Drug delivery system for cannabinoids

Abstract

A method for preparing a cannabinoid containing solution, including the steps of: (a) providing a biomass containing cannabinoids; (b) extracting cannabinoids from the biomass, wherein the extracted cannabinoids are substantially free from a solvent; (c) associating the extracted cannabinoids with a carrier liquid to form a cannabinoid infused carrier liquid; (d) associating the cannabinoid infused carrier liquid with a solid or powder to form a cannabinoid infused carrier powder; and (e) associating the cannabinoid infused carrier powder with water to form liposomes containing cannabinoids in an aqueous solution.

Description

TITLE OF THE INVENTIONDRUG DELIVERY SYSTEM FOR CANNABINOIDSCOPYRIGHT NOTICE

[0000] This application includes material that is subject to copyright protection. The copyright owner has no objection to the facsimile reproduction by anyone of the patent disclosure, as it appears in the United States Patent and Trademark Office files or records, but otherwise reserves all copyright rights whatsoever.CROSS-REFERENCE TO RELATED APPLICATIONS

[0001] Not applicable.STATEMENT REGARDING FEDERALLYSPONSORED RESEARCH OR DEVELOPMENT

[0002] Not applicable.REFERENCE TO A SEQUENCE LISTING

[0003] Not applicable.BACKGROUND OF THE INVENTION1 . Field of the Invention

[0004] The present invention relates in general to cannabinoids, and, more particularly, to novel methods and systems for producing cannabinoids with enhanced bioavailability for maximizing absorption when orally and / or topically administered.2. Background Art

[0005] Cannabinoids, formulations containing cannabinoids, and methods for preparing cannabinoids have been known in the art for years and are the subject of a plurality of patents and publications, including: United States Patent Number 11 ,529,329 entitled "Powdered Composition Comprising a Complex Between a Cannabinoid and a Basic Ion Exchange Resin," United States Patent Number 11 ,207,292 entitled "Cannabidiol Preparations and Its Uses," United States Patent Number 10,080,736 entitled "Microencapsulated Cannabinoid Compositions," United States Patent Number 8,222,292 entitled "Liquid Cannabinoid Formulations," United States Patent Application Publication Number 2021 / 0069103 entitled "Oral Cannabinoid Compositions and Methods for Treating Neuropathic Pain," United States Patent Application Publication Number 2021 / 0059975 entitled "Formulated Cannabis Oil Powder by Nanoemulsification, Methods of Producing and Uses Thereof," United States Patent Application Publication Number 2019 / 0282502 entitled "Encapsulation of Lipophilic Ingredients in Dispersible Spray DriedPowders Suitable for Inhalation," United States Patent Application Publication Number 2018 / 0271826 entitled "Dry Powders of Cannabinoids and Methods for Preparing Dry Powders," International Publication Number WO 2019 / 140321 entitled "Encapsulated Cannabinoid Formulations for Transdermal Delivery," International Publication Number WO 2017 / 183011 entitled "Water Soluble Cannabinoid Inclusion Complexes," and Canadian Patent Number 3,162,353 entitled "Oral Cannabinoid Formulations" - all of which are hereby incorporated herein by reference in their entirety including all references cited therein.

[0006] United States Patent Number 11 ,529,329 appears to disclose a powdered composition, the powdered composition comprising a complex between one or more cannabinoids having at least one phenolic moiety and a basic ion exchange resin. In one embodiment, the '329 patent discloses a cannabinoid chewing gum tablet comprising: (a) a gum base portion comprising water-insoluble gum base ingredients, including natural resins in a range of 8 to 45% by weight of the gum base portion; (b) a bulk portion comprising bulk sweeteners in an amount of 30 to 70% by weight of the cannabinoid chewing gum tablet; and (c) a powdered composition comprising a complex between one or more cannabinoids having at least one phenolic moiety and a basic ion exchange resin, wherein the one or more cannabinoids are present in an amount of at least 1 % by weight of the powdered composition, the one or more cannabinoids being present in the cannabinoid chewing gum tablet in an amount of between 1 and 400 milligrams.

[0007] United States Patent Number 11 ,207,292 appears to disclose cannabidiol (CBD) preparations which are prepared from a botanical origin and are more effective in treating diseases or disorders than preparations of CBD which are synthetic or purified to the extent no other impurities in the form of other cannabinoids are present. Prior CBD compositions have been prepared such that no psychoactive components, e.g., tetrahydrocannabinol (THC), remain in the final CBD preparation. The '292 patent teaches that the absence of such minor impurities reduces the efficacy of CBD treatment.

[0008] United States Patent Number 10,080,736 appears to disclose a cannabinoid-containing composition comprising a plurality of droplets in an emulsion, wherein an individual droplet of said plurality has a size less than or equal to about 500 nanometers and comprises: (i) at least one cannabinoid compound; (ii) at least one terpene compound; and (iii) a compound that counteracts tetrahydrocannabinol (THC) intoxication, wherein the compound is pregnenolone, wherein said composition comprises(1 ) at least one terpene compound present in an amount of at least one microgram, and(2) a natural or naturally-derived surfactant present in an amount such that said composition comprising said plurality of droplets has a shelf half-life of at least 1 week, wherein said individual droplet has a THC content of more than 0% and less than 0.3% by weight, and wherein said at least one cannabinoid compound in said emulsion has a bioavailability of at least twice that of said at least one cannabinoid compound in nondroplet-encapsulated form.

[0009] United States Patent Number 8,222,292 appears to disclose oral cannabinoid formulations, including an aqueous-based oral dronabinol solution, that are stable at room or refrigerated temperatures and may possess improved in vivo absorption profiles with faster onset and lower inter-subject variability. In one embodiment, the '292 patent teaches an oral pharmaceutical solution consisting essentially of: dronabinol, 30- 33% w / w water, about 50% w / w alcohol, 0.01 % w / w butylated hydroxylanisole (BHA) or 0.1 % w / w ethylenediaminetetraacetic acid (EDTA) and 5-21 % w / w co-solvent, having a combined total of 100%, wherein said co-solvent is selected from the group consisting of propylene glycol, polyethylene glycol and combinations thereof, and wherein said oral pharmaceutical solution is stable for at least eighteen months at room or refrigerated temperatures and has in vivo absorption variability of less than 50%.

[0010] United States Patent Application Publication Number 2021 / 0069103 appears to disclose self-emulsifying drug delivery systems that are used in the oral delivery of cannabinoids. The cannabinoids are dissolved in an oily medium (e.g. medium chain triglycerides) together with at least one surfactant to improve dissolution, stability, and bioavailability. Also provided are methods comprising uses of an oral cannabinoid compositions for the treatment of neuropathic pain in a subject.

[0011] United States Patent Application Publication Number 2021 / 0059975 appears to disclose a particular water-dispersible solid formulation of a cannabinoid or a cannabis extract, wherein they are present in the form of a nanoemulsion, and upon dispersion in water said formulation produces nanoparticles (droplets of a submicron size) with an average size of up to about 500 nm. In one embodiment, the '975 reference teaches a water-dispersible powder comprising lipophilic nanospheres having an averaged size between 50 and 900 nm, the nanospheres having an adsorbed layer of at least one solid surfactant and containing a cannabinoid material, wherein the at least one solid surfactant is selected from ammonium glycyrrhizinate, pluronic F-127 and pluronicF68; the powder further comprising at least one solid cryoprotectant selected from sucrose, trehalose and mannitol, and optionally at least one solid carbohydrate selected from maltodextrin and carboxymethyl cellulose (CMC); wherein the nanospheres' structure and size is substantially maintained upon dissolution in a water containing environment.

[0012] United States Patent Application Publication Number 2019 / 0282502 appears to disclose a method of manufacturing a flowable and dispersible powder that includes solubilizing a lipophilic substance in a terpene to form a mixture and treating the mixture to form a nanoemulsion dispersed in an aqueous solution. The aqueous solution includes at least one functional excipient. The nanoemulsion is then spray dried, thereby evaporating first the aqueous portion and then the terpene to form a dry powder formed from solid particles comprising the lipophilic substance.

[0013] United States Patent Application Publication Number 2018 / 0271826 appears to disclose dry powders that comprise a cannabinoid, a polymer binding agent, a dispersing agent, and a bulking agent, and optionally an antioxidant, and are formed by carbon dioxide-assisted nebulization and drying in a flowing dry stream of gas. The dry powders have an aerodynamic particle distribution effective for delivery by respiration into the lungs of a patient. Methods of preparing a dry powder comprise subjecting a solution of a volatile component, a cannabinoid, a polymer binding agent, a dispersing agent, and a bulking agent, and optionally an antioxidant, to carbon dioxide-assisted nebulization, and drying droplets formed by the nebulization in a flowing dry gas stream to form a dry powder. The dry powder has an aerodynamic particle distribution effective for delivery of the dry powder by respiration into a lung of a patient and / or exhibit increased bioavailability and / or storage stability of a cannabinoid. The dry powder can be compressed into a wafer.

[0014] International Publication Number WO 2019 / 140321 appears to disclose preparation of cannabinoid formulations containing: A9-tetrahydrocannabinol (A9-THC), A8-tetrahydrocannabinol (A8-THC), A9-tetrahydrocannabinolic acid (THCa), cannabidiol (CBD), cannabidiolic acid (CBDa), cannabigerol (CBG), cannabichromene (CBC) and cannabinol (CBN), either alone or in combinations henceforth known as cannabis, using an emulsification process to encapsulate cannabinoids. The '321 reference teaches a cannabinoid composition comprising: a cannabinoid preparation ranging from 0.1 % to 20% (w / w); at least one surfactant ranging from 5% to 50% (w / w); at least one co-solventranging from 10% to 70% (w / w); water ranging from 16% to 60% (w / w); and wherein the cannabinoid composition is capable of topical application.

[0015] International Publication Number WO 2017 / 183011 appears to disclose a water-soluble inclusion complex that is formed from a cannabinoid component and a betacyclodextrin. The cannabinoid component may be cannabidiol or tetrahydrocannabinol. The beta-cyclodextrin may comprise 2-hydroxypropyl-beta-cyclodextrin.

[0016] Canadian Patent Number 3,162,353 appears to disclose a cannabinoid containing oral solution. Preferably the cannabinoid is cannabidiol (CBD), cannabidivarin (CBDV) or cannabidiol-C4 (CBD-C4). More preferably the CBD, CBDV or CBD-C4 is present at a concentration of between 25 and 75 mg / ml. More preferably still the CBD, CBDV or CBD-C4 is present at a concentration of 50 mg / ml. In a further embodiment, the oral solution is formulated with one or more edible oils. Preferably the edible oil is sesame oil. It is a preferred embodiment of the invention that the oral formulation comprises a low concentration of ethanol.

[0017] While the above-identified patents and publications do appear to disclose various cannabinoids, formulations containing cannabinoids, and methods for preparing the same, their methods and formulations remain non-desirous and / or problematic inasmuch as, among other things, none of the above-identified references disclose the novel methods and systems for producing cannabinoids with enhanced bioavailability for maximizing absorption when orally and / or topically administered.

[0018] These and other objects of the present invention will become apparent in light of the present specification, claims, and drawings.SUMMARY OF THE INVENTION

[0019] The following presents a simplified summary in order to provide a basic understanding of some aspects of the claimed subject matter. This summary is not an extensive overview, and is not intended to identify key / critical elements or to delineate the scope of the claimed subject matter. Its purpose is to present some concepts in a simplified form as a prelude to the more detailed description that is presented later.

[0020] The present invention is directed to a method for preparing a cannabinoid containing solution / composition, comprising, consisting essentially of, and / or consisting of the steps of: (a) providing a biomass containing cannabinoids; (b) extracting cannabinoids from the biomass, wherein the extracted cannabinoids are substantially free from a solvent; (c) associating the extracted cannabinoids with a carrier liquid to form acannabinoid infused carrier liquid; (d) associating the cannabinoid infused carrier liquid with a free-flowing powder to form a cannabinoid infused carrier powder; and (e) associating the cannabinoid infused carrier powder with water to form liposomes containing cannabinoids in an aqueous solution.

[0021] In a preferred embodiment of the present invention, the step of providing a biomass includes the step of providing at least one of Cannabis indica, Cannabis sativa, Cannabis ruderalis, and combinations thereof.

[0022] In another preferred embodiment of the present invention, the step of extracting includes the step of extracting cannabinoids from the biomass, wherein the extracted cannabinoids are free from solvent.

[0023] In yet another preferred embodiment of the present invention, the step of extracting includes the step of extracting cannabinoids from the biomass, wherein the extracted cannabinoids are free from any solvent used during extraction.

[0024] In one preferred embodiment of the present invention, the step of associating the extracted cannabinoids with a carrier liquid includes the step of dissolving the extracted cannabinoids in the carrier liquid, such as a an edible lipid.

[0025] In a preferred implementation of the present invention, the step of associating the cannabinoid infused carrier liquid with a free-flowing powder includes the step of plating the cannabinoid infused carrier liquid onto a water soluble free-flowing powder to form a cannabinoid infused carrier powder.

[0026] In another preferred implementation of the present invention, the step of associating the cannabinoid infused carrier liquid with a powder includes the step of plating the cannabinoid infused carrier liquid onto a water soluble powder to form a homogeneous cannabinoid infused carrier powder via mechanical mixing selected from the group consisting of a v-blender, a z-blade mixer, an unheated tumbler, a heated tumbler, a vertical mixer, a horizontal mixer, and combinations thereof.

[0027] In yet another preferred implementation of the present invention, the step of associating the cannabinoid infused carrier powder with water includes the step of dissolving the cannabinoid infused carrier powder in water to form liposomes containing cannabinoids in an aqueous solution.

[0028] The present invention is also directed to a method for preparing a cannabinoid containing solution / composition, comprising, consisting essentially of, and / or consisting of the steps of: (a) first providing a biomass containing cannabinoids; (b) secondextracting cannabinoids from the biomass, wherein the extracted cannabinoids are free from any solvent used during extraction; (c) third dissolving the extracted cannabinoids in the carrier liquid consisting of coconut oil; (d) fourth plating the cannabinoid infused carrier liquid onto a water soluble free-flowing powder (e.g., maltodextrin) to form a cannabinoid infused carrier powder via mechanical mixing; and (e) fifth dissolving the cannabinoid infused carrier powder in water to form liposomes containing cannabinoids in an aqueous solution.

[0029] The present invention is further directed to a product, solution, and / or composition prepared by the processes disclosed herein.BRIEF DESCRIPTION OF THE DRAWINGS

[0030] Certain embodiments of the present invention are illustrated by the accompanying figures. It will be understood that the figures are not necessarily to scale and that details not necessary for an understanding of the invention or that render other details difficult to perceive may be omitted.

[0031] It will be further understood that the invention is not necessarily limited to the particular embodiments illustrated herein.

[0032] The invention will now be described with reference to the drawings wherein:

[0033] Figure 1 of the drawings is flow diagram of an extraction process of the present invention; and

[0034] Figures 2-3 of the drawings are product characteristics / properties of materials of the present invention.DETAILED DESCRIPTION OF THE INVENTION

[0035] While this invention is susceptible of embodiment in many different forms and applications, there are shown in the drawings and described herein in detail several specific embodiments with the understanding that the present disclosure is to be considered as an exemplification of the principles of the invention and is not intended to limit the invention to the embodiments illustrated.

[0036] It will be understood that like or analogous elements and / or components, referred to herein, may be identified throughout the drawings by like reference characters. In addition, it will be understood that the drawings are merely schematic representations of one or more embodiments of the invention, and some of the components may have been distorted from their actual scale for purposes of pictorial clarity.

[0037] The present invention is directed to cannabinoids as well as novel methods and systems for producing cannabinoids with enhanced bioavailability for maximizing absorption when orally and / or topically administered.

[0038] The present invention utilizes multi-step methods for preparing a cannabinoid containing solution / composition / material, generally comprising, consisting essentially of and / or consisting of the steps of: (a) providing a biomass containing cannabinoids; (b) extracting cannabinoids from the biomass, wherein the extracted cannabinoids are substantially free from a solvent; (c) associating the extracted cannabinoids with a carrier liquid to form a cannabinoid infused carrier liquid; (d) associating the cannabinoid infused carrier liquid with a solid / powder to form a cannabinoid infused carrier powder; and (e) associating the cannabinoid infused carrier powder with water to form liposomes containing cannabinoids in an aqueous solution. Additional details pertaining to each step are provided herein below.

[0039] In a first step of the present invention, biomass containing cannabinoids are provided for subsequent processing. Non-limiting examples of suitable biomasses comprise Cannabis indica, Cannabis sativa, Cannabis ruderalis, and mixtures thereof. It will be understood that other medicaments and / or adjunct agents (i.e., colorants, flavorants, preservatives, slip agents, viscosity modifiers, rheology modifiers, pH modifiers, minerals, vitamins, etcetera) can be utilized with the cannabinoid containing material.

[0040] In a second step of the present invention, cannabinoids are controllably extracted from the biomass. In this step, the extracted cannabinoids are substantially free (i.e., less than 5 ppm) and / or free from a solvent (e.g., a hydrocarbon containing solvent) used during the extraction.

[0041] As is shown in Figure 1 , and in one embodiment of the present invention, the extraction process 10, utilizes a closed loop extraction system. The system includes one or more material columns 12, color remediation column 14, collection vessel 16, filter dryer 18, heat exchanger 20, recovery pump 22 and solvent tank / vessel 24. The solvent (e.g., an aliphatic hydrocarbon, butane, propane or butane / propane mixture) resides in the solvent tank. The fluid moves from solvent tank 24 to material column(s) 12, to color remediation column 14, and then to collection vessel / honeypot 16 for the injection, and back to the solvent tank via the filter dryer and heat exchanger for the recovery to complete the closed-loop system.

[0042] Preferably, upon starting this process step, a vacuum is created in the entire system, via vacuum pump 26, to get rid of any moisture that might exist. All the components other than solvent tank 24, which is in isolation from the vacuum or negative pressure, are provided with vacuum; this also helps create positive pressure for the injection step of the system. Also, vacuum is important to eliminate any moisture from the system that might contaminate the extraction process.

[0043] Once the system of operational, cold solvent is injected from the solvent tank to the material column, where it absorbs the essential oils out of the biomass / plant matter. As the solvent enters the material column, it is sprayed through a spray ball. The material loaded into the material column is soaked with the solvent. Next, the mixture of the solvent and oil flows through the inline remediation column and into the collection vessel. It is preferred that the recovery does not start until the user can visualize the flow into collection vessel with the help of sight glasses. The solvent / oil mixture is then heated in the collection vessel / honey pot or dewax column so that the solvent can evaporate and leave the vessel. This is attained by heating the jacket of the collection vessel, as well as the filter dryer. Once this is achieved, the solvent starts evaporating and leaves the vessel. The solvent then passes through the filter dryer to get rid of any residual moisture and / or impurities. Next, the working solvent passes through the recovery pump to a heat exchanger. At the heat exchanger, the solvent is cooled to subzero temperature with the help of a chiller. The cold solvent is then injected back to the solvent tank to complete the closed loop cycle. At the heat exchanger, the solvent is cooled down and travels back to the solvent tank. Next, the extracted product gathered from the collection vessel / honey pot is placed in a vacuum oven. The vacuum oven is set to 80 degrees Fahrenheit with a minimum vacuum of -29mm Hg is achieved. The extracted product is left in the oven for up to 24 hours and then tested for any solvents. If any exist, the extracted product is placed back in the oven and a vacuum is pulled again until no solvent is detected via gas chromatography (GC) or other analytical instrumentation.

[0044] In a third step of the present invention, the extracted cannabinoids are associated with and / or dissolved into a carrier liquid to form a cannabinoid infused carrier liquid. Non-limiting examples of carrier liquids include edible lipids, medium chain triglycerides, vegetable oil, coconut oil, corn oil, soybean oil, beef tallow, lard, palm oil, sunflower oil, avocado oil, hemp seed oil, and / or olive oil.

[0045] In a fourth step of the present invention, the cannabinoid infused carrier liquid is associated with a solid or powder, preferably free-flowing, to form a cannabinoid infused carrier solid / powder. Non-limiting examples of solids / powders include those comprising the structure:- wherein Ri-R7are the same or different and selected from the group consisting of H; OH; and an alkyl, cycloalkyl, polycycloalkyl, heterocycloalkyl, aryl, alkaryl, aralkyl, alkoxy, alkanoyl, aroyl, alkenyl, and / or alkynyl group containing approximately 1 to approximately 25 carbon atom(s), wherein the carbon atom(s) may be a linking group to, or part of, a halogen, a N, O, and / or S containing moiety, and / or one or more functional groups comprising alcohols, esters, ammonium salts, phosphonium salts, and combinations thereof.

[0046] In a preferred embodiment of the present invention, the solid or powder comprises the structure:and congeners and derivatives thereof.

[0047] In one embodiment of the present invention, the step of associating the cannabinoid infused carrier liquid with a solid or powder includes the step of plating the cannabinoid infused carrier liquid onto a water soluble free-flowing powder consisting of maltodextrin to form a homogeneous cannabinoid infused carrier powder via mechanical mixing selected from the group consisting of a v-blender, a z-blade mixer, an unheated tumbler, a heated tumbler, a vertical mixer, a horizontal mixer, and combinations thereof.

[0048] In a fifth step of the present invention, the cannabinoid infused carrier powder is associated with and / or dissolved into an ingestible polar solvent (e.g., water) to form liposomes containing cannabinoids in a solution.

[0049] Product characteristics / properties of materials prepared using the systems and methods of the present are provided in Figures 2 and 3.

[0050] The foregoing description merely explains and illustrates the invention and the invention is not limited thereto except insofar as the appended claims are so limited, as those skilled in the art who have the disclosure before them will be able to make modifications without departing from the scope of the invention.

[0051] While certain embodiments have been illustrated and described, it should be understood that changes and modifications can be made therein in accordance with ordinary skill in the art without departing from the technology in its broader aspects as defined in the following claims.

[0052] The embodiments, illustratively described herein may suitably be practiced in the absence of any element or elements, limitation or limitations, not specifically disclosed herein. Thus, for example, the terms "comprising," "including," "containing," etcetera shall be read expansively and without limitation. Additionally, the terms and expressions employed herein have been used as terms of description and not of limitation, and there is no intention in the use of such terms and expressions of excluding any equivalents of the features shown and described or portions thereof, but it is recognized that various modifications are possible within the scope of the claimed technology. Additionally, the phrase "consisting essentially of" will be understood to include those elements specifically recited and those additional elements that do not materially affect the basic and novel characteristics of the claimed technology. The phrase "consisting of" excludes any element not specified.

[0053] The present disclosure is not to be limited in terms of the particular embodiments described in this application. Many modifications and variations can bemade without departing from its spirit and scope, as will be apparent to those skilled in the art. Functionally equivalent methods and compositions within the scope of the disclosure, in addition to those enumerated herein, will be apparent to those skilled in the art from the foregoing descriptions. Such modifications and variations are intended to fall within the scope of the appended claims. The present disclosure is to be limited only by the terms of the appended claims, along with the full scope of equivalents to which such claims are entitled. It is to be understood that this disclosure is not limited to particular methods, reagents, compounds compositions or biological systems, which can of course vary. It is also to be understood that the terminology used herein is for the purpose of describing particular embodiments only, and is not intended to be limiting.

[0054] In addition, where features or aspects of the disclosure are described in terms of Markush groups, those skilled in the art will recognize that the disclosure is also thereby described in terms of any individual member or subgroup of members of the Markush group.

[0055] As will be understood by one skilled in the art, for any and all purposes, particularly in terms of providing a written description, all ranges disclosed herein also encompass any and all possible subranges and combinations of subranges thereof. Any listed range can be easily recognized as sufficiently describing and enabling the same range being broken down into at least equal halves, thirds, quarters, fifths, tenths, etcetera. As a non-limiting example, each range discussed herein can be readily broken down into a lower third, middle third and upper third, etcetera. As will also be understood by one skilled in the art all language such as "up to," "at least," "greater than," "less than," and the like, include the number recited and refer to ranges which can be subsequently broken down into subranges as discussed above. Finally, as will be understood by one skilled in the art, a range includes each individual member.

[0056] All publications, patent applications, issued patents, and other documents referred to in this specification are herein incorporated by reference as if each individual publication, patent application, issued patent, or other document was specifically and individually indicated to be incorporated by reference in its entirety. Definitions that are contained in text incorporated by reference are excluded to the extent that they contradict definitions in this disclosure.

[0057] Other embodiments are set forth in the following claims.

Claims

WHAT IS CLAIMED IS:1 . A method for preparing a cannabinoid containing solution, comprising the steps of:- providing a biomass containing cannabinoids;- extracting cannabinoids from the biomass, wherein the extracted cannabinoids are substantially free from a solvent;- associating the extracted cannabinoids with a carrier liquid to form a cannabinoid infused carrier liquid;- associating the cannabinoid infused carrier liquid with a powder to form a cannabinoid infused carrier powder; and- associating the cannabinoid infused carrier powder with water to form liposomes containing cannabinoids in an aqueous solution.

2. The method according to claim 1 , wherein the step of providing a biomass includes the step of providing at least one of Cannabis indica, Cannabis sativa, Cannabis ruderalis, and mixtures thereof.

3. The method according to claim 1 , wherein the step of extracting includes the step of extracting cannabinoids from the biomass, wherein the extracted cannabinoids are free from a hydrocarbon containing solvent.

4. The method according to claim 1 , wherein the step of extracting includes the step of extracting cannabinoids from the biomass, wherein the extracted cannabinoids are free from any solvent used during extraction.

5. The method according to claim 1 , wherein the step of associating the extracted cannabinoids with a carrier liquid includes the step of dissolving the extracted cannabinoids in the carrier liquid selected from the group consisting of an edible lipid, a medium chain triglyceride, vegetable oil, coconut oil, corn oil, soybean oil, beef tallow, lard, palm oil, sunflower oil, avocado oil, hemp seed oil, olive oil, and mixtures thereof.

6. The method according to claim 1 , wherein the step of associating the cannabinoid infused carrier liquid with a powder includes the step of plating the cannabinoid infusedcarrier liquid onto a water soluble free-flowing powder consisting of maltodextrin to form a cannabinoid infused carrier powder.

7. The method according to claim 1 , wherein the step of associating the cannabinoid infused carrier liquid with a free-flowing powder includes the step of plating the cannabinoid infused carrier liquid onto a water soluble powder to form a homogeneous cannabinoid infused carrier powder via mechanical mixing selected from the group consisting of a v-blender, a z-blade mixer, an unheated tumbler, a heated tumbler, a vertical mixer, a horizontal mixer, and combinations thereof.

8. The method according to claim 1 , wherein the step of associating the cannabinoid infused carrier powder with water includes the step of dissolving the cannabinoid infused carrier powder in water to form liposomes containing cannabinoids in an aqueous solution.

9. A method for preparing a cannabinoid containing solution, consisting of the steps of:- first providing a biomass containing cannabinoids;- second extracting cannabinoids from the biomass, wherein the extracted cannabinoids are free from any solvent used during extraction;- third dissolving the extracted cannabinoids in the carrier liquid consisting of coconut oil;- fourth plating the cannabinoid infused carrier liquid onto a water soluble free- flowing powder consisting of maltodextrin to form a cannabinoid infused carrier powder via mechanical mixing; and- fifth dissolving the cannabinoid infused carrier powder in water to form liposomes containing cannabinoids in an aqueous solution.

10. A product prepared by the process of claim 1 .11 . A product prepared by the process of claim 2.

12. A product prepared by the process of claim 3.

13. A product prepared by the process of claim 4.

14. A product prepared by the process of claim 5.

15. A product prepared by the process of claim 6.

16. A product prepared by the process of claim 7.

17. A product prepared by the process of claim 8.

18. A product prepared by the process of claim 9.

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