working mode, or can carry the mixing device 400 for use with different foaming test devices 100.

[0052] This embodiment provides a foaming test method for automatically extracting physiological saline. The method uses the foaming test device 100 in Example 1, and the foaming test method includes the following steps:

[0053] Preparation steps: First, the foaming test device 100 switches to the first pipeline mode, and the first syringe 160 draws physiological saline from the container 110. Then, the foaming test device 100 switches to the second pipeline mode, and the second syringe 170 draws physiological saline from the container 110. The foaming test device 100 switches to the fourth pipeline mode, and the second syringe 170 discharges the physiological saline from the indwelling needle. Finally, the foaming test device 100 switches to the fifth pipeline mode, and the first syringe 160 discharges the physiological saline from the indwelling needle. When the first and second syringes 160, 170 discharge the physiological saline from the indwelling needle, both the first and second syringes 160, 170 should be pushed to the bottom to completely expel the air in the first and second syringes 160, 170. During the preparation step, as the first and second syringes 160, 170 draw physiological saline, the first ultrasonic bubble sensor 210 monitors whether there are bubbles in the physiological saline as it passes through. If bubbles are present, an alarm is issued, and the pipeline 120 is checked for leaks.

[0054] Mixed liquid extraction steps: First, the foaming test device 100 is switched to the first pipeline mode, and the first syringe 160 extracts physiological saline from the container 110; Second, the foaming test device 100 is switched to the second pipeline mode, and the second syringe 170 extracts physiological saline from the container 110; Third, the foaming test device 100 is switched to the third pipeline mode, and the second syringe 170 extracts air from the outside; Fourth, the foaming test device 100 is switched to the fourth pipeline mode, and the second syringe 170 extracts blood from the human body through the indwelling needle to obtain a mixed liquid. In this step, the blood oxygen detection sensor 2 30 monitors whether blood passes through within a specified time period; if not, an alarm is triggered. In the fifth step, the foaming test device 100 switches to the fifth pipeline mode, and the first syringe 160 injects saline into the human body. In this step, the second ultrasonic bubble sensor 220 monitors whether there are large bubbles or air as the foaming liquid passes through. If so, the system triggers an alarm, and the equipment is subsequently adjusted to ensure the safety of the foaming liquid injected into the human vein. Simultaneously, the first thrust sensor 250 senses the thrust of the first syringe driver output 181. If the thrust continues to rise within a certain range, an alarm is triggered, and the indwelling needle is subsequently manually adjusted. Furthermore, in the first and second steps, as the first and second syringes 160 and 170 draw saline, the first ultrasonic bubble sensor 210 monitors whether there are bubbles as the saline passes through. If so, an alarm is triggered, and the pipeline 120 is checked for leaks.

[0055] Foaming solution preparation steps: The foaming test apparatus 100 switches to the sixth pipeline mode. The first and second syringes 160 and 170 inject the mixed solution back and forth. The sum of the injection times from the first and second syringes 160 and 170 is an even number (to ensure that the foaming solution is injected into the body through the second syringe 170), and at least 20 times, to obtain the foaming solution. During this step, the micro-camera 240 captures an image of the foaming solution in the second syringe 170 and transmits the image to the control system to confirm whether the blood content in the foaming solution meets the standard and the number and size of microbubble plugs, providing a reference for the accuracy of subsequent foaming test results.

[0056] The first foaming liquid injection step: After obtaining the foaming liquid, the foaming test device 100 switches to the fourth pipeline mode, and the second syringe 170 injects the foaming liquid into the human body. When the foaming liquid is injected into the human body, the second thrust sensor 260 senses the injection thrust of the second syringe 170 (more specifically, senses the thrust of the output end 191 of the second syringe drive). If the injection thrust continues to rise, the system alarms and stops the injection. The position of the indwelling needle is subsequently adjusted before the test is continued. The second ultrasonic sensor monitors whether there are large bubbles when the foaming liquid passes by. If so, the control system alarms, and the device is checked before the test is carried out to ensure that the foaming liquid injected into the human vein is safe and reliable.

[0057] First tube sealing step: After the first foaming liquid injection step, the foaming test device 100 is first switched to the second pipeline mode, and the second syringe 170 draws physiological saline from the container 110; then the foaming test device 100 is switched to the first pipeline mode, and the first syringe 160 draws physiological saline from the container 110; the foaming test device 100 is then switched to the fourth pipeline mode, and the second syringe 170 injects the physiological saline into the human body; finally, the foaming test device 100 is switched to the fifth pipeline mode, and the first syringe 160 injects the physiological saline into the human body, thereby completing the control group foaming test. In this step, when the first syringe 160 and the second syringe 170 extract normal saline, the first ultrasonic bubble sensor 210 monitors whether there are bubbles when the normal saline flows through, and alarms if there are bubbles. Subsequently, the pipeline 120 is checked and repaired for leaks. At the same time, when the first syringe 160 and the second syringe 170 inject normal saline into the human body, the first thrust sensor 250 senses the thrust of the output end 181 of the first syringe drive component, and the second thrust sensor 260 senses the thrust of the output end 191 of the second syringe drive component. If the thrust sensed by one of the thrust sensors exceeds a certain range and continues to rise, the system alarms.

[0058] Second foaming liquid injection step: Repeat the aforementioned mixed liquid extraction step and foaming liquid preparation step. After obtaining the foaming liquid, the patient blows air or performs a Eustachian tube inflation test. When the blowing or Eustachian tube inflation test action meets the standard, the foaming test device 100 switches to the fourth pipeline mode, and the second syringe 170 injects the foaming liquid into the human body.

[0059] Second tube sealing step: Repeat the first tube sealing step to complete the foaming test of the test group.

[0060] Before the first tube sealing step and the second tube sealing step, there is foaming liquid remaining in the pipeline between the second syringe 170 and the indwelling needle that has not been injected into the human body. The tube sealing step can push the foaming liquid remaining in the pipeline into the human body as much as possible, which not only ensures that sufficient foaming liquid is injected as much as possible, but also cleans the pipeline.

[0061] The device of this application eliminates the need for manual extraction of saline, air, and blood, nor does it require manual foaming. Instead, medical personnel simply install the injection consumables on the device. The subsequent test device automatically completes extraction, foaming, injection, and emptying operations, saving labor costs and enabling a single operator to complete the foaming test. Referring to Figure 5 , this device can also be used with an air blowing device 300. The pressure sensor within the air blowing device 300 detects real-time air pressure, replacing the Valsalva maneuver, resulting in simple operation and high accuracy.

[0062] 8-10 , the present application provides another device 100 ′ for automatically performing a foaming test. The device 100 ′ includes a pipeline 120 ′, a second valve 140 ′, a third valve 150 ′, a first syringe 160 ′, and a second syringe 170 ′.

[0063] The tube 120 ′ has a first end 121 ′ and a second end 122 ′ that are oppositely disposed. The first end 121 ′ is configured to be connected to the first container 101 ′, and the second end 122 ′ is configured to be connected to an external indwelling needle.

[0064] Optionally, the first container 101' is configured to contain a contrast mixture solution, wherein the contrast mixture solution is prepared by mixing physiological saline and powdered contrast agent, and the contrast mixture solution is foamed to form a foamed liquid, which is then configured for left atrium contrast detection.

[0065] The powdered contrast agent is contained in the first container 101 ′, and medical personnel can inject physiological saline into the first container 101 ′ through a syringe, so that the contrast agent is dissolved in the physiological saline to form a contrast mixture.

[0066] Optionally, medical personnel may inject the contrast mixture multiple times through a syringe to fully dissolve the contrast agent in the saline solution and obtain a uniformly mixed contrast mixture; or, medical personnel may shake the first container 101′ to fully dissolve the contrast agent in the saline solution and obtain a uniformly mixed contrast mixture.

[0067] The first syringe 160' and the second syringe 170' are configured to perform push and withdraw actions, respectively.

[0068] The second valve 140 ′ is disposed on the pipeline 120 ′ and has at least three interfaces, two of which are configured to communicate with the pipeline 120 ′, and at least one other interface is configured to communicate with the first syringe 160 ′.

[0069] The third valve 150 ′ is disposed on the pipeline 120 ′ and has at least three interfaces, two of which are configured to communicate with the pipeline 120 ′, and at least one other interface is configured to communicate with the second syringe 170 ′.

[0070] Optionally, the second valve 140' and the third valve 150' are sequentially arranged along the direction from the first end 121' to the second end 122'. In other words, the second valve 140' is connected to the pipeline 120' between the first end 121' and the third valve 150', and the third valve 150' is connected to the pipeline 120' between the second valve 140' and the second end 122'.

[0071] Optionally, the device 100 ′ has a left atrial angiography working mode. In the left atrial angiography working mode, the device 100 ′ has multiple switchable pipeline 120 ′ states, so that the device 100 ′ can automatically complete the preparation of the left atrial foaming solution.

[0072] Optionally, referring to Figures 8-10, in a first embodiment, when the device 100' is switched to the first pipeline 120' state, the second valve 140' is configured to connect the liquid path between the first container 101' and the first syringe 160', and the second valve 140' also closes the pipeline 120' between the first syringe 160' and the third valve 150' to control the first syringe 160' to extract the contrast mixture from the first container 101'.

[0073] When the first syringe 160′ completes the extraction of the contrast mixture, the device 100′ will switch to the second pipeline 120′ state. At this time, the second valve 140′ and the third valve 150′ are set to connect the liquid path between the first syringe 160′ and the second syringe 170′, and the second valve 140′ closes the pipeline 120′ between the first syringe 160′ and the first container 101′, and the third valve 150′ closes the pipeline 120′ between the second syringe 170′ and the second end 122′.

[0074] Then, the first syringe 160′ and the second syringe 170′ cooperate with each other to reciprocately push the contrast mixture back and forth between the first syringe 160′ and the second syringe 170′ until bubble liquid is formed, thereby reducing the resistance of the contrast mixture to the reciprocating movement between the first syringe 160′ and the second syringe 170′ under the cooperation of the first syringe 160′ and the second syringe 170′, improving the efficiency of pushing the contrast mixture, and further shortening the time for the contrast mixture to form bubble liquid, so that the contrast mixture can quickly form bubble liquid in the second pipeline 120′ state, completing the automatic preparation of the left atrial contrast bubble liquid, and thereby improving the preparation efficiency and consistency of the bubble liquid.

[0075] Optionally, compared to setting up only one syringe to push and extract the contrast mixture, this embodiment uses the first syringe 160′ and the second syringe 170′ to cooperate with each other to push the contrast mixture back and forth, which can effectively reduce the resistance of the contrast mixture when it moves back and forth between the first syringe 160′ and the second syringe 170′, thereby further improving the efficiency of bubble liquid preparation.

[0076] Optionally, after the preparation of the foaming solution is completed, the foaming solution is injected into the patient's body through the patient's vein through an indwelling needle, and left atrial foaming detection is performed.

[0077] Optionally, in the state of the second pipeline 120 ′, the first syringe 160 ′ and the second syringe 170 ′ cooperate with each other to push and inject at least 20 times, so that the contrast mixture can form a foaming liquid with good consistency.

[0078] Optionally, the foaming liquid can be injected into the patient's body from the patient's vein through the first syringe 160' via the indwelling needle, or can be injected into the patient's body from the patient's vein through the indwelling needle through the second syringe 170'.

[0079] Optionally, the foaming liquid is injected from the second syringe 170 ′ into the patient's body through the patient's vein via the indwelling needle to shorten the distance the foaming liquid travels before entering the patient's body.

[0080] Alternatively, referring to Figures 9-11 , in a second embodiment, before the device 100' switches to the first conduit 120' state, the device 100' first switches to the third conduit 120' state. At this point, the second valve 140' is configured to connect the fluid path between the second container 110' and the first syringe 160'. The second valve 140' also simultaneously closes the conduit 120' between the first syringe 160' and the third valve 150', thereby controlling the first syringe 160' to draw saline from the second container 110'.

[0081] After the first syringe 160' completes the extraction of saline, the device 100' switches to the fourth conduit 120' state. At this point, the second valve 140' is configured to connect the fluid path between the first container 101' and the first syringe 160'. The second valve 140' also closes the conduit 120' between the first syringe 160' and the third valve 150'. This controls the first syringe 160' to push the extracted saline into the first container 101', thereby mixing the contrast agent contained in the first container 101' with the saline to produce a contrast mixture.

[0082] In this embodiment, medical personnel can manually switch the second end 122' from communicating with the second container 110' in the third conduit 120' state to communicating with the first container 101' in the fourth conduit 120' state. Compared to the first embodiment described above, this embodiment eliminates the need for medical personnel to pre-mix the contrast agent with saline, further reducing their workload and effectively improving the precision of saline dispensing under automated operation.

[0083] Alternatively, referring to Figures 12-13, in a third embodiment, the pipeline 120' includes a first sub-pipeline 123' and a second sub-pipeline 124', the first sub-pipeline 123' has a first end 121' and a second end 122' relative to each other, the second sub-pipeline 124' has a third end 125' and a fourth end 126' relative to each other, the fourth end 126' is configured to be connected to the second container 110', and the second container 110' is configured to accommodate physiological saline.

[0084] The device 100' further comprises a first valve 130' having at least three interfaces, two of which are configured to communicate with the first sub-pipeline 123' and are located between the first end 121' and the second valve 140', and at least one other interface is configured to communicate with the third end 125'.

[0085] Optionally, in the left atrial angiography working mode, the device 100 ′ has a plurality of switchable pipeline 120 ′ states.

[0086] Among them, when the device 100′ is switched to the third pipeline 120′ state, the first valve 130′ and the second valve 140′ are respectively set to connect the liquid path between the second container 110′ and the first syringe 160′, and the first valve 130′ simultaneously closes the pipeline 120′ between the first valve 130′ and the first container 101′, and the second valve 140′ simultaneously closes the pipeline 120′ between the first syringe 160′ and the third valve 150′, so as to control the first syringe 160′ to extract physiological saline from the second container 110′.

[0087] After the first syringe 160′ completes the extraction of physiological saline, the device 100′ is switched to the fourth pipeline 120′ state. At this time, the first valve 130′ and the second valve 140′ are respectively set to connect the liquid path between the first container 101′ and the first syringe 160′, and the first valve 130′ simultaneously closes the second sub-pipeline 124′, and the second valve 140′ simultaneously closes the pipeline 120′ between the first syringe 160′ and the third valve 150′, so as to control the first syringe 160′ to push the extracted physiological saline into the first container 101′, so that the contrast agent contained in the first container 101′ is mixed with the physiological saline to obtain a contrast mixture.

[0088] Optionally, the device 100′ is switched to the first pipeline 120′ state again. At this time, the first valve 130′ and the second valve 140′ are respectively set to connect the liquid path between the first container 101′ and the first syringe 160′, and the first valve 130′ simultaneously closes the second sub-pipeline 124′, and the second valve 140′ simultaneously closes the pipeline 120′ between the first syringe 160′ and the third valve 150′, so as to control the first syringe 160′ to extract the contrast mixture from the first container 101′.

[0089] After the first syringe 160′ completes the extraction of the contrast mixture, the device 100′ is switched to the second pipeline 120′ state. At this time, the second valve 140′ and the third valve 150′ are set to connect the liquid path between the first syringe 160′ and the second syringe 170′, and the second valve 140′ closes the pipeline 120′ between the first syringe 160′ and the first valve 130′, and the third valve 150′ closes the pipeline 120′ between the second syringe 170′ and the second end 122′.

[0090] Then, the first syringe 160 ′ and the second syringe 170 ′ cooperate with each other to reciprocally push the contrast mixture back and forth between the first syringe 160 ′ and the second syringe 170 ′ until bubble liquid is formed.

[0091] Optionally, the third valve 150′ is controlled to connect the second syringe 170′ and the pipeline 120′ before the indwelling needle, and the third valve 150′ simultaneously closes the pipeline 120′ between the second valve 140′ and the third valve 150′, and then the foaming liquid in the second syringe 170′ is pushed into the patient's vein through the indwelling needle and injected into the patient's body.

[0092] In this embodiment, a first valve 130', a first sub-pipeline 123', and a second sub-pipeline 124' are provided to connect the first container 101' and the second container 110' to the pipeline 120', respectively. Thus, by controlling the first valve 130', the pipeline 120' between the first syringe 160' and the first container 101' can be connected while the second sub-pipeline 124' is closed. Furthermore, the pipeline 120' between the first syringe 160' and the second container 110' can be connected while the pipeline 120' between the first valve 130' and the first container 101' is closed. This eliminates the need for medical personnel to switch the pipeline 120' between the first container 101' and the second container 110', thereby enabling automated preparation of left atrial blister solution using the device 100'.

[0093] Optionally, referring to Figures 11-12 and 14 , the device 100 ′ further includes a rack 280 ′. The first container 101 ′ and the second container 110 ′ are respectively disposed on the rack 280 ′.

[0094] In one embodiment, the rack 280 ′ shakes under the action of an external force, driving the first container 101 ′ to shake synchronously, so that the contrast agent contained in the first container 101 ′ is fully dissolved in the physiological saline, and a uniform contrast mixture is obtained.

[0095] In another embodiment, the first container 101 ′ is shaken under the action of an external force to fully dissolve the contrast agent in the physiological saline solution and obtain a uniformly mixed contrast mixture.

[0096] Optionally, the hanger 280′ includes a support arm 281′, a first hanging arm 282′, and a second hanging arm 283′. The first hanging arm 282′ is elastically and swingably connected to the support arm 281′. The first container 101′ is mounted on the first hanging arm 282′. Under the action of an external force, the first hanging arm 282′ drives the first container 101′ to swing synchronously relative to the support arm 281′, thereby fully dissolving the contrast agent contained in the first container 101′ into the saline solution, resulting in a uniformly mixed contrast medium. The second container 110′ is mounted on the second hanging arm 283′.

[0097] Alternatively, the first container 101′ drives the first hanging arm 282′ to swing synchronously relative to the support arm 281′ under the action of external force (such as medical staff using their hands to move it), so that the contrast agent contained in the first container 101′ is fully dissolved in the physiological saline and a uniformly mixed contrast mixture is obtained.

[0098] Optionally, the first hanging arm 282′ is an elastic arm so that the first hanging arm 282′ can swing elastically under the action of external force and drive the first container 101′ to swing synchronously; or, an elastic member is provided between the first hanging arm 282′ and the support arm 281′, and the elastic member can be a spring, a spring sheet, or the like that has a structural member that can be elastically deformed under external force.

[0099] Optionally, the first holding arm 282 ′ clamps the first container 101 ′ so that the first container 101 ′ is inverted on the hanging rack 280 ′.

[0100] Optionally, the device 100 ′ may further include a driving mechanism configured to drive the rack 280 ′ or the first container 101 ′ to shake so that the contrast agent is fully dissolved in the physiological saline to form a contrast mixture.

[0101] Specifically, the driving mechanism can drive the first container 101′ to swing relative to the hanger 280′, or drive the hanger 280′ to swing and drive the first container 101′ to swing synchronously, or drive the first hanging arm 282′ to swing relative to the support arm 281′ to drive the first container 101′ to swing synchronously.

[0102] Alternatively, in other embodiments, the contrast mixture may be drawn back and forth from the first container 101 ′ by the first syringe 160 ′ to fully dissolve the contrast agent in the physiological saline solution and obtain a uniformly mixed contrast mixture.

[0103] The above are merely preferred embodiments of the present application and are not intended to limit the present application. Those skilled in the art will readily appreciate that various modifications and variations are possible. Any modifications, equivalent substitutions, or improvements made within the spirit and principles of the present application shall be included within the scope of protection of the present application. Industrial Applicability

[0104] The device provided in the present application for automatically performing the bubble test can switch between different working modes to form different pipeline modes, so as to be applied to the left atrial bubble test or the right atrial bubble test for screening and detecting various diseases.

Claims

1. A device for automatically performing a foaming test, characterized in that: include: a container configured to contain saline; a pipeline having a first end and a second end disposed opposite to each other, wherein the first end is configured to be connected to the container, and the second end is configured to be connected to an external indwelling needle; a first syringe and a second syringe configured to perform a push and / or withdraw action; A first valve, disposed on the pipeline, having at least three interfaces, two of which are configured to communicate with the pipeline, and at least one other interface is configured to communicate with the outside; A second valve, disposed on the pipeline, having at least three interfaces, two of which are configured to communicate with the pipeline, and at least one other interface is configured to communicate with the first syringe; A third valve is disposed on the pipeline, and has at least three interfaces, two of which are configured to communicate with the pipeline, and at least one other interface is configured to communicate with the second syringe; the first valve, the second valve and the third valve are sequentially disposed in a direction from the first end to the second end; The device for automatically performing a foaming test can be switched to different working modes. When switched to the first pipeline mode, the first valve and the second valve are configured to connect the liquid path between the container and the first syringe; when switched to the second pipeline mode, the first valve, the second valve and the third valve are configured to connect the liquid path between the container and the second syringe; when switched to the third pipeline mode, the first valve, the second valve and the third valve are configured to connect the liquid path between the outside and the second syringe; when switched to the fourth pipeline mode, the third valve is configured to connect the liquid path between the second syringe and an externally connected indwelling needle; when switched to the fifth pipeline mode, the second valve and the third valve are configured to connect the liquid path between the first syringe and the externally connected indwelling needle; when switched to the sixth pipeline mode, the second valve and the third valve are configured to connect the liquid path between the first syringe and the second syringe.

2. The device for automatically performing a foaming test according to claim 1, characterized in that: It also includes an air filter, which is connected to the interface of the first valve connected to the outside world and is configured to purify the air entering from the outside world.

3. The device for automatically performing a foaming test according to claim 1, characterized in that: It also includes a first ultrasonic bubble sensor, which is correspondingly arranged at a position between the container and the first valve on the pipeline and is configured to monitor whether there are bubbles when the physiological saline passes through, so as to confirm whether the pipeline is leaking.

4. The device for automatically performing a foaming test according to claim 1, characterized in that: It also includes a second ultrasonic bubble sensor, which is correspondingly arranged at a position between the second syringe and the external indwelling needle on the pipeline, and is configured to monitor whether there is air or large bubbles passing through during the injection of the foaming liquid and the normal saline solution to ensure the safety of the injection; and / or, it also includes a blood oxygen detection sensor, which is correspondingly arranged at a position between the second syringe and the external indwelling needle on the pipeline, and is configured to monitor whether blood passes through within a specified time when blood is drawn to ensure the safety of the blood drawing process.

5. The device for automatically performing a foaming test according to claim 1, characterized in that: The device also includes a micro camera, which is arranged corresponding to the second syringe and configured to take an image of the foaming liquid to confirm the blood content in the foaming liquid and the number and size of the microbubbles.

6. The device for automatically performing a foaming test according to claim 1, characterized in that: It also includes a first thrust sensor and a second thrust sensor. The first thrust sensor is set corresponding to the piston of the first syringe, and is configured to sense the injection thrust of the first syringe when the foaming liquid is mixed or the first syringe injects the liquid into the human body, so as to ensure injection safety; the second thrust sensor is set corresponding to the piston of the second syringe, and is configured to sense the injection thrust of the second syringe when the foaming liquid is mixed or the second syringe injects the liquid into the human body, so as to ensure injection safety.

7. A system for automatically performing a foaming test, characterized in that: A device for automatically performing a foaming test according to any one of claims 1 to 6, further comprising a mixing device, and a third container contained in the mixing device, wherein the mixing device is configured to drive the third container to move so that the contrast agent contained in the third container is fully dissolved in the physiological saline to form a uniform contrast mixture, and to cause the contrast mixture to foam; Wherein, the mixing device is integrated on the foaming test device, or the mixing device is independent of the foaming test device.

8. A method for automatically performing a foaming test, characterized in that: The method is performed using the device for automatically performing a foaming test as described in any one of claims 1 to 6, and the method comprises the following steps: The preparation step includes: switching the device to the first pipeline mode, controlling the first syringe to extract physiological saline from the container; then switching the device to the second pipeline mode, controlling the second syringe to extract physiological saline from the container; then switching the device to the fourth pipeline mode, controlling the second syringe to discharge the physiological saline from the indwelling needle; then switching the device to the fifth pipeline mode, controlling the first syringe to discharge the physiological saline from the indwelling needle; wherein, when the first syringe and the second syringe discharge the physiological saline from the indwelling needle, the first syringe and the second syringe are both pushed to the bottom to exhaust the air in the first syringe and the second syringe; The mixed liquid extraction step includes: switching the device to the first pipeline mode, controlling the first syringe to extract physiological saline from the container; then switching the device to the second pipeline mode, controlling the second syringe to extract physiological saline from the container; then switching the device to the third pipeline mode, controlling the second syringe to extract air from the outside; then switching the device to the fourth pipeline mode, controlling the second syringe to extract blood from the human body through the indwelling needle to obtain a mixed liquid; then switching the device to the fifth pipeline mode, controlling the first syringe to inject the physiological saline into the human body; The foaming liquid preparation step comprises: switching the device to the sixth pipeline mode, controlling the first syringe and the second syringe to push the mixed liquid back and forth, the sum of the number of pushes by the first syringe and the second syringe is an even number, and obtaining the foaming liquid; The first foaming liquid injection step comprises: after obtaining the foaming liquid, switching the device to a fourth pipeline mode, and controlling the second injector to inject the foaming liquid into the human body; The first tube sealing step includes: after the first foaming liquid injection step, switching the device to the second pipeline mode, controlling the second syringe to extract physiological saline from the container; then switching the device to the first pipeline mode, controlling the first syringe to extract physiological saline from the container; then switching the device to the fourth pipeline mode, controlling the second syringe to inject the physiological saline into the human body; then switching the device to the fifth pipeline mode, controlling the first syringe to inject the physiological saline into the human body, thus completing the foaming test of the control group; The second foaming liquid injection step comprises: repeating the mixed liquid extraction step and the foaming liquid preparation step once, and after obtaining the foaming liquid, when the patient's blowing or Eustachian tube inflation inspection action meets the standard, switching the device to the fourth pipeline mode, and controlling the second syringe to inject the foaming liquid into the human body; The second tube sealing step includes: repeating the first tube sealing step, thus completing the foaming test of the test group.

9. A device for automatically performing a foaming test, characterized in that: include: A pipeline having a first end and a second end disposed opposite to each other, wherein the first end is configured to be connected to a first container configured to contain a contrast mixed solution, and the second end is configured to be connected to an externally connected indwelling needle; a first syringe and a second syringe, each configured to perform a push and / or withdraw action; A second valve, disposed on the pipeline, having at least three interfaces, two of which are configured to communicate with the pipeline, and at least one other interface is configured to communicate with the first syringe; a third valve, disposed on the pipeline, having at least three interfaces, two of which are configured to communicate with the pipeline, and at least one other interface is configured to communicate with the second syringe; wherein the second valve and the third valve are sequentially disposed in a direction from the first end to the second end; The device has a left atrial angiography working mode. In the left atrial angiography working mode, the device has a plurality of switchable pipeline states; When switched to the first pipeline state, the second valve is configured to connect the liquid path between the first container and the first syringe to control the first syringe to extract the contrast mixed solution from the first container; When switched to the second pipeline state, the second valve and the third valve are configured to connect the liquid path between the first syringe and the second syringe to control the first syringe and the second syringe to reciprocately push the contrast mixture.

10. The device for automatically performing a foaming test according to claim 9, characterized in that: When switched to the third pipeline state, the second valve is configured to connect the liquid path between the second container and the first syringe to control the first syringe to extract physiological saline from the second container; When switched to the fourth pipeline state, the second valve is configured to connect the liquid path between the first container and the first syringe to control the first syringe to push the extracted saline into the first container, so that the contrast agent contained in the first container is mixed with the saline to obtain the contrast mixture.

11. The device for automatically performing a foaming test according to claim 9, characterized in that: The pipeline includes a first sub-pipeline and a second sub-pipeline, the first sub-pipeline has the first end and the second end opposite to each other, the second sub-pipeline has a third end and a fourth end opposite to each other, the fourth end is configured to be connected to a second container, and the second container is configured to contain physiological saline; The device further comprises a first valve, the first valve having at least three interfaces, two of which are configured to communicate with the first sub-pipeline and are located between the first end and the second valve, and at least one other interface is configured to communicate with the third end; In the left atrial angiography working mode, the device has a plurality of switchable pipeline states; When switched to the third pipeline state, the first valve and the second valve are respectively configured to connect the liquid path between the second container and the first syringe, so as to control the first syringe to extract physiological saline from the second container; When switched to the fourth pipeline state, the first valve and the second valve are respectively configured to connect the liquid path between the first container and the first syringe, so as to control the first syringe to push the extracted physiological saline into the first container, so that the contrast agent contained in the first container is mixed with the physiological saline to obtain the contrast mixed solution; When switched to the first pipeline state, the first valve and the second valve are respectively configured to connect the liquid path between the first container and the first syringe, so as to control the first syringe to extract the contrast mixed solution from the first container; When switched to the second pipeline state, the second valve and the third valve are configured to connect the liquid path between the first syringe and the second syringe to control the first syringe and the second syringe to reciprocately push the contrast mixture.

12. The device for automatically performing a foaming test according to claim 10 or 11, characterized in that: The device further comprises a rack, and the first container and the second container are respectively arranged on the rack; Wherein, the rack and / or the first container are shaken under the action of external force to fully dissolve the contrast agent into the physiological saline solution, and obtain the uniformly mixed contrast mixture; Alternatively, the first syringe reciprocatingly draws and pushes the contrast mixture from the first container to fully dissolve the contrast agent in the physiological saline and obtain the uniformly mixed contrast mixture.

13. The device for automatically performing a foaming test according to claim 12, characterized in that: The rack comprises a support arm and a first hanging arm, the first hanging arm is elastically swingably connected to the support arm, the first container is arranged on the first hanging arm, and the first hanging arm and / or the first container are shaken relative to the support arm under the action of external force so that the contrast agent is fully dissolved in the physiological saline to form the contrast mixed solution; Alternatively, the device further comprises a driving mechanism, and the driving mechanism is configured to drive the rack or the first container to shake so that the contrast agent is fully dissolved in the physiological saline to form the contrast mixture.

14. The device for automatically performing a foaming test according to claim 9, characterized in that: The device further comprises a first valve, which is disposed on the pipeline and has at least three interfaces, two of which are configured to communicate with the pipeline and at least one other interface is configured to communicate with the outside world; The device has a right atrial angiography working mode. In the right atrial angiography working mode, the device has a plurality of switchable pipeline modes, and the first end is configured to be connected to the second container; When switched to the first pipeline mode, the first valve and the second valve are configured to connect the liquid path between the second container and the first syringe to control the first syringe to extract physiological saline from the second container; When switched to the second pipeline mode, the first valve, the second valve and the third valve are configured to connect the liquid path between the second container and the second syringe to control the second syringe to extract physiological saline from the second container; When switched to the third pipeline mode, the first valve, the second valve and the third valve are configured to connect the liquid path between the outside and the second syringe to control the second syringe to extract air from the outside; When switched to the fourth pipeline mode, the third valve is configured to connect the liquid path between the second syringe and the externally connected indwelling needle, so as to control the second syringe to discharge physiological saline from the indwelling needle, or to control the second syringe to extract blood from the human body through the indwelling needle, or to control the second syringe to inject physiological saline or foaming liquid into the human body; When switched to the fifth pipeline mode, the second valve and the third valve are configured to connect the first syringe to the external indwelling needle to discharge the physiological saline from the indwelling needle, or to control the first syringe to inject the physiological saline into the human body; When switched to the sixth pipeline mode, the second valve and the third valve are configured to connect the liquid path between the first syringe and the second syringe to control the first syringe and the second syringe to reciprocate and push the mixed liquid.

15. The device for automatically performing a foaming test according to claim 14, characterized in that: The device also includes a blood oxygen detection sensor, which is correspondingly arranged at a position between the second syringe and the external indwelling needle on the pipeline, and is configured to monitor whether blood passes within a specified time when blood is drawn to ensure that the blood drawing process is carried out safely.

16. The device for automatically performing a foaming test according to claim 14, characterized in that: The device further comprises an air filter, which is connected to an interface of the first valve connected to the outside and is configured to purify air entering from the outside.

17. The device for automatically performing a foaming test according to any one of claims 9 to 11 and 14, characterized in that: The device also includes a first ultrasonic bubble sensor, which is correspondingly arranged at a position between the second container and the first valve on the pipeline, and is configured to monitor whether there are bubbles when the physiological saline passes through, so as to confirm whether the pipeline is leaking; and a second ultrasonic bubble sensor, which is correspondingly arranged at a position between the second syringe and the externally connected indwelling needle on the pipeline, and is configured to monitor whether there are air or large bubbles passing through during the injection of the foaming liquid and the physiological saline, so as to ensure the safety of the injection.

18. The device for automatically performing a foaming test according to any one of claims 9 to 11 and 14, characterized in that: The device also includes a first thrust sensor, which is set corresponding to the piston of the first syringe and is configured to sense the injection thrust of the first syringe when the foaming liquid is mixed or the first syringe injects the liquid into the human body to ensure injection safety; and a second thrust sensor, which is set corresponding to the piston of the second syringe and is configured to sense the injection thrust of the second syringe when the foaming liquid is mixed or the second syringe injects the liquid into the human body to ensure injection safety.

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